-- dump date   	20140619_041009
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
340177000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
340177000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
340177000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177000004	Walker A motif; other site
340177000005	ATP binding site [chemical binding]; other site
340177000006	Walker B motif; other site
340177000007	arginine finger; other site
340177000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
340177000009	DnaA box-binding interface [nucleotide binding]; other site
340177000010	DNA polymerase III subunit beta; Provisional; Region: PRK14941
340177000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
340177000012	putative DNA binding surface [nucleotide binding]; other site
340177000013	dimer interface [polypeptide binding]; other site
340177000014	beta-clamp/clamp loader binding surface; other site
340177000015	beta-clamp/translesion DNA polymerase binding surface; other site
340177000016	recombination protein F; Reviewed; Region: recF; PRK00064
340177000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177000018	Walker A/P-loop; other site
340177000019	ATP binding site [chemical binding]; other site
340177000020	Q-loop/lid; other site
340177000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177000022	ABC transporter signature motif; other site
340177000023	Walker B; other site
340177000024	D-loop; other site
340177000025	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
340177000026	TIGR01777 family protein; Region: yfcH
340177000027	putative NAD(P) binding site [chemical binding]; other site
340177000028	putative active site [active]
340177000029	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
340177000030	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
340177000031	glutaminase active site [active]
340177000032	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
340177000033	dimer interface [polypeptide binding]; other site
340177000034	active site
340177000035	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
340177000036	dimer interface [polypeptide binding]; other site
340177000037	active site
340177000038	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
340177000039	active site
340177000040	dimer interface [polypeptide binding]; other site
340177000041	FtsH Extracellular; Region: FtsH_ext; pfam06480
340177000042	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
340177000043	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177000044	Walker B motif; other site
340177000045	arginine finger; other site
340177000046	Peptidase family M41; Region: Peptidase_M41; pfam01434
340177000047	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
340177000048	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
340177000049	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
340177000050	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
340177000051	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
340177000052	RIP metalloprotease RseP; Region: TIGR00054
340177000053	active site
340177000054	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
340177000055	protein binding site [polypeptide binding]; other site
340177000056	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
340177000057	protein binding site [polypeptide binding]; other site
340177000058	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
340177000059	putative substrate binding region [chemical binding]; other site
340177000060	peptide chain release factor 1; Validated; Region: prfA; PRK00591
340177000061	This domain is found in peptide chain release factors; Region: PCRF; smart00937
340177000062	RF-1 domain; Region: RF-1; pfam00472
340177000063	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
340177000064	camphor resistance protein CrcB; Provisional; Region: PRK14202
340177000065	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
340177000066	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
340177000067	active site
340177000068	NTP binding site [chemical binding]; other site
340177000069	metal binding triad [ion binding]; metal-binding site
340177000070	antibiotic binding site [chemical binding]; other site
340177000071	Protein of unknown function DUF86; Region: DUF86; pfam01934
340177000072	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
340177000073	active site
340177000074	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
340177000075	prephenate dehydrogenase; Validated; Region: PRK08507
340177000076	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
340177000077	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
340177000078	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340177000079	S-adenosylmethionine binding site [chemical binding]; other site
340177000080	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
340177000081	active site
340177000082	nucleophile elbow; other site
340177000083	PCRF domain; Region: PCRF; pfam03462
340177000084	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
340177000085	RF-1 domain; Region: RF-1; pfam00472
340177000086	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
340177000087	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
340177000088	active site
340177000089	metal binding site [ion binding]; metal-binding site
340177000090	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
340177000091	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
340177000092	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
340177000093	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
340177000094	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
340177000095	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
340177000096	Protein export membrane protein; Region: SecD_SecF; pfam02355
340177000097	SurA N-terminal domain; Region: SurA_N; pfam09312
340177000098	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
340177000099	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
340177000100	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
340177000101	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340177000102	ATP binding site [chemical binding]; other site
340177000103	Mg2+ binding site [ion binding]; other site
340177000104	G-X-G motif; other site
340177000105	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
340177000106	anchoring element; other site
340177000107	dimer interface [polypeptide binding]; other site
340177000108	ATP binding site [chemical binding]; other site
340177000109	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
340177000110	active site
340177000111	putative metal-binding site [ion binding]; other site
340177000112	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
340177000113	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
340177000114	dimer interface [polypeptide binding]; other site
340177000115	[2Fe-2S] cluster binding site [ion binding]; other site
340177000116	Putative addiction module component; Region: Unstab_antitox; pfam09720
340177000117	putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574
340177000118	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
340177000119	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
340177000120	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
340177000121	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
340177000122	glycyl-tRNA synthetase; Provisional; Region: PRK04173
340177000123	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
340177000124	motif 1; other site
340177000125	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
340177000126	active site
340177000127	motif 2; other site
340177000128	motif 3; other site
340177000129	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
340177000130	anticodon binding site; other site
340177000131	Uncharacterized conserved protein [Function unknown]; Region: COG1262
340177000132	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
340177000133	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
340177000134	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340177000135	putative substrate translocation pore; other site
340177000136	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
340177000137	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
340177000138	HlyD family secretion protein; Region: HlyD_3; pfam13437
340177000139	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
340177000140	AAA domain; Region: AAA_21; pfam13304
340177000141	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177000142	Walker B; other site
340177000143	D-loop; other site
340177000144	H-loop/switch region; other site
340177000145	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
340177000146	Phosphoglycerate kinase; Region: PGK; pfam00162
340177000147	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
340177000148	substrate binding site [chemical binding]; other site
340177000149	hinge regions; other site
340177000150	ADP binding site [chemical binding]; other site
340177000151	catalytic site [active]
340177000152	YceG-like family; Region: YceG; pfam02618
340177000153	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
340177000154	dimerization interface [polypeptide binding]; other site
340177000155	Chorismate mutase type II; Region: CM_2; smart00830
340177000156	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
340177000157	MraW methylase family; Region: Methyltransf_5; cl17771
340177000158	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
340177000159	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
340177000160	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
340177000161	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
340177000162	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
340177000163	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
340177000164	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
340177000165	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
340177000166	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
340177000167	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
340177000168	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
340177000169	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
340177000170	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
340177000171	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
340177000172	Mg++ binding site [ion binding]; other site
340177000173	putative catalytic motif [active]
340177000174	putative substrate binding site [chemical binding]; other site
340177000175	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
340177000176	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
340177000177	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
340177000178	cell division protein FtsW; Region: ftsW; TIGR02614
340177000179	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
340177000180	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
340177000181	active site
340177000182	homodimer interface [polypeptide binding]; other site
340177000183	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
340177000184	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
340177000185	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
340177000186	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
340177000187	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
340177000188	cell division protein FtsA; Region: ftsA; TIGR01174
340177000189	Cell division protein FtsA; Region: FtsA; smart00842
340177000190	Cell division protein FtsA; Region: FtsA; pfam14450
340177000191	cell division protein FtsZ; Validated; Region: PRK09330
340177000192	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
340177000193	nucleotide binding site [chemical binding]; other site
340177000194	SulA interaction site; other site
340177000195	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
340177000196	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
340177000197	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
340177000198	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
340177000199	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
340177000200	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
340177000201	F0F1 ATP synthase subunit A; Provisional; Region: PRK13419
340177000202	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
340177000203	ATP synthase subunit C; Region: ATP-synt_C; cl00466
340177000204	F0F1 ATP synthase subunit B; Provisional; Region: PRK14472
340177000205	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
340177000206	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
340177000207	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
340177000208	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
340177000209	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
340177000210	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
340177000211	active site
340177000212	(T/H)XGH motif; other site
340177000213	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
340177000214	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
340177000215	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
340177000216	active site
340177000217	HIGH motif; other site
340177000218	KMSK motif region; other site
340177000219	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
340177000220	tRNA binding surface [nucleotide binding]; other site
340177000221	anticodon binding site; other site
340177000222	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
340177000223	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340177000224	motif II; other site
340177000225	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
340177000226	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
340177000227	active site
340177000228	HIGH motif; other site
340177000229	dimer interface [polypeptide binding]; other site
340177000230	KMSKS motif; other site
340177000231	deoxyhypusine synthase-like protein; Provisional; Region: PRK02492
340177000232	deoxyhypusine synthase; Region: dhys; TIGR00321
340177000233	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
340177000234	active site
340177000235	intersubunit interactions; other site
340177000236	catalytic residue [active]
340177000237	DNA topoisomerase I; Validated; Region: PRK06599
340177000238	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
340177000239	active site
340177000240	interdomain interaction site; other site
340177000241	putative metal-binding site [ion binding]; other site
340177000242	nucleotide binding site [chemical binding]; other site
340177000243	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
340177000244	domain I; other site
340177000245	DNA binding groove [nucleotide binding]
340177000246	phosphate binding site [ion binding]; other site
340177000247	domain II; other site
340177000248	domain III; other site
340177000249	nucleotide binding site [chemical binding]; other site
340177000250	catalytic site [active]
340177000251	domain IV; other site
340177000252	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
340177000253	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
340177000254	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
340177000255	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
340177000256	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
340177000257	active site
340177000258	metal binding site [ion binding]; metal-binding site
340177000259	Biotin operon repressor [Transcription]; Region: BirA; COG1654
340177000260	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
340177000261	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
340177000262	biotin synthase; Region: bioB; TIGR00433
340177000263	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177000264	FeS/SAM binding site; other site
340177000265	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
340177000266	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
340177000267	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
340177000268	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
340177000269	catalytic residue [active]
340177000270	Protein of unknown function (DUF452); Region: DUF452; cl01062
340177000271	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
340177000272	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340177000273	S-adenosylmethionine binding site [chemical binding]; other site
340177000274	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
340177000275	AAA domain; Region: AAA_26; pfam13500
340177000276	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
340177000277	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
340177000278	inhibitor-cofactor binding pocket; inhibition site
340177000279	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177000280	catalytic residue [active]
340177000281	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
340177000282	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340177000283	non-specific DNA binding site [nucleotide binding]; other site
340177000284	salt bridge; other site
340177000285	sequence-specific DNA binding site [nucleotide binding]; other site
340177000286	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
340177000287	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
340177000288	Transposase; Region: DDE_Tnp_ISL3; pfam01610
340177000289	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
340177000290	DNA gyrase subunit A; Validated; Region: PRK05560
340177000291	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
340177000292	CAP-like domain; other site
340177000293	active site
340177000294	primary dimer interface [polypeptide binding]; other site
340177000295	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
340177000296	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
340177000297	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
340177000298	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
340177000299	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
340177000300	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
340177000301	CTP synthetase; Validated; Region: pyrG; PRK05380
340177000302	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
340177000303	Catalytic site [active]
340177000304	active site
340177000305	UTP binding site [chemical binding]; other site
340177000306	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
340177000307	active site
340177000308	putative oxyanion hole; other site
340177000309	catalytic triad [active]
340177000310	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
340177000311	active site
340177000312	Domain of Unknown Function (DUF3856); Region: DUF3856; pfam12968
340177000313	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177000314	binding surface
340177000315	TPR motif; other site
340177000316	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
340177000317	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
340177000318	putative active site [active]
340177000319	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
340177000320	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
340177000321	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
340177000322	dimer interface [polypeptide binding]; other site
340177000323	ssDNA binding site [nucleotide binding]; other site
340177000324	tetramer (dimer of dimers) interface [polypeptide binding]; other site
340177000325	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
340177000326	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
340177000327	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
340177000328	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
340177000329	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
340177000330	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
340177000331	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
340177000332	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
340177000333	trmE is a tRNA modification GTPase; Region: trmE; cd04164
340177000334	G1 box; other site
340177000335	GTP/Mg2+ binding site [chemical binding]; other site
340177000336	Switch I region; other site
340177000337	G2 box; other site
340177000338	Switch II region; other site
340177000339	G3 box; other site
340177000340	G4 box; other site
340177000341	G5 box; other site
340177000342	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
340177000343	HipA N-terminal domain; Region: Couple_hipA; pfam13657
340177000344	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
340177000345	HipA-like N-terminal domain; Region: HipA_N; pfam07805
340177000346	HipA-like C-terminal domain; Region: HipA_C; pfam07804
340177000347	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
340177000348	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340177000349	non-specific DNA binding site [nucleotide binding]; other site
340177000350	salt bridge; other site
340177000351	sequence-specific DNA binding site [nucleotide binding]; other site
340177000352	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
340177000353	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
340177000354	B12 binding site [chemical binding]; other site
340177000355	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
340177000356	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177000357	FeS/SAM binding site; other site
340177000358	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
340177000359	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
340177000360	catalytic residue [active]
340177000361	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
340177000362	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
340177000363	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
340177000364	catalytic site [active]
340177000365	subunit interface [polypeptide binding]; other site
340177000366	Preprotein translocase subunit; Region: YajC; pfam02699
340177000367	UGMP family protein; Validated; Region: PRK09604
340177000368	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
340177000369	MoxR-like ATPases [General function prediction only]; Region: COG0714
340177000370	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177000371	Walker A motif; other site
340177000372	ATP binding site [chemical binding]; other site
340177000373	Walker B motif; other site
340177000374	arginine finger; other site
340177000375	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
340177000376	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
340177000377	metal ion-dependent adhesion site (MIDAS); other site
340177000378	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
340177000379	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
340177000380	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177000381	FeS/SAM binding site; other site
340177000382	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
340177000383	O-methyltransferase; Region: Methyltransf_2; pfam00891
340177000384	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
340177000385	B12 binding site [chemical binding]; other site
340177000386	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
340177000387	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
340177000388	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
340177000389	P loop; other site
340177000390	Nucleotide binding site [chemical binding]; other site
340177000391	DTAP/Switch II; other site
340177000392	Switch I; other site
340177000393	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
340177000394	Flavodoxin domain; Region: Flavodoxin_5; cl17428
340177000395	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
340177000396	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
340177000397	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
340177000398	putative homodimer interface [polypeptide binding]; other site
340177000399	putative homotetramer interface [polypeptide binding]; other site
340177000400	putative allosteric switch controlling residues; other site
340177000401	putative metal binding site [ion binding]; other site
340177000402	putative homodimer-homodimer interface [polypeptide binding]; other site
340177000403	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
340177000404	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
340177000405	Protein export membrane protein; Region: SecD_SecF; cl14618
340177000406	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
340177000407	FOG: CBS domain [General function prediction only]; Region: COG0517
340177000408	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
340177000409	L-aspartate oxidase; Provisional; Region: PRK06175
340177000410	succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812
340177000411	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
340177000412	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
340177000413	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
340177000414	catalytic loop [active]
340177000415	iron binding site [ion binding]; other site
340177000416	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
340177000417	Cysteine-rich domain; Region: CCG; pfam02754
340177000418	Cysteine-rich domain; Region: CCG; pfam02754
340177000419	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
340177000420	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
340177000421	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
340177000422	substrate binding site [chemical binding]; other site
340177000423	active site
340177000424	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
340177000425	dimer interface [polypeptide binding]; other site
340177000426	active site
340177000427	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
340177000428	homopentamer interface [polypeptide binding]; other site
340177000429	active site
340177000430	Putative addiction module component; Region: Unstab_antitox; pfam09720
340177000431	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
340177000432	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
340177000433	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
340177000434	putative acyl-acceptor binding pocket; other site
340177000435	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
340177000436	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
340177000437	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177000438	catalytic residue [active]
340177000439	homoserine kinase; Provisional; Region: PRK01212
340177000440	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
340177000441	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
340177000442	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
340177000443	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
340177000444	beta subunit interaction interface [polypeptide binding]; other site
340177000445	Walker A motif; other site
340177000446	ATP binding site [chemical binding]; other site
340177000447	Walker B motif; other site
340177000448	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
340177000449	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
340177000450	core domain interface [polypeptide binding]; other site
340177000451	delta subunit interface [polypeptide binding]; other site
340177000452	epsilon subunit interface [polypeptide binding]; other site
340177000453	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
340177000454	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
340177000455	nucleotide binding site [chemical binding]; other site
340177000456	substrate binding site [chemical binding]; other site
340177000457	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
340177000458	dimer interface [polypeptide binding]; other site
340177000459	putative threonine allosteric regulatory site; other site
340177000460	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
340177000461	putative threonine allosteric regulatory site; other site
340177000462	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
340177000463	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
340177000464	competence damage-inducible protein A; Provisional; Region: PRK00549
340177000465	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
340177000466	putative MPT binding site; other site
340177000467	Competence-damaged protein; Region: CinA; pfam02464
340177000468	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177000469	AAA domain; Region: AAA_21; pfam13304
340177000470	Walker A/P-loop; other site
340177000471	ATP binding site [chemical binding]; other site
340177000472	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
340177000473	Q-loop/lid; other site
340177000474	ABC transporter signature motif; other site
340177000475	Walker B; other site
340177000476	D-loop; other site
340177000477	H-loop/switch region; other site
340177000478	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
340177000479	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340177000480	ATP binding site [chemical binding]; other site
340177000481	Mg2+ binding site [ion binding]; other site
340177000482	G-X-G motif; other site
340177000483	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
340177000484	ATP binding site [chemical binding]; other site
340177000485	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
340177000486	Transglycosylase; Region: Transgly; pfam00912
340177000487	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
340177000488	Rubredoxin; Region: Rubredoxin; pfam00301
340177000489	iron binding site [ion binding]; other site
340177000490	Uncharacterized conserved protein [Function unknown]; Region: COG1434
340177000491	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
340177000492	putative active site [active]
340177000493	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), TaA; Region: NGN_SP_TaA; cd09893
340177000494	transcriptional activator RfaH; Region: RfaH; TIGR01955
340177000495	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
340177000496	homodimer interface [polypeptide binding]; other site
340177000497	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340177000498	putative substrate translocation pore; other site
340177000499	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
340177000500	metal binding triad [ion binding]; metal-binding site
340177000501	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
340177000502	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
340177000503	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
340177000504	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
340177000505	pyruvate phosphate dikinase; Provisional; Region: PRK09279
340177000506	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
340177000507	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
340177000508	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
340177000509	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
340177000510	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
340177000511	TM-ABC transporter signature motif; other site
340177000512	zinc transporter ZupT; Provisional; Region: PRK04201
340177000513	ZIP Zinc transporter; Region: Zip; pfam02535
340177000514	TspO/MBR family; Region: TspO_MBR; pfam03073
340177000515	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177000516	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177000517	binding surface
340177000518	TPR motif; other site
340177000519	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177000520	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177000521	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177000522	binding surface
