-- dump date   	20140619_041401
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
326427000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
326427000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427000003	Walker A motif; other site
326427000004	ATP binding site [chemical binding]; other site
326427000005	Walker B motif; other site
326427000006	arginine finger; other site
326427000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
326427000008	DnaA box-binding interface [nucleotide binding]; other site
326427000009	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
326427000010	C-terminal peptidase (prc); Region: prc; TIGR00225
326427000011	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
326427000012	protein binding site [polypeptide binding]; other site
326427000013	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
326427000014	Domain interface; other site
326427000015	Peptide binding site; other site
326427000016	Active site tetrad [active]
326427000017	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
326427000018	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326427000019	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427000020	homodimer interface [polypeptide binding]; other site
326427000021	catalytic residue [active]
326427000022	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
326427000023	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
326427000024	active site
326427000025	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
326427000026	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
326427000027	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
326427000028	Walker A/P-loop; other site
326427000029	ATP binding site [chemical binding]; other site
326427000030	Q-loop/lid; other site
326427000031	ABC transporter signature motif; other site
326427000032	Walker B; other site
326427000033	D-loop; other site
326427000034	H-loop/switch region; other site
326427000035	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
326427000036	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326427000037	active site
326427000038	HIGH motif; other site
326427000039	nucleotide binding site [chemical binding]; other site
326427000040	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
326427000041	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
326427000042	active site
326427000043	KMSKS motif; other site
326427000044	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
326427000045	tRNA binding surface [nucleotide binding]; other site
326427000046	anticodon binding site; other site
326427000047	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
326427000048	PGAP1-like protein; Region: PGAP1; pfam07819
326427000049	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326427000050	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427000051	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427000052	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427000053	GAF domain; Region: GAF; pfam01590
326427000054	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427000055	GAF domain; Region: GAF_3; pfam13492
326427000056	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427000057	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427000058	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427000059	GAF domain; Region: GAF; pfam01590
326427000060	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427000061	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427000062	GAF domain; Region: GAF_2; pfam13185
326427000063	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427000064	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427000065	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427000066	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427000067	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427000068	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427000069	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427000070	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427000071	GAF domain; Region: GAF; pfam01590
326427000072	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427000073	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427000074	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
326427000075	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427000076	putative active site [active]
326427000077	heme pocket [chemical binding]; other site
326427000078	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427000079	dimer interface [polypeptide binding]; other site
326427000080	phosphorylation site [posttranslational modification]
326427000081	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427000082	ATP binding site [chemical binding]; other site
326427000083	Mg2+ binding site [ion binding]; other site
326427000084	G-X-G motif; other site
326427000085	Response regulator receiver domain; Region: Response_reg; pfam00072
326427000086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427000087	active site
326427000088	phosphorylation site [posttranslational modification]
326427000089	intermolecular recognition site; other site
326427000090	dimerization interface [polypeptide binding]; other site
326427000091	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
326427000092	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326427000093	metal binding site [ion binding]; metal-binding site
326427000094	active site
326427000095	I-site; other site
326427000096	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
326427000097	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
326427000098	putative trimer interface [polypeptide binding]; other site
326427000099	putative CoA binding site [chemical binding]; other site
326427000100	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
326427000101	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
326427000102	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
326427000103	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
326427000104	short chain dehydrogenase; Provisional; Region: PRK07454
326427000105	classical (c) SDRs; Region: SDR_c; cd05233
326427000106	NAD(P) binding site [chemical binding]; other site
326427000107	active site
326427000108	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
326427000109	homodecamer interface [polypeptide binding]; other site
326427000110	GTP cyclohydrolase I; Provisional; Region: PLN03044
326427000111	active site
326427000112	putative catalytic site residues [active]
326427000113	zinc binding site [ion binding]; other site
326427000114	GTP-CH-I/GFRP interaction surface; other site
326427000115	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
326427000116	active site
326427000117	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
326427000118	active site
326427000119	DNA polymerase III subunit beta; Validated; Region: PRK05643
326427000120	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
326427000121	putative DNA binding surface [nucleotide binding]; other site
326427000122	dimer interface [polypeptide binding]; other site
326427000123	beta-clamp/clamp loader binding surface; other site
326427000124	beta-clamp/translesion DNA polymerase binding surface; other site
326427000125	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427000126	active site
326427000127	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326427000128	phosphorylation site [posttranslational modification]
326427000129	intermolecular recognition site; other site
326427000130	dimerization interface [polypeptide binding]; other site
326427000131	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326427000132	DNA binding residues [nucleotide binding]
326427000133	dimerization interface [polypeptide binding]; other site
326427000134	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
326427000135	Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481
326427000136	active site
326427000137	catalytic triad [active]
326427000138	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
326427000139	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
326427000140	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
326427000141	Potassium binding sites [ion binding]; other site
326427000142	Cesium cation binding sites [ion binding]; other site
326427000143	acetylornithine deacetylase; Validated; Region: PRK06915
326427000144	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
326427000145	metal binding site [ion binding]; metal-binding site
326427000146	dimer interface [polypeptide binding]; other site
326427000147	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
326427000148	active site
326427000149	dimer interface [polypeptide binding]; other site
326427000150	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
326427000151	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
326427000152	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
326427000153	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
326427000154	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
326427000155	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
326427000156	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427000157	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427000158	GAF domain; Region: GAF; cl17456
326427000159	PAS domain; Region: PAS; smart00091
326427000160	Isochorismatase family; Region: Isochorismatase; pfam00857
326427000161	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
326427000162	catalytic triad [active]
326427000163	conserved cis-peptide bond; other site
326427000164	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
326427000165	PhoU domain; Region: PhoU; pfam01895
326427000166	PhoU domain; Region: PhoU; pfam01895
326427000167	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
326427000168	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
326427000169	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
326427000170	substrate binding pocket [chemical binding]; other site
326427000171	dimer interface [polypeptide binding]; other site
326427000172	inhibitor binding site; inhibition site
326427000173	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
326427000174	B12 binding site [chemical binding]; other site
326427000175	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
326427000176	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
326427000177	Cytokine receptor motif; other site
326427000178	PAS domain; Region: PAS_9; pfam13426
326427000179	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427000180	putative active site [active]
326427000181	heme pocket [chemical binding]; other site
326427000182	PAS domain; Region: PAS_9; pfam13426
326427000183	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427000184	putative active site [active]
326427000185	heme pocket [chemical binding]; other site
326427000186	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
326427000187	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326427000188	metal binding site [ion binding]; metal-binding site
326427000189	active site
326427000190	I-site; other site
326427000191	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
326427000192	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
326427000193	Protein of unknown function DUF58; Region: DUF58; pfam01882
326427000194	von Willebrand factor type A domain; Region: VWA_2; pfam13519
326427000195	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596
326427000196	active site
326427000197	Zn binding site [ion binding]; other site
326427000198	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
326427000199	putative trimer interface [polypeptide binding]; other site
326427000200	putative active site [active]
326427000201	putative substrate binding site [chemical binding]; other site
326427000202	putative CoA binding site [chemical binding]; other site
326427000203	isocitrate lyase; Provisional; Region: PRK15063
326427000204	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
326427000205	tetramer interface [polypeptide binding]; other site
326427000206	active site
326427000207	Mg2+/Mn2+ binding site [ion binding]; other site
326427000208	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
326427000209	homodimer interface [polypeptide binding]; other site
326427000210	chemical substrate binding site [chemical binding]; other site
326427000211	oligomer interface [polypeptide binding]; other site
326427000212	metal binding site [ion binding]; metal-binding site
326427000213	threonine dehydratase; Provisional; Region: PRK08198
326427000214	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
326427000215	tetramer interface [polypeptide binding]; other site
326427000216	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427000217	catalytic residue [active]
326427000218	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
326427000219	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
326427000220	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
326427000221	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
326427000222	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
326427000223	Protein of unknown function (DUF1641); Region: DUF1641; pfam07849
326427000224	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
326427000225	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
326427000226	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
326427000227	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
326427000228	active site residue [active]
326427000229	Transcriptional regulator [Transcription]; Region: LysR; COG0583
326427000230	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
326427000231	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
326427000232	dimerization interface [polypeptide binding]; other site
326427000233	Putative zinc-finger; Region: zf-HC2; pfam13490
326427000234	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
326427000235	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326427000236	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326427000237	DNA binding residues [nucleotide binding]
326427000238	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
326427000239	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
326427000240	Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973
326427000241	catalytic residues [active]
326427000242	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427000243	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
326427000244	putative substrate translocation pore; other site
326427000245	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
326427000246	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
326427000247	TadE-like protein; Region: TadE; pfam07811
326427000248	TadE-like protein; Region: TadE; pfam07811
326427000249	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
326427000250	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
326427000251	metal ion-dependent adhesion site (MIDAS); other site
326427000252	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
326427000253	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
326427000254	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
326427000255	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
326427000256	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
326427000257	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
326427000258	homodimer interface [polypeptide binding]; other site
326427000259	NADP binding site [chemical binding]; other site
326427000260	substrate binding site [chemical binding]; other site
326427000261	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
326427000262	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
326427000263	ATP-grasp domain; Region: ATP-grasp_4; cl17255
326427000264	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
326427000265	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427000266	Coenzyme A binding pocket [chemical binding]; other site
326427000267	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
326427000268	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
326427000269	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
326427000270	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
326427000271	nucleophile elbow; other site
326427000272	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427000273	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326427000274	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326427000275	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326427000276	active site
326427000277	ATP binding site [chemical binding]; other site
326427000278	substrate binding site [chemical binding]; other site
326427000279	activation loop (A-loop); other site
326427000280	FOG: WD40 repeat [General function prediction only]; Region: COG2319
326427000281	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326427000282	structural tetrad; other site
326427000283	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
326427000284	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
326427000285	Cysteine-rich domain; Region: CCG; pfam02754
326427000286	Cysteine-rich domain; Region: CCG; pfam02754
326427000287	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
326427000288	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
326427000289	hydroxyglutarate oxidase; Provisional; Region: PRK11728
326427000290	glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377
326427000291	glycerol kinase; Provisional; Region: glpK; PRK00047
326427000292	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
326427000293	N- and C-terminal domain interface [polypeptide binding]; other site
326427000294	active site
326427000295	MgATP binding site [chemical binding]; other site
326427000296	catalytic site [active]
326427000297	metal binding site [ion binding]; metal-binding site
326427000298	putative homotetramer interface [polypeptide binding]; other site
326427000299	glycerol binding site [chemical binding]; other site
326427000300	homodimer interface [polypeptide binding]; other site
326427000301	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
326427000302	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
326427000303	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
326427000304	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
326427000305	amphipathic channel; other site
326427000306	Asn-Pro-Ala signature motifs; other site
326427000307	DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388
326427000308	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427000309	Walker A motif; other site
326427000310	ATP binding site [chemical binding]; other site
326427000311	Walker B motif; other site
326427000312	arginine finger; other site
326427000313	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
326427000314	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326427000315	acyl-coenzyme A oxidase; Region: PLN02526
326427000316	active site
326427000317	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
326427000318	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
326427000319	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
326427000320	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
326427000321	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
326427000322	Putative glucoamylase; Region: Glycoamylase; pfam10091
326427000323	Transcriptional regulators [Transcription]; Region: PurR; COG1609
326427000324	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
326427000325	DNA binding site [nucleotide binding]
326427000326	domain linker motif; other site
326427000327	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
326427000328	dimerization interface [polypeptide binding]; other site
326427000329	ligand binding site [chemical binding]; other site
326427000330	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
326427000331	Putative glucoamylase; Region: Glycoamylase; pfam10091
326427000332	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
326427000333	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427000334	dimer interface [polypeptide binding]; other site
326427000335	conserved gate region; other site
326427000336	putative PBP binding loops; other site
326427000337	ABC-ATPase subunit interface; other site
326427000338	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
326427000339	NHL repeat; Region: NHL; pfam01436
326427000340	Tetratricopeptide repeat; Region: TPR_16; pfam13432
326427000341	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427000342	TPR motif; other site
326427000343	binding surface
326427000344	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
326427000345	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
326427000346	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427000347	dimer interface [polypeptide binding]; other site
326427000348	conserved gate region; other site
326427000349	putative PBP binding loops; other site
326427000350	ABC-ATPase subunit interface; other site
326427000351	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427000352	dimer interface [polypeptide binding]; other site
326427000353	conserved gate region; other site
326427000354	putative PBP binding loops; other site
326427000355	ABC-ATPase subunit interface; other site
326427000356	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
326427000357	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
326427000358	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
326427000359	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
326427000360	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
326427000361	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
326427000362	Putative carbohydrate binding domain; Region: CBM_X; pfam06204
326427000363	Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_4; cd11751
326427000364	Protein of unknown function (DUF507); Region: DUF507; cl01112
326427000365	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427000366	Coenzyme A binding pocket [chemical binding]; other site
326427000367	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
326427000368	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
326427000369	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
326427000370	motif 1; other site
326427000371	active site
326427000372	motif 2; other site
326427000373	motif 3; other site
326427000374	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
326427000375	acyl-coenzyme A oxidase; Region: PLN02526
326427000376	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326427000377	active site
326427000378	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
326427000379	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
326427000380	active site
326427000381	PAS fold; Region: PAS_4; pfam08448
326427000382	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427000383	putative active site [active]
326427000384	heme pocket [chemical binding]; other site
326427000385	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427000386	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326427000387	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427000388	dimer interface [polypeptide binding]; other site
326427000389	phosphorylation site [posttranslational modification]
326427000390	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427000391	ATP binding site [chemical binding]; other site
326427000392	Mg2+ binding site [ion binding]; other site
326427000393	G-X-G motif; other site
326427000394	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
326427000395	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326427000396	metal binding site [ion binding]; metal-binding site
326427000397	active site
326427000398	I-site; other site
326427000399	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
326427000400	intracellular protease, PfpI family; Region: PfpI; TIGR01382
326427000401	proposed catalytic triad [active]
326427000402	conserved cys residue [active]
326427000403	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326427000404	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427000405	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
326427000406	transmembrane helices; other site
326427000407	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
326427000408	TrkA-C domain; Region: TrkA_C; pfam02080
326427000409	TrkA-C domain; Region: TrkA_C; pfam02080
326427000410	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
326427000411	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
326427000412	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
326427000413	active site
326427000414	substrate binding site [chemical binding]; other site
326427000415	Mg2+ binding site [ion binding]; other site
326427000416	Lamin Tail Domain; Region: LTD; pfam00932
326427000417	Nuclease A inhibitor-like protein; Region: NuiA; pfam07924
326427000418	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
326427000419	ATP-grasp domain; Region: ATP-grasp_4; cl17255
326427000420	Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; pfam14403
326427000421	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
326427000422	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
326427000423	intersubunit interface [polypeptide binding]; other site
326427000424	Protein of unknown function, DUF547; Region: DUF547; pfam04784
326427000425	Uncharacterized conserved protein [Function unknown]; Region: COG1543
326427000426	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
326427000427	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
326427000428	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326427000429	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326427000430	active site
326427000431	ATP binding site [chemical binding]; other site
326427000432	substrate binding site [chemical binding]; other site
326427000433	activation loop (A-loop); other site
326427000434	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
326427000435	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326427000436	phosphopeptide binding site; other site
326427000437	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326427000438	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326427000439	DNA binding site [nucleotide binding]
326427000440	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
326427000441	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
326427000442	hinge; other site
326427000443	active site
326427000444	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
326427000445	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
326427000446	NAD binding site [chemical binding]; other site
326427000447	homodimer interface [polypeptide binding]; other site
326427000448	active site
326427000449	substrate binding site [chemical binding]; other site
326427000450	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326427000451	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326427000452	active site
326427000453	ATP binding site [chemical binding]; other site
326427000454	substrate binding site [chemical binding]; other site
326427000455	activation loop (A-loop); other site
326427000456	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
326427000457	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
326427000458	Zn binding sites [ion binding]; other site
326427000459	MoxR-like ATPases [General function prediction only]; Region: COG0714
326427000460	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427000461	Walker A motif; other site
326427000462	ATP binding site [chemical binding]; other site
326427000463	Walker B motif; other site
326427000464	arginine finger; other site
326427000465	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
326427000466	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
326427000467	FtsX-like permease family; Region: FtsX; pfam02687
326427000468	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
326427000469	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
326427000470	FtsX-like permease family; Region: FtsX; pfam02687
326427000471	Acyl CoA binding protein; Region: ACBP; pfam00887
326427000472	acyl-CoA binding pocket [chemical binding]; other site
326427000473	CoA binding site [chemical binding]; other site
326427000474	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
326427000475	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
326427000476	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
326427000477	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326427000478	Ion channel; Region: Ion_trans_2; pfam07885
326427000479	oligoendopeptidase F; Region: pepF; TIGR00181
326427000480	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
326427000481	active site
326427000482	Zn binding site [ion binding]; other site
326427000483	HAS barrel domain; Region: HAS-barrel; pfam09378
326427000484	Domain of unknown function DUF87; Region: DUF87; pfam01935
326427000485	AAA-like domain; Region: AAA_10; pfam12846
326427000486	Response regulator receiver domain; Region: Response_reg; pfam00072
326427000487	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427000488	active site
326427000489	phosphorylation site [posttranslational modification]
326427000490	intermolecular recognition site; other site
326427000491	dimerization interface [polypeptide binding]; other site
326427000492	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
326427000493	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326427000494	active site
326427000495	motif I; other site
326427000496	motif II; other site
326427000497	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326427000498	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
326427000499	active site
326427000500	catalytic site [active]
326427000501	Helix-turn-helix domain; Region: HTH_17; pfam12728
326427000502	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
326427000503	active site
326427000504	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427000505	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
326427000506	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
326427000507	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
326427000508	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427000509	NAD(P) binding site [chemical binding]; other site
326427000510	active site
326427000511	O-Antigen ligase; Region: Wzy_C; cl04850
326427000512	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
326427000513	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
326427000514	Bacterial sugar transferase; Region: Bac_transf; pfam02397
326427000515	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
326427000516	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
326427000517	active site
326427000518	dimer interface [polypeptide binding]; other site
326427000519	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
326427000520	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
326427000521	active site
326427000522	FMN binding site [chemical binding]; other site
326427000523	substrate binding site [chemical binding]; other site
326427000524	3Fe-4S cluster binding site [ion binding]; other site
326427000525	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
326427000526	domain interface; other site
326427000527	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
326427000528	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
326427000529	HSP70 interaction site [polypeptide binding]; other site
326427000530	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
326427000531	substrate binding site [polypeptide binding]; other site
326427000532	dimer interface [polypeptide binding]; other site
326427000533	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
326427000534	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
326427000535	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
326427000536	Response regulator receiver domain; Region: Response_reg; pfam00072
326427000537	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427000538	active site
326427000539	phosphorylation site [posttranslational modification]
326427000540	intermolecular recognition site; other site
326427000541	dimerization interface [polypeptide binding]; other site
326427000542	Protein of unknown function (DUF422); Region: DUF422; pfam04240
326427000543	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551
326427000544	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
326427000545	putative acyl-acceptor binding pocket; other site
326427000546	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
326427000547	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
326427000548	FMN binding site [chemical binding]; other site
326427000549	active site
326427000550	catalytic residues [active]
326427000551	substrate binding site [chemical binding]; other site
326427000552	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
326427000553	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
326427000554	Probable transposase; Region: OrfB_IS605; pfam01385
326427000555	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
326427000556	Transposase IS200 like; Region: Y1_Tnp; pfam01797
326427000557	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
326427000558	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
326427000559	CoA binding domain; Region: CoA_binding; smart00881
326427000560	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
326427000561	Flavoprotein; Region: Flavoprotein; pfam02441
326427000562	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
326427000563	HEAT repeats; Region: HEAT_2; pfam13646
326427000564	Bacterial SH3 domain homologues; Region: SH3b; smart00287
326427000565	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
326427000566	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
326427000567	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
326427000568	Ligand binding site; other site
326427000569	Putative Catalytic site; other site
326427000570	DXD motif; other site
326427000571	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
326427000572	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427000573	S-adenosylmethionine binding site [chemical binding]; other site
326427000574	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
326427000575	active site
326427000576	homotetramer interface [polypeptide binding]; other site
326427000577	homodimer interface [polypeptide binding]; other site
326427000578	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
326427000579	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427000580	S-adenosylmethionine binding site [chemical binding]; other site
326427000581	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
326427000582	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326427000583	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427000584	active site
326427000585	phosphorylation site [posttranslational modification]
326427000586	intermolecular recognition site; other site
326427000587	dimerization interface [polypeptide binding]; other site
326427000588	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
326427000589	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
326427000590	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326427000591	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
326427000592	galactokinase; Provisional; Region: PRK05101
326427000593	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
326427000594	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427000595	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326427000596	putative substrate translocation pore; other site
326427000597	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
326427000598	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
326427000599	nucleophile elbow; other site
326427000600	ParB-like nuclease domain; Region: ParBc; pfam02195
326427000601	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
326427000602	short chain dehydrogenase; Provisional; Region: PRK06841
326427000603	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427000604	NAD(P) binding site [chemical binding]; other site
326427000605	active site
326427000606	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427000607	tellurium resistance terB-like protein; Region: terB_like; cd07177
326427000608	metal binding site [ion binding]; metal-binding site
326427000609	Tellurite resistance protein TerB; Region: TerB; pfam05099
326427000610	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
326427000611	active site
326427000612	substrate binding pocket [chemical binding]; other site
326427000613	dimer interface [polypeptide binding]; other site
326427000614	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
326427000615	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
326427000616	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
326427000617	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
326427000618	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190
326427000619	cleavage site
326427000620	active site
326427000621	substrate binding sites [chemical binding]; other site
326427000622	conserved repeat domain; Region: B_ant_repeat; TIGR01451
326427000623	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
326427000624	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
326427000625	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326427000626	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
326427000627	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
326427000628	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
326427000629	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
326427000630	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326427000631	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
326427000632	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326427000633	DNA binding residues [nucleotide binding]
326427000634	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326427000635	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326427000636	active site
326427000637	carboxylate-amine ligase; Provisional; Region: PRK13515
326427000638	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
326427000639	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
326427000640	von Willebrand factor type A domain; Region: VWA_2; pfam13519
326427000641	Protein of unknown function (DUF402); Region: DUF402; pfam04167
326427000642	Protein of unknown function DUF58; Region: DUF58; pfam01882
326427000643	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
326427000644	MoxR-like ATPases [General function prediction only]; Region: COG0714
326427000645	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427000646	Walker A motif; other site
326427000647	ATP binding site [chemical binding]; other site
326427000648	Walker B motif; other site
326427000649	arginine finger; other site
326427000650	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
326427000651	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
326427000652	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
326427000653	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
326427000654	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
326427000655	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046
326427000656	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
326427000657	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
326427000658	dimerization interface [polypeptide binding]; other site
326427000659	ATP binding site [chemical binding]; other site
326427000660	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
326427000661	dimerization interface [polypeptide binding]; other site
326427000662	ATP binding site [chemical binding]; other site
326427000663	Protein of unknown function (DUF1444); Region: DUF1444; cl02011
326427000664	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
326427000665	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
326427000666	HSP70 interaction site [polypeptide binding]; other site
326427000667	translocation protein TolB; Provisional; Region: tolB; PRK01742
326427000668	salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054
326427000669	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
326427000670	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
326427000671	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
326427000672	dimer interface [polypeptide binding]; other site
326427000673	tetramer interface [polypeptide binding]; other site
326427000674	PYR/PP interface [polypeptide binding]; other site
326427000675	TPP binding site [chemical binding]; other site
326427000676	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
326427000677	TPP-binding site; other site
326427000678	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
326427000679	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
326427000680	inhibitor-cofactor binding pocket; inhibition site
326427000681	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427000682	catalytic residue [active]
326427000683	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
326427000684	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
326427000685	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
326427000686	Response regulator receiver domain; Region: Response_reg; pfam00072
326427000687	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427000688	active site
326427000689	phosphorylation site [posttranslational modification]
326427000690	intermolecular recognition site; other site
326427000691	dimerization interface [polypeptide binding]; other site
326427000692	Helix-turn-helix domain; Region: HTH_25; pfam13413
326427000693	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
326427000694	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
326427000695	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
326427000696	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
326427000697	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
326427000698	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
326427000699	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
326427000700	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
326427000701	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
326427000702	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
326427000703	GAF domain; Region: GAF; pfam01590
326427000704	GAF domain; Region: GAF; pfam01590
326427000705	GAF domain; Region: GAF_2; pfam13185
326427000706	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427000707	GAF domain; Region: GAF_2; pfam13185
326427000708	GAF domain; Region: GAF_3; pfam13492
326427000709	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427000710	ATP binding site [chemical binding]; other site
326427000711	Mg2+ binding site [ion binding]; other site
326427000712	G-X-G motif; other site
326427000713	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326427000714	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427000715	active site
326427000716	phosphorylation site [posttranslational modification]
326427000717	intermolecular recognition site; other site
326427000718	dimerization interface [polypeptide binding]; other site
326427000719	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326427000720	DNA binding residues [nucleotide binding]
326427000721	dimerization interface [polypeptide binding]; other site
326427000722	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326427000723	active site
326427000724	ATP binding site [chemical binding]; other site
326427000725	substrate binding site [chemical binding]; other site
326427000726	activation loop (A-loop); other site
326427000727	Predicted transcriptional regulator [Transcription]; Region: COG2378
326427000728	WYL domain; Region: WYL; pfam13280
326427000729	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326427000730	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427000731	putative substrate translocation pore; other site
326427000732	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326427000733	MarR family; Region: MarR; pfam01047
326427000734	magnesium chelatase, H subunit; Region: BchH; TIGR02025
326427000735	Domain of unknown function (DUF3479); Region: DUF3479; pfam11965
326427000736	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
326427000737	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
326427000738	EVE domain; Region: EVE; pfam01878
326427000739	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326427000740	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427000741	active site
326427000742	phosphorylation site [posttranslational modification]
326427000743	intermolecular recognition site; other site
326427000744	dimerization interface [polypeptide binding]; other site
326427000745	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326427000746	DNA binding site [nucleotide binding]
326427000747	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326427000748	dimerization interface [polypeptide binding]; other site
326427000749	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427000750	dimer interface [polypeptide binding]; other site
326427000751	phosphorylation site [posttranslational modification]
326427000752	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427000753	ATP binding site [chemical binding]; other site
326427000754	Mg2+ binding site [ion binding]; other site
326427000755	G-X-G motif; other site
326427000756	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
326427000757	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
326427000758	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
326427000759	Na binding site [ion binding]; other site
326427000760	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
326427000761	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
326427000762	acyl-activating enzyme (AAE) consensus motif; other site
326427000763	putative AMP binding site [chemical binding]; other site
326427000764	putative active site [active]
326427000765	putative CoA binding site [chemical binding]; other site
326427000766	PAS domain S-box; Region: sensory_box; TIGR00229
326427000767	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427000768	putative active site [active]
326427000769	heme pocket [chemical binding]; other site
326427000770	GAF domain; Region: GAF_2; pfam13185
326427000771	GAF domain; Region: GAF; cl17456
326427000772	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427000773	dimer interface [polypeptide binding]; other site
326427000774	phosphorylation site [posttranslational modification]
326427000775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427000776	ATP binding site [chemical binding]; other site
326427000777	Mg2+ binding site [ion binding]; other site
326427000778	G-X-G motif; other site
326427000779	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427000780	Response regulator receiver domain; Region: Response_reg; pfam00072
326427000781	active site
326427000782	phosphorylation site [posttranslational modification]
326427000783	intermolecular recognition site; other site
326427000784	dimerization interface [polypeptide binding]; other site
326427000785	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
326427000786	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
326427000787	putative acyl-acceptor binding pocket; other site
326427000788	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
326427000789	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
326427000790	tetramer interface [polypeptide binding]; other site
326427000791	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427000792	catalytic residue [active]
326427000793	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
326427000794	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
326427000795	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
326427000796	tetramer interface [polypeptide binding]; other site
326427000797	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427000798	catalytic residue [active]
326427000799	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
326427000800	lipoyl attachment site [posttranslational modification]; other site
326427000801	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
326427000802	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
326427000803	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
326427000804	CpXC protein; Region: CpXC; pfam14353
326427000805	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
326427000806	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
326427000807	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
326427000808	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
326427000809	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326427000810	active site
326427000811	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326427000812	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
326427000813	putative cation:proton antiport protein; Provisional; Region: PRK10669
326427000814	TrkA-N domain; Region: TrkA_N; pfam02254
326427000815	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
326427000816	TrkA-C domain; Region: TrkA_C; pfam02080
326427000817	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
326427000818	KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592
326427000819	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
326427000820	putative active site [active]
326427000821	putative catalytic site [active]
326427000822	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326427000823	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326427000824	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
326427000825	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
326427000826	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
326427000827	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427000828	Coenzyme A binding pocket [chemical binding]; other site
326427000829	argininosuccinate lyase; Provisional; Region: PRK00855
326427000830	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
326427000831	active sites [active]
326427000832	tetramer interface [polypeptide binding]; other site
326427000833	lipoprotein LpqB; Provisional; Region: PRK13615
326427000834	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
326427000835	heterotetramer interface [polypeptide binding]; other site
326427000836	active site pocket [active]
326427000837	cleavage site
326427000838	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
326427000839	catalytic core [active]
326427000840	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427000841	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
326427000842	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
326427000843	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
326427000844	active site
326427000845	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
326427000846	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
326427000847	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
326427000848	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
326427000849	Double zinc ribbon; Region: DZR; pfam12773
326427000850	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
326427000851	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
326427000852	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326427000853	phosphopeptide binding site; other site
326427000854	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
326427000855	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
326427000856	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
326427000857	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
326427000858	Walker A/P-loop; other site
326427000859	ATP binding site [chemical binding]; other site
326427000860	Q-loop/lid; other site
326427000861	ABC transporter signature motif; other site
326427000862	Walker B; other site
326427000863	D-loop; other site
326427000864	H-loop/switch region; other site
326427000865	TOBE domain; Region: TOBE; pfam03459
326427000866	TOBE domain; Region: TOBE; pfam03459
326427000867	Transcriptional regulators [Transcription]; Region: PurR; COG1609
326427000868	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
326427000869	DNA binding site [nucleotide binding]
326427000870	domain linker motif; other site
326427000871	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
326427000872	dimerization interface [polypeptide binding]; other site
326427000873	ligand binding site [chemical binding]; other site
326427000874	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
326427000875	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
326427000876	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326427000877	P-loop; other site
326427000878	Magnesium ion binding site [ion binding]; other site
326427000879	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326427000880	Magnesium ion binding site [ion binding]; other site
326427000881	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
326427000882	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
326427000883	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
326427000884	Zn2+ binding site [ion binding]; other site
326427000885	Mg2+ binding site [ion binding]; other site
326427000886	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
326427000887	ATP cone domain; Region: ATP-cone; pfam03477
326427000888	Restriction endonuclease; Region: Mrr_cat; pfam04471
326427000889	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326427000890	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
326427000891	NAD(P) binding site [chemical binding]; other site
326427000892	homotetramer interface [polypeptide binding]; other site
326427000893	homodimer interface [polypeptide binding]; other site
326427000894	active site
326427000895	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
326427000896	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
326427000897	ATP-grasp domain; Region: ATP-grasp_4; cl17255
326427000898	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
326427000899	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
326427000900	putative RNA binding site [nucleotide binding]; other site
326427000901	acyl carrier protein; Provisional; Region: acpP; PRK00982
326427000902	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14461
326427000903	histidyl-tRNA synthetase; Region: hisS; TIGR00442
326427000904	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
326427000905	dimer interface [polypeptide binding]; other site
326427000906	motif 1; other site
326427000907	active site
326427000908	motif 2; other site
326427000909	motif 3; other site
326427000910	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
326427000911	anticodon binding site; other site
326427000912	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
326427000913	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
326427000914	Probable transposase; Region: OrfB_IS605; pfam01385
326427000915	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
326427000916	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
326427000917	Protein of unknown function DUF58; Region: DUF58; pfam01882
326427000918	B12 binding domain; Region: B12-binding_2; pfam02607
326427000919	B12 binding domain; Region: B12-binding; pfam02310
326427000920	B12 binding site [chemical binding]; other site
326427000921	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
326427000922	Cna protein B-type domain; Region: Cna_B; pfam05738
326427000923	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
326427000924	CARDB; Region: CARDB; pfam07705
326427000925	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
326427000926	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
326427000927	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
326427000928	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
326427000929	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
326427000930	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
326427000931	Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103
326427000932	Protein of unknown function DUF58; Region: DUF58; pfam01882
326427000933	von Willebrand factor type A domain; Region: VWA_2; pfam13519
326427000934	von Willebrand factor type A domain; Region: VWA_2; pfam13519
326427000935	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
326427000936	metal ion-dependent adhesion site (MIDAS); other site
326427000937	Beta-lactamase; Region: Beta-lactamase; pfam00144
326427000938	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
326427000939	Protein of unknown function, DUF393; Region: DUF393; pfam04134
326427000940	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
326427000941	hydroxyglutarate oxidase; Provisional; Region: PRK11728
326427000942	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
326427000943	nudix motif; other site
326427000944	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
326427000945	Glucokinase; Region: Glucokinase; pfam02685
326427000946	glucokinase, proteobacterial type; Region: glk; TIGR00749
326427000947	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
326427000948	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
326427000949	substrate binding site [chemical binding]; other site
326427000950	hexamer interface [polypeptide binding]; other site
326427000951	metal binding site [ion binding]; metal-binding site
326427000952	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
326427000953	tetramer (dimer of dimers) interface [polypeptide binding]; other site
326427000954	active site
326427000955	dimer interface [polypeptide binding]; other site
326427000956	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
326427000957	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
326427000958	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
326427000959	protein binding site [polypeptide binding]; other site
326427000960	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
326427000961	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
326427000962	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
326427000963	cobalamin binding residues [chemical binding]; other site
326427000964	putative BtuC binding residues; other site
326427000965	dimer interface [polypeptide binding]; other site
326427000966	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
326427000967	pyruvate kinase; Provisional; Region: PRK05826
326427000968	domain interfaces; other site
326427000969	active site
326427000970	SLBB domain; Region: SLBB; pfam10531
326427000971	comEA protein; Region: comE; TIGR01259
326427000972	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
326427000973	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
326427000974	Clp amino terminal domain; Region: Clp_N; pfam02861
326427000975	Clp amino terminal domain; Region: Clp_N; pfam02861
326427000976	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427000977	Walker A motif; other site
326427000978	ATP binding site [chemical binding]; other site
326427000979	Walker B motif; other site
326427000980	arginine finger; other site
326427000981	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427000982	Walker A motif; other site
326427000983	ATP binding site [chemical binding]; other site
326427000984	Walker B motif; other site
326427000985	arginine finger; other site
326427000986	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
326427000987	DNA primase; Validated; Region: dnaG; PRK05667
326427000988	CHC2 zinc finger; Region: zf-CHC2; cl17510
326427000989	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
326427000990	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
326427000991	active site
326427000992	metal binding site [ion binding]; metal-binding site
326427000993	interdomain interaction site; other site
326427000994	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
326427000995	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
326427000996	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
326427000997	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326427000998	FeS/SAM binding site; other site
326427000999	V4R domain; Region: V4R; cl15268
326427001000	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
326427001001	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
326427001002	RNA binding surface [nucleotide binding]; other site
326427001003	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427001004	S-adenosylmethionine binding site [chemical binding]; other site
326427001005	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
326427001006	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
326427001007	nudix motif; other site
326427001008	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
326427001009	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
326427001010	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
326427001011	Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834
326427001012	large tegument protein UL36; Provisional; Region: PHA03247
326427001013	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
326427001014	catalytic residues [active]
326427001015	dimer interface [polypeptide binding]; other site
326427001016	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
326427001017	active site
326427001018	Ap6A binding site [chemical binding]; other site
326427001019	nudix motif; other site
326427001020	metal binding site [ion binding]; metal-binding site
326427001021	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
326427001022	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
326427001023	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
326427001024	active site
326427001025	cyclase homology domain; Region: CHD; cd07302
326427001026	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
326427001027	nucleotidyl binding site; other site
326427001028	metal binding site [ion binding]; metal-binding site
326427001029	dimer interface [polypeptide binding]; other site
326427001030	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
326427001031	cyclase homology domain; Region: CHD; cd07302
326427001032	dimer interface [polypeptide binding]; other site
326427001033	nucleotidyl binding site; other site
326427001034	metal binding site [ion binding]; metal-binding site
326427001035	AAA ATPase domain; Region: AAA_16; pfam13191
326427001036	Walker A motif; other site
326427001037	ATP binding site [chemical binding]; other site
326427001038	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
326427001039	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
326427001040	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
326427001041	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
326427001042	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
326427001043	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427001044	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
326427001045	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
326427001046	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
326427001047	Walker A/P-loop; other site
326427001048	ATP binding site [chemical binding]; other site
326427001049	Q-loop/lid; other site
326427001050	ABC transporter signature motif; other site
326427001051	Walker B; other site
326427001052	D-loop; other site
326427001053	H-loop/switch region; other site
326427001054	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427001055	dimer interface [polypeptide binding]; other site
326427001056	conserved gate region; other site
326427001057	ABC-ATPase subunit interface; other site
326427001058	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
326427001059	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326427001060	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427001061	dimer interface [polypeptide binding]; other site
326427001062	conserved gate region; other site
326427001063	ABC-ATPase subunit interface; other site
326427001064	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
326427001065	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
326427001066	substrate binding pocket [chemical binding]; other site
326427001067	membrane-bound complex binding site; other site
326427001068	hinge residues; other site
326427001069	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
326427001070	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326427001071	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427001072	active site
326427001073	phosphorylation site [posttranslational modification]
326427001074	intermolecular recognition site; other site
326427001075	dimerization interface [polypeptide binding]; other site
326427001076	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326427001077	DNA binding residues [nucleotide binding]
326427001078	dimerization interface [polypeptide binding]; other site
326427001079	GAF domain; Region: GAF_3; pfam13492
326427001080	GAF domain; Region: GAF_2; pfam13185
326427001081	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427001082	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427001083	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427001084	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427001085	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326427001086	Histidine kinase; Region: HisKA_3; pfam07730
326427001087	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427001088	ATP binding site [chemical binding]; other site
326427001089	Mg2+ binding site [ion binding]; other site
326427001090	G-X-G motif; other site
326427001091	ScpA/B protein; Region: ScpA_ScpB; cl00598
326427001092	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
326427001093	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
326427001094	catalytic residues [active]
326427001095	Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858
326427001096	Predicted transcriptional regulator [Transcription]; Region: COG1959
326427001097	Transcriptional regulator; Region: Rrf2; pfam02082
326427001098	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
326427001099	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
326427001100	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
326427001101	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326427001102	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
326427001103	substrate binding site [chemical binding]; other site
326427001104	oxyanion hole (OAH) forming residues; other site
326427001105	trimer interface [polypeptide binding]; other site
326427001106	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
326427001107	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
326427001108	dimer interface [polypeptide binding]; other site
326427001109	active site
326427001110	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326427001111	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
326427001112	ligand binding site [chemical binding]; other site
326427001113	flexible hinge region; other site
326427001114	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
326427001115	non-specific DNA interactions [nucleotide binding]; other site
326427001116	DNA binding site [nucleotide binding]
326427001117	sequence specific DNA binding site [nucleotide binding]; other site
326427001118	putative cAMP binding site [chemical binding]; other site
326427001119	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
326427001120	nucleotide binding site [chemical binding]; other site
326427001121	N-acetyl-L-glutamate binding site [chemical binding]; other site
326427001122	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
326427001123	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
326427001124	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
326427001125	Protein export membrane protein; Region: SecD_SecF; cl14618
326427001126	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
326427001127	HlyD family secretion protein; Region: HlyD_3; pfam13437
326427001128	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326427001129	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
326427001130	CHAT domain; Region: CHAT; cl17868
326427001131	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427001132	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427001133	TPR motif; other site
326427001134	binding surface
326427001135	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427001136	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427001137	TPR motif; other site
326427001138	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427001139	binding surface
326427001140	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427001141	TPR motif; other site
326427001142	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427001143	binding surface
326427001144	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427001145	binding surface
326427001146	TPR motif; other site
326427001147	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427001148	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427001149	binding surface
326427001150	TPR motif; other site
326427001151	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427001152	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427001153	Tetratricopeptide repeat; Region: TPR_10; pfam13374
326427001154	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427001155	Tetratricopeptide repeat; Region: TPR_10; pfam13374
326427001156	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
326427001157	FAD dependent oxidoreductase; Region: DAO; pfam01266
326427001158	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
326427001159	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
326427001160	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
326427001161	Walker A/P-loop; other site
326427001162	ATP binding site [chemical binding]; other site
326427001163	Q-loop/lid; other site
326427001164	ABC transporter signature motif; other site
326427001165	Walker B; other site
326427001166	D-loop; other site
326427001167	H-loop/switch region; other site
326427001168	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
326427001169	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
326427001170	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
326427001171	TrkA-N domain; Region: TrkA_N; pfam02254
326427001172	TrkA-C domain; Region: TrkA_C; pfam02080
326427001173	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
326427001174	putative FMN binding site [chemical binding]; other site
326427001175	GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478
326427001176	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
326427001177	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
326427001178	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427001179	Bacterial transcriptional activator domain; Region: BTAD; smart01043
326427001180	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
326427001181	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
326427001182	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
326427001183	acyl-activating enzyme (AAE) consensus motif; other site
326427001184	acyl-activating enzyme (AAE) consensus motif; other site
326427001185	putative AMP binding site [chemical binding]; other site
326427001186	putative active site [active]
326427001187	putative CoA binding site [chemical binding]; other site
326427001188	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
326427001189	PGAP1-like protein; Region: PGAP1; pfam07819
326427001190	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326427001191	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
326427001192	catalytic site [active]
326427001193	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
326427001194	dimer interaction site [polypeptide binding]; other site
326427001195	substrate-binding tunnel; other site
326427001196	active site
326427001197	catalytic site [active]
326427001198	substrate binding site [chemical binding]; other site
326427001199	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
326427001200	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326427001201	substrate binding site [chemical binding]; other site
326427001202	oxyanion hole (OAH) forming residues; other site
326427001203	trimer interface [polypeptide binding]; other site
326427001204	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
326427001205	active site 1 [active]
326427001206	active site 2 [active]
326427001207	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
326427001208	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
326427001209	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
326427001210	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
326427001211	active site
326427001212	Zn binding site [ion binding]; other site
326427001213	CAAX protease self-immunity; Region: Abi; pfam02517
326427001214	Arsenite oxidase (Arsenite-Ox) oxidizes arsenite to the less toxic arsenate; it transfers the electrons obtained from the oxidation of arsenite towards the soluble periplasmic electron carriers cytochrome c and/or amicyanin.  Arsenite oxidase is a...; Region: MopB_Arsenite-Ox; cd02756
326427001215	arsenite oxidase, large subunit; Region: arsenite_ox_L; TIGR02693
326427001216	[3Fe-4S] binding site [ion binding]; other site
326427001217	molybdopterin cofactor binding site [chemical binding]; other site
326427001218	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
326427001219	molybdopterin cofactor binding site; other site
326427001220	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
326427001221	Small subunit of Arsenite oxidase (ArOX) family, Rieske domain; ArOX is a molybdenum/iron protein involved in the detoxification of arsenic, oxidizing it to arsenate. It consists of two subunits, a large subunit similar to members of the DMSO reductase...; Region: Rieske_ArOX_small; cd03476
326427001222	[2Fe-2S] cluster binding site [ion binding]; other site
326427001223	subunit interaction site [polypeptide binding]; other site
326427001224	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
326427001225	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
326427001226	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
326427001227	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
326427001228	putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641
326427001229	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
326427001230	carboxyltransferase (CT) interaction site; other site
326427001231	biotinylation site [posttranslational modification]; other site
326427001232	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
326427001233	FOG: CBS domain [General function prediction only]; Region: COG0517
326427001234	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
326427001235	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427001236	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
326427001237	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326427001238	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326427001239	catalytic residue [active]
326427001240	tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887
326427001241	UbiA prenyltransferase family; Region: UbiA; pfam01040
326427001242	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
326427001243	UbiA prenyltransferase family; Region: UbiA; pfam01040
326427001244	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427001245	PAS fold; Region: PAS_4; pfam08448
326427001246	putative active site [active]
326427001247	heme pocket [chemical binding]; other site
326427001248	PAS domain S-box; Region: sensory_box; TIGR00229
326427001249	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427001250	putative active site [active]
326427001251	heme pocket [chemical binding]; other site
326427001252	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427001253	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427001254	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326427001255	dimer interface [polypeptide binding]; other site
326427001256	phosphorylation site [posttranslational modification]
326427001257	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427001258	ATP binding site [chemical binding]; other site
326427001259	Mg2+ binding site [ion binding]; other site
326427001260	G-X-G motif; other site
326427001261	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
326427001262	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427001263	active site
326427001264	phosphorylation site [posttranslational modification]
326427001265	intermolecular recognition site; other site
326427001266	dimerization interface [polypeptide binding]; other site
326427001267	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
326427001268	Vacuole effluxer Atg22 like; Region: ATG22; pfam11700
326427001269	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
326427001270	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326427001271	dimerization interface [polypeptide binding]; other site
326427001272	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427001273	dimer interface [polypeptide binding]; other site
326427001274	phosphorylation site [posttranslational modification]
326427001275	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427001276	ATP binding site [chemical binding]; other site
326427001277	Mg2+ binding site [ion binding]; other site
326427001278	G-X-G motif; other site
326427001279	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326427001280	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427001281	active site
326427001282	phosphorylation site [posttranslational modification]
326427001283	intermolecular recognition site; other site
326427001284	dimerization interface [polypeptide binding]; other site
326427001285	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326427001286	DNA binding site [nucleotide binding]
326427001287	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
326427001288	aromatic arch; other site
326427001289	DCoH dimer interaction site [polypeptide binding]; other site
326427001290	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
326427001291	DCoH tetramer interaction site [polypeptide binding]; other site
326427001292	substrate binding site [chemical binding]; other site
326427001293	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
326427001294	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326427001295	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
326427001296	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326427001297	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
326427001298	FAD binding site [chemical binding]; other site
326427001299	homotetramer interface [polypeptide binding]; other site
326427001300	substrate binding pocket [chemical binding]; other site
326427001301	catalytic base [active]
326427001302	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
326427001303	catalytic core [active]
326427001304	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
326427001305	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
326427001306	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
326427001307	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
326427001308	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
326427001309	structural tetrad; other site
326427001310	FOG: WD40 repeat [General function prediction only]; Region: COG2319
326427001311	Putative esterase; Region: Esterase; pfam00756
326427001312	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
326427001313	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
326427001314	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
326427001315	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427001316	dimer interface [polypeptide binding]; other site
326427001317	conserved gate region; other site
326427001318	putative PBP binding loops; other site
326427001319	ABC-ATPase subunit interface; other site
326427001320	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
326427001321	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427001322	dimer interface [polypeptide binding]; other site
326427001323	conserved gate region; other site
326427001324	putative PBP binding loops; other site
326427001325	ABC-ATPase subunit interface; other site
326427001326	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
326427001327	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
326427001328	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
326427001329	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
326427001330	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
326427001331	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
326427001332	active site
326427001333	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427001334	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
326427001335	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
326427001336	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
326427001337	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
326427001338	Ligand binding site [chemical binding]; other site
326427001339	Electron transfer flavoprotein domain; Region: ETF; pfam01012
326427001340	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427001341	argininosuccinate synthase; Validated; Region: PRK05370
326427001342	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
326427001343	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
326427001344	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
326427001345	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427001346	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
326427001347	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
326427001348	putative active site [active]
326427001349	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
326427001350	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326427001351	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427001352	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326427001353	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
326427001354	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
326427001355	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
326427001356	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
326427001357	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
326427001358	DEAD-like helicases superfamily; Region: DEXDc; smart00487
326427001359	ATP binding site [chemical binding]; other site
326427001360	Mg++ binding site [ion binding]; other site
326427001361	motif III; other site
326427001362	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326427001363	nucleotide binding region [chemical binding]; other site
326427001364	ATP-binding site [chemical binding]; other site
326427001365	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
326427001366	RNA binding site [nucleotide binding]; other site
326427001367	Response regulator receiver domain; Region: Response_reg; pfam00072
326427001368	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427001369	active site
326427001370	phosphorylation site [posttranslational modification]
326427001371	intermolecular recognition site; other site
326427001372	dimerization interface [polypeptide binding]; other site
326427001373	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
326427001374	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326427001375	metal binding site [ion binding]; metal-binding site
326427001376	active site
326427001377	I-site; other site
326427001378	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
326427001379	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
326427001380	active site
326427001381	HIGH motif; other site
326427001382	dimer interface [polypeptide binding]; other site
326427001383	KMSKS motif; other site
326427001384	Thiamine pyrophosphokinase; Region: TPK; cd07995
326427001385	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
326427001386	active site
326427001387	dimerization interface [polypeptide binding]; other site
326427001388	thiamine binding site [chemical binding]; other site
326427001389	LysE type translocator; Region: LysE; cl00565
326427001390	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
326427001391	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427001392	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
326427001393	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
326427001394	TM-ABC transporter signature motif; other site
326427001395	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
326427001396	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
326427001397	TM-ABC transporter signature motif; other site
326427001398	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
326427001399	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
326427001400	Walker A/P-loop; other site
326427001401	ATP binding site [chemical binding]; other site
326427001402	Q-loop/lid; other site
326427001403	ABC transporter signature motif; other site
326427001404	Walker B; other site
326427001405	D-loop; other site
326427001406	H-loop/switch region; other site
326427001407	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
326427001408	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
326427001409	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
326427001410	4-alpha-glucanotransferase; Provisional; Region: PRK14508
326427001411	recombination protein F; Reviewed; Region: recF; PRK00064
326427001412	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
326427001413	Walker A/P-loop; other site
326427001414	ATP binding site [chemical binding]; other site
326427001415	Q-loop/lid; other site
326427001416	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
326427001417	ABC transporter signature motif; other site
326427001418	Walker B; other site
326427001419	D-loop; other site
326427001420	H-loop/switch region; other site
326427001421	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
326427001422	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
326427001423	homotetramer interface [polypeptide binding]; other site
326427001424	FMN binding site [chemical binding]; other site
326427001425	homodimer contacts [polypeptide binding]; other site
326427001426	putative active site [active]
326427001427	putative substrate binding site [chemical binding]; other site
326427001428	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
326427001429	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
326427001430	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
326427001431	Beta-lactamase; Region: Beta-lactamase; pfam00144
326427001432	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
326427001433	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
326427001434	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
326427001435	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
326427001436	Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403
326427001437	putative active site [active]
326427001438	putative metal binding site [ion binding]; other site
326427001439	Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403
326427001440	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326427001441	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326427001442	dimerization interface [polypeptide binding]; other site
326427001443	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427001444	dimer interface [polypeptide binding]; other site
326427001445	phosphorylation site [posttranslational modification]
326427001446	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427001447	ATP binding site [chemical binding]; other site
326427001448	Mg2+ binding site [ion binding]; other site
326427001449	G-X-G motif; other site
326427001450	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
326427001451	catalytic residues [active]
326427001452	dimer interface [polypeptide binding]; other site
326427001453	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
326427001454	dimer interface [polypeptide binding]; other site
326427001455	ligand binding site [chemical binding]; other site
326427001456	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
326427001457	additional DNA contacts [nucleotide binding]; other site
326427001458	mismatch recognition site; other site
326427001459	active site
326427001460	zinc binding site [ion binding]; other site
326427001461	DNA intercalation site [nucleotide binding]; other site
326427001462	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
326427001463	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
326427001464	cofactor binding site; other site
326427001465	DNA binding site [nucleotide binding]
326427001466	substrate interaction site [chemical binding]; other site
326427001467	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
326427001468	CAAX protease self-immunity; Region: Abi; pfam02517
326427001469	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
326427001470	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
326427001471	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326427001472	active site
326427001473	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427001474	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
326427001475	Coenzyme A binding pocket [chemical binding]; other site
326427001476	Methyltransferase domain; Region: Methyltransf_26; pfam13659
326427001477	Acylphosphatase; Region: Acylphosphatase; pfam00708
326427001478	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
326427001479	HypF finger; Region: zf-HYPF; pfam07503
326427001480	HypF finger; Region: zf-HYPF; pfam07503
326427001481	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
326427001482	Protein of unknown function (DUF1641); Region: DUF1641; pfam07849
326427001483	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
326427001484	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
326427001485	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
326427001486	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
326427001487	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
326427001488	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
326427001489	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
326427001490	nickel binding site [ion binding]; other site
326427001491	NifU-like domain; Region: NifU; cl00484
326427001492	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
326427001493	iron-sulfur cluster [ion binding]; other site
326427001494	[2Fe-2S] cluster binding site [ion binding]; other site
326427001495	HupF/HypC family; Region: HupF_HypC; pfam01455
326427001496	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
326427001497	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
326427001498	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
326427001499	dimerization interface [polypeptide binding]; other site
326427001500	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
326427001501	ATP binding site [chemical binding]; other site
326427001502	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
326427001503	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326427001504	active site
326427001505	HIGH motif; other site
326427001506	nucleotide binding site [chemical binding]; other site
326427001507	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326427001508	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
326427001509	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326427001510	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326427001511	active site
326427001512	KMSKS motif; other site
326427001513	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
326427001514	tRNA binding surface [nucleotide binding]; other site
326427001515	Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264
326427001516	Calx-beta domain; Region: Calx-beta; cl02522
326427001517	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326427001518	dimerization interface [polypeptide binding]; other site
326427001519	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
326427001520	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427001521	putative active site [active]
326427001522	heme pocket [chemical binding]; other site
326427001523	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
326427001524	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427001525	ATP binding site [chemical binding]; other site
326427001526	Mg2+ binding site [ion binding]; other site
326427001527	G-X-G motif; other site
326427001528	GAF domain; Region: GAF; pfam01590
326427001529	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427001530	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427001531	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427001532	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
326427001533	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427001534	putative active site [active]
326427001535	heme pocket [chemical binding]; other site
326427001536	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427001537	dimer interface [polypeptide binding]; other site
326427001538	phosphorylation site [posttranslational modification]
326427001539	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427001540	ATP binding site [chemical binding]; other site
326427001541	Mg2+ binding site [ion binding]; other site
326427001542	G-X-G motif; other site
326427001543	GAF domain; Region: GAF_3; pfam13492
326427001544	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427001545	GAF domain; Region: GAF; pfam01590
326427001546	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
326427001547	cyclase homology domain; Region: CHD; cd07302
326427001548	nucleotidyl binding site; other site
326427001549	metal binding site [ion binding]; metal-binding site
326427001550	dimer interface [polypeptide binding]; other site
326427001551	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
326427001552	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
326427001553	ring oligomerisation interface [polypeptide binding]; other site
326427001554	ATP/Mg binding site [chemical binding]; other site
326427001555	stacking interactions; other site
326427001556	hinge regions; other site
326427001557	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
326427001558	oligomerisation interface [polypeptide binding]; other site
326427001559	mobile loop; other site
326427001560	roof hairpin; other site
326427001561	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
326427001562	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
326427001563	putative Zn2+ binding site [ion binding]; other site
326427001564	putative DNA binding site [nucleotide binding]; other site
326427001565	dimerization interface [polypeptide binding]; other site
326427001566	PBP superfamily domain; Region: PBP_like_2; cl17296
326427001567	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
326427001568	HAMP domain; Region: HAMP; pfam00672
326427001569	dimerization interface [polypeptide binding]; other site
326427001570	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427001571	dimer interface [polypeptide binding]; other site
326427001572	phosphorylation site [posttranslational modification]
326427001573	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427001574	ATP binding site [chemical binding]; other site
326427001575	Mg2+ binding site [ion binding]; other site
326427001576	G-X-G motif; other site
326427001577	Response regulator receiver domain; Region: Response_reg; pfam00072
326427001578	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427001579	active site
326427001580	phosphorylation site [posttranslational modification]
326427001581	intermolecular recognition site; other site
326427001582	dimerization interface [polypeptide binding]; other site
326427001583	Trm112p-like protein; Region: Trm112p; pfam03966
326427001584	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427001585	S-adenosylmethionine binding site [chemical binding]; other site
326427001586	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
326427001587	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
326427001588	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326427001589	YceI-like domain; Region: YceI; pfam04264
326427001590	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
326427001591	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
326427001592	catalytic residues [active]
326427001593	protein-export membrane protein SecD; Region: secD; TIGR01129
326427001594	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
326427001595	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
326427001596	Protein export membrane protein; Region: SecD_SecF; cl14618
326427001597	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
326427001598	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
326427001599	DNA protecting protein DprA; Region: dprA; TIGR00732
326427001600	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
326427001601	nudix motif; other site
326427001602	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
326427001603	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
326427001604	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
326427001605	putative dimerization interface [polypeptide binding]; other site
326427001606	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
326427001607	4Fe-4S binding domain; Region: Fer4; pfam00037
326427001608	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
326427001609	This CD includes the respiratory arsenate reductase, As(V), catalytic subunit (ArrA) and other related proteins. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_Arsenate-R; cd02757
326427001610	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
326427001611	putative [Fe4-S4] binding site [ion binding]; other site
326427001612	putative molybdopterin cofactor binding site [chemical binding]; other site
326427001613	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
326427001614	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
326427001615	putative molybdopterin cofactor binding site; other site
326427001616	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
326427001617	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
326427001618	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
326427001619	substrate binding pocket [chemical binding]; other site
326427001620	membrane-bound complex binding site; other site
326427001621	hinge residues; other site
326427001622	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
326427001623	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427001624	Walker A motif; other site
326427001625	ATP binding site [chemical binding]; other site
326427001626	Walker B motif; other site
326427001627	Peptidase family M41; Region: Peptidase_M41; pfam01434
326427001628	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
326427001629	dimer interface [polypeptide binding]; other site
326427001630	FMN binding site [chemical binding]; other site
326427001631	NADPH bind site [chemical binding]; other site
326427001632	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
326427001633	PUCC protein; Region: PUCC; pfam03209
326427001634	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427001635	putative substrate translocation pore; other site
326427001636	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
326427001637	Thioredoxin; Region: Thioredoxin_4; pfam13462
326427001638	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
326427001639	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
326427001640	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
326427001641	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
326427001642	Walker A/P-loop; other site
326427001643	ATP binding site [chemical binding]; other site
326427001644	Q-loop/lid; other site
326427001645	ABC transporter signature motif; other site
326427001646	Walker B; other site
326427001647	D-loop; other site
326427001648	H-loop/switch region; other site
326427001649	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
326427001650	dimer interface [polypeptide binding]; other site
326427001651	catalytic triad [active]
326427001652	peroxidatic and resolving cysteines [active]
326427001653	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
326427001654	rRNA interaction site [nucleotide binding]; other site
326427001655	S8 interaction site; other site
326427001656	putative laminin-1 binding site; other site
326427001657	elongation factor Ts; Reviewed; Region: tsf; PRK12332
326427001658	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
326427001659	Elongation factor TS; Region: EF_TS; pfam00889
326427001660	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
326427001661	putative nucleotide binding site [chemical binding]; other site
326427001662	uridine monophosphate binding site [chemical binding]; other site
326427001663	homohexameric interface [polypeptide binding]; other site
326427001664	ribosome recycling factor; Reviewed; Region: frr; PRK00083
326427001665	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
326427001666	hinge region; other site
326427001667	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
326427001668	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
326427001669	catalytic residue [active]
326427001670	putative FPP diphosphate  binding site; other site
326427001671	putative FPP binding hydrophobic cleft; other site
326427001672	dimer interface [polypeptide binding]; other site
326427001673	putative IPP diphosphate binding site; other site
326427001674	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
326427001675	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
326427001676	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
326427001677	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
326427001678	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
326427001679	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
326427001680	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
326427001681	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
326427001682	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
326427001683	active site
326427001684	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
326427001685	protein binding site [polypeptide binding]; other site
326427001686	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
326427001687	putative substrate binding region [chemical binding]; other site
326427001688	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
326427001689	Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410
326427001690	BioY family; Region: BioY; pfam02632
326427001691	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
326427001692	active site residue [active]
326427001693	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
326427001694	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
326427001695	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
326427001696	ApbE family; Region: ApbE; pfam02424
326427001697	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
326427001698	Haem-binding domain; Region: Haem_bd; pfam14376
326427001699	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326427001700	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427001701	active site
326427001702	phosphorylation site [posttranslational modification]
326427001703	intermolecular recognition site; other site
326427001704	dimerization interface [polypeptide binding]; other site
326427001705	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326427001706	DNA binding site [nucleotide binding]
326427001707	Predicted membrane protein [Function unknown]; Region: COG3212
326427001708	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
326427001709	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427001710	dimer interface [polypeptide binding]; other site
326427001711	phosphorylation site [posttranslational modification]
326427001712	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427001713	ATP binding site [chemical binding]; other site
326427001714	Mg2+ binding site [ion binding]; other site
326427001715	G-X-G motif; other site
326427001716	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
326427001717	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
326427001718	dimer interface [polypeptide binding]; other site
326427001719	active site
326427001720	CoA binding pocket [chemical binding]; other site
326427001721	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427001722	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
326427001723	NAD(P) binding site [chemical binding]; other site
326427001724	active site
326427001725	peptide synthase; Provisional; Region: PRK09274
326427001726	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910
326427001727	acyl-activating enzyme (AAE) consensus motif; other site
326427001728	putative AMP binding site [chemical binding]; other site
326427001729	putative active site [active]
326427001730	putative CoA binding site [chemical binding]; other site
326427001731	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
326427001732	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
326427001733	haloalkane dehalogenase; Provisional; Region: PRK03204
326427001734	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
326427001735	Response regulator receiver domain; Region: Response_reg; pfam00072
326427001736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427001737	active site
326427001738	phosphorylation site [posttranslational modification]
326427001739	intermolecular recognition site; other site
326427001740	dimerization interface [polypeptide binding]; other site
326427001741	PAS domain S-box; Region: sensory_box; TIGR00229
326427001742	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427001743	putative active site [active]
326427001744	heme pocket [chemical binding]; other site
326427001745	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
326427001746	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326427001747	metal binding site [ion binding]; metal-binding site
326427001748	active site
326427001749	I-site; other site
326427001750	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
326427001751	Response regulator receiver domain; Region: Response_reg; pfam00072
326427001752	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427001753	active site
326427001754	phosphorylation site [posttranslational modification]
326427001755	intermolecular recognition site; other site
326427001756	dimerization interface [polypeptide binding]; other site
326427001757	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
326427001758	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427001759	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
326427001760	putative active site [active]
326427001761	heme pocket [chemical binding]; other site
326427001762	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427001763	dimer interface [polypeptide binding]; other site
326427001764	phosphorylation site [posttranslational modification]
326427001765	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427001766	ATP binding site [chemical binding]; other site
326427001767	Mg2+ binding site [ion binding]; other site
326427001768	G-X-G motif; other site
326427001769	putative diguanylate cyclase; Provisional; Region: PRK09776
326427001770	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
326427001771	Protein of unknown function (DUF524); Region: DUF524; pfam04411
326427001772	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
326427001773	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
326427001774	oligomer interface [polypeptide binding]; other site
326427001775	metal binding site [ion binding]; metal-binding site
326427001776	metal binding site [ion binding]; metal-binding site
326427001777	putative Cl binding site [ion binding]; other site
326427001778	aspartate ring; other site
326427001779	basic sphincter; other site
326427001780	hydrophobic gate; other site
326427001781	periplasmic entrance; other site
326427001782	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427001783	Coenzyme A binding pocket [chemical binding]; other site
326427001784	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
326427001785	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
326427001786	inhibitor-cofactor binding pocket; inhibition site
326427001787	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427001788	catalytic residue [active]
326427001789	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
326427001790	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
326427001791	active site
326427001792	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
326427001793	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
326427001794	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
326427001795	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
326427001796	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
326427001797	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
326427001798	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
326427001799	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
326427001800	CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895
326427001801	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693
326427001802	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
326427001803	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
326427001804	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909
326427001805	Predicted transcriptional regulator [Transcription]; Region: COG2378
326427001806	HTH domain; Region: HTH_11; cl17392
326427001807	WYL domain; Region: WYL; pfam13280
326427001808	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
326427001809	putative DNA binding site [nucleotide binding]; other site
326427001810	putative Zn2+ binding site [ion binding]; other site
326427001811	magnesium chelatase subunit H; Provisional; Region: PRK12493
326427001812	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
326427001813	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
326427001814	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
326427001815	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326427001816	P-loop; other site
326427001817	Magnesium ion binding site [ion binding]; other site
326427001818	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
326427001819	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
326427001820	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427001821	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
326427001822	ATP-NAD kinase; Region: NAD_kinase; pfam01513
326427001823	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
326427001824	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
326427001825	E3 interaction surface; other site
326427001826	lipoyl attachment site [posttranslational modification]; other site
326427001827	e3 binding domain; Region: E3_binding; pfam02817
326427001828	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
326427001829	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
326427001830	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
326427001831	alpha subunit interface [polypeptide binding]; other site
326427001832	TPP binding site [chemical binding]; other site
326427001833	heterodimer interface [polypeptide binding]; other site
326427001834	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
326427001835	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
326427001836	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
326427001837	tetramer interface [polypeptide binding]; other site
326427001838	TPP-binding site [chemical binding]; other site
326427001839	heterodimer interface [polypeptide binding]; other site
326427001840	phosphorylation loop region [posttranslational modification]
326427001841	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
326427001842	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
326427001843	active site
326427001844	substrate binding site [chemical binding]; other site
326427001845	metal binding site [ion binding]; metal-binding site
326427001846	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
326427001847	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
326427001848	Walker A; other site
326427001849	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
326427001850	B12 binding site [chemical binding]; other site
326427001851	cobalt ligand [ion binding]; other site
326427001852	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
326427001853	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
326427001854	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
326427001855	DNA binding site [nucleotide binding]
326427001856	Bacterial transcriptional activator domain; Region: BTAD; smart01043
326427001857	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427001858	binding surface
326427001859	TPR motif; other site
326427001860	Uncharacterized conserved protein [Function unknown]; Region: COG1739
326427001861	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
326427001862	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
326427001863	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
326427001864	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
326427001865	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
326427001866	putative acyl-acceptor binding pocket; other site
326427001867	SCP-2 sterol transfer family; Region: SCP2; cl01225
326427001868	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
326427001869	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
326427001870	putative active site [active]
326427001871	substrate binding site [chemical binding]; other site
326427001872	putative cosubstrate binding site; other site
326427001873	catalytic site [active]
326427001874	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
326427001875	substrate binding site [chemical binding]; other site
326427001876	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242
326427001877	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
326427001878	putative NAD(P) binding site [chemical binding]; other site
326427001879	catalytic Zn binding site [ion binding]; other site
326427001880	structural Zn binding site [ion binding]; other site
326427001881	Response regulator receiver domain; Region: Response_reg; pfam00072
326427001882	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427001883	active site
326427001884	phosphorylation site [posttranslational modification]
326427001885	intermolecular recognition site; other site
326427001886	dimerization interface [polypeptide binding]; other site
326427001887	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
326427001888	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326427001889	metal binding site [ion binding]; metal-binding site
326427001890	active site
326427001891	I-site; other site
326427001892	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
326427001893	TPR repeat; Region: TPR_11; pfam13414
326427001894	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427001895	binding surface
326427001896	TPR motif; other site
326427001897	TPR repeat; Region: TPR_11; pfam13414
326427001898	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427001899	binding surface
326427001900	TPR motif; other site
326427001901	TPR repeat; Region: TPR_11; pfam13414
326427001902	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427001903	binding surface
326427001904	TPR motif; other site
326427001905	TPR repeat; Region: TPR_11; pfam13414
326427001906	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427001907	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427001908	TPR motif; other site
326427001909	binding surface
326427001910	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
326427001911	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427001912	binding surface
326427001913	TPR motif; other site
326427001914	Uncharacterized conserved protein [Function unknown]; Region: COG1262
326427001915	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
326427001916	SEC-C motif; Region: SEC-C; pfam02810
326427001917	GAF domain; Region: GAF; pfam01590
326427001918	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427001919	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427001920	GAF domain; Region: GAF_3; pfam13492
326427001921	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427001922	dimer interface [polypeptide binding]; other site
326427001923	phosphorylation site [posttranslational modification]
326427001924	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427001925	ATP binding site [chemical binding]; other site
326427001926	Mg2+ binding site [ion binding]; other site
326427001927	G-X-G motif; other site
326427001928	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
326427001929	cofactor binding site; other site
326427001930	metal binding site [ion binding]; metal-binding site
326427001931	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
326427001932	Predicted permease [General function prediction only]; Region: COG2985
326427001933	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
326427001934	TrkA-C domain; Region: TrkA_C; pfam02080
326427001935	TrkA-C domain; Region: TrkA_C; pfam02080
326427001936	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
326427001937	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
326427001938	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
326427001939	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
326427001940	DsrE/DsrF-like family; Region: DrsE; pfam02635
326427001941	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
326427001942	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
326427001943	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
326427001944	Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269
326427001945	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
326427001946	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
326427001947	putative metal binding site [ion binding]; other site
326427001948	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
326427001949	active site
326427001950	transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345
326427001951	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
326427001952	classical (c) SDRs; Region: SDR_c; cd05233
326427001953	NAD(P) binding site [chemical binding]; other site
326427001954	active site
326427001955	PAS domain S-box; Region: sensory_box; TIGR00229
326427001956	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427001957	putative active site [active]
326427001958	PAS fold; Region: PAS_4; pfam08448
326427001959	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
326427001960	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326427001961	metal binding site [ion binding]; metal-binding site
326427001962	active site
326427001963	I-site; other site
326427001964	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
326427001965	circadian clock protein KaiC; Reviewed; Region: PRK09302
326427001966	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
326427001967	Walker A motif; other site
326427001968	ATP binding site [chemical binding]; other site
326427001969	Walker B motif; other site
326427001970	recA bacterial DNA recombination protein; Region: RecA; cl17211
326427001971	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
326427001972	Walker A motif; other site
326427001973	ATP binding site [chemical binding]; other site
326427001974	Walker B motif; other site
326427001975	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
326427001976	tetramer interface [polypeptide binding]; other site
326427001977	dimer interface [polypeptide binding]; other site
326427001978	PAS domain S-box; Region: sensory_box; TIGR00229
326427001979	PAS domain; Region: PAS; smart00091
326427001980	putative active site [active]
326427001981	PAS fold; Region: PAS_4; pfam08448
326427001982	methionine gamma-lyase; Validated; Region: PRK07049
326427001983	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
326427001984	homodimer interface [polypeptide binding]; other site
326427001985	substrate-cofactor binding pocket; other site
326427001986	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427001987	catalytic residue [active]
326427001988	Protein of unknown function (DUF445); Region: DUF445; pfam04286
326427001989	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
326427001990	Mechanosensitive ion channel; Region: MS_channel; pfam00924
326427001991	CAAX protease self-immunity; Region: Abi; pfam02517
326427001992	Predicted integral membrane protein [Function unknown]; Region: COG5658
326427001993	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
326427001994	SdpI/YhfL protein family; Region: SdpI; pfam13630
326427001995	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
326427001996	dimerization interface [polypeptide binding]; other site
326427001997	putative DNA binding site [nucleotide binding]; other site
326427001998	putative Zn2+ binding site [ion binding]; other site
326427001999	polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132
326427002000	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
326427002001	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
326427002002	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
326427002003	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
326427002004	NAD(P) binding site [chemical binding]; other site
326427002005	homotetramer interface [polypeptide binding]; other site
326427002006	homodimer interface [polypeptide binding]; other site
326427002007	active site
326427002008	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
326427002009	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
326427002010	active site
326427002011	metal binding site [ion binding]; metal-binding site
326427002012	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
326427002013	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
326427002014	TPP-binding site [chemical binding]; other site
326427002015	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
326427002016	PYR/PP interface [polypeptide binding]; other site
326427002017	dimer interface [polypeptide binding]; other site
326427002018	TPP binding site [chemical binding]; other site
326427002019	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
326427002020	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
326427002021	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
326427002022	active site
326427002023	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
326427002024	active site
326427002025	intersubunit interactions; other site
326427002026	catalytic residue [active]
326427002027	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427002028	NAD(P) binding site [chemical binding]; other site
326427002029	active site
326427002030	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
326427002031	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
326427002032	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
326427002033	Phosphoglycerate kinase; Region: PGK; pfam00162
326427002034	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
326427002035	substrate binding site [chemical binding]; other site
326427002036	hinge regions; other site
326427002037	ADP binding site [chemical binding]; other site
326427002038	catalytic site [active]
326427002039	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
326427002040	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
326427002041	trmE is a tRNA modification GTPase; Region: trmE; cd04164
326427002042	G1 box; other site
326427002043	GTP/Mg2+ binding site [chemical binding]; other site
326427002044	Switch I region; other site
326427002045	G2 box; other site
326427002046	Switch II region; other site
326427002047	G3 box; other site
326427002048	G4 box; other site
326427002049	G5 box; other site
326427002050	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
326427002051	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
326427002052	Clp protease; Region: CLP_protease; pfam00574
326427002053	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
326427002054	oligomer interface [polypeptide binding]; other site
326427002055	active site residues [active]
326427002056	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
326427002057	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427002058	putative active site [active]
326427002059	heme pocket [chemical binding]; other site
326427002060	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427002061	dimer interface [polypeptide binding]; other site
326427002062	phosphorylation site [posttranslational modification]
326427002063	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427002064	ATP binding site [chemical binding]; other site
326427002065	Mg2+ binding site [ion binding]; other site
326427002066	G-X-G motif; other site
326427002067	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427002068	Response regulator receiver domain; Region: Response_reg; pfam00072
326427002069	active site
326427002070	phosphorylation site [posttranslational modification]
326427002071	intermolecular recognition site; other site
326427002072	dimerization interface [polypeptide binding]; other site
326427002073	Response regulator receiver domain; Region: Response_reg; pfam00072
326427002074	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427002075	active site
326427002076	phosphorylation site [posttranslational modification]
326427002077	intermolecular recognition site; other site
326427002078	dimerization interface [polypeptide binding]; other site
326427002079	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
326427002080	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
326427002081	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
326427002082	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
326427002083	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
326427002084	putative active site [active]
326427002085	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
326427002086	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
326427002087	SmpB-tmRNA interface; other site
326427002088	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427002089	S-adenosylmethionine binding site [chemical binding]; other site
326427002090	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
326427002091	CoenzymeA binding site [chemical binding]; other site
326427002092	subunit interaction site [polypeptide binding]; other site
326427002093	PHB binding site; other site
326427002094	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
326427002095	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
326427002096	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
326427002097	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
326427002098	Walker A/P-loop; other site
326427002099	ATP binding site [chemical binding]; other site
326427002100	Q-loop/lid; other site
326427002101	ABC transporter signature motif; other site
326427002102	Walker B; other site
326427002103	D-loop; other site
326427002104	H-loop/switch region; other site
326427002105	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
326427002106	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326427002107	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
326427002108	NAD(P) binding pocket [chemical binding]; other site
326427002109	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
326427002110	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
326427002111	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
326427002112	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
326427002113	binding surface
326427002114	LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186
326427002115	phosphate binding site [ion binding]; other site
326427002116	dimer interface [polypeptide binding]; other site
326427002117	substrate binding site [chemical binding]; other site
326427002118	2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552
326427002119	Predicted permeases [General function prediction only]; Region: RarD; COG2962
326427002120	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326427002121	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002122	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002123	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002124	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326427002125	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002126	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002127	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002128	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002129	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002130	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326427002131	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002132	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002133	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002134	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002135	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002136	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326427002137	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326427002138	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002139	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326427002140	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002141	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002142	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002143	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002144	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326427002145	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002146	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326427002147	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326427002148	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002149	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002150	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002151	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002152	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326427002153	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326427002154	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002155	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326427002156	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002157	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326427002158	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002159	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326427002160	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326427002161	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002162	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326427002163	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002164	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002165	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002166	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002167	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002168	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002169	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002170	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002171	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002172	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
326427002173	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326427002174	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326427002175	primosomal protein N' Region: priA; TIGR00595
326427002176	ATP binding site [chemical binding]; other site
326427002177	putative Mg++ binding site [ion binding]; other site
326427002178	helicase superfamily c-terminal domain; Region: HELICc; smart00490
326427002179	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
326427002180	5S rRNA interface [nucleotide binding]; other site
326427002181	CTC domain interface [polypeptide binding]; other site
326427002182	L16 interface [polypeptide binding]; other site
326427002183	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
326427002184	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
326427002185	DXD motif; other site
326427002186	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
326427002187	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
326427002188	Peptidase family C25; Region: Peptidase_C25; pfam01364
326427002189	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
326427002190	Trp docking motif [polypeptide binding]; other site
326427002191	active site
326427002192	PQQ-like domain; Region: PQQ_2; pfam13360
326427002193	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
326427002194	Interdomain contacts; other site
326427002195	Cytokine receptor motif; other site
326427002196	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326427002197	non-specific DNA binding site [nucleotide binding]; other site
326427002198	salt bridge; other site
326427002199	sequence-specific DNA binding site [nucleotide binding]; other site
326427002200	Predicted ATPase [General function prediction only]; Region: COG3903
326427002201	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
326427002202	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
326427002203	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
326427002204	CpXC protein; Region: CpXC; pfam14353
326427002205	CHAT domain; Region: CHAT; pfam12770
326427002206	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
326427002207	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
326427002208	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
326427002209	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
326427002210	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
326427002211	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
326427002212	putative active site; other site
326427002213	catalytic triad [active]
326427002214	putative dimer interface [polypeptide binding]; other site
326427002215	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
326427002216	putative active site pocket [active]
326427002217	dimerization interface [polypeptide binding]; other site
326427002218	putative catalytic residue [active]
326427002219	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
326427002220	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326427002221	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427002222	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326427002223	putative substrate translocation pore; other site
326427002224	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
326427002225	active site
326427002226	catalytic triad [active]
326427002227	oxyanion hole [active]
326427002228	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
326427002229	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
326427002230	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
326427002231	Phosphotransferase enzyme family; Region: APH; pfam01636
326427002232	active site
326427002233	substrate binding site [chemical binding]; other site
326427002234	ATP binding site [chemical binding]; other site
326427002235	Bacterial Ig-like domain; Region: Big_5; pfam13205
326427002236	Bacterial Ig-like domain; Region: Big_5; pfam13205
326427002237	Bacterial Ig-like domain; Region: Big_5; pfam13205
326427002238	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
326427002239	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
326427002240	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
326427002241	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
326427002242	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
326427002243	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
326427002244	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
326427002245	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
326427002246	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326427002247	active site
326427002248	HIGH motif; other site
326427002249	nucleotide binding site [chemical binding]; other site
326427002250	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
326427002251	active site
326427002252	KMSKS motif; other site
326427002253	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
326427002254	tRNA binding surface [nucleotide binding]; other site
326427002255	anticodon binding site; other site
326427002256	AAA ATPase domain; Region: AAA_16; pfam13191
326427002257	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
326427002258	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
326427002259	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
326427002260	metal ion-dependent adhesion site (MIDAS); other site
326427002261	Putative zinc-finger; Region: zf-HC2; pfam13490
326427002262	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
326427002263	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
326427002264	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
326427002265	dimer interface [polypeptide binding]; other site
326427002266	active site
326427002267	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
326427002268	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427002269	dimer interface [polypeptide binding]; other site
326427002270	conserved gate region; other site
326427002271	putative PBP binding loops; other site
326427002272	ABC-ATPase subunit interface; other site
326427002273	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
326427002274	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427002275	dimer interface [polypeptide binding]; other site
326427002276	conserved gate region; other site
326427002277	putative PBP binding loops; other site
326427002278	ABC-ATPase subunit interface; other site
326427002279	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
326427002280	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
326427002281	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326427002282	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
326427002283	MarR family; Region: MarR_2; cl17246
326427002284	H+ Antiporter protein; Region: 2A0121; TIGR00900
326427002285	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427002286	putative substrate translocation pore; other site
326427002287	Sulfatase; Region: Sulfatase; cl17466
326427002288	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
326427002289	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
326427002290	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427002291	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
326427002292	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427002293	ATP binding site [chemical binding]; other site
326427002294	Mg2+ binding site [ion binding]; other site
326427002295	G-X-G motif; other site
326427002296	Transposase IS200 like; Region: Y1_Tnp; pfam01797
326427002297	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
326427002298	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
326427002299	Probable transposase; Region: OrfB_IS605; pfam01385
326427002300	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
326427002301	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
326427002302	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194
326427002303	putative active site [active]
326427002304	metal binding site [ion binding]; metal-binding site
326427002305	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326427002306	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326427002307	active site
326427002308	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
326427002309	dimerization interface [polypeptide binding]; other site
326427002310	putative DNA binding site [nucleotide binding]; other site
326427002311	putative Zn2+ binding site [ion binding]; other site
326427002312	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
326427002313	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
326427002314	Sulfate transporter family; Region: Sulfate_transp; pfam00916
326427002315	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
326427002316	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
326427002317	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
326427002318	putative substrate binding site [chemical binding]; other site
326427002319	putative ATP binding site [chemical binding]; other site
326427002320	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
326427002321	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
326427002322	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427002323	S-adenosylmethionine binding site [chemical binding]; other site
326427002324	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326427002325	classical (c) SDRs; Region: SDR_c; cd05233
326427002326	NAD(P) binding site [chemical binding]; other site
326427002327	active site
326427002328	HD domain; Region: HD; pfam01966
326427002329	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
326427002330	Domain of unknown function DUF20; Region: UPF0118; pfam01594
326427002331	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
326427002332	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326427002333	non-specific DNA binding site [nucleotide binding]; other site
326427002334	salt bridge; other site
326427002335	sequence-specific DNA binding site [nucleotide binding]; other site
326427002336	Cupin domain; Region: Cupin_2; pfam07883
326427002337	Double zinc ribbon; Region: DZR; pfam12773
326427002338	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
326427002339	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
326427002340	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326427002341	phosphopeptide binding site; other site
326427002342	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326427002343	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
326427002344	phosphopeptide binding site; other site
326427002345	The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955
326427002346	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
326427002347	Walker A/P-loop; other site
326427002348	ATP binding site [chemical binding]; other site
326427002349	Q-loop/lid; other site
326427002350	ABC transporter signature motif; other site
326427002351	Walker B; other site
326427002352	D-loop; other site
326427002353	H-loop/switch region; other site
326427002354	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
326427002355	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
326427002356	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
326427002357	Protein phosphatase 2C; Region: PP2C; pfam00481
326427002358	active site
326427002359	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
326427002360	Double zinc ribbon; Region: DZR; pfam12773
326427002361	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
326427002362	Protein phosphatase 2C; Region: PP2C; pfam00481
326427002363	active site
326427002364	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
326427002365	Double zinc ribbon; Region: DZR; pfam12773
326427002366	Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714
326427002367	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326427002368	active site
326427002369	ATP binding site [chemical binding]; other site
326427002370	substrate binding site [chemical binding]; other site
326427002371	activation loop (A-loop); other site
326427002372	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
326427002373	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
326427002374	metal ion-dependent adhesion site (MIDAS); other site
326427002375	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
326427002376	Double zinc ribbon; Region: DZR; pfam12773
326427002377	Double zinc ribbon; Region: DZR; pfam12773
326427002378	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
326427002379	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
326427002380	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
326427002381	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326427002382	phosphopeptide binding site; other site
326427002383	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
326427002384	metal ion-dependent adhesion site (MIDAS); other site
326427002385	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427002386	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
326427002387	Walker A motif; other site
326427002388	ATP binding site [chemical binding]; other site
326427002389	Walker B motif; other site
326427002390	arginine finger; other site
326427002391	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
326427002392	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326427002393	motif II; other site
326427002394	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
326427002395	active site
326427002396	purine nucleoside phosphorylase; Provisional; Region: PRK08202
326427002397	Bacterial PH domain; Region: DUF304; pfam03703
326427002398	Short C-terminal domain; Region: SHOCT; pfam09851
326427002399	Recombination protein O N terminal; Region: RecO_N; pfam11967
326427002400	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
326427002401	Recombination protein O C terminal; Region: RecO_C; pfam02565
326427002402	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
326427002403	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
326427002404	Walker A/P-loop; other site
326427002405	ATP binding site [chemical binding]; other site
326427002406	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
326427002407	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
326427002408	ABC transporter signature motif; other site
326427002409	Walker B; other site
326427002410	D-loop; other site
326427002411	H-loop/switch region; other site
326427002412	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
326427002413	active site
326427002414	nucleotide binding site [chemical binding]; other site
326427002415	HIGH motif; other site
326427002416	KMSKS motif; other site
326427002417	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
326427002418	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
326427002419	Zn2+ binding site [ion binding]; other site
326427002420	Mg2+ binding site [ion binding]; other site
326427002421	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
326427002422	shikimate kinase; Reviewed; Region: aroK; PRK00131
326427002423	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
326427002424	ADP binding site [chemical binding]; other site
326427002425	magnesium binding site [ion binding]; other site
326427002426	putative shikimate binding site; other site
326427002427	acylphosphatase; Provisional; Region: PRK14444
326427002428	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
326427002429	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
326427002430	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326427002431	ligand binding site [chemical binding]; other site
326427002432	flexible hinge region; other site
326427002433	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
326427002434	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
326427002435	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
326427002436	active site
326427002437	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
326427002438	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
326427002439	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
326427002440	Ligand Binding Site [chemical binding]; other site
326427002441	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
326427002442	Ligand Binding Site [chemical binding]; other site
326427002443	hypothetical protein; Reviewed; Region: PRK00024
326427002444	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
326427002445	MPN+ (JAMM) motif; other site
326427002446	Zinc-binding site [ion binding]; other site
326427002447	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
326427002448	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
326427002449	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
326427002450	active site
326427002451	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
326427002452	HIT family signature motif; other site
326427002453	catalytic residue [active]
326427002454	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
326427002455	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
326427002456	active site
326427002457	catalytic triad [active]
326427002458	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
326427002459	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
326427002460	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427002461	GAF domain; Region: GAF; pfam01590
326427002462	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
326427002463	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326427002464	metal binding site [ion binding]; metal-binding site
326427002465	active site
326427002466	I-site; other site
326427002467	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
326427002468	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
326427002469	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
326427002470	active site
326427002471	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
326427002472	putative ligand binding site [chemical binding]; other site
326427002473	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
326427002474	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
326427002475	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
326427002476	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326427002477	active site
326427002478	motif I; other site
326427002479	motif II; other site
326427002480	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
326427002481	HlyD family secretion protein; Region: HlyD_3; pfam13437
326427002482	Chain length determinant protein; Region: Wzz; cl15801
326427002483	AAA domain; Region: AAA_31; pfam13614
326427002484	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
326427002485	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
326427002486	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427002487	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427002488	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
326427002489	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
326427002490	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427002491	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326427002492	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
326427002493	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
326427002494	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
326427002495	Probable Catalytic site; other site
326427002496	metal-binding site
326427002497	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
326427002498	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427002499	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427002500	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
326427002501	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
326427002502	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
326427002503	Probable Catalytic site; other site
326427002504	metal-binding site
326427002505	O-Antigen ligase; Region: Wzy_C; pfam04932
326427002506	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
326427002507	Asp-box motif; other site
326427002508	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
326427002509	PQQ-like domain; Region: PQQ_2; pfam13360
326427002510	Trp docking motif [polypeptide binding]; other site
326427002511	active site
326427002512	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
326427002513	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
326427002514	Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979
326427002515	active site
326427002516	Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979
326427002517	active site
326427002518	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
326427002519	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
326427002520	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110
326427002521	Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077
326427002522	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326427002523	classical (c) SDRs; Region: SDR_c; cd05233
326427002524	NAD(P) binding site [chemical binding]; other site
326427002525	active site
326427002526	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
326427002527	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
326427002528	acyl-activating enzyme (AAE) consensus motif; other site
326427002529	active site
326427002530	AMP binding site [chemical binding]; other site
326427002531	CoA binding site [chemical binding]; other site
326427002532	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931
326427002533	putative active site [active]
326427002534	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
326427002535	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
326427002536	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
326427002537	trimer interface [polypeptide binding]; other site
326427002538	active site
326427002539	substrate binding site [chemical binding]; other site
326427002540	CoA binding site [chemical binding]; other site
326427002541	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
326427002542	active site
326427002543	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
326427002544	homodimer interface [polypeptide binding]; other site
326427002545	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
326427002546	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
326427002547	trimer interface [polypeptide binding]; other site
326427002548	active site
326427002549	substrate binding site [chemical binding]; other site
326427002550	CoA binding site [chemical binding]; other site
326427002551	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
326427002552	Ligand binding site; other site
326427002553	Putative Catalytic site; other site
326427002554	DXD motif; other site
326427002555	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
326427002556	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
326427002557	B12 binding site [chemical binding]; other site
326427002558	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326427002559	FeS/SAM binding site; other site
326427002560	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
326427002561	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
326427002562	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427002563	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
326427002564	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
326427002565	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
326427002566	Ligand binding site; other site
326427002567	Putative Catalytic site; other site
326427002568	DXD motif; other site
326427002569	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
326427002570	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
326427002571	dimer interface [polypeptide binding]; other site
326427002572	active site
326427002573	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
326427002574	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
326427002575	inhibitor-cofactor binding pocket; inhibition site
326427002576	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427002577	catalytic residue [active]
326427002578	hypothetical protein; Provisional; Region: PRK07233
326427002579	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
326427002580	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
326427002581	Bacterial sugar transferase; Region: Bac_transf; pfam02397
326427002582	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
326427002583	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
326427002584	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
326427002585	crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155
326427002586	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
326427002587	acyl-activating enzyme (AAE) consensus motif; other site
326427002588	putative AMP binding site [chemical binding]; other site
326427002589	putative active site [active]
326427002590	putative CoA binding site [chemical binding]; other site
326427002591	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
326427002592	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
326427002593	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
326427002594	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
326427002595	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
326427002596	Zn2+ binding site [ion binding]; other site
326427002597	Mg2+ binding site [ion binding]; other site
326427002598	PAS domain S-box; Region: sensory_box; TIGR00229
326427002599	PAS domain S-box; Region: sensory_box; TIGR00229
326427002600	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427002601	putative active site [active]
326427002602	heme pocket [chemical binding]; other site
326427002603	PAS domain; Region: PAS_9; pfam13426
326427002604	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427002605	putative active site [active]
326427002606	heme pocket [chemical binding]; other site
326427002607	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427002608	GAF domain; Region: GAF; pfam01590
326427002609	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326427002610	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427002611	dimer interface [polypeptide binding]; other site
326427002612	phosphorylation site [posttranslational modification]
326427002613	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427002614	ATP binding site [chemical binding]; other site
326427002615	Mg2+ binding site [ion binding]; other site
326427002616	G-X-G motif; other site
326427002617	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427002618	PAS domain; Region: PAS_9; pfam13426
326427002619	putative active site [active]
326427002620	heme pocket [chemical binding]; other site
326427002621	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427002622	PAS domain; Region: PAS_9; pfam13426
326427002623	putative active site [active]
326427002624	heme pocket [chemical binding]; other site
326427002625	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427002626	PAS domain; Region: PAS_9; pfam13426
326427002627	putative active site [active]
326427002628	heme pocket [chemical binding]; other site
326427002629	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
326427002630	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427002631	dimer interface [polypeptide binding]; other site
326427002632	phosphorylation site [posttranslational modification]
326427002633	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427002634	ATP binding site [chemical binding]; other site
326427002635	Mg2+ binding site [ion binding]; other site
326427002636	G-X-G motif; other site
326427002637	Response regulator receiver domain; Region: Response_reg; pfam00072
326427002638	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427002639	active site
326427002640	phosphorylation site [posttranslational modification]
326427002641	intermolecular recognition site; other site
326427002642	dimerization interface [polypeptide binding]; other site
326427002643	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
326427002644	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427002645	active site
326427002646	phosphorylation site [posttranslational modification]
326427002647	intermolecular recognition site; other site
326427002648	dimerization interface [polypeptide binding]; other site
326427002649	Response regulator receiver domain; Region: Response_reg; pfam00072
326427002650	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427002651	active site
326427002652	phosphorylation site [posttranslational modification]
326427002653	intermolecular recognition site; other site
326427002654	dimerization interface [polypeptide binding]; other site
326427002655	Hpt domain; Region: Hpt; pfam01627
326427002656	putative binding surface; other site
326427002657	active site
326427002658	Response regulator receiver domain; Region: Response_reg; pfam00072
326427002659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427002660	active site
326427002661	phosphorylation site [posttranslational modification]
326427002662	intermolecular recognition site; other site
326427002663	dimerization interface [polypeptide binding]; other site
326427002664	Response regulator receiver domain; Region: Response_reg; pfam00072
326427002665	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427002666	active site
326427002667	phosphorylation site [posttranslational modification]
326427002668	intermolecular recognition site; other site
326427002669	dimerization interface [polypeptide binding]; other site
326427002670	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
326427002671	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326427002672	metal binding site [ion binding]; metal-binding site
326427002673	active site
326427002674	I-site; other site
326427002675	Response regulator receiver domain; Region: Response_reg; pfam00072
326427002676	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427002677	active site
326427002678	phosphorylation site [posttranslational modification]
326427002679	intermolecular recognition site; other site
326427002680	dimerization interface [polypeptide binding]; other site
326427002681	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
326427002682	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
326427002683	Transposase IS200 like; Region: Y1_Tnp; pfam01797
326427002684	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
326427002685	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
326427002686	active site
326427002687	metal binding site [ion binding]; metal-binding site
326427002688	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
326427002689	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326427002690	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326427002691	catalytic residue [active]
326427002692	Bacitracin resistance protein BacA; Region: BacA; pfam02673
326427002693	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
326427002694	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
326427002695	active site
326427002696	DNA binding site [nucleotide binding]
326427002697	Int/Topo IB signature motif; other site
326427002698	Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY).  Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980
326427002699	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
326427002700	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
326427002701	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
326427002702	Survival protein SurE; Region: SurE; pfam01975
326427002703	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
326427002704	active site
326427002705	catalytic residues [active]
326427002706	metal binding site [ion binding]; metal-binding site
326427002707	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
326427002708	HD domain; Region: HD_4; pfam13328
326427002709	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
326427002710	short chain dehydrogenase; Provisional; Region: PRK06197
326427002711	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
326427002712	putative NAD(P) binding site [chemical binding]; other site
326427002713	active site
326427002714	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
326427002715	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427002716	putative active site [active]
326427002717	heme pocket [chemical binding]; other site
326427002718	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427002719	dimer interface [polypeptide binding]; other site
326427002720	phosphorylation site [posttranslational modification]
326427002721	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427002722	ATP binding site [chemical binding]; other site
326427002723	Mg2+ binding site [ion binding]; other site
326427002724	G-X-G motif; other site
326427002725	Response regulator receiver domain; Region: Response_reg; pfam00072
326427002726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427002727	active site
326427002728	phosphorylation site [posttranslational modification]
326427002729	intermolecular recognition site; other site
326427002730	dimerization interface [polypeptide binding]; other site
326427002731	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
326427002732	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427002733	active site
326427002734	phosphorylation site [posttranslational modification]
326427002735	intermolecular recognition site; other site
326427002736	dimerization interface [polypeptide binding]; other site
326427002737	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
326427002738	Zn2+ binding site [ion binding]; other site
326427002739	Mg2+ binding site [ion binding]; other site
326427002740	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
326427002741	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
326427002742	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
326427002743	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
326427002744	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
326427002745	putative metal binding site; other site
326427002746	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
326427002747	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427002748	Walker A motif; other site
326427002749	ATP binding site [chemical binding]; other site
326427002750	Walker B motif; other site
326427002751	arginine finger; other site
326427002752	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
326427002753	DNA photolyase; Region: DNA_photolyase; pfam00875
326427002754	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
326427002755	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
326427002756	catalytic motif [active]
326427002757	Catalytic residue [active]
326427002758	Aspartyl protease; Region: Asp_protease_2; pfam13650
326427002759	inhibitor binding site; inhibition site
326427002760	catalytic motif [active]
326427002761	Catalytic residue [active]
326427002762	Active site flap [active]
326427002763	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
326427002764	Uncharacterized conserved protein [Function unknown]; Region: COG3339
326427002765	ASRGL1_like domains, a subfamily of the L-Asparaginase type 2-like enzymes. The wider family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. The proenzymes undergo autoproteolytic cleavage before a threonine to generate alpha...; Region: ASRGL1_like; cd04702
326427002766	catalytic nucleophile [active]
326427002767	Thrombospondin type 3 repeat; Region: TSP_3; pfam02412
326427002768	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
326427002769	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
326427002770	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
326427002771	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
326427002772	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427002773	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427002774	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427002775	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427002776	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
326427002777	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427002778	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
326427002779	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323
326427002780	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
326427002781	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
326427002782	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
326427002783	Walker A/P-loop; other site
326427002784	ATP binding site [chemical binding]; other site
326427002785	Q-loop/lid; other site
326427002786	ABC transporter signature motif; other site
326427002787	Walker B; other site
326427002788	D-loop; other site
326427002789	H-loop/switch region; other site
326427002790	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
326427002791	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
326427002792	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326427002793	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427002794	dimer interface [polypeptide binding]; other site
326427002795	conserved gate region; other site
326427002796	putative PBP binding loops; other site
326427002797	ABC-ATPase subunit interface; other site
326427002798	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
326427002799	MgtE intracellular N domain; Region: MgtE_N; smart00924
326427002800	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
326427002801	Divalent cation transporter; Region: MgtE; pfam01769
326427002802	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
326427002803	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
326427002804	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
326427002805	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
326427002806	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
326427002807	Predicted transcriptional regulators [Transcription]; Region: COG1378
326427002808	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
326427002809	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
326427002810	C-terminal domain interface [polypeptide binding]; other site
326427002811	sugar binding site [chemical binding]; other site
326427002812	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
326427002813	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
326427002814	Anti-sigma-K factor rskA; Region: RskA; pfam10099
326427002815	RNA polymerase sigma factor; Provisional; Region: PRK12519
326427002816	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326427002817	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326427002818	DNA binding residues [nucleotide binding]
326427002819	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
326427002820	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
326427002821	substrate binding pocket [chemical binding]; other site
326427002822	chain length determination region; other site
326427002823	substrate-Mg2+ binding site; other site
326427002824	catalytic residues [active]
326427002825	aspartate-rich region 1; other site
326427002826	active site lid residues [active]
326427002827	aspartate-rich region 2; other site
326427002828	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
326427002829	DNA binding site [nucleotide binding]
326427002830	GxxExxY protein; Region: GxxExxY; TIGR04256
326427002831	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
326427002832	PAS fold; Region: PAS_7; pfam12860
326427002833	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427002834	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
326427002835	classical (c) SDRs; Region: SDR_c; cd05233
326427002836	NAD(P) binding site [chemical binding]; other site
326427002837	active site
326427002838	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
326427002839	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
326427002840	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326427002841	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
326427002842	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326427002843	DNA binding residues [nucleotide binding]
326427002844	4-alpha-glucanotransferase; Provisional; Region: PRK14508
326427002845	Arginase family; Region: Arginase; cd09989
326427002846	active site
326427002847	Mn binding site [ion binding]; other site
326427002848	oligomer interface [polypeptide binding]; other site
326427002849	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
326427002850	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
326427002851	P loop; other site
326427002852	Nucleotide binding site [chemical binding]; other site
326427002853	DTAP/Switch II; other site
326427002854	Switch I; other site
326427002855	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
326427002856	catalytic core [active]
326427002857	NAD-dependent deacetylase; Provisional; Region: PRK00481
326427002858	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
326427002859	NAD+ binding site [chemical binding]; other site
326427002860	substrate binding site [chemical binding]; other site
326427002861	Zn binding site [ion binding]; other site
326427002862	PspC domain; Region: PspC; pfam04024
326427002863	Phosphotransferase enzyme family; Region: APH; pfam01636
326427002864	Fructosamine kinase; Region: Fructosamin_kin; cl17579
326427002865	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
326427002866	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
326427002867	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
326427002868	carboxyltransferase (CT) interaction site; other site
326427002869	biotinylation site [posttranslational modification]; other site
326427002870	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
326427002871	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
326427002872	generic binding surface II; other site
326427002873	generic binding surface I; other site
326427002874	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
326427002875	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
326427002876	homotrimer interaction site [polypeptide binding]; other site
326427002877	putative active site [active]
326427002878	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
326427002879	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
326427002880	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
326427002881	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
326427002882	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
326427002883	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
326427002884	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
326427002885	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
326427002886	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
326427002887	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
326427002888	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
326427002889	Domain of unknown function DUF21; Region: DUF21; pfam01595
326427002890	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
326427002891	Transporter associated domain; Region: CorC_HlyC; smart01091
326427002892	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
326427002893	triosephosphate isomerase; Provisional; Region: PRK14565
326427002894	substrate binding site [chemical binding]; other site
326427002895	dimer interface [polypeptide binding]; other site
326427002896	catalytic triad [active]
326427002897	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709
326427002898	active site
326427002899	putative substrate binding region [chemical binding]; other site
326427002900	hypothetical protein; Provisional; Region: PRK14678
326427002901	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
326427002902	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
326427002903	active site
326427002904	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427002905	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
326427002906	YGGT family; Region: YGGT; pfam02325
326427002907	histidinol dehydrogenase; Region: hisD; TIGR00069
326427002908	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
326427002909	NAD binding site [chemical binding]; other site
326427002910	dimerization interface [polypeptide binding]; other site
326427002911	product binding site; other site
326427002912	substrate binding site [chemical binding]; other site
326427002913	zinc binding site [ion binding]; other site
326427002914	catalytic residues [active]
326427002915	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
326427002916	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
326427002917	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
326427002918	protein binding site [polypeptide binding]; other site
326427002919	Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858
326427002920	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
326427002921	active site lid residues [active]
326427002922	substrate binding pocket [chemical binding]; other site
326427002923	catalytic residues [active]
326427002924	substrate-Mg2+ binding site; other site
326427002925	aspartate-rich region 1; other site
326427002926	aspartate-rich region 2; other site
326427002927	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
326427002928	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
326427002929	DNA binding residues [nucleotide binding]
326427002930	B12 binding domain; Region: B12-binding_2; pfam02607
326427002931	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065
326427002932	B12 binding site [chemical binding]; other site
326427002933	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
326427002934	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
326427002935	NADP-binding site; other site
326427002936	homotetramer interface [polypeptide binding]; other site
326427002937	substrate binding site [chemical binding]; other site
326427002938	homodimer interface [polypeptide binding]; other site
326427002939	active site
326427002940	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
326427002941	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
326427002942	active site
326427002943	Substrate binding site; other site
326427002944	Mg++ binding site; other site
326427002945	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
326427002946	putative trimer interface [polypeptide binding]; other site
326427002947	putative CoA binding site [chemical binding]; other site
326427002948	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
326427002949	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
326427002950	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
326427002951	Ligand Binding Site [chemical binding]; other site
326427002952	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
326427002953	elongation factor G; Reviewed; Region: PRK12740
326427002954	G1 box; other site
326427002955	putative GEF interaction site [polypeptide binding]; other site
326427002956	GTP/Mg2+ binding site [chemical binding]; other site
326427002957	Switch I region; other site
326427002958	G2 box; other site
326427002959	G3 box; other site
326427002960	Switch II region; other site
326427002961	G4 box; other site
326427002962	G5 box; other site
326427002963	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
326427002964	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
326427002965	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
326427002966	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
326427002967	dimerization interface [polypeptide binding]; other site
326427002968	putative DNA binding site [nucleotide binding]; other site
326427002969	putative Zn2+ binding site [ion binding]; other site
326427002970	PGAP1-like protein; Region: PGAP1; pfam07819
326427002971	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
326427002972	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
326427002973	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
326427002974	hypothetical protein; Validated; Region: PRK07411
326427002975	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
326427002976	ATP binding site [chemical binding]; other site
326427002977	substrate interface [chemical binding]; other site
326427002978	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
326427002979	active site residue [active]
326427002980	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
326427002981	MoaE interaction surface [polypeptide binding]; other site
326427002982	MoeB interaction surface [polypeptide binding]; other site
326427002983	thiocarboxylated glycine; other site
326427002984	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
326427002985	MPN+ (JAMM) motif; other site
326427002986	Zinc-binding site [ion binding]; other site
326427002987	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
326427002988	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
326427002989	dimer interface [polypeptide binding]; other site
326427002990	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427002991	catalytic residue [active]
326427002992	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
326427002993	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
326427002994	trimerization site [polypeptide binding]; other site
326427002995	active site
326427002996	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
326427002997	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
326427002998	active site residue [active]
326427002999	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
326427003000	active site residue [active]
326427003001	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
326427003002	[2Fe-2S] cluster binding site [ion binding]; other site
326427003003	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
326427003004	FeS assembly protein SufB; Region: sufB; TIGR01980
326427003005	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
326427003006	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
326427003007	trimerization site [polypeptide binding]; other site
326427003008	active site
326427003009	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
326427003010	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