340177000523	TPR motif; other site
340177000524	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177000525	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177000526	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177000527	binding surface
340177000528	TPR motif; other site
340177000529	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
340177000530	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
340177000531	active site
340177000532	dimerization interface [polypeptide binding]; other site
340177000533	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
340177000534	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
340177000535	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
340177000536	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
340177000537	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
340177000538	active site
340177000539	putative DNA-binding cleft [nucleotide binding]; other site
340177000540	dimer interface [polypeptide binding]; other site
340177000541	hypothetical protein; Validated; Region: PRK00110
340177000542	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
340177000543	Divergent AAA domain; Region: AAA_4; pfam04326
340177000544	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
340177000545	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
340177000546	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
340177000547	conserved cys residue [active]
340177000548	Isochorismatase family; Region: Isochorismatase; pfam00857
340177000549	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
340177000550	catalytic triad [active]
340177000551	dimer interface [polypeptide binding]; other site
340177000552	conserved cis-peptide bond; other site
340177000553	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
340177000554	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
340177000555	putative acyl-acceptor binding pocket; other site
340177000556	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
340177000557	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
340177000558	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
340177000559	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
340177000560	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
340177000561	MPN+ (JAMM) motif; other site
340177000562	Zinc-binding site [ion binding]; other site
340177000563	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
340177000564	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
340177000565	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
340177000566	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
340177000567	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
340177000568	active site
340177000569	ribulose/triose binding site [chemical binding]; other site
340177000570	phosphate binding site [ion binding]; other site
340177000571	substrate (anthranilate) binding pocket [chemical binding]; other site
340177000572	product (indole) binding pocket [chemical binding]; other site
340177000573	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
340177000574	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
340177000575	substrate binding site [chemical binding]; other site
340177000576	hexamer interface [polypeptide binding]; other site
340177000577	metal binding site [ion binding]; metal-binding site
340177000578	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
340177000579	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
340177000580	Surface antigen; Region: Bac_surface_Ag; pfam01103
340177000581	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
340177000582	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
340177000583	Peptidase family M23; Region: Peptidase_M23; pfam01551
340177000584	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
340177000585	DNA polymerase I; Provisional; Region: PRK05755
340177000586	active site
340177000587	putative 5' ssDNA interaction site; other site
340177000588	metal binding site 3; metal-binding site
340177000589	metal binding site 1 [ion binding]; metal-binding site
340177000590	metal binding site 2 [ion binding]; metal-binding site
340177000591	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
340177000592	putative DNA binding site [nucleotide binding]; other site
340177000593	putative metal binding site [ion binding]; other site
340177000594	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
340177000595	active site
340177000596	catalytic site [active]
340177000597	substrate binding site [chemical binding]; other site
340177000598	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
340177000599	active site
340177000600	DNA binding site [nucleotide binding]
340177000601	catalytic site [active]
340177000602	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
340177000603	Prephenate dehydratase; Region: PDT; pfam00800
340177000604	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
340177000605	putative L-Phe binding site [chemical binding]; other site
340177000606	Fic family protein [Function unknown]; Region: COG3177
340177000607	Fic/DOC family; Region: Fic; pfam02661
340177000608	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
340177000609	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
340177000610	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177000611	Walker A motif; other site
340177000612	ATP binding site [chemical binding]; other site
340177000613	Walker B motif; other site
340177000614	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
340177000615	Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
340177000616	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
340177000617	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
340177000618	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
340177000619	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
340177000620	active site
340177000621	dimer interface [polypeptide binding]; other site
340177000622	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
340177000623	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
340177000624	active site
340177000625	FMN binding site [chemical binding]; other site
340177000626	substrate binding site [chemical binding]; other site
340177000627	3Fe-4S cluster binding site [ion binding]; other site
340177000628	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
340177000629	domain interface; other site
340177000630	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
340177000631	catalytic core [active]
340177000632	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
340177000633	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
340177000634	FMN binding site [chemical binding]; other site
340177000635	substrate binding site [chemical binding]; other site
340177000636	putative catalytic residue [active]
340177000637	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
340177000638	nucleoside/Zn binding site; other site
340177000639	dimer interface [polypeptide binding]; other site
340177000640	catalytic motif [active]
340177000641	Phosphotransferase enzyme family; Region: APH; pfam01636
340177000642	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
340177000643	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
340177000644	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
340177000645	Substrate binding site; other site
340177000646	metal-binding site
340177000647	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
340177000648	putative trimer interface [polypeptide binding]; other site
340177000649	putative CoA binding site [chemical binding]; other site
340177000650	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
340177000651	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493
340177000652	Na binding site [ion binding]; other site
340177000653	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
340177000654	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
340177000655	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
340177000656	active site
340177000657	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
340177000658	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
340177000659	nucleotide binding site [chemical binding]; other site
340177000660	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
340177000661	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
340177000662	active site
340177000663	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
340177000664	RNA methyltransferase, RsmE family; Region: TIGR00046
340177000665	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
340177000666	Transposase; Region: DDE_Tnp_ISL3; pfam01610
340177000667	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
340177000668	Domain of unknown function DUF20; Region: UPF0118; pfam01594
340177000669	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
340177000670	active site
340177000671	multimer interface [polypeptide binding]; other site
340177000672	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
340177000673	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
340177000674	catalytic triad [active]
340177000675	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
340177000676	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
340177000677	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
340177000678	catalytic residue [active]
340177000679	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
340177000680	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
340177000681	trimerization site [polypeptide binding]; other site
340177000682	active site
340177000683	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
340177000684	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14340
340177000685	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
340177000686	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177000687	FeS/SAM binding site; other site
340177000688	TRAM domain; Region: TRAM; pfam01938
340177000689	bacteriochlorophyll c synthase; Provisional; Region: PRK12392
340177000690	UbiA prenyltransferase family; Region: UbiA; pfam01040
340177000691	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
340177000692	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
340177000693	putative active site [active]
340177000694	putative metal binding site [ion binding]; other site
340177000695	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
340177000696	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
340177000697	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
340177000698	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
340177000699	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
340177000700	active site
340177000701	FOG: WD40 repeat [General function prediction only]; Region: COG2319
340177000702	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
340177000703	structural tetrad; other site
340177000704	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
340177000705	DNA-binding site [nucleotide binding]; DNA binding site
340177000706	RNA-binding motif; other site
340177000707	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
340177000708	DNA binding residues [nucleotide binding]
340177000709	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
340177000710	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
340177000711	P loop; other site
340177000712	Nucleotide binding site [chemical binding]; other site
340177000713	DTAP/Switch II; other site
340177000714	Switch I; other site
340177000715	Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043
340177000716	Chlorosome envelope protein C; Region: Chlorosome_CsmC; pfam11098
340177000717	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
340177000718	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
340177000719	P loop; other site
340177000720	Nucleotide binding site [chemical binding]; other site
340177000721	DTAP/Switch II; other site
340177000722	Switch I; other site
340177000723	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
340177000724	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
340177000725	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
340177000726	FAD binding pocket [chemical binding]; other site
340177000727	FAD binding motif [chemical binding]; other site
340177000728	phosphate binding motif [ion binding]; other site
340177000729	beta-alpha-beta structure motif; other site
340177000730	NAD binding pocket [chemical binding]; other site
340177000731	Iron coordination center [ion binding]; other site
340177000732	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
340177000733	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
340177000734	dimer interface [polypeptide binding]; other site
340177000735	ssDNA binding site [nucleotide binding]; other site
340177000736	tetramer (dimer of dimers) interface [polypeptide binding]; other site
340177000737	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
340177000738	DNA polymerase III, delta subunit; Region: holA; TIGR01128
340177000739	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
340177000740	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340177000741	NAD(P) binding site [chemical binding]; other site
340177000742	active site
340177000743	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
340177000744	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
340177000745	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
340177000746	catalytic residue [active]
340177000747	magnesium chelatase, H subunit; Region: BchH; TIGR02025
340177000748	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
340177000749	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
340177000750	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
340177000751	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340177000752	S-adenosylmethionine binding site [chemical binding]; other site
340177000753	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
340177000754	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
340177000755	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
340177000756	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177000757	FeS/SAM binding site; other site
340177000758	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
340177000759	catalytic center binding site [active]
340177000760	ATP binding site [chemical binding]; other site
340177000761	Dihydroneopterin aldolase; Region: FolB; pfam02152
340177000762	active site
340177000763	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
340177000764	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
340177000765	dimerization interface [polypeptide binding]; other site
340177000766	active site
340177000767	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14663
340177000768	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340177000769	non-specific DNA binding site [nucleotide binding]; other site
340177000770	salt bridge; other site
340177000771	sequence-specific DNA binding site [nucleotide binding]; other site
340177000772	trigger factor; Region: tig; TIGR00115
340177000773	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
340177000774	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
340177000775	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
340177000776	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
340177000777	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
340177000778	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
340177000779	putative NADP binding site [chemical binding]; other site
340177000780	putative substrate binding site [chemical binding]; other site
340177000781	active site
340177000782	recombinase A; Provisional; Region: recA; PRK09354
340177000783	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
340177000784	hexamer interface [polypeptide binding]; other site
340177000785	Walker A motif; other site
340177000786	ATP binding site [chemical binding]; other site
340177000787	Walker B motif; other site
340177000788	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
340177000789	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
340177000790	FMN binding site [chemical binding]; other site
340177000791	active site
340177000792	catalytic residues [active]
340177000793	substrate binding site [chemical binding]; other site
340177000794	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
340177000795	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
340177000796	Ion channel; Region: Ion_trans_2; pfam07885
340177000797	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
340177000798	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
340177000799	membrane-bound complex binding site; other site
340177000800	hinge residues; other site
340177000801	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
340177000802	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
340177000803	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
340177000804	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
340177000805	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
340177000806	Mechanosensitive ion channel; Region: MS_channel; pfam00924
340177000807	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
340177000808	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
340177000809	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
340177000810	trimer interface [polypeptide binding]; other site
340177000811	putative metal binding site [ion binding]; other site
340177000812	Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043
340177000813	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
340177000814	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
340177000815	Walker A/P-loop; other site
340177000816	ATP binding site [chemical binding]; other site
340177000817	Q-loop/lid; other site
340177000818	ABC transporter signature motif; other site
340177000819	Walker B; other site
340177000820	D-loop; other site
340177000821	H-loop/switch region; other site
340177000822	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340177000823	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
340177000824	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
340177000825	Ligand Binding Site [chemical binding]; other site
340177000826	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
340177000827	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
340177000828	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177000829	AAA domain; Region: AAA_23; pfam13476
340177000830	Walker A/P-loop; other site
340177000831	ATP binding site [chemical binding]; other site
340177000832	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177000833	ABC transporter signature motif; other site
340177000834	Walker B; other site
340177000835	D-loop; other site
340177000836	H-loop/switch region; other site
340177000837	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
340177000838	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
340177000839	purine monophosphate binding site [chemical binding]; other site
340177000840	dimer interface [polypeptide binding]; other site
340177000841	putative catalytic residues [active]
340177000842	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
340177000843	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
340177000844	pteridine reductase; Provisional; Region: PRK09135
340177000845	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340177000846	NAD(P) binding site [chemical binding]; other site
340177000847	active site
340177000848	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
340177000849	active site
340177000850	catalytic site [active]
340177000851	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
340177000852	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
340177000853	Walker A/P-loop; other site
340177000854	ATP binding site [chemical binding]; other site
340177000855	Q-loop/lid; other site
340177000856	ABC transporter signature motif; other site
340177000857	Walker B; other site
340177000858	D-loop; other site
340177000859	H-loop/switch region; other site
340177000860	PIN domain; Region: PIN_3; pfam13470
340177000861	HicB family; Region: HicB; pfam05534
340177000862	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
340177000863	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
340177000864	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
340177000865	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
340177000866	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
340177000867	nucleotide binding pocket [chemical binding]; other site
340177000868	K-X-D-G motif; other site
340177000869	catalytic site [active]
340177000870	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
340177000871	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
340177000872	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
340177000873	Dimer interface [polypeptide binding]; other site
340177000874	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
340177000875	Sel1-like repeats; Region: SEL1; smart00671
340177000876	Sel1-like repeats; Region: SEL1; smart00671
340177000877	Sel1-like repeats; Region: SEL1; smart00671
340177000878	Sel1-like repeats; Region: SEL1; smart00671
340177000879	Protein of unknown function (DUF2281); Region: DUF2281; pfam10047
340177000880	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
340177000881	putative active site [active]
340177000882	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
340177000883	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
340177000884	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
340177000885	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
340177000886	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
340177000887	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
340177000888	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
340177000889	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
340177000890	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177000891	FeS/SAM binding site; other site
340177000892	HemN C-terminal domain; Region: HemN_C; pfam06969
340177000893	AIR carboxylase; Region: AIRC; pfam00731
340177000894	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
340177000895	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
340177000896	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
340177000897	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
340177000898	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
340177000899	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
340177000900	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
340177000901	active site
340177000902	nucleophile elbow; other site
340177000903	Surface antigen; Region: Bac_surface_Ag; pfam01103
340177000904	stationary phase survival protein SurE; Provisional; Region: PRK13932
340177000905	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
340177000906	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
340177000907	Virulence protein [General function prediction only]; Region: COG3943
340177000908	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
340177000909	Virulence protein [General function prediction only]; Region: COG3943
340177000910	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
340177000911	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340177000912	sequence-specific DNA binding site [nucleotide binding]; other site
340177000913	salt bridge; other site
340177000914	Haem-binding domain; Region: Haem_bd; pfam14376
340177000915	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
340177000916	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
340177000917	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
340177000918	glutamine binding [chemical binding]; other site
340177000919	catalytic triad [active]
340177000920	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
340177000921	Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562
340177000922	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
340177000923	putative trimer interface [polypeptide binding]; other site
340177000924	putative CoA binding site [chemical binding]; other site
340177000925	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
340177000926	TPR repeat; Region: TPR_11; pfam13414
340177000927	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177000928	binding surface
340177000929	TPR repeat; Region: TPR_11; pfam13414
340177000930	TPR motif; other site
340177000931	TPR repeat; Region: TPR_11; pfam13414
340177000932	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177000933	binding surface
340177000934	TPR motif; other site
340177000935	TPR repeat; Region: TPR_11; pfam13414
340177000936	ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782
340177000937	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177000938	binding surface
340177000939	TPR motif; other site
340177000940	TPR repeat; Region: TPR_11; pfam13414
340177000941	ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782
340177000942	TPR repeat; Region: TPR_11; pfam13414
340177000943	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177000944	binding surface
340177000945	TPR motif; other site
340177000946	TPR repeat; Region: TPR_11; pfam13414
340177000947	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177000948	binding surface
340177000949	TPR motif; other site
340177000950	TPR repeat; Region: TPR_11; pfam13414
340177000951	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177000952	binding surface
340177000953	TPR motif; other site
340177000954	TPR repeat; Region: TPR_11; pfam13414
340177000955	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
340177000956	ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782
340177000957	Predicted permeases [General function prediction only]; Region: COG0795
340177000958	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
340177000959	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
340177000960	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
340177000961	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
340177000962	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
340177000963	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
340177000964	putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574
340177000965	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
340177000966	Domain of unknown function (DUF955); Region: DUF955; cl01076
340177000967	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
340177000968	AIPR protein; Region: AIPR; pfam10592
340177000969	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
340177000970	excinuclease ABC subunit B; Provisional; Region: PRK05298
340177000971	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340177000972	ATP binding site [chemical binding]; other site
340177000973	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340177000974	nucleotide binding region [chemical binding]; other site
340177000975	ATP-binding site [chemical binding]; other site
340177000976	Ultra-violet resistance protein B; Region: UvrB; pfam12344
340177000977	UvrB/uvrC motif; Region: UVR; pfam02151
340177000978	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
340177000979	metal-binding site [ion binding]
340177000980	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
340177000981	putative metal binding site [ion binding]; other site
340177000982	Uncharacterized conserved protein [Function unknown]; Region: COG1432
340177000983	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
340177000984	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
340177000985	Citrate synthase; Region: Citrate_synt; pfam00285
340177000986	oxalacetate binding site [chemical binding]; other site
340177000987	citrylCoA binding site [chemical binding]; other site
340177000988	coenzyme A binding site [chemical binding]; other site
340177000989	catalytic triad [active]
340177000990	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
340177000991	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
340177000992	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
340177000993	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
340177000994	Ligand binding site; other site
340177000995	oligomer interface; other site
340177000996	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
340177000997	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
340177000998	generic binding surface II; other site
340177000999	generic binding surface I; other site
340177001000	ribonuclease E; Reviewed; Region: rne; PRK10811
340177001001	Sporulation related domain; Region: SPOR; pfam05036
340177001002	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
340177001003	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
340177001004	Protein of unknown function DUF262; Region: DUF262; pfam03235
340177001005	Uncharacterized conserved protein [Function unknown]; Region: COG1479
340177001006	Protein of unknown function DUF262; Region: DUF262; pfam03235
340177001007	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
340177001008	ribosome recycling factor; Reviewed; Region: frr; PRK00083
340177001009	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
340177001010	hinge region; other site
340177001011	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
340177001012	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
340177001013	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
340177001014	generic binding surface II; other site
340177001015	ssDNA binding site; other site
340177001016	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340177001017	ATP binding site [chemical binding]; other site
340177001018	putative Mg++ binding site [ion binding]; other site
340177001019	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340177001020	nucleotide binding region [chemical binding]; other site
340177001021	ATP-binding site [chemical binding]; other site
340177001022	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
340177001023	GTPase RsgA; Reviewed; Region: PRK00098
340177001024	RNA binding site [nucleotide binding]; other site
340177001025	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
340177001026	GTPase/Zn-binding domain interface [polypeptide binding]; other site
340177001027	GTP/Mg2+ binding site [chemical binding]; other site
340177001028	G4 box; other site
340177001029	G5 box; other site
340177001030	G1 box; other site
340177001031	Switch I region; other site
340177001032	G2 box; other site
340177001033	G3 box; other site
340177001034	Switch II region; other site
340177001035	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
340177001036	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
340177001037	NAD(P) binding site [chemical binding]; other site
340177001038	catalytic residues [active]
340177001039	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
340177001040	active site
340177001041	NTP binding site [chemical binding]; other site
340177001042	metal binding triad [ion binding]; metal-binding site
340177001043	antibiotic binding site [chemical binding]; other site
340177001044	DNA methylase; Region: N6_N4_Mtase; cl17433
340177001045	MjaII restriction endonuclease; Region: RE_MjaII; pfam09520
340177001046	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
340177001047	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
340177001048	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
340177001049	ABC transporter; Region: ABC_tran_2; pfam12848
340177001050	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