326427003011	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326427003012	catalytic residue [active]
326427003013	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
326427003014	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
326427003015	FeS assembly protein SufD; Region: sufD; TIGR01981
326427003016	FeS assembly ATPase SufC; Region: sufC; TIGR01978
326427003017	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
326427003018	Walker A/P-loop; other site
326427003019	ATP binding site [chemical binding]; other site
326427003020	Q-loop/lid; other site
326427003021	ABC transporter signature motif; other site
326427003022	Walker B; other site
326427003023	D-loop; other site
326427003024	H-loop/switch region; other site
326427003025	Predicted transcriptional regulator [Transcription]; Region: COG2345
326427003026	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
326427003027	putative Zn2+ binding site [ion binding]; other site
326427003028	putative DNA binding site [nucleotide binding]; other site
326427003029	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
326427003030	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427003031	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
326427003032	Walker A motif; other site
326427003033	ATP binding site [chemical binding]; other site
326427003034	Walker B motif; other site
326427003035	arginine finger; other site
326427003036	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
326427003037	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427003038	TPR repeat; Region: TPR_11; pfam13414
326427003039	TPR motif; other site
326427003040	B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034
326427003041	Methyltransferase domain; Region: Methyltransf_23; pfam13489
326427003042	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427003043	S-adenosylmethionine binding site [chemical binding]; other site
326427003044	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427003045	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427003046	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
326427003047	putative deacylase active site [active]
326427003048	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326427003049	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427003050	dimer interface [polypeptide binding]; other site
326427003051	phosphorylation site [posttranslational modification]
326427003052	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427003053	ATP binding site [chemical binding]; other site
326427003054	Mg2+ binding site [ion binding]; other site
326427003055	G-X-G motif; other site
326427003056	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
326427003057	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
326427003058	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
326427003059	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
326427003060	homodimer interface [polypeptide binding]; other site
326427003061	substrate-cofactor binding pocket; other site
326427003062	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427003063	catalytic residue [active]
326427003064	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
326427003065	putative hydrophobic ligand binding site [chemical binding]; other site
326427003066	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
326427003067	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
326427003068	catalytic loop [active]
326427003069	iron binding site [ion binding]; other site
326427003070	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
326427003071	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
326427003072	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
326427003073	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
326427003074	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
326427003075	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
326427003076	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
326427003077	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
326427003078	active site
326427003079	HIGH motif; other site
326427003080	KMSKS motif; other site
326427003081	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
326427003082	tRNA binding surface [nucleotide binding]; other site
326427003083	anticodon binding site; other site
326427003084	Bacterial SH3 domain; Region: SH3_3; cl17532
326427003085	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
326427003086	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
326427003087	active site
326427003088	catalytic site [active]
326427003089	substrate binding site [chemical binding]; other site
326427003090	WYL domain; Region: WYL; cl14852
326427003091	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
326427003092	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
326427003093	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
326427003094	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326427003095	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
326427003096	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326427003097	DNA binding residues [nucleotide binding]
326427003098	GAF domain; Region: GAF; pfam01590
326427003099	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427003100	GAF domain; Region: GAF; pfam01590
326427003101	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
326427003102	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427003103	dimer interface [polypeptide binding]; other site
326427003104	phosphorylation site [posttranslational modification]
326427003105	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427003106	ATP binding site [chemical binding]; other site
326427003107	Mg2+ binding site [ion binding]; other site
326427003108	G-X-G motif; other site
326427003109	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
326427003110	dimer interface [polypeptide binding]; other site
326427003111	substrate binding site [chemical binding]; other site
326427003112	metal binding site [ion binding]; metal-binding site
326427003113	Rubrerythrin [Energy production and conversion]; Region: COG1592
326427003114	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
326427003115	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
326427003116	iron binding site [ion binding]; other site
326427003117	DinB superfamily; Region: DinB_2; pfam12867
326427003118	rod shape-determining protein MreB; Provisional; Region: PRK13930
326427003119	MreB and similar proteins; Region: MreB_like; cd10225
326427003120	nucleotide binding site [chemical binding]; other site
326427003121	Mg binding site [ion binding]; other site
326427003122	putative protofilament interaction site [polypeptide binding]; other site
326427003123	RodZ interaction site [polypeptide binding]; other site
326427003124	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735
326427003125	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
326427003126	gamma subunit interface [polypeptide binding]; other site
326427003127	epsilon subunit interface [polypeptide binding]; other site
326427003128	LBP interface [polypeptide binding]; other site
326427003129	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
326427003130	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
326427003131	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
326427003132	alpha subunit interaction interface [polypeptide binding]; other site
326427003133	Walker A motif; other site
326427003134	ATP binding site [chemical binding]; other site
326427003135	Walker B motif; other site
326427003136	inhibitor binding site; inhibition site
326427003137	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
326427003138	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
326427003139	core domain interface [polypeptide binding]; other site
326427003140	delta subunit interface [polypeptide binding]; other site
326427003141	epsilon subunit interface [polypeptide binding]; other site
326427003142	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
326427003143	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
326427003144	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
326427003145	beta subunit interaction interface [polypeptide binding]; other site
326427003146	Walker A motif; other site
326427003147	ATP binding site [chemical binding]; other site
326427003148	Walker B motif; other site
326427003149	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
326427003150	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
326427003151	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
326427003152	F0F1 ATP synthase subunit B; Provisional; Region: PRK14473
326427003153	ATP synthase subunit C; Region: ATP-synt_C; cl00466
326427003154	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
326427003155	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
326427003156	Response regulator receiver domain; Region: Response_reg; pfam00072
326427003157	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427003158	active site
326427003159	phosphorylation site [posttranslational modification]
326427003160	intermolecular recognition site; other site
326427003161	dimerization interface [polypeptide binding]; other site
326427003162	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
326427003163	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
326427003164	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
326427003165	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
326427003166	phosphate binding site [ion binding]; other site
326427003167	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
326427003168	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
326427003169	carboxyltransferase (CT) interaction site; other site
326427003170	biotinylation site [posttranslational modification]; other site
326427003171	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
326427003172	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
326427003173	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
326427003174	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
326427003175	PAS domain; Region: PAS_9; pfam13426
326427003176	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427003177	putative active site [active]
326427003178	heme pocket [chemical binding]; other site
326427003179	PAS domain S-box; Region: sensory_box; TIGR00229
326427003180	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427003181	putative active site [active]
326427003182	heme pocket [chemical binding]; other site
326427003183	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427003184	dimer interface [polypeptide binding]; other site
326427003185	phosphorylation site [posttranslational modification]
326427003186	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427003187	ATP binding site [chemical binding]; other site
326427003188	Mg2+ binding site [ion binding]; other site
326427003189	G-X-G motif; other site
326427003190	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427003191	Response regulator receiver domain; Region: Response_reg; pfam00072
326427003192	active site
326427003193	phosphorylation site [posttranslational modification]
326427003194	intermolecular recognition site; other site
326427003195	dimerization interface [polypeptide binding]; other site
326427003196	Response regulator receiver domain; Region: Response_reg; pfam00072
326427003197	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427003198	active site
326427003199	phosphorylation site [posttranslational modification]
326427003200	intermolecular recognition site; other site
326427003201	dimerization interface [polypeptide binding]; other site
326427003202	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326427003203	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
326427003204	metal binding site [ion binding]; metal-binding site
326427003205	active site
326427003206	I-site; other site
326427003207	GTP-binding protein LepA; Provisional; Region: PRK05433
326427003208	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
326427003209	G1 box; other site
326427003210	putative GEF interaction site [polypeptide binding]; other site
326427003211	GTP/Mg2+ binding site [chemical binding]; other site
326427003212	Switch I region; other site
326427003213	G2 box; other site
326427003214	G3 box; other site
326427003215	Switch II region; other site
326427003216	G4 box; other site
326427003217	G5 box; other site
326427003218	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
326427003219	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
326427003220	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
326427003221	SurA N-terminal domain; Region: SurA_N; pfam09312
326427003222	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
326427003223	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
326427003224	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
326427003225	homodimer interface [polypeptide binding]; other site
326427003226	metal binding site [ion binding]; metal-binding site
326427003227	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
326427003228	homodimer interface [polypeptide binding]; other site
326427003229	active site
326427003230	putative chemical substrate binding site [chemical binding]; other site
326427003231	metal binding site [ion binding]; metal-binding site
326427003232	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
326427003233	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
326427003234	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
326427003235	active site
326427003236	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
326427003237	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
326427003238	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
326427003239	EamA-like transporter family; Region: EamA; pfam00892
326427003240	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
326427003241	EamA-like transporter family; Region: EamA; pfam00892
326427003242	multifunctional aminopeptidase A; Provisional; Region: PRK00913
326427003243	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
326427003244	interface (dimer of trimers) [polypeptide binding]; other site
326427003245	Substrate-binding/catalytic site; other site
326427003246	Zn-binding sites [ion binding]; other site
326427003247	homoserine dehydrogenase family protein; Region: PLN02700
326427003248	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
326427003249	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
326427003250	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326427003251	NAD(P) binding site [chemical binding]; other site
326427003252	catalytic residues [active]
326427003253	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
326427003254	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326427003255	FeS/SAM binding site; other site
326427003256	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
326427003257	cyclase homology domain; Region: CHD; cd07302
326427003258	nucleotidyl binding site; other site
326427003259	metal binding site [ion binding]; metal-binding site
326427003260	dimer interface [polypeptide binding]; other site
326427003261	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
326427003262	cyclase homology domain; Region: CHD; cd07302
326427003263	nucleotidyl binding site; other site
326427003264	metal binding site [ion binding]; metal-binding site
326427003265	dimer interface [polypeptide binding]; other site
326427003266	AAA ATPase domain; Region: AAA_16; pfam13191
326427003267	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427003268	TPR motif; other site
326427003269	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427003270	binding surface
326427003271	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427003272	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427003273	binding surface
326427003274	TPR motif; other site
326427003275	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427003276	Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407
326427003277	HEAT repeats; Region: HEAT_2; pfam13646
326427003278	HEAT repeats; Region: HEAT_2; pfam13646
326427003279	HEAT repeats; Region: HEAT_2; pfam13646
326427003280	Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911
326427003281	active site
326427003282	diiron metal binding site [ion binding]; other site
326427003283	classical (c) SDRs; Region: SDR_c; cd05233
326427003284	NAD(P) binding site [chemical binding]; other site
326427003285	active site
326427003286	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
326427003287	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
326427003288	metal binding site [ion binding]; metal-binding site
326427003289	dimer interface [polypeptide binding]; other site
326427003290	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
326427003291	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
326427003292	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427003293	S-adenosylmethionine binding site [chemical binding]; other site
326427003294	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
326427003295	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
326427003296	active site
326427003297	Ap6A binding site [chemical binding]; other site
326427003298	nudix motif; other site
326427003299	metal binding site [ion binding]; metal-binding site
326427003300	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
326427003301	dimer interface [polypeptide binding]; other site
326427003302	substrate binding site [chemical binding]; other site
326427003303	metal binding sites [ion binding]; metal-binding site
326427003304	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
326427003305	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
326427003306	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
326427003307	NAD binding site [chemical binding]; other site
326427003308	homotetramer interface [polypeptide binding]; other site
326427003309	homodimer interface [polypeptide binding]; other site
326427003310	substrate binding site [chemical binding]; other site
326427003311	active site
326427003312	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
326427003313	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
326427003314	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
326427003315	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
326427003316	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
326427003317	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
326427003318	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
326427003319	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
326427003320	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
326427003321	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
326427003322	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
326427003323	4Fe-4S binding domain; Region: Fer4; pfam00037
326427003324	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
326427003325	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
326427003326	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
326427003327	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
326427003328	catalytic loop [active]
326427003329	iron binding site [ion binding]; other site
326427003330	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
326427003331	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
326427003332	molybdopterin cofactor binding site; other site
326427003333	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
326427003334	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
326427003335	SLBB domain; Region: SLBB; pfam10531
326427003336	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
326427003337	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
326427003338	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
326427003339	putative dimer interface [polypeptide binding]; other site
326427003340	[2Fe-2S] cluster binding site [ion binding]; other site
326427003341	NADH dehydrogenase subunit D; Validated; Region: PRK06075
326427003342	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
326427003343	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
326427003344	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
326427003345	NADH dehydrogenase subunit B; Validated; Region: PRK06411
326427003346	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
326427003347	isocitrate dehydrogenase; Validated; Region: PRK07362
326427003348	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
326427003349	FOG: CBS domain [General function prediction only]; Region: COG0517
326427003350	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
326427003351	GxxExxY protein; Region: GxxExxY; TIGR04256
326427003352	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
326427003353	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326427003354	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427003355	homodimer interface [polypeptide binding]; other site
326427003356	catalytic residue [active]
326427003357	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
326427003358	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
326427003359	NAD binding site [chemical binding]; other site
326427003360	ligand binding site [chemical binding]; other site
326427003361	catalytic site [active]
326427003362	elongation factor P; Validated; Region: PRK00529
326427003363	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
326427003364	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
326427003365	RNA binding site [nucleotide binding]; other site
326427003366	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
326427003367	RNA binding site [nucleotide binding]; other site
326427003368	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
326427003369	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
326427003370	ring oligomerisation interface [polypeptide binding]; other site
326427003371	ATP/Mg binding site [chemical binding]; other site
326427003372	stacking interactions; other site
326427003373	hinge regions; other site
326427003374	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
326427003375	oligomerisation interface [polypeptide binding]; other site
326427003376	mobile loop; other site
326427003377	roof hairpin; other site
326427003378	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427003379	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326427003380	putative substrate translocation pore; other site
326427003381	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
326427003382	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326427003383	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326427003384	DNA binding residues [nucleotide binding]
326427003385	CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455
326427003386	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732
326427003387	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439
326427003388	CRISPR-associated protein; Region: TIGR03986
326427003389	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
326427003390	CRISPR-associated protein; Region: TIGR03986
326427003391	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
326427003392	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
326427003393	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
326427003394	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
326427003395	CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558
326427003396	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
326427003397	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817
326427003398	CRISPR-associated protein NE0113 (Cas_NE0113); Region: Cas_NE0113; pfam09623
326427003399	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326427003400	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326427003401	DNA binding residues [nucleotide binding]
326427003402	CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cl09837
326427003403	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
326427003404	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
326427003405	active site
326427003406	catalytic site [active]
326427003407	pfkB family carbohydrate kinase; Region: PfkB; pfam00294
326427003408	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
326427003409	substrate binding site [chemical binding]; other site
326427003410	ATP binding site [chemical binding]; other site
326427003411	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
326427003412	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
326427003413	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427003414	Walker A motif; other site
326427003415	ATP binding site [chemical binding]; other site
326427003416	Walker B motif; other site
326427003417	arginine finger; other site
326427003418	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
326427003419	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
326427003420	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
326427003421	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
326427003422	Walker A/P-loop; other site
326427003423	ATP binding site [chemical binding]; other site
326427003424	Q-loop/lid; other site
326427003425	ABC transporter signature motif; other site
326427003426	Walker B; other site
326427003427	D-loop; other site
326427003428	H-loop/switch region; other site
326427003429	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326427003430	MarR family; Region: MarR; pfam01047
326427003431	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326427003432	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427003433	ATP binding site [chemical binding]; other site
326427003434	Mg2+ binding site [ion binding]; other site
326427003435	G-X-G motif; other site
326427003436	ADP-glucose phosphorylase; Region: PLN02643
326427003437	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
326427003438	nucleotide binding site/active site [active]
326427003439	HIT family signature motif; other site
326427003440	catalytic residue [active]
326427003441	Transcriptional regulators [Transcription]; Region: FadR; COG2186
326427003442	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326427003443	DNA-binding site [nucleotide binding]; DNA binding site
326427003444	FCD domain; Region: FCD; pfam07729
326427003445	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
326427003446	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
326427003447	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
326427003448	AAA-like domain; Region: AAA_10; pfam12846
326427003449	ATP binding site [chemical binding]; other site
326427003450	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
326427003451	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
326427003452	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
326427003453	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427003454	dimer interface [polypeptide binding]; other site
326427003455	phosphorylation site [posttranslational modification]
326427003456	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427003457	ATP binding site [chemical binding]; other site
326427003458	Mg2+ binding site [ion binding]; other site
326427003459	G-X-G motif; other site
326427003460	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326427003461	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427003462	active site
326427003463	phosphorylation site [posttranslational modification]
326427003464	intermolecular recognition site; other site
326427003465	dimerization interface [polypeptide binding]; other site
326427003466	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326427003467	DNA binding site [nucleotide binding]
326427003468	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
326427003469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427003470	putative substrate translocation pore; other site
326427003471	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
326427003472	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
326427003473	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
326427003474	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
326427003475	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
326427003476	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
326427003477	active site
326427003478	metal binding site [ion binding]; metal-binding site
326427003479	Methyltransferase domain; Region: Methyltransf_31; pfam13847
326427003480	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427003481	S-adenosylmethionine binding site [chemical binding]; other site
326427003482	cyanophycin synthetase; Provisional; Region: PRK14016
326427003483	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
326427003484	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
326427003485	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
326427003486	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
326427003487	ornithine cyclodeaminase; Validated; Region: PRK08618
326427003488	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
326427003489	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
326427003490	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
326427003491	RNA binding site [nucleotide binding]; other site
326427003492	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
326427003493	RNA binding site [nucleotide binding]; other site
326427003494	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
326427003495	RNA binding site [nucleotide binding]; other site
326427003496	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
326427003497	RNA binding site [nucleotide binding]; other site
326427003498	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
326427003499	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
326427003500	Low molecular weight phosphatase family; Region: LMWPc; cd00115
326427003501	active site
326427003502	Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091
326427003503	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
326427003504	Queuine tRNA-ribosyltransferase; Region: TGT; pfam01702
326427003505	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
326427003506	AAA ATPase domain; Region: AAA_16; pfam13191
326427003507	Walker A motif; other site
326427003508	ATP binding site [chemical binding]; other site
326427003509	DNA methylase; Region: N6_N4_Mtase; cl17433
326427003510	DNA methylase; Region: N6_N4_Mtase; cl17433
326427003511	Methyltransferase domain; Region: Methyltransf_26; pfam13659
326427003512	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
326427003513	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326427003514	ATP binding site [chemical binding]; other site
326427003515	putative Mg++ binding site [ion binding]; other site
326427003516	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
326427003517	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326427003518	nucleotide binding region [chemical binding]; other site
326427003519	ATP-binding site [chemical binding]; other site
326427003520	PglZ domain; Region: PglZ; pfam08665
326427003521	tyrosine decarboxylase; Region: PLN02880
326427003522	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326427003523	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326427003524	catalytic residue [active]
326427003525	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
326427003526	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
326427003527	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326427003528	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
326427003529	lipoyl synthase; Provisional; Region: PRK05481
326427003530	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
326427003531	FeS/SAM binding site; other site
326427003532	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
326427003533	Sortase family; Region: Sortase; pfam04203
326427003534	active site
326427003535	catalytic site [active]
326427003536	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
326427003537	probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885
326427003538	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
326427003539	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
326427003540	ATP-grasp domain; Region: ATP-grasp_4; cl17255
326427003541	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
326427003542	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
326427003543	carboxyltransferase (CT) interaction site; other site
326427003544	biotinylation site [posttranslational modification]; other site
326427003545	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
326427003546	metal ion-dependent adhesion site (MIDAS); other site
326427003547	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
326427003548	active site
326427003549	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
326427003550	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
326427003551	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
326427003552	active site
326427003553	circadian clock protein KaiC; Reviewed; Region: PRK09302
326427003554	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
326427003555	Walker A motif; other site
326427003556	Walker A motif; other site
326427003557	ATP binding site [chemical binding]; other site
326427003558	Walker B motif; other site
326427003559	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
326427003560	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
326427003561	Walker A motif; other site
326427003562	Walker A motif; other site
326427003563	ATP binding site [chemical binding]; other site
326427003564	Walker B motif; other site
326427003565	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427003566	PAS fold; Region: PAS_3; pfam08447
326427003567	putative active site [active]
326427003568	heme pocket [chemical binding]; other site
326427003569	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427003570	dimer interface [polypeptide binding]; other site
326427003571	phosphorylation site [posttranslational modification]
326427003572	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427003573	ATP binding site [chemical binding]; other site
326427003574	Mg2+ binding site [ion binding]; other site
326427003575	G-X-G motif; other site
326427003576	Response regulator receiver domain; Region: Response_reg; pfam00072
326427003577	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427003578	active site
326427003579	phosphorylation site [posttranslational modification]
326427003580	intermolecular recognition site; other site
326427003581	dimerization interface [polypeptide binding]; other site
326427003582	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
326427003583	homodimer interface [polypeptide binding]; other site
326427003584	catalytic residues [active]
326427003585	NAD binding site [chemical binding]; other site
326427003586	substrate binding pocket [chemical binding]; other site
326427003587	flexible flap; other site
326427003588	hypothetical protein; Provisional; Region: PRK04262
326427003589	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
326427003590	dimer interface [polypeptide binding]; other site
326427003591	active site
326427003592	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
326427003593	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
326427003594	active site
326427003595	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
326427003596	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
326427003597	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
326427003598	DUF35 OB-fold domain; Region: DUF35; pfam01796
326427003599	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
326427003600	active site residue [active]
326427003601	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
326427003602	high affinity sulphate transporter 1; Region: sulP; TIGR00815
326427003603	Sulfate transporter family; Region: Sulfate_transp; pfam00916
326427003604	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
326427003605	Putative phosphatase (DUF442); Region: DUF442; cl17385
326427003606	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
326427003607	active site residue [active]
326427003608	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
326427003609	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
326427003610	CPxP  motif; other site
326427003611	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
326427003612	active site residue [active]
326427003613	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
326427003614	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
326427003615	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
326427003616	putative catalytic residues [active]
326427003617	manganese transport protein MntH; Reviewed; Region: PRK00701
326427003618	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
326427003619	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
326427003620	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
326427003621	transmembrane helices; other site
326427003622	Transcriptional regulator [Transcription]; Region: IclR; COG1414
326427003623	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
326427003624	putative DNA binding site [nucleotide binding]; other site
326427003625	putative Zn2+ binding site [ion binding]; other site
326427003626	Bacterial transcriptional regulator; Region: IclR; pfam01614
326427003627	serine O-acetyltransferase; Region: cysE; TIGR01172
326427003628	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
326427003629	trimer interface [polypeptide binding]; other site
326427003630	active site
326427003631	substrate binding site [chemical binding]; other site
326427003632	CoA binding site [chemical binding]; other site
326427003633	Protein of unknown function (DUF1405); Region: DUF1405; pfam07187
326427003634	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
326427003635	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
326427003636	acyl-activating enzyme (AAE) consensus motif; other site
326427003637	putative AMP binding site [chemical binding]; other site
326427003638	putative active site [active]
326427003639	putative CoA binding site [chemical binding]; other site
326427003640	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
326427003641	UbiA prenyltransferase family; Region: UbiA; pfam01040
326427003642	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326427003643	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
326427003644	substrate binding site [chemical binding]; other site
326427003645	oxyanion hole (OAH) forming residues; other site
326427003646	trimer interface [polypeptide binding]; other site
326427003647	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
326427003648	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
326427003649	dimer interface [polypeptide binding]; other site
326427003650	putative functional site; other site
326427003651	putative MPT binding site; other site
326427003652	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
326427003653	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
326427003654	dimer interface [polypeptide binding]; other site
326427003655	putative functional site; other site
326427003656	putative MPT binding site; other site
326427003657	PBP superfamily domain; Region: PBP_like; pfam12727
326427003658	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
326427003659	MoaE interaction surface [polypeptide binding]; other site
326427003660	MoeB interaction surface [polypeptide binding]; other site
326427003661	thiocarboxylated glycine; other site
326427003662	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
326427003663	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
326427003664	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
326427003665	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
326427003666	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
326427003667	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427003668	Walker A motif; other site
326427003669	ATP binding site [chemical binding]; other site
326427003670	Walker B motif; other site
326427003671	arginine finger; other site
326427003672	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
326427003673	Domain of unknown function (DUF309); Region: DUF309; pfam03745
326427003674	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
326427003675	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427003676	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
326427003677	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
326427003678	active site
326427003679	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
326427003680	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
326427003681	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
326427003682	FeoA domain; Region: FeoA; pfam04023
326427003683	enoyl-CoA hydratase; Provisional; Region: PRK05862
326427003684	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326427003685	substrate binding site [chemical binding]; other site
326427003686	oxyanion hole (OAH) forming residues; other site
326427003687	trimer interface [polypeptide binding]; other site
326427003688	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
326427003689	PAS domain S-box; Region: sensory_box; TIGR00229
326427003690	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427003691	putative active site [active]
326427003692	heme pocket [chemical binding]; other site
326427003693	PAS domain; Region: PAS; smart00091
326427003694	PAS fold; Region: PAS_4; pfam08448
326427003695	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326427003696	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427003697	ATP binding site [chemical binding]; other site
326427003698	Mg2+ binding site [ion binding]; other site
326427003699	G-X-G motif; other site
326427003700	Response regulator receiver domain; Region: Response_reg; pfam00072
326427003701	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427003702	active site
326427003703	phosphorylation site [posttranslational modification]
326427003704	intermolecular recognition site; other site
326427003705	dimerization interface [polypeptide binding]; other site
326427003706	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427003707	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326427003708	putative substrate translocation pore; other site
326427003709	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427003710	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
326427003711	putative ADP-binding pocket [chemical binding]; other site
326427003712	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
326427003713	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
326427003714	Chain length determinant protein; Region: Wzz; cl15801
326427003715	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
326427003716	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
326427003717	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326427003718	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427003719	active site
326427003720	phosphorylation site [posttranslational modification]
326427003721	intermolecular recognition site; other site
326427003722	dimerization interface [polypeptide binding]; other site
326427003723	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326427003724	DNA binding site [nucleotide binding]
326427003725	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326427003726	dimerization interface [polypeptide binding]; other site
326427003727	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427003728	dimer interface [polypeptide binding]; other site
326427003729	phosphorylation site [posttranslational modification]
326427003730	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427003731	ATP binding site [chemical binding]; other site
326427003732	Mg2+ binding site [ion binding]; other site
326427003733	G-X-G motif; other site
326427003734	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
326427003735	CRISPR-associated negative auto-regulator DevR/Csa2; Region: DevR; pfam01905
326427003736	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
326427003737	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
326427003738	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
326427003739	Predicted transcriptional regulator [Transcription]; Region: COG2378
326427003740	WYL domain; Region: WYL; pfam13280
326427003741	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
326427003742	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
326427003743	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
326427003744	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
326427003745	rod shape-determining protein MreC; Provisional; Region: PRK13922
326427003746	rod shape-determining protein MreC; Region: MreC; pfam04085
326427003747	rod shape-determining protein MreB; Provisional; Region: PRK13927
326427003748	MreB and similar proteins; Region: MreB_like; cd10225
326427003749	nucleotide binding site [chemical binding]; other site
326427003750	Mg binding site [ion binding]; other site
326427003751	putative protofilament interaction site [polypeptide binding]; other site
326427003752	RodZ interaction site [polypeptide binding]; other site
326427003753	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
326427003754	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
326427003755	Protein of unknown function (DUF444); Region: DUF444; cl17371
326427003756	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
326427003757	metal ion-dependent adhesion site (MIDAS); other site
326427003758	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
326427003759	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
326427003760	RNA binding site [nucleotide binding]; other site
326427003761	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
326427003762	RNA binding site [nucleotide binding]; other site
326427003763	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
326427003764	RNA binding site [nucleotide binding]; other site
326427003765	Ribonuclease P; Region: Ribonuclease_P; pfam00825
326427003766	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
326427003767	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
326427003768	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
326427003769	G-X-X-G motif; other site
326427003770	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
326427003771	RxxxH motif; other site
326427003772	Transposase IS200 like; Region: Y1_Tnp; pfam01797
326427003773	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
326427003774	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
326427003775	Probable transposase; Region: OrfB_IS605; pfam01385
326427003776	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
326427003777	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
326427003778	substrate binding site [chemical binding]; other site
326427003779	ATP binding site [chemical binding]; other site
326427003780	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
326427003781	Amino acid permease; Region: AA_permease_2; pfam13520
326427003782	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
326427003783	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
326427003784	Walker A/P-loop; other site
326427003785	ATP binding site [chemical binding]; other site
326427003786	Q-loop/lid; other site
326427003787	ABC transporter signature motif; other site
326427003788	Walker B; other site
326427003789	D-loop; other site
326427003790	H-loop/switch region; other site
326427003791	ABC-2 type transporter; Region: ABC2_membrane; cl17235
326427003792	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
326427003793	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326427003794	non-specific DNA binding site [nucleotide binding]; other site
326427003795	salt bridge; other site
326427003796	sequence-specific DNA binding site [nucleotide binding]; other site
326427003797	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
326427003798	Peptidase family M23; Region: Peptidase_M23; pfam01551
326427003799	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
326427003800	hydrophobic ligand binding site; other site
326427003801	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
326427003802	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
326427003803	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326427003804	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
326427003805	UbiA prenyltransferase family; Region: UbiA; pfam01040
326427003806	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
326427003807	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
326427003808	O-methyltransferase; Region: Methyltransf_2; pfam00891
326427003809	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326427003810	PGAP1-like protein; Region: PGAP1; pfam07819
326427003811	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326427003812	PGAP1-like protein; Region: PGAP1; pfam07819
326427003813	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
326427003814	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
326427003815	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
326427003816	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
326427003817	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
326427003818	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
326427003819	DTAP/Switch II; other site
326427003820	Switch I; other site
326427003821	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
326427003822	Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043
326427003823	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
326427003824	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
326427003825	P loop; other site
326427003826	Nucleotide binding site [chemical binding]; other site
326427003827	DTAP/Switch II; other site
326427003828	Switch I; other site
326427003829	Domain of unknown function (DUF4380); Region: DUF4380; pfam14315
326427003830	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
326427003831	apolar tunnel; other site
326427003832	heme binding site [chemical binding]; other site
326427003833	dimerization interface [polypeptide binding]; other site
326427003834	hydrolase, alpha/beta fold family protein; Region: PLN02824
326427003835	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
326427003836	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
326427003837	YacP-like NYN domain; Region: NYN_YacP; cl01491
326427003838	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427003839	S-adenosylmethionine binding site [chemical binding]; other site
326427003840	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
326427003841	homooctamer interface [polypeptide binding]; other site
326427003842	active site
326427003843	RibD C-terminal domain; Region: RibD_C; cl17279
326427003844	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
326427003845	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
326427003846	Alcohol dehydrogenase GroES-like domain; Region: ADH_N; pfam08240
326427003847	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
326427003848	putative NAD(P) binding site [chemical binding]; other site
326427003849	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
326427003850	active site
326427003851	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
326427003852	active site
326427003853	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326427003854	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427003855	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
326427003856	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
326427003857	PYR/PP interface [polypeptide binding]; other site
326427003858	dimer interface [polypeptide binding]; other site
326427003859	TPP binding site [chemical binding]; other site
326427003860	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
326427003861	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
326427003862	TPP-binding site [chemical binding]; other site
326427003863	dimer interface [polypeptide binding]; other site
326427003864	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
326427003865	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
326427003866	putative valine binding site [chemical binding]; other site
326427003867	dimer interface [polypeptide binding]; other site
326427003868	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
326427003869	ketol-acid reductoisomerase; Provisional; Region: PRK05479
326427003870	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
326427003871	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
326427003872	2-isopropylmalate synthase; Validated; Region: PRK00915
326427003873	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
326427003874	active site
326427003875	catalytic residues [active]
326427003876	metal binding site [ion binding]; metal-binding site
326427003877	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
326427003878	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
326427003879	Prephenate dehydratase; Region: PDT; pfam00800
326427003880	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
326427003881	putative L-Phe binding site [chemical binding]; other site
326427003882	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
326427003883	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
326427003884	substrate binding site [chemical binding]; other site
326427003885	ligand binding site [chemical binding]; other site
326427003886	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
326427003887	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
326427003888	substrate binding site [chemical binding]; other site
326427003889	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
326427003890	Peptidase family M23; Region: Peptidase_M23; pfam01551
326427003891	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
326427003892	intermolecular salt bridges; other site
326427003893	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
326427003894	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
326427003895	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
326427003896	Aerotolerance regulator N-terminal; Region: BatA; cl06567
326427003897	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
326427003898	metal ion-dependent adhesion site (MIDAS); other site
326427003899	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
326427003900	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
326427003901	metal ion-dependent adhesion site (MIDAS); other site
326427003902	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
326427003903	GAF domain; Region: GAF_3; pfam13492
326427003904	GAF domain; Region: GAF_2; pfam13185
326427003905	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427003906	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427003907	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427003908	GAF domain; Region: GAF; pfam01590
326427003909	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427003910	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427003911	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427003912	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427003913	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427003914	GAF domain; Region: GAF; pfam01590
326427003915	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
326427003916	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
326427003917	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
326427003918	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
326427003919	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
326427003920	Cytochrome P450; Region: p450; cl12078
326427003921	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
326427003922	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
326427003923	classical (c) SDRs; Region: SDR_c; cd05233
326427003924	NAD(P) binding site [chemical binding]; other site
326427003925	active site
326427003926	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427003927	NAD(P) binding site [chemical binding]; other site
326427003928	active site
326427003929	acetoin reductase; Validated; Region: PRK08643
326427003930	classical (c) SDRs; Region: SDR_c; cd05233
326427003931	NAD(P) binding site [chemical binding]; other site
326427003932	active site
326427003933	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
326427003934	Tetratricopeptide repeat; Region: TPR_16; pfam13432
326427003935	binding surface
326427003936	TPR motif; other site
326427003937	cobyric acid synthase; Provisional; Region: PRK00784
326427003938	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
326427003939	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
326427003940	catalytic triad [active]
326427003941	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
326427003942	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326427003943	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427003944	homodimer interface [polypeptide binding]; other site
326427003945	catalytic residue [active]
326427003946	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
326427003947	homotrimer interface [polypeptide binding]; other site
326427003948	Walker A motif; other site
326427003949	GTP binding site [chemical binding]; other site
326427003950	Walker B motif; other site
326427003951	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
326427003952	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
326427003953	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
326427003954	catalytic triad [active]
326427003955	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
326427003956	active site
326427003957	SAM binding site [chemical binding]; other site
326427003958	homodimer interface [polypeptide binding]; other site
326427003959	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
326427003960	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
326427003961	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
326427003962	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
326427003963	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
326427003964	active site
326427003965	SAM binding site [chemical binding]; other site
326427003966	homodimer interface [polypeptide binding]; other site
326427003967	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
326427003968	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
326427003969	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
326427003970	active site
326427003971	SAM binding site [chemical binding]; other site
326427003972	homodimer interface [polypeptide binding]; other site
326427003973	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
326427003974	active site
326427003975	SAM binding site [chemical binding]; other site
326427003976	homodimer interface [polypeptide binding]; other site
326427003977	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
326427003978	active site
326427003979	putative homodimer interface [polypeptide binding]; other site
326427003980	SAM binding site [chemical binding]; other site
326427003981	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
326427003982	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427003983	S-adenosylmethionine binding site [chemical binding]; other site
326427003984	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
326427003985	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
326427003986	Precorrin-8X methylmutase; Region: CbiC; pfam02570
326427003987	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
326427003988	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
326427003989	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
326427003990	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
326427003991	putative active site [active]
326427003992	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
326427003993	putative active site [active]
326427003994	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
326427003995	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
326427003996	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
326427003997	Walker A/P-loop; other site
326427003998	ATP binding site [chemical binding]; other site
326427003999	Q-loop/lid; other site
326427004000	ABC transporter signature motif; other site
326427004001	Walker B; other site
326427004002	D-loop; other site
326427004003	H-loop/switch region; other site
326427004004	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
326427004005	cobalt transport protein CbiN; Provisional; Region: PRK02898
326427004006	cobalt transport protein CbiM; Validated; Region: PRK08319
326427004007	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
326427004008	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
326427004009	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
326427004010	putative dimer interface [polypeptide binding]; other site
326427004011	active site pocket [active]
326427004012	putative cataytic base [active]
326427004013	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
326427004014	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
326427004015	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
326427004016	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
326427004017	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
326427004018	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
326427004019	homodimer interface [polypeptide binding]; other site
326427004020	Walker A motif; other site
326427004021	ATP binding site [chemical binding]; other site
326427004022	hydroxycobalamin binding site [chemical binding]; other site
326427004023	Walker B motif; other site
326427004024	threonine dehydratase; Reviewed; Region: PRK09224
326427004025	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
326427004026	tetramer interface [polypeptide binding]; other site
326427004027	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427004028	catalytic residue [active]
326427004029	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
326427004030	putative Ile/Val binding site [chemical binding]; other site
326427004031	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
326427004032	putative Ile/Val binding site [chemical binding]; other site
326427004033	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427004034	GAF domain; Region: GAF; pfam01590
326427004035	GAF domain; Region: GAF; pfam01590
326427004036	GAF domain; Region: GAF_2; pfam13185
326427004037	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
326427004038	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326427004039	metal binding site [ion binding]; metal-binding site
326427004040	active site
326427004041	I-site; other site
326427004042	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
326427004043	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
326427004044	tetramer interface [polypeptide binding]; other site
326427004045	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427004046	catalytic residue [active]
326427004047	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
326427004048	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427004049	S-adenosylmethionine binding site [chemical binding]; other site
326427004050	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
326427004051	magnesium-protoporphyrin IX monomethyl ester cyclase; Provisional; Region: PRK13654
326427004052	dinuclear metal binding motif [ion binding]; other site
326427004053	magnesium chelatase subunit H; Provisional; Region: PRK12493
326427004054	Domain of unknown function (DUF3479); Region: DUF3479; pfam11965
326427004055	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
326427004056	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
326427004057	PUCC protein; Region: PUCC; pfam03209
326427004058	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
326427004059	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
326427004060	tRNA; other site
326427004061	putative tRNA binding site [nucleotide binding]; other site
326427004062	putative NADP binding site [chemical binding]; other site
326427004063	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
326427004064	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
326427004065	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
326427004066	domain interfaces; other site
326427004067	active site
326427004068	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
326427004069	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
326427004070	active site
326427004071	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
326427004072	dimer interface [polypeptide binding]; other site
326427004073	active site
326427004074	Schiff base residues; other site
326427004075	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
326427004076	substrate binding site [chemical binding]; other site
326427004077	active site
326427004078	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
326427004079	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
326427004080	inhibitor-cofactor binding pocket; inhibition site
326427004081	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427004082	catalytic residue [active]
326427004083	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
326427004084	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
326427004085	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
326427004086	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
326427004087	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
326427004088	catalytic loop [active]
326427004089	iron binding site [ion binding]; other site
326427004090	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
326427004091	putative acyl-acceptor binding pocket; other site
326427004092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427004093	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326427004094	putative substrate translocation pore; other site
326427004095	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
326427004096	dimerization interface [polypeptide binding]; other site
326427004097	active site
326427004098	LabA_like proteins; Region: LabA_like; cd06167
326427004099	putative metal binding site [ion binding]; other site
326427004100	Uncharacterized conserved protein [Function unknown]; Region: COG1432
326427004101	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
326427004102	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
326427004103	Metal-binding active site; metal-binding site
326427004104	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427004105	NAD(P) binding site [chemical binding]; other site
326427004106	active site
326427004107	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
326427004108	active site
326427004109	catalytic residues [active]
326427004110	metal binding site [ion binding]; metal-binding site
326427004111	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
326427004112	hypothetical protein; Reviewed; Region: PRK09588
326427004113	Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324
326427004114	trehalose synthase; Region: treS_nterm; TIGR02456
326427004115	active site
326427004116	catalytic site [active]
326427004117	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326427004118	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
326427004119	NMT1/THI5 like; Region: NMT1; pfam09084
326427004120	oligoendopeptidase F; Region: pepF; TIGR00181
326427004121	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
326427004122	active site
326427004123	Zn binding site [ion binding]; other site
326427004124	AAA-like domain; Region: AAA_10; pfam12846
326427004125	Tubulin like; Region: Tubulin_2; pfam13809
326427004126	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
326427004127	metal ion-dependent adhesion site (MIDAS); other site
326427004128	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326427004129	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427004130	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326427004131	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
326427004132	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
326427004133	active site
326427004134	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
326427004135	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
326427004136	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326427004137	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
326427004138	Transglycosylase; Region: Transgly; pfam00912
326427004139	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
326427004140	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
326427004141	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
326427004142	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
326427004143	putative active site [active]
326427004144	putative catalytic site [active]
326427004145	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
326427004146	putative active site [active]
326427004147	putative catalytic site [active]
326427004148	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
326427004149	mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253
326427004150	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326427004151	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326427004152	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326427004153	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326427004154	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326427004155	Uncharacterized conserved protein [Function unknown]; Region: COG3777
326427004156	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
326427004157	active site 2 [active]
326427004158	active site 1 [active]
326427004159	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
326427004160	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
326427004161	Cysteine-rich domain; Region: CCG; pfam02754
326427004162	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
326427004163	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
326427004164	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
326427004165	putative molybdopterin cofactor binding site [chemical binding]; other site
326427004166	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
326427004167	putative molybdopterin cofactor binding site; other site
326427004168	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
326427004169	hypothetical protein; Provisional; Region: PRK06541
326427004170	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
326427004171	inhibitor-cofactor binding pocket; inhibition site
326427004172	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427004173	catalytic residue [active]
326427004174	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427004175	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
326427004176	Coenzyme A binding pocket [chemical binding]; other site
326427004177	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
326427004178	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427004179	S-adenosylmethionine binding site [chemical binding]; other site
326427004180	MarR family; Region: MarR; pfam01047
326427004181	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326427004182	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
326427004183	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
326427004184	Competence protein; Region: Competence; pfam03772
326427004185	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
326427004186	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
326427004187	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326427004188	Histidine kinase; Region: HisKA_3; pfam07730
326427004189	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427004190	ATP binding site [chemical binding]; other site
326427004191	Mg2+ binding site [ion binding]; other site
326427004192	G-X-G motif; other site
326427004193	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326427004194	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427004195	active site
326427004196	phosphorylation site [posttranslational modification]
326427004197	intermolecular recognition site; other site
326427004198	dimerization interface [polypeptide binding]; other site
326427004199	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326427004200	DNA binding residues [nucleotide binding]
326427004201	dimerization interface [polypeptide binding]; other site
326427004202	DNA topoisomerase I; Validated; Region: PRK06599
326427004203	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
326427004204	active site
326427004205	interdomain interaction site; other site
326427004206	putative metal-binding site [ion binding]; other site
326427004207	nucleotide binding site [chemical binding]; other site
326427004208	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
326427004209	domain I; other site
326427004210	DNA binding groove [nucleotide binding]
326427004211	phosphate binding site [ion binding]; other site
326427004212	domain II; other site
326427004213	domain III; other site
326427004214	nucleotide binding site [chemical binding]; other site
326427004215	catalytic site [active]
326427004216	domain IV; other site
326427004217	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
326427004218	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
326427004219	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
326427004220	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
326427004221	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
326427004222	heterodimer interface [polypeptide binding]; other site
326427004223	substrate interaction site [chemical binding]; other site
326427004224	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
326427004225	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
326427004226	active site
326427004227	substrate binding site [chemical binding]; other site
326427004228	coenzyme B12 binding site [chemical binding]; other site
326427004229	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
326427004230	B12 binding site [chemical binding]; other site
326427004231	cobalt ligand [ion binding]; other site
326427004232	membrane ATPase/protein kinase; Provisional; Region: PRK09435
326427004233	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
326427004234	GTP/Mg2+ binding site [chemical binding]; other site
326427004235	G5 box; other site
326427004236	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
326427004237	Walker A; other site
326427004238	G1 box; other site
326427004239	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
326427004240	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326427004241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427004242	active site
326427004243	phosphorylation site [posttranslational modification]
326427004244	intermolecular recognition site; other site
326427004245	dimerization interface [polypeptide binding]; other site
326427004246	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326427004247	DNA binding site [nucleotide binding]
326427004248	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
326427004249	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427004250	Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828
326427004251	S-adenosylmethionine binding site [chemical binding]; other site
326427004252	HNH endonuclease; Region: HNH_2; pfam13391
326427004253	FOG: WD40 repeat [General function prediction only]; Region: COG2319
326427004254	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326427004255	structural tetrad; other site
326427004256	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
326427004257	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
326427004258	GTP binding site; other site
326427004259	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
326427004260	transcription termination factor Rho; Provisional; Region: PRK12608
326427004261	RNA binding site [nucleotide binding]; other site
326427004262	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
326427004263	multimer interface [polypeptide binding]; other site
326427004264	Walker A motif; other site
326427004265	ATP binding site [chemical binding]; other site
326427004266	Walker B motif; other site
326427004267	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
326427004268	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
326427004269	alphaNTD - beta interaction site [polypeptide binding]; other site
326427004270	alphaNTD homodimer interface [polypeptide binding]; other site
326427004271	alphaNTD - beta' interaction site [polypeptide binding]; other site
326427004272	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
326427004273	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
326427004274	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
326427004275	catalytic residues [active]
326427004276	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
326427004277	Response regulator receiver domain; Region: Response_reg; pfam00072
326427004278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427004279	active site
326427004280	phosphorylation site [posttranslational modification]
326427004281	intermolecular recognition site; other site
326427004282	dimerization interface [polypeptide binding]; other site
326427004283	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427004284	PAS domain; Region: PAS_9; pfam13426
326427004285	putative active site [active]
326427004286	heme pocket [chemical binding]; other site
326427004287	GAF domain; Region: GAF; cl17456
326427004288	circadian clock protein KaiC; Reviewed; Region: PRK09302
326427004289	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
326427004290	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
326427004291	Walker A motif; other site
326427004292	Walker A motif; other site
326427004293	ATP binding site [chemical binding]; other site
326427004294	Walker B motif; other site
326427004295	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
326427004296	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
326427004297	Walker A motif; other site
326427004298	Walker A/P-loop; other site
326427004299	ATP binding site [chemical binding]; other site
326427004300	ATP binding site [chemical binding]; other site
326427004301	Walker B motif; other site
326427004302	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
326427004303	tetramer interface [polypeptide binding]; other site
326427004304	dimer interface [polypeptide binding]; other site
326427004305	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
326427004306	tetramer interface [polypeptide binding]; other site
326427004307	dimer interface [polypeptide binding]; other site
326427004308	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427004309	PAS domain; Region: PAS_9; pfam13426
326427004310	putative active site [active]
326427004311	heme pocket [chemical binding]; other site
326427004312	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
326427004313	Histidine kinase; Region: HisKA_2; pfam07568
326427004314	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427004315	ATP binding site [chemical binding]; other site
326427004316	Mg2+ binding site [ion binding]; other site
326427004317	G-X-G motif; other site
326427004318	haloacid dehalogenase superfamily protein; Provisional; Region: PRK14562
326427004319	Translin family; Region: Translin; cl00957
326427004320	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
326427004321	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326427004322	metal binding site [ion binding]; metal-binding site
326427004323	active site
326427004324	I-site; other site
326427004325	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
326427004326	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
326427004327	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
326427004328	Walker A/P-loop; other site
326427004329	ATP binding site [chemical binding]; other site
326427004330	Q-loop/lid; other site
326427004331	ABC transporter signature motif; other site
326427004332	Walker B; other site
326427004333	D-loop; other site
326427004334	H-loop/switch region; other site
326427004335	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
326427004336	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427004337	dimer interface [polypeptide binding]; other site
326427004338	ABC-ATPase subunit interface; other site
326427004339	putative PBP binding loops; other site
326427004340	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
326427004341	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
326427004342	Predicted transcriptional regulators [Transcription]; Region: COG1695
326427004343	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
326427004344	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
326427004345	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
326427004346	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
326427004347	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
326427004348	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
326427004349	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326427004350	sequence-specific DNA binding site [nucleotide binding]; other site
326427004351	salt bridge; other site
326427004352	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326427004353	non-specific DNA binding site [nucleotide binding]; other site
326427004354	salt bridge; other site
326427004355	sequence-specific DNA binding site [nucleotide binding]; other site
326427004356	Domain of unknown function DUF87; Region: DUF87; pfam01935
326427004357	AAA-like domain; Region: AAA_10; pfam12846
326427004358	Zonular occludens toxin (Zot); Region: Zot; cl17485
326427004359	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
326427004360	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
326427004361	minor groove reading motif; other site
326427004362	helix-hairpin-helix signature motif; other site
326427004363	substrate binding pocket [chemical binding]; other site
326427004364	active site
326427004365	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
326427004366	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
326427004367	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
326427004368	cofactor binding site; other site
326427004369	DNA binding site [nucleotide binding]
326427004370	substrate interaction site [chemical binding]; other site
326427004371	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
326427004372	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
326427004373	Methyltransferase domain; Region: Methyltransf_26; pfam13659
326427004374	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427004375	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
326427004376	putative acetyltransferase; Provisional; Region: PRK03624
326427004377	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427004378	Coenzyme A binding pocket [chemical binding]; other site
326427004379	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
326427004380	active site
326427004381	catalytic residues [active]
326427004382	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
326427004383	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
326427004384	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
326427004385	ATP-binding site [chemical binding]; other site
326427004386	Sugar specificity; other site
326427004387	Pyrimidine base specificity; other site
326427004388	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
326427004389	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
326427004390	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
326427004391	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
326427004392	NAD(P) binding site [chemical binding]; other site
326427004393	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
326427004394	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
326427004395	oligomer interface [polypeptide binding]; other site
326427004396	active site
326427004397	metal binding site [ion binding]; metal-binding site
326427004398	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
326427004399	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
326427004400	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
326427004401	active site
326427004402	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
326427004403	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
326427004404	active site
326427004405	Zn binding site [ion binding]; other site
326427004406	hypothetical protein; Provisional; Region: PRK08912
326427004407	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326427004408	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427004409	homodimer interface [polypeptide binding]; other site
326427004410	catalytic residue [active]
326427004411	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
326427004412	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
326427004413	putative MPT binding site; other site
326427004414	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427004415	TPR motif; other site
326427004416	TPR repeat; Region: TPR_11; pfam13414
326427004417	binding surface
326427004418	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427004419	binding surface
326427004420	TPR motif; other site
326427004421	TPR repeat; Region: TPR_11; pfam13414
326427004422	TPR repeat; Region: TPR_11; pfam13414
326427004423	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427004424	binding surface
326427004425	TPR motif; other site
326427004426	TPR repeat; Region: TPR_11; pfam13414
326427004427	TPR repeat; Region: TPR_11; pfam13414
326427004428	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427004429	TPR repeat; Region: TPR_11; pfam13414
326427004430	TPR motif; other site
326427004431	binding surface
326427004432	TPR repeat; Region: TPR_11; pfam13414
326427004433	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427004434	binding surface
326427004435	TPR motif; other site
326427004436	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427004437	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427004438	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
326427004439	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
326427004440	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
326427004441	putative substrate binding pocket [chemical binding]; other site
326427004442	dimer interface [polypeptide binding]; other site
326427004443	phosphate binding site [ion binding]; other site
326427004444	Domain of unknown function (DUF897); Region: DUF897; cl01312
326427004445	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
326427004446	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427004447	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
326427004448	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
326427004449	minor groove reading motif; other site
326427004450	helix-hairpin-helix signature motif; other site
326427004451	substrate binding pocket [chemical binding]; other site
326427004452	active site
326427004453	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
326427004454	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
326427004455	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
326427004456	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
326427004457	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
326427004458	peptide binding site [polypeptide binding]; other site
326427004459	dimer interface [polypeptide binding]; other site
326427004460	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
326427004461	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427004462	dimer interface [polypeptide binding]; other site
326427004463	conserved gate region; other site
326427004464	putative PBP binding loops; other site
326427004465	ABC-ATPase subunit interface; other site
326427004466	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
326427004467	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427004468	dimer interface [polypeptide binding]; other site
326427004469	conserved gate region; other site
326427004470	putative PBP binding loops; other site
326427004471	ABC-ATPase subunit interface; other site
326427004472	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
326427004473	PLD-like domain; Region: PLDc_2; pfam13091
326427004474	putative active site [active]
326427004475	catalytic site [active]
326427004476	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
326427004477	PLD-like domain; Region: PLDc_2; pfam13091
326427004478	putative active site [active]
326427004479	catalytic site [active]
326427004480	Nuclease-related domain; Region: NERD; pfam08378
326427004481	excinuclease ABC subunit B; Provisional; Region: PRK05298
326427004482	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326427004483	ATP binding site [chemical binding]; other site
326427004484	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326427004485	nucleotide binding region [chemical binding]; other site
326427004486	ATP-binding site [chemical binding]; other site
326427004487	Ultra-violet resistance protein B; Region: UvrB; pfam12344
326427004488	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
326427004489	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
326427004490	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
326427004491	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
326427004492	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
326427004493	active site
326427004494	putative substrate binding pocket [chemical binding]; other site
326427004495	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
326427004496	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
326427004497	CoA-binding site [chemical binding]; other site
326427004498	ATP-binding [chemical binding]; other site
326427004499	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
326427004500	Transglycosylase; Region: Transgly; pfam00912
326427004501	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
326427004502	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
326427004503	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326427004504	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
326427004505	nucleophilic elbow; other site
326427004506	catalytic triad; other site
326427004507	seryl-tRNA synthetase; Provisional; Region: PRK05431
326427004508	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
326427004509	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
326427004510	dimer interface [polypeptide binding]; other site
326427004511	active site
326427004512	motif 1; other site
326427004513	motif 2; other site
326427004514	motif 3; other site
326427004515	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
326427004516	putative active site [active]
326427004517	nucleotide binding site [chemical binding]; other site
326427004518	nudix motif; other site
326427004519	putative metal binding site [ion binding]; other site
326427004520	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
326427004521	nudix motif; other site
326427004522	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
326427004523	Predicted membrane protein [Function unknown]; Region: COG1470
326427004524	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
326427004525	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
326427004526	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
326427004527	Walker A/P-loop; other site
326427004528	ATP binding site [chemical binding]; other site
326427004529	Q-loop/lid; other site
326427004530	ABC transporter signature motif; other site
326427004531	Walker B; other site
326427004532	D-loop; other site
326427004533	H-loop/switch region; other site
326427004534	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
326427004535	camphor resistance protein CrcB; Provisional; Region: PRK14215
326427004536	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
326427004537	FOG: CBS domain [General function prediction only]; Region: COG0517
326427004538	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
326427004539	FOG: CBS domain [General function prediction only]; Region: COG0517
326427004540	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
326427004541	FOG: CBS domain [General function prediction only]; Region: COG0517
326427004542	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
326427004543	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
326427004544	Clp amino terminal domain; Region: Clp_N; pfam02861
326427004545	Clp amino terminal domain; Region: Clp_N; pfam02861
326427004546	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427004547	Walker A motif; other site
326427004548	ATP binding site [chemical binding]; other site
326427004549	Walker B motif; other site
326427004550	arginine finger; other site
326427004551	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427004552	Walker A motif; other site
326427004553	ATP binding site [chemical binding]; other site
326427004554	Walker B motif; other site
326427004555	arginine finger; other site
326427004556	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
326427004557	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
326427004558	RNA binding site [nucleotide binding]; other site
326427004559	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
326427004560	RNA binding site [nucleotide binding]; other site
326427004561	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
326427004562	RNA binding site [nucleotide binding]; other site
326427004563	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
326427004564	RNA binding site [nucleotide binding]; other site
326427004565	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
326427004566	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
326427004567	active site residue [active]
326427004568	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
326427004569	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
326427004570	active site
326427004571	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
326427004572	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
326427004573	nudix motif; other site
326427004574	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
326427004575	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
326427004576	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
326427004577	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
326427004578	FMN binding site [chemical binding]; other site
326427004579	substrate binding site [chemical binding]; other site
326427004580	putative catalytic residue [active]
326427004581	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
326427004582	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
326427004583	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
326427004584	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
326427004585	Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440
326427004586	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
326427004587	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
326427004588	active site
326427004589	Int/Topo IB signature motif; other site
326427004590	glycyl-tRNA synthetase; Provisional; Region: PRK14894
326427004591	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
326427004592	dimer interface [polypeptide binding]; other site
326427004593	motif 1; other site
326427004594	active site
326427004595	motif 2; other site
326427004596	motif 3; other site
326427004597	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
326427004598	anticodon binding site; other site
326427004599	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
326427004600	Moco binding site; other site
326427004601	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
326427004602	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326427004603	MarR family; Region: MarR; pfam01047
326427004604	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
326427004605	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
326427004606	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
326427004607	Walker A/P-loop; other site
326427004608	ATP binding site [chemical binding]; other site
326427004609	Q-loop/lid; other site
326427004610	ABC transporter signature motif; other site
326427004611	Walker B; other site
326427004612	D-loop; other site
326427004613	H-loop/switch region; other site
326427004614	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
326427004615	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
326427004616	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
326427004617	Walker A/P-loop; other site
326427004618	ATP binding site [chemical binding]; other site
326427004619	Q-loop/lid; other site
326427004620	ABC transporter signature motif; other site
326427004621	Walker B; other site
326427004622	D-loop; other site
326427004623	H-loop/switch region; other site
326427004624	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
326427004625	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
326427004626	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
326427004627	ferric uptake regulator; Provisional; Region: fur; PRK09462
326427004628	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
326427004629	metal binding site 2 [ion binding]; metal-binding site
326427004630	putative DNA binding helix; other site
326427004631	metal binding site 1 [ion binding]; metal-binding site
326427004632	dimer interface [polypeptide binding]; other site
326427004633	structural Zn2+ binding site [ion binding]; other site
326427004634	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
326427004635	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
326427004636	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326427004637	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326427004638	active site
326427004639	ATP binding site [chemical binding]; other site
326427004640	substrate binding site [chemical binding]; other site
326427004641	Bacterial SH3 domain; Region: SH3_3; pfam08239
326427004642	4-aminobutyrate aminotransferase; Provisional; Region: PRK05769
326427004643	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
326427004644	inhibitor-cofactor binding pocket; inhibition site
326427004645	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427004646	catalytic residue [active]
326427004647	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
326427004648	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
326427004649	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
326427004650	ABC transporter; Region: ABC_tran_2; pfam12848
326427004651	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
326427004652	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
326427004653	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
326427004654	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
326427004655	active site
326427004656	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
326427004657	Domain of unknown function DUF21; Region: DUF21; pfam01595
326427004658	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
326427004659	Transporter associated domain; Region: CorC_HlyC; smart01091
326427004660	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
326427004661	active site
326427004662	catalytic motif [active]
326427004663	Zn binding site [ion binding]; other site
326427004664	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
326427004665	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
326427004666	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
326427004667	L11 interface [polypeptide binding]; other site
326427004668	putative EF-Tu interaction site [polypeptide binding]; other site
326427004669	putative EF-G interaction site [polypeptide binding]; other site
326427004670	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
326427004671	23S rRNA interface [nucleotide binding]; other site
326427004672	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
326427004673	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
326427004674	mRNA/rRNA interface [nucleotide binding]; other site
326427004675	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
326427004676	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
326427004677	23S rRNA interface [nucleotide binding]; other site
326427004678	L7/L12 interface [polypeptide binding]; other site
326427004679	putative thiostrepton binding site; other site
326427004680	L25 interface [polypeptide binding]; other site
326427004681	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
326427004682	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
326427004683	putative homodimer interface [polypeptide binding]; other site
326427004684	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
326427004685	heterodimer interface [polypeptide binding]; other site
326427004686	homodimer interface [polypeptide binding]; other site
326427004687	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
326427004688	elongation factor Tu; Reviewed; Region: PRK00049
326427004689	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
326427004690	G1 box; other site
326427004691	GEF interaction site [polypeptide binding]; other site
326427004692	GTP/Mg2+ binding site [chemical binding]; other site
326427004693	Switch I region; other site
326427004694	G2 box; other site
326427004695	G3 box; other site
326427004696	Switch II region; other site
326427004697	G4 box; other site
326427004698	G5 box; other site
326427004699	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
326427004700	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
326427004701	Antibiotic Binding Site [chemical binding]; other site
326427004702	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
326427004703	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
326427004704	putative NAD(P) binding site [chemical binding]; other site
326427004705	putative active site [active]
326427004706	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
326427004707	glucose-6-phosphate isomerase; Provisional; Region: PRK00973
326427004708	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
326427004709	active site
326427004710	dimer interface [polypeptide binding]; other site
326427004711	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
326427004712	dimer interface [polypeptide binding]; other site
326427004713	active site
326427004714	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
326427004715	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
326427004716	active site
326427004717	nucleotide binding site [chemical binding]; other site
326427004718	HIGH motif; other site
326427004719	KMSKS motif; other site
326427004720	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542
326427004721	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
326427004722	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
326427004723	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
326427004724	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
326427004725	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
326427004726	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
326427004727	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
326427004728	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
326427004729	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
326427004730	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427004731	Walker A motif; other site
326427004732	ATP binding site [chemical binding]; other site
326427004733	Walker B motif; other site
326427004734	arginine finger; other site
326427004735	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
326427004736	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
326427004737	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
326427004738	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326427004739	non-specific DNA binding site [nucleotide binding]; other site
326427004740	salt bridge; other site
326427004741	sequence-specific DNA binding site [nucleotide binding]; other site
326427004742	Cupin domain; Region: Cupin_2; pfam07883
326427004743	Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858
326427004744	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
326427004745	active site
326427004746	metal binding site [ion binding]; metal-binding site
326427004747	homotetramer interface [polypeptide binding]; other site
326427004748	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
326427004749	Low molecular weight phosphatase family; Region: LMWPc; cl00105
326427004750	active site
326427004751	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
326427004752	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
326427004753	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427004754	Coenzyme A binding pocket [chemical binding]; other site
326427004755	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427004756	Coenzyme A binding pocket [chemical binding]; other site
326427004757	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427004758	Coenzyme A binding pocket [chemical binding]; other site
326427004759	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
326427004760	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326427004761	motif II; other site
326427004762	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
326427004763	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
326427004764	Probable transposase; Region: OrfB_IS605; pfam01385
326427004765	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
326427004766	caa(3)-type oxidase, subunit IV; Region: caa3_sub_IV; TIGR02229
326427004767	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
326427004768	Subunit I/III interface [polypeptide binding]; other site
326427004769	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
326427004770	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
326427004771	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
326427004772	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
326427004773	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
326427004774	Cu(I) binding site [ion binding]; other site
326427004775	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
326427004776	heme-binding residues [chemical binding]; other site
326427004777	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
326427004778	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
326427004779	molybdopterin cofactor binding site; other site
326427004780	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
326427004781	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
326427004782	4Fe-4S binding domain; Region: Fer4_2; pfam12797
326427004783	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
326427004784	Cysteine-rich domain; Region: CCG; pfam02754
326427004785	Cysteine-rich domain; Region: CCG; pfam02754
326427004786	FAD binding domain; Region: FAD_binding_4; pfam01565
326427004787	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
326427004788	FAD binding domain; Region: FAD_binding_4; pfam01565
326427004789	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
326427004790	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
326427004791	FAD binding domain; Region: FAD_binding_4; pfam01565
326427004792	FAD binding domain; Region: FAD_binding_4; pfam01565
326427004793	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
326427004794	Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847
326427004795	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
326427004796	putative glycosyl transferase; Provisional; Region: PRK10307
326427004797	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
326427004798	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
326427004799	AMP binding site [chemical binding]; other site
326427004800	active site
326427004801	acyl-activating enzyme (AAE) consensus motif; other site
326427004802	CoA binding site [chemical binding]; other site
326427004803	YdjC-like protein; Region: YdjC; pfam04794
326427004804	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427004805	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
326427004806	putative glycosyl transferase; Provisional; Region: PRK10063
326427004807	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
326427004808	metal-binding site
326427004809	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
326427004810	active site
326427004811	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
326427004812	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
326427004813	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
326427004814	metal-binding site
326427004815	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
326427004816	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
326427004817	NADP binding site [chemical binding]; other site
326427004818	active site
326427004819	putative substrate binding site [chemical binding]; other site
326427004820	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
326427004821	extended (e) SDRs; Region: SDR_e; cd08946
326427004822	NAD(P) binding site [chemical binding]; other site
326427004823	active site
326427004824	substrate binding site [chemical binding]; other site
326427004825	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
326427004826	HlyD family secretion protein; Region: HlyD_3; pfam13437
326427004827	Chain length determinant protein; Region: Wzz; cl15801
326427004828	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
326427004829	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
326427004830	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427004831	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
326427004832	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
326427004833	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
326427004834	active site
326427004835	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
326427004836	putative trimer interface [polypeptide binding]; other site
326427004837	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
326427004838	trimer interface [polypeptide binding]; other site
326427004839	active site
326427004840	substrate binding site [chemical binding]; other site
326427004841	putative CoA binding site [chemical binding]; other site
326427004842	CoA binding site [chemical binding]; other site
326427004843	sulfotransferase; Region: PLN02164
326427004844	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
326427004845	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537
326427004846	ATP-sulfurylase; Region: ATPS; cd00517
326427004847	active site
326427004848	HXXH motif; other site
326427004849	flexible loop; other site
326427004850	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
326427004851	ligand-binding site [chemical binding]; other site
326427004852	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
326427004853	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
326427004854	NodB motif; other site
326427004855	active site
326427004856	catalytic site [active]
326427004857	metal binding site [ion binding]; metal-binding site
326427004858	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
326427004859	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
326427004860	active site
326427004861	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
326427004862	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
326427004863	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
326427004864	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
326427004865	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
326427004866	Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102
326427004867	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
326427004868	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
326427004869	Walker A/P-loop; other site
326427004870	ATP binding site [chemical binding]; other site
326427004871	Q-loop/lid; other site
326427004872	ABC transporter signature motif; other site
326427004873	Walker B; other site
326427004874	D-loop; other site
326427004875	H-loop/switch region; other site
326427004876	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
326427004877	putative carbohydrate binding site [chemical binding]; other site
326427004878	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
326427004879	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
326427004880	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
326427004881	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
326427004882	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
326427004883	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
326427004884	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
326427004885	dimer interface [polypeptide binding]; other site
326427004886	putative functional site; other site
326427004887	putative MPT binding site; other site
326427004888	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
326427004889	active site
326427004890	dimer interface [polypeptide binding]; other site
326427004891	metal binding site [ion binding]; metal-binding site
326427004892	Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834
326427004893	lycopene cyclase; Region: lycopene_cycl; TIGR01789
326427004894	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
326427004895	Uncharacterized conserved protein [Function unknown]; Region: COG2353
326427004896	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
326427004897	catalytic residues [active]
326427004898	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
326427004899	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326427004900	Histidine kinase; Region: HisKA_3; pfam07730
326427004901	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427004902	ATP binding site [chemical binding]; other site
326427004903	Mg2+ binding site [ion binding]; other site
326427004904	G-X-G motif; other site
326427004905	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
326427004906	acyl-CoA synthetase; Validated; Region: PRK08162
326427004907	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
326427004908	acyl-activating enzyme (AAE) consensus motif; other site
326427004909	putative active site [active]
326427004910	AMP binding site [chemical binding]; other site
326427004911	putative CoA binding site [chemical binding]; other site
326427004912	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427004913	binding surface
326427004914	Tetratricopeptide repeat; Region: TPR_16; pfam13432
326427004915	TPR motif; other site
326427004916	Peptidase family M23; Region: Peptidase_M23; pfam01551
326427004917	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
326427004918	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
326427004919	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
326427004920	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
326427004921	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
326427004922	putative Iron-sulfur protein interface [polypeptide binding]; other site
326427004923	proximal heme binding site [chemical binding]; other site
326427004924	distal heme binding site [chemical binding]; other site
326427004925	putative dimer interface [polypeptide binding]; other site
326427004926	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
326427004927	L-aspartate oxidase; Provisional; Region: PRK06175
326427004928	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
326427004929	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
326427004930	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
326427004931	catalytic loop [active]
326427004932	iron binding site [ion binding]; other site
326427004933	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427004934	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
326427004935	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
326427004936	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326427004937	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326427004938	catalytic residue [active]
326427004939	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
326427004940	Zn2+ binding site [ion binding]; other site
326427004941	Mg2+ binding site [ion binding]; other site
326427004942	Response regulator receiver domain; Region: Response_reg; pfam00072
326427004943	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427004944	active site
326427004945	phosphorylation site [posttranslational modification]
326427004946	intermolecular recognition site; other site
326427004947	dimerization interface [polypeptide binding]; other site
326427004948	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
326427004949	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
326427004950	DNA binding site [nucleotide binding]
326427004951	catalytic residue [active]
326427004952	H2TH interface [polypeptide binding]; other site
326427004953	putative catalytic residues [active]
326427004954	turnover-facilitating residue; other site
326427004955	intercalation triad [nucleotide binding]; other site
326427004956	8OG recognition residue [nucleotide binding]; other site
326427004957	putative reading head residues; other site
326427004958	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
326427004959	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
326427004960	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
326427004961	MoaE homodimer interface [polypeptide binding]; other site
326427004962	MoaD interaction [polypeptide binding]; other site
326427004963	active site residues [active]
326427004964	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
326427004965	MoaE interaction surface [polypeptide binding]; other site
326427004966	MoeB interaction surface [polypeptide binding]; other site
326427004967	thiocarboxylated glycine; other site
326427004968	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
326427004969	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427004970	NAD(P) binding site [chemical binding]; other site
326427004971	active site
326427004972	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
326427004973	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
326427004974	MoxR-like ATPases [General function prediction only]; Region: COG0714
326427004975	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427004976	Walker A motif; other site
326427004977	ATP binding site [chemical binding]; other site
326427004978	Walker B motif; other site
326427004979	arginine finger; other site
326427004980	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
326427004981	ATP-NAD kinase; Region: NAD_kinase; pfam01513
326427004982	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
326427004983	hydrophobic ligand binding site; other site
326427004984	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712
326427004985	amidase catalytic site [active]
326427004986	Zn binding residues [ion binding]; other site
326427004987	substrate binding site [chemical binding]; other site
326427004988	Cna protein B-type domain; Region: Cna_B_2; pfam13715
326427004989	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
326427004990	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
326427004991	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
326427004992	Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200
326427004993	Response regulator receiver domain; Region: Response_reg; pfam00072
326427004994	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427004995	active site
326427004996	phosphorylation site [posttranslational modification]
326427004997	intermolecular recognition site; other site
326427004998	dimerization interface [polypeptide binding]; other site
326427004999	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427005000	GAF domain; Region: GAF; pfam01590
326427005001	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427005002	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427005003	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427005004	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427005005	PAS domain; Region: PAS_9; pfam13426
326427005006	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
326427005007	cyclase homology domain; Region: CHD; cd07302
326427005008	nucleotidyl binding site; other site
326427005009	metal binding site [ion binding]; metal-binding site
326427005010	dimer interface [polypeptide binding]; other site
326427005011	putative anti-sigmaE protein; Provisional; Region: PRK13920
326427005012	Anti-sigma-K factor rskA; Region: RskA; pfam10099
326427005013	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326427005014	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326427005015	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
326427005016	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
326427005017	putative active site [active]
326427005018	Zn binding site [ion binding]; other site
326427005019	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
326427005020	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
326427005021	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
326427005022	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
326427005023	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
326427005024	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
326427005025	substrate binding pocket [chemical binding]; other site
326427005026	chain length determination region; other site
326427005027	substrate-Mg2+ binding site; other site
326427005028	catalytic residues [active]
326427005029	aspartate-rich region 1; other site
326427005030	active site lid residues [active]
326427005031	aspartate-rich region 2; other site
326427005032	Penicillinase repressor; Region: Pencillinase_R; pfam03965
326427005033	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
326427005034	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
326427005035	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326427005036	FeS/SAM binding site; other site
326427005037	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
326427005038	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
326427005039	Helix-turn-helix domain; Region: HTH_25; pfam13413
326427005040	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
326427005041	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
326427005042	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
326427005043	active site
326427005044	putative substrate binding pocket [chemical binding]; other site
326427005045	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
326427005046	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
326427005047	VanW like protein; Region: VanW; pfam04294
326427005048	G5 domain; Region: G5; pfam07501
326427005049	FOG: CBS domain [General function prediction only]; Region: COG0517
326427005050	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
326427005051	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
326427005052	iron binding site [ion binding]; other site
326427005053	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
326427005054	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
326427005055	tetramer interface [polypeptide binding]; other site
326427005056	TPP-binding site [chemical binding]; other site
326427005057	heterodimer interface [polypeptide binding]; other site
326427005058	phosphorylation loop region [posttranslational modification]
326427005059	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
326427005060	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
326427005061	alpha subunit interface [polypeptide binding]; other site
326427005062	TPP binding site [chemical binding]; other site
326427005063	heterodimer interface [polypeptide binding]; other site
326427005064	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
326427005065	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
326427005066	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
326427005067	E3 interaction surface; other site
326427005068	lipoyl attachment site [posttranslational modification]; other site
326427005069	e3 binding domain; Region: E3_binding; pfam02817
326427005070	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
326427005071	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
326427005072	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
326427005073	active site residue [active]
326427005074	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
326427005075	active site residue [active]
326427005076	short chain dehydrogenase; Provisional; Region: PRK06172
326427005077	classical (c) SDRs; Region: SDR_c; cd05233
326427005078	NAD(P) binding site [chemical binding]; other site
326427005079	active site
326427005080	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
326427005081	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
326427005082	NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008
326427005083	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
326427005084	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
326427005085	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
326427005086	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
326427005087	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
326427005088	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
326427005089	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
326427005090	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
326427005091	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
326427005092	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
326427005093	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
326427005094	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
326427005095	4Fe-4S binding domain; Region: Fer4; pfam00037
326427005096	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
326427005097	NADH dehydrogenase subunit D; Validated; Region: PRK06075
326427005098	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
326427005099	NADH dehydrogenase subunit B; Provisional; Region: PRK14819
326427005100	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
326427005101	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
326427005102	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326427005103	phosphopeptide binding site; other site
326427005104	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
326427005105	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326427005106	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
326427005107	phosphopeptide binding site; other site
326427005108	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
326427005109	Glycoprotease family; Region: Peptidase_M22; pfam00814
326427005110	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
326427005111	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
326427005112	Bacterial sugar transferase; Region: Bac_transf; pfam02397
326427005113	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
326427005114	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
326427005115	Probable Catalytic site; other site
326427005116	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326427005117	Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290
326427005118	subunit M interface; other site
326427005119	subunit H interface; other site
326427005120	quinone binding site; other site
326427005121	bacteriopheophytin binding site; other site
326427005122	bacteriochlorophyll binding site; other site
326427005123	cytochrome C subunit interface; other site
326427005124	Fe binding site [ion binding]; other site
326427005125	Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291
326427005126	subunit H interface; other site
326427005127	subunit L interface; other site
326427005128	bacteriopheophytin binding site; other site
326427005129	carotenoid binding site; other site
326427005130	bacteriochlorophyll binding site; other site
326427005131	cytochrome C interface; other site
326427005132	quinone binding site; other site
326427005133	Fe binding site [ion binding]; other site
326427005134	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
326427005135	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
326427005136	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
326427005137	ABC transporter; Region: ABC_tran_2; pfam12848
326427005138	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
326427005139	Methyltransferase domain; Region: Methyltransf_25; pfam13649
326427005140	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069
326427005141	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427005142	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
326427005143	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
326427005144	active site
326427005145	Divergent AAA domain; Region: AAA_4; pfam04326
326427005146	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
326427005147	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
326427005148	active site
326427005149	DNA binding site [nucleotide binding]
326427005150	Int/Topo IB signature motif; other site
326427005151	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
326427005152	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326427005153	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
326427005154	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
326427005155	GTPase CgtA; Reviewed; Region: obgE; PRK12297
326427005156	GTP1/OBG; Region: GTP1_OBG; pfam01018
326427005157	Obg GTPase; Region: Obg; cd01898
326427005158	G1 box; other site
326427005159	GTP/Mg2+ binding site [chemical binding]; other site
326427005160	Switch I region; other site
326427005161	G2 box; other site
326427005162	G3 box; other site
326427005163	Switch II region; other site
326427005164	G4 box; other site
326427005165	G5 box; other site
326427005166	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
326427005167	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
326427005168	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427005169	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
326427005170	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
326427005171	Catalytic site [active]
326427005172	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
326427005173	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
326427005174	Peptidase family U32; Region: Peptidase_U32; pfam01136
326427005175	Collagenase; Region: DUF3656; pfam12392
326427005176	Peptidase family U32; Region: Peptidase_U32; cl03113
326427005177	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
326427005178	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
326427005179	active sites [active]
326427005180	tetramer interface [polypeptide binding]; other site
326427005181	imidazolonepropionase; Validated; Region: PRK09356
326427005182	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
326427005183	active site
326427005184	urocanate hydratase; Provisional; Region: PRK05414
326427005185	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
326427005186	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
326427005187	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427005188	S-adenosylmethionine binding site [chemical binding]; other site
326427005189	multidrug resistance protein MdtH; Provisional; Region: PRK11646
326427005190	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
326427005191	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
326427005192	homodimer interface [polypeptide binding]; other site
326427005193	substrate-cofactor binding pocket; other site
326427005194	catalytic residue [active]
326427005195	N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184
326427005196	GMP synthase; Reviewed; Region: guaA; PRK00074
326427005197	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
326427005198	AMP/PPi binding site [chemical binding]; other site
326427005199	candidate oxyanion hole; other site
326427005200	catalytic triad [active]
326427005201	potential glutamine specificity residues [chemical binding]; other site
326427005202	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
326427005203	ATP Binding subdomain [chemical binding]; other site
326427005204	Ligand Binding sites [chemical binding]; other site
326427005205	Dimerization subdomain; other site
326427005206	cytidylate kinase; Provisional; Region: cmk; PRK00023
326427005207	AAA domain; Region: AAA_17; pfam13207
326427005208	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
326427005209	CMP-binding site; other site
326427005210	Bacterial PH domain; Region: DUF304; cl01348
326427005211	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
326427005212	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
326427005213	Walker A/P-loop; other site
326427005214	ATP binding site [chemical binding]; other site
326427005215	Q-loop/lid; other site
326427005216	ABC transporter signature motif; other site
326427005217	Walker B; other site
326427005218	D-loop; other site
326427005219	H-loop/switch region; other site
326427005220	Protein of unknown function (DUF1636); Region: DUF1636; cl17843
326427005221	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
326427005222	putative dimer interface [polypeptide binding]; other site
326427005223	[2Fe-2S] cluster binding site [ion binding]; other site
326427005224	adenylosuccinate lyase; Provisional; Region: PRK09285
326427005225	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
326427005226	tetramer interface [polypeptide binding]; other site
326427005227	active site
326427005228	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326427005229	MarR family; Region: MarR_2; cl17246
326427005230	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
326427005231	HlyD family secretion protein; Region: HlyD_3; pfam13437
326427005232	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
326427005233	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
326427005234	FtsX-like permease family; Region: FtsX; pfam02687
326427005235	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
326427005236	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427005237	NAD(P) binding site [chemical binding]; other site
326427005238	active site
326427005239	GAF domain; Region: GAF; cl17456
326427005240	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427005241	GAF domain; Region: GAF_3; pfam13492
326427005242	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
326427005243	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427005244	putative active site [active]
326427005245	heme pocket [chemical binding]; other site
326427005246	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427005247	dimer interface [polypeptide binding]; other site
326427005248	phosphorylation site [posttranslational modification]
326427005249	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427005250	ATP binding site [chemical binding]; other site
326427005251	Mg2+ binding site [ion binding]; other site
326427005252	G-X-G motif; other site
326427005253	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
326427005254	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326427005255	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427005256	homodimer interface [polypeptide binding]; other site
326427005257	catalytic residue [active]
326427005258	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
326427005259	Double zinc ribbon; Region: DZR; pfam12773
326427005260	Transcriptional regulators [Transcription]; Region: MarR; COG1846
326427005261	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
326427005262	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
326427005263	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
326427005264	Walker A/P-loop; other site
326427005265	ATP binding site [chemical binding]; other site
326427005266	Q-loop/lid; other site
326427005267	ABC transporter signature motif; other site
326427005268	Walker B; other site
326427005269	D-loop; other site
326427005270	H-loop/switch region; other site
326427005271	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
326427005272	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
326427005273	Transcriptional regulators [Transcription]; Region: PurR; COG1609
326427005274	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
326427005275	DNA binding site [nucleotide binding]
326427005276	domain linker motif; other site
326427005277	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
326427005278	putative dimerization interface [polypeptide binding]; other site
326427005279	putative ligand binding site [chemical binding]; other site
326427005280	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
326427005281	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
326427005282	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427005283	dimer interface [polypeptide binding]; other site
326427005284	conserved gate region; other site
326427005285	putative PBP binding loops; other site
326427005286	ABC-ATPase subunit interface; other site
326427005287	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
326427005288	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427005289	dimer interface [polypeptide binding]; other site
326427005290	conserved gate region; other site
326427005291	putative PBP binding loops; other site
326427005292	ABC-ATPase subunit interface; other site
326427005293	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
326427005294	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
326427005295	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
326427005296	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
326427005297	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
326427005298	active site
326427005299	catalytic residues [active]
326427005300	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
326427005301	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
326427005302	PA14 domain; Region: PA14; cl08459
326427005303	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
326427005304	conserved hypothetical protein; Region: TIGR03843
326427005305	conserved hypothetical protein; Region: TIGR03847
326427005306	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
326427005307	catalytic core [active]
326427005308	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
326427005309	Domain of unknown function (DUF3524); Region: DUF3524; pfam12038
326427005310	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427005311	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326427005312	LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cd08368
326427005313	Zn binding site [ion binding]; other site
326427005314	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
326427005315	Predicted esterase [General function prediction only]; Region: COG0400
326427005316	putative hydrolase; Provisional; Region: PRK11460
326427005317	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
326427005318	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
326427005319	Transcriptional regulator [Transcription]; Region: LytR; COG1316
326427005320	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
326427005321	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
326427005322	Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131
326427005323	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326427005324	NAD binding site [chemical binding]; other site
326427005325	catalytic residues [active]
326427005326	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
326427005327	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
326427005328	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
326427005329	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
326427005330	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
326427005331	Cache domain; Region: Cache_1; pfam02743
326427005332	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326427005333	dimerization interface [polypeptide binding]; other site
326427005334	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427005335	dimer interface [polypeptide binding]; other site
326427005336	phosphorylation site [posttranslational modification]
326427005337	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427005338	ATP binding site [chemical binding]; other site
326427005339	Mg2+ binding site [ion binding]; other site
326427005340	G-X-G motif; other site
326427005341	Response regulator receiver domain; Region: Response_reg; pfam00072
326427005342	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427005343	active site
326427005344	phosphorylation site [posttranslational modification]
326427005345	intermolecular recognition site; other site
326427005346	dimerization interface [polypeptide binding]; other site
326427005347	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
326427005348	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427005349	active site
326427005350	phosphorylation site [posttranslational modification]
326427005351	intermolecular recognition site; other site
326427005352	dimerization interface [polypeptide binding]; other site
326427005353	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
326427005354	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427005355	active site
326427005356	phosphorylation site [posttranslational modification]
326427005357	intermolecular recognition site; other site
326427005358	dimerization interface [polypeptide binding]; other site
326427005359	Tetratricopeptide repeat; Region: TPR_9; pfam13371
326427005360	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
326427005361	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
326427005362	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
326427005363	N-acetyl-D-glucosamine binding site [chemical binding]; other site
326427005364	catalytic residue [active]
326427005365	PAS domain; Region: PAS_8; pfam13188
326427005366	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427005367	Cytochrome c; Region: Cytochrom_C; cl11414
326427005368	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
326427005369	MutS domain III; Region: MutS_III; pfam05192
326427005370	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
326427005371	Walker A/P-loop; other site
326427005372	ATP binding site [chemical binding]; other site
326427005373	Q-loop/lid; other site
326427005374	ABC transporter signature motif; other site
326427005375	Walker B; other site
326427005376	D-loop; other site
326427005377	H-loop/switch region; other site
326427005378	Smr domain; Region: Smr; pfam01713
326427005379	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326427005380	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427005381	putative substrate translocation pore; other site
326427005382	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
326427005383	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
326427005384	dimer interface [polypeptide binding]; other site
326427005385	active site
326427005386	ribonuclease III; Reviewed; Region: rnc; PRK00102
326427005387	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
326427005388	dimerization interface [polypeptide binding]; other site
326427005389	active site
326427005390	metal binding site [ion binding]; metal-binding site
326427005391	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
326427005392	dsRNA binding site [nucleotide binding]; other site
326427005393	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427005394	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
326427005395	NAD(P) binding site [chemical binding]; other site
326427005396	active site
326427005397	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260
326427005398	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
326427005399	putative NAD(P) binding site [chemical binding]; other site
326427005400	catalytic Zn binding site [ion binding]; other site
326427005401	structural Zn binding site [ion binding]; other site
326427005402	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
326427005403	Part of AAA domain; Region: AAA_19; pfam13245
326427005404	Family description; Region: UvrD_C_2; pfam13538
326427005405	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326427005406	active site
326427005407	ATP binding site [chemical binding]; other site
326427005408	substrate binding site [chemical binding]; other site
326427005409	activation loop (A-loop); other site
326427005410	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
326427005411	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
326427005412	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
326427005413	C-terminal peptidase (prc); Region: prc; TIGR00225
326427005414	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
326427005415	protein binding site [polypeptide binding]; other site
326427005416	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
326427005417	Catalytic dyad [active]
326427005418	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
326427005419	RNA methyltransferase, RsmE family; Region: TIGR00046
326427005420	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
326427005421	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
326427005422	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
326427005423	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
326427005424	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
326427005425	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
326427005426	active site
326427005427	HIGH motif; other site
326427005428	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
326427005429	KMSKS motif; other site
326427005430	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
326427005431	tRNA binding surface [nucleotide binding]; other site
326427005432	anticodon binding site; other site
326427005433	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
326427005434	serine O-acetyltransferase; Region: cysE; TIGR01172
326427005435	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
326427005436	trimer interface [polypeptide binding]; other site
326427005437	active site
326427005438	substrate binding site [chemical binding]; other site
326427005439	CoA binding site [chemical binding]; other site
326427005440	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
326427005441	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
326427005442	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326427005443	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326427005444	catalytic residue [active]
326427005445	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
326427005446	Type II/IV secretion system protein; Region: T2SE; pfam00437
326427005447	Walker A motif; other site
326427005448	ATP binding site [chemical binding]; other site
326427005449	Walker B motif; other site
326427005450	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
326427005451	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
326427005452	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
326427005453	Walker A motif; other site
326427005454	ATP binding site [chemical binding]; other site
326427005455	Walker B motif; other site
326427005456	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
326427005457	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
326427005458	TadE-like protein; Region: TadE; pfam07811
326427005459	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
326427005460	Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504
326427005461	Domain of unknown function DUF11; Region: DUF11; pfam01345
326427005462	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
326427005463	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
326427005464	active site
326427005465	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
326427005466	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
326427005467	Probable transposase; Region: OrfB_IS605; pfam01385
326427005468	Transposase IS200 like; Region: Y1_Tnp; pfam01797
326427005469	CTP synthetase; Validated; Region: pyrG; PRK05380
326427005470	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
326427005471	active site
326427005472	UTP binding site [chemical binding]; other site
326427005473	Catalytic site [active]
326427005474	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
326427005475	active site
326427005476	putative oxyanion hole; other site
326427005477	catalytic triad [active]
326427005478	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
326427005479	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
326427005480	envelope glycoprotein C; Provisional; Region: PHA03269
326427005481	RecX family; Region: RecX; cl00936
326427005482	recombinase A; Provisional; Region: recA; PRK09354
326427005483	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
326427005484	hexamer interface [polypeptide binding]; other site
326427005485	Walker A motif; other site
326427005486	ATP binding site [chemical binding]; other site
326427005487	Walker B motif; other site
326427005488	Domain of unknown function (DUF427); Region: DUF427; pfam04248
326427005489	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
326427005490	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
326427005491	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
326427005492	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
326427005493	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427005494	putative PBP binding loops; other site
326427005495	dimer interface [polypeptide binding]; other site
326427005496	ABC-ATPase subunit interface; other site
326427005497	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
326427005498	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
326427005499	Walker A/P-loop; other site
326427005500	ATP binding site [chemical binding]; other site
326427005501	Q-loop/lid; other site
326427005502	ABC transporter signature motif; other site
326427005503	Walker B; other site
326427005504	D-loop; other site
326427005505	H-loop/switch region; other site
326427005506	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326427005507	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
326427005508	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
326427005509	Walker A/P-loop; other site
326427005510	ATP binding site [chemical binding]; other site
326427005511	Q-loop/lid; other site
326427005512	ABC transporter signature motif; other site
326427005513	Walker B; other site
326427005514	D-loop; other site
326427005515	H-loop/switch region; other site
326427005516	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326427005517	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
326427005518	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427005519	dimer interface [polypeptide binding]; other site
326427005520	conserved gate region; other site
326427005521	putative PBP binding loops; other site
326427005522	ABC-ATPase subunit interface; other site
326427005523	Transposase IS200 like; Region: Y1_Tnp; pfam01797
326427005524	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
326427005525	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
326427005526	Probable transposase; Region: OrfB_IS605; pfam01385
326427005527	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
326427005528	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
326427005529	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
326427005530	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
326427005531	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
326427005532	Walker A/P-loop; other site
326427005533	ATP binding site [chemical binding]; other site
326427005534	Q-loop/lid; other site
326427005535	ABC transporter signature motif; other site
326427005536	Walker B; other site
326427005537	D-loop; other site
326427005538	H-loop/switch region; other site
326427005539	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
326427005540	Peptidase family M23; Region: Peptidase_M23; pfam01551
326427005541	Transposase IS200 like; Region: Y1_Tnp; pfam01797
326427005542	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
326427005543	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
326427005544	active site
326427005545	tetramer interface [polypeptide binding]; other site
326427005546	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
326427005547	active site
326427005548	Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481
326427005549	active site
326427005550	catalytic triad [active]
326427005551	Histidine kinase; Region: HisKA_3; pfam07730
326427005552	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
326427005553	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326427005554	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427005555	active site
326427005556	phosphorylation site [posttranslational modification]
326427005557	intermolecular recognition site; other site
326427005558	dimerization interface [polypeptide binding]; other site
326427005559	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326427005560	DNA binding residues [nucleotide binding]
326427005561	dimerization interface [polypeptide binding]; other site
326427005562	cyclase homology domain; Region: CHD; cd07302
326427005563	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
326427005564	nucleotidyl binding site; other site
326427005565	metal binding site [ion binding]; metal-binding site
326427005566	dimer interface [polypeptide binding]; other site
326427005567	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
326427005568	cyclase homology domain; Region: CHD; cd07302
326427005569	nucleotidyl binding site; other site
326427005570	metal binding site [ion binding]; metal-binding site
326427005571	dimer interface [polypeptide binding]; other site
326427005572	AAA ATPase domain; Region: AAA_16; pfam13191
326427005573	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427005574	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427005575	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427005576	binding surface
326427005577	TPR motif; other site
326427005578	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427005579	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427005580	Quinolinate synthetase A protein; Region: NadA; pfam02445
326427005581	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
326427005582	L-aspartate oxidase; Provisional; Region: PRK06175
326427005583	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
326427005584	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
326427005585	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
326427005586	dimerization interface [polypeptide binding]; other site
326427005587	active site
326427005588	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
326427005589	GAF domain; Region: GAF_2; pfam13185
326427005590	GAF domain; Region: GAF_3; pfam13492
326427005591	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
326427005592	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427005593	dimer interface [polypeptide binding]; other site
326427005594	phosphorylation site [posttranslational modification]
326427005595	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427005596	ATP binding site [chemical binding]; other site
326427005597	Mg2+ binding site [ion binding]; other site
326427005598	G-X-G motif; other site
326427005599	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326427005600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427005601	active site
326427005602	phosphorylation site [posttranslational modification]
326427005603	intermolecular recognition site; other site
326427005604	dimerization interface [polypeptide binding]; other site
326427005605	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326427005606	DNA binding site [nucleotide binding]
326427005607	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
326427005608	dimer interface [polypeptide binding]; other site
326427005609	active site
326427005610	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
326427005611	catalytic residues [active]
326427005612	substrate binding site [chemical binding]; other site
326427005613	amidase; Provisional; Region: PRK08137
326427005614	Amidase; Region: Amidase; cl11426
326427005615	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
326427005616	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
326427005617	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
326427005618	Peptidase M16C associated; Region: M16C_assoc; pfam08367
326427005619	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
326427005620	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326427005621	active site
326427005622	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
326427005623	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
326427005624	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427005625	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326427005626	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427005627	Domain of unknown function (DUF385); Region: DUF385; pfam04075
326427005628	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
326427005629	Integral membrane protein DUF95; Region: DUF95; pfam01944
326427005630	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
326427005631	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
326427005632	Walker A/P-loop; other site
326427005633	ATP binding site [chemical binding]; other site
326427005634	Q-loop/lid; other site
326427005635	ABC transporter signature motif; other site
326427005636	Walker B; other site
326427005637	D-loop; other site
326427005638	H-loop/switch region; other site
326427005639	glutamine synthetase, type I; Region: GlnA; TIGR00653
326427005640	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
326427005641	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
326427005642	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
326427005643	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
326427005644	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
326427005645	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
326427005646	Ligand binding site; other site
326427005647	Putative Catalytic site; other site
326427005648	DXD motif; other site
326427005649	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
326427005650	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
326427005651	Multicopper oxidase; Region: Cu-oxidase; pfam00394
326427005652	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
326427005653	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326427005654	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
326427005655	ligand binding site [chemical binding]; other site
326427005656	flexible hinge region; other site
326427005657	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
326427005658	putative switch regulator; other site
326427005659	non-specific DNA interactions [nucleotide binding]; other site
326427005660	DNA binding site [nucleotide binding]
326427005661	sequence specific DNA binding site [nucleotide binding]; other site
326427005662	putative cAMP binding site [chemical binding]; other site
326427005663	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
326427005664	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
326427005665	enoyl-CoA hydratase; Provisional; Region: PRK05995
326427005666	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326427005667	substrate binding site [chemical binding]; other site
326427005668	oxyanion hole (OAH) forming residues; other site
326427005669	trimer interface [polypeptide binding]; other site
326427005670	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
326427005671	MoxR-like ATPases [General function prediction only]; Region: COG0714
326427005672	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427005673	Walker A motif; other site
326427005674	ATP binding site [chemical binding]; other site
326427005675	Walker B motif; other site
326427005676	arginine finger; other site
326427005677	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
326427005678	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
326427005679	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
326427005680	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
326427005681	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
326427005682	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326427005683	ATP binding site [chemical binding]; other site
326427005684	putative Mg++ binding site [ion binding]; other site
326427005685	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
326427005686	Protein of unknown function DUF45; Region: DUF45; cl00636
326427005687	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
326427005688	putative active site [active]
326427005689	NB-ARC domain; Region: NB-ARC; pfam00931
326427005690	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
326427005691	PQQ-like domain; Region: PQQ_2; pfam13360
326427005692	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326427005693	structural tetrad; other site
326427005694	PQQ-like domain; Region: PQQ_2; pfam13360
326427005695	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326427005696	structural tetrad; other site
326427005697	FOG: WD40 repeat [General function prediction only]; Region: COG2319
326427005698	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326427005699	structural tetrad; other site
326427005700	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326427005701	structural tetrad; other site
326427005702	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
326427005703	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
326427005704	substrate binding site; other site
326427005705	metal-binding site
326427005706	Oligomer interface; other site
326427005707	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
326427005708	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
326427005709	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
326427005710	inhibitor site; inhibition site
326427005711	active site
326427005712	dimer interface [polypeptide binding]; other site
326427005713	catalytic residue [active]
326427005714	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
326427005715	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
326427005716	aspartate kinase; Provisional; Region: PRK06291
326427005717	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
326427005718	nucleotide binding site [chemical binding]; other site
326427005719	substrate binding site [chemical binding]; other site
326427005720	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
326427005721	dimer interface [polypeptide binding]; other site
326427005722	putative threonine allosteric regulatory site; other site
326427005723	ACT domains of a monofunctional aspartokinase found mostly in Archaea species (ACT_AK-Arch_2); Region: ACT_AK-Arch_2; cd04924
326427005724	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
326427005725	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
326427005726	NADP binding site [chemical binding]; other site
326427005727	dimer interface [polypeptide binding]; other site
326427005728	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427005729	CpXC protein; Region: CpXC; pfam14353
326427005730	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
326427005731	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
326427005732	putative active site [active]
326427005733	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
326427005734	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
326427005735	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326427005736	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
326427005737	anti sigma factor interaction site; other site
326427005738	regulatory phosphorylation site [posttranslational modification]; other site
326427005739	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
326427005740	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
326427005741	DXD motif; other site
326427005742	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326427005743	Bacterial cellulose synthase subunit; Region: BcsB; pfam03170
326427005744	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
326427005745	putative binding surface; other site
326427005746	active site
326427005747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
326427005748	active site
326427005749	phosphorylation site [posttranslational modification]
326427005750	intermolecular recognition site; other site
326427005751	dimerization interface [polypeptide binding]; other site
326427005752	Response regulator receiver domain; Region: Response_reg; pfam00072
326427005753	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427005754	active site
326427005755	phosphorylation site [posttranslational modification]
326427005756	intermolecular recognition site; other site
326427005757	dimerization interface [polypeptide binding]; other site
326427005758	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
326427005759	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326427005760	metal binding site [ion binding]; metal-binding site
326427005761	active site
326427005762	I-site; other site
326427005763	Response regulator receiver domain; Region: Response_reg; pfam00072
326427005764	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427005765	active site
326427005766	phosphorylation site [posttranslational modification]
326427005767	intermolecular recognition site; other site
326427005768	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
326427005769	dimerization interface [polypeptide binding]; other site
326427005770	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
326427005771	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
326427005772	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
326427005773	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427005774	threonine synthase; Validated; Region: PRK06260
326427005775	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
326427005776	homodimer interface [polypeptide binding]; other site
326427005777	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427005778	catalytic residue [active]
326427005779	YceG-like family; Region: YceG; pfam02618
326427005780	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
326427005781	dimerization interface [polypeptide binding]; other site
326427005782	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
326427005783	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
326427005784	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
326427005785	NAD(P) binding site [chemical binding]; other site
326427005786	shikimate binding site; other site
326427005787	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
326427005788	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
326427005789	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
326427005790	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326427005791	active site
326427005792	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
326427005793	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
326427005794	GDP-binding site [chemical binding]; other site
326427005795	ACT binding site; other site
326427005796	IMP binding site; other site
326427005797	acetylornithine aminotransferase; Provisional; Region: PRK02627
326427005798	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
326427005799	inhibitor-cofactor binding pocket; inhibition site
326427005800	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427005801	catalytic residue [active]
326427005802	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427005803	S-adenosylmethionine binding site [chemical binding]; other site
326427005804	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
326427005805	RNA/DNA hybrid binding site [nucleotide binding]; other site
326427005806	active site
326427005807	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427005808	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427005809	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
326427005810	Clp amino terminal domain; Region: Clp_N; pfam02861
326427005811	Clp amino terminal domain; Region: Clp_N; pfam02861
326427005812	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427005813	Walker A motif; other site
326427005814	ATP binding site [chemical binding]; other site
326427005815	Walker B motif; other site
326427005816	arginine finger; other site
326427005817	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427005818	Walker A motif; other site
326427005819	ATP binding site [chemical binding]; other site
326427005820	Walker B motif; other site
326427005821	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
326427005822	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
326427005823	CcmE; Region: CcmE; cl00994
326427005824	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
326427005825	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
326427005826	DnaJ domain; Region: DnaJ; pfam00226
326427005827	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
326427005828	binding surface
326427005829	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
326427005830	DnaJ domain; Region: DnaJ; pfam00226
326427005831	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
326427005832	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
326427005833	catalytic residues [active]
326427005834	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326427005835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427005836	active site
326427005837	phosphorylation site [posttranslational modification]
326427005838	intermolecular recognition site; other site
326427005839	dimerization interface [polypeptide binding]; other site
326427005840	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326427005841	DNA binding site [nucleotide binding]
326427005842	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
326427005843	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
326427005844	Walker A/P-loop; other site
326427005845	ATP binding site [chemical binding]; other site
326427005846	Q-loop/lid; other site
326427005847	ABC transporter signature motif; other site
326427005848	Walker B; other site
326427005849	D-loop; other site
326427005850	H-loop/switch region; other site
326427005851	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
326427005852	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
326427005853	Walker A/P-loop; other site
326427005854	ATP binding site [chemical binding]; other site
326427005855	Q-loop/lid; other site
326427005856	ABC transporter signature motif; other site
326427005857	Walker B; other site
326427005858	D-loop; other site
326427005859	H-loop/switch region; other site
326427005860	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
326427005861	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
326427005862	TM-ABC transporter signature motif; other site
326427005863	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
326427005864	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
326427005865	TM-ABC transporter signature motif; other site
326427005866	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
326427005867	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
326427005868	dimerization interface [polypeptide binding]; other site
326427005869	ligand binding site [chemical binding]; other site
326427005870	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
326427005871	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
326427005872	dimerization interface [polypeptide binding]; other site
326427005873	ligand binding site [chemical binding]; other site
326427005874	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
326427005875	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
326427005876	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
326427005877	catalytic residue [active]
326427005878	UGMP family protein; Validated; Region: PRK09604
326427005879	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
326427005880	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
326427005881	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
326427005882	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
326427005883	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
326427005884	Zn2+ binding site [ion binding]; other site
326427005885	Mg2+ binding site [ion binding]; other site
326427005886	Yqey-like protein; Region: YqeY; cl17540
326427005887	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
326427005888	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
326427005889	catalytic site [active]
326427005890	G-X2-G-X-G-K; other site
326427005891	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
326427005892	Domain of unknown function (DUF814); Region: DUF814; pfam05670
326427005893	Ferredoxin [Energy production and conversion]; Region: COG1146
326427005894	4Fe-4S binding domain; Region: Fer4; cl02805
326427005895	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
326427005896	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
326427005897	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
326427005898	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
326427005899	AAK_NAGK-UC: N-Acetyl-L-glutamate kinase - uncharacterized (NAGK-UC). This domain is similar to Escherichia coli and Pseudomonas aeruginosa NAGKs which catalyze the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the...; Region: AAK_NAGK-UC; cd04251
326427005900	putative nucleotide binding site [chemical binding]; other site
326427005901	putative N-acetyl-L-glutamate binding site [chemical binding]; other site
326427005902	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
326427005903	active site
326427005904	metal binding site [ion binding]; metal-binding site
326427005905	uncharacterized subgroup of the Peptidase C25 family N-terminal domain; Region: Peptidase_C25_N_1; cd10914
326427005906	putative active site [active]
326427005907	conserved repeat domain; Region: B_ant_repeat; TIGR01451
326427005908	Domain of unknown function DUF11; Region: DUF11; pfam01345
326427005909	Domain of unknown function DUF11; Region: DUF11; pfam01345
326427005910	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326427005911	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
326427005912	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
326427005913	TPP-binding site [chemical binding]; other site
326427005914	dimer interface [polypeptide binding]; other site
326427005915	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
326427005916	PYR/PP interface [polypeptide binding]; other site
326427005917	dimer interface [polypeptide binding]; other site
326427005918	TPP binding site [chemical binding]; other site
326427005919	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
326427005920	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
326427005921	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
326427005922	substrate binding site [chemical binding]; other site
326427005923	glutamase interaction surface [polypeptide binding]; other site
326427005924	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
326427005925	DHH family; Region: DHH; pfam01368
326427005926	DHHA1 domain; Region: DHHA1; pfam02272
326427005927	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
326427005928	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
326427005929	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326427005930	dimerization interface [polypeptide binding]; other site
326427005931	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427005932	dimer interface [polypeptide binding]; other site
326427005933	phosphorylation site [posttranslational modification]
326427005934	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
326427005935	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
326427005936	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427005937	active site
326427005938	phosphorylation site [posttranslational modification]
326427005939	intermolecular recognition site; other site
326427005940	phosphoglyceromutase; Provisional; Region: PRK05434
326427005941	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
326427005942	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
326427005943	FAD binding domain; Region: FAD_binding_4; pfam01565
326427005944	FAD binding domain; Region: FAD_binding_4; pfam01565
326427005945	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
326427005946	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
326427005947	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
326427005948	Ligand binding site; other site
326427005949	Putative Catalytic site; other site
326427005950	DXD motif; other site
326427005951	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
326427005952	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326427005953	ligand binding site [chemical binding]; other site
326427005954	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
326427005955	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
326427005956	peptide binding site [polypeptide binding]; other site
326427005957	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
326427005958	dimer interface [polypeptide binding]; other site
326427005959	RNA helicase; Region: RNA_helicase; pfam00910
326427005960	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
326427005961	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
326427005962	putative dimer interface [polypeptide binding]; other site
326427005963	putative anticodon binding site; other site
326427005964	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
326427005965	homodimer interface [polypeptide binding]; other site
326427005966	motif 1; other site
326427005967	motif 2; other site
326427005968	active site
326427005969	motif 3; other site
326427005970	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
326427005971	M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896
326427005972	putative metal binding site [ion binding]; other site
326427005973	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
326427005974	active site
326427005975	catalytic site [active]
326427005976	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427005977	S-adenosylmethionine binding site [chemical binding]; other site
326427005978	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
326427005979	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
326427005980	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
326427005981	RNA/DNA hybrid binding site [nucleotide binding]; other site
326427005982	active site
326427005983	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
326427005984	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
326427005985	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
326427005986	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326427005987	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
326427005988	phosphopeptide binding site; other site
326427005989	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427005990	GAF domain; Region: GAF; pfam01590
326427005991	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
326427005992	cyclase homology domain; Region: CHD; cd07302
326427005993	nucleotidyl binding site; other site
326427005994	metal binding site [ion binding]; metal-binding site
326427005995	dimer interface [polypeptide binding]; other site
326427005996	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
326427005997	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
326427005998	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
326427005999	Part of AAA domain; Region: AAA_19; pfam13245
326427006000	Family description; Region: UvrD_C_2; pfam13538
326427006001	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
326427006002	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
326427006003	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
326427006004	dimerization interface [polypeptide binding]; other site
326427006005	Sensor protein DegS; Region: DegS; pfam05384
326427006006	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326427006007	Histidine kinase; Region: HisKA_3; pfam07730
326427006008	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427006009	ATP binding site [chemical binding]; other site
326427006010	Mg2+ binding site [ion binding]; other site
326427006011	G-X-G motif; other site
326427006012	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427006013	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326427006014	putative substrate translocation pore; other site
326427006015	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427006016	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
326427006017	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326427006018	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
326427006019	phosphopeptide binding site; other site
326427006020	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
326427006021	FOG: CBS domain [General function prediction only]; Region: COG0517
326427006022	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
326427006023	CBS domain; Region: CBS; pfam00571
326427006024	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
326427006025	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427006026	NAD(P) binding site [chemical binding]; other site
326427006027	active site
326427006028	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427006029	PAS fold; Region: PAS_3; pfam08447
326427006030	putative active site [active]
326427006031	heme pocket [chemical binding]; other site
326427006032	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427006033	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