340177001051	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
340177001052	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
340177001053	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
340177001054	HlyD family secretion protein; Region: HlyD_3; pfam13437
340177001055	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
340177001056	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
340177001057	Walker A/P-loop; other site
340177001058	ATP binding site [chemical binding]; other site
340177001059	Q-loop/lid; other site
340177001060	ABC transporter signature motif; other site
340177001061	Walker B; other site
340177001062	D-loop; other site
340177001063	H-loop/switch region; other site
340177001064	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
340177001065	FtsX-like permease family; Region: FtsX; pfam02687
340177001066	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
340177001067	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
340177001068	CoA-ligase; Region: Ligase_CoA; pfam00549
340177001069	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
340177001070	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
340177001071	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
340177001072	DXD motif; other site
340177001073	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177001074	binding surface
340177001075	Tetratricopeptide repeat; Region: TPR_16; pfam13432
340177001076	TPR motif; other site
340177001077	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177001078	binding surface
340177001079	TPR motif; other site
340177001080	TPR repeat; Region: TPR_11; pfam13414
340177001081	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177001082	binding surface
340177001083	TPR motif; other site
340177001084	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177001085	binding surface
340177001086	TPR motif; other site
340177001087	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
340177001088	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
340177001089	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
340177001090	Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224
340177001091	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
340177001092	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
340177001093	Ligand binding site; other site
340177001094	Putative Catalytic site; other site
340177001095	DXD motif; other site
340177001096	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
340177001097	elongation factor G; Reviewed; Region: PRK12740
340177001098	G1 box; other site
340177001099	putative GEF interaction site [polypeptide binding]; other site
340177001100	GTP/Mg2+ binding site [chemical binding]; other site
340177001101	Switch I region; other site
340177001102	G2 box; other site
340177001103	G3 box; other site
340177001104	Switch II region; other site
340177001105	G4 box; other site
340177001106	G5 box; other site
340177001107	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
340177001108	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
340177001109	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
340177001110	enolase; Provisional; Region: eno; PRK00077
340177001111	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
340177001112	dimer interface [polypeptide binding]; other site
340177001113	metal binding site [ion binding]; metal-binding site
340177001114	substrate binding pocket [chemical binding]; other site
340177001115	Septum formation initiator; Region: DivIC; pfam04977
340177001116	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
340177001117	GcpE protein; Region: GcpE; pfam04551
340177001118	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
340177001119	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
340177001120	classical (c) SDRs; Region: SDR_c; cd05233
340177001121	NAD(P) binding site [chemical binding]; other site
340177001122	active site
340177001123	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
340177001124	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
340177001125	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
340177001126	putative homodimer interface [polypeptide binding]; other site
340177001127	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
340177001128	heterodimer interface [polypeptide binding]; other site
340177001129	homodimer interface [polypeptide binding]; other site
340177001130	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
340177001131	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
340177001132	23S rRNA interface [nucleotide binding]; other site
340177001133	L7/L12 interface [polypeptide binding]; other site
340177001134	putative thiostrepton binding site; other site
340177001135	L25 interface [polypeptide binding]; other site
340177001136	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
340177001137	mRNA/rRNA interface [nucleotide binding]; other site
340177001138	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
340177001139	23S rRNA interface [nucleotide binding]; other site
340177001140	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
340177001141	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
340177001142	L11 interface [polypeptide binding]; other site
340177001143	putative EF-Tu interaction site [polypeptide binding]; other site
340177001144	putative EF-G interaction site [polypeptide binding]; other site
340177001145	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
340177001146	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
340177001147	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
340177001148	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
340177001149	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
340177001150	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
340177001151	RPB3 interaction site [polypeptide binding]; other site
340177001152	RPB1 interaction site [polypeptide binding]; other site
340177001153	RPB11 interaction site [polypeptide binding]; other site
340177001154	RPB10 interaction site [polypeptide binding]; other site
340177001155	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
340177001156	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
340177001157	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
340177001158	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
340177001159	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
340177001160	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
340177001161	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
340177001162	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
340177001163	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
340177001164	DNA binding site [nucleotide binding]
340177001165	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
340177001166	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
340177001167	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
340177001168	ATP-grasp domain; Region: ATP-grasp_4; cl17255
340177001169	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
340177001170	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
340177001171	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
340177001172	carboxyltransferase (CT) interaction site; other site
340177001173	biotinylation site [posttranslational modification]; other site
340177001174	elongation factor P; Validated; Region: PRK00529
340177001175	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
340177001176	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
340177001177	RNA binding site [nucleotide binding]; other site
340177001178	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
340177001179	RNA binding site [nucleotide binding]; other site
340177001180	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
340177001181	IHF - DNA interface [nucleotide binding]; other site
340177001182	IHF dimer interface [polypeptide binding]; other site
340177001183	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
340177001184	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
340177001185	NACHT domain; Region: NACHT; pfam05729
340177001186	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
340177001187	Uncharacterized conserved protein [Function unknown]; Region: COG1262
340177001188	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
340177001189	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
340177001190	TPP-binding site [chemical binding]; other site
340177001191	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
340177001192	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
340177001193	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
340177001194	PYR/PP interface [polypeptide binding]; other site
340177001195	TPP binding site [chemical binding]; other site
340177001196	dimer interface [polypeptide binding]; other site
340177001197	substrate binding site [chemical binding]; other site
340177001198	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
340177001199	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
340177001200	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
340177001201	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
340177001202	motif 1; other site
340177001203	active site
340177001204	motif 2; other site
340177001205	motif 3; other site
340177001206	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
340177001207	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
340177001208	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
340177001209	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
340177001210	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
340177001211	GTP cyclohydrolase I; Provisional; Region: PLN03044
340177001212	homodecamer interface [polypeptide binding]; other site
340177001213	active site
340177001214	putative catalytic site residues [active]
340177001215	zinc binding site [ion binding]; other site
340177001216	GTP-CH-I/GFRP interaction surface; other site
340177001217	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
340177001218	active site
340177001219	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
340177001220	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177001221	Walker A/P-loop; other site
340177001222	ATP binding site [chemical binding]; other site
340177001223	Q-loop/lid; other site
340177001224	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
340177001225	ABC transporter signature motif; other site
340177001226	Walker B; other site
340177001227	D-loop; other site
340177001228	ABC transporter; Region: ABC_tran_2; pfam12848
340177001229	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
340177001230	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
340177001231	Predicted helicase [General function prediction only]; Region: COG4889
340177001232	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
340177001233	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
340177001234	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
340177001235	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
340177001236	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
340177001237	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340177001238	ATP binding site [chemical binding]; other site
340177001239	putative Mg++ binding site [ion binding]; other site
340177001240	nucleotide binding region [chemical binding]; other site
340177001241	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
340177001242	ATP-binding site [chemical binding]; other site
340177001243	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340177001244	non-specific DNA binding site [nucleotide binding]; other site
340177001245	salt bridge; other site
340177001246	sequence-specific DNA binding site [nucleotide binding]; other site
340177001247	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
340177001248	ThiC-associated domain; Region: ThiC-associated; pfam13667
340177001249	ThiC family; Region: ThiC; pfam01964
340177001250	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
340177001251	classical (c) SDRs; Region: SDR_c; cd05233
340177001252	NAD(P) binding site [chemical binding]; other site
340177001253	active site
340177001254	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
340177001255	NADH(P)-binding; Region: NAD_binding_10; pfam13460
340177001256	NAD(P) binding site [chemical binding]; other site
340177001257	putative active site [active]
340177001258	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
340177001259	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
340177001260	dimer interface [polypeptide binding]; other site
340177001261	active site
340177001262	heme binding site [chemical binding]; other site
340177001263	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
340177001264	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
340177001265	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
340177001266	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
340177001267	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
340177001268	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
340177001269	DNA binding residues [nucleotide binding]
340177001270	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
340177001271	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
340177001272	active site
340177001273	HIGH motif; other site
340177001274	nucleotide binding site [chemical binding]; other site
340177001275	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
340177001276	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
340177001277	active site
340177001278	KMSKS motif; other site
340177001279	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
340177001280	tRNA binding surface [nucleotide binding]; other site
340177001281	anticodon binding site; other site
340177001282	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
340177001283	Clp protease; Region: CLP_protease; pfam00574
340177001284	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
340177001285	oligomer interface [polypeptide binding]; other site
340177001286	active site residues [active]
340177001287	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
340177001288	FtsH Extracellular; Region: FtsH_ext; pfam06480
340177001289	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
340177001290	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177001291	Walker B motif; other site
340177001292	arginine finger; other site
340177001293	Peptidase family M41; Region: Peptidase_M41; pfam01434
340177001294	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
340177001295	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
340177001296	HIGH motif; other site
340177001297	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
340177001298	active site
340177001299	KMSKS motif; other site
340177001300	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
340177001301	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
340177001302	iron-sulfur cluster [ion binding]; other site
340177001303	[2Fe-2S] cluster binding site [ion binding]; other site
340177001304	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
340177001305	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
340177001306	heme bL binding site [chemical binding]; other site
340177001307	interchain domain interface [polypeptide binding]; other site
340177001308	intrachain domain interface; other site
340177001309	heme bH binding site [chemical binding]; other site
340177001310	Qo binding site; other site
340177001311	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
340177001312	interchain domain interface [polypeptide binding]; other site
340177001313	intrachain domain interface; other site
340177001314	Qi binding site; other site
340177001315	Qo binding site; other site
340177001316	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
340177001317	Low molecular weight phosphatase family; Region: LMWPc; cd00115
340177001318	active site
340177001319	Predicted permeases [General function prediction only]; Region: COG0701
340177001320	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
340177001321	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
340177001322	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family; Region: Fer4_NifH; pfam00142
340177001323	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
340177001324	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
340177001325	DNA binding residues [nucleotide binding]
340177001326	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
340177001327	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
340177001328	putative NAD(P) binding site [chemical binding]; other site
340177001329	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
340177001330	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
340177001331	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
340177001332	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
340177001333	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
340177001334	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
340177001335	active site
340177001336	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
340177001337	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
340177001338	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
340177001339	active site
340177001340	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
340177001341	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
340177001342	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
340177001343	Low molecular weight phosphatase family; Region: LMWPc; cd00115
340177001344	active site
340177001345	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
340177001346	Sodium Bile acid symporter family; Region: SBF; cl17470
340177001347	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
340177001348	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
340177001349	phosphoserine phosphatase SerB; Region: serB; TIGR00338
340177001350	Acid Phosphatase; Region: Acid_PPase; cl17256
340177001351	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340177001352	motif II; other site
340177001353	MOSC domain; Region: MOSC; pfam03473
340177001354	Helix-turn-helix domain; Region: HTH_18; pfam12833
340177001355	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
340177001356	molybdenum transport protein ModD; Provisional; Region: PRK06096
340177001357	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
340177001358	dimerization interface [polypeptide binding]; other site
340177001359	active site
340177001360	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
340177001361	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
340177001362	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
340177001363	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340177001364	dimer interface [polypeptide binding]; other site
340177001365	conserved gate region; other site
340177001366	putative PBP binding loops; other site
340177001367	ABC-ATPase subunit interface; other site
340177001368	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177001369	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
340177001370	Walker A/P-loop; other site
340177001371	ATP binding site [chemical binding]; other site
340177001372	Q-loop/lid; other site
340177001373	ABC transporter signature motif; other site
340177001374	Walker B; other site
340177001375	D-loop; other site
340177001376	H-loop/switch region; other site
340177001377	TOBE domain; Region: TOBE; cl01440
340177001378	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
340177001379	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
340177001380	helix-hairpin-helix signature motif; other site
340177001381	substrate binding pocket [chemical binding]; other site
340177001382	active site
340177001383	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
340177001384	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
340177001385	putative RNA binding site [nucleotide binding]; other site
340177001386	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
340177001387	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340177001388	motif II; other site
340177001389	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
340177001390	AAA domain; Region: AAA_23; pfam13476
340177001391	Walker A/P-loop; other site
340177001392	ATP binding site [chemical binding]; other site
340177001393	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
340177001394	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
340177001395	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
340177001396	Q-loop/lid; other site
340177001397	ABC transporter signature motif; other site
340177001398	Walker B; other site
340177001399	D-loop; other site
340177001400	H-loop/switch region; other site
340177001401	dihydropteroate synthase; Region: DHPS; TIGR01496
340177001402	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
340177001403	substrate binding pocket [chemical binding]; other site
340177001404	dimer interface [polypeptide binding]; other site
340177001405	inhibitor binding site; inhibition site
340177001406	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
340177001407	active site
340177001408	aminodeoxychorismate synthase; Provisional; Region: PRK07508
340177001409	chorismate binding enzyme; Region: Chorismate_bind; cl10555
340177001410	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
340177001411	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
340177001412	substrate-cofactor binding pocket; other site
340177001413	homodimer interface [polypeptide binding]; other site
340177001414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177001415	catalytic residue [active]
340177001416	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
340177001417	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
340177001418	enterobactin exporter EntS; Provisional; Region: PRK10489
340177001419	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340177001420	putative substrate translocation pore; other site
340177001421	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340177001422	dimerization interface [polypeptide binding]; other site
340177001423	putative DNA binding site [nucleotide binding]; other site
340177001424	putative Zn2+ binding site [ion binding]; other site
340177001425	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
340177001426	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
340177001427	PemK-like protein; Region: PemK; cl00995
340177001428	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
340177001429	putative active site [active]
340177001430	putative metal binding site [ion binding]; other site
340177001431	polyphosphate kinase; Provisional; Region: PRK05443
340177001432	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
340177001433	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
340177001434	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
340177001435	putative domain interface [polypeptide binding]; other site
340177001436	putative active site [active]
340177001437	catalytic site [active]
340177001438	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
340177001439	putative domain interface [polypeptide binding]; other site
340177001440	putative active site [active]
340177001441	catalytic site [active]
340177001442	PhoU domain; Region: PhoU; pfam01895
340177001443	pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285
340177001444	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
340177001445	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
340177001446	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
340177001447	active site
340177001448	phosphorylation site [posttranslational modification]
340177001449	intermolecular recognition site; other site
340177001450	dimerization interface [polypeptide binding]; other site
340177001451	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
340177001452	DNA binding site [nucleotide binding]
340177001453	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
340177001454	dimerization interface [polypeptide binding]; other site
340177001455	PAS domain; Region: PAS; smart00091
340177001456	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
340177001457	putative active site [active]
340177001458	heme pocket [chemical binding]; other site
340177001459	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
340177001460	dimer interface [polypeptide binding]; other site
340177001461	phosphorylation site [posttranslational modification]
340177001462	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340177001463	ATP binding site [chemical binding]; other site
340177001464	Mg2+ binding site [ion binding]; other site
340177001465	G-X-G motif; other site
340177001466	Predicted permeases [General function prediction only]; Region: COG0795
340177001467	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
340177001468	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
340177001469	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
340177001470	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
340177001471	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
340177001472	dimerization interface [polypeptide binding]; other site
340177001473	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
340177001474	dimer interface [polypeptide binding]; other site
340177001475	phosphorylation site [posttranslational modification]
340177001476	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340177001477	ATP binding site [chemical binding]; other site
340177001478	Mg2+ binding site [ion binding]; other site
340177001479	G-X-G motif; other site
340177001480	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
340177001481	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
340177001482	active site
340177001483	phosphorylation site [posttranslational modification]
340177001484	intermolecular recognition site; other site
340177001485	dimerization interface [polypeptide binding]; other site
340177001486	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
340177001487	DNA binding site [nucleotide binding]
340177001488	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
340177001489	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
340177001490	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
340177001491	substrate binding site [chemical binding]; other site
340177001492	glutamase interaction surface [polypeptide binding]; other site
340177001493	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
340177001494	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
340177001495	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
340177001496	dimer interface [polypeptide binding]; other site
340177001497	substrate binding site [chemical binding]; other site
340177001498	metal binding sites [ion binding]; metal-binding site
340177001499	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
340177001500	putative ADP-binding pocket [chemical binding]; other site
340177001501	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340177001502	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
340177001503	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
340177001504	inhibitor-cofactor binding pocket; inhibition site
340177001505	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177001506	catalytic residue [active]
340177001507	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
340177001508	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
340177001509	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
340177001510	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
340177001511	putative active site [active]
340177001512	homotetrameric interface [polypeptide binding]; other site
340177001513	metal binding site [ion binding]; metal-binding site
340177001514	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
340177001515	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
340177001516	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177001517	catalytic residue [active]
340177001518	Fic family protein [Function unknown]; Region: COG3177
340177001519	Fic/DOC family; Region: Fic; pfam02661
340177001520	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
340177001521	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
340177001522	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
340177001523	Walker A/P-loop; other site
340177001524	ATP binding site [chemical binding]; other site
340177001525	Q-loop/lid; other site
340177001526	ABC transporter signature motif; other site
340177001527	Walker B; other site
340177001528	D-loop; other site
340177001529	H-loop/switch region; other site
340177001530	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
340177001531	This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase...; Region: PGM_like4; cd05803
340177001532	active site
340177001533	substrate binding site [chemical binding]; other site
340177001534	metal binding site [ion binding]; metal-binding site
340177001535	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
340177001536	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
340177001537	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
340177001538	RuvA N terminal domain; Region: RuvA_N; pfam01330
340177001539	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
340177001540	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
340177001541	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
340177001542	transcription termination factor Rho; Provisional; Region: rho; PRK09376
340177001543	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
340177001544	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
340177001545	RNA binding site [nucleotide binding]; other site
340177001546	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
340177001547	multimer interface [polypeptide binding]; other site
340177001548	Walker A motif; other site
340177001549	ATP binding site [chemical binding]; other site
340177001550	Walker B motif; other site
340177001551	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
340177001552	Ligand binding site [chemical binding]; other site
340177001553	Electron transfer flavoprotein domain; Region: ETF; pfam01012
340177001554	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
340177001555	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
340177001556	Ligand Binding Site [chemical binding]; other site
340177001557	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
340177001558	Bifunctional nuclease; Region: DNase-RNase; pfam02577
340177001559	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
340177001560	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
340177001561	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
340177001562	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
340177001563	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
340177001564	Surface antigen; Region: Bac_surface_Ag; pfam01103
340177001565	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
340177001566	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
340177001567	catalytic residue [active]
340177001568	putative FPP diphosphate  binding site; other site
340177001569	putative FPP binding hydrophobic cleft; other site
340177001570	dimer interface [polypeptide binding]; other site
340177001571	putative IPP diphosphate binding site; other site
340177001572	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
340177001573	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
340177001574	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