326427006034	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427006035	NAD(P) binding site [chemical binding]; other site
326427006036	active site
326427006037	Oligomerisation domain; Region: Oligomerisation; pfam02410
326427006038	Uncharacterized conserved protein [Function unknown]; Region: COG1432
326427006039	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
326427006040	putative metal binding site [ion binding]; other site
326427006041	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
326427006042	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
326427006043	putative ADP-ribose binding site [chemical binding]; other site
326427006044	putative active site [active]
326427006045	PspC domain; Region: PspC; pfam04024
326427006046	Integral membrane protein DUF92; Region: DUF92; pfam01940
326427006047	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
326427006048	hydrophobic ligand binding site; other site
326427006049	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
326427006050	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427006051	putative substrate translocation pore; other site
326427006052	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
326427006053	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427006054	Coenzyme A binding pocket [chemical binding]; other site
326427006055	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
326427006056	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
326427006057	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
326427006058	Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720
326427006059	VanW like protein; Region: VanW; pfam04294
326427006060	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_8; cd06905
326427006061	putative active site [active]
326427006062	Zn binding site [ion binding]; other site
326427006063	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
326427006064	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
326427006065	active site
326427006066	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
326427006067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427006068	ATP binding site [chemical binding]; other site
326427006069	Mg2+ binding site [ion binding]; other site
326427006070	G-X-G motif; other site
326427006071	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
326427006072	ATP binding site [chemical binding]; other site
326427006073	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
326427006074	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
326427006075	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
326427006076	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
326427006077	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326427006078	catalytic residue [active]
326427006079	CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766
326427006080	NMT1/THI5 like; Region: NMT1; pfam09084
326427006081	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
326427006082	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
326427006083	active site
326427006084	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
326427006085	FAD binding site [chemical binding]; other site
326427006086	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
326427006087	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
326427006088	homodimer interface [polypeptide binding]; other site
326427006089	substrate-cofactor binding pocket; other site
326427006090	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427006091	catalytic residue [active]
326427006092	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
326427006093	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427006094	Coenzyme A binding pocket [chemical binding]; other site
326427006095	beta-ketothiolase; Provisional; Region: PRK09051
326427006096	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
326427006097	dimer interface [polypeptide binding]; other site
326427006098	active site
326427006099	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326427006100	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427006101	NAD(P) binding site [chemical binding]; other site
326427006102	active site
326427006103	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
326427006104	Bacterial transcriptional activator domain; Region: BTAD; smart01043
326427006105	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
326427006106	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
326427006107	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
326427006108	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
326427006109	putative active site [active]
326427006110	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
326427006111	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
326427006112	putative ADP-binding pocket [chemical binding]; other site
326427006113	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
326427006114	Ligand binding site; other site
326427006115	Putative Catalytic site; other site
326427006116	DXD motif; other site
326427006117	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
326427006118	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
326427006119	active site
326427006120	dimer interface [polypeptide binding]; other site
326427006121	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
326427006122	Ligand Binding Site [chemical binding]; other site
326427006123	Molecular Tunnel; other site
326427006124	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
326427006125	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427006126	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
326427006127	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
326427006128	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427006129	S-adenosylmethionine binding site [chemical binding]; other site
326427006130	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
326427006131	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
326427006132	inhibitor-cofactor binding pocket; inhibition site
326427006133	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427006134	catalytic residue [active]
326427006135	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326427006136	putative trimer interface [polypeptide binding]; other site
326427006137	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
326427006138	putative CoA binding site [chemical binding]; other site
326427006139	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
326427006140	putative trimer interface [polypeptide binding]; other site
326427006141	putative active site [active]
326427006142	putative substrate binding site [chemical binding]; other site
326427006143	putative CoA binding site [chemical binding]; other site
326427006144	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
326427006145	active site
326427006146	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
326427006147	homodimer interface [polypeptide binding]; other site
326427006148	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
326427006149	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
326427006150	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
326427006151	Ligand binding site; other site
326427006152	Putative Catalytic site; other site
326427006153	DXD motif; other site
326427006154	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
326427006155	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
326427006156	Bacterial sugar transferase; Region: Bac_transf; pfam02397
326427006157	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326427006158	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427006159	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
326427006160	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
326427006161	putative trimer interface [polypeptide binding]; other site
326427006162	putative active site [active]
326427006163	putative substrate binding site [chemical binding]; other site
326427006164	putative CoA binding site [chemical binding]; other site
326427006165	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
326427006166	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
326427006167	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
326427006168	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
326427006169	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
326427006170	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
326427006171	NAD binding site [chemical binding]; other site
326427006172	homotetramer interface [polypeptide binding]; other site
326427006173	homodimer interface [polypeptide binding]; other site
326427006174	active site
326427006175	substrate binding site [chemical binding]; other site
326427006176	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
326427006177	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
326427006178	active site
326427006179	substrate binding site [chemical binding]; other site
326427006180	metal binding site [ion binding]; metal-binding site
326427006181	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
326427006182	active site
326427006183	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
326427006184	metal binding site [ion binding]; metal-binding site
326427006185	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
326427006186	phosphate binding site [ion binding]; other site
326427006187	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
326427006188	active site
326427006189	catalytic triad [active]
326427006190	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
326427006191	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
326427006192	NAD(P) binding site [chemical binding]; other site
326427006193	homodimer interface [polypeptide binding]; other site
326427006194	substrate binding site [chemical binding]; other site
326427006195	active site
326427006196	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
326427006197	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
326427006198	inhibitor-cofactor binding pocket; inhibition site
326427006199	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427006200	catalytic residue [active]
326427006201	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
326427006202	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
326427006203	putative trimer interface [polypeptide binding]; other site
326427006204	putative CoA binding site [chemical binding]; other site
326427006205	Bacterial sugar transferase; Region: Bac_transf; pfam02397
326427006206	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
326427006207	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
326427006208	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
326427006209	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
326427006210	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
326427006211	replicative DNA helicase; Region: DnaB; TIGR00665
326427006212	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
326427006213	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
326427006214	Walker A motif; other site
326427006215	ATP binding site [chemical binding]; other site
326427006216	Walker B motif; other site
326427006217	DNA binding loops [nucleotide binding]
326427006218	DAK2 domain; Region: Dak2; cl03685
326427006219	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
326427006220	active pocket/dimerization site; other site
326427006221	active site
326427006222	phosphorylation site [posttranslational modification]
326427006223	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
326427006224	dimerization domain swap beta strand [polypeptide binding]; other site
326427006225	regulatory protein interface [polypeptide binding]; other site
326427006226	active site
326427006227	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
326427006228	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
326427006229	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
326427006230	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
326427006231	Calx-beta domain; Region: Calx-beta; pfam03160
326427006232	Calx-beta domain; Region: Calx-beta; cl02522
326427006233	Calx-beta domain; Region: Calx-beta; pfam03160
326427006234	Calx-beta domain; Region: Calx-beta; cl02522
326427006235	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
326427006236	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326427006237	dimerization interface [polypeptide binding]; other site
326427006238	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
326427006239	PAS domain; Region: PAS; smart00091
326427006240	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427006241	dimer interface [polypeptide binding]; other site
326427006242	phosphorylation site [posttranslational modification]
326427006243	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427006244	ATP binding site [chemical binding]; other site
326427006245	Mg2+ binding site [ion binding]; other site
326427006246	G-X-G motif; other site
326427006247	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
326427006248	putative hydrolase; Provisional; Region: PRK02113
326427006249	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
326427006250	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427006251	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
326427006252	Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: GCD2; COG1184
326427006253	Response regulator receiver domain; Region: Response_reg; pfam00072
326427006254	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427006255	active site
326427006256	phosphorylation site [posttranslational modification]
326427006257	intermolecular recognition site; other site
326427006258	dimerization interface [polypeptide binding]; other site
326427006259	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427006260	GAF domain; Region: GAF_3; pfam13492
326427006261	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427006262	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326427006263	putative active site [active]
326427006264	heme pocket [chemical binding]; other site
326427006265	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427006266	dimer interface [polypeptide binding]; other site
326427006267	phosphorylation site [posttranslational modification]
326427006268	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427006269	ATP binding site [chemical binding]; other site
326427006270	Mg2+ binding site [ion binding]; other site
326427006271	G-X-G motif; other site
326427006272	Response regulator receiver domain; Region: Response_reg; pfam00072
326427006273	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427006274	active site
326427006275	phosphorylation site [posttranslational modification]
326427006276	intermolecular recognition site; other site
326427006277	dimerization interface [polypeptide binding]; other site
326427006278	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
326427006279	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
326427006280	substrate binding site [chemical binding]; other site
326427006281	ATP binding site [chemical binding]; other site
326427006282	BtpA family; Region: BtpA; cl00440
326427006283	Bacterial SH3 domain homologues; Region: SH3b; smart00287
326427006284	Bacterial SH3 domain; Region: SH3_3; pfam08239
326427006285	Bacterial SH3 domain; Region: SH3_3; pfam08239
326427006286	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
326427006287	NlpC/P60 family; Region: NLPC_P60; pfam00877
326427006288	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427006289	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427006290	GAF domain; Region: GAF_2; pfam13185
326427006291	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427006292	GAF domain; Region: GAF_3; pfam13492
326427006293	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326427006294	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427006295	dimer interface [polypeptide binding]; other site
326427006296	phosphorylation site [posttranslational modification]
326427006297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427006298	ATP binding site [chemical binding]; other site
326427006299	Mg2+ binding site [ion binding]; other site
326427006300	G-X-G motif; other site
326427006301	Response regulator receiver domain; Region: Response_reg; pfam00072
326427006302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427006303	active site
326427006304	phosphorylation site [posttranslational modification]
326427006305	intermolecular recognition site; other site
326427006306	dimerization interface [polypeptide binding]; other site
326427006307	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
326427006308	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
326427006309	dimer interface [polypeptide binding]; other site
326427006310	ssDNA binding site [nucleotide binding]; other site
326427006311	tetramer (dimer of dimers) interface [polypeptide binding]; other site
326427006312	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
326427006313	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
326427006314	dimer interface [polypeptide binding]; other site
326427006315	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427006316	catalytic residue [active]
326427006317	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
326427006318	putative DNA binding helix; other site
326427006319	metal binding site 2 [ion binding]; metal-binding site
326427006320	metal binding site 1 [ion binding]; metal-binding site
326427006321	dimer interface [polypeptide binding]; other site
326427006322	structural Zn2+ binding site [ion binding]; other site
326427006323	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
326427006324	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326427006325	ligand binding site [chemical binding]; other site
326427006326	flexible hinge region; other site
326427006327	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
326427006328	putative switch regulator; other site
326427006329	non-specific DNA interactions [nucleotide binding]; other site
326427006330	DNA binding site [nucleotide binding]
326427006331	sequence specific DNA binding site [nucleotide binding]; other site
326427006332	putative cAMP binding site [chemical binding]; other site
326427006333	Predicted permease; Region: DUF318; cl17795
326427006334	enoyl-CoA hydratase; Validated; Region: PRK08139
326427006335	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326427006336	substrate binding site [chemical binding]; other site
326427006337	oxyanion hole (OAH) forming residues; other site
326427006338	trimer interface [polypeptide binding]; other site
326427006339	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
326427006340	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
326427006341	N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013
326427006342	tetramer interface [polypeptide binding]; other site
326427006343	catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211
326427006344	C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014
326427006345	tetramer interface [polypeptide binding]; other site
326427006346	active site
326427006347	metal binding site [ion binding]; metal-binding site
326427006348	Transcriptional regulator [Transcription]; Region: IclR; COG1414
326427006349	Bacterial transcriptional regulator; Region: IclR; pfam01614
326427006350	acetaldehyde dehydrogenase; Validated; Region: PRK08300
326427006351	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
326427006352	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
326427006353	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
326427006354	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
326427006355	active site
326427006356	catalytic residues [active]
326427006357	metal binding site [ion binding]; metal-binding site
326427006358	DmpG-like communication domain; Region: DmpG_comm; pfam07836
326427006359	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
326427006360	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
326427006361	dimer interface [polypeptide binding]; other site
326427006362	hexamer interface [polypeptide binding]; other site
326427006363	active site 2 [active]
326427006364	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
326427006365	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326427006366	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
326427006367	NAD binding site [chemical binding]; other site
326427006368	catalytic residues [active]
326427006369	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
326427006370	Predicted methyltransferases [General function prediction only]; Region: COG0313
326427006371	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
326427006372	putative SAM binding site [chemical binding]; other site
326427006373	putative homodimer interface [polypeptide binding]; other site
326427006374	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
326427006375	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
326427006376	NADP-binding site; other site
326427006377	homotetramer interface [polypeptide binding]; other site
326427006378	substrate binding site [chemical binding]; other site
326427006379	homodimer interface [polypeptide binding]; other site
326427006380	active site
326427006381	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
326427006382	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
326427006383	intersubunit interface [polypeptide binding]; other site
326427006384	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
326427006385	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
326427006386	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
326427006387	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
326427006388	dimer interface [polypeptide binding]; other site
326427006389	putative PBP binding regions; other site
326427006390	ABC-ATPase subunit  interface; other site
326427006391	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
326427006392	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
326427006393	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427006394	active site
326427006395	phosphorylation site [posttranslational modification]
326427006396	intermolecular recognition site; other site
326427006397	dimerization interface [polypeptide binding]; other site
326427006398	ANTAR domain; Region: ANTAR; pfam03861
326427006399	TMAO/DMSO reductase; Reviewed; Region: PRK05363
326427006400	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
326427006401	Moco binding site; other site
326427006402	metal coordination site [ion binding]; other site
326427006403	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
326427006404	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326427006405	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427006406	active site
326427006407	phosphorylation site [posttranslational modification]
326427006408	intermolecular recognition site; other site
326427006409	dimerization interface [polypeptide binding]; other site
326427006410	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326427006411	DNA binding site [nucleotide binding]
326427006412	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
326427006413	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
326427006414	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
326427006415	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
326427006416	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
326427006417	catalytic triad [active]
326427006418	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
326427006419	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
326427006420	ligand binding site [chemical binding]; other site
326427006421	dimerization interface [polypeptide binding]; other site
326427006422	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326427006423	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427006424	dimer interface [polypeptide binding]; other site
326427006425	phosphorylation site [posttranslational modification]
326427006426	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427006427	ATP binding site [chemical binding]; other site
326427006428	Mg2+ binding site [ion binding]; other site
326427006429	G-X-G motif; other site
326427006430	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427006431	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
326427006432	active site
326427006433	phosphorylation site [posttranslational modification]
326427006434	intermolecular recognition site; other site
326427006435	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
326427006436	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
326427006437	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
326427006438	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
326427006439	Probable zinc-binding domain; Region: zf-trcl; pfam13451
326427006440	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
326427006441	Peptidase family M50; Region: Peptidase_M50; pfam02163
326427006442	active site
326427006443	putative substrate binding region [chemical binding]; other site
326427006444	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
326427006445	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
326427006446	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
326427006447	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
326427006448	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
326427006449	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
326427006450	Probable Catalytic site; other site
326427006451	metal-binding site
326427006452	Response regulator receiver domain; Region: Response_reg; pfam00072
326427006453	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427006454	active site
326427006455	phosphorylation site [posttranslational modification]
326427006456	intermolecular recognition site; other site
326427006457	dimerization interface [polypeptide binding]; other site
326427006458	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
326427006459	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427006460	ATP binding site [chemical binding]; other site
326427006461	Mg2+ binding site [ion binding]; other site
326427006462	G-X-G motif; other site
326427006463	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427006464	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427006465	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
326427006466	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
326427006467	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
326427006468	anti sigma factor interaction site; other site
326427006469	regulatory phosphorylation site [posttranslational modification]; other site
326427006470	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
326427006471	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
326427006472	active site
326427006473	Substrate binding site; other site
326427006474	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208
326427006475	putative trimer interface [polypeptide binding]; other site
326427006476	putative CoA binding site [chemical binding]; other site
326427006477	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
326427006478	putative trimer interface [polypeptide binding]; other site
326427006479	putative CoA binding site [chemical binding]; other site
326427006480	Bacterial sugar transferase; Region: Bac_transf; cl00939
326427006481	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
326427006482	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
326427006483	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
326427006484	anti sigma factor interaction site; other site
326427006485	regulatory phosphorylation site [posttranslational modification]; other site
326427006486	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
326427006487	anti sigma factor interaction site; other site
326427006488	regulatory phosphorylation site [posttranslational modification]; other site
326427006489	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
326427006490	Bacterial sugar transferase; Region: Bac_transf; pfam02397
326427006491	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
326427006492	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
326427006493	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
326427006494	trimer interface [polypeptide binding]; other site
326427006495	active site
326427006496	substrate binding site [chemical binding]; other site
326427006497	CoA binding site [chemical binding]; other site
326427006498	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
326427006499	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
326427006500	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
326427006501	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
326427006502	DXD motif; other site
326427006503	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427006504	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427006505	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427006506	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427006507	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
326427006508	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
326427006509	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
326427006510	NADP-binding site; other site
326427006511	homotetramer interface [polypeptide binding]; other site
326427006512	substrate binding site [chemical binding]; other site
326427006513	homodimer interface [polypeptide binding]; other site
326427006514	active site
326427006515	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
326427006516	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
326427006517	CoA-ligase; Region: Ligase_CoA; pfam00549
326427006518	DNA adenine methylase (dam); Region: dam; TIGR00571
326427006519	Uncharacterized conserved protein [Function unknown]; Region: COG3375
326427006520	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
326427006521	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
326427006522	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
326427006523	active site
326427006524	homodimer interface [polypeptide binding]; other site
326427006525	catalytic site [active]
326427006526	acceptor binding site [chemical binding]; other site
326427006527	trehalose synthase; Region: treS_nterm; TIGR02456
326427006528	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
326427006529	active site
326427006530	catalytic site [active]
326427006531	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
326427006532	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
326427006533	glycogen branching enzyme; Provisional; Region: PRK12313
326427006534	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
326427006535	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
326427006536	active site
326427006537	catalytic site [active]
326427006538	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
326427006539	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
326427006540	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
326427006541	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
326427006542	catalytic site [active]
326427006543	active site
326427006544	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
326427006545	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
326427006546	active site
326427006547	catalytic site [active]
326427006548	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
326427006549	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
326427006550	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
326427006551	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
326427006552	active site
326427006553	catalytic site [active]
326427006554	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
326427006555	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
326427006556	tetramer interface [polypeptide binding]; other site
326427006557	TPP-binding site [chemical binding]; other site
326427006558	heterodimer interface [polypeptide binding]; other site
326427006559	phosphorylation loop region [posttranslational modification]
326427006560	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
326427006561	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
326427006562	alpha subunit interface [polypeptide binding]; other site
326427006563	TPP binding site [chemical binding]; other site
326427006564	heterodimer interface [polypeptide binding]; other site
326427006565	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
326427006566	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
326427006567	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
326427006568	E3 interaction surface; other site
326427006569	lipoyl attachment site [posttranslational modification]; other site
326427006570	e3 binding domain; Region: E3_binding; pfam02817
326427006571	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
326427006572	CHAT domain; Region: CHAT; cl17868
326427006573	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326427006574	kynureninase; Region: kynureninase; TIGR01814
326427006575	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326427006576	catalytic residue [active]
326427006577	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427006578	S-adenosylmethionine binding site [chemical binding]; other site
326427006579	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
326427006580	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326427006581	ligand binding site [chemical binding]; other site
326427006582	flexible hinge region; other site
326427006583	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
326427006584	putative switch regulator; other site
326427006585	non-specific DNA interactions [nucleotide binding]; other site
326427006586	DNA binding site [nucleotide binding]
326427006587	sequence specific DNA binding site [nucleotide binding]; other site
326427006588	putative cAMP binding site [chemical binding]; other site
326427006589	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
326427006590	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
326427006591	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
326427006592	Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662
326427006593	Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060
326427006594	Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662
326427006595	Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060
326427006596	Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662
326427006597	Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060
326427006598	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427006599	TPR motif; other site
326427006600	Tetratricopeptide repeat; Region: TPR_16; pfam13432
326427006601	binding surface
326427006602	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427006603	TPR motif; other site
326427006604	binding surface
326427006605	TPR repeat; Region: TPR_11; pfam13414
326427006606	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
326427006607	dimer interface [polypeptide binding]; other site
326427006608	[2Fe-2S] cluster binding site [ion binding]; other site
326427006609	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
326427006610	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
326427006611	TPP-binding site [chemical binding]; other site
326427006612	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
326427006613	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
326427006614	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
326427006615	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
326427006616	dimer interface [polypeptide binding]; other site
326427006617	PYR/PP interface [polypeptide binding]; other site
326427006618	TPP binding site [chemical binding]; other site
326427006619	substrate binding site [chemical binding]; other site
326427006620	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
326427006621	AAA domain; Region: AAA_30; pfam13604
326427006622	AAA domain; Region: AAA_12; pfam13087
326427006623	YcxB-like protein; Region: YcxB; pfam14317
326427006624	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
326427006625	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326427006626	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
326427006627	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
326427006628	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
326427006629	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
326427006630	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
326427006631	Sulfate transporter family; Region: Sulfate_transp; pfam00916
326427006632	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
326427006633	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
326427006634	active site residue [active]
326427006635	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
326427006636	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
326427006637	Sulfate transporter family; Region: Sulfate_transp; pfam00916
326427006638	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
326427006639	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
326427006640	active site residue [active]
326427006641	fructose 1,6-bisphosphatase II; Reviewed; Region: glpX; PRK09479
326427006642	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
326427006643	active site
326427006644	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
326427006645	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
326427006646	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
326427006647	DNA binding site [nucleotide binding]
326427006648	active site
326427006649	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
326427006650	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
326427006651	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
326427006652	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
326427006653	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
326427006654	active site
326427006655	HIGH motif; other site
326427006656	dimer interface [polypeptide binding]; other site
326427006657	KMSKS motif; other site
326427006658	Protein of unknown function, DUF608; Region: DUF608; pfam04685
326427006659	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
326427006660	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
326427006661	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427006662	catalytic residue [active]
326427006663	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
326427006664	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
326427006665	phytoene desaturase; Region: crtI_fam; TIGR02734
326427006666	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
326427006667	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
326427006668	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
326427006669	CAAX protease self-immunity; Region: Abi; pfam02517
326427006670	Predicted membrane protein [Function unknown]; Region: COG3174
326427006671	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
326427006672	Phospholipid methyltransferase; Region: PEMT; cl17370
326427006673	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14604
326427006674	RuvA N terminal domain; Region: RuvA_N; pfam01330
326427006675	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
326427006676	active site
326427006677	Bifunctional nuclease; Region: DNase-RNase; pfam02577
326427006678	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
326427006679	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
326427006680	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
326427006681	Bacterial SH3 domain; Region: SH3_3; pfam08239
326427006682	Peptidase family M23; Region: Peptidase_M23; pfam01551
326427006683	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
326427006684	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326427006685	P-loop; other site
326427006686	Magnesium ion binding site [ion binding]; other site
326427006687	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
326427006688	Magnesium ion binding site [ion binding]; other site
326427006689	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
326427006690	ParB-like nuclease domain; Region: ParBc; pfam02195
326427006691	KorB domain; Region: KorB; pfam08535
326427006692	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
326427006693	Ribokinase-like subgroup D.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_D; cd01937
326427006694	substrate binding site [chemical binding]; other site
326427006695	ATP binding site [chemical binding]; other site
326427006696	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
326427006697	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
326427006698	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
326427006699	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
326427006700	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
326427006701	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
326427006702	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
326427006703	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
326427006704	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
326427006705	extended (e) SDRs; Region: SDR_e; cd08946
326427006706	NAD(P) binding site [chemical binding]; other site
326427006707	active site
326427006708	substrate binding site [chemical binding]; other site
326427006709	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
326427006710	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
326427006711	substrate binding site; other site
326427006712	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
326427006713	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
326427006714	NAD binding site [chemical binding]; other site
326427006715	putative substrate binding site 2 [chemical binding]; other site
326427006716	putative substrate binding site 1 [chemical binding]; other site
326427006717	active site
326427006718	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
326427006719	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427006720	NAD(P) binding site [chemical binding]; other site
326427006721	active site
326427006722	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
326427006723	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
326427006724	inhibitor-cofactor binding pocket; inhibition site
326427006725	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427006726	catalytic residue [active]
326427006727	Flp/Fap pilin component; Region: Flp_Fap; cl01585
326427006728	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
326427006729	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326427006730	ligand binding site [chemical binding]; other site
326427006731	flexible hinge region; other site
326427006732	non-specific DNA interactions [nucleotide binding]; other site
326427006733	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
326427006734	DNA binding site [nucleotide binding]
326427006735	sequence specific DNA binding site [nucleotide binding]; other site
326427006736	putative cAMP binding site [chemical binding]; other site
326427006737	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326427006738	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
326427006739	catalytic site [active]
326427006740	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
326427006741	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
326427006742	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
326427006743	active site
326427006744	catalytic site [active]
326427006745	substrate binding site [chemical binding]; other site
326427006746	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
326427006747	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
326427006748	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326427006749	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
326427006750	catalytic site [active]
326427006751	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427006752	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
326427006753	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
326427006754	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
326427006755	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
326427006756	nudix motif; other site
326427006757	trigger factor; Region: tig; TIGR00115
326427006758	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
326427006759	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
326427006760	Clp protease; Region: CLP_protease; pfam00574
326427006761	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
326427006762	oligomer interface [polypeptide binding]; other site
326427006763	active site residues [active]
326427006764	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
326427006765	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
326427006766	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427006767	Walker A motif; other site
326427006768	ATP binding site [chemical binding]; other site
326427006769	Walker B motif; other site
326427006770	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
326427006771	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326427006772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427006773	active site
326427006774	phosphorylation site [posttranslational modification]
326427006775	intermolecular recognition site; other site
326427006776	dimerization interface [polypeptide binding]; other site
326427006777	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326427006778	DNA binding site [nucleotide binding]
326427006779	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
326427006780	active site
326427006781	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
326427006782	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
326427006783	Mg++ binding site [ion binding]; other site
326427006784	putative catalytic motif [active]
326427006785	substrate binding site [chemical binding]; other site
326427006786	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
326427006787	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
326427006788	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
326427006789	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
326427006790	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326427006791	motif II; other site
326427006792	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
326427006793	Cobalt transport protein; Region: CbiQ; cl00463
326427006794	cobalamin synthase; Reviewed; Region: cobS; PRK00235
326427006795	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
326427006796	catalytic core [active]
326427006797	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
326427006798	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
326427006799	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
326427006800	acetyl-lysine deacetylase; Provisional; Region: PRK04443
326427006801	M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653
326427006802	metal binding site [ion binding]; metal-binding site
326427006803	putative dimer interface [polypeptide binding]; other site
326427006804	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
326427006805	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
326427006806	Probable transposase; Region: OrfB_IS605; pfam01385
326427006807	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
326427006808	Transposase IS200 like; Region: Y1_Tnp; pfam01797
326427006809	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
326427006810	Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Ade5; cd01416
326427006811	ATP binding site [chemical binding]; other site
326427006812	active site
326427006813	substrate binding site [chemical binding]; other site
326427006814	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
326427006815	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
326427006816	dimerization interface [polypeptide binding]; other site
326427006817	putative ATP binding site [chemical binding]; other site
326427006818	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
326427006819	ATP phosphoribosyltransferase; Region: HisG; cl15266
326427006820	HisG, C-terminal domain; Region: HisG_C; cl06867
326427006821	Creatinine amidohydrolase; Region: Creatininase; cl00618
326427006822	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
326427006823	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
326427006824	dimer interface [polypeptide binding]; other site
326427006825	motif 1; other site
326427006826	motif 2; other site
326427006827	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
326427006828	motif 3; other site
326427006829	Response regulator receiver domain; Region: Response_reg; pfam00072
326427006830	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427006831	active site
326427006832	phosphorylation site [posttranslational modification]
326427006833	intermolecular recognition site; other site
326427006834	dimerization interface [polypeptide binding]; other site
326427006835	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326427006836	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427006837	dimer interface [polypeptide binding]; other site
326427006838	phosphorylation site [posttranslational modification]
326427006839	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427006840	ATP binding site [chemical binding]; other site
326427006841	Mg2+ binding site [ion binding]; other site
326427006842	G-X-G motif; other site
326427006843	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
326427006844	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
326427006845	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
326427006846	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
326427006847	metal ion-dependent adhesion site (MIDAS); other site
326427006848	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
326427006849	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
326427006850	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
326427006851	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427006852	dimer interface [polypeptide binding]; other site
326427006853	putative PBP binding loops; other site
326427006854	ABC-ATPase subunit interface; other site
326427006855	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
326427006856	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427006857	dimer interface [polypeptide binding]; other site
326427006858	conserved gate region; other site
326427006859	putative PBP binding loops; other site
326427006860	ABC-ATPase subunit interface; other site
326427006861	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
326427006862	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
326427006863	Domain of unknown function (DUF333); Region: DUF333; pfam03891
326427006864	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
326427006865	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
326427006866	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
326427006867	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
326427006868	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
326427006869	TRAM domain; Region: TRAM; pfam01938
326427006870	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427006871	S-adenosylmethionine binding site [chemical binding]; other site
326427006872	Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154
326427006873	Rab subfamily motif 1 (RabSF1); other site
326427006874	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
326427006875	G1 box; other site
326427006876	GTP/Mg2+ binding site [chemical binding]; other site
326427006877	Rab subfamily motif 2 (RabSF2); other site
326427006878	Switch I region; other site
326427006879	G2 box; other site
326427006880	effector interaction site; other site
326427006881	GDI interaction site; other site
326427006882	Rab family motif 1 (RabF1); other site
326427006883	GEF interaction site [polypeptide binding]; other site
326427006884	Rab family motif 2 (RabF2); other site
326427006885	G3 box; other site
326427006886	Switch II region; other site
326427006887	Rab family motif 3 (RabF3); other site
326427006888	Rab family motif 4 (RabF4); other site
326427006889	Rab family motif 5 (RabF5); other site
326427006890	Rab subfamily motif 3 (RabSF3); other site
326427006891	G4 box; other site
326427006892	G5 box; other site
326427006893	Rab subfamily motif 4 (RabSF4); other site
326427006894	PAS fold; Region: PAS_4; pfam08448
326427006895	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326427006896	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427006897	dimer interface [polypeptide binding]; other site
326427006898	phosphorylation site [posttranslational modification]
326427006899	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427006900	ATP binding site [chemical binding]; other site
326427006901	Mg2+ binding site [ion binding]; other site
326427006902	G-X-G motif; other site
326427006903	Response regulator receiver domain; Region: Response_reg; pfam00072
326427006904	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427006905	active site
326427006906	phosphorylation site [posttranslational modification]
326427006907	intermolecular recognition site; other site
326427006908	dimerization interface [polypeptide binding]; other site
326427006909	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
326427006910	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
326427006911	metal-binding site
326427006912	SpoVR like protein; Region: SpoVR; pfam04293
326427006913	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
326427006914	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
326427006915	protein-splicing catalytic site; other site
326427006916	thioester formation/cholesterol transfer; other site
326427006917	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
326427006918	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
326427006919	hypothetical protein; Provisional; Region: PRK05325
326427006920	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
326427006921	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
326427006922	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
326427006923	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427006924	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427006925	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
326427006926	Dynamin family; Region: Dynamin_N; pfam00350
326427006927	G1 box; other site
326427006928	GTP/Mg2+ binding site [chemical binding]; other site
326427006929	G2 box; other site
326427006930	Switch I region; other site
326427006931	G3 box; other site
326427006932	Switch II region; other site
326427006933	G4 box; other site
326427006934	G5 box; other site
326427006935	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
326427006936	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427006937	active site
326427006938	phosphorylation site [posttranslational modification]
326427006939	intermolecular recognition site; other site
326427006940	dimerization interface [polypeptide binding]; other site
326427006941	GAF domain; Region: GAF_2; pfam13185
326427006942	GAF domain; Region: GAF_3; pfam13492
326427006943	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427006944	dimer interface [polypeptide binding]; other site
326427006945	phosphorylation site [posttranslational modification]
326427006946	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427006947	ATP binding site [chemical binding]; other site
326427006948	Mg2+ binding site [ion binding]; other site
326427006949	G-X-G motif; other site
326427006950	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326427006951	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427006952	active site
326427006953	phosphorylation site [posttranslational modification]
326427006954	intermolecular recognition site; other site
326427006955	dimerization interface [polypeptide binding]; other site
326427006956	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326427006957	DNA binding site [nucleotide binding]
326427006958	Fe-S metabolism associated domain; Region: SufE; cl00951
326427006959	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326427006960	NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078
326427006961	NAD(P) binding site [chemical binding]; other site
326427006962	catalytic residues [active]
326427006963	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
326427006964	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
326427006965	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
326427006966	metal binding site [ion binding]; metal-binding site
326427006967	dimer interface [polypeptide binding]; other site
326427006968	PAS domain S-box; Region: sensory_box; TIGR00229
326427006969	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427006970	putative active site [active]
326427006971	heme pocket [chemical binding]; other site
326427006972	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427006973	PAS fold; Region: PAS_3; pfam08447
326427006974	putative active site [active]
326427006975	heme pocket [chemical binding]; other site
326427006976	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427006977	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
326427006978	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
326427006979	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326427006980	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326427006981	DNA binding residues [nucleotide binding]
326427006982	RibD C-terminal domain; Region: RibD_C; cl17279
326427006983	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
326427006984	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
326427006985	FOG: CBS domain [General function prediction only]; Region: COG0517
326427006986	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
326427006987	Methyltransferase domain; Region: Methyltransf_23; pfam13489
326427006988	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427006989	S-adenosylmethionine binding site [chemical binding]; other site
326427006990	Methyltransferase domain; Region: Methyltransf_23; pfam13489
326427006991	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427006992	S-adenosylmethionine binding site [chemical binding]; other site
326427006993	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
326427006994	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
326427006995	glycogen synthase; Provisional; Region: PRK14099
326427006996	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427006997	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
326427006998	DNA methylase; Region: N6_N4_Mtase; pfam01555
326427006999	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
326427007000	DNA methylase; Region: N6_N4_Mtase; pfam01555
326427007001	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427007002	S-adenosylmethionine binding site [chemical binding]; other site
326427007003	Restriction endonuclease NotI; Region: NotI; pfam12183
326427007004	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
326427007005	DNA methylase; Region: N6_N4_Mtase; pfam01555
326427007006	Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195
326427007007	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
326427007008	active site
326427007009	cosubstrate binding site; other site
326427007010	substrate binding site [chemical binding]; other site
326427007011	catalytic site [active]
326427007012	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
326427007013	phosphopeptide binding site; other site
326427007014	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
326427007015	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
326427007016	active site
326427007017	cosubstrate binding site; other site
326427007018	substrate binding site [chemical binding]; other site
326427007019	catalytic site [active]
326427007020	oxidative damage protection protein; Provisional; Region: PRK05408
326427007021	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
326427007022	Methyltransferase domain; Region: Methyltransf_26; pfam13659
326427007023	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326427007024	FeS/SAM binding site; other site
326427007025	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
326427007026	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
326427007027	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
326427007028	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
326427007029	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
326427007030	Uncharacterized conserved protein [Function unknown]; Region: COG2308
326427007031	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
326427007032	Fatty acid desaturase; Region: FA_desaturase; pfam00487
326427007033	Di-iron ligands [ion binding]; other site
326427007034	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
326427007035	C-terminal peptidase (prc); Region: prc; TIGR00225
326427007036	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
326427007037	protein binding site [polypeptide binding]; other site
326427007038	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
326427007039	Catalytic dyad [active]
326427007040	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
326427007041	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
326427007042	oligomer interface [polypeptide binding]; other site
326427007043	active site
326427007044	metal binding site [ion binding]; metal-binding site
326427007045	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
326427007046	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
326427007047	active site
326427007048	NTP binding site [chemical binding]; other site
326427007049	metal binding triad [ion binding]; metal-binding site
326427007050	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
326427007051	Lamin Tail Domain; Region: LTD; pfam00932
326427007052	CAAX protease self-immunity; Region: Abi; pfam02517
326427007053	beta-phosphoglucomutase; Region: bPGM; TIGR01990
326427007054	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326427007055	motif II; other site
326427007056	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
326427007057	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
326427007058	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
326427007059	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
326427007060	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427007061	dimer interface [polypeptide binding]; other site
326427007062	conserved gate region; other site
326427007063	putative PBP binding loops; other site
326427007064	ABC-ATPase subunit interface; other site
326427007065	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427007066	dimer interface [polypeptide binding]; other site
326427007067	conserved gate region; other site
326427007068	putative PBP binding loops; other site
326427007069	ABC-ATPase subunit interface; other site
326427007070	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
326427007071	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
326427007072	Transcriptional regulators [Transcription]; Region: PurR; COG1609
326427007073	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
326427007074	DNA binding site [nucleotide binding]
326427007075	domain linker motif; other site
326427007076	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
326427007077	ligand binding site [chemical binding]; other site
326427007078	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326427007079	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
326427007080	ligand binding site [chemical binding]; other site
326427007081	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
326427007082	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326427007083	ligand binding site [chemical binding]; other site
326427007084	flexible hinge region; other site
326427007085	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
326427007086	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
326427007087	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
326427007088	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
326427007089	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
326427007090	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
326427007091	gamma-glutamyl kinase; Provisional; Region: PRK05429
326427007092	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
326427007093	nucleotide binding site [chemical binding]; other site
326427007094	homotetrameric interface [polypeptide binding]; other site
326427007095	putative phosphate binding site [ion binding]; other site
326427007096	putative allosteric binding site; other site
326427007097	PUA domain; Region: PUA; pfam01472
326427007098	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
326427007099	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
326427007100	HIGH motif; other site
326427007101	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
326427007102	active site
326427007103	KMSKS motif; other site
326427007104	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
326427007105	homodimer interface [polypeptide binding]; other site
326427007106	maltodextrin glucosidase; Provisional; Region: PRK10785
326427007107	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
326427007108	active site
326427007109	homodimer interface [polypeptide binding]; other site
326427007110	catalytic site [active]
326427007111	CAAX protease self-immunity; Region: Abi; pfam02517
326427007112	cell division protein MraZ; Reviewed; Region: PRK00326
326427007113	MraZ protein; Region: MraZ; pfam02381
326427007114	MraZ protein; Region: MraZ; pfam02381
326427007115	CHAT domain; Region: CHAT; pfam12770
326427007116	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
326427007117	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
326427007118	amidase catalytic site [active]
326427007119	Zn binding residues [ion binding]; other site
326427007120	substrate binding site [chemical binding]; other site
326427007121	cell division protein FtsZ; Region: ftsZ; TIGR00065
326427007122	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
326427007123	nucleotide binding site [chemical binding]; other site
326427007124	SulA interaction site; other site
326427007125	Restriction endonuclease; Region: Mrr_cat; pfam04471
326427007126	Bacterial SH3 domain homologues; Region: SH3b; smart00287
326427007127	lipoprotein signal peptidase; Provisional; Region: PRK14790
326427007128	lipoprotein signal peptidase; Provisional; Region: PRK14787
326427007129	lipoprotein signal peptidase; Provisional; Region: PRK14789
326427007130	lipoprotein signal peptidase; Provisional; Region: PRK14787
326427007131	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
326427007132	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
326427007133	RNA binding surface [nucleotide binding]; other site
326427007134	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
326427007135	active site
326427007136	malate dehydrogenase, NAD-dependent; Region: MalateDH_bact; TIGR01763
326427007137	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
326427007138	NAD(P) binding site [chemical binding]; other site
326427007139	dimer interface [polypeptide binding]; other site
326427007140	tetramer (dimer of dimers) interface [polypeptide binding]; other site
326427007141	substrate binding site [chemical binding]; other site
326427007142	GAF domain; Region: GAF_3; pfam13492
326427007143	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326427007144	Histidine kinase; Region: HisKA_3; pfam07730
326427007145	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427007146	ATP binding site [chemical binding]; other site
326427007147	Mg2+ binding site [ion binding]; other site
326427007148	G-X-G motif; other site
326427007149	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
326427007150	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
326427007151	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
326427007152	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
326427007153	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
326427007154	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
326427007155	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
326427007156	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
326427007157	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
326427007158	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
326427007159	30S subunit binding site; other site
326427007160	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
326427007161	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
326427007162	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
326427007163	active site
326427007164	ribulose/triose binding site [chemical binding]; other site
326427007165	phosphate binding site [ion binding]; other site
326427007166	substrate (anthranilate) binding pocket [chemical binding]; other site
326427007167	product (indole) binding pocket [chemical binding]; other site
326427007168	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
326427007169	Methyltransferase domain; Region: Methyltransf_23; pfam13489
326427007170	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427007171	S-adenosylmethionine binding site [chemical binding]; other site
326427007172	hypothetical protein; Provisional; Region: PRK07208
326427007173	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
326427007174	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
326427007175	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
326427007176	Probable Catalytic site; other site
326427007177	metal-binding site
326427007178	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
326427007179	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
326427007180	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427007181	Walker A motif; other site
326427007182	ATP binding site [chemical binding]; other site
326427007183	Walker B motif; other site
326427007184	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
326427007185	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
326427007186	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326427007187	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326427007188	DNA binding residues [nucleotide binding]
326427007189	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
326427007190	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326427007191	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
326427007192	DNA binding residues [nucleotide binding]
326427007193	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
326427007194	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326427007195	DNA binding residues [nucleotide binding]
326427007196	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
326427007197	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326427007198	DNA binding residues [nucleotide binding]
326427007199	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
326427007200	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
326427007201	DNA binding residues [nucleotide binding]
326427007202	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
326427007203	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326427007204	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
326427007205	DNA binding residues [nucleotide binding]
326427007206	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
326427007207	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326427007208	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
326427007209	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
326427007210	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326427007211	DNA binding residues [nucleotide binding]
326427007212	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
326427007213	Protein of unknown function (DUF1626); Region: DUF1626; pfam07788
326427007214	magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030
326427007215	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427007216	Walker A motif; other site
326427007217	ATP binding site [chemical binding]; other site
326427007218	Walker B motif; other site
326427007219	arginine finger; other site
326427007220	Protein of unknown function (DUF503); Region: DUF503; pfam04456
326427007221	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
326427007222	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
326427007223	heterotetramer interface [polypeptide binding]; other site
326427007224	active site pocket [active]
326427007225	cleavage site
326427007226	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
326427007227	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
326427007228	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
326427007229	putative RNA binding site [nucleotide binding]; other site
326427007230	Methyltransferase domain; Region: Methyltransf_26; pfam13659
326427007231	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
326427007232	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
326427007233	active site
326427007234	catalytic tetrad [active]
326427007235	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
326427007236	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
326427007237	tetramer interface [polypeptide binding]; other site
326427007238	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427007239	catalytic residue [active]
326427007240	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
326427007241	GTPase RsgA; Reviewed; Region: PRK00098
326427007242	RNA binding site [nucleotide binding]; other site
326427007243	homodimer interface [polypeptide binding]; other site
326427007244	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
326427007245	GTPase/Zn-binding domain interface [polypeptide binding]; other site
326427007246	GTP/Mg2+ binding site [chemical binding]; other site
326427007247	G4 box; other site
326427007248	G5 box; other site
326427007249	G1 box; other site
326427007250	Switch I region; other site
326427007251	G2 box; other site
326427007252	G3 box; other site
326427007253	Switch II region; other site
326427007254	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
326427007255	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
326427007256	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427007257	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427007258	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
326427007259	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
326427007260	catalytic residues [active]
326427007261	DNA gyrase subunit A; Validated; Region: PRK05560
326427007262	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
326427007263	CAP-like domain; other site
326427007264	active site
326427007265	primary dimer interface [polypeptide binding]; other site
326427007266	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
326427007267	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
326427007268	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
326427007269	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
326427007270	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
326427007271	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
326427007272	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
326427007273	DNA methylase; Region: N6_N4_Mtase; pfam01555
326427007274	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
326427007275	YbbR-like protein; Region: YbbR; pfam07949
326427007276	Uncharacterized conserved protein [Function unknown]; Region: COG1624
326427007277	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
326427007278	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427007279	binding surface
326427007280	TPR motif; other site
326427007281	TPR repeat; Region: TPR_11; pfam13414
326427007282	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427007283	binding surface
326427007284	TPR motif; other site
326427007285	TPR repeat; Region: TPR_11; pfam13414
326427007286	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427007287	binding surface
326427007288	TPR motif; other site
326427007289	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427007290	binding surface
326427007291	TPR motif; other site
326427007292	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
326427007293	binding surface
326427007294	TPR motif; other site
326427007295	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427007296	binding surface
326427007297	TPR motif; other site
326427007298	ornithine carbamoyltransferase; Provisional; Region: PRK00779
326427007299	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
326427007300	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
326427007301	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427007302	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
326427007303	Walker A motif; other site
326427007304	ATP binding site [chemical binding]; other site
326427007305	Walker B motif; other site
326427007306	arginine finger; other site
326427007307	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
326427007308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427007309	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326427007310	putative substrate translocation pore; other site
326427007311	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
326427007312	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
326427007313	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
326427007314	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
326427007315	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
326427007316	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
326427007317	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
326427007318	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
326427007319	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
326427007320	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
326427007321	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
326427007322	V4R domain; Region: V4R; cl15268
326427007323	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
326427007324	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
326427007325	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
326427007326	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427007327	dimer interface [polypeptide binding]; other site
326427007328	conserved gate region; other site
326427007329	putative PBP binding loops; other site
326427007330	ABC-ATPase subunit interface; other site
326427007331	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427007332	dimer interface [polypeptide binding]; other site
326427007333	conserved gate region; other site
326427007334	putative PBP binding loops; other site
326427007335	ABC-ATPase subunit interface; other site
326427007336	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
326427007337	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
326427007338	Walker A/P-loop; other site
326427007339	ATP binding site [chemical binding]; other site
326427007340	Q-loop/lid; other site
326427007341	ABC transporter signature motif; other site
326427007342	Walker B; other site
326427007343	D-loop; other site
326427007344	H-loop/switch region; other site
326427007345	TOBE domain; Region: TOBE_2; pfam08402
326427007346	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
326427007347	Metallopeptidase family M24; Region: Peptidase_M24; pfam00557
326427007348	active site
326427007349	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
326427007350	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
326427007351	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
326427007352	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
326427007353	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
326427007354	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
326427007355	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
326427007356	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
326427007357	dimer interface [polypeptide binding]; other site
326427007358	putative anticodon binding site; other site
326427007359	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
326427007360	motif 1; other site
326427007361	active site
326427007362	motif 2; other site
326427007363	motif 3; other site
326427007364	Fic/DOC family; Region: Fic; cl00960
326427007365	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
326427007366	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427007367	NAD(P) binding site [chemical binding]; other site
326427007368	active site
326427007369	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
326427007370	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
326427007371	putative acyl-acceptor binding pocket; other site
326427007372	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326427007373	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427007374	active site
326427007375	phosphorylation site [posttranslational modification]
326427007376	intermolecular recognition site; other site
326427007377	dimerization interface [polypeptide binding]; other site
326427007378	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326427007379	DNA binding residues [nucleotide binding]
326427007380	dimerization interface [polypeptide binding]; other site
326427007381	Maf-like protein; Region: Maf; pfam02545
326427007382	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
326427007383	active site
326427007384	dimer interface [polypeptide binding]; other site
326427007385	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
326427007386	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
326427007387	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
326427007388	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
326427007389	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427007390	dimer interface [polypeptide binding]; other site
326427007391	conserved gate region; other site
326427007392	putative PBP binding loops; other site
326427007393	ABC-ATPase subunit interface; other site
326427007394	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
326427007395	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427007396	dimer interface [polypeptide binding]; other site
326427007397	conserved gate region; other site
326427007398	putative PBP binding loops; other site
326427007399	ABC-ATPase subunit interface; other site
326427007400	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
326427007401	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
326427007402	Walker A/P-loop; other site
326427007403	ATP binding site [chemical binding]; other site
326427007404	Q-loop/lid; other site
326427007405	ABC transporter signature motif; other site
326427007406	Walker B; other site
326427007407	D-loop; other site
326427007408	H-loop/switch region; other site
326427007409	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
326427007410	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
326427007411	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
326427007412	Walker A/P-loop; other site
326427007413	ATP binding site [chemical binding]; other site
326427007414	Q-loop/lid; other site
326427007415	ABC transporter signature motif; other site
326427007416	Walker B; other site
326427007417	D-loop; other site
326427007418	H-loop/switch region; other site
326427007419	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
326427007420	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
326427007421	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
326427007422	active site
326427007423	metal binding site [ion binding]; metal-binding site
326427007424	DNA binding site [nucleotide binding]
326427007425	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
326427007426	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
326427007427	active site
326427007428	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
326427007429	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
326427007430	trimer interface [polypeptide binding]; other site
326427007431	active site
326427007432	substrate binding site [chemical binding]; other site
326427007433	CoA binding site [chemical binding]; other site
326427007434	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
326427007435	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326427007436	active site
326427007437	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
326427007438	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
326427007439	trimer interface [polypeptide binding]; other site
326427007440	active site
326427007441	substrate binding site [chemical binding]; other site
326427007442	CoA binding site [chemical binding]; other site
326427007443	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427007444	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427007445	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
326427007446	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
326427007447	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
326427007448	Predicted acyl esterases [General function prediction only]; Region: COG2936
326427007449	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
326427007450	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
326427007451	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
326427007452	active site
326427007453	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
326427007454	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
326427007455	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427007456	dimer interface [polypeptide binding]; other site
326427007457	conserved gate region; other site
326427007458	putative PBP binding loops; other site
326427007459	ABC-ATPase subunit interface; other site
326427007460	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
326427007461	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427007462	dimer interface [polypeptide binding]; other site
326427007463	conserved gate region; other site
326427007464	putative PBP binding loops; other site
326427007465	ABC-ATPase subunit interface; other site
326427007466	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
326427007467	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
326427007468	peptide binding site [polypeptide binding]; other site
326427007469	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
326427007470	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
326427007471	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
326427007472	dimer interface [polypeptide binding]; other site
326427007473	ssDNA binding site [nucleotide binding]; other site
326427007474	tetramer (dimer of dimers) interface [polypeptide binding]; other site
326427007475	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
326427007476	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
326427007477	Ligand binding site; other site
326427007478	metal-binding site
326427007479	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
326427007480	Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562
326427007481	Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635
326427007482	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
326427007483	Response regulator receiver domain; Region: Response_reg; pfam00072
326427007484	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427007485	active site
326427007486	phosphorylation site [posttranslational modification]
326427007487	intermolecular recognition site; other site
326427007488	dimerization interface [polypeptide binding]; other site
326427007489	GAF domain; Region: GAF_2; pfam13185
326427007490	GAF domain; Region: GAF_3; pfam13492
326427007491	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
326427007492	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
326427007493	Zn2+ binding site [ion binding]; other site
326427007494	Mg2+ binding site [ion binding]; other site
326427007495	Response regulator receiver domain; Region: Response_reg; pfam00072
326427007496	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427007497	active site
326427007498	phosphorylation site [posttranslational modification]
326427007499	intermolecular recognition site; other site
326427007500	dimerization interface [polypeptide binding]; other site
326427007501	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
326427007502	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
326427007503	dimer interface [polypeptide binding]; other site
326427007504	NAD binding site [chemical binding]; other site
326427007505	substrate binding site [chemical binding]; other site
326427007506	tetramer (dimer of dimers) interface [polypeptide binding]; other site
326427007507	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
326427007508	anti sigma factor interaction site; other site
326427007509	regulatory phosphorylation site [posttranslational modification]; other site
326427007510	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
326427007511	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427007512	ATP binding site [chemical binding]; other site
326427007513	Mg2+ binding site [ion binding]; other site
326427007514	G-X-G motif; other site
326427007515	TPR repeat; Region: TPR_11; pfam13414
326427007516	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427007517	binding surface
326427007518	TPR motif; other site
326427007519	TPR repeat; Region: TPR_11; pfam13414
326427007520	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427007521	binding surface
326427007522	TPR motif; other site
326427007523	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427007524	binding surface
326427007525	TPR motif; other site
326427007526	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427007527	binding surface
326427007528	TPR repeat; Region: TPR_11; pfam13414
326427007529	TPR motif; other site
326427007530	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427007531	binding surface
326427007532	Tetratricopeptide repeat; Region: TPR_16; pfam13432
326427007533	TPR motif; other site
326427007534	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
326427007535	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
326427007536	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
326427007537	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
326427007538	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427007539	TPR motif; other site
326427007540	binding surface
326427007541	TPR repeat; Region: TPR_11; pfam13414
326427007542	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
326427007543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427007544	active site
326427007545	phosphorylation site [posttranslational modification]
326427007546	intermolecular recognition site; other site
326427007547	dimerization interface [polypeptide binding]; other site
326427007548	CheB methylesterase; Region: CheB_methylest; pfam01339
326427007549	Response regulator receiver domain; Region: Response_reg; pfam00072
326427007550	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427007551	active site
326427007552	phosphorylation site [posttranslational modification]
326427007553	intermolecular recognition site; other site
326427007554	dimerization interface [polypeptide binding]; other site
326427007555	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
326427007556	putative binding surface; other site
326427007557	active site
326427007558	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
326427007559	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427007560	ATP binding site [chemical binding]; other site
326427007561	Mg2+ binding site [ion binding]; other site
326427007562	G-X-G motif; other site
326427007563	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
326427007564	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
326427007565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427007566	active site
326427007567	phosphorylation site [posttranslational modification]
326427007568	intermolecular recognition site; other site
326427007569	dimerization interface [polypeptide binding]; other site
326427007570	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
326427007571	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
326427007572	dimer interface [polypeptide binding]; other site
326427007573	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
326427007574	putative CheW interface [polypeptide binding]; other site
326427007575	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
326427007576	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
326427007577	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
326427007578	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
326427007579	TAP-like protein; Region: Abhydrolase_4; pfam08386
326427007580	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
326427007581	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
326427007582	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
326427007583	hypothetical protein; Provisional; Region: PRK06446
326427007584	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
326427007585	metal binding site [ion binding]; metal-binding site
326427007586	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
326427007587	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
326427007588	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
326427007589	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427007590	dimer interface [polypeptide binding]; other site
326427007591	conserved gate region; other site
326427007592	putative PBP binding loops; other site
326427007593	ABC-ATPase subunit interface; other site
326427007594	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427007595	dimer interface [polypeptide binding]; other site
326427007596	conserved gate region; other site
326427007597	putative PBP binding loops; other site
326427007598	ABC-ATPase subunit interface; other site
326427007599	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
326427007600	anti sigma factor interaction site; other site
326427007601	regulatory phosphorylation site [posttranslational modification]; other site
326427007602	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
326427007603	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326427007604	ATP binding site [chemical binding]; other site
326427007605	Mg2+ binding site [ion binding]; other site
326427007606	G-X-G motif; other site
326427007607	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
326427007608	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326427007609	ligand binding site [chemical binding]; other site
326427007610	flexible hinge region; other site
326427007611	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
326427007612	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
326427007613	HEAT repeats; Region: HEAT_2; pfam13646
326427007614	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
326427007615	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
326427007616	Walker A/P-loop; other site
326427007617	ATP binding site [chemical binding]; other site
326427007618	Q-loop/lid; other site
326427007619	ABC transporter signature motif; other site
326427007620	Walker B; other site
326427007621	D-loop; other site
326427007622	H-loop/switch region; other site
326427007623	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
326427007624	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
326427007625	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
326427007626	acyl-activating enzyme (AAE) consensus motif; other site
326427007627	putative AMP binding site [chemical binding]; other site
326427007628	putative active site [active]
326427007629	putative CoA binding site [chemical binding]; other site
326427007630	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
326427007631	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
326427007632	TM-ABC transporter signature motif; other site
326427007633	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
326427007634	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
326427007635	TM-ABC transporter signature motif; other site
326427007636	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
326427007637	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
326427007638	putative ligand binding site [chemical binding]; other site
326427007639	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
326427007640	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
326427007641	Walker A/P-loop; other site
326427007642	ATP binding site [chemical binding]; other site
326427007643	Q-loop/lid; other site
326427007644	ABC transporter signature motif; other site
326427007645	Walker B; other site
326427007646	D-loop; other site
326427007647	H-loop/switch region; other site
326427007648	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
326427007649	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
326427007650	acyl-activating enzyme (AAE) consensus motif; other site
326427007651	active site
326427007652	AMP binding site [chemical binding]; other site
326427007653	CoA binding site [chemical binding]; other site
326427007654	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
326427007655	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
326427007656	active site
326427007657	NAD binding site [chemical binding]; other site
326427007658	metal binding site [ion binding]; metal-binding site
326427007659	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
326427007660	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
326427007661	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
326427007662	ammonium transporter; Region: amt; TIGR00836
326427007663	Probable zinc-binding domain; Region: zf-trcl; pfam13451
326427007664	CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272
326427007665	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326427007666	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
326427007667	HlyD family secretion protein; Region: HlyD_3; pfam13437
326427007668	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
326427007669	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
326427007670	Walker A/P-loop; other site
326427007671	ATP binding site [chemical binding]; other site
326427007672	Q-loop/lid; other site
326427007673	ABC transporter signature motif; other site
326427007674	Walker B; other site
326427007675	D-loop; other site
326427007676	H-loop/switch region; other site
326427007677	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
326427007678	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
326427007679	FtsX-like permease family; Region: FtsX; pfam02687
326427007680	Bacterial SH3 domain; Region: SH3_3; cl17532
326427007681	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
326427007682	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
326427007683	hydroxyglutarate oxidase; Provisional; Region: PRK11728
326427007684	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
326427007685	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326427007686	catalytic residue [active]
326427007687	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
326427007688	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
326427007689	active site
326427007690	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
326427007691	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427007692	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
326427007693	trimer interface [polypeptide binding]; other site
326427007694	active site
326427007695	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
326427007696	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
326427007697	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
326427007698	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
326427007699	Fe-S cluster binding site [ion binding]; other site
326427007700	active site
326427007701	DNA methylase; Region: N6_N4_Mtase; pfam01555
326427007702	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427007703	S-adenosylmethionine binding site [chemical binding]; other site
326427007704	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
326427007705	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
326427007706	Probable Catalytic site; other site
326427007707	MoxR-like ATPases [General function prediction only]; Region: COG0714
326427007708	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427007709	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427007710	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
326427007711	DNA-binding site [nucleotide binding]; DNA binding site
326427007712	RNA-binding motif; other site
326427007713	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
326427007714	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
326427007715	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
326427007716	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
326427007717	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
326427007718	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
326427007719	ATP-grasp domain; Region: ATP-grasp_4; cl17255
326427007720	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
326427007721	IMP binding site; other site
326427007722	dimer interface [polypeptide binding]; other site
326427007723	interdomain contacts; other site
326427007724	partial ornithine binding site; other site
326427007725	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
326427007726	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
326427007727	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
326427007728	Walker A/P-loop; other site
326427007729	ATP binding site [chemical binding]; other site
326427007730	Q-loop/lid; other site
326427007731	ABC transporter signature motif; other site
326427007732	Walker B; other site
326427007733	D-loop; other site
326427007734	H-loop/switch region; other site
326427007735	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326427007736	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
326427007737	phosphopeptide binding site; other site
326427007738	Clostripain family; Region: Peptidase_C11; pfam03415
326427007739	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
326427007740	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
326427007741	dimer interface [polypeptide binding]; other site
326427007742	phosphorylation site [posttranslational modification]
326427007743	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427007744	ATP binding site [chemical binding]; other site
326427007745	Mg2+ binding site [ion binding]; other site
326427007746	G-X-G motif; other site
326427007747	mevalonate kinase; Region: mevalon_kin; TIGR00549
326427007748	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
326427007749	The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320
326427007750	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
326427007751	putative tRNA-binding site [nucleotide binding]; other site
326427007752	B3/4 domain; Region: B3_4; pfam03483
326427007753	tRNA synthetase B5 domain; Region: B5; smart00874
326427007754	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
326427007755	dimer interface [polypeptide binding]; other site
326427007756	motif 1; other site
326427007757	motif 3; other site
326427007758	motif 2; other site
326427007759	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
326427007760	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
326427007761	putative acyltransferase; Provisional; Region: PRK05790
326427007762	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
326427007763	dimer interface [polypeptide binding]; other site
326427007764	active site
326427007765	Response regulator receiver domain; Region: Response_reg; pfam00072
326427007766	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427007767	active site
326427007768	phosphorylation site [posttranslational modification]
326427007769	intermolecular recognition site; other site
326427007770	dimerization interface [polypeptide binding]; other site
326427007771	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
326427007772	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
326427007773	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427007774	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
326427007775	ferredoxin-NADP+ reductase; Region: PLN02852
326427007776	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
326427007777	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
326427007778	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
326427007779	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
326427007780	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
326427007781	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
326427007782	nucleophilic elbow; other site
326427007783	catalytic triad; other site
326427007784	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
326427007785	nickel binding site [ion binding]; other site
326427007786	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
326427007787	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
326427007788	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
326427007789	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
326427007790	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
326427007791	catalytic loop [active]
326427007792	iron binding site [ion binding]; other site
326427007793	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
326427007794	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
326427007795	dimer interface [polypeptide binding]; other site
326427007796	[2Fe-2S] cluster binding site [ion binding]; other site
326427007797	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
326427007798	SLBB domain; Region: SLBB; pfam10531
326427007799	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
326427007800	bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571
326427007801	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
326427007802	putative dimer interface [polypeptide binding]; other site
326427007803	[2Fe-2S] cluster binding site [ion binding]; other site
326427007804	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
326427007805	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
326427007806	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427007807	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427007808	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427007809	prolyl-tRNA synthetase; Provisional; Region: PRK08661
326427007810	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
326427007811	dimer interface [polypeptide binding]; other site
326427007812	motif 1; other site
326427007813	active site
326427007814	motif 2; other site
326427007815	motif 3; other site
326427007816	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
326427007817	anticodon binding site; other site
326427007818	zinc-binding site [ion binding]; other site
326427007819	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
326427007820	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
326427007821	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
326427007822	alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103
326427007823	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
326427007824	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
326427007825	Ca binding site [ion binding]; other site
326427007826	active site
326427007827	catalytic site [active]
326427007828	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
326427007829	heat shock protein 90; Provisional; Region: PRK05218
326427007830	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427007831	ATP binding site [chemical binding]; other site
326427007832	Mg2+ binding site [ion binding]; other site
326427007833	G-X-G motif; other site
326427007834	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
326427007835	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326427007836	FeS/SAM binding site; other site
326427007837	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
326427007838	antiporter inner membrane protein; Provisional; Region: PRK11670
326427007839	Domain of unknown function DUF59; Region: DUF59; pfam01883
326427007840	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
326427007841	Predicted transcriptional regulator [Transcription]; Region: COG2345
326427007842	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
326427007843	putative DNA binding site [nucleotide binding]; other site
326427007844	putative Zn2+ binding site [ion binding]; other site
326427007845	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
326427007846	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
326427007847	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
326427007848	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427007849	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427007850	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
326427007851	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
326427007852	active site
326427007853	PHP Thumb interface [polypeptide binding]; other site
326427007854	metal binding site [ion binding]; metal-binding site
326427007855	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
326427007856	generic binding surface II; other site
326427007857	generic binding surface I; other site
326427007858	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
326427007859	Aspartase; Region: Aspartase; cd01357
326427007860	active sites [active]
326427007861	tetramer interface [polypeptide binding]; other site
326427007862	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
326427007863	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
326427007864	Walker A/P-loop; other site
326427007865	ATP binding site [chemical binding]; other site
326427007866	Q-loop/lid; other site
326427007867	ABC transporter signature motif; other site
326427007868	Walker B; other site
326427007869	D-loop; other site
326427007870	H-loop/switch region; other site
326427007871	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
326427007872	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
326427007873	Walker A/P-loop; other site
326427007874	ATP binding site [chemical binding]; other site
326427007875	Q-loop/lid; other site
326427007876	ABC transporter signature motif; other site
326427007877	Walker B; other site
326427007878	D-loop; other site
326427007879	H-loop/switch region; other site
326427007880	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
326427007881	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326427007882	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326427007883	catalytic residue [active]
326427007884	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
326427007885	putative active site [active]
326427007886	catalytic residue [active]
326427007887	methionine sulfoxide reductase A; Provisional; Region: PRK14054
326427007888	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
326427007889	Protein of unknown function (DUF4013); Region: DUF4013; pfam13197
326427007890	Protein of unknown function (DUF4013); Region: DUF4013; pfam13197
326427007891	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
326427007892	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
326427007893	putative MPT binding site; other site
326427007894	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
326427007895	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
326427007896	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
326427007897	dimer interface [polypeptide binding]; other site
326427007898	active site
326427007899	motif 1; other site
326427007900	motif 2; other site
326427007901	motif 3; other site
326427007902	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
326427007903	anticodon binding site; other site
326427007904	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
326427007905	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427007906	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427007907	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
326427007908	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
326427007909	Walker A/P-loop; other site
326427007910	ATP binding site [chemical binding]; other site
326427007911	Q-loop/lid; other site
326427007912	ABC transporter signature motif; other site
326427007913	Walker B; other site
326427007914	D-loop; other site
326427007915	H-loop/switch region; other site
326427007916	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
326427007917	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
326427007918	active site
326427007919	Substrate binding site; other site
326427007920	Mg++ binding site; other site
326427007921	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
326427007922	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
326427007923	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427007924	active site
326427007925	phosphorylation site [posttranslational modification]
326427007926	intermolecular recognition site; other site
326427007927	dimerization interface [polypeptide binding]; other site
326427007928	ANTAR domain; Region: ANTAR; pfam03861
326427007929	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
326427007930	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
326427007931	active site
326427007932	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
326427007933	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
326427007934	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
326427007935	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
326427007936	alanine racemase; Reviewed; Region: alr; PRK00053
326427007937	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
326427007938	active site
326427007939	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
326427007940	dimer interface [polypeptide binding]; other site
326427007941	substrate binding site [chemical binding]; other site
326427007942	catalytic residues [active]
326427007943	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
326427007944	16S/18S rRNA binding site [nucleotide binding]; other site
326427007945	S13e-L30e interaction site [polypeptide binding]; other site
326427007946	25S rRNA binding site [nucleotide binding]; other site
326427007947	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
326427007948	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
326427007949	RNase E interface [polypeptide binding]; other site
326427007950	trimer interface [polypeptide binding]; other site
326427007951	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
326427007952	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
326427007953	RNase E interface [polypeptide binding]; other site
326427007954	trimer interface [polypeptide binding]; other site
326427007955	active site
326427007956	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
326427007957	putative nucleic acid binding region [nucleotide binding]; other site
326427007958	G-X-X-G motif; other site
326427007959	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
326427007960	RNA binding site [nucleotide binding]; other site
326427007961	domain interface; other site
326427007962	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
326427007963	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
326427007964	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
326427007965	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
326427007966	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
326427007967	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
326427007968	pantothenate kinase; Provisional; Region: PRK05439
326427007969	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
326427007970	ATP-binding site [chemical binding]; other site
326427007971	CoA-binding site [chemical binding]; other site
326427007972	Mg2+-binding site [ion binding]; other site
326427007973	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
326427007974	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
326427007975	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
326427007976	acyl-activating enzyme (AAE) consensus motif; other site
326427007977	acyl-activating enzyme (AAE) consensus motif; other site
326427007978	putative AMP binding site [chemical binding]; other site
326427007979	putative active site [active]
326427007980	putative CoA binding site [chemical binding]; other site
326427007981	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
326427007982	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
326427007983	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
326427007984	acyl-activating enzyme (AAE) consensus motif; other site
326427007985	acyl-activating enzyme (AAE) consensus motif; other site
326427007986	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
326427007987	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
326427007988	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
326427007989	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
326427007990	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
326427007991	Zn2+ binding site [ion binding]; other site
326427007992	Mg2+ binding site [ion binding]; other site
326427007993	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
326427007994	synthetase active site [active]
326427007995	NTP binding site [chemical binding]; other site
326427007996	metal binding site [ion binding]; metal-binding site
326427007997	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
326427007998	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
326427007999	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
326427008000	endonuclease III; Region: ENDO3c; smart00478
326427008001	minor groove reading motif; other site
326427008002	helix-hairpin-helix signature motif; other site
326427008003	substrate binding pocket [chemical binding]; other site
326427008004	active site
326427008005	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
326427008006	Protein of unknown function (DUF456); Region: DUF456; pfam04306
326427008007	GAF domain; Region: GAF; cl17456
326427008008	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427008009	dimer interface [polypeptide binding]; other site
326427008010	phosphorylation site [posttranslational modification]
326427008011	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427008012	ATP binding site [chemical binding]; other site
326427008013	Mg2+ binding site [ion binding]; other site
326427008014	G-X-G motif; other site
326427008015	Response regulator receiver domain; Region: Response_reg; pfam00072
326427008016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427008017	active site
326427008018	phosphorylation site [posttranslational modification]
326427008019	intermolecular recognition site; other site
326427008020	dimerization interface [polypeptide binding]; other site
326427008021	NAD synthetase; Reviewed; Region: nadE; PRK02628
326427008022	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
326427008023	multimer interface [polypeptide binding]; other site
326427008024	active site
326427008025	catalytic triad [active]
326427008026	protein interface 1 [polypeptide binding]; other site
326427008027	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
326427008028	homodimer interface [polypeptide binding]; other site
326427008029	NAD binding pocket [chemical binding]; other site
326427008030	ATP binding pocket [chemical binding]; other site
326427008031	Mg binding site [ion binding]; other site
326427008032	active-site loop [active]
326427008033	succinic semialdehyde dehydrogenase; Region: PLN02278
326427008034	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
326427008035	tetramerization interface [polypeptide binding]; other site
326427008036	NAD(P) binding site [chemical binding]; other site
326427008037	catalytic residues [active]
326427008038	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
326427008039	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
326427008040	Phosphoglycerate mutase family; Region: PGAM; smart00855
326427008041	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
326427008042	Amidase; Region: Amidase; pfam01425
326427008043	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
326427008044	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
326427008045	ATP-grasp domain; Region: ATP-grasp_4; cl17255
326427008046	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
326427008047	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
326427008048	carboxyltransferase (CT) interaction site; other site
326427008049	biotinylation site [posttranslational modification]; other site
326427008050	Cupin domain; Region: Cupin_2; pfam07883
326427008051	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
326427008052	dimerization interface [polypeptide binding]; other site
326427008053	putative DNA binding site [nucleotide binding]; other site
326427008054	putative Zn2+ binding site [ion binding]; other site
326427008055	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
326427008056	Low molecular weight phosphatase family; Region: LMWPc; cd00115
326427008057	active site
326427008058	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
326427008059	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427008060	S-adenosylmethionine binding site [chemical binding]; other site
326427008061	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
326427008062	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326427008063	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
326427008064	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
326427008065	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
326427008066	Walker A/P-loop; other site
326427008067	ATP binding site [chemical binding]; other site
326427008068	Q-loop/lid; other site
326427008069	ABC transporter signature motif; other site
326427008070	Walker B; other site
326427008071	D-loop; other site
326427008072	H-loop/switch region; other site
326427008073	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
326427008074	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
326427008075	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
326427008076	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
326427008077	Probable transposase; Region: OrfB_IS605; pfam01385
326427008078	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
326427008079	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
326427008080	endonuclease IV; Provisional; Region: PRK01060
326427008081	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
326427008082	AP (apurinic/apyrimidinic) site pocket; other site
326427008083	DNA interaction; other site
326427008084	Metal-binding active site; metal-binding site
326427008085	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
326427008086	Helix-hairpin-helix motif; Region: HHH; pfam00633
326427008087	Esterase/lipase [General function prediction only]; Region: COG1647
326427008088	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427008089	GAF domain; Region: GAF_2; pfam13185
326427008090	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427008091	GAF domain; Region: GAF; pfam01590
326427008092	GAF domain; Region: GAF; pfam01590
326427008093	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
326427008094	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
326427008095	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
326427008096	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427008097	ATP binding site [chemical binding]; other site
326427008098	Mg2+ binding site [ion binding]; other site
326427008099	G-X-G motif; other site
326427008100	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
326427008101	anti sigma factor interaction site; other site
326427008102	regulatory phosphorylation site [posttranslational modification]; other site
326427008103	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
326427008104	anti sigma factor interaction site; other site
326427008105	regulatory phosphorylation site [posttranslational modification]; other site
326427008106	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
326427008107	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
326427008108	hinge; other site
326427008109	active site
326427008110	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
326427008111	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
326427008112	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
326427008113	putative active site [active]
326427008114	catalytic triad [active]
326427008115	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
326427008116	PA/protease or protease-like domain interface [polypeptide binding]; other site
326427008117	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
326427008118	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
326427008119	hypothetical protein; Validated; Region: PRK07682
326427008120	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326427008121	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427008122	homodimer interface [polypeptide binding]; other site
326427008123	catalytic residue [active]
326427008124	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326427008125	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326427008126	DNA binding residues [nucleotide binding]
326427008127	dimerization interface [polypeptide binding]; other site
326427008128	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
326427008129	Kelch domain; Region: Kelch; smart00612
326427008130	Kelch domain; Region: Kelch; smart00612
326427008131	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
326427008132	Kelch motif; Region: Kelch_1; pfam01344
326427008133	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427008134	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
326427008135	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427008136	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
326427008137	Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287
326427008138	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234
326427008139	homoserine dehydrogenase; Provisional; Region: PRK06270
326427008140	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
326427008141	NAD(P) binding pocket [chemical binding]; other site
326427008142	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
326427008143	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
326427008144	AAA ATPase domain; Region: AAA_16; pfam13191
326427008145	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326427008146	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326427008147	DNA binding residues [nucleotide binding]
326427008148	dimerization interface [polypeptide binding]; other site
326427008149	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
326427008150	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
326427008151	putative ligand binding site [chemical binding]; other site
326427008152	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
326427008153	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
326427008154	Walker A/P-loop; other site
326427008155	ATP binding site [chemical binding]; other site
326427008156	Q-loop/lid; other site
326427008157	ABC transporter signature motif; other site
326427008158	Walker B; other site
326427008159	D-loop; other site
326427008160	H-loop/switch region; other site
326427008161	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
326427008162	Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172
326427008163	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
326427008164	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
326427008165	TM-ABC transporter signature motif; other site
326427008166	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326427008167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427008168	active site
326427008169	phosphorylation site [posttranslational modification]
326427008170	intermolecular recognition site; other site
326427008171	dimerization interface [polypeptide binding]; other site
326427008172	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326427008173	DNA binding residues [nucleotide binding]
326427008174	dimerization interface [polypeptide binding]; other site
326427008175	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
326427008176	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427008177	active site
326427008178	phosphorylation site [posttranslational modification]
326427008179	intermolecular recognition site; other site
326427008180	dimerization interface [polypeptide binding]; other site
326427008181	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
326427008182	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
326427008183	Walker A/P-loop; other site
326427008184	ATP binding site [chemical binding]; other site
326427008185	Q-loop/lid; other site
326427008186	ABC transporter signature motif; other site
326427008187	Walker B; other site
326427008188	D-loop; other site
326427008189	H-loop/switch region; other site
326427008190	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
326427008191	ATP binding site [chemical binding]; other site
326427008192	Mg2+ binding site [ion binding]; other site
326427008193	G-X-G motif; other site
326427008194	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
326427008195	Double zinc ribbon; Region: DZR; pfam12773
326427008196	Protease prsW family; Region: PrsW-protease; pfam13367
326427008197	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
326427008198	putative active site pocket [active]
326427008199	4-fold oligomerization interface [polypeptide binding]; other site
326427008200	metal binding residues [ion binding]; metal-binding site
326427008201	3-fold/trimer interface [polypeptide binding]; other site
326427008202	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
326427008203	putative metal binding site [ion binding]; other site
326427008204	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
326427008205	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
326427008206	active site
326427008207	histidinol-phosphate aminotransferase; Provisional; Region: PLN03026
326427008208	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326427008209	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427008210	homodimer interface [polypeptide binding]; other site
326427008211	catalytic residue [active]
326427008212	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
326427008213	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
326427008214	dimer interface [polypeptide binding]; other site
326427008215	active site
326427008216	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
326427008217	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427008218	Walker A motif; other site
326427008219	ATP binding site [chemical binding]; other site
326427008220	Walker B motif; other site
326427008221	arginine finger; other site
326427008222	DEAD-like helicases superfamily; Region: DEXDc; smart00487
326427008223	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326427008224	ATP binding site [chemical binding]; other site
326427008225	putative Mg++ binding site [ion binding]; other site
326427008226	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326427008227	ATP-binding site [chemical binding]; other site
326427008228	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
326427008229	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326427008230	ATP binding site [chemical binding]; other site
326427008231	putative Mg++ binding site [ion binding]; other site
326427008232	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326427008233	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
326427008234	nucleotide binding region [chemical binding]; other site
326427008235	ATP-binding site [chemical binding]; other site
326427008236	Methyltransferase domain; Region: Methyltransf_26; pfam13659
326427008237	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
326427008238	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
326427008239	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326427008240	ligand binding site [chemical binding]; other site
326427008241	flexible hinge region; other site
326427008242	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326427008243	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
326427008244	ligand binding site [chemical binding]; other site
326427008245	flexible hinge region; other site
326427008246	hypothetical protein; Validated; Region: PRK00110
326427008247	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
326427008248	active site
326427008249	putative DNA-binding cleft [nucleotide binding]; other site
326427008250	dimer interface [polypeptide binding]; other site
326427008251	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
326427008252	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
326427008253	putative [4Fe-4S] binding site [ion binding]; other site
326427008254	putative molybdopterin cofactor binding site [chemical binding]; other site
326427008255	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
326427008256	putative molybdopterin cofactor binding site; other site
326427008257	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
326427008258	Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450
326427008259	PGAP1-like protein; Region: PGAP1; pfam07819
326427008260	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
326427008261	GIY-YIG motif/motif A; other site
326427008262	putative active site [active]
326427008263	putative metal binding site [ion binding]; other site
326427008264	Protein of unknown function, DUF608; Region: DUF608; pfam04685
326427008265	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
326427008266	G8 domain; Region: G8; pfam10162
326427008267	Right handed beta helix region; Region: Beta_helix; pfam13229
326427008268	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
326427008269	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
326427008270	active site
326427008271	HIGH motif; other site
326427008272	KMSK motif region; other site
326427008273	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
326427008274	tRNA binding surface [nucleotide binding]; other site
326427008275	anticodon binding site; other site
326427008276	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
326427008277	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326427008278	active site
326427008279	motif I; other site
326427008280	motif II; other site
326427008281	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326427008282	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
326427008283	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
326427008284	putative active site [active]
326427008285	putative metal binding site [ion binding]; other site
326427008286	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
326427008287	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
326427008288	GIY-YIG motif/motif A; other site
326427008289	active site
326427008290	catalytic site [active]
326427008291	putative DNA binding site [nucleotide binding]; other site
326427008292	metal binding site [ion binding]; metal-binding site
326427008293	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
326427008294	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
326427008295	DNA binding site [nucleotide binding]
326427008296	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
326427008297	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
326427008298	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
326427008299	Protein of unknown function DUF58; Region: DUF58; pfam01882
326427008300	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
326427008301	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
326427008302	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326427008303	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
326427008304	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326427008305	DNA binding residues [nucleotide binding]
326427008306	carboxyl-terminal processing protease; Provisional; Region: PLN00049
326427008307	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
326427008308	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
326427008309	protein binding site [polypeptide binding]; other site
326427008310	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
326427008311	Domain interface; other site
326427008312	Peptide binding site; other site
326427008313	Active site tetrad [active]
326427008314	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
326427008315	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
326427008316	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
326427008317	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
326427008318	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326427008319	MarR family; Region: MarR; pfam01047
326427008320	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
326427008321	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
326427008322	active site
326427008323	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
326427008324	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
326427008325	4Fe-4S binding domain; Region: Fer4_2; pfam12797
326427008326	Cysteine-rich domain; Region: CCG; pfam02754
326427008327	Cysteine-rich domain; Region: CCG; pfam02754
326427008328	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
326427008329	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
326427008330	Walker A/P-loop; other site
326427008331	ATP binding site [chemical binding]; other site
326427008332	Q-loop/lid; other site
326427008333	ABC transporter signature motif; other site
326427008334	Walker B; other site
326427008335	D-loop; other site
326427008336	H-loop/switch region; other site
326427008337	TOBE domain; Region: TOBE_2; pfam08402
326427008338	FOG: CBS domain [General function prediction only]; Region: COG0517
326427008339	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc; cd04584
326427008340	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
326427008341	amidase catalytic site [active]
326427008342	Zn binding residues [ion binding]; other site
326427008343	substrate binding site [chemical binding]; other site
326427008344	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
326427008345	PA14 domain; Region: PA14; cl08459
326427008346	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
326427008347	Cache domain; Region: Cache_1; pfam02743
326427008348	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
326427008349	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326427008350	dimerization interface [polypeptide binding]; other site
326427008351	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427008352	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427008353	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427008354	dimer interface [polypeptide binding]; other site
326427008355	phosphorylation site [posttranslational modification]
326427008356	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427008357	ATP binding site [chemical binding]; other site
326427008358	Mg2+ binding site [ion binding]; other site
326427008359	G-X-G motif; other site
326427008360	Response regulator receiver domain; Region: Response_reg; pfam00072
326427008361	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427008362	active site
326427008363	phosphorylation site [posttranslational modification]
326427008364	intermolecular recognition site; other site
326427008365	dimerization interface [polypeptide binding]; other site
326427008366	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326427008367	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427008368	dimer interface [polypeptide binding]; other site
326427008369	phosphorylation site [posttranslational modification]
326427008370	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427008371	ATP binding site [chemical binding]; other site
326427008372	Mg2+ binding site [ion binding]; other site
326427008373	G-X-G motif; other site
326427008374	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
326427008375	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
326427008376	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
326427008377	Walker A/P-loop; other site
326427008378	ATP binding site [chemical binding]; other site
326427008379	Q-loop/lid; other site
326427008380	ABC transporter signature motif; other site
326427008381	Walker B; other site
326427008382	D-loop; other site
326427008383	H-loop/switch region; other site
326427008384	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
326427008385	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
326427008386	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
326427008387	Walker A/P-loop; other site
326427008388	ATP binding site [chemical binding]; other site
326427008389	Q-loop/lid; other site
326427008390	ABC transporter signature motif; other site
326427008391	Walker B; other site
326427008392	D-loop; other site
326427008393	H-loop/switch region; other site
326427008394	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
326427008395	Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cd09224
326427008396	subunit interface [polypeptide binding]; other site
326427008397	Heme binding sites [chemical binding]; other site
326427008398	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
326427008399	UbiA prenyltransferase family; Region: UbiA; pfam01040
326427008400	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
326427008401	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
326427008402	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
326427008403	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
326427008404	putative active site [active]
326427008405	putative FMN binding site [chemical binding]; other site
326427008406	putative substrate binding site [chemical binding]; other site
326427008407	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
326427008408	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
326427008409	dimer interface [polypeptide binding]; other site
326427008410	PYR/PP interface [polypeptide binding]; other site
326427008411	TPP binding site [chemical binding]; other site
326427008412	substrate binding site [chemical binding]; other site
326427008413	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
326427008414	Domain of unknown function; Region: EKR; smart00890
326427008415	4Fe-4S binding domain; Region: Fer4_6; pfam12837
326427008416	4Fe-4S binding domain; Region: Fer4; pfam00037
326427008417	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
326427008418	TPP-binding site [chemical binding]; other site
326427008419	dimer interface [polypeptide binding]; other site
326427008420	Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492
326427008421	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427008422	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
326427008423	putative ADP-binding pocket [chemical binding]; other site
326427008424	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
326427008425	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
326427008426	catalytic motif [active]
326427008427	Zn binding site [ion binding]; other site
326427008428	RibD C-terminal domain; Region: RibD_C; cl17279
326427008429	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
326427008430	Lumazine binding domain; Region: Lum_binding; pfam00677
326427008431	Lumazine binding domain; Region: Lum_binding; pfam00677
326427008432	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
326427008433	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
326427008434	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
326427008435	homopentamer interface [polypeptide binding]; other site
326427008436	active site
326427008437	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
326427008438	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
326427008439	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
326427008440	catalytic site [active]
326427008441	subunit interface [polypeptide binding]; other site
326427008442	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
326427008443	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
326427008444	active site
326427008445	octamer interface [polypeptide binding]; other site
326427008446	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
326427008447	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
326427008448	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
326427008449	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
326427008450	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
326427008451	FOG: CBS domain [General function prediction only]; Region: COG0517
326427008452	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
326427008453	PAS domain S-box; Region: sensory_box; TIGR00229
326427008454	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427008455	putative active site [active]
326427008456	heme pocket [chemical binding]; other site
326427008457	PAS fold; Region: PAS_4; pfam08448
326427008458	PAS domain S-box; Region: sensory_box; TIGR00229
326427008459	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427008460	putative active site [active]
326427008461	heme pocket [chemical binding]; other site
326427008462	PAS fold; Region: PAS_4; pfam08448
326427008463	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427008464	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
326427008465	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427008466	S-adenosylmethionine binding site [chemical binding]; other site
326427008467	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427008468	binding surface
326427008469	Tetratricopeptide repeat; Region: TPR_16; pfam13432
326427008470	TPR motif; other site
326427008471	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
326427008472	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
326427008473	catalytic loop [active]
326427008474	iron binding site [ion binding]; other site
326427008475	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
326427008476	Cytochrome c; Region: Cytochrom_C; pfam00034
326427008477	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
326427008478	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
326427008479	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
326427008480	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
326427008481	UbiA prenyltransferase family; Region: UbiA; pfam01040
326427008482	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
326427008483	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427008484	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427008485	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
326427008486	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
326427008487	Ligand Binding Site [chemical binding]; other site
326427008488	TilS substrate binding domain; Region: TilS; pfam09179
326427008489	TilS substrate C-terminal domain; Region: TilS_C; smart00977
326427008490	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
326427008491	active site
326427008492	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
326427008493	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427008494	Walker A motif; other site
326427008495	ATP binding site [chemical binding]; other site
326427008496	Walker B motif; other site
326427008497	arginine finger; other site
326427008498	Peptidase family M41; Region: Peptidase_M41; pfam01434
326427008499	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427008500	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
326427008501	putative active site [active]
326427008502	heme pocket [chemical binding]; other site
326427008503	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427008504	putative active site [active]
326427008505	heme pocket [chemical binding]; other site
326427008506	PAS fold; Region: PAS_4; pfam08448
326427008507	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427008508	putative active site [active]
326427008509	heme pocket [chemical binding]; other site
326427008510	PAS fold; Region: PAS_4; pfam08448
326427008511	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
326427008512	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
326427008513	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326427008514	ligand binding site [chemical binding]; other site
326427008515	flexible hinge region; other site
326427008516	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
326427008517	putative switch regulator; other site
326427008518	non-specific DNA interactions [nucleotide binding]; other site
326427008519	DNA binding site [nucleotide binding]
326427008520	sequence specific DNA binding site [nucleotide binding]; other site
326427008521	putative cAMP binding site [chemical binding]; other site
326427008522	signal recognition particle protein; Provisional; Region: PRK10867
326427008523	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
326427008524	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
326427008525	P loop; other site
326427008526	GTP binding site [chemical binding]; other site
326427008527	Signal peptide binding domain; Region: SRP_SPB; pfam02978
326427008528	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
326427008529	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
326427008530	KH domain; Region: KH_4; pfam13083
326427008531	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
326427008532	RimM N-terminal domain; Region: RimM; pfam01782
326427008533	PRC-barrel domain; Region: PRC; pfam05239
326427008534	Response regulator receiver domain; Region: Response_reg; pfam00072
326427008535	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427008536	active site
326427008537	phosphorylation site [posttranslational modification]
326427008538	intermolecular recognition site; other site
326427008539	dimerization interface [polypeptide binding]; other site
326427008540	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427008541	GAF domain; Region: GAF; pfam01590
326427008542	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
326427008543	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427008544	dimer interface [polypeptide binding]; other site
326427008545	phosphorylation site [posttranslational modification]
326427008546	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427008547	ATP binding site [chemical binding]; other site
326427008548	Mg2+ binding site [ion binding]; other site
326427008549	G-X-G motif; other site
326427008550	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
326427008551	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
326427008552	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
326427008553	metal binding site [ion binding]; metal-binding site
326427008554	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
326427008555	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
326427008556	purine monophosphate binding site [chemical binding]; other site
326427008557	dimer interface [polypeptide binding]; other site
326427008558	putative catalytic residues [active]
326427008559	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
326427008560	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
326427008561	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
326427008562	Transcriptional regulators [Transcription]; Region: MarR; COG1846
326427008563	MarR family; Region: MarR_2; pfam12802
326427008564	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
326427008565	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
326427008566	G1 box; other site
326427008567	GTP/Mg2+ binding site [chemical binding]; other site
326427008568	G2 box; other site
326427008569	Switch I region; other site
326427008570	G3 box; other site
326427008571	Switch II region; other site
326427008572	G4 box; other site
326427008573	G5 box; other site
326427008574	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
326427008575	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
326427008576	Winged helix-turn helix; Region: HTH_29; pfam13551
326427008577	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427008578	GAF domain; Region: GAF_3; pfam13492
326427008579	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
326427008580	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427008581	putative active site [active]
326427008582	heme pocket [chemical binding]; other site
326427008583	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427008584	dimer interface [polypeptide binding]; other site
326427008585	phosphorylation site [posttranslational modification]
326427008586	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427008587	ATP binding site [chemical binding]; other site
326427008588	Mg2+ binding site [ion binding]; other site
326427008589	G-X-G motif; other site
326427008590	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
326427008591	Domain of unknown function DUF11; Region: DUF11; cl17728
326427008592	Protein of unknown function DUF58; Region: DUF58; pfam01882
326427008593	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
326427008594	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
326427008595	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
326427008596	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
326427008597	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
326427008598	motif II; other site
326427008599	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326427008600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427008601	active site
326427008602	phosphorylation site [posttranslational modification]
326427008603	intermolecular recognition site; other site
326427008604	dimerization interface [polypeptide binding]; other site
326427008605	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
326427008606	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
326427008607	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
326427008608	NAD(P) binding site [chemical binding]; other site
326427008609	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427008610	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
326427008611	Coenzyme A binding pocket [chemical binding]; other site
326427008612	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
326427008613	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
326427008614	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
326427008615	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
326427008616	HSP70 interaction site [polypeptide binding]; other site
326427008617	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
326427008618	substrate binding site [polypeptide binding]; other site
326427008619	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
326427008620	Zn binding sites [ion binding]; other site
326427008621	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
326427008622	dimer interface [polypeptide binding]; other site
326427008623	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
326427008624	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
326427008625	nucleotide binding site [chemical binding]; other site
326427008626	NEF interaction site [polypeptide binding]; other site
326427008627	SBD interface [polypeptide binding]; other site
326427008628	GrpE; Region: GrpE; pfam01025
326427008629	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
326427008630	dimer interface [polypeptide binding]; other site
326427008631	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
326427008632	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
326427008633	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
326427008634	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
326427008635	hypothetical protein; Provisional; Region: PRK06446
326427008636	metal binding site [ion binding]; metal-binding site
326427008637	dimer interface [polypeptide binding]; other site
326427008638	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
326427008639	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
326427008640	metal-binding site [ion binding]
326427008641	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
326427008642	Soluble P-type ATPase [General function prediction only]; Region: COG4087
326427008643	AAA-like domain; Region: AAA_10; pfam12846
326427008644	Domain of unknown function DUF87; Region: DUF87; pfam01935
326427008645	Zonular occludens toxin (Zot); Region: Zot; cl17485
326427008646	NurA nuclease; Region: NurA; smart00933
326427008647	Domain of unknown function (DUF4338); Region: DUF4338; pfam14236
326427008648	6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478
326427008649	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
326427008650	active site
326427008651	ADP/pyrophosphate binding site [chemical binding]; other site
326427008652	dimerization interface [polypeptide binding]; other site
326427008653	allosteric effector site; other site
326427008654	fructose-1,6-bisphosphate binding site; other site
326427008655	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
326427008656	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
326427008657	dimer interface [polypeptide binding]; other site
326427008658	ssDNA binding site [nucleotide binding]; other site
326427008659	tetramer (dimer of dimers) interface [polypeptide binding]; other site
326427008660	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
326427008661	AsnC family; Region: AsnC_trans_reg; pfam01037
326427008662	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
326427008663	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
326427008664	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
326427008665	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
326427008666	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
326427008667	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
326427008668	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
326427008669	G-loop; other site
326427008670	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
326427008671	DNA binding site [nucleotide binding]
326427008672	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
326427008673	DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085
326427008674	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
326427008675	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
326427008676	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
326427008677	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
326427008678	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
326427008679	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
326427008680	RPB10 interaction site [polypeptide binding]; other site
326427008681	RPB1 interaction site [polypeptide binding]; other site
326427008682	RPB11 interaction site [polypeptide binding]; other site
326427008683	RPB3 interaction site [polypeptide binding]; other site
326427008684	RPB12 interaction site [polypeptide binding]; other site
326427008685	HAMP domain; Region: HAMP; pfam00672
326427008686	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427008687	dimer interface [polypeptide binding]; other site
326427008688	phosphorylation site [posttranslational modification]
326427008689	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427008690	ATP binding site [chemical binding]; other site
326427008691	Mg2+ binding site [ion binding]; other site
326427008692	G-X-G motif; other site
326427008693	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326427008694	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427008695	active site
326427008696	phosphorylation site [posttranslational modification]
326427008697	intermolecular recognition site; other site
326427008698	dimerization interface [polypeptide binding]; other site
326427008699	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326427008700	DNA binding site [nucleotide binding]
326427008701	hypothetical protein; Provisional; Region: PRK06148
326427008702	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
326427008703	active site
326427008704	ATP binding site [chemical binding]; other site
326427008705	substrate binding site [chemical binding]; other site
326427008706	Peptidase family M23; Region: Peptidase_M23; pfam01551
326427008707	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
326427008708	inhibitor-cofactor binding pocket; inhibition site
326427008709	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427008710	catalytic residue [active]
326427008711	alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103
326427008712	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
326427008713	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
326427008714	Ca binding site [ion binding]; other site
326427008715	active site
326427008716	catalytic site [active]
326427008717	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
326427008718	Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317
326427008719	active site
326427008720	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
326427008721	Ca binding site [ion binding]; other site
326427008722	catalytic site [active]
326427008723	Aamy_C domain; Region: Aamy_C; smart00632
326427008724	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
326427008725	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
326427008726	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
326427008727	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326427008728	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
326427008729	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326427008730	DNA binding residues [nucleotide binding]
326427008731	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
326427008732	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
326427008733	G1 box; other site
326427008734	putative GEF interaction site [polypeptide binding]; other site
326427008735	GTP/Mg2+ binding site [chemical binding]; other site
326427008736	Switch I region; other site
326427008737	G2 box; other site
326427008738	G3 box; other site
326427008739	Switch II region; other site
326427008740	G4 box; other site
326427008741	G5 box; other site
326427008742	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
326427008743	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
326427008744	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
326427008745	Cysteine-rich domain; Region: CCG; pfam02754
326427008746	Cysteine-rich domain; Region: CCG; pfam02754
326427008747	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
326427008748	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
326427008749	4Fe-4S binding domain; Region: Fer4; pfam00037
326427008750	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
326427008751	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427008752	Coenzyme A binding pocket [chemical binding]; other site
326427008753	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
326427008754	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
326427008755	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
326427008756	dimerization interface [polypeptide binding]; other site
326427008757	ligand binding site [chemical binding]; other site
326427008758	NADP binding site [chemical binding]; other site
326427008759	catalytic site [active]
326427008760	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
326427008761	AAA domain; Region: AAA_30; pfam13604
326427008762	Family description; Region: UvrD_C_2; pfam13538
326427008763	FtsX-like permease family; Region: FtsX; pfam02687
326427008764	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
326427008765	FtsX-like permease family; Region: FtsX; pfam02687
326427008766	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
326427008767	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
326427008768	Walker A/P-loop; other site
326427008769	ATP binding site [chemical binding]; other site
326427008770	Q-loop/lid; other site
326427008771	ABC transporter signature motif; other site
326427008772	Walker B; other site
326427008773	D-loop; other site
326427008774	H-loop/switch region; other site
326427008775	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
326427008776	HlyD family secretion protein; Region: HlyD_3; pfam13437
326427008777	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
326427008778	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
326427008779	NMT1/THI5 like; Region: NMT1; pfam09084
326427008780	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
326427008781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427008782	dimer interface [polypeptide binding]; other site
326427008783	conserved gate region; other site
326427008784	putative PBP binding loops; other site
326427008785	ABC-ATPase subunit interface; other site
326427008786	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
326427008787	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
326427008788	Cu(I) binding site [ion binding]; other site
326427008789	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
326427008790	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
326427008791	active site
326427008792	catalytic site [active]
326427008793	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
326427008794	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
326427008795	dimer interface [polypeptide binding]; other site
326427008796	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
326427008797	active site
326427008798	Fe binding site [ion binding]; other site
326427008799	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
326427008800	PAS domain; Region: PAS; smart00091
326427008801	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
326427008802	putative active site [active]
326427008803	heme pocket [chemical binding]; other site
326427008804	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427008805	dimer interface [polypeptide binding]; other site
326427008806	phosphorylation site [posttranslational modification]
326427008807	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427008808	ATP binding site [chemical binding]; other site
326427008809	Mg2+ binding site [ion binding]; other site
326427008810	G-X-G motif; other site
326427008811	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
326427008812	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
326427008813	Protein of unknown function (DUF512); Region: DUF512; pfam04459
326427008814	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427008815	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427008816	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427008817	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427008818	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
326427008819	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
326427008820	Zn2+ binding site [ion binding]; other site
326427008821	Mg2+ binding site [ion binding]; other site
326427008822	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
326427008823	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
326427008824	glutamine binding [chemical binding]; other site
326427008825	catalytic triad [active]
326427008826	short chain dehydrogenase; Provisional; Region: PRK06172
326427008827	classical (c) SDRs; Region: SDR_c; cd05233
326427008828	NAD(P) binding site [chemical binding]; other site
326427008829	active site
326427008830	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
326427008831	DNA binding site [nucleotide binding]
326427008832	active site
326427008833	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427008834	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326427008835	putative substrate translocation pore; other site
326427008836	Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083
326427008837	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
326427008838	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
326427008839	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
326427008840	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
326427008841	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
326427008842	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
326427008843	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
326427008844	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
326427008845	Walker A/P-loop; other site
326427008846	ATP binding site [chemical binding]; other site
326427008847	Q-loop/lid; other site
326427008848	ABC transporter signature motif; other site
326427008849	Walker B; other site
326427008850	D-loop; other site
326427008851	H-loop/switch region; other site
326427008852	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
326427008853	putative carbohydrate binding site [chemical binding]; other site
326427008854	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326427008855	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427008856	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
326427008857	potential frameshift: common BLAST hit: gi|156742705|ref|YP_001432834.1| glycosyl transferase family protein
326427008858	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
326427008859	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
326427008860	Probable Catalytic site; other site
326427008861	metal-binding site
326427008862	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427008863	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427008864	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427008865	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427008866	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
326427008867	Family description; Region: VCBS; pfam13517
326427008868	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
326427008869	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427008870	NAD(P) binding site [chemical binding]; other site
326427008871	active site
326427008872	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427008873	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326427008874	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
326427008875	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
326427008876	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
326427008877	catalytic residue [active]
326427008878	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
326427008879	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
326427008880	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
326427008881	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
326427008882	active site
326427008883	dimer interface [polypeptide binding]; other site
326427008884	effector binding site; other site
326427008885	TSCPD domain; Region: TSCPD; pfam12637
326427008886	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
326427008887	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
326427008888	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
326427008889	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
326427008890	TrkA-N domain; Region: TrkA_N; pfam02254
326427008891	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
326427008892	TrkA-N domain; Region: TrkA_N; pfam02254
326427008893	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
326427008894	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
326427008895	active site
326427008896	Predicted permeases [General function prediction only]; Region: COG0679
326427008897	Domain of unknown function DUF11; Region: DUF11; cl17728
326427008898	Uncharacterized protein conserved in archaea (DUF2180); Region: DUF2180; cl02017
326427008899	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
326427008900	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
326427008901	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
326427008902	active site
326427008903	Substrate binding site; other site
326427008904	Mg++ binding site; other site
326427008905	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
326427008906	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
326427008907	Cytochrome c; Region: Cytochrom_C; cl11414
326427008908	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
326427008909	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
326427008910	active site
326427008911	FMN binding site [chemical binding]; other site
326427008912	substrate binding site [chemical binding]; other site
326427008913	homotetramer interface [polypeptide binding]; other site
326427008914	catalytic residue [active]
326427008915	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326427008916	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427008917	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
326427008918	beta-galactosidase; Region: BGL; TIGR03356
326427008919	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
326427008920	ABC1 family; Region: ABC1; cl17513
326427008921	ABC1 family; Region: ABC1; cl17513
326427008922	Thioredoxin; Region: Thioredoxin_4; pfam13462
326427008923	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
326427008924	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
326427008925	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
326427008926	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
326427008927	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
326427008928	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
326427008929	FAD binding domain; Region: FAD_binding_4; pfam01565
326427008930	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
326427008931	PemK-like protein; Region: PemK; pfam02452
326427008932	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
326427008933	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
326427008934	non-specific DNA binding site [nucleotide binding]; other site
326427008935	salt bridge; other site
326427008936	sequence-specific DNA binding site [nucleotide binding]; other site
326427008937	Domain of unknown function (DUF955); Region: DUF955; cl01076
326427008938	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
326427008939	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
326427008940	acyl-activating enzyme (AAE) consensus motif; other site
326427008941	putative AMP binding site [chemical binding]; other site
326427008942	putative active site [active]
326427008943	putative CoA binding site [chemical binding]; other site
326427008944	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
326427008945	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
326427008946	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
326427008947	PGAP1-like protein; Region: PGAP1; pfam07819
326427008948	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
326427008949	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
326427008950	Ligand Binding Site [chemical binding]; other site
326427008951	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
326427008952	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
326427008953	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
326427008954	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
326427008955	G1 box; other site
326427008956	GTP/Mg2+ binding site [chemical binding]; other site
326427008957	G2 box; other site
326427008958	Switch I region; other site
326427008959	G3 box; other site
326427008960	Switch II region; other site
326427008961	G4 box; other site
326427008962	G5 box; other site
326427008963	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
326427008964	IHF dimer interface [polypeptide binding]; other site
326427008965	IHF - DNA interface [nucleotide binding]; other site
326427008966	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
326427008967	Zn binding site [ion binding]; other site
326427008968	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326427008969	Histidine kinase; Region: HisKA_3; pfam07730
326427008970	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427008971	ATP binding site [chemical binding]; other site
326427008972	Mg2+ binding site [ion binding]; other site
326427008973	G-X-G motif; other site
326427008974	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326427008975	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427008976	active site
326427008977	phosphorylation site [posttranslational modification]
326427008978	intermolecular recognition site; other site
326427008979	dimerization interface [polypeptide binding]; other site
326427008980	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326427008981	DNA binding residues [nucleotide binding]
326427008982	dimerization interface [polypeptide binding]; other site
326427008983	PUCC protein; Region: PUCC; pfam03209
326427008984	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427008985	putative substrate translocation pore; other site
326427008986	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
326427008987	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
326427008988	substrate binding site [chemical binding]; other site
326427008989	active site
326427008990	catalytic residues [active]
326427008991	heterodimer interface [polypeptide binding]; other site
326427008992	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
326427008993	AsnC family; Region: AsnC_trans_reg; pfam01037
326427008994	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
326427008995	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427008996	binding surface
326427008997	TPR motif; other site
326427008998	TPR repeat; Region: TPR_11; pfam13414
326427008999	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427009000	TPR motif; other site
326427009001	TPR repeat; Region: TPR_11; pfam13414
326427009002	binding surface
326427009003	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
326427009004	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
326427009005	active site
326427009006	multimer interface [polypeptide binding]; other site
326427009007	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
326427009008	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
326427009009	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
326427009010	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
326427009011	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
326427009012	substrate binding site [chemical binding]; other site
326427009013	ATP binding site [chemical binding]; other site
326427009014	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
326427009015	intersubunit interface [polypeptide binding]; other site
326427009016	active site
326427009017	catalytic residue [active]
326427009018	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
326427009019	CoA binding domain; Region: CoA_binding; smart00881
326427009020	CoA-ligase; Region: Ligase_CoA; pfam00549
326427009021	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427009022	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427009023	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326427009024	Histidine kinase; Region: HisKA_3; pfam07730
326427009025	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427009026	ATP binding site [chemical binding]; other site
326427009027	Mg2+ binding site [ion binding]; other site
326427009028	G-X-G motif; other site
326427009029	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
326427009030	[2Fe-2S] cluster binding site [ion binding]; other site
326427009031	PspC domain; Region: PspC; pfam04024
326427009032	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
326427009033	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
326427009034	active site
326427009035	metal binding site [ion binding]; metal-binding site
326427009036	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
326427009037	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
326427009038	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
326427009039	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427009040	Tetratricopeptide repeat; Region: TPR_9; pfam13371
326427009041	Transposase IS200 like; Region: Y1_Tnp; pfam01797
326427009042	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
326427009043	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427009044	binding surface
326427009045	TPR motif; other site
326427009046	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
326427009047	Bacterial transcriptional activator domain; Region: BTAD; smart01043
326427009048	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427009049	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427009050	TPR motif; other site
326427009051	binding surface
326427009052	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427009053	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
326427009054	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
326427009055	metal ion-dependent adhesion site (MIDAS); other site
326427009056	Cdc37 C terminal domain; Region: CDC37_C; cl07247
326427009057	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
326427009058	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
326427009059	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
326427009060	DctM-like transporters; Region: DctM; pfam06808
326427009061	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
326427009062	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
326427009063	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
326427009064	XdhC Rossmann domain; Region: XdhC_C; pfam13478