340177001575	CoA binding domain; Region: CoA_binding; smart00881
340177001576	CoA-ligase; Region: Ligase_CoA; pfam00549
340177001577	KpsF/GutQ family protein; Region: kpsF; TIGR00393
340177001578	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
340177001579	putative active site [active]
340177001580	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
340177001581	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
340177001582	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
340177001583	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
340177001584	dimer interface [polypeptide binding]; other site
340177001585	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
340177001586	dimer interface [polypeptide binding]; other site
340177001587	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
340177001588	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
340177001589	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
340177001590	DNA binding residues [nucleotide binding]
340177001591	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
340177001592	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
340177001593	active site
340177001594	substrate binding site [chemical binding]; other site
340177001595	metal binding site [ion binding]; metal-binding site
340177001596	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
340177001597	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
340177001598	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
340177001599	Beta-lactamase; Region: Beta-lactamase; pfam00144
340177001600	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
340177001601	mce related protein; Region: MCE; pfam02470
340177001602	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
340177001603	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
340177001604	Walker A/P-loop; other site
340177001605	ATP binding site [chemical binding]; other site
340177001606	Q-loop/lid; other site
340177001607	ABC transporter signature motif; other site
340177001608	Walker B; other site
340177001609	D-loop; other site
340177001610	H-loop/switch region; other site
340177001611	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
340177001612	Permease; Region: Permease; pfam02405
340177001613	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
340177001614	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
340177001615	active site
340177001616	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
340177001617	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
340177001618	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
340177001619	active site
340177001620	dimerization interface [polypeptide binding]; other site
340177001621	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
340177001622	active site
340177001623	hydrophilic channel; other site
340177001624	dimerization interface [polypeptide binding]; other site
340177001625	catalytic residues [active]
340177001626	active site lid [active]
340177001627	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
340177001628	AAA ATPase domain; Region: AAA_16; pfam13191
340177001629	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340177001630	putative DNA binding site [nucleotide binding]; other site
340177001631	putative Zn2+ binding site [ion binding]; other site
340177001632	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177001633	binding surface
340177001634	TPR motif; other site
340177001635	TPR repeat; Region: TPR_11; pfam13414
340177001636	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177001637	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177001638	binding surface
340177001639	TPR motif; other site
340177001640	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
340177001641	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
340177001642	putative active site [active]
340177001643	substrate binding site [chemical binding]; other site
340177001644	putative cosubstrate binding site; other site
340177001645	catalytic site [active]
340177001646	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
340177001647	substrate binding site [chemical binding]; other site
340177001648	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
340177001649	active site
340177001650	catalytic residues [active]
340177001651	metal binding site [ion binding]; metal-binding site
340177001652	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
340177001653	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
340177001654	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
340177001655	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
340177001656	active site
340177001657	GTP-binding protein LepA; Provisional; Region: PRK05433
340177001658	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
340177001659	G1 box; other site
340177001660	putative GEF interaction site [polypeptide binding]; other site
340177001661	GTP/Mg2+ binding site [chemical binding]; other site
340177001662	Switch I region; other site
340177001663	G2 box; other site
340177001664	G3 box; other site
340177001665	Switch II region; other site
340177001666	G4 box; other site
340177001667	G5 box; other site
340177001668	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
340177001669	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
340177001670	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
340177001671	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
340177001672	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
340177001673	Catalytic site [active]
340177001674	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
340177001675	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
340177001676	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
340177001677	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
340177001678	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
340177001679	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
340177001680	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
340177001681	protein binding site [polypeptide binding]; other site
340177001682	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
340177001683	protein binding site [polypeptide binding]; other site
340177001684	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
340177001685	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
340177001686	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
340177001687	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
340177001688	triosephosphate isomerase; Provisional; Region: PRK14565
340177001689	substrate binding site [chemical binding]; other site
340177001690	dimer interface [polypeptide binding]; other site
340177001691	catalytic triad [active]
340177001692	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
340177001693	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
340177001694	Walker A/P-loop; other site
340177001695	ATP binding site [chemical binding]; other site
340177001696	Q-loop/lid; other site
340177001697	ABC transporter signature motif; other site
340177001698	Walker B; other site
340177001699	D-loop; other site
340177001700	H-loop/switch region; other site
340177001701	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
340177001702	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
340177001703	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340177001704	dimer interface [polypeptide binding]; other site
340177001705	conserved gate region; other site
340177001706	putative PBP binding loops; other site
340177001707	ABC-ATPase subunit interface; other site
340177001708	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
340177001709	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
340177001710	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340177001711	dimer interface [polypeptide binding]; other site
340177001712	conserved gate region; other site
340177001713	putative PBP binding loops; other site
340177001714	ABC-ATPase subunit interface; other site
340177001715	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
340177001716	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
340177001717	acetylornithine aminotransferase; Provisional; Region: PRK02627
340177001718	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
340177001719	inhibitor-cofactor binding pocket; inhibition site
340177001720	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177001721	catalytic residue [active]
340177001722	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
340177001723	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
340177001724	active site
340177001725	substrate binding site [chemical binding]; other site
340177001726	cosubstrate binding site; other site
340177001727	catalytic site [active]
340177001728	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
340177001729	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177001730	FeS/SAM binding site; other site
340177001731	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
340177001732	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
340177001733	Ligand binding site; other site
340177001734	Putative Catalytic site; other site
340177001735	DXD motif; other site
340177001736	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
340177001737	G3 box; other site
340177001738	Switch II region; other site
340177001739	G4 box; other site
340177001740	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
340177001741	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
340177001742	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
340177001743	G1 box; other site
340177001744	GTP/Mg2+ binding site [chemical binding]; other site
340177001745	G2 box; other site
340177001746	Switch I region; other site
340177001747	G3 box; other site
340177001748	Switch II region; other site
340177001749	G4 box; other site
340177001750	G5 box; other site
340177001751	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177001752	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
340177001753	Walker A motif; other site
340177001754	ATP binding site [chemical binding]; other site
340177001755	Walker B motif; other site
340177001756	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
340177001757	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
340177001758	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
340177001759	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
340177001760	Zn2+ binding site [ion binding]; other site
340177001761	Mg2+ binding site [ion binding]; other site
340177001762	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
340177001763	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
340177001764	substrate binding site; other site
340177001765	tetramer interface; other site
340177001766	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
340177001767	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
340177001768	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
340177001769	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
340177001770	NADP binding site [chemical binding]; other site
340177001771	active site
340177001772	putative substrate binding site [chemical binding]; other site
340177001773	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
340177001774	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
340177001775	NAD binding site [chemical binding]; other site
340177001776	substrate binding site [chemical binding]; other site
340177001777	homodimer interface [polypeptide binding]; other site
340177001778	active site
340177001779	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
340177001780	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
340177001781	NAD binding site [chemical binding]; other site
340177001782	homodimer interface [polypeptide binding]; other site
340177001783	active site
340177001784	substrate binding site [chemical binding]; other site
340177001785	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
340177001786	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
340177001787	Substrate binding site; other site
340177001788	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
340177001789	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
340177001790	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
340177001791	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
340177001792	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
340177001793	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
340177001794	active site
340177001795	HIGH motif; other site
340177001796	nucleotide binding site [chemical binding]; other site
340177001797	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
340177001798	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
340177001799	active site
340177001800	KMSKS motif; other site
340177001801	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
340177001802	tRNA binding surface [nucleotide binding]; other site
340177001803	anticodon binding site; other site
340177001804	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
340177001805	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
340177001806	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
340177001807	active site
340177001808	tetramer interface [polypeptide binding]; other site
340177001809	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
340177001810	active site
340177001811	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
340177001812	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
340177001813	endonuclease IV; Provisional; Region: PRK01060
340177001814	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
340177001815	AP (apurinic/apyrimidinic) site pocket; other site
340177001816	DNA interaction; other site
340177001817	Metal-binding active site; metal-binding site
340177001818	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
340177001819	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
340177001820	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001821	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001822	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001823	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001824	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001825	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001826	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001827	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001828	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001829	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001830	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001831	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001832	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001833	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001834	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001835	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001836	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001837	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001838	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001839	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001840	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001841	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001842	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001843	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001844	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001845	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001846	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177001847	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
340177001848	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
340177001849	HupF/HypC family; Region: HupF_HypC; pfam01455
340177001850	Acylphosphatase; Region: Acylphosphatase; pfam00708
340177001851	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
340177001852	HypF finger; Region: zf-HYPF; pfam07503
340177001853	HypF finger; Region: zf-HYPF; pfam07503
340177001854	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
340177001855	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
340177001856	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
340177001857	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
340177001858	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
340177001859	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
340177001860	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
340177001861	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
340177001862	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
340177001863	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
340177001864	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
340177001865	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
340177001866	FAD binding pocket [chemical binding]; other site
340177001867	FAD binding motif [chemical binding]; other site
340177001868	phosphate binding motif [ion binding]; other site
340177001869	beta-alpha-beta structure motif; other site
340177001870	NAD binding pocket [chemical binding]; other site
340177001871	Iron coordination center [ion binding]; other site
340177001872	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
340177001873	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
340177001874	putative active site [active]
340177001875	oxyanion strand; other site
340177001876	catalytic triad [active]
340177001877	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
340177001878	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
340177001879	catalytic residues [active]
340177001880	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
340177001881	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
340177001882	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
340177001883	RNA binding surface [nucleotide binding]; other site
340177001884	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
340177001885	active site
340177001886	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
340177001887	sulfation-dependent quorum factor, Ax21 family; Region: Y_sulf_Ax21; TIGR04273
340177001888	sulfation-dependent quorum factor, Ax21 family; Region: Y_sulf_Ax21; TIGR04273
340177001889	putative protease; Provisional; Region: PRK15452
340177001890	Peptidase family U32; Region: Peptidase_U32; pfam01136
340177001891	DNA primase, catalytic core; Region: dnaG; TIGR01391
340177001892	CHC2 zinc finger; Region: zf-CHC2; pfam01807
340177001893	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
340177001894	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
340177001895	active site
340177001896	metal binding site [ion binding]; metal-binding site
340177001897	interdomain interaction site; other site
340177001898	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
340177001899	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
340177001900	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
340177001901	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
340177001902	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
340177001903	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
340177001904	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
340177001905	Transposase IS200 like; Region: Y1_Tnp; cl00848
340177001906	Transposase IS200 like; Region: Y1_Tnp; cl00848
340177001907	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
340177001908	dimerization interface [polypeptide binding]; other site
340177001909	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
340177001910	ATP binding site [chemical binding]; other site
340177001911	cobalt transport protein CbiM; Validated; Region: PRK06265
340177001912	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
340177001913	PDGLE domain; Region: PDGLE; pfam13190
340177001914	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
340177001915	HlyD family secretion protein; Region: HlyD_3; pfam13437
340177001916	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
340177001917	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
340177001918	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340177001919	S-adenosylmethionine binding site [chemical binding]; other site
340177001920	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
340177001921	PAS domain; Region: PAS_9; pfam13426
340177001922	putative active site [active]
340177001923	heme pocket [chemical binding]; other site
340177001924	Predicted transcriptional regulators [Transcription]; Region: COG1695
340177001925	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
340177001926	CheB methylesterase; Region: CheB_methylest; pfam01339
340177001927	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
340177001928	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
340177001929	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
340177001930	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473
340177001931	PAS domain; Region: PAS_10; pfam13596
340177001932	PAS fold; Region: PAS; pfam00989
340177001933	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
340177001934	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
340177001935	IHF dimer interface [polypeptide binding]; other site
340177001936	IHF - DNA interface [nucleotide binding]; other site
340177001937	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
340177001938	active site
340177001939	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
340177001940	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
340177001941	rod shape-determining protein MreC; Provisional; Region: PRK13922
340177001942	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
340177001943	GTPase Era; Reviewed; Region: era; PRK00089
340177001944	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
340177001945	G1 box; other site
340177001946	GTP/Mg2+ binding site [chemical binding]; other site
340177001947	Switch I region; other site
340177001948	G2 box; other site
340177001949	Switch II region; other site
340177001950	G3 box; other site
340177001951	G4 box; other site
340177001952	G5 box; other site
340177001953	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
340177001954	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
340177001955	RNA binding site [nucleotide binding]; other site
340177001956	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
340177001957	RNA binding site [nucleotide binding]; other site
340177001958	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
340177001959	RNA binding site [nucleotide binding]; other site
340177001960	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
340177001961	RNA binding site [nucleotide binding]; other site
340177001962	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
340177001963	RNA binding site [nucleotide binding]; other site
340177001964	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
340177001965	RNA binding site [nucleotide binding]; other site
340177001966	cytidylate kinase; Provisional; Region: cmk; PRK00023
340177001967	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
340177001968	CMP-binding site; other site
340177001969	The sites determining sugar specificity; other site
340177001970	GTP-binding protein YchF; Reviewed; Region: PRK09601
340177001971	YchF GTPase; Region: YchF; cd01900
340177001972	G1 box; other site
340177001973	GTP/Mg2+ binding site [chemical binding]; other site
340177001974	Switch I region; other site
340177001975	G2 box; other site
340177001976	Switch II region; other site
340177001977	G3 box; other site
340177001978	G4 box; other site
340177001979	G5 box; other site
340177001980	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
340177001981	glutamate racemase; Provisional; Region: PRK00865
340177001982	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
340177001983	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
340177001984	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
340177001985	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
340177001986	LytB protein; Region: LYTB; cl00507
340177001987	putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814
340177001988	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
340177001989	catalytic loop [active]
340177001990	iron binding site [ion binding]; other site
340177001991	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
340177001992	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
340177001993	Putative addiction module component; Region: Unstab_antitox; pfam09720
340177001994	Predicted transcriptional regulator [Transcription]; Region: COG3905
340177001995	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
340177001996	Nitroreductase family; Region: Nitroreductase; pfam00881
340177001997	FMN binding site [chemical binding]; other site
340177001998	dimer interface [polypeptide binding]; other site
340177001999	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
340177002000	Predicted ATPase [General function prediction only]; Region: COG4637
340177002001	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177002002	Walker A/P-loop; other site
340177002003	ATP binding site [chemical binding]; other site
340177002004	GMP synthase; Reviewed; Region: guaA; PRK00074
340177002005	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
340177002006	AMP/PPi binding site [chemical binding]; other site
340177002007	candidate oxyanion hole; other site
340177002008	catalytic triad [active]
340177002009	potential glutamine specificity residues [chemical binding]; other site
340177002010	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
340177002011	ATP Binding subdomain [chemical binding]; other site
340177002012	Ligand Binding sites [chemical binding]; other site
340177002013	Dimerization subdomain; other site
340177002014	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
340177002015	Transglycosylase; Region: Transgly; pfam00912
340177002016	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
340177002017	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
340177002018	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
340177002019	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
340177002020	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
340177002021	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
340177002022	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
340177002023	active site
340177002024	NTP binding site [chemical binding]; other site
340177002025	metal binding triad [ion binding]; metal-binding site
340177002026	antibiotic binding site [chemical binding]; other site
340177002027	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
340177002028	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551
340177002029	putative acyl-acceptor binding pocket; other site
340177002030	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
340177002031	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340177002032	Coenzyme A binding pocket [chemical binding]; other site
340177002033	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
340177002034	Transposase; Region: DDE_Tnp_ISL3; pfam01610
340177002035	Virulence protein [General function prediction only]; Region: COG3943
340177002036	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
340177002037	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
340177002038	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
340177002039	AMP binding site [chemical binding]; other site
340177002040	metal binding site [ion binding]; metal-binding site
340177002041	active site
340177002042	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
340177002043	DHH family; Region: DHH; pfam01368
340177002044	DHHA1 domain; Region: DHHA1; pfam02272
340177002045	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
340177002046	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
340177002047	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
340177002048	Ligand binding site; other site
340177002049	Putative Catalytic site; other site
340177002050	DXD motif; other site
340177002051	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
340177002052	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
340177002053	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
340177002054	active site
340177002055	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
340177002056	Domain of unknown function (DUF202); Region: DUF202; pfam02656
340177002057	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
340177002058	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
340177002059	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
340177002060	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
340177002061	ATP binding site [chemical binding]; other site
340177002062	Mg2+ binding site [ion binding]; other site
340177002063	G-X-G motif; other site
340177002064	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
340177002065	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
340177002066	active site
340177002067	dimer interface [polypeptide binding]; other site
340177002068	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
340177002069	dimer interface [polypeptide binding]; other site
340177002070	active site
340177002071	SapC; Region: SapC; pfam07277
340177002072	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
340177002073	Outer membrane efflux protein; Region: OEP; pfam02321
340177002074	Outer membrane efflux protein; Region: OEP; pfam02321
340177002075	Beta/Gamma crystallin; Region: Crystall; cl02528
340177002076	hypothetical protein; Provisional; Region: PHA03020
340177002077	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
340177002078	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
340177002079	4Fe-4S binding domain; Region: Fer4; cl02805
340177002080	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
340177002081	thiosulfate reductase PhsA; Provisional; Region: PRK15488
340177002082	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
340177002083	putative [Fe4-S4] binding site [ion binding]; other site
340177002084	putative molybdopterin cofactor binding site [chemical binding]; other site
340177002085	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
340177002086	putative molybdopterin cofactor binding site; other site
340177002087	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
340177002088	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
340177002089	catalytic motif [active]
340177002090	Zn binding site [ion binding]; other site
340177002091	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
340177002092	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
340177002093	catalytic motif [active]
340177002094	Zn binding site [ion binding]; other site
340177002095	RibD C-terminal domain; Region: RibD_C; cl17279
340177002096	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
340177002097	dimer interface [polypeptide binding]; other site
340177002098	catalytic triad [active]
340177002099	peroxidatic and resolving cysteines [active]
340177002100	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
340177002101	Lumazine binding domain; Region: Lum_binding; pfam00677
340177002102	Lumazine binding domain; Region: Lum_binding; pfam00677
340177002103	recombination factor protein RarA; Reviewed; Region: PRK13342
340177002104	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177002105	Walker A motif; other site
340177002106	ATP binding site [chemical binding]; other site
340177002107	Walker B motif; other site
340177002108	arginine finger; other site
340177002109	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