326427009065	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
326427009066	trimer interface [polypeptide binding]; other site
326427009067	dimer interface [polypeptide binding]; other site
326427009068	putative active site [active]
326427009069	cell division protein MraZ; Reviewed; Region: PRK00326
326427009070	MraZ protein; Region: MraZ; pfam02381
326427009071	MraZ protein; Region: MraZ; pfam02381
326427009072	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
326427009073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427009074	S-adenosylmethionine binding site [chemical binding]; other site
326427009075	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
326427009076	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
326427009077	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
326427009078	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
326427009079	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
326427009080	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
326427009081	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
326427009082	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
326427009083	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
326427009084	Mg++ binding site [ion binding]; other site
326427009085	putative catalytic motif [active]
326427009086	putative substrate binding site [chemical binding]; other site
326427009087	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
326427009088	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
326427009089	Rhomboid family; Region: Rhomboid; pfam01694
326427009090	cell division protein FtsW; Region: ftsW; TIGR02614
326427009091	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
326427009092	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
326427009093	active site
326427009094	homodimer interface [polypeptide binding]; other site
326427009095	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
326427009096	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
326427009097	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
326427009098	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
326427009099	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14649
326427009100	FAD binding domain; Region: FAD_binding_4; pfam01565
326427009101	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
326427009102	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
326427009103	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
326427009104	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
326427009105	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
326427009106	Cell division protein FtsQ; Region: FtsQ; pfam03799
326427009107	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
326427009108	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
326427009109	nucleotide binding site [chemical binding]; other site
326427009110	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
326427009111	Cell division protein FtsA; Region: FtsA; pfam14450
326427009112	cell division protein FtsZ; Validated; Region: PRK09330
326427009113	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
326427009114	nucleotide binding site [chemical binding]; other site
326427009115	SulA interaction site; other site
326427009116	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
326427009117	tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406
326427009118	active site
326427009119	HIGH motif; other site
326427009120	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
326427009121	KMSKS motif; other site
326427009122	This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840
326427009123	Bacterial SH3 domain; Region: SH3_3; pfam08239
326427009124	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326427009125	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326427009126	active site
326427009127	ATP binding site [chemical binding]; other site
326427009128	substrate binding site [chemical binding]; other site
326427009129	activation loop (A-loop); other site
326427009130	Double zinc ribbon; Region: DZR; pfam12773
326427009131	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
326427009132	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326427009133	phosphopeptide binding site; other site
326427009134	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
326427009135	CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507
326427009136	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
326427009137	putative active site [active]
326427009138	catalytic triad [active]
326427009139	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
326427009140	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427009141	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427009142	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
326427009143	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427009144	Coenzyme A binding pocket [chemical binding]; other site
326427009145	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427009146	S-adenosylmethionine binding site [chemical binding]; other site
326427009147	56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694
326427009148	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
326427009149	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
326427009150	putative homodimer interface [polypeptide binding]; other site
326427009151	putative active site pocket [active]
326427009152	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
326427009153	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
326427009154	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
326427009155	minor groove reading motif; other site
326427009156	helix-hairpin-helix signature motif; other site
326427009157	active site
326427009158	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
326427009159	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
326427009160	Chromate transporter; Region: Chromate_transp; pfam02417
326427009161	Low molecular weight phosphatase family; Region: LMWPc; cl00105
326427009162	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
326427009163	active site
326427009164	Peptidase family M23; Region: Peptidase_M23; pfam01551
326427009165	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
326427009166	Interdomain contacts; other site
326427009167	Cytokine receptor motif; other site
326427009168	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
326427009169	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
326427009170	peptide chain release factor 2; Validated; Region: prfB; PRK00578
326427009171	This domain is found in peptide chain release factors; Region: PCRF; smart00937
326427009172	RF-1 domain; Region: RF-1; pfam00472
326427009173	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
326427009174	nucleotide binding site/active site [active]
326427009175	HIT family signature motif; other site
326427009176	catalytic residue [active]
326427009177	Response regulator receiver domain; Region: Response_reg; pfam00072
326427009178	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427009179	active site
326427009180	phosphorylation site [posttranslational modification]
326427009181	intermolecular recognition site; other site
326427009182	dimerization interface [polypeptide binding]; other site
326427009183	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
326427009184	active site
326427009185	Bacterial transcriptional activator domain; Region: BTAD; smart01043
326427009186	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
326427009187	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
326427009188	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
326427009189	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
326427009190	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
326427009191	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
326427009192	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
326427009193	Transcriptional regulator [Transcription]; Region: LysR; COG0583
326427009194	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
326427009195	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
326427009196	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
326427009197	NADH dehydrogenase subunit L; Provisional; Region: PRK08168
326427009198	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
326427009199	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
326427009200	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
326427009201	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
326427009202	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427009203	Walker A motif; other site
326427009204	ATP binding site [chemical binding]; other site
326427009205	Walker B motif; other site
326427009206	arginine finger; other site
326427009207	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
326427009208	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
326427009209	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
326427009210	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
326427009211	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
326427009212	active site
326427009213	phosphorylation site [posttranslational modification]
326427009214	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
326427009215	dimerization domain swap beta strand [polypeptide binding]; other site
326427009216	regulatory protein interface [polypeptide binding]; other site
326427009217	active site
326427009218	regulatory phosphorylation site [posttranslational modification]; other site
326427009219	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
326427009220	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
326427009221	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
326427009222	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
326427009223	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
326427009224	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
326427009225	putative substrate binding site [chemical binding]; other site
326427009226	putative ATP binding site [chemical binding]; other site
326427009227	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
326427009228	active site
326427009229	P-loop; other site
326427009230	phosphorylation site [posttranslational modification]
326427009231	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
326427009232	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
326427009233	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
326427009234	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
326427009235	catalytic loop [active]
326427009236	iron binding site [ion binding]; other site
326427009237	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
326427009238	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
326427009239	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
326427009240	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
326427009241	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
326427009242	P loop; other site
326427009243	GTP binding site [chemical binding]; other site
326427009244	lysine biosynthesis protein LysW; Region: lysW; TIGR01206
326427009245	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
326427009246	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
326427009247	TM-ABC transporter signature motif; other site
326427009248	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
326427009249	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
326427009250	Walker A/P-loop; other site
326427009251	ATP binding site [chemical binding]; other site
326427009252	Q-loop/lid; other site
326427009253	ABC transporter signature motif; other site
326427009254	Walker B; other site
326427009255	D-loop; other site
326427009256	H-loop/switch region; other site
326427009257	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
326427009258	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
326427009259	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
326427009260	ligand binding site [chemical binding]; other site
326427009261	dimerization interface [polypeptide binding]; other site
326427009262	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
326427009263	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
326427009264	TM-ABC transporter signature motif; other site
326427009265	D-ribose pyranase; Provisional; Region: PRK11797
326427009266	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
326427009267	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
326427009268	substrate binding site [chemical binding]; other site
326427009269	dimer interface [polypeptide binding]; other site
326427009270	ATP binding site [chemical binding]; other site
326427009271	Transcriptional regulators [Transcription]; Region: PurR; COG1609
326427009272	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
326427009273	DNA binding site [nucleotide binding]
326427009274	domain linker motif; other site
326427009275	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
326427009276	dimerization interface [polypeptide binding]; other site
326427009277	ligand binding site [chemical binding]; other site
326427009278	Peptidase family M50; Region: Peptidase_M50; pfam02163
326427009279	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
326427009280	active site
326427009281	putative substrate binding region [chemical binding]; other site
326427009282	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
326427009283	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326427009284	ligand binding site [chemical binding]; other site
326427009285	flexible hinge region; other site
326427009286	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
326427009287	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326427009288	ligand binding site [chemical binding]; other site
326427009289	flexible hinge region; other site
326427009290	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
326427009291	TIGR01777 family protein; Region: yfcH
326427009292	putative NAD(P) binding site [chemical binding]; other site
326427009293	putative active site [active]
326427009294	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
326427009295	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
326427009296	protein binding site [polypeptide binding]; other site
326427009297	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
326427009298	putative active site [active]
326427009299	putative CoA binding site [chemical binding]; other site
326427009300	nudix motif; other site
326427009301	metal binding site [ion binding]; metal-binding site
326427009302	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
326427009303	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
326427009304	inhibitor-cofactor binding pocket; inhibition site
326427009305	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427009306	catalytic residue [active]
326427009307	Pantoate-beta-alanine ligase; Region: PanC; cd00560
326427009308	pantoate--beta-alanine ligase; Region: panC; TIGR00018
326427009309	active site
326427009310	ATP-binding site [chemical binding]; other site
326427009311	pantoate-binding site; other site
326427009312	HXXH motif; other site
326427009313	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
326427009314	oligomerization interface [polypeptide binding]; other site
326427009315	active site
326427009316	metal binding site [ion binding]; metal-binding site
326427009317	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
326427009318	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
326427009319	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
326427009320	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
326427009321	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
326427009322	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
326427009323	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
326427009324	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
326427009325	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
326427009326	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
326427009327	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
326427009328	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
326427009329	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
326427009330	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
326427009331	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
326427009332	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
326427009333	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
326427009334	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
326427009335	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
326427009336	GAF domain; Region: GAF_2; pfam13185
326427009337	GAF domain; Region: GAF; cl17456
326427009338	GAF domain; Region: GAF; pfam01590
326427009339	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
326427009340	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
326427009341	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
326427009342	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427009343	S-adenosylmethionine binding site [chemical binding]; other site
326427009344	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
326427009345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427009346	active site
326427009347	phosphorylation site [posttranslational modification]
326427009348	intermolecular recognition site; other site
326427009349	dimerization interface [polypeptide binding]; other site
326427009350	ANTAR domain; Region: ANTAR; pfam03861
326427009351	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
326427009352	homotrimer interaction site [polypeptide binding]; other site
326427009353	active site
326427009354	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
326427009355	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
326427009356	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
326427009357	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
326427009358	active site
326427009359	multimer interface [polypeptide binding]; other site
326427009360	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
326427009361	predicted active site [active]
326427009362	catalytic triad [active]
326427009363	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
326427009364	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
326427009365	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427009366	Walker A motif; other site
326427009367	Walker A/P-loop; other site
326427009368	ATP binding site [chemical binding]; other site
326427009369	ATP binding site [chemical binding]; other site
326427009370	Walker B motif; other site
326427009371	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
326427009372	RxxxH motif; other site
326427009373	thymidylate kinase; Validated; Region: tmk; PRK00698
326427009374	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
326427009375	TMP-binding site; other site
326427009376	ATP-binding site [chemical binding]; other site
326427009377	Protein of unknown function (DUF970); Region: DUF970; pfam06153
326427009378	Arv1-like family; Region: Arv1; pfam04161
326427009379	Double zinc ribbon; Region: DZR; pfam12773
326427009380	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
326427009381	putative active site pocket [active]
326427009382	cleavage site
326427009383	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
326427009384	peptide binding site [polypeptide binding]; other site
326427009385	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
326427009386	dimer interface [polypeptide binding]; other site
326427009387	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
326427009388	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
326427009389	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
326427009390	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
326427009391	pyrroline-5-carboxylate reductase; Region: PLN02688
326427009392	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
326427009393	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
326427009394	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
326427009395	putative active site [active]
326427009396	putative metal binding site [ion binding]; other site
326427009397	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
326427009398	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
326427009399	chromosome segregation protein; Provisional; Region: PRK03918
326427009400	Walker A/P-loop; other site
326427009401	ATP binding site [chemical binding]; other site
326427009402	Q-loop/lid; other site
326427009403	ABC transporter signature motif; other site
326427009404	D-loop; other site
326427009405	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
326427009406	ABC transporter signature motif; other site
326427009407	Walker B; other site
326427009408	D-loop; other site
326427009409	H-loop/switch region; other site
326427009410	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
326427009411	Transcriptional regulator [Transcription]; Region: LysR; COG0583
326427009412	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
326427009413	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
326427009414	dimerization interface [polypeptide binding]; other site
326427009415	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
326427009416	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
326427009417	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
326427009418	nucleotide binding site [chemical binding]; other site
326427009419	NEF interaction site [polypeptide binding]; other site
326427009420	SBD interface [polypeptide binding]; other site
326427009421	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
326427009422	cyclase homology domain; Region: CHD; cd07302
326427009423	nucleotidyl binding site; other site
326427009424	metal binding site [ion binding]; metal-binding site
326427009425	dimer interface [polypeptide binding]; other site
326427009426	cyclase homology domain; Region: CHD; cd07302
326427009427	nucleotidyl binding site; other site
326427009428	metal binding site [ion binding]; metal-binding site
326427009429	dimer interface [polypeptide binding]; other site
326427009430	AAA ATPase domain; Region: AAA_16; pfam13191
326427009431	Predicted ATPase [General function prediction only]; Region: COG3899
326427009432	Walker A motif; other site
326427009433	ATP binding site [chemical binding]; other site
326427009434	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
326427009435	cyclase homology domain; Region: CHD; cd07302
326427009436	nucleotidyl binding site; other site
326427009437	metal binding site [ion binding]; metal-binding site
326427009438	dimer interface [polypeptide binding]; other site
326427009439	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427009440	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
326427009441	Protein of unknown function (DUF970); Region: DUF970; cl17525
326427009442	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
326427009443	active site
326427009444	Bacterial transcriptional activator domain; Region: BTAD; smart01043
326427009445	AAA ATPase domain; Region: AAA_16; pfam13191
326427009446	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326427009447	Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714
326427009448	active site
326427009449	ATP binding site [chemical binding]; other site
326427009450	substrate binding site [chemical binding]; other site
326427009451	activation loop (A-loop); other site
326427009452	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
326427009453	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
326427009454	Walker A/P-loop; other site
326427009455	ATP binding site [chemical binding]; other site
326427009456	Q-loop/lid; other site
326427009457	ABC transporter signature motif; other site
326427009458	Walker B; other site
326427009459	D-loop; other site
326427009460	H-loop/switch region; other site
326427009461	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
326427009462	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
326427009463	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
326427009464	Walker A/P-loop; other site
326427009465	ATP binding site [chemical binding]; other site
326427009466	Q-loop/lid; other site
326427009467	ABC transporter signature motif; other site
326427009468	Walker B; other site
326427009469	D-loop; other site
326427009470	H-loop/switch region; other site
326427009471	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
326427009472	ba3-like heme-copper oxidase subunit I.  The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660
326427009473	Putative D-pathway homolog; other site
326427009474	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
326427009475	Low-spin heme binding site [chemical binding]; other site
326427009476	Subunit I/II interface [polypeptide binding]; other site
326427009477	Putative Q-pathway; other site
326427009478	Putative alternate electron transfer pathway; other site
326427009479	Putative water exit pathway; other site
326427009480	Binuclear center (active site) [active]
326427009481	Putative K-pathway homolog; other site
326427009482	Putative proton exit pathway; other site
326427009483	Subunit I/IIa interface [polypeptide binding]; other site
326427009484	Electron transfer pathway; other site
326427009485	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
326427009486	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
326427009487	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
326427009488	Cu(I) binding site [ion binding]; other site
326427009489	phytoene desaturase; Region: crtI_fam; TIGR02734
326427009490	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
326427009491	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
326427009492	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
326427009493	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
326427009494	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
326427009495	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
326427009496	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
326427009497	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14338
326427009498	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
326427009499	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326427009500	FeS/SAM binding site; other site
326427009501	TRAM domain; Region: TRAM; pfam01938
326427009502	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427009503	binding surface
326427009504	Tetratricopeptide repeat; Region: TPR_16; pfam13432
326427009505	TPR motif; other site
326427009506	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427009507	Walker A motif; other site
326427009508	ATP binding site [chemical binding]; other site
326427009509	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
326427009510	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
326427009511	ATP binding site [chemical binding]; other site
326427009512	Walker A motif; other site
326427009513	hexamer interface [polypeptide binding]; other site
326427009514	Walker B motif; other site
326427009515	phytoene desaturase; Region: crtI_fam; TIGR02734
326427009516	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326427009517	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427009518	NAD(P) binding site [chemical binding]; other site
326427009519	active site
326427009520	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
326427009521	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427009522	NAD(P) binding site [chemical binding]; other site
326427009523	active site
326427009524	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
326427009525	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
326427009526	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
326427009527	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
326427009528	dimer interface [polypeptide binding]; other site
326427009529	active site
326427009530	CoA binding pocket [chemical binding]; other site
326427009531	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
326427009532	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
326427009533	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
326427009534	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
326427009535	active site
326427009536	(T/H)XGH motif; other site
326427009537	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
326427009538	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427009539	S-adenosylmethionine binding site [chemical binding]; other site
326427009540	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
326427009541	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
326427009542	23S rRNA interface [nucleotide binding]; other site
326427009543	L3 interface [polypeptide binding]; other site
326427009544	tRNA pseudouridine synthase ACD; Provisional; Region: PRK14588
326427009545	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
326427009546	dimerization interface 3.5A [polypeptide binding]; other site
326427009547	active site
326427009548	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
326427009549	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
326427009550	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
326427009551	alphaNTD homodimer interface [polypeptide binding]; other site
326427009552	alphaNTD - beta interaction site [polypeptide binding]; other site
326427009553	alphaNTD - beta' interaction site [polypeptide binding]; other site
326427009554	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
326427009555	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
326427009556	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
326427009557	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
326427009558	RNA binding surface [nucleotide binding]; other site
326427009559	30S ribosomal protein S11; Validated; Region: PRK05309
326427009560	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
326427009561	30S ribosomal protein S13; Region: bact_S13; TIGR03631
326427009562	Ribosomal protein L36 [Translation, ribosomal structure and biogenesis]; Region: RpmJ; COG0257
326427009563	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
326427009564	rRNA binding site [nucleotide binding]; other site
326427009565	predicted 30S ribosome binding site; other site
326427009566	adenylate kinase; Reviewed; Region: adk; PRK00279
326427009567	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
326427009568	AMP-binding site [chemical binding]; other site
326427009569	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
326427009570	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
326427009571	SecY translocase; Region: SecY; pfam00344
326427009572	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
326427009573	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
326427009574	23S rRNA binding site [nucleotide binding]; other site
326427009575	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
326427009576	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
326427009577	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
326427009578	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
326427009579	23S rRNA interface [nucleotide binding]; other site
326427009580	5S rRNA interface [nucleotide binding]; other site
326427009581	L27 interface [polypeptide binding]; other site
326427009582	L5 interface [polypeptide binding]; other site
326427009583	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
326427009584	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
326427009585	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
326427009586	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
326427009587	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
326427009588	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
326427009589	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
326427009590	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
326427009591	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
326427009592	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
326427009593	RNA binding site [nucleotide binding]; other site
326427009594	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
326427009595	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
326427009596	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
326427009597	23S rRNA interface [nucleotide binding]; other site
326427009598	putative translocon interaction site; other site
326427009599	signal recognition particle (SRP54) interaction site; other site
326427009600	L23 interface [polypeptide binding]; other site
326427009601	trigger factor interaction site; other site
326427009602	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
326427009603	23S rRNA interface [nucleotide binding]; other site
326427009604	5S rRNA interface [nucleotide binding]; other site
326427009605	putative antibiotic binding site [chemical binding]; other site
326427009606	L25 interface [polypeptide binding]; other site
326427009607	L27 interface [polypeptide binding]; other site
326427009608	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
326427009609	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
326427009610	G-X-X-G motif; other site
326427009611	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
326427009612	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
326427009613	putative translocon binding site; other site
326427009614	protein-rRNA interface [nucleotide binding]; other site
326427009615	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
326427009616	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
326427009617	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
326427009618	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
326427009619	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
326427009620	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
326427009621	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
326427009622	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
326427009623	elongation factor Tu; Reviewed; Region: PRK00049
326427009624	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
326427009625	G1 box; other site
326427009626	GEF interaction site [polypeptide binding]; other site
326427009627	GTP/Mg2+ binding site [chemical binding]; other site
326427009628	Switch I region; other site
326427009629	G2 box; other site
326427009630	G3 box; other site
326427009631	Switch II region; other site
326427009632	G4 box; other site
326427009633	G5 box; other site
326427009634	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
326427009635	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
326427009636	Antibiotic Binding Site [chemical binding]; other site
326427009637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427009638	S-adenosylmethionine binding site [chemical binding]; other site
326427009639	elongation factor G; Reviewed; Region: PRK00007
326427009640	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
326427009641	G1 box; other site
326427009642	putative GEF interaction site [polypeptide binding]; other site
326427009643	GTP/Mg2+ binding site [chemical binding]; other site
326427009644	Switch I region; other site
326427009645	G2 box; other site
326427009646	G3 box; other site
326427009647	Switch II region; other site
326427009648	G4 box; other site
326427009649	G5 box; other site
326427009650	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
326427009651	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
326427009652	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
326427009653	30S ribosomal protein S7; Validated; Region: PRK05302
326427009654	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
326427009655	16S rRNA interaction site [nucleotide binding]; other site
326427009656	streptomycin interaction site [chemical binding]; other site
326427009657	23S rRNA interaction site [nucleotide binding]; other site
326427009658	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
326427009659	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
326427009660	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
326427009661	Probable transposase; Region: OrfB_IS605; pfam01385
326427009662	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326427009663	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
326427009664	ATP binding site [chemical binding]; other site
326427009665	Mg2+ binding site [ion binding]; other site
326427009666	G-X-G motif; other site
326427009667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
326427009668	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
326427009669	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
326427009670	anti sigma factor interaction site; other site
326427009671	regulatory phosphorylation site [posttranslational modification]; other site
326427009672	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
326427009673	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
326427009674	putative ribose interaction site [chemical binding]; other site
326427009675	putative ADP binding site [chemical binding]; other site
326427009676	aspartate aminotransferase; Provisional; Region: PRK05764
326427009677	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326427009678	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427009679	homodimer interface [polypeptide binding]; other site
326427009680	catalytic residue [active]
326427009681	phytoene desaturase; Region: phytoene_desat; TIGR02731
326427009682	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
326427009683	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
326427009684	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
326427009685	active site
326427009686	ATP binding site [chemical binding]; other site
326427009687	substrate binding site [chemical binding]; other site
326427009688	activation loop (A-loop); other site
326427009689	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326427009690	structural tetrad; other site
326427009691	PQQ-like domain; Region: PQQ_2; pfam13360
326427009692	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
326427009693	structural tetrad; other site
326427009694	FOG: WD40 repeat [General function prediction only]; Region: COG2319
326427009695	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
326427009696	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
326427009697	homodimer interface [polypeptide binding]; other site
326427009698	active site
326427009699	TDP-binding site; other site
326427009700	acceptor substrate-binding pocket; other site
326427009701	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
326427009702	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
326427009703	[2Fe-2S] cluster binding site [ion binding]; other site
326427009704	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
326427009705	putative alpha subunit interface [polypeptide binding]; other site
326427009706	putative active site [active]
326427009707	putative substrate binding site [chemical binding]; other site
326427009708	Fe binding site [ion binding]; other site
326427009709	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
326427009710	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
326427009711	Moco binding site; other site
326427009712	metal coordination site [ion binding]; other site
326427009713	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
326427009714	Active_site [active]
326427009715	Lamin Tail Domain; Region: LTD; pfam00932
326427009716	Lamin Tail Domain; Region: LTD; pfam00932
326427009717	Lamin Tail Domain; Region: LTD; pfam00932
326427009718	Lamin Tail Domain; Region: LTD; pfam00932
326427009719	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
326427009720	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
326427009721	nucleotide binding site [chemical binding]; other site
326427009722	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
326427009723	HEAT repeats; Region: HEAT_2; pfam13646
326427009724	HEAT repeats; Region: HEAT_2; pfam13646
326427009725	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
326427009726	FemAB family; Region: FemAB; pfam02388
326427009727	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
326427009728	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
326427009729	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
326427009730	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
326427009731	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
326427009732	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
326427009733	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
326427009734	phosphate binding site [ion binding]; other site
326427009735	FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192
326427009736	FAD binding pocket [chemical binding]; other site
326427009737	FAD binding motif [chemical binding]; other site
326427009738	phosphate binding motif [ion binding]; other site
326427009739	beta-alpha-beta structure motif; other site
326427009740	NAD binding pocket [chemical binding]; other site
326427009741	Iron coordination center [ion binding]; other site
326427009742	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
326427009743	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
326427009744	peptide binding site [polypeptide binding]; other site
326427009745	dimer interface [polypeptide binding]; other site
326427009746	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
326427009747	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
326427009748	active site
326427009749	substrate-binding site [chemical binding]; other site
326427009750	metal-binding site [ion binding]
326427009751	GTP binding site [chemical binding]; other site
326427009752	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
326427009753	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
326427009754	DctM-like transporters; Region: DctM; pfam06808
326427009755	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
326427009756	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
326427009757	Predicted permeases [General function prediction only]; Region: COG0679
326427009758	Response regulator receiver domain; Region: Response_reg; pfam00072
326427009759	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427009760	active site
326427009761	phosphorylation site [posttranslational modification]
326427009762	intermolecular recognition site; other site
326427009763	dimerization interface [polypeptide binding]; other site
326427009764	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
326427009765	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
326427009766	active site
326427009767	NTP binding site [chemical binding]; other site
326427009768	metal binding triad [ion binding]; metal-binding site
326427009769	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
326427009770	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
326427009771	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
326427009772	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
326427009773	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
326427009774	active site
326427009775	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
326427009776	substrate binding pocket [chemical binding]; other site
326427009777	substrate-Mg2+ binding site; other site
326427009778	aspartate-rich region 1; other site
326427009779	aspartate-rich region 2; other site
326427009780	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
326427009781	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
326427009782	dimer interface [polypeptide binding]; other site
326427009783	anticodon binding site; other site
326427009784	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
326427009785	homodimer interface [polypeptide binding]; other site
326427009786	motif 1; other site
326427009787	active site
326427009788	motif 2; other site
326427009789	GAD domain; Region: GAD; pfam02938
326427009790	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
326427009791	active site
326427009792	motif 3; other site
326427009793	Response regulator receiver domain; Region: Response_reg; pfam00072
326427009794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427009795	active site
326427009796	phosphorylation site [posttranslational modification]
326427009797	intermolecular recognition site; other site
326427009798	dimerization interface [polypeptide binding]; other site
326427009799	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
326427009800	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
326427009801	Ribosomal protein L31; Region: Ribosomal_L31; pfam01197
326427009802	HTH domain; Region: HTH_11; pfam08279
326427009803	Predicted transcriptional regulator [Transcription]; Region: COG2378
326427009804	WYL domain; Region: WYL; pfam13280
326427009805	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
326427009806	ATP-grasp domain; Region: ATP-grasp; pfam02222
326427009807	AIR carboxylase; Region: AIRC; pfam00731
326427009808	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
326427009809	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
326427009810	NAD binding site [chemical binding]; other site
326427009811	substrate binding site [chemical binding]; other site
326427009812	homodimer interface [polypeptide binding]; other site
326427009813	active site
326427009814	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
326427009815	thymidine kinase; Provisional; Region: PRK04296
326427009816	phage shock protein A; Region: phageshock_pspA; TIGR02977
326427009817	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
326427009818	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427009819	S-adenosylmethionine binding site [chemical binding]; other site
326427009820	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
326427009821	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
326427009822	active site
326427009823	(T/H)XGH motif; other site
326427009824	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
326427009825	Isochorismatase family; Region: Isochorismatase; pfam00857
326427009826	N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015
326427009827	catalytic triad [active]
326427009828	substrate binding site [chemical binding]; other site
326427009829	domain interfaces; other site
326427009830	conserved cis-peptide bond; other site
326427009831	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
326427009832	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
326427009833	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
326427009834	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
326427009835	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
326427009836	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
326427009837	active site
326427009838	catalytic residues [active]
326427009839	metal binding site [ion binding]; metal-binding site
326427009840	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326427009841	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326427009842	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
326427009843	DNA-binding site [nucleotide binding]; DNA binding site
326427009844	Transcriptional regulators [Transcription]; Region: GntR; COG1802
326427009845	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
326427009846	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
326427009847	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
326427009848	Probable Catalytic site; other site
326427009849	metal-binding site
326427009850	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
326427009851	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
326427009852	HflX GTPase family; Region: HflX; cd01878
326427009853	G1 box; other site
326427009854	GTP/Mg2+ binding site [chemical binding]; other site
326427009855	Switch I region; other site
326427009856	G2 box; other site
326427009857	G3 box; other site
326427009858	Switch II region; other site
326427009859	G4 box; other site
326427009860	G5 box; other site
326427009861	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
326427009862	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
326427009863	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
326427009864	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
326427009865	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
326427009866	Peptidase family M23; Region: Peptidase_M23; pfam01551
326427009867	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
326427009868	NurA domain; Region: NurA; pfam09376
326427009869	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
326427009870	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
326427009871	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
326427009872	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
326427009873	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
326427009874	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427009875	homodimer interface [polypeptide binding]; other site
326427009876	catalytic residue [active]
326427009877	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
326427009878	active site
326427009879	catalytic site [active]
326427009880	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
326427009881	Membrane protein of unknown function; Region: DUF360; pfam04020
326427009882	Methyltransferase domain; Region: Methyltransf_23; pfam13489
326427009883	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427009884	S-adenosylmethionine binding site [chemical binding]; other site
326427009885	Domain of unknown function DUF77; Region: DUF77; pfam01910
326427009886	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
326427009887	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427009888	dimer interface [polypeptide binding]; other site
326427009889	conserved gate region; other site
326427009890	putative PBP binding loops; other site
326427009891	ABC-ATPase subunit interface; other site
326427009892	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
326427009893	NMT1/THI5 like; Region: NMT1; pfam09084
326427009894	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
326427009895	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
326427009896	Walker A/P-loop; other site
326427009897	ATP binding site [chemical binding]; other site
326427009898	Q-loop/lid; other site
326427009899	ABC transporter signature motif; other site
326427009900	Walker B; other site
326427009901	D-loop; other site
326427009902	H-loop/switch region; other site
326427009903	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
326427009904	hydroxyglutarate oxidase; Provisional; Region: PRK11728
326427009905	recombination factor protein RarA; Reviewed; Region: PRK13342
326427009906	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427009907	Walker A motif; other site
326427009908	ATP binding site [chemical binding]; other site
326427009909	Walker B motif; other site
326427009910	arginine finger; other site
326427009911	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
326427009912	magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031
326427009913	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
326427009914	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
326427009915	metal ion-dependent adhesion site (MIDAS); other site
326427009916	magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030
326427009917	Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596
326427009918	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
326427009919	chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
326427009920	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
326427009921	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
326427009922	putative NAD(P) binding site [chemical binding]; other site
326427009923	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
326427009924	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427009925	S-adenosylmethionine binding site [chemical binding]; other site
326427009926	PUCC protein; Region: PUCC; pfam03209
326427009927	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
326427009928	putative substrate translocation pore; other site
326427009929	Domain of unknown function DUF11; Region: DUF11; pfam01345
326427009930	Domain of unknown function DUF11; Region: DUF11; pfam01345
326427009931	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009932	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009933	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009934	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009935	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009936	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009937	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009938	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009939	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009940	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
326427009941	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009942	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009943	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009944	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009945	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
326427009946	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009947	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009948	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009949	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009950	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009951	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009952	Cna protein B-type domain; Region: Cna_B; pfam05738
326427009953	Response regulator receiver domain; Region: Response_reg; pfam00072
326427009954	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427009955	active site
326427009956	phosphorylation site [posttranslational modification]
326427009957	intermolecular recognition site; other site
326427009958	dimerization interface [polypeptide binding]; other site
326427009959	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
326427009960	PAS domain; Region: PAS; smart00091
326427009961	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427009962	dimer interface [polypeptide binding]; other site
326427009963	phosphorylation site [posttranslational modification]
326427009964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427009965	ATP binding site [chemical binding]; other site
326427009966	Mg2+ binding site [ion binding]; other site
326427009967	G-X-G motif; other site
326427009968	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
326427009969	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
326427009970	NADP binding site [chemical binding]; other site
326427009971	active site
326427009972	putative substrate binding site [chemical binding]; other site
326427009973	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
326427009974	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
326427009975	Probable Catalytic site; other site
326427009976	metal-binding site
326427009977	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
326427009978	Ligand binding site; other site
326427009979	Ligand binding site; other site
326427009980	Ligand binding site; other site
326427009981	Putative Catalytic site; other site
326427009982	DXD motif; other site
326427009983	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
326427009984	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
326427009985	MASE1; Region: MASE1; cl17823
326427009986	CHASE domain; Region: CHASE; pfam03924
326427009987	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427009988	GAF domain; Region: GAF; pfam01590
326427009989	PAS fold; Region: PAS_4; pfam08448
326427009990	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427009991	dimer interface [polypeptide binding]; other site
326427009992	phosphorylation site [posttranslational modification]
326427009993	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427009994	ATP binding site [chemical binding]; other site
326427009995	Mg2+ binding site [ion binding]; other site
326427009996	G-X-G motif; other site
326427009997	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427009998	Response regulator receiver domain; Region: Response_reg; pfam00072
326427009999	active site
326427010000	phosphorylation site [posttranslational modification]
326427010001	intermolecular recognition site; other site
326427010002	dimerization interface [polypeptide binding]; other site
326427010003	Response regulator receiver domain; Region: Response_reg; pfam00072
326427010004	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427010005	active site
326427010006	phosphorylation site [posttranslational modification]
326427010007	intermolecular recognition site; other site
326427010008	dimerization interface [polypeptide binding]; other site
326427010009	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
326427010010	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326427010011	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326427010012	DNA binding residues [nucleotide binding]
326427010013	Haemolytic domain; Region: Haemolytic; pfam01809
326427010014	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
326427010015	MPT binding site; other site
326427010016	trimer interface [polypeptide binding]; other site
326427010017	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
326427010018	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
326427010019	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
326427010020	Dehydroquinase class II; Region: DHquinase_II; pfam01220
326427010021	trimer interface [polypeptide binding]; other site
326427010022	active site
326427010023	dimer interface [polypeptide binding]; other site
326427010024	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
326427010025	Right handed beta helix region; Region: Beta_helix; pfam13229
326427010026	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
326427010027	Right handed beta helix region; Region: Beta_helix; pfam13229
326427010028	Right handed beta helix region; Region: Beta_helix; pfam13229
326427010029	Right handed beta helix region; Region: Beta_helix; pfam13229
326427010030	Transposase IS200 like; Region: Y1_Tnp; pfam01797
326427010031	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
326427010032	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
326427010033	Probable transposase; Region: OrfB_IS605; pfam01385
326427010034	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
326427010035	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
326427010036	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
326427010037	EamA-like transporter family; Region: EamA; pfam00892
326427010038	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
326427010039	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
326427010040	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
326427010041	dimer interface [polypeptide binding]; other site
326427010042	motif 1; other site
326427010043	active site
326427010044	motif 2; other site
326427010045	motif 3; other site
326427010046	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
326427010047	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
326427010048	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
326427010049	23S rRNA binding site [nucleotide binding]; other site
326427010050	L21 binding site [polypeptide binding]; other site
326427010051	L13 binding site [polypeptide binding]; other site
326427010052	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
326427010053	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
326427010054	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
326427010055	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
326427010056	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
326427010057	substrate binding site [chemical binding]; other site
326427010058	multimerization interface [polypeptide binding]; other site
326427010059	ATP binding site [chemical binding]; other site
326427010060	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
326427010061	thiamine phosphate binding site [chemical binding]; other site
326427010062	active site
326427010063	pyrophosphate binding site [ion binding]; other site
326427010064	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
326427010065	dimer interface [polypeptide binding]; other site
326427010066	substrate binding site [chemical binding]; other site
326427010067	ATP binding site [chemical binding]; other site
326427010068	short chain dehydrogenase; Provisional; Region: PRK08267
326427010069	classical (c) SDRs; Region: SDR_c; cd05233
326427010070	NAD(P) binding site [chemical binding]; other site
326427010071	active site
326427010072	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110
326427010073	hypothetical protein; Provisional; Region: PRK07233
326427010074	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
326427010075	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
326427010076	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
326427010077	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
326427010078	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
326427010079	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
326427010080	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
326427010081	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
326427010082	TM-ABC transporter signature motif; other site
326427010083	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
326427010084	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
326427010085	Walker A/P-loop; other site
326427010086	ATP binding site [chemical binding]; other site
326427010087	Q-loop/lid; other site
326427010088	ABC transporter signature motif; other site
326427010089	Walker B; other site
326427010090	D-loop; other site
326427010091	H-loop/switch region; other site
326427010092	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
326427010093	adenosine deaminase; Provisional; Region: PRK09358
326427010094	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
326427010095	active site
326427010096	peptide chain release factor 1; Validated; Region: prfA; PRK00591
326427010097	This domain is found in peptide chain release factors; Region: PCRF; smart00937
326427010098	RF-1 domain; Region: RF-1; pfam00472
326427010099	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
326427010100	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
326427010101	active site
326427010102	homodimer interface [polypeptide binding]; other site
326427010103	catalytic site [active]
326427010104	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
326427010105	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326427010106	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427010107	dimer interface [polypeptide binding]; other site
326427010108	conserved gate region; other site
326427010109	putative PBP binding loops; other site
326427010110	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
326427010111	ABC-ATPase subunit interface; other site
326427010112	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
326427010113	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427010114	dimer interface [polypeptide binding]; other site
326427010115	conserved gate region; other site
326427010116	putative PBP binding loops; other site
326427010117	ABC-ATPase subunit interface; other site
326427010118	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
326427010119	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
326427010120	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326427010121	MarR family; Region: MarR_2; pfam12802
326427010122	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
326427010123	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
326427010124	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
326427010125	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
326427010126	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
326427010127	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
326427010128	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
326427010129	Probable transposase; Region: OrfB_IS605; pfam01385
326427010130	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
326427010131	Transposase IS200 like; Region: Y1_Tnp; pfam01797
326427010132	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
326427010133	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
326427010134	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
326427010135	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
326427010136	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
326427010137	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
326427010138	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
326427010139	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
326427010140	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
326427010141	nucleotide binding region [chemical binding]; other site
326427010142	SEC-C motif; Region: SEC-C; pfam02810
326427010143	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
326427010144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427010145	active site
326427010146	phosphorylation site [posttranslational modification]
326427010147	intermolecular recognition site; other site
326427010148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
326427010149	active site
326427010150	phosphorylation site [posttranslational modification]
326427010151	intermolecular recognition site; other site
326427010152	PAS domain; Region: PAS_9; pfam13426
326427010153	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427010154	putative active site [active]
326427010155	heme pocket [chemical binding]; other site
326427010156	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427010157	GAF domain; Region: GAF_3; pfam13492
326427010158	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
326427010159	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
326427010160	Zn2+ binding site [ion binding]; other site
326427010161	Mg2+ binding site [ion binding]; other site
326427010162	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326427010163	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427010164	dimer interface [polypeptide binding]; other site
326427010165	phosphorylation site [posttranslational modification]
326427010166	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427010167	ATP binding site [chemical binding]; other site
326427010168	Mg2+ binding site [ion binding]; other site
326427010169	G-X-G motif; other site
326427010170	VPS10 domain; Region: VPS10; smart00602
326427010171	AAA domain; Region: AAA_22; pfam13401
326427010172	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
326427010173	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950
326427010174	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427010175	Walker A motif; other site
326427010176	ATP binding site [chemical binding]; other site
326427010177	Walker B motif; other site
326427010178	arginine finger; other site
326427010179	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
326427010180	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
326427010181	hypothetical protein; Provisional; Region: PRK14627
326427010182	recombination protein RecR; Reviewed; Region: recR; PRK00076
326427010183	RecR protein; Region: RecR; pfam02132
326427010184	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
326427010185	putative active site [active]
326427010186	putative metal-binding site [ion binding]; other site
326427010187	tetramer interface [polypeptide binding]; other site
326427010188	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
326427010189	HipA-like N-terminal domain; Region: HipA_N; pfam07805
326427010190	trehalose synthase; Region: treS_nterm; TIGR02456
326427010191	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316
326427010192	Ca binding site [ion binding]; other site
326427010193	active site
326427010194	catalytic site [active]
326427010195	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
326427010196	ligand binding site [chemical binding]; other site
326427010197	active site
326427010198	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
326427010199	TAP-like protein; Region: Abhydrolase_4; pfam08386
326427010200	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
326427010201	Response regulator receiver domain; Region: Response_reg; pfam00072
326427010202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427010203	active site
326427010204	phosphorylation site [posttranslational modification]
326427010205	intermolecular recognition site; other site
326427010206	dimerization interface [polypeptide binding]; other site
326427010207	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
326427010208	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
326427010209	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
326427010210	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
326427010211	ATP binding site [chemical binding]; other site
326427010212	Walker A motif; other site
326427010213	hexamer interface [polypeptide binding]; other site
326427010214	Walker B motif; other site
326427010215	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
326427010216	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
326427010217	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
326427010218	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
326427010219	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
326427010220	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
326427010221	AAK_FomA-like: This CD includes a fosfomycin biosynthetic gene product, FomA, and similar proteins found in a wide range of organisms. Together, the fomA and fomB genes in the fosfomycin biosynthetic gene cluster of Streptomyces wedmorensis confer...; Region: AAK_FomA-like; cd04241
326427010222	putative nucleotide binding site [chemical binding]; other site
326427010223	putative substrate binding site [chemical binding]; other site
326427010224	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
326427010225	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
326427010226	active site
326427010227	dimerization interface [polypeptide binding]; other site
326427010228	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
326427010229	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
326427010230	homodimer interface [polypeptide binding]; other site
326427010231	substrate-cofactor binding pocket; other site
326427010232	catalytic residue [active]
326427010233	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
326427010234	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
326427010235	Walker A/P-loop; other site
326427010236	ATP binding site [chemical binding]; other site
326427010237	Q-loop/lid; other site
326427010238	ABC transporter signature motif; other site
326427010239	Walker B; other site
326427010240	D-loop; other site
326427010241	H-loop/switch region; other site
326427010242	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326427010243	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326427010244	active site
326427010245	ATP binding site [chemical binding]; other site
326427010246	substrate binding site [chemical binding]; other site
326427010247	activation loop (A-loop); other site
326427010248	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
326427010249	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
326427010250	RNase_H superfamily; Region: RNase_H_2; pfam13482
326427010251	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
326427010252	active site
326427010253	tetramer interface [polypeptide binding]; other site
326427010254	integral membrane protein MviN; Region: mviN; TIGR01695
326427010255	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
326427010256	Transcriptional regulator [Transcription]; Region: LytR; COG1316
326427010257	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
326427010258	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
326427010259	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
326427010260	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
326427010261	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
326427010262	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
326427010263	Walker A/P-loop; other site
326427010264	ATP binding site [chemical binding]; other site
326427010265	Q-loop/lid; other site
326427010266	ABC transporter signature motif; other site
326427010267	Walker B; other site
326427010268	D-loop; other site
326427010269	H-loop/switch region; other site
326427010270	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
326427010271	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
326427010272	LexA repressor; Validated; Region: PRK00215
326427010273	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
326427010274	Catalytic site [active]
326427010275	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
326427010276	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
326427010277	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
326427010278	putative substrate binding site [chemical binding]; other site
326427010279	putative ATP binding site [chemical binding]; other site
326427010280	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
326427010281	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
326427010282	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
326427010283	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
326427010284	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
326427010285	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
326427010286	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
326427010287	P loop; other site
326427010288	Nucleotide binding site [chemical binding]; other site
326427010289	DTAP/Switch II; other site
326427010290	Switch I; other site
326427010291	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
326427010292	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
326427010293	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
326427010294	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
326427010295	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
326427010296	glutaminase active site [active]
326427010297	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
326427010298	dimer interface [polypeptide binding]; other site
326427010299	active site
326427010300	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
326427010301	dimer interface [polypeptide binding]; other site
326427010302	active site
326427010303	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
326427010304	GAF domain; Region: GAF; pfam01590
326427010305	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427010306	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427010307	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
326427010308	putative active site [active]
326427010309	heme pocket [chemical binding]; other site
326427010310	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427010311	dimer interface [polypeptide binding]; other site
326427010312	phosphorylation site [posttranslational modification]
326427010313	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427010314	ATP binding site [chemical binding]; other site
326427010315	Mg2+ binding site [ion binding]; other site
326427010316	G-X-G motif; other site
326427010317	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
326427010318	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427010319	active site
326427010320	phosphorylation site [posttranslational modification]
326427010321	intermolecular recognition site; other site
326427010322	dimerization interface [polypeptide binding]; other site
326427010323	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
326427010324	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
326427010325	VanW like protein; Region: VanW; pfam04294
326427010326	glutamate racemase; Provisional; Region: PRK00865
326427010327	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
326427010328	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
326427010329	catalytic triad [active]
326427010330	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
326427010331	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
326427010332	catalytic triad [active]
326427010333	GAF domain; Region: GAF_3; pfam13492
326427010334	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427010335	GAF domain; Region: GAF_2; pfam13185
326427010336	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
326427010337	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427010338	putative active site [active]
326427010339	heme pocket [chemical binding]; other site
326427010340	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427010341	dimer interface [polypeptide binding]; other site
326427010342	phosphorylation site [posttranslational modification]
326427010343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427010344	ATP binding site [chemical binding]; other site
326427010345	Mg2+ binding site [ion binding]; other site
326427010346	G-X-G motif; other site
326427010347	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
326427010348	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
326427010349	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427010350	ATP binding site [chemical binding]; other site
326427010351	Mg2+ binding site [ion binding]; other site
326427010352	G-X-G motif; other site
326427010353	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
326427010354	putative active site [active]
326427010355	dimerization interface [polypeptide binding]; other site
326427010356	putative tRNAtyr binding site [nucleotide binding]; other site
326427010357	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
326427010358	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
326427010359	putative active site [active]
326427010360	DNA repair protein RadA; Provisional; Region: PRK11823
326427010361	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
326427010362	Walker A motif/ATP binding site; other site
326427010363	ATP binding site [chemical binding]; other site
326427010364	Walker B motif; other site
326427010365	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
326427010366	O-Antigen ligase; Region: Wzy_C; pfam04932
326427010367	Methyltransferase domain; Region: Methyltransf_23; pfam13489
326427010368	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427010369	S-adenosylmethionine binding site [chemical binding]; other site
326427010370	HNH endonuclease; Region: HNH_4; pfam13395
326427010371	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
326427010372	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
326427010373	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
326427010374	Walker A/P-loop; other site
326427010375	ATP binding site [chemical binding]; other site
326427010376	Q-loop/lid; other site
326427010377	ABC transporter signature motif; other site
326427010378	Walker B; other site
326427010379	D-loop; other site
326427010380	H-loop/switch region; other site
326427010381	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
326427010382	putative active site [active]
326427010383	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326427010384	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427010385	active site
326427010386	phosphorylation site [posttranslational modification]
326427010387	intermolecular recognition site; other site
326427010388	dimerization interface [polypeptide binding]; other site
326427010389	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326427010390	DNA binding site [nucleotide binding]
326427010391	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
326427010392	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326427010393	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326427010394	dimerization interface [polypeptide binding]; other site
326427010395	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427010396	dimer interface [polypeptide binding]; other site
326427010397	phosphorylation site [posttranslational modification]
326427010398	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427010399	ATP binding site [chemical binding]; other site
326427010400	Mg2+ binding site [ion binding]; other site
326427010401	G-X-G motif; other site
326427010402	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
326427010403	MarR family; Region: MarR_2; pfam12802
326427010404	MarR family; Region: MarR_2; cl17246
326427010405	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
326427010406	Protoglobin; Region: Protoglobin; pfam11563
326427010407	DsrE/DsrF-like family; Region: DrsE; cl00672
326427010408	Methyltransferase domain; Region: Methyltransf_23; pfam13489
326427010409	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427010410	S-adenosylmethionine binding site [chemical binding]; other site
326427010411	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
326427010412	PA14 domain; Region: PA14; cl08459
326427010413	Mo-co oxidoreductase dimerisation domain; Region: Mo-co_dimer; pfam03404
326427010414	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
326427010415	Transposase IS200 like; Region: Y1_Tnp; pfam01797
326427010416	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
326427010417	Bacterial transcriptional activator domain; Region: BTAD; smart01043
326427010418	Predicted ATPase [General function prediction only]; Region: COG3903
326427010419	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427010420	binding surface
326427010421	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427010422	TPR motif; other site
326427010423	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427010424	Transposase; Region: DEDD_Tnp_IS110; pfam01548
326427010425	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
326427010426	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
326427010427	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
326427010428	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
326427010429	Uncharacterized conserved protein [Function unknown]; Region: COG2361
326427010430	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
326427010431	active site
326427010432	NTP binding site [chemical binding]; other site
326427010433	metal binding triad [ion binding]; metal-binding site
326427010434	antibiotic binding site [chemical binding]; other site
326427010435	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
326427010436	HsdM N-terminal domain; Region: HsdM_N; pfam12161
326427010437	Methyltransferase domain; Region: Methyltransf_26; pfam13659
326427010438	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326427010439	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427010440	active site
326427010441	phosphorylation site [posttranslational modification]
326427010442	intermolecular recognition site; other site
326427010443	dimerization interface [polypeptide binding]; other site
326427010444	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326427010445	DNA binding site [nucleotide binding]
326427010446	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326427010447	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326427010448	dimerization interface [polypeptide binding]; other site
326427010449	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427010450	dimer interface [polypeptide binding]; other site
326427010451	phosphorylation site [posttranslational modification]
326427010452	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427010453	ATP binding site [chemical binding]; other site
326427010454	Mg2+ binding site [ion binding]; other site
326427010455	G-X-G motif; other site
326427010456	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
326427010457	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
326427010458	FeoA domain; Region: FeoA; pfam04023
326427010459	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
326427010460	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
326427010461	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
326427010462	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
326427010463	ABC-ATPase subunit  interface; other site
326427010464	dimer interface [polypeptide binding]; other site
326427010465	putative PBP binding regions; other site
326427010466	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
326427010467	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
326427010468	putative hemin binding site; other site
326427010469	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
326427010470	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
326427010471	Walker A/P-loop; other site
326427010472	ATP binding site [chemical binding]; other site
326427010473	Q-loop/lid; other site
326427010474	ABC transporter signature motif; other site
326427010475	Walker B; other site
326427010476	D-loop; other site
326427010477	H-loop/switch region; other site
326427010478	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
326427010479	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
326427010480	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
326427010481	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
326427010482	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
326427010483	Walker A/P-loop; other site
326427010484	ATP binding site [chemical binding]; other site
326427010485	Q-loop/lid; other site
326427010486	ABC transporter signature motif; other site
326427010487	Walker B; other site
326427010488	D-loop; other site
326427010489	H-loop/switch region; other site
326427010490	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
326427010491	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
326427010492	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
326427010493	TM-ABC transporter signature motif; other site
326427010494	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
326427010495	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
326427010496	TM-ABC transporter signature motif; other site
326427010497	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
326427010498	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
326427010499	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
326427010500	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
326427010501	Domain of unknown function (DUF718); Region: DUF718; pfam05336
326427010502	L-rhamnose isomerase; Provisional; Region: PRK01076
326427010503	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
326427010504	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase; Region: RhaD_aldol-ADH; TIGR02632
326427010505	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
326427010506	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427010507	NAD(P) binding site [chemical binding]; other site
326427010508	active site
326427010509	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
326427010510	N- and C-terminal domain interface [polypeptide binding]; other site
326427010511	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
326427010512	active site
326427010513	putative catalytic site [active]
326427010514	metal binding site [ion binding]; metal-binding site
326427010515	ATP binding site [chemical binding]; other site
326427010516	carbohydrate binding site [chemical binding]; other site
326427010517	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
326427010518	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
326427010519	Fe-S protein assembly chaperone HscA; Region: HscA; TIGR01991
326427010520	Transposase IS200 like; Region: Y1_Tnp; cl00848
326427010521	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
326427010522	N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178
326427010523	putative homodimer interface [polypeptide binding]; other site
326427010524	putative active site [active]
326427010525	catalytic site [active]
326427010526	PLD-like domain; Region: PLDc_2; pfam13091
326427010527	DEAD-like helicases superfamily; Region: DEXDc; smart00487
326427010528	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326427010529	putative Mg++ binding site [ion binding]; other site
326427010530	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
326427010531	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326427010532	nucleotide binding region [chemical binding]; other site
326427010533	ATP-binding site [chemical binding]; other site
326427010534	putative alpha-glucosidase; Provisional; Region: PRK10658
326427010535	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
326427010536	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
326427010537	trimer interface [polypeptide binding]; other site
326427010538	active site
326427010539	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
326427010540	catalytic site [active]
326427010541	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
326427010542	catalytic residues [active]
326427010543	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cd00562
326427010544	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
326427010545	adhesin; Provisional; Region: PRK09752
326427010546	prolyl-tRNA synthetase, family II; Region: proS_fam_II; TIGR00409
326427010547	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
326427010548	motif 1; other site
326427010549	dimer interface [polypeptide binding]; other site
326427010550	motif 2; other site
326427010551	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
326427010552	putative deacylase active site [active]
326427010553	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
326427010554	anticodon binding site; other site
326427010555	Protein of unknown function DUF72; Region: DUF72; pfam01904
326427010556	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
326427010557	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
326427010558	Glutamate binding site [chemical binding]; other site
326427010559	homodimer interface [polypeptide binding]; other site
326427010560	NAD binding site [chemical binding]; other site
326427010561	catalytic residues [active]
326427010562	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
326427010563	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427010564	S-adenosylmethionine binding site [chemical binding]; other site
326427010565	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
326427010566	DNA methylase; Region: N6_N4_Mtase; pfam01555
326427010567	HEAT repeats; Region: HEAT_2; pfam13646
326427010568	Type II restriction enzyme SfiI; Region: RestrictionSfiI; pfam11487