340177002110	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
340177002111	Methyltransferase domain; Region: Methyltransf_23; pfam13489
340177002112	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340177002113	S-adenosylmethionine binding site [chemical binding]; other site
340177002114	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
340177002115	nucleotide binding site/active site [active]
340177002116	HIT family signature motif; other site
340177002117	catalytic residue [active]
340177002118	Ferrochelatase; Region: Ferrochelatase; pfam00762
340177002119	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
340177002120	C-terminal domain interface [polypeptide binding]; other site
340177002121	active site
340177002122	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
340177002123	N-terminal domain interface [polypeptide binding]; other site
340177002124	active site
340177002125	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177002126	binding surface
340177002127	TPR motif; other site
340177002128	TPR repeat; Region: TPR_11; pfam13414
340177002129	TPR repeat; Region: TPR_11; pfam13414
340177002130	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177002131	binding surface
340177002132	TPR motif; other site
340177002133	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
340177002134	NADH dehydrogenase subunit B; Provisional; Region: PRK14813
340177002135	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
340177002136	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
340177002137	NADH dehydrogenase subunit D; Validated; Region: PRK06075
340177002138	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
340177002139	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
340177002140	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
340177002141	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
340177002142	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
340177002143	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
340177002144	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
340177002145	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
340177002146	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
340177002147	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
340177002148	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
340177002149	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
340177002150	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
340177002151	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
340177002152	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
340177002153	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
340177002154	Mg++ binding site [ion binding]; other site
340177002155	putative catalytic motif [active]
340177002156	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
340177002157	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
340177002158	Chain length determinant protein; Region: Wzz; pfam02706
340177002159	tyrosine kinase; Provisional; Region: PRK11519
340177002160	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
340177002161	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
340177002162	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
340177002163	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
340177002164	NADP binding site [chemical binding]; other site
340177002165	active site
340177002166	putative substrate binding site [chemical binding]; other site
340177002167	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
340177002168	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
340177002169	NADP-binding site; other site
340177002170	homotetramer interface [polypeptide binding]; other site
340177002171	substrate binding site [chemical binding]; other site
340177002172	homodimer interface [polypeptide binding]; other site
340177002173	active site
340177002174	PemK-like protein; Region: PemK; pfam02452
340177002175	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
340177002176	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
340177002177	oligomeric interface; other site
340177002178	putative active site [active]
340177002179	homodimer interface [polypeptide binding]; other site
340177002180	Divergent AAA domain; Region: AAA_4; pfam04326
340177002181	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
340177002182	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
340177002183	Transposase; Region: DDE_Tnp_ISL3; pfam01610
340177002184	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
340177002185	putative active site [active]
340177002186	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
340177002187	PemK-like protein; Region: PemK; pfam02452
340177002188	Divergent AAA domain; Region: AAA_4; pfam04326
340177002189	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
340177002190	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
340177002191	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
340177002192	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
340177002193	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340177002194	S-adenosylmethionine binding site [chemical binding]; other site
340177002195	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
340177002196	Ligand Binding Site [chemical binding]; other site
340177002197	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
340177002198	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
340177002199	putative active site [active]
340177002200	putative metal binding site [ion binding]; other site
340177002201	GNT-I family; Region: GNT-I; pfam03071
340177002202	putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325
340177002203	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
340177002204	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340177002205	NAD(P) binding site [chemical binding]; other site
340177002206	active site
340177002207	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
340177002208	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
340177002209	inhibitor-cofactor binding pocket; inhibition site
340177002210	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177002211	catalytic residue [active]
340177002212	putative glycosyl transferase; Provisional; Region: PRK10063
340177002213	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
340177002214	active site
340177002215	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
340177002216	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
340177002217	active site
340177002218	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
340177002219	PIN domain; Region: PIN_3; cl17397
340177002220	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875
340177002221	putative active site [active]
340177002222	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
340177002223	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
340177002224	Putative addiction module component; Region: Unstab_antitox; pfam09720
340177002225	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
340177002226	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177002227	FeS/SAM binding site; other site
340177002228	PUCC protein; Region: PUCC; pfam03209
340177002229	putative lyase; Provisional; Region: PRK09687
340177002230	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
340177002231	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
340177002232	classical (c) SDRs; Region: SDR_c; cd05233
340177002233	NAD(P) binding site [chemical binding]; other site
340177002234	active site
340177002235	Yqey-like protein; Region: YqeY; pfam09424
340177002236	seryl-tRNA synthetase; Provisional; Region: PRK05431
340177002237	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
340177002238	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
340177002239	dimer interface [polypeptide binding]; other site
340177002240	active site
340177002241	motif 1; other site
340177002242	motif 2; other site
340177002243	motif 3; other site
340177002244	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
340177002245	putative active site [active]
340177002246	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
340177002247	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
340177002248	MutS domain III; Region: MutS_III; pfam05192
340177002249	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
340177002250	Walker A/P-loop; other site
340177002251	ATP binding site [chemical binding]; other site
340177002252	Q-loop/lid; other site
340177002253	ABC transporter signature motif; other site
340177002254	Walker B; other site
340177002255	D-loop; other site
340177002256	H-loop/switch region; other site
340177002257	Smr domain; Region: Smr; pfam01713
340177002258	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
340177002259	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
340177002260	dimer interface [polypeptide binding]; other site
340177002261	decamer (pentamer of dimers) interface [polypeptide binding]; other site
340177002262	catalytic triad [active]
340177002263	peroxidatic and resolving cysteines [active]
340177002264	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
340177002265	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
340177002266	catalytic residues [active]
340177002267	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
340177002268	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
340177002269	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
340177002270	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
340177002271	protein-splicing catalytic site; other site
340177002272	thioester formation/cholesterol transfer; other site
340177002273	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
340177002274	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
340177002275	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
340177002276	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
340177002277	TSCPD domain; Region: TSCPD; pfam12637
340177002278	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
340177002279	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
340177002280	Transposase; Region: DDE_Tnp_ISL3; pfam01610
340177002281	prolyl-tRNA synthetase; Provisional; Region: PRK08661
340177002282	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
340177002283	dimer interface [polypeptide binding]; other site
340177002284	motif 1; other site
340177002285	active site
340177002286	motif 2; other site
340177002287	motif 3; other site
340177002288	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
340177002289	anticodon binding site; other site
340177002290	zinc-binding site [ion binding]; other site
340177002291	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
340177002292	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
340177002293	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
340177002294	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
340177002295	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177002296	FeS/SAM binding site; other site
340177002297	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
340177002298	AAA domain; Region: AAA_33; pfam13671
340177002299	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
340177002300	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
340177002301	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177002302	Walker A/P-loop; other site
340177002303	ATP binding site [chemical binding]; other site
340177002304	Q-loop/lid; other site
340177002305	ABC transporter signature motif; other site
340177002306	Walker B; other site
340177002307	D-loop; other site
340177002308	H-loop/switch region; other site
340177002309	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
340177002310	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177002311	Walker A/P-loop; other site
340177002312	ATP binding site [chemical binding]; other site
340177002313	Q-loop/lid; other site
340177002314	ABC transporter signature motif; other site
340177002315	Walker B; other site
340177002316	D-loop; other site
340177002317	H-loop/switch region; other site
340177002318	ParA-like protein; Provisional; Region: PHA02518
340177002319	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
340177002320	P-loop; other site
340177002321	Magnesium ion binding site [ion binding]; other site
340177002322	Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582
340177002323	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
340177002324	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
340177002325	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
340177002326	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
340177002327	active site
340177002328	NTP binding site [chemical binding]; other site
340177002329	metal binding triad [ion binding]; metal-binding site
340177002330	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
340177002331	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
340177002332	Zn2+ binding site [ion binding]; other site
340177002333	Mg2+ binding site [ion binding]; other site
340177002334	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
340177002335	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
340177002336	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
340177002337	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
340177002338	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
340177002339	Major Facilitator Superfamily; Region: MFS_1; pfam07690
340177002340	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340177002341	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340177002342	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
340177002343	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
340177002344	cobalamin binding residues [chemical binding]; other site
340177002345	putative BtuC binding residues; other site
340177002346	dimer interface [polypeptide binding]; other site
340177002347	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
340177002348	nudix motif; other site
340177002349	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
340177002350	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
340177002351	intersubunit interface [polypeptide binding]; other site
340177002352	active site
340177002353	zinc binding site [ion binding]; other site
340177002354	Na+ binding site [ion binding]; other site
340177002355	carboxy-terminal protease; Provisional; Region: PRK11186
340177002356	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
340177002357	protein binding site [polypeptide binding]; other site
340177002358	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
340177002359	Catalytic dyad [active]
340177002360	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
340177002361	argininosuccinate lyase; Provisional; Region: PRK00855
340177002362	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
340177002363	active sites [active]
340177002364	tetramer interface [polypeptide binding]; other site
340177002365	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
340177002366	AAA domain; Region: AAA_33; pfam13671
340177002367	ligand-binding site [chemical binding]; other site
340177002368	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177002369	binding surface
340177002370	TPR motif; other site
340177002371	TPR repeat; Region: TPR_11; pfam13414
340177002372	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177002373	binding surface
340177002374	TPR motif; other site
340177002375	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
340177002376	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177002377	binding surface
340177002378	TPR motif; other site
340177002379	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
340177002380	TIGR03032 family protein; Region: TIGR03032
340177002381	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340177002382	Coenzyme A binding pocket [chemical binding]; other site
340177002383	Influenza RNA-dependent RNA polymerase subunit PA; Region: Flu_PA; pfam00603
340177002384	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
340177002385	active site
340177002386	NTP binding site [chemical binding]; other site
340177002387	metal binding triad [ion binding]; metal-binding site
340177002388	antibiotic binding site [chemical binding]; other site
340177002389	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
340177002390	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177002391	Family description; Region: VCBS; pfam13517
340177002392	Family description; Region: VCBS; pfam13517
340177002393	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177002394	Family description; Region: VCBS; pfam13517
340177002395	Family description; Region: VCBS; pfam13517
340177002396	Family description; Region: VCBS; pfam13517
340177002397	Family description; Region: VCBS; pfam13517
340177002398	Family description; Region: VCBS; pfam13517
340177002399	Family description; Region: VCBS; pfam13517
340177002400	Family description; Region: VCBS; pfam13517
340177002401	Family description; Region: VCBS; pfam13517
340177002402	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177002403	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177002404	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177002405	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177002406	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177002407	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177002408	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177002409	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177002410	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177002411	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177002412	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177002413	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177002414	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177002415	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177002416	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177002417	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177002418	Calx-beta domain; Region: Calx-beta; pfam03160
340177002419	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177002420	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
340177002421	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
340177002422	Walker A/P-loop; other site
340177002423	ATP binding site [chemical binding]; other site
340177002424	Q-loop/lid; other site
340177002425	ABC transporter signature motif; other site
340177002426	Walker B; other site
340177002427	D-loop; other site
340177002428	H-loop/switch region; other site
340177002429	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
340177002430	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
340177002431	Modifier of rudimentary (Mod(r)) protein; Region: Mod_r; pfam07200
340177002432	HlyD family secretion protein; Region: HlyD_3; pfam13437
340177002433	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
340177002434	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
340177002435	Methyltransferase domain; Region: Methyltransf_23; pfam13489
340177002436	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340177002437	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
340177002438	Transposase; Region: DDE_Tnp_ISL3; pfam01610
340177002439	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340177002440	Methyltransferase domain; Region: Methyltransf_23; pfam13489
340177002441	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340177002442	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
340177002443	ribonuclease R; Region: RNase_R; TIGR02063
340177002444	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
340177002445	RNB domain; Region: RNB; pfam00773
340177002446	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
340177002447	RNA binding site [nucleotide binding]; other site
340177002448	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
340177002449	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
340177002450	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
340177002451	ABC-ATPase subunit  interface; other site
340177002452	dimer interface [polypeptide binding]; other site
340177002453	putative PBP binding regions; other site
340177002454	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
340177002455	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
340177002456	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
340177002457	PUA domain; Region: PUA; cl00607
340177002458	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
340177002459	putative RNA binding site [nucleotide binding]; other site
340177002460	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
340177002461	Methyltransferase domain; Region: Methyltransf_26; pfam13659
340177002462	DEAD-like helicases superfamily; Region: DEXDc; smart00487
340177002463	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340177002464	ATP binding site [chemical binding]; other site
340177002465	putative Mg++ binding site [ion binding]; other site
340177002466	T5orf172 domain; Region: T5orf172; pfam10544
340177002467	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
340177002468	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
340177002469	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
340177002470	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
340177002471	Transposase; Region: DDE_Tnp_ISL3; pfam01610
340177002472	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
340177002473	AIPR protein; Region: AIPR; pfam10592
340177002474	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
340177002475	Part of AAA domain; Region: AAA_19; pfam13245
340177002476	Family description; Region: UvrD_C_2; pfam13538
340177002477	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
340177002478	AAA domain; Region: AAA_30; pfam13604
340177002479	Family description; Region: UvrD_C_2; pfam13538
340177002480	YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779
340177002481	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
340177002482	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
340177002483	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
340177002484	heterotetramer interface [polypeptide binding]; other site
340177002485	active site pocket [active]
340177002486	cleavage site
340177002487	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
340177002488	feedback inhibition sensing region; other site
340177002489	homohexameric interface [polypeptide binding]; other site
340177002490	nucleotide binding site [chemical binding]; other site
340177002491	N-acetyl-L-glutamate binding site [chemical binding]; other site
340177002492	ornithine carbamoyltransferase; Provisional; Region: PRK00779
340177002493	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
340177002494	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
340177002495	Arginine repressor [Transcription]; Region: ArgR; COG1438
340177002496	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
340177002497	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
340177002498	argininosuccinate synthase; Provisional; Region: PRK13820
340177002499	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
340177002500	ANP binding site [chemical binding]; other site
340177002501	Substrate Binding Site II [chemical binding]; other site
340177002502	Substrate Binding Site I [chemical binding]; other site
340177002503	DNA repair protein RadA; Provisional; Region: PRK11823
340177002504	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
340177002505	Walker A motif/ATP binding site; other site
340177002506	ATP binding site [chemical binding]; other site
340177002507	Walker B motif; other site
340177002508	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
340177002509	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14174
340177002510	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
340177002511	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
340177002512	homodimer interface [polypeptide binding]; other site
340177002513	NADP binding site [chemical binding]; other site
340177002514	substrate binding site [chemical binding]; other site
340177002515	Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
340177002516	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
340177002517	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
340177002518	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
340177002519	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
340177002520	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
340177002521	active site
340177002522	HslU subunit interaction site [polypeptide binding]; other site
340177002523	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
340177002524	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
340177002525	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177002526	Walker A motif; other site
340177002527	ATP binding site [chemical binding]; other site
340177002528	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177002529	Walker B motif; other site
340177002530	arginine finger; other site
340177002531	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
340177002532	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
340177002533	Dehydroquinase class II; Region: DHquinase_II; pfam01220
340177002534	trimer interface [polypeptide binding]; other site
340177002535	active site
340177002536	dimer interface [polypeptide binding]; other site
340177002537	Predicted membrane protein (DUF2335); Region: DUF2335; pfam10097
340177002538	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
340177002539	active site
340177002540	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
340177002541	Transposase; Region: DDE_Tnp_ISL3; pfam01610
340177002542	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
340177002543	PAS domain; Region: PAS_9; pfam13426
340177002544	putative active site [active]
340177002545	heme pocket [chemical binding]; other site
340177002546	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
340177002547	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340177002548	ATP binding site [chemical binding]; other site
340177002549	Mg2+ binding site [ion binding]; other site
340177002550	G-X-G motif; other site
340177002551	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
340177002552	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
340177002553	phosphorylation site [posttranslational modification]
340177002554	intermolecular recognition site; other site
340177002555	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
340177002556	NlpC/P60 family; Region: NLPC_P60; pfam00877
340177002557	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
340177002558	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
340177002559	ligand binding site [chemical binding]; other site
340177002560	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
340177002561	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
340177002562	putative NADP binding site [chemical binding]; other site
340177002563	putative substrate binding site [chemical binding]; other site
340177002564	active site
340177002565	Predicted membrane protein [Function unknown]; Region: COG2119
340177002566	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
340177002567	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
340177002568	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
340177002569	Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
340177002570	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
340177002571	CoA binding domain; Region: CoA_binding; smart00881
340177002572	ATP citrate (pro-S)-lyase; Region: PLN02522
340177002573	CoA-ligase; Region: Ligase_CoA; pfam00549
340177002574	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
340177002575	active site
340177002576	oxalacetate binding site [chemical binding]; other site
340177002577	citrylCoA binding site [chemical binding]; other site
340177002578	coenzyme A binding site [chemical binding]; other site
340177002579	catalytic triad [active]
340177002580	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
340177002581	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
340177002582	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177002583	homodimer interface [polypeptide binding]; other site
340177002584	catalytic residue [active]
340177002585	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
340177002586	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
340177002587	FAD binding domain; Region: FAD_binding_4; pfam01565
340177002588	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
340177002589	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
340177002590	Cysteine-rich domain; Region: CCG; pfam02754
340177002591	Cysteine-rich domain; Region: CCG; pfam02754
340177002592	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
340177002593	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
340177002594	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
340177002595	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
340177002596	RimM N-terminal domain; Region: RimM; pfam01782
340177002597	PRC-barrel domain; Region: PRC; pfam05239
340177002598	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
340177002599	signal recognition particle protein; Provisional; Region: PRK10867
340177002600	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
340177002601	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
340177002602	P loop; other site
340177002603	GTP binding site [chemical binding]; other site
340177002604	Signal peptide binding domain; Region: SRP_SPB; pfam02978
340177002605	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
340177002606	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
340177002607	putative ribose interaction site [chemical binding]; other site
340177002608	putative ADP binding site [chemical binding]; other site
340177002609	HsdM N-terminal domain; Region: HsdM_N; pfam12161
340177002610	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
340177002611	Methyltransferase domain; Region: Methyltransf_26; pfam13659
340177002612	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
340177002613	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
340177002614	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
340177002615	Transposase IS200 like; Region: Y1_Tnp; pfam01797
340177002616	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
340177002617	DEAD-like helicases superfamily; Region: DEXDc; smart00487
340177002618	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340177002619	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
340177002620	putative Mg++ binding site [ion binding]; other site
340177002621	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
340177002622	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
340177002623	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
340177002624	hydrophobic ligand binding site; other site
340177002625	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
340177002626	hydrophobic ligand binding site; other site
340177002627	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
340177002628	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
340177002629	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
340177002630	protein binding site [polypeptide binding]; other site
340177002631	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
340177002632	Catalytic dyad [active]
340177002633	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
340177002634	homotrimer interaction site [polypeptide binding]; other site
340177002635	putative active site [active]
340177002636	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
340177002637	active site
340177002638	thiamine phosphate binding site [chemical binding]; other site
340177002639	pyrophosphate binding site [ion binding]; other site
340177002640	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
340177002641	thiamine phosphate binding site [chemical binding]; other site
340177002642	active site
340177002643	pyrophosphate binding site [ion binding]; other site
340177002644	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
340177002645	dimer interface [polypeptide binding]; other site
340177002646	substrate binding site [chemical binding]; other site
340177002647	ATP binding site [chemical binding]; other site
340177002648	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
340177002649	putative active site [active]
340177002650	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
340177002651	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
340177002652	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
340177002653	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
340177002654	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
340177002655	Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046
340177002656	multifunctional aminopeptidase A; Provisional; Region: PRK00913
340177002657	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
340177002658	interface (dimer of trimers) [polypeptide binding]; other site
340177002659	Substrate-binding/catalytic site; other site
340177002660	Zn-binding sites [ion binding]; other site
340177002661	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
340177002662	DHH family; Region: DHH; pfam01368
340177002663	DHHA1 domain; Region: DHHA1; pfam02272
340177002664	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14456
340177002665	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177002666	FeS/SAM binding site; other site
340177002667	adenylate kinase; Reviewed; Region: adk; PRK00279
340177002668	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
340177002669	AMP-binding site [chemical binding]; other site
340177002670	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
340177002671	Helix-turn-helix domain; Region: HTH_20; pfam12840
340177002672	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340177002673	primosomal protein N' Region: priA; TIGR00595
340177002674	ATP binding site [chemical binding]; other site
340177002675	putative Mg++ binding site [ion binding]; other site
340177002676	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340177002677	nucleotide binding region [chemical binding]; other site
340177002678	ATP-binding site [chemical binding]; other site
340177002679	PemK-like protein; Region: PemK; pfam02452
340177002680	Protein of unknown function (DUF3018); Region: DUF3018; pfam11455
340177002681	Fic family protein [Function unknown]; Region: COG3177
340177002682	Fic/DOC family; Region: Fic; pfam02661
340177002683	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
340177002684	putative DNA binding site [nucleotide binding]; other site
340177002685	putative Zn2+ binding site [ion binding]; other site
340177002686	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
340177002687	Transposase; Region: DDE_Tnp_ISL3; pfam01610
340177002688	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
340177002689	putative hydrophobic ligand binding site [chemical binding]; other site
340177002690	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
340177002691	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
340177002692	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
340177002693	Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795
340177002694	Predicted amidohydrolase [General function prediction only]; Region: COG0388
340177002695	active site
340177002696	catalytic triad [active]
340177002697	dimer interface [polypeptide binding]; other site
340177002698	AAA ATPase domain; Region: AAA_16; pfam13191
340177002699	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177002700	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177002701	binding surface
340177002702	TPR motif; other site
340177002703	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177002704	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177002705	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177002706	binding surface
340177002707	TPR motif; other site
340177002708	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
340177002709	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177002710	binding surface
340177002711	TPR motif; other site
340177002712	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177002713	binding surface
340177002714	TPR motif; other site
340177002715	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
340177002716	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
340177002717	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
340177002718	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
340177002719	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924
340177002720	Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795
340177002721	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
340177002722	toxin interface [polypeptide binding]; other site
340177002723	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
340177002724	YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831
340177002725	Zn binding site [ion binding]; other site
340177002726	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340177002727	non-specific DNA binding site [nucleotide binding]; other site
340177002728	salt bridge; other site
340177002729	sequence-specific DNA binding site [nucleotide binding]; other site
340177002730	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
340177002731	homotrimer interface [polypeptide binding]; other site
340177002732	Walker A motif; other site
340177002733	GTP binding site [chemical binding]; other site
340177002734	Walker B motif; other site
340177002735	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
340177002736	AAA domain; Region: AAA_30; pfam13604
340177002737	Family description; Region: UvrD_C_2; pfam13538
340177002738	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
340177002739	IHF dimer interface [polypeptide binding]; other site
340177002740	IHF - DNA interface [nucleotide binding]; other site
340177002741	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
340177002742	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
340177002743	Walker A/P-loop; other site
340177002744	ATP binding site [chemical binding]; other site
340177002745	Q-loop/lid; other site
340177002746	ABC transporter signature motif; other site
340177002747	Walker B; other site
340177002748	D-loop; other site
340177002749	H-loop/switch region; other site
340177002750	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
340177002751	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
340177002752	Walker A/P-loop; other site
340177002753	ATP binding site [chemical binding]; other site
340177002754	Q-loop/lid; other site
340177002755	ABC transporter signature motif; other site
340177002756	Walker B; other site
340177002757	D-loop; other site
340177002758	H-loop/switch region; other site
340177002759	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
340177002760	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
340177002761	TM-ABC transporter signature motif; other site
340177002762	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
340177002763	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
340177002764	TM-ABC transporter signature motif; other site
340177002765	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
340177002766	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
340177002767	HTH domain; Region: HTH_11; cl17392
340177002768	NACHT domain; Region: NACHT; pfam05729
340177002769	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
340177002770	Uncharacterized conserved protein [Function unknown]; Region: COG1262
340177002771	Protein of unknown function (DUF2281); Region: DUF2281; pfam10047
340177002772	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
340177002773	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
340177002774	active site
340177002775	catalytic residues [active]
340177002776	metal binding site [ion binding]; metal-binding site
340177002777	homodimer binding site [polypeptide binding]; other site
340177002778	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
340177002779	carboxyltransferase (CT) interaction site; other site
340177002780	biotinylation site [posttranslational modification]; other site
340177002781	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
340177002782	Fumarase C-terminus; Region: Fumerase_C; pfam05683
340177002783	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
340177002784	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
340177002785	AAA domain; Region: AAA_33; pfam13671
340177002786	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
340177002787	ATP-binding site [chemical binding]; other site
340177002788	Gluconate-6-phosphate binding site [chemical binding]; other site
340177002789	malate dehydrogenase; Reviewed; Region: PRK06223
340177002790	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
340177002791	NAD(P) binding site [chemical binding]; other site
340177002792	dimer interface [polypeptide binding]; other site
340177002793	tetramer (dimer of dimers) interface [polypeptide binding]; other site
340177002794	substrate binding site [chemical binding]; other site
340177002795	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
340177002796	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
340177002797	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
340177002798	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
340177002799	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
340177002800	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
340177002801	Walker A/P-loop; other site
340177002802	ATP binding site [chemical binding]; other site
340177002803	Q-loop/lid; other site
340177002804	ABC transporter signature motif; other site
340177002805	Walker B; other site
340177002806	D-loop; other site
340177002807	H-loop/switch region; other site
340177002808	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
340177002809	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
340177002810	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
340177002811	HlyD family secretion protein; Region: HlyD_3; pfam13437
340177002812	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177002813	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177002814	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177002815	binding surface
340177002816	TPR motif; other site
340177002817	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177002818	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
340177002819	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
340177002820	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
340177002821	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
340177002822	catalytic triad [active]
340177002823	photolyase PhrII; Region: phr2; TIGR00591
340177002824	DNA photolyase; Region: DNA_photolyase; pfam00875
340177002825	AAA domain; Region: AAA_21; pfam13304
340177002826	6-phosphofructokinase; Provisional; Region: PRK03202
340177002827	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
340177002828	active site
340177002829	ADP/pyrophosphate binding site [chemical binding]; other site
340177002830	dimerization interface [polypeptide binding]; other site
340177002831	allosteric effector site; other site
340177002832	fructose-1,6-bisphosphate binding site; other site
340177002833	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
340177002834	putative active site [active]
340177002835	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
340177002836	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
340177002837	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603
340177002838	Methyltransferase domain; Region: Methyltransf_31; pfam13847
340177002839	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340177002840	S-adenosylmethionine binding site [chemical binding]; other site
340177002841	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
340177002842	OsmC-like protein; Region: OsmC; pfam02566
340177002843	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183
340177002844	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
340177002845	putative active site [active]
340177002846	metal binding site [ion binding]; metal-binding site
340177002847	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340177002848	Major Facilitator Superfamily; Region: MFS_1; pfam07690
340177002849	putative substrate translocation pore; other site
340177002850	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
340177002851	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
340177002852	DNA binding site [nucleotide binding]
340177002853	active site
340177002854	Caspase domain; Region: Peptidase_C14; pfam00656
340177002855	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
340177002856	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
340177002857	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
340177002858	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
340177002859	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
340177002860	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
340177002861	active site
340177002862	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
340177002863	generic binding surface II; other site
340177002864	generic binding surface I; other site
340177002865	Uncharacterized conserved protein [Function unknown]; Region: COG1479
340177002866	Protein of unknown function DUF262; Region: DUF262; pfam03235
340177002867	Protein of unknown function DUF262; Region: DUF262; pfam03235
340177002868	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
340177002869	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
340177002870	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340177002871	Coenzyme A binding pocket [chemical binding]; other site
340177002872	Methyltransferase domain; Region: Methyltransf_23; pfam13489
340177002873	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340177002874	S-adenosylmethionine binding site [chemical binding]; other site
340177002875	dihydroorotase; Validated; Region: pyrC; PRK09357
340177002876	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
340177002877	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
340177002878	active site
340177002879	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
340177002880	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
340177002881	polyphosphate kinase; Provisional; Region: PRK05443
340177002882	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
340177002883	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
340177002884	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
340177002885	putative domain interface [polypeptide binding]; other site
340177002886	putative active site [active]
340177002887	catalytic site [active]
340177002888	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
340177002889	putative domain interface [polypeptide binding]; other site
340177002890	putative active site [active]
340177002891	catalytic site [active]
340177002892	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
340177002893	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
340177002894	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
340177002895	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
340177002896	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
340177002897	metal binding site [ion binding]; metal-binding site
340177002898	dimer interface [polypeptide binding]; other site
340177002899	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
340177002900	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
340177002901	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
340177002902	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
340177002903	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
340177002904	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
340177002905	oligomerization interface [polypeptide binding]; other site
340177002906	active site
340177002907	metal binding site [ion binding]; metal-binding site
340177002908	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
340177002909	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
340177002910	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
340177002911	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
340177002912	putative active site [active]
340177002913	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
340177002914	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
340177002915	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340177002916	non-specific DNA binding site [nucleotide binding]; other site
340177002917	salt bridge; other site
340177002918	sequence-specific DNA binding site [nucleotide binding]; other site
340177002919	Cytochrome c; Region: Cytochrom_C; pfam00034
340177002920	Cytochrome c; Region: Cytochrom_C; cl11414
340177002921	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
340177002922	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
340177002923	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
340177002924	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
340177002925	FtsX-like permease family; Region: FtsX; pfam02687
340177002926	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
340177002927	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
340177002928	metal binding site [ion binding]; metal-binding site
340177002929	active site
340177002930	I-site; other site
340177002931	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
340177002932	amino acid transporter; Region: 2A0306; TIGR00909
340177002933	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
340177002934	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
340177002935	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
340177002936	NAD(P) binding site [chemical binding]; other site
340177002937	active site
340177002938	thymidylate kinase; Validated; Region: tmk; PRK00698
340177002939	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
340177002940	TMP-binding site; other site
340177002941	ATP-binding site [chemical binding]; other site
340177002942	phosphoglycolate phosphatase; Provisional; Region: PRK01158
340177002943	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
340177002944	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340177002945	motif II; other site
340177002946	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
340177002947	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
340177002948	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
340177002949	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
340177002950	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
340177002951	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
340177002952	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
340177002953	substrate binding site; other site
340177002954	dimer interface; other site
340177002955	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
340177002956	CoenzymeA binding site [chemical binding]; other site
340177002957	subunit interaction site [polypeptide binding]; other site
340177002958	PHB binding site; other site
340177002959	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
340177002960	B12 binding site [chemical binding]; other site
340177002961	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
340177002962	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177002963	FeS/SAM binding site; other site
340177002964	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
340177002965	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
340177002966	dimer interface [polypeptide binding]; other site
340177002967	anticodon binding site; other site
340177002968	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
340177002969	homodimer interface [polypeptide binding]; other site
340177002970	motif 1; other site
340177002971	active site
340177002972	motif 2; other site
340177002973	GAD domain; Region: GAD; pfam02938
340177002974	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
340177002975	active site
340177002976	motif 3; other site
340177002977	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954
340177002978	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14955
340177002979	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177002980	Walker A motif; other site
340177002981	ATP binding site [chemical binding]; other site
340177002982	Walker B motif; other site
340177002983	arginine finger; other site
340177002984	ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214
340177002985	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
340177002986	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340177002987	putative substrate translocation pore; other site
340177002988	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
340177002989	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
340177002990	putative active site [active]
340177002991	catalytic triad [active]
340177002992	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
340177002993	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
340177002994	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
340177002995	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
340177002996	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
340177002997	Peptidase family M48; Region: Peptidase_M48; pfam01435
340177002998	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
340177002999	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
340177003000	putative active site; other site
340177003001	catalytic triad [active]
340177003002	putative dimer interface [polypeptide binding]; other site
340177003003	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
340177003004	UbiA prenyltransferase family; Region: UbiA; pfam01040
340177003005	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
340177003006	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
340177003007	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
340177003008	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
340177003009	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
340177003010	G1 box; other site
340177003011	putative GEF interaction site [polypeptide binding]; other site
340177003012	GTP/Mg2+ binding site [chemical binding]; other site
340177003013	Switch I region; other site
340177003014	G2 box; other site
340177003015	G3 box; other site
340177003016	Switch II region; other site
340177003017	G4 box; other site
340177003018	G5 box; other site
340177003019	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
340177003020	ATP-grasp domain; Region: ATP-grasp_4; cl17255
340177003021	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
340177003022	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340177003023	Coenzyme A binding pocket [chemical binding]; other site
340177003024	cyanophycin synthetase; Provisional; Region: PRK14016
340177003025	ATP-grasp domain; Region: ATP-grasp_4; cl17255
340177003026	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
340177003027	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
340177003028	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
340177003029	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
340177003030	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
340177003031	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
340177003032	DMSO reductase family type II enzyme, molybdopterin subunit; Region: DMSO_red_II_alp; TIGR03479
340177003033	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
340177003034	molybdopterin cofactor binding site; other site
340177003035	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
340177003036	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
340177003037	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
340177003038	putative molybdopterin cofactor binding site; other site
340177003039	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
340177003040	active site residue [active]
340177003041	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
340177003042	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
340177003043	Protein of unknown function (DUF3795); Region: DUF3795; pfam12675
340177003044	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
340177003045	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
340177003046	metal-binding site [ion binding]
340177003047	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
340177003048	Soluble P-type ATPase [General function prediction only]; Region: COG4087
340177003049	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
340177003050	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
340177003051	methionine sulfoxide reductase A; Provisional; Region: PRK14054
340177003052	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
340177003053	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
340177003054	active site
340177003055	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
340177003056	PASTA domain; Region: PASTA; pfam03793
340177003057	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
340177003058	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
340177003059	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
340177003060	substrate binding pocket [chemical binding]; other site
340177003061	chain length determination region; other site
340177003062	substrate-Mg2+ binding site; other site
340177003063	catalytic residues [active]
340177003064	aspartate-rich region 1; other site
340177003065	active site lid residues [active]
340177003066	aspartate-rich region 2; other site
340177003067	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
340177003068	dephospho-CoA kinase; Provisional; Region: coaE; PRK14731
340177003069	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
340177003070	CoA-binding site [chemical binding]; other site
340177003071	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
340177003072	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
340177003073	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
340177003074	Domain of unknown function (DUF3127); Region: DUF3127; pfam11325
340177003075	DoxX-like family; Region: DoxX_3; pfam13781
340177003076	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
340177003077	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
340177003078	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
340177003079	HlyD family secretion protein; Region: HlyD_3; pfam13437
340177003080	PhoU domain; Region: PhoU; pfam01895
340177003081	PhoU domain; Region: PhoU; pfam01895
340177003082	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
340177003083	PhoU domain; Region: PhoU; pfam01895
340177003084	PhoU domain; Region: PhoU; pfam01895
340177003085	putative minor structural protein; Region: PHA01351
340177003086	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
340177003087	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340177003088	motif II; other site
340177003089	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
340177003090	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
340177003091	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
340177003092	P-loop; other site
340177003093	Magnesium ion binding site [ion binding]; other site
340177003094	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
340177003095	Magnesium ion binding site [ion binding]; other site
340177003096	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
340177003097	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
340177003098	Walker A/P-loop; other site
340177003099	ATP binding site [chemical binding]; other site
340177003100	Q-loop/lid; other site
340177003101	ABC transporter signature motif; other site
340177003102	Walker B; other site
340177003103	D-loop; other site
340177003104	H-loop/switch region; other site
340177003105	Fic family protein [Function unknown]; Region: COG3177
340177003106	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
340177003107	Fic/DOC family; Region: Fic; pfam02661
340177003108	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
340177003109	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340177003110	Coenzyme A binding pocket [chemical binding]; other site
340177003111	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
340177003112	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
340177003113	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
340177003114	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
340177003115	acyl-activating enzyme (AAE) consensus motif; other site
340177003116	acyl-activating enzyme (AAE) consensus motif; other site
340177003117	AMP binding site [chemical binding]; other site
340177003118	active site
340177003119	CoA binding site [chemical binding]; other site
340177003120	ATP-grasp domain; Region: ATP-grasp_4; cl17255
340177003121	magnesium chelatase, H subunit; Region: BchH; TIGR02025
340177003122	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
340177003123	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
340177003124	CHAT domain; Region: CHAT; cl17868
340177003125	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
340177003126	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
340177003127	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
340177003128	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
340177003129	HlyD family secretion protein; Region: HlyD_3; pfam13437
340177003130	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
340177003131	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
340177003132	Walker A/P-loop; other site
340177003133	ATP binding site [chemical binding]; other site
340177003134	Q-loop/lid; other site
340177003135	ABC transporter signature motif; other site
340177003136	Walker B; other site
340177003137	D-loop; other site
340177003138	H-loop/switch region; other site
340177003139	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
340177003140	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
340177003141	FtsX-like permease family; Region: FtsX; pfam02687
340177003142	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
340177003143	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
340177003144	FtsX-like permease family; Region: FtsX; pfam02687
340177003145	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
340177003146	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
340177003147	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
340177003148	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
340177003149	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
340177003150	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
340177003151	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
340177003152	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
340177003153	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
340177003154	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
340177003155	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
340177003156	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177003157	homodimer interface [polypeptide binding]; other site
340177003158	catalytic residue [active]
340177003159	cobyric acid synthase; Provisional; Region: PRK00784
340177003160	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
340177003161	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
340177003162	catalytic triad [active]
340177003163	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
340177003164	putative FMN binding site [chemical binding]; other site
340177003165	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
340177003166	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
340177003167	N-terminal plug; other site
340177003168	ligand-binding site [chemical binding]; other site
340177003169	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
340177003170	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
340177003171	NADH(P)-binding; Region: NAD_binding_10; pfam13460
340177003172	NAD(P) binding site [chemical binding]; other site
340177003173	putative active site [active]
340177003174	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
340177003175	8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588
340177003176	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
340177003177	minor groove reading motif; other site
340177003178	helix-hairpin-helix signature motif; other site
340177003179	substrate binding pocket [chemical binding]; other site
340177003180	active site
340177003181	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900
340177003182	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
340177003183	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340177003184	nucleotide binding region [chemical binding]; other site
340177003185	ATP-binding site [chemical binding]; other site
340177003186	SEC-C motif; Region: SEC-C; pfam02810
340177003187	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
340177003188	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
340177003189	dimerization interface [polypeptide binding]; other site
340177003190	ATP binding site [chemical binding]; other site
340177003191	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
340177003192	dimerization interface [polypeptide binding]; other site
340177003193	ATP binding site [chemical binding]; other site
340177003194	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
340177003195	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
340177003196	putative substrate binding site [chemical binding]; other site
340177003197	putative ATP binding site [chemical binding]; other site
340177003198	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
340177003199	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
340177003200	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177003201	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177003202	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177003203	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177003204	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177003205	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177003206	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177003207	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177003208	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177003209	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177003210	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177003211	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177003212	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177003213	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177003214	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
340177003215	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
340177003216	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340177003217	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
340177003218	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
340177003219	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
340177003220	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
340177003221	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
340177003222	ligand binding surface [chemical binding]; other site
340177003223	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
340177003224	ligand binding surface [chemical binding]; other site
340177003225	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
340177003226	ligand binding surface [chemical binding]; other site
340177003227	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
340177003228	ligand binding surface [chemical binding]; other site
340177003229	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
340177003230	ligand binding surface [chemical binding]; other site
340177003231	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
340177003232	ligand binding surface [chemical binding]; other site
340177003233	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
340177003234	ligand binding surface [chemical binding]; other site
340177003235	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
340177003236	ligand binding surface [chemical binding]; other site
340177003237	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177003238	Family description; Region: VCBS; pfam13517
340177003239	Family description; Region: VCBS; pfam13517
340177003240	Family description; Region: VCBS; pfam13517
340177003241	aspartate aminotransferase; Provisional; Region: PRK08636
340177003242	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
340177003243	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177003244	homodimer interface [polypeptide binding]; other site
340177003245	catalytic residue [active]
340177003246	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
340177003247	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
340177003248	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
340177003249	Cysteine-rich domain; Region: CCG; pfam02754
340177003250	Cysteine-rich domain; Region: CCG; pfam02754
340177003251	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
340177003252	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
340177003253	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
340177003254	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
340177003255	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
340177003256	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
340177003257	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
340177003258	FAD binding pocket [chemical binding]; other site
340177003259	FAD binding motif [chemical binding]; other site
340177003260	phosphate binding motif [ion binding]; other site
340177003261	beta-alpha-beta structure motif; other site
340177003262	NAD binding pocket [chemical binding]; other site
340177003263	Iron coordination center [ion binding]; other site
340177003264	YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779
340177003265	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
340177003266	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
340177003267	ligand binding site [chemical binding]; other site
340177003268	YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779
340177003269	STIM1 Orai1-activating region; Region: SOAR; cd11722
340177003270	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
340177003271	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
340177003272	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
340177003273	Dicarboxylate transport; Region: DctA-YdbH; cl14674
340177003274	Dicarboxylate transport; Region: DctA-YdbH; cl14674
340177003275	Dicarboxylate transport; Region: DctA-YdbH; pfam11739
340177003276	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
340177003277	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
340177003278	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
340177003279	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
340177003280	Putative addiction module component; Region: Unstab_antitox; pfam09720
340177003281	Putative addiction module component; Region: Unstab_antitox; pfam09720
340177003282	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
340177003283	flavoprotein, HI0933 family; Region: TIGR00275
340177003284	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
340177003285	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
340177003286	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
340177003287	autotransporter-associated beta strand repeat; Region: autotrns_rpt; TIGR02601
340177003288	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
340177003289	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
340177003290	Surface antigen; Region: Bac_surface_Ag; pfam01103
340177003291	haemagglutination activity domain; Region: Haemagg_act; smart00912
340177003292	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
340177003293	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
340177003294	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
340177003295	Surface antigen; Region: Bac_surface_Ag; pfam01103
340177003296	cobalamin synthase; Reviewed; Region: cobS; PRK00235
340177003297	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
340177003298	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
340177003299	active site pocket [active]
340177003300	putative dimer interface [polypeptide binding]; other site
340177003301	putative cataytic base [active]
340177003302	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
340177003303	NADH(P)-binding; Region: NAD_binding_10; pfam13460
340177003304	NAD(P) binding site [chemical binding]; other site
340177003305	putative active site [active]
340177003306	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional; Region: PRK14490
340177003307	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
340177003308	Walker A motif; other site
340177003309	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
340177003310	GTP binding site; other site
340177003311	Abi-like protein; Region: Abi_2; cl01988
340177003312	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
340177003313	Transposase; Region: DDE_Tnp_ISL3; pfam01610
340177003314	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
340177003315	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
340177003316	dimer interface [polypeptide binding]; other site
340177003317	putative functional site; other site
340177003318	putative MPT binding site; other site
340177003319	bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604
340177003320	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
340177003321	trimer interface [polypeptide binding]; other site
340177003322	dimer interface [polypeptide binding]; other site
340177003323	putative active site [active]
340177003324	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
340177003325	MPT binding site; other site
340177003326	trimer interface [polypeptide binding]; other site
340177003327	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
340177003328	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
340177003329	lipoyl synthase; Provisional; Region: PRK05481
340177003330	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
340177003331	diiron binding motif [ion binding]; other site
340177003332	CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
340177003333	heat shock protein 90; Provisional; Region: PRK05218
340177003334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340177003335	ATP binding site [chemical binding]; other site
340177003336	Mg2+ binding site [ion binding]; other site
340177003337	G-X-G motif; other site
340177003338	NeuB family; Region: NeuB; pfam03102
340177003339	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
340177003340	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
340177003341	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586
340177003342	Predicted amidohydrolase [General function prediction only]; Region: COG0388
340177003343	putative active site [active]
340177003344	catalytic triad [active]
340177003345	putative dimer interface [polypeptide binding]; other site
340177003346	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
340177003347	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
340177003348	putative active site [active]
340177003349	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
340177003350	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
340177003351	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
340177003352	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
340177003353	Walker A/P-loop; other site
340177003354	ATP binding site [chemical binding]; other site
340177003355	Q-loop/lid; other site
340177003356	ABC transporter signature motif; other site
340177003357	Walker B; other site
340177003358	D-loop; other site
340177003359	H-loop/switch region; other site
340177003360	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
340177003361	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
340177003362	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
340177003363	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
340177003364	benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
340177003365	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
340177003366	PhoH-like protein; Region: PhoH; pfam02562
340177003367	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
340177003368	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
340177003369	NADP binding site [chemical binding]; other site
340177003370	homopentamer interface [polypeptide binding]; other site
340177003371	substrate binding site [chemical binding]; other site
340177003372	active site
340177003373	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
340177003374	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
340177003375	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177003376	homodimer interface [polypeptide binding]; other site
340177003377	catalytic residue [active]
340177003378	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
340177003379	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
340177003380	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
340177003381	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
340177003382	putative active site [active]
340177003383	catalytic residue [active]
340177003384	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
340177003385	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
340177003386	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
340177003387	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
340177003388	AAA domain; Region: AAA_27; pfam13514
340177003389	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
340177003390	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
340177003391	active site
340177003392	metal binding site [ion binding]; metal-binding site
340177003393	DNA binding site [nucleotide binding]
340177003394	RmuC family; Region: RmuC; pfam02646
340177003395	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
340177003396	gamma-glutamyl kinase; Provisional; Region: PRK05429
340177003397	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
340177003398	nucleotide binding site [chemical binding]; other site
340177003399	homotetrameric interface [polypeptide binding]; other site
340177003400	putative phosphate binding site [ion binding]; other site
340177003401	putative allosteric binding site; other site
340177003402	PUA domain; Region: PUA; pfam01472
340177003403	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340177003404	dimerization interface [polypeptide binding]; other site
340177003405	putative Zn2+ binding site [ion binding]; other site
340177003406	putative DNA binding site [nucleotide binding]; other site
340177003407	Fic family protein [Function unknown]; Region: COG3177
340177003408	Fic/DOC family; Region: Fic; pfam02661
340177003409	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
340177003410	DNA methylase; Region: N6_N4_Mtase; pfam01555
340177003411	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
340177003412	Catalytic site; other site
340177003413	MjaI restriction endonuclease; Region: RE_MjaI; pfam09568
340177003414	Divergent AAA domain; Region: AAA_4; pfam04326
340177003415	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
340177003416	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
340177003417	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
340177003418	putative catalytic cysteine [active]
340177003419	Protein of unknown function (DUF497); Region: DUF497; pfam04365
340177003420	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
340177003421	UbiA prenyltransferase family; Region: UbiA; pfam01040
340177003422	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
340177003423	active site
340177003424	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
340177003425	Competence protein; Region: Competence; pfam03772
340177003426	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
340177003427	FAD binding site [chemical binding]; other site
340177003428	diaminopimelate decarboxylase; Region: lysA; TIGR01048
340177003429	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
340177003430	active site
340177003431	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
340177003432	substrate binding site [chemical binding]; other site
340177003433	catalytic residues [active]
340177003434	dimer interface [polypeptide binding]; other site
340177003435	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
340177003436	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
340177003437	Putative zinc ribbon domain; Region: DUF164; pfam02591
340177003438	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
340177003439	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
340177003440	inhibitor-cofactor binding pocket; inhibition site
340177003441	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177003442	catalytic residue [active]
340177003443	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
340177003444	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
340177003445	helicase 45; Provisional; Region: PTZ00424
340177003446	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
340177003447	ATP binding site [chemical binding]; other site
340177003448	Mg++ binding site [ion binding]; other site
340177003449	motif III; other site
340177003450	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340177003451	nucleotide binding region [chemical binding]; other site
340177003452	ATP-binding site [chemical binding]; other site
340177003453	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
340177003454	putative RNA binding site [nucleotide binding]; other site
340177003455	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
340177003456	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
340177003457	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
340177003458	active site
340177003459	Int/Topo IB signature motif; other site
340177003460	16S rRNA methyltransferase B; Provisional; Region: PRK14904
340177003461	NusB family; Region: NusB; pfam01029
340177003462	putative RNA binding site [nucleotide binding]; other site
340177003463	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340177003464	S-adenosylmethionine binding site [chemical binding]; other site
340177003465	HsdM N-terminal domain; Region: HsdM_N; pfam12161
340177003466	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
340177003467	Methyltransferase domain; Region: Methyltransf_26; pfam13659
340177003468	BRO family, N-terminal domain; Region: Bro-N; pfam02498
340177003469	ORF6N domain; Region: ORF6N; pfam10543
340177003470	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
340177003471	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
340177003472	Transposase IS200 like; Region: Y1_Tnp; cl00848
340177003473	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
340177003474	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
340177003475	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340177003476	ATP binding site [chemical binding]; other site
340177003477	putative Mg++ binding site [ion binding]; other site
340177003478	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
340177003479	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
340177003480	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
340177003481	acyl-activating enzyme (AAE) consensus motif; other site
340177003482	putative AMP binding site [chemical binding]; other site
340177003483	putative active site [active]
340177003484	putative CoA binding site [chemical binding]; other site
340177003485	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
340177003486	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
340177003487	dimer interface [polypeptide binding]; other site
340177003488	metal binding site [ion binding]; metal-binding site
340177003489	substrate binding site [chemical binding]; other site
340177003490	acetyl-coenzyme A carboxylase carboxyl transferase; Provisional; Region: PLN03230
340177003491	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
340177003492	substrate binding site [chemical binding]; other site
340177003493	oxyanion hole (OAH) forming residues; other site
340177003494	trimer interface [polypeptide binding]; other site
340177003495	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
340177003496	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
340177003497	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
340177003498	active site
340177003499	NAD binding site [chemical binding]; other site
340177003500	metal binding site [ion binding]; metal-binding site
340177003501	Putative addiction module component; Region: Unstab_antitox; pfam09720
340177003502	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
340177003503	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
340177003504	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
340177003505	ligand binding site; other site
340177003506	tetramer interface; other site
340177003507	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
340177003508	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
340177003509	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
340177003510	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
340177003511	acyl-activating enzyme (AAE) consensus motif; other site
340177003512	putative AMP binding site [chemical binding]; other site
340177003513	putative active site [active]
340177003514	putative CoA binding site [chemical binding]; other site
340177003515	Transposase IS200 like; Region: Y1_Tnp; cl00848
340177003516	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
340177003517	endonuclease III; Region: ENDO3c; smart00478
340177003518	minor groove reading motif; other site
340177003519	helix-hairpin-helix signature motif; other site
340177003520	substrate binding pocket [chemical binding]; other site
340177003521	active site
340177003522	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
340177003523	adenylosuccinate lyase; Provisional; Region: PRK07492
340177003524	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
340177003525	tetramer interface [polypeptide binding]; other site
340177003526	active site
340177003527	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
340177003528	DoxX; Region: DoxX; pfam07681
340177003529	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
340177003530	TPR motif; other site
340177003531	binding surface
340177003532	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177003533	TPR motif; other site
340177003534	binding surface
340177003535	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
340177003536	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
340177003537	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
340177003538	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
340177003539	Soluble P-type ATPase [General function prediction only]; Region: COG4087
340177003540	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
340177003541	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
340177003542	Cation efflux family; Region: Cation_efflux; pfam01545
340177003543	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
340177003544	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
340177003545	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
340177003546	heme-binding residues [chemical binding]; other site
340177003547	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
340177003548	nudix motif; other site
340177003549	DsrE/DsrF-like family; Region: DrsE; pfam02635
340177003550	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
340177003551	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
340177003552	catalytic residues [active]
340177003553	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
340177003554	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
340177003555	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
340177003556	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
340177003557	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
340177003558	ligand binding site [chemical binding]; other site
340177003559	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
340177003560	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
340177003561	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
340177003562	putative CoA binding site [chemical binding]; other site
340177003563	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
340177003564	trimer interface [polypeptide binding]; other site
340177003565	active site
340177003566	UDP-GlcNAc binding site [chemical binding]; other site
340177003567	lipid binding site [chemical binding]; lipid-binding site
340177003568	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
340177003569	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
340177003570	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
340177003571	active site
340177003572	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
340177003573	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
340177003574	5S rRNA interface [nucleotide binding]; other site
340177003575	CTC domain interface [polypeptide binding]; other site
340177003576	L16 interface [polypeptide binding]; other site
340177003577	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
340177003578	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
340177003579	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340177003580	dimer interface [polypeptide binding]; other site
340177003581	conserved gate region; other site
340177003582	putative PBP binding loops; other site
340177003583	ABC-ATPase subunit interface; other site
340177003584	L-aspartate oxidase; Provisional; Region: PRK09077
340177003585	L-aspartate oxidase; Provisional; Region: PRK06175
340177003586	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
340177003587	pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285
340177003588	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
340177003589	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
340177003590	active site
340177003591	HIGH motif; other site
340177003592	dimer interface [polypeptide binding]; other site
340177003593	KMSKS motif; other site
340177003594	S4 RNA-binding domain; Region: S4; smart00363
340177003595	RNA binding surface [nucleotide binding]; other site
340177003596	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
340177003597	SmpB-tmRNA interface; other site
340177003598	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
340177003599	FAD binding domain; Region: FAD_binding_4; pfam01565
340177003600	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
340177003601	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
340177003602	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
340177003603	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
340177003604	rod shape-determining protein MreC; Provisional; Region: PRK13922
340177003605	rod shape-determining protein MreC; Region: MreC; pfam04085
340177003606	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
340177003607	oligomerisation interface [polypeptide binding]; other site
340177003608	mobile loop; other site
340177003609	roof hairpin; other site
340177003610	Quinolinate synthetase A protein; Region: NadA; pfam02445
340177003611	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177003612	binding surface
340177003613	TPR motif; other site
340177003614	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177003615	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177003616	binding surface
340177003617	TPR motif; other site
340177003618	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177003619	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177003620	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177003621	binding surface
340177003622	TPR motif; other site
340177003623	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177003624	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
340177003625	putative active site [active]
340177003626	putative metal binding site [ion binding]; other site
340177003627	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
340177003628	active site clefts [active]
340177003629	zinc binding site [ion binding]; other site
340177003630	dimer interface [polypeptide binding]; other site
340177003631	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
340177003632	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
340177003633	catalytic loop [active]
340177003634	iron binding site [ion binding]; other site
340177003635	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
340177003636	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
340177003637	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
340177003638	HflX GTPase family; Region: HflX; cd01878
340177003639	G1 box; other site
340177003640	GTP/Mg2+ binding site [chemical binding]; other site
340177003641	Switch I region; other site
340177003642	G2 box; other site
340177003643	G3 box; other site
340177003644	Switch II region; other site
340177003645	G4 box; other site
340177003646	G5 box; other site
340177003647	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
340177003648	active site lid residues [active]
340177003649	substrate binding pocket [chemical binding]; other site
340177003650	catalytic residues [active]
340177003651	substrate-Mg2+ binding site; other site
340177003652	aspartate-rich region 1; other site
340177003653	aspartate-rich region 2; other site
340177003654	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
340177003655	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
340177003656	dimer interface [polypeptide binding]; other site
340177003657	putative anticodon binding site; other site
340177003658	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
340177003659	motif 1; other site
340177003660	active site
340177003661	motif 2; other site
340177003662	motif 3; other site
340177003663	PIN domain; Region: PIN; pfam01850
340177003664	SWIM zinc finger; Region: SWIM; pfam04434
340177003665	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
340177003666	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
340177003667	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
340177003668	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
340177003669	putative NAD(P) binding site [chemical binding]; other site
340177003670	active site
340177003671	putative substrate binding site [chemical binding]; other site
340177003672	Uncharacterized conserved protein [Function unknown]; Region: COG2308
340177003673	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
340177003674	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
340177003675	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
340177003676	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
340177003677	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
340177003678	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
340177003679	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
340177003680	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
340177003681	phytoene desaturase; Region: phytoene_desat; TIGR02731
340177003682	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
340177003683	recombination protein RecR; Reviewed; Region: recR; PRK00076
340177003684	RecR protein; Region: RecR; pfam02132
340177003685	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
340177003686	putative active site [active]
340177003687	putative metal-binding site [ion binding]; other site
340177003688	tetramer interface [polypeptide binding]; other site
340177003689	hypothetical protein; Provisional; Region: PRK14621
340177003690	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
340177003691	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
340177003692	PYR/PP interface [polypeptide binding]; other site
340177003693	dimer interface [polypeptide binding]; other site
340177003694	TPP binding site [chemical binding]; other site
340177003695	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
340177003696	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
340177003697	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
340177003698	S-adenosylmethionine binding site [chemical binding]; other site
340177003699	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
340177003700	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340177003701	non-specific DNA binding site [nucleotide binding]; other site
340177003702	salt bridge; other site
340177003703	sequence-specific DNA binding site [nucleotide binding]; other site
340177003704	Domain of unknown function (DUF955); Region: DUF955; pfam06114
340177003705	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
340177003706	Predicted helicase [General function prediction only]; Region: COG4889
340177003707	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
340177003708	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
340177003709	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
340177003710	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
340177003711	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
340177003712	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
340177003713	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
340177003714	E3 interaction surface; other site
340177003715	lipoyl attachment site [posttranslational modification]; other site
340177003716	HlyD family secretion protein; Region: HlyD_3; pfam13437
340177003717	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
340177003718	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
340177003719	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
340177003720	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
340177003721	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
340177003722	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
340177003723	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
340177003724	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
340177003725	SurA N-terminal domain; Region: SurA_N_3; cl07813
340177003726	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
340177003727	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
340177003728	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
340177003729	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
340177003730	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
340177003731	GIY-YIG motif/motif A; other site
340177003732	putative active site [active]
340177003733	putative metal binding site [ion binding]; other site
340177003734	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
340177003735	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
340177003736	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
340177003737	P loop; other site
340177003738	GTP binding site [chemical binding]; other site
340177003739	thiamine monophosphate kinase; Provisional; Region: PRK05731
340177003740	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
340177003741	ATP binding site [chemical binding]; other site
340177003742	dimerization interface [polypeptide binding]; other site
340177003743	Flagellin N-methylase; Region: FliB; pfam03692
340177003744	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
340177003745	pantothenate kinase; Reviewed; Region: PRK13320
340177003746	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
340177003747	active site
340177003748	dimer interface [polypeptide binding]; other site
340177003749	metal binding site [ion binding]; metal-binding site
340177003750	shikimate kinase; Reviewed; Region: aroK; PRK00131
340177003751	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
340177003752	ADP binding site [chemical binding]; other site
340177003753	magnesium binding site [ion binding]; other site
340177003754	putative shikimate binding site; other site
340177003755	Divergent AAA domain; Region: AAA_4; pfam04326
340177003756	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
340177003757	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
340177003758	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
340177003759	heterodimer interface [polypeptide binding]; other site
340177003760	substrate interaction site [chemical binding]; other site
340177003761	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
340177003762	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
340177003763	active site
340177003764	substrate binding site [chemical binding]; other site
340177003765	coenzyme B12 binding site [chemical binding]; other site
340177003766	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
340177003767	B12 binding site [chemical binding]; other site
340177003768	cobalt ligand [ion binding]; other site
340177003769	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
340177003770	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
340177003771	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
340177003772	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
340177003773	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
340177003774	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
340177003775	Predicted ATPase [General function prediction only]; Region: COG4637
340177003776	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177003777	Walker A/P-loop; other site
340177003778	ATP binding site [chemical binding]; other site
340177003779	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177003780	Walker B; other site
340177003781	D-loop; other site
340177003782	H-loop/switch region; other site
340177003783	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
340177003784	Nif-specific regulatory protein; Region: nifA; TIGR01817
340177003785	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
340177003786	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177003787	Walker A motif; other site
340177003788	ATP binding site [chemical binding]; other site
340177003789	Walker B motif; other site
340177003790	arginine finger; other site
340177003791	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
340177003792	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
340177003793	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
340177003794	active site
340177003795	catalytic residues [active]
340177003796	metal binding site [ion binding]; metal-binding site
340177003797	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
340177003798	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
340177003799	molybdenum-pterin binding domain; Region: Mop; TIGR00638
340177003800	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
340177003801	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
340177003802	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
340177003803	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
340177003804	active site
340177003805	catalytic tetrad [active]
340177003806	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
340177003807	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
340177003808	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
340177003809	Ligand Binding Site [chemical binding]; other site
340177003810	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
340177003811	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177003812	membrane ATPase/protein kinase; Provisional; Region: PRK09435
340177003813	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
340177003814	Walker A; other site
340177003815	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
340177003816	G4 box; other site
340177003817	G5 box; other site
340177003818	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
340177003819	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003820	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003821	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003822	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003823	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003824	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003825	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
340177003826	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
340177003827	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
340177003828	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
340177003829	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
340177003830	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
340177003831	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
340177003832	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003833	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003834	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003835	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003836	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003837	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003838	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003839	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003840	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003841	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003842	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003843	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003844	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003845	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003846	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003847	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003848	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003849	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003850	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003851	VCBS repeat; Region: VCBS_repeat; TIGR01965
340177003852	Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237
340177003853	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177003854	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
340177003855	nitrogenase reductase; Reviewed; Region: nifH; PRK13235
340177003856	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
340177003857	Nucleotide-binding sites [chemical binding]; other site
340177003858	Walker A motif; other site
340177003859	Switch I region of nucleotide binding site; other site
340177003860	Fe4S4 binding sites [ion binding]; other site
340177003861	Switch II region of nucleotide binding site; other site
340177003862	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
340177003863	Nitrogen regulatory protein P-II; Region: P-II; smart00938
340177003864	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
340177003865	Nitrogen regulatory protein P-II; Region: P-II; smart00938
340177003866	nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284
340177003867	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
340177003868	MoFe protein alpha/beta subunit interactions; other site
340177003869	Alpha subunit P cluster binding residues; other site
340177003870	FeMoco binding residues [chemical binding]; other site
340177003871	MoFe protein alpha subunit/Fe protein contacts; other site
340177003872	MoFe protein dimer/ dimer interactions; other site
340177003873	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
340177003874	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
340177003875	MoFe protein beta/alpha subunit interactions; other site
340177003876	Beta subunit P cluster binding residues; other site
340177003877	MoFe protein beta subunit/Fe protein contacts; other site
340177003878	MoFe protein dimer/ dimer interactions; other site
340177003879	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
340177003880	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
340177003881	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
340177003882	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
340177003883	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
340177003884	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177003885	FeS/SAM binding site; other site
340177003886	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
340177003887	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
340177003888	dimer interface [polypeptide binding]; other site
340177003889	[2Fe-2S] cluster binding site [ion binding]; other site
340177003890	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
340177003891	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
340177003892	Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102
340177003893	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
340177003894	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
340177003895	ligand binding site [chemical binding]; other site
340177003896	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177003897	binding surface
340177003898	TPR repeat; Region: TPR_11; pfam13414
340177003899	TPR motif; other site
340177003900	TPR repeat; Region: TPR_11; pfam13414
340177003901	Predicted membrane protein [Function unknown]; Region: COG2855
340177003902	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
340177003903	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
340177003904	homodimer interface [polypeptide binding]; other site
340177003905	substrate-cofactor binding pocket; other site
340177003906	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177003907	catalytic residue [active]
340177003908	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
340177003909	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
340177003910	dimer interface [polypeptide binding]; other site
340177003911	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177003912	catalytic residue [active]
340177003913	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
340177003914	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340177003915	non-specific DNA binding site [nucleotide binding]; other site
340177003916	salt bridge; other site
340177003917	sequence-specific DNA binding site [nucleotide binding]; other site
340177003918	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
340177003919	serine O-acetyltransferase; Region: cysE; TIGR01172
340177003920	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
340177003921	trimer interface [polypeptide binding]; other site
340177003922	active site
340177003923	substrate binding site [chemical binding]; other site
340177003924	CoA binding site [chemical binding]; other site
340177003925	KilA-N domain; Region: KilA-N; pfam04383
340177003926	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
340177003927	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
340177003928	homodimer interface [polypeptide binding]; other site
340177003929	substrate-cofactor binding pocket; other site
340177003930	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177003931	catalytic residue [active]
340177003932	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
340177003933	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
340177003934	thiS-thiF/thiG interaction site; other site
340177003935	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
340177003936	ThiS interaction site; other site
340177003937	putative active site [active]
340177003938	tetramer interface [polypeptide binding]; other site
340177003939	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177003940	Radical SAM superfamily; Region: Radical_SAM; pfam04055
340177003941	FeS/SAM binding site; other site
340177003942	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
340177003943	clan AA aspartic protease, AF_0612 family; Region: clan_AA_DTGF; TIGR03698
340177003944	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
340177003945	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
340177003946	ATP binding site [chemical binding]; other site
340177003947	substrate interface [chemical binding]; other site
340177003948	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
340177003949	active site residue [active]
340177003950	Protein of unknown function (DUF1778); Region: DUF1778; cl01845
340177003951	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340177003952	Coenzyme A binding pocket [chemical binding]; other site
340177003953	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340177003954	non-specific DNA binding site [nucleotide binding]; other site
340177003955	salt bridge; other site
340177003956	sequence-specific DNA binding site [nucleotide binding]; other site
340177003957	HipA N-terminal domain; Region: Couple_hipA; pfam13657
340177003958	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
340177003959	HipA-like N-terminal domain; Region: HipA_N; pfam07805
340177003960	HipA-like C-terminal domain; Region: HipA_C; pfam07804
340177003961	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
340177003962	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
340177003963	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
340177003964	ferredoxin; Provisional; Region: PRK06273
340177003965	NAD synthetase; Provisional; Region: PRK13980
340177003966	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
340177003967	homodimer interface [polypeptide binding]; other site
340177003968	NAD binding pocket [chemical binding]; other site
340177003969	ATP binding pocket [chemical binding]; other site
340177003970	Mg binding site [ion binding]; other site
340177003971	active-site loop [active]
340177003972	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
340177003973	Peptidase family M23; Region: Peptidase_M23; pfam01551
340177003974	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
340177003975	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
340177003976	hinge; other site
340177003977	active site
340177003978	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cd00562
340177003979	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
340177003980	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
340177003981	substrate binding site [chemical binding]; other site
340177003982	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
340177003983	substrate binding site [chemical binding]; other site
340177003984	ligand binding site [chemical binding]; other site
340177003985	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
340177003986	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
340177003987	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
340177003988	histidinol dehydrogenase; Region: hisD; TIGR00069
340177003989	NAD binding site [chemical binding]; other site
340177003990	dimerization interface [polypeptide binding]; other site
340177003991	product binding site; other site
340177003992	substrate binding site [chemical binding]; other site
340177003993	zinc binding site [ion binding]; other site
340177003994	catalytic residues [active]
340177003995	rod shape-determining protein MreB; Provisional; Region: PRK13930
340177003996	MreB and similar proteins; Region: MreB_like; cd10225
340177003997	nucleotide binding site [chemical binding]; other site
340177003998	Mg binding site [ion binding]; other site
340177003999	putative protofilament interaction site [polypeptide binding]; other site
340177004000	RodZ interaction site [polypeptide binding]; other site
340177004001	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
340177004002	putative active site [active]
340177004003	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
340177004004	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
340177004005	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
340177004006	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
340177004007	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
340177004008	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
340177004009	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
340177004010	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177004011	catalytic residue [active]
340177004012	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
340177004013	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
340177004014	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
340177004015	catalytic site [active]
340177004016	Rrf2 family protein; Region: rrf2_super; TIGR00738
340177004017	Transcriptional regulator; Region: Rrf2; pfam02082
340177004018	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
340177004019	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
340177004020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177004021	ABC transporter signature motif; other site
340177004022	Walker B; other site
340177004023	D-loop; other site
340177004024	H-loop/switch region; other site
340177004025	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
340177004026	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177004027	AAA domain; Region: AAA_21; pfam13304
340177004028	Walker A/P-loop; other site
340177004029	ATP binding site [chemical binding]; other site
340177004030	AAA domain; Region: AAA_21; pfam13304
340177004031	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
340177004032	ABC transporter signature motif; other site
340177004033	Walker B; other site
340177004034	D-loop; other site
340177004035	H-loop/switch region; other site
340177004036	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
340177004037	oligomerisation interface [polypeptide binding]; other site
340177004038	mobile loop; other site
340177004039	roof hairpin; other site
340177004040	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
340177004041	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
340177004042	ring oligomerisation interface [polypeptide binding]; other site
340177004043	ATP/Mg binding site [chemical binding]; other site
340177004044	stacking interactions; other site
340177004045	hinge regions; other site
340177004046	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
340177004047	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
340177004048	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
340177004049	active site
340177004050	HicB family; Region: HicB; pfam05534
340177004051	Protein of unknown function (DUF433); Region: DUF433; pfam04255
340177004052	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
340177004053	Ligand Binding Site [chemical binding]; other site
340177004054	CAAX protease self-immunity; Region: Abi; pfam02517
340177004055	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
340177004056	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
340177004057	substrate binding site [chemical binding]; other site
340177004058	active site
340177004059	catalytic residues [active]
340177004060	heterodimer interface [polypeptide binding]; other site
340177004061	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
340177004062	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
340177004063	Probable Catalytic site; other site
340177004064	metal-binding site
340177004065	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
340177004066	MutS domain I; Region: MutS_I; pfam01624
340177004067	MutS domain II; Region: MutS_II; pfam05188
340177004068	MutS domain III; Region: MutS_III; pfam05192
340177004069	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
340177004070	Walker A/P-loop; other site
340177004071	ATP binding site [chemical binding]; other site
340177004072	Q-loop/lid; other site
340177004073	ABC transporter signature motif; other site
340177004074	Walker B; other site
340177004075	D-loop; other site
340177004076	H-loop/switch region; other site
340177004077	PemK-like protein; Region: PemK; pfam02452
340177004078	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
340177004079	B12 binding site [chemical binding]; other site
340177004080	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
340177004081	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177004082	FeS/SAM binding site; other site
340177004083	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
340177004084	Putative addiction module component; Region: Unstab_antitox; pfam09720
340177004085	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
340177004086	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
340177004087	oligomeric interface; other site
340177004088	putative active site [active]
340177004089	homodimer interface [polypeptide binding]; other site
340177004090	hypothetical protein; Provisional; Region: PRK09256
340177004091	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
340177004092	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
340177004093	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
340177004094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177004095	Walker A/P-loop; other site
340177004096	ATP binding site [chemical binding]; other site
340177004097	Q-loop/lid; other site
340177004098	ABC transporter signature motif; other site
340177004099	Walker B; other site
340177004100	D-loop; other site
340177004101	H-loop/switch region; other site
340177004102	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
340177004103	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
340177004104	DNA binding residues [nucleotide binding]
340177004105	Bacteriochlorophyll A protein; Region: BChl_A; pfam02327
340177004106	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
340177004107	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
340177004108	putative active site [active]
340177004109	catalytic triad [active]
340177004110	putative dimer interface [polypeptide binding]; other site
340177004111	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177004112	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
340177004113	Walker A motif; other site
340177004114	ATP binding site [chemical binding]; other site
340177004115	Walker B motif; other site
340177004116	arginine finger; other site
340177004117	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
340177004118	Sporulation related domain; Region: SPOR; cl10051
340177004119	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14616
340177004120	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
340177004121	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
340177004122	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
340177004123	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
340177004124	Protein of unknown function (DUF1207); Region: DUF1207; pfam06727
340177004125	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
340177004126	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
340177004127	Ligand Binding Site [chemical binding]; other site
340177004128	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340177004129	putative substrate translocation pore; other site
340177004130	excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671
340177004131	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
340177004132	GIY-YIG motif/motif A; other site
340177004133	active site
340177004134	catalytic site [active]
340177004135	putative DNA binding site [nucleotide binding]; other site
340177004136	metal binding site [ion binding]; metal-binding site
340177004137	UvrB/uvrC motif; Region: UVR; pfam02151
340177004138	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
340177004139	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
340177004140	DNA binding site [nucleotide binding]
340177004141	Predicted periplasmic protein [Function unknown]; Region: COG3698
340177004142	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
340177004143	TPR repeat; Region: TPR_11; pfam13414
340177004144	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177004145	binding surface
340177004146	TPR motif; other site
340177004147	Tetratricopeptide repeat; Region: TPR_16; pfam13432
340177004148	TPR repeat; Region: TPR_11; pfam13414
340177004149	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177004150	binding surface
340177004151	TPR motif; other site
340177004152	TPR repeat; Region: TPR_11; pfam13414
340177004153	TPR repeat; Region: TPR_11; pfam13414
340177004154	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177004155	binding surface
340177004156	TPR motif; other site
340177004157	TPR repeat; Region: TPR_11; pfam13414
340177004158	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177004159	binding surface
340177004160	TPR motif; other site
340177004161	TPR repeat; Region: TPR_11; pfam13414
340177004162	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177004163	binding surface
340177004164	TPR motif; other site
340177004165	TPR repeat; Region: TPR_11; pfam13414
340177004166	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
340177004167	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
340177004168	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
340177004169	shikimate binding site; other site
340177004170	NAD(P) binding site [chemical binding]; other site
340177004171	lipoprotein signal peptidase; Provisional; Region: PRK14787
340177004172	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
340177004173	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
340177004174	active site
340177004175	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
340177004176	binding surface
340177004177	TPR motif; other site
340177004178	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
340177004179	active site
340177004180	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
340177004181	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
340177004182	catalytic residue [active]
340177004183	purine nucleoside phosphorylase; Provisional; Region: PRK08202
340177004184	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
340177004185	PIN domain; Region: PIN_3; cl17397
340177004186	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
340177004187	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
340177004188	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
340177004189	Low-spin heme binding site [chemical binding]; other site
340177004190	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
340177004191	D-pathway; other site
340177004192	Putative water exit pathway; other site
340177004193	Binuclear center (active site) [active]
340177004194	K-pathway; other site
340177004195	Putative proton exit pathway; other site
340177004196	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
340177004197	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
340177004198	4Fe-4S binding