326427010569	DNA methylase; Region: N6_N4_Mtase; cl17433
326427010570	DNA methylase; Region: N6_N4_Mtase; pfam01555
326427010571	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
326427010572	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
326427010573	DNA methylase; Region: N6_N4_Mtase; pfam01555
326427010574	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
326427010575	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
326427010576	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
326427010577	acyl-activating enzyme (AAE) consensus motif; other site
326427010578	putative AMP binding site [chemical binding]; other site
326427010579	putative active site [active]
326427010580	putative CoA binding site [chemical binding]; other site
326427010581	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858
326427010582	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
326427010583	catalytic triad [active]
326427010584	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
326427010585	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
326427010586	putative catalytic cysteine [active]
326427010587	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
326427010588	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
326427010589	Cupin; Region: Cupin_6; pfam12852
326427010590	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
326427010591	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
326427010592	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
326427010593	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
326427010594	Malic enzyme, N-terminal domain; Region: malic; pfam00390
326427010595	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
326427010596	putative NAD(P) binding site [chemical binding]; other site
326427010597	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
326427010598	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
326427010599	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
326427010600	Peptidase family M48; Region: Peptidase_M48; cl12018
326427010601	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326427010602	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427010603	active site
326427010604	phosphorylation site [posttranslational modification]
326427010605	intermolecular recognition site; other site
326427010606	dimerization interface [polypeptide binding]; other site
326427010607	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326427010608	DNA binding residues [nucleotide binding]
326427010609	dimerization interface [polypeptide binding]; other site
326427010610	dihydroorotase; Validated; Region: pyrC; PRK09357
326427010611	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326427010612	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
326427010613	active site
326427010614	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
326427010615	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
326427010616	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
326427010617	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
326427010618	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
326427010619	active site
326427010620	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
326427010621	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
326427010622	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326427010623	monogalactosyldiacylglycerol synthase; Region: PLN02605
326427010624	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
326427010625	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326427010626	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
326427010627	protoporphyrinogen oxidase; Region: PLN02576
326427010628	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
326427010629	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
326427010630	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326427010631	FeS/SAM binding site; other site
326427010632	HemN C-terminal domain; Region: HemN_C; pfam06969
326427010633	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427010634	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
326427010635	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
326427010636	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
326427010637	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
326427010638	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
326427010639	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
326427010640	catalytic core [active]
326427010641	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
326427010642	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
326427010643	ABC1 family; Region: ABC1; cl17513
326427010644	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
326427010645	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
326427010646	active site
326427010647	substrate binding site [chemical binding]; other site
326427010648	cosubstrate binding site; other site
326427010649	catalytic site [active]
326427010650	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
326427010651	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
326427010652	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
326427010653	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
326427010654	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
326427010655	GIY-YIG motif/motif A; other site
326427010656	putative active site [active]
326427010657	putative metal binding site [ion binding]; other site
326427010658	hydrolase, alpha/beta fold family protein; Region: PLN02679
326427010659	Cytochrome c; Region: Cytochrom_C; pfam00034
326427010660	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
326427010661	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
326427010662	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
326427010663	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
326427010664	molybdopterin cofactor binding site; other site
326427010665	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
326427010666	4Fe-4S binding domain; Region: Fer4_2; pfam12797
326427010667	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
326427010668	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
326427010669	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
326427010670	heme-binding residues [chemical binding]; other site
326427010671	GTP-binding protein YchF; Reviewed; Region: PRK09601
326427010672	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
326427010673	G1 box; other site
326427010674	GTP/Mg2+ binding site [chemical binding]; other site
326427010675	G2 box; other site
326427010676	Switch I region; other site
326427010677	G3 box; other site
326427010678	Switch II region; other site
326427010679	G4 box; other site
326427010680	G5 box; other site
326427010681	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
326427010682	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
326427010683	MOFRL family; Region: MOFRL; pfam05161
326427010684	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
326427010685	diphosphomevalonate decarboxylase; Region: PLN02407
326427010686	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
326427010687	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
326427010688	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
326427010689	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
326427010690	active site
326427010691	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
326427010692	active site
326427010693	substrate binding site [chemical binding]; other site
326427010694	ATP binding site [chemical binding]; other site
326427010695	Bacterial SH3 domain homologues; Region: SH3b; smart00287
326427010696	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
326427010697	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
326427010698	acyl-activating enzyme (AAE) consensus motif; other site
326427010699	AMP binding site [chemical binding]; other site
326427010700	active site
326427010701	CoA binding site [chemical binding]; other site
326427010702	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
326427010703	substrate binding site [chemical binding]; other site
326427010704	oxyanion hole (OAH) forming residues; other site
326427010705	trimer interface [polypeptide binding]; other site
326427010706	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
326427010707	NAD(P) binding site [chemical binding]; other site
326427010708	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
326427010709	NAD(P) binding site [chemical binding]; other site
326427010710	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
326427010711	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
326427010712	Mg++ binding site [ion binding]; other site
326427010713	putative catalytic motif [active]
326427010714	substrate binding site [chemical binding]; other site
326427010715	O-Antigen ligase; Region: Wzy_C; cl04850
326427010716	O-Antigen ligase; Region: Wzy_C; pfam04932
326427010717	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427010718	TPR motif; other site
326427010719	binding surface
326427010720	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
326427010721	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
326427010722	Walker A/P-loop; other site
326427010723	ATP binding site [chemical binding]; other site
326427010724	Q-loop/lid; other site
326427010725	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
326427010726	ABC transporter signature motif; other site
326427010727	Walker B; other site
326427010728	D-loop; other site
326427010729	H-loop/switch region; other site
326427010730	Uncharacterized conserved protein [Function unknown]; Region: COG3268
326427010731	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427010732	NAD(P) binding site [chemical binding]; other site
326427010733	amidase; Provisional; Region: PRK07486
326427010734	Amidase; Region: Amidase; pfam01425
326427010735	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
326427010736	intersubunit interface [polypeptide binding]; other site
326427010737	active site
326427010738	Zn2+ binding site [ion binding]; other site
326427010739	Protein of unknown function (DUF507); Region: DUF507; cl01112
326427010740	YtkA-like; Region: YtkA; pfam13115
326427010741	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
326427010742	catalytic residues [active]
326427010743	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
326427010744	CoA-transferase family III; Region: CoA_transf_3; pfam02515
326427010745	CHAT domain; Region: CHAT; pfam12770
326427010746	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
326427010747	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
326427010748	NAD(P) binding site [chemical binding]; other site
326427010749	catalytic residues [active]
326427010750	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
326427010751	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
326427010752	Walker A/P-loop; other site
326427010753	ATP binding site [chemical binding]; other site
326427010754	Q-loop/lid; other site
326427010755	ABC transporter signature motif; other site
326427010756	Walker B; other site
326427010757	D-loop; other site
326427010758	H-loop/switch region; other site
326427010759	Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151
326427010760	putative homodimer interface [polypeptide binding]; other site
326427010761	putative homotetramer interface [polypeptide binding]; other site
326427010762	allosteric switch controlling residues; other site
326427010763	putative metal binding site [ion binding]; other site
326427010764	putative homodimer-homodimer interface [polypeptide binding]; other site
326427010765	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
326427010766	metal-binding site [ion binding]
326427010767	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
326427010768	metal-binding site [ion binding]
326427010769	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
326427010770	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
326427010771	metal-binding site [ion binding]
326427010772	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
326427010773	Soluble P-type ATPase [General function prediction only]; Region: COG4087
326427010774	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
326427010775	diaminopimelate decarboxylase; Region: lysA; TIGR01048
326427010776	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
326427010777	active site
326427010778	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
326427010779	substrate binding site [chemical binding]; other site
326427010780	catalytic residues [active]
326427010781	dimer interface [polypeptide binding]; other site
326427010782	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
326427010783	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
326427010784	nucleotide binding site [chemical binding]; other site
326427010785	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
326427010786	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
326427010787	active site
326427010788	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
326427010789	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
326427010790	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
326427010791	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
326427010792	Cu(I) binding site [ion binding]; other site
326427010793	Protein of unknown function (DUF461); Region: DUF461; pfam04314
326427010794	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427010795	Coenzyme A binding pocket [chemical binding]; other site
326427010796	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
326427010797	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
326427010798	active site
326427010799	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
326427010800	Ligand Binding Site [chemical binding]; other site
326427010801	Molecular Tunnel; other site
326427010802	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
326427010803	endoglucanase; Region: PLN02308
326427010804	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
326427010805	Cellulose binding domain; Region: CBM_3; smart01067
326427010806	Cellulose binding domain; Region: CBM_2; pfam00553
326427010807	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
326427010808	CPxP  motif; other site
326427010809	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
326427010810	tyrosine phenol-lyase; Provisional; Region: PRK13237
326427010811	Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617
326427010812	substrate binding site [chemical binding]; other site
326427010813	tetramer interface [polypeptide binding]; other site
326427010814	catalytic residue [active]
326427010815	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
326427010816	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
326427010817	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
326427010818	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
326427010819	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
326427010820	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647
326427010821	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
326427010822	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438
326427010823	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
326427010824	CRISPR-associated protein (Cas_Cas02710); Region: Cas_Cas02710; pfam09670
326427010825	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
326427010826	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
326427010827	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
326427010828	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
326427010829	PhoU domain; Region: PhoU; pfam01895
326427010830	PhoU domain; Region: PhoU; pfam01895
326427010831	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
326427010832	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
326427010833	TrkA-C domain; Region: TrkA_C; pfam02080
326427010834	glyoxylate carboligase; Provisional; Region: PRK11269
326427010835	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
326427010836	PYR/PP interface [polypeptide binding]; other site
326427010837	dimer interface [polypeptide binding]; other site
326427010838	TPP binding site [chemical binding]; other site
326427010839	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
326427010840	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
326427010841	TPP-binding site [chemical binding]; other site
326427010842	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
326427010843	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
326427010844	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
326427010845	Deoxyhypusine synthase; Region: DS; cl00826
326427010846	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
326427010847	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
326427010848	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
326427010849	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
326427010850	Na binding site [ion binding]; other site
326427010851	Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529
326427010852	putative catalytic site [active]
326427010853	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
326427010854	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
326427010855	putative homodimer interface [polypeptide binding]; other site
326427010856	putative homotetramer interface [polypeptide binding]; other site
326427010857	putative allosteric switch controlling residues; other site
326427010858	putative metal binding site [ion binding]; other site
326427010859	putative homodimer-homodimer interface [polypeptide binding]; other site
326427010860	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
326427010861	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
326427010862	catalytic residues [active]
326427010863	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
326427010864	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
326427010865	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
326427010866	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
326427010867	dimer interface [polypeptide binding]; other site
326427010868	active site
326427010869	glycine-pyridoxal phosphate binding site [chemical binding]; other site
326427010870	folate binding site [chemical binding]; other site
326427010871	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
326427010872	Protein of unknown function (DUF3095); Region: DUF3095; pfam11294
326427010873	polyphosphate kinase; Provisional; Region: PRK05443
326427010874	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
326427010875	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
326427010876	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
326427010877	putative domain interface [polypeptide binding]; other site
326427010878	putative active site [active]
326427010879	catalytic site [active]
326427010880	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
326427010881	putative domain interface [polypeptide binding]; other site
326427010882	putative active site [active]
326427010883	catalytic site [active]
326427010884	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427010885	putative substrate translocation pore; other site
326427010886	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326427010887	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
326427010888	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
326427010889	NHL repeat; Region: NHL; pfam01436
326427010890	Uncharacterized conserved protein [Function unknown]; Region: COG3391
326427010891	NHL repeat; Region: NHL; pfam01436
326427010892	NHL repeat; Region: NHL; pfam01436
326427010893	NHL repeat; Region: NHL; pfam01436
326427010894	Phosphotransferase enzyme family; Region: APH; pfam01636
326427010895	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
326427010896	ATP binding site [chemical binding]; other site
326427010897	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
326427010898	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
326427010899	putative active site [active]
326427010900	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
326427010901	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
326427010902	P-loop; other site
326427010903	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
326427010904	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
326427010905	light-independent protochlorophyllide reductase, B subunit; Region: DPOR_BchB; TIGR01278
326427010906	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
326427010907	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
326427010908	light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842
326427010909	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
326427010910	Double zinc ribbon; Region: DZR; pfam12773
326427010911	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
326427010912	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
326427010913	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
326427010914	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
326427010915	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
326427010916	dimerization interface [polypeptide binding]; other site
326427010917	DPS ferroxidase diiron center [ion binding]; other site
326427010918	ion pore; other site
326427010919	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
326427010920	MoxR-like ATPases [General function prediction only]; Region: COG0714
326427010921	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
326427010922	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
326427010923	transmembrane helices; other site
326427010924	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
326427010925	TrkA-C domain; Region: TrkA_C; pfam02080
326427010926	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
326427010927	TrkA-C domain; Region: TrkA_C; pfam02080
326427010928	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
326427010929	Predicted membrane protein [Function unknown]; Region: COG2510
326427010930	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
326427010931	Domain of unknown function DUF20; Region: UPF0118; pfam01594
326427010932	Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430
326427010933	Domain interface; other site
326427010934	glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535
326427010935	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
326427010936	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
326427010937	Glucose dehydrogenase; Region: glucose_DH; cd08230
326427010938	NADP binding site [chemical binding]; other site
326427010939	catalytic Zn binding site [ion binding]; other site
326427010940	structural Zn binding site [ion binding]; other site
326427010941	dimer interface [polypeptide binding]; other site
326427010942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
326427010943	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326427010944	putative substrate translocation pore; other site
326427010945	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
326427010946	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
326427010947	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
326427010948	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326427010949	dimerization interface [polypeptide binding]; other site
326427010950	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427010951	dimer interface [polypeptide binding]; other site
326427010952	phosphorylation site [posttranslational modification]
326427010953	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427010954	ATP binding site [chemical binding]; other site
326427010955	Mg2+ binding site [ion binding]; other site
326427010956	G-X-G motif; other site
326427010957	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
326427010958	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427010959	active site
326427010960	phosphorylation site [posttranslational modification]
326427010961	intermolecular recognition site; other site
326427010962	dimerization interface [polypeptide binding]; other site
326427010963	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
326427010964	DNA binding site [nucleotide binding]
326427010965	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
326427010966	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427010967	putative active site [active]
326427010968	heme pocket [chemical binding]; other site
326427010969	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
326427010970	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427010971	putative active site [active]
326427010972	heme pocket [chemical binding]; other site
326427010973	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
326427010974	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427010975	putative active site [active]
326427010976	heme pocket [chemical binding]; other site
326427010977	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427010978	putative active site [active]
326427010979	heme pocket [chemical binding]; other site
326427010980	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
326427010981	metal binding site [ion binding]; metal-binding site
326427010982	active site
326427010983	I-site; other site
326427010984	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
326427010985	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
326427010986	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
326427010987	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
326427010988	active site
326427010989	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
326427010990	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
326427010991	Walker A/P-loop; other site
326427010992	ATP binding site [chemical binding]; other site
326427010993	Q-loop/lid; other site
326427010994	ABC transporter signature motif; other site
326427010995	Walker B; other site
326427010996	D-loop; other site
326427010997	H-loop/switch region; other site
326427010998	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
326427010999	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
326427011000	Walker A/P-loop; other site
326427011001	ATP binding site [chemical binding]; other site
326427011002	Q-loop/lid; other site
326427011003	ABC transporter signature motif; other site
326427011004	Walker B; other site
326427011005	D-loop; other site
326427011006	H-loop/switch region; other site
326427011007	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
326427011008	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
326427011009	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
326427011010	Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845
326427011011	phosphonate C-P lyase system protein PhnG; Region: PhnG_redo; TIGR03293
326427011012	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
326427011013	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
326427011014	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
326427011015	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
326427011016	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
326427011017	Walker A/P-loop; other site
326427011018	ATP binding site [chemical binding]; other site
326427011019	Q-loop/lid; other site
326427011020	ABC transporter signature motif; other site
326427011021	Walker B; other site
326427011022	D-loop; other site
326427011023	H-loop/switch region; other site
326427011024	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
326427011025	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
326427011026	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427011027	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
326427011028	Coenzyme A binding pocket [chemical binding]; other site
326427011029	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
326427011030	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
326427011031	NADP binding site [chemical binding]; other site
326427011032	dimer interface [polypeptide binding]; other site
326427011033	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
326427011034	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
326427011035	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
326427011036	hydrophobic ligand binding site; other site
326427011037	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
326427011038	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
326427011039	Cl- selectivity filter; other site
326427011040	Cl- binding residues [ion binding]; other site
326427011041	pore gating glutamate residue; other site
326427011042	dimer interface [polypeptide binding]; other site
326427011043	H+/Cl- coupling transport residue; other site
326427011044	TrkA-C domain; Region: TrkA_C; pfam02080
326427011045	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
326427011046	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
326427011047	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
326427011048	active site
326427011049	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
326427011050	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
326427011051	active site
326427011052	PHP-associated; Region: PHP_C; pfam13263
326427011053	hypothetical protein; Provisional; Region: PRK08201
326427011054	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
326427011055	metal binding site [ion binding]; metal-binding site
326427011056	putative dimer interface [polypeptide binding]; other site
326427011057	DinB superfamily; Region: DinB_2; pfam12867
326427011058	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
326427011059	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
326427011060	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
326427011061	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
326427011062	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
326427011063	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
326427011064	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
326427011065	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
326427011066	FeoA domain; Region: FeoA; pfam04023
326427011067	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
326427011068	FeoA domain; Region: FeoA; pfam04023
326427011069	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
326427011070	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
326427011071	G1 box; other site
326427011072	GTP/Mg2+ binding site [chemical binding]; other site
326427011073	Switch I region; other site
326427011074	G2 box; other site
326427011075	G3 box; other site
326427011076	Switch II region; other site
326427011077	G4 box; other site
326427011078	G5 box; other site
326427011079	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
326427011080	Nucleoside recognition; Region: Gate; pfam07670
326427011081	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
326427011082	Nucleoside recognition; Region: Gate; pfam07670
326427011083	FeoC like transcriptional regulator; Region: FeoC; pfam09012
326427011084	Uncharacterized conserved protein [Function unknown]; Region: COG1284
326427011085	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
326427011086	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
326427011087	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
326427011088	S-adenosylmethionine synthetase; Validated; Region: PRK05250
326427011089	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
326427011090	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
326427011091	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
326427011092	PAS domain; Region: PAS_9; pfam13426
326427011093	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427011094	putative active site [active]
326427011095	heme pocket [chemical binding]; other site
326427011096	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427011097	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
326427011098	putative active site [active]
326427011099	heme pocket [chemical binding]; other site
326427011100	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427011101	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
326427011102	putative active site [active]
326427011103	heme pocket [chemical binding]; other site
326427011104	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427011105	putative active site [active]
326427011106	heme pocket [chemical binding]; other site
326427011107	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
326427011108	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
326427011109	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
326427011110	intersubunit interface [polypeptide binding]; other site
326427011111	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
326427011112	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
326427011113	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
326427011114	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
326427011115	ABC-ATPase subunit  interface; other site
326427011116	dimer interface [polypeptide binding]; other site
326427011117	putative PBP binding regions; other site
326427011118	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
326427011119	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
326427011120	ABC-ATPase subunit  interface; other site
326427011121	dimer interface [polypeptide binding]; other site
326427011122	putative PBP binding regions; other site
326427011123	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
326427011124	TrkA-N domain; Region: TrkA_N; pfam02254
326427011125	TrkA-C domain; Region: TrkA_C; pfam02080
326427011126	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
326427011127	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
326427011128	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
326427011129	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326427011130	FeS/SAM binding site; other site
326427011131	HemN C-terminal domain; Region: HemN_C; pfam06969
326427011132	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
326427011133	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
326427011134	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
326427011135	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
326427011136	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
326427011137	substrate binding site [chemical binding]; other site
326427011138	ATP binding site [chemical binding]; other site
326427011139	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
326427011140	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
326427011141	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
326427011142	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
326427011143	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
326427011144	homotetramer interface [polypeptide binding]; other site
326427011145	ligand binding site [chemical binding]; other site
326427011146	catalytic site [active]
326427011147	NAD binding site [chemical binding]; other site
326427011148	S-adenosylmethionine synthetase; Validated; Region: PRK05250
326427011149	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
326427011150	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
326427011151	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
326427011152	Uncharacterized conserved protein [Function unknown]; Region: COG1284
326427011153	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
326427011154	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
326427011155	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
326427011156	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
326427011157	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
326427011158	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
326427011159	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
326427011160	RNA binding site [nucleotide binding]; other site
326427011161	active site
326427011162	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
326427011163	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
326427011164	DHH family; Region: DHH; pfam01368
326427011165	DHHA1 domain; Region: DHHA1; pfam02272
326427011166	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
326427011167	putative active site [active]
326427011168	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
326427011169	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
326427011170	GatB domain; Region: GatB_Yqey; smart00845
326427011171	Bacterial SH3 domain; Region: SH3_3; pfam08239
326427011172	Thymidylate synthase complementing protein; Region: Thy1; cl03630
326427011173	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
326427011174	N-acetylmuramoyl-L-alanine amidase; Region: Amidase_3; pfam01520
326427011175	active site
326427011176	metal binding site [ion binding]; metal-binding site
326427011177	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
326427011178	RHS Repeat; Region: RHS_repeat; pfam05593
326427011179	RHS Repeat; Region: RHS_repeat; pfam05593
326427011180	RHS Repeat; Region: RHS_repeat; pfam05593
326427011181	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
326427011182	RHS Repeat; Region: RHS_repeat; pfam05593
326427011183	RHS Repeat; Region: RHS_repeat; pfam05593
326427011184	RHS Repeat; Region: RHS_repeat; pfam05593
326427011185	RHS Repeat; Region: RHS_repeat; pfam05593
326427011186	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
326427011187	RHS Repeat; Region: RHS_repeat; pfam05593
326427011188	RHS Repeat; Region: RHS_repeat; pfam05593
326427011189	RHS Repeat; Region: RHS_repeat; pfam05593
326427011190	RHS Repeat; Region: RHS_repeat; pfam05593
326427011191	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
326427011192	RHS Repeat; Region: RHS_repeat; pfam05593
326427011193	RHS Repeat; Region: RHS_repeat; pfam05593
326427011194	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
326427011195	RHS Repeat; Region: RHS_repeat; pfam05593
326427011196	RHS Repeat; Region: RHS_repeat; pfam05593
326427011197	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
326427011198	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
326427011199	Family description; Region: VCBS; pfam13517
326427011200	Family description; Region: VCBS; pfam13517
326427011201	FG-GAP repeat; Region: FG-GAP; pfam01839
326427011202	Family description; Region: VCBS; pfam13517
326427011203	Family description; Region: VCBS; pfam13517
326427011204	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
326427011205	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
326427011206	catalytic core [active]
326427011207	RDD family; Region: RDD; pfam06271
326427011208	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
326427011209	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
326427011210	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
326427011211	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
326427011212	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
326427011213	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
326427011214	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
326427011215	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427011216	S-adenosylmethionine binding site [chemical binding]; other site
326427011217	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
326427011218	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
326427011219	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
326427011220	catalytic residues [active]
326427011221	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
326427011222	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
326427011223	putative active site [active]
326427011224	oxyanion strand; other site
326427011225	catalytic triad [active]
326427011226	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
326427011227	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
326427011228	active site
326427011229	Zn binding site [ion binding]; other site
326427011230	DNA polymerase I; Provisional; Region: PRK05755
326427011231	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
326427011232	active site
326427011233	metal binding site 1 [ion binding]; metal-binding site
326427011234	putative 5' ssDNA interaction site; other site
326427011235	metal binding site 3; metal-binding site
326427011236	metal binding site 2 [ion binding]; metal-binding site
326427011237	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
326427011238	putative DNA binding site [nucleotide binding]; other site
326427011239	putative metal binding site [ion binding]; other site
326427011240	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
326427011241	active site
326427011242	catalytic site [active]
326427011243	substrate binding site [chemical binding]; other site
326427011244	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
326427011245	active site
326427011246	DNA binding site [nucleotide binding]
326427011247	catalytic site [active]
326427011248	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
326427011249	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
326427011250	Ligand binding site; other site
326427011251	Putative Catalytic site; other site
326427011252	DXD motif; other site
326427011253	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
326427011254	SPFH domain / Band 7 family; Region: Band_7; pfam01145
326427011255	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
326427011256	catalytic residues [active]
326427011257	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
326427011258	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
326427011259	catalytic residues [active]
326427011260	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
326427011261	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
326427011262	Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144
326427011263	ATP-grasp domain; Region: ATP-grasp_4; cl17255
326427011264	lysine biosynthesis protein LysW; Region: lysW; TIGR01206
326427011265	lysine biosynthesis protein LysW; Region: lysW; TIGR01206
326427011266	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
326427011267	tartrate dehydrogenase; Region: TTC; TIGR02089
326427011268	homoaconitate hydratase small subunit; Provisional; Region: PRK14023
326427011269	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
326427011270	substrate binding site [chemical binding]; other site
326427011271	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
326427011272	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
326427011273	substrate binding site [chemical binding]; other site
326427011274	ligand binding site [chemical binding]; other site
326427011275	Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948
326427011276	homocitrate synthase; Region: LysS_fung_arch; TIGR02146
326427011277	active site
326427011278	catalytic residues [active]
326427011279	metal binding site [ion binding]; metal-binding site
326427011280	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
326427011281	Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein).  Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401
326427011282	Cupin domain; Region: Cupin_2; cl17218
326427011283	YwiC-like protein; Region: YwiC; pfam14256
326427011284	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
326427011285	chaperone protein DnaJ; Provisional; Region: PRK14299
326427011286	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
326427011287	HSP70 interaction site [polypeptide binding]; other site
326427011288	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
326427011289	substrate binding site [polypeptide binding]; other site
326427011290	dimer interface [polypeptide binding]; other site
326427011291	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
326427011292	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
326427011293	protein binding site [polypeptide binding]; other site
326427011294	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
326427011295	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
326427011296	putative dimer interface [polypeptide binding]; other site
326427011297	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
326427011298	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
326427011299	Walker A motif; other site
326427011300	ATP binding site [chemical binding]; other site
326427011301	Walker B motif; other site
326427011302	arginine finger; other site
326427011303	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
326427011304	Thioredoxin; Region: Thioredoxin_4; pfam13462
326427011305	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
326427011306	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
326427011307	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
326427011308	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
326427011309	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
326427011310	putative active site [active]
326427011311	substrate binding site [chemical binding]; other site
326427011312	redox center [active]
326427011313	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
326427011314	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
326427011315	ligand binding site [chemical binding]; other site
326427011316	NAD binding site [chemical binding]; other site
326427011317	dimerization interface [polypeptide binding]; other site
326427011318	catalytic site [active]
326427011319	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
326427011320	putative L-serine binding site [chemical binding]; other site
326427011321	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
326427011322	dimer interface [polypeptide binding]; other site
326427011323	active site
326427011324	putative chaperone; Provisional; Region: PRK11678
326427011325	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
326427011326	nucleotide binding site [chemical binding]; other site
326427011327	putative NEF/HSP70 interaction site [polypeptide binding]; other site
326427011328	SBD interface [polypeptide binding]; other site
326427011329	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
326427011330	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
326427011331	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
326427011332	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
326427011333	Double zinc ribbon; Region: DZR; pfam12773
326427011334	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
326427011335	transcription termination factor Rho; Provisional; Region: rho; PRK09376
326427011336	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
326427011337	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
326427011338	RNA binding site [nucleotide binding]; other site
326427011339	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
326427011340	multimer interface [polypeptide binding]; other site
326427011341	Walker A motif; other site
326427011342	ATP binding site [chemical binding]; other site
326427011343	Walker B motif; other site
326427011344	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
326427011345	active site
326427011346	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
326427011347	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
326427011348	Walker A/P-loop; other site
326427011349	ATP binding site [chemical binding]; other site
326427011350	Q-loop/lid; other site
326427011351	ABC transporter signature motif; other site
326427011352	Walker B; other site
326427011353	D-loop; other site
326427011354	H-loop/switch region; other site
326427011355	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427011356	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
326427011357	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
326427011358	GAF domain; Region: GAF; pfam01590
326427011359	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
326427011360	Histidine kinase; Region: HisKA_2; pfam07568
326427011361	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427011362	ATP binding site [chemical binding]; other site
326427011363	Mg2+ binding site [ion binding]; other site
326427011364	G-X-G motif; other site
326427011365	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
326427011366	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
326427011367	amidase catalytic site [active]
326427011368	Zn binding residues [ion binding]; other site
326427011369	substrate binding site [chemical binding]; other site
326427011370	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
326427011371	substrate binding site [chemical binding]; other site
326427011372	adhesin; Provisional; Region: PRK09752
326427011373	phosphate binding protein; Region: ptsS_2; TIGR02136
326427011374	phosphate binding protein; Region: ptsS_2; TIGR02136
326427011375	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
326427011376	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427011377	dimer interface [polypeptide binding]; other site
326427011378	conserved gate region; other site
326427011379	putative PBP binding loops; other site
326427011380	ABC-ATPase subunit interface; other site
326427011381	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
326427011382	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427011383	dimer interface [polypeptide binding]; other site
326427011384	conserved gate region; other site
326427011385	putative PBP binding loops; other site
326427011386	ABC-ATPase subunit interface; other site
326427011387	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
326427011388	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
326427011389	Walker A/P-loop; other site
326427011390	ATP binding site [chemical binding]; other site
326427011391	Q-loop/lid; other site
326427011392	ABC transporter signature motif; other site
326427011393	Walker B; other site
326427011394	D-loop; other site
326427011395	H-loop/switch region; other site
326427011396	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
326427011397	EDD domain protein, DegV family; Region: DegV; TIGR00762
326427011398	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
326427011399	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
326427011400	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
326427011401	generic binding surface II; other site
326427011402	ssDNA binding site; other site
326427011403	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326427011404	ATP binding site [chemical binding]; other site
326427011405	putative Mg++ binding site [ion binding]; other site
326427011406	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326427011407	nucleotide binding region [chemical binding]; other site
326427011408	ATP-binding site [chemical binding]; other site
326427011409	e3 binding domain; Region: E3_binding; pfam02817
326427011410	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
326427011411	6-phosphofructokinase; Provisional; Region: PRK03202
326427011412	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
326427011413	active site
326427011414	ADP/pyrophosphate binding site [chemical binding]; other site
326427011415	dimerization interface [polypeptide binding]; other site
326427011416	allosteric effector site; other site
326427011417	fructose-1,6-bisphosphate binding site; other site
326427011418	Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862
326427011419	putative hydrophobic ligand binding site [chemical binding]; other site
326427011420	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
326427011421	large tegument protein UL36; Provisional; Region: PHA03247
326427011422	MutL protein; Region: MutL; pfam13941
326427011423	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778
326427011424	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
326427011425	TPP-binding site [chemical binding]; other site
326427011426	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
326427011427	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
326427011428	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
326427011429	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
326427011430	PYR/PP interface [polypeptide binding]; other site
326427011431	TPP binding site [chemical binding]; other site
326427011432	dimer interface [polypeptide binding]; other site
326427011433	substrate binding site [chemical binding]; other site
326427011434	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
326427011435	active site
326427011436	UV-endonuclease UvdE; Region: UvdE; cl10036
326427011437	TPR repeat; Region: TPR_11; pfam13414
326427011438	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427011439	TPR motif; other site
326427011440	binding surface
326427011441	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427011442	binding surface
326427011443	Tetratricopeptide repeat; Region: TPR_16; pfam13432
326427011444	TPR motif; other site
326427011445	ribonuclease PH; Reviewed; Region: rph; PRK00173
326427011446	Ribonuclease PH; Region: RNase_PH_bact; cd11362
326427011447	hexamer interface [polypeptide binding]; other site
326427011448	active site
326427011449	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
326427011450	endonuclease III; Region: ENDO3c; smart00478
326427011451	minor groove reading motif; other site
326427011452	helix-hairpin-helix signature motif; other site
326427011453	substrate binding pocket [chemical binding]; other site
326427011454	active site
326427011455	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
326427011456	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
326427011457	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
326427011458	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
326427011459	nucleotide binding pocket [chemical binding]; other site
326427011460	K-X-D-G motif; other site
326427011461	catalytic site [active]
326427011462	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
326427011463	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
326427011464	Helix-hairpin-helix motif; Region: HHH; pfam00633
326427011465	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
326427011466	Dimer interface [polypeptide binding]; other site
326427011467	BRCT sequence motif; other site
326427011468	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
326427011469	UbiA prenyltransferase family; Region: UbiA; pfam01040
326427011470	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
326427011471	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
326427011472	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
326427011473	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258
326427011474	tetrathionate reductase subunit A; Provisional; Region: PRK14991
326427011475	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
326427011476	molybdopterin cofactor binding site; other site
326427011477	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
326427011478	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
326427011479	putative molybdopterin cofactor binding site; other site
326427011480	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
326427011481	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
326427011482	4Fe-4S binding domain; Region: Fer4_6; pfam12837
326427011483	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
326427011484	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427011485	active site
326427011486	phosphorylation site [posttranslational modification]
326427011487	intermolecular recognition site; other site
326427011488	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
326427011489	DNA binding residues [nucleotide binding]
326427011490	dimerization interface [polypeptide binding]; other site
326427011491	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
326427011492	dimerization interface [polypeptide binding]; other site
326427011493	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
326427011494	Histidine kinase; Region: HisKA_3; pfam07730
326427011495	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427011496	ATP binding site [chemical binding]; other site
326427011497	Mg2+ binding site [ion binding]; other site
326427011498	G-X-G motif; other site
326427011499	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
326427011500	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
326427011501	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
326427011502	Predicted permeases [General function prediction only]; Region: COG0701
326427011503	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
326427011504	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
326427011505	dimerization interface [polypeptide binding]; other site
326427011506	putative DNA binding site [nucleotide binding]; other site
326427011507	putative Zn2+ binding site [ion binding]; other site
326427011508	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
326427011509	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
326427011510	DNA binding residues [nucleotide binding]
326427011511	Major Facilitator Superfamily; Region: MFS_1; pfam07690
326427011512	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
326427011513	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
326427011514	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
326427011515	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
326427011516	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427011517	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
326427011518	translation initiation factor IF-2; Region: IF-2; TIGR00487
326427011519	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
326427011520	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
326427011521	G1 box; other site
326427011522	putative GEF interaction site [polypeptide binding]; other site
326427011523	GTP/Mg2+ binding site [chemical binding]; other site
326427011524	Switch I region; other site
326427011525	G2 box; other site
326427011526	G3 box; other site
326427011527	Switch II region; other site
326427011528	G4 box; other site
326427011529	G5 box; other site
326427011530	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
326427011531	Translation-initiation factor 2; Region: IF-2; pfam11987
326427011532	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
326427011533	Protein of unknown function (DUF448); Region: DUF448; pfam04296
326427011534	putative RNA binding cleft [nucleotide binding]; other site
326427011535	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
326427011536	NusA N-terminal domain; Region: NusA_N; pfam08529
326427011537	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
326427011538	RNA binding site [nucleotide binding]; other site
326427011539	homodimer interface [polypeptide binding]; other site
326427011540	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
326427011541	G-X-X-G motif; other site
326427011542	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
326427011543	G-X-X-G motif; other site
326427011544	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
326427011545	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427011546	ATP binding site [chemical binding]; other site
326427011547	Mg2+ binding site [ion binding]; other site
326427011548	G-X-G motif; other site
326427011549	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
326427011550	anchoring element; other site
326427011551	dimer interface [polypeptide binding]; other site
326427011552	ATP binding site [chemical binding]; other site
326427011553	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
326427011554	active site
326427011555	putative metal-binding site [ion binding]; other site
326427011556	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
326427011557	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
326427011558	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
326427011559	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427011560	Coenzyme A binding pocket [chemical binding]; other site
326427011561	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
326427011562	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
326427011563	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
326427011564	putative deacylase active site [active]
326427011565	leucyl-tRNA synthetase; Reviewed; Region: leuS; PRK12300
326427011566	CHAT domain; Region: CHAT; pfam12770
326427011567	AAA ATPase domain; Region: AAA_16; pfam13191
326427011568	NB-ARC domain; Region: NB-ARC; pfam00931
326427011569	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427011570	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427011571	binding surface
326427011572	TPR motif; other site
326427011573	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427011574	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427011575	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427011576	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427011577	binding surface
326427011578	TPR motif; other site
326427011579	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427011580	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427011581	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427011582	binding surface
326427011583	TPR motif; other site
326427011584	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427011585	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427011586	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427011587	binding surface
326427011588	TPR motif; other site
326427011589	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427011590	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427011591	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427011592	binding surface
326427011593	TPR motif; other site
326427011594	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427011595	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427011596	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
326427011597	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
326427011598	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
326427011599	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
326427011600	pyridoxal 5'-phosphate binding site [chemical binding]; other site
326427011601	catalytic residue [active]
326427011602	Trm112p-like protein; Region: Trm112p; cl01066
326427011603	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
326427011604	putative active site [active]
326427011605	putative metal binding site [ion binding]; other site
326427011606	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
326427011607	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
326427011608	active site
326427011609	Uncharacterized conserved protein [Function unknown]; Region: COG1432
326427011610	LabA_like proteins; Region: LabA_like; cd06167
326427011611	putative metal binding site [ion binding]; other site
326427011612	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
326427011613	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
326427011614	Probable Catalytic site; other site
326427011615	metal-binding site
326427011616	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
326427011617	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
326427011618	active site
326427011619	dimerization interface [polypeptide binding]; other site
326427011620	Radical SAM superfamily; Region: Radical_SAM; pfam04055
326427011621	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
326427011622	FeS/SAM binding site; other site
326427011623	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
326427011624	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
326427011625	Coenzyme A binding pocket [chemical binding]; other site
326427011626	ribonuclease Y; Region: RNase_Y; TIGR03319
326427011627	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
326427011628	Zn2+ binding site [ion binding]; other site
326427011629	Mg2+ binding site [ion binding]; other site
326427011630	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
326427011631	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
326427011632	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326427011633	ligand binding site [chemical binding]; other site
326427011634	flexible hinge region; other site
326427011635	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
326427011636	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
326427011637	metal binding triad; other site
326427011638	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
326427011639	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
326427011640	active site
326427011641	catalytic site [active]
326427011642	substrate binding site [chemical binding]; other site
326427011643	Transcriptional regulators [Transcription]; Region: PurR; COG1609
326427011644	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
326427011645	DNA binding site [nucleotide binding]
326427011646	domain linker motif; other site
326427011647	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
326427011648	putative dimerization interface [polypeptide binding]; other site
326427011649	putative ligand binding site [chemical binding]; other site
326427011650	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
326427011651	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
326427011652	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427011653	dimer interface [polypeptide binding]; other site
326427011654	conserved gate region; other site
326427011655	ABC-ATPase subunit interface; other site
326427011656	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
326427011657	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
326427011658	dimer interface [polypeptide binding]; other site
326427011659	conserved gate region; other site
326427011660	ABC-ATPase subunit interface; other site
326427011661	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
326427011662	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
326427011663	substrate binding [chemical binding]; other site
326427011664	active site
326427011665	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
326427011666	aconitate hydratase; Validated; Region: PRK09277
326427011667	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
326427011668	substrate binding site [chemical binding]; other site
326427011669	ligand binding site [chemical binding]; other site
326427011670	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
326427011671	substrate binding site [chemical binding]; other site
326427011672	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
326427011673	E3 interaction surface; other site
326427011674	lipoyl attachment site [posttranslational modification]; other site
326427011675	e3 binding domain; Region: E3_binding; pfam02817
326427011676	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
326427011677	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
326427011678	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
326427011679	TPP-binding site [chemical binding]; other site
326427011680	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
326427011681	dimer interface [polypeptide binding]; other site
326427011682	PYR/PP interface [polypeptide binding]; other site
326427011683	TPP binding site [chemical binding]; other site
326427011684	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
326427011685	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
326427011686	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
326427011687	Colicin V production protein; Region: Colicin_V; pfam02674
326427011688	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
326427011689	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
326427011690	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
326427011691	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
326427011692	nucleotide binding site [chemical binding]; other site
326427011693	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326427011694	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326427011695	active site
326427011696	ATP binding site [chemical binding]; other site
326427011697	substrate binding site [chemical binding]; other site
326427011698	activation loop (A-loop); other site
326427011699	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
326427011700	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
326427011701	active site
326427011702	Trp docking motif [polypeptide binding]; other site
326427011703	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
326427011704	active site
326427011705	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
326427011706	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
326427011707	metal ion-dependent adhesion site (MIDAS); other site
326427011708	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
326427011709	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
326427011710	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
326427011711	phosphopeptide binding site; other site
326427011712	agmatinase; Region: agmatinase; TIGR01230
326427011713	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
326427011714	putative active site [active]
326427011715	putative metal binding site [ion binding]; other site
326427011716	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
326427011717	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
326427011718	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
326427011719	Citrate synthase; Region: Citrate_synt; pfam00285
326427011720	oxalacetate binding site [chemical binding]; other site
326427011721	citrylCoA binding site [chemical binding]; other site
326427011722	coenzyme A binding site [chemical binding]; other site
326427011723	catalytic triad [active]
326427011724	enolase; Provisional; Region: eno; PRK00077
326427011725	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
326427011726	dimer interface [polypeptide binding]; other site
326427011727	metal binding site [ion binding]; metal-binding site
326427011728	substrate binding pocket [chemical binding]; other site
326427011729	EamA-like transporter family; Region: EamA; pfam00892
326427011730	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
326427011731	EamA-like transporter family; Region: EamA; pfam00892
326427011732	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
326427011733	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
326427011734	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
326427011735	ATP binding site [chemical binding]; other site
326427011736	putative Mg++ binding site [ion binding]; other site
326427011737	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
326427011738	nucleotide binding region [chemical binding]; other site
326427011739	ATP-binding site [chemical binding]; other site
326427011740	TRCF domain; Region: TRCF; pfam03461
326427011741	Double zinc ribbon; Region: DZR; pfam12773
326427011742	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
326427011743	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
326427011744	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
326427011745	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326427011746	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427011747	dimer interface [polypeptide binding]; other site
326427011748	phosphorylation site [posttranslational modification]
326427011749	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427011750	ATP binding site [chemical binding]; other site
326427011751	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
326427011752	dimer interface [polypeptide binding]; other site
326427011753	ADP-ribose binding site [chemical binding]; other site
326427011754	active site
326427011755	nudix motif; other site
326427011756	metal binding site [ion binding]; metal-binding site
326427011757	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427011758	S-adenosylmethionine binding site [chemical binding]; other site
326427011759	Flagellin N-methylase; Region: FliB; cl00497
326427011760	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
326427011761	LrgA family; Region: LrgA; pfam03788
326427011762	GTP-binding protein Der; Reviewed; Region: PRK00093
326427011763	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
326427011764	G1 box; other site
326427011765	GTP/Mg2+ binding site [chemical binding]; other site
326427011766	Switch I region; other site
326427011767	G2 box; other site
326427011768	Switch II region; other site
326427011769	G3 box; other site
326427011770	G4 box; other site
326427011771	G5 box; other site
326427011772	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
326427011773	G1 box; other site
326427011774	GTP/Mg2+ binding site [chemical binding]; other site
326427011775	Switch I region; other site
326427011776	G2 box; other site
326427011777	G3 box; other site
326427011778	Switch II region; other site
326427011779	G4 box; other site
326427011780	G5 box; other site
326427011781	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
326427011782	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
326427011783	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
326427011784	active site
326427011785	catalytic site [active]
326427011786	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
326427011787	PAS domain; Region: PAS_9; pfam13426
326427011788	putative active site [active]
326427011789	heme pocket [chemical binding]; other site
326427011790	PAS fold; Region: PAS_3; pfam08447
326427011791	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
326427011792	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
326427011793	dimer interface [polypeptide binding]; other site
326427011794	phosphorylation site [posttranslational modification]
326427011795	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
326427011796	ATP binding site [chemical binding]; other site
326427011797	Mg2+ binding site [ion binding]; other site
326427011798	G-X-G motif; other site
326427011799	Response regulator receiver domain; Region: Response_reg; pfam00072
326427011800	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
326427011801	active site
326427011802	phosphorylation site [posttranslational modification]
326427011803	intermolecular recognition site; other site
326427011804	dimerization interface [polypeptide binding]; other site
326427011805	intracellular protease, PfpI family; Region: PfpI; TIGR01382
326427011806	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
326427011807	conserved cys residue [active]
326427011808	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
326427011809	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
326427011810	metal ion-dependent adhesion site (MIDAS); other site
326427011811	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
326427011812	metal ion-dependent adhesion site (MIDAS); other site
326427011813	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
326427011814	FixH; Region: FixH; pfam05751
326427011815	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
326427011816	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
326427011817	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
326427011818	Family description; Region: UvrD_C_2; pfam13538
326427011819	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
326427011820	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326427011821	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326427011822	DNA binding residues [nucleotide binding]
326427011823	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
326427011824	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
326427011825	ligand binding site [chemical binding]; other site
326427011826	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
326427011827	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
326427011828	ligand binding site [chemical binding]; other site
326427011829	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
326427011830	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
326427011831	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
326427011832	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
326427011833	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
326427011834	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
326427011835	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
326427011836	putative dimer interface [polypeptide binding]; other site
326427011837	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
326427011838	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
326427011839	tetramer interface [polypeptide binding]; other site
326427011840	TPP-binding site [chemical binding]; other site
326427011841	heterodimer interface [polypeptide binding]; other site
326427011842	phosphorylation loop region [posttranslational modification]
326427011843	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
326427011844	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
326427011845	alpha subunit interface [polypeptide binding]; other site
326427011846	TPP binding site [chemical binding]; other site
326427011847	heterodimer interface [polypeptide binding]; other site
326427011848	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
326427011849	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
326427011850	MutS domain I; Region: MutS_I; pfam01624
326427011851	MutS domain II; Region: MutS_II; pfam05188
326427011852	MutS domain III; Region: MutS_III; pfam05192
326427011853	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
326427011854	Walker A/P-loop; other site
326427011855	ATP binding site [chemical binding]; other site
326427011856	Q-loop/lid; other site
326427011857	ABC transporter signature motif; other site
326427011858	Walker B; other site
326427011859	D-loop; other site
326427011860	H-loop/switch region; other site
326427011861	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
326427011862	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
326427011863	active site
326427011864	Riboflavin kinase; Region: Flavokinase; smart00904
326427011865	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427011866	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
326427011867	NAD(P) binding site [chemical binding]; other site
326427011868	active site
326427011869	adenylate kinase; Reviewed; Region: adk; PRK00279
326427011870	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
326427011871	AMP-binding site [chemical binding]; other site
326427011872	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
326427011873	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326427011874	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326427011875	active site
326427011876	ATP binding site [chemical binding]; other site
326427011877	substrate binding site [chemical binding]; other site
326427011878	activation loop (A-loop); other site
326427011879	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427011880	TPR repeat; Region: TPR_11; pfam13414
326427011881	TPR motif; other site
326427011882	binding surface
326427011883	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427011884	TPR motif; other site
326427011885	Tetratricopeptide repeat; Region: TPR_12; pfam13424
326427011886	binding surface
326427011887	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
326427011888	binding surface
326427011889	TPR motif; other site
326427011890	TPR repeat; Region: TPR_11; pfam13414
326427011891	Lamin Tail Domain; Region: LTD; pfam00932
326427011892	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
326427011893	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
326427011894	active site
326427011895	Substrate binding site; other site
326427011896	Mg++ binding site; other site
326427011897	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
326427011898	putative trimer interface [polypeptide binding]; other site
326427011899	putative CoA binding site [chemical binding]; other site
326427011900	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
326427011901	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
326427011902	HEAT repeats; Region: HEAT_2; pfam13646
326427011903	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
326427011904	RNA binding site [nucleotide binding]; other site
326427011905	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
326427011906	RNA binding site [nucleotide binding]; other site
326427011907	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
326427011908	malonyl-CoA synthase; Validated; Region: PRK07514
326427011909	acyl-activating enzyme (AAE) consensus motif; other site
326427011910	active site
326427011911	AMP binding site [chemical binding]; other site
326427011912	CoA binding site [chemical binding]; other site
326427011913	pyruvate phosphate dikinase; Provisional; Region: PRK09279
326427011914	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
326427011915	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
326427011916	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
326427011917	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
326427011918	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
326427011919	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
326427011920	nucleophilic elbow; other site
326427011921	catalytic triad; other site
326427011922	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
326427011923	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
326427011924	ligand binding site [chemical binding]; other site
326427011925	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
326427011926	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
326427011927	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
326427011928	NAD(P) binding site [chemical binding]; other site
326427011929	active site
326427011930	malate synthase A; Region: malate_syn_A; TIGR01344
326427011931	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
326427011932	active site
326427011933	septum formation inhibitor; Reviewed; Region: minC; PRK00513
326427011934	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
326427011935	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
326427011936	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
326427011937	Switch I; other site
326427011938	Switch II; other site
326427011939	cell division topological specificity factor MinE; Provisional; Region: PRK13991
326427011940	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
326427011941	Domain of unknown function DUF20; Region: UPF0118; pfam01594
326427011942	GTPase Era; Reviewed; Region: era; PRK00089
326427011943	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
326427011944	G1 box; other site
326427011945	GTP/Mg2+ binding site [chemical binding]; other site
326427011946	Switch I region; other site
326427011947	G2 box; other site
326427011948	Switch II region; other site
326427011949	G3 box; other site
326427011950	G4 box; other site
326427011951	G5 box; other site
326427011952	KH domain; Region: KH_2; pfam07650
326427011953	Double zinc ribbon; Region: DZR; pfam12773
326427011954	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
326427011955	Catalytic domain of Protein Kinases; Region: PKc; cd00180
326427011956	active site
326427011957	ATP binding site [chemical binding]; other site
326427011958	substrate binding site [chemical binding]; other site
326427011959	activation loop (A-loop); other site
326427011960	acetyl-CoA synthetase; Provisional; Region: PRK00174
326427011961	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
326427011962	active site
326427011963	CoA binding site [chemical binding]; other site
326427011964	acyl-activating enzyme (AAE) consensus motif; other site
326427011965	AMP binding site [chemical binding]; other site
326427011966	acetate binding site [chemical binding]; other site
326427011967	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
326427011968	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
326427011969	acyl-activating enzyme (AAE) consensus motif; other site
326427011970	putative AMP binding site [chemical binding]; other site
326427011971	putative active site [active]
326427011972	putative CoA binding site [chemical binding]; other site
326427011973	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
326427011974	Ligand Binding Site [chemical binding]; other site
326427011975	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
326427011976	MOSC domain; Region: MOSC; pfam03473
326427011977	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
326427011978	Ligand Binding Site [chemical binding]; other site
326427011979	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
326427011980	Ligand Binding Site [chemical binding]; other site
326427011981	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
326427011982	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
326427011983	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
326427011984	ligand binding site; other site
326427011985	oligomer interface; other site
326427011986	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
326427011987	dimer interface [polypeptide binding]; other site
326427011988	N-terminal domain interface [polypeptide binding]; other site
326427011989	sulfate 1 binding site; other site
326427011990	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
326427011991	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
326427011992	ligand binding site; other site
326427011993	oligomer interface; other site
326427011994	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
326427011995	dimer interface [polypeptide binding]; other site
326427011996	N-terminal domain interface [polypeptide binding]; other site
326427011997	sulfate 1 binding site; other site
326427011998	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
326427011999	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
326427012000	putative RNA binding site [nucleotide binding]; other site
326427012001	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
326427012002	S-adenosylmethionine binding site [chemical binding]; other site
326427012003	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
326427012004	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
326427012005	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
326427012006	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
326427012007	Tetramer interface [polypeptide binding]; other site
326427012008	active site
326427012009	FMN-binding site [chemical binding]; other site
326427012010	prephenate dehydrogenase; Validated; Region: PRK08507
326427012011	Prephenate dehydrogenase; Region: PDH; pfam02153
326427012012	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
326427012013	fumarylacetoacetase; Region: PLN02856
326427012014	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
326427012015	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
326427012016	glutamate carboxypeptidase; Reviewed; Region: PRK06133
326427012017	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
326427012018	metal binding site [ion binding]; metal-binding site
326427012019	dimer interface [polypeptide binding]; other site
326427012020	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
326427012021	Ferritin-like domain; Region: Ferritin; pfam00210
326427012022	ferroxidase diiron center [ion binding]; other site
326427012023	LabA_like proteins; Region: LabA_like; cd06167
326427012024	Uncharacterized conserved protein [Function unknown]; Region: COG1432
326427012025	putative metal binding site [ion binding]; other site
326427012026	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
326427012027	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701
326427012028	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701
326427012029	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
326427012030	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
326427012031	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
326427012032	putative active site pocket [active]
326427012033	dimerization interface [polypeptide binding]; other site
326427012034	putative catalytic residue [active]
326427012035	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
326427012036	Predicted ATPase [General function prediction only]; Region: COG4637
326427012037	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
326427012038	Walker A/P-loop; other site
326427012039	ATP binding site [chemical binding]; other site
326427012040	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
326427012041	ABC transporter signature motif; other site
326427012042	Walker B; other site
326427012043	D-loop; other site
326427012044	H-loop/switch region; other site
326427012045	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
326427012046	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701
326427012047	CRISPR-associated protein, Csx11 family; Region: cas_csx11; TIGR02682
326427012048	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
326427012049	AAA domain; Region: AAA_21; pfam13304
326427012050	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
326427012051	Protein of unknown function (DUF3623); Region: DUF3623; cl11843
326427012052	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
326427012053	CoA binding domain; Region: CoA_binding_2; pfam13380
326427012054	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
326427012055	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
326427012056	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
326427012057	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
326427012058	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
326427012059	DRTGG domain; Region: DRTGG; pfam07085
326427012060	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
326427012061	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
326427012062	quinone interaction residues [chemical binding]; other site
326427012063	active site
326427012064	catalytic residues [active]
326427012065	FMN binding site [chemical binding]; other site
326427012066	substrate binding site [chemical binding]; other site
326427012067	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
326427012068	active site
326427012069	dimer interface [polypeptide binding]; other site
326427012070	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
326427012071	active site
326427012072	Yip1 domain; Region: Yip1; pfam04893
326427012073	Yip1 domain; Region: Yip1; pfam04893
326427012074	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
326427012075	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
326427012076	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
326427012077	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
326427012078	DNA binding residues [nucleotide binding]
326427012079	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
326427012080	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
326427012081	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
326427012082	TM-ABC transporter signature motif; other site
326427012083	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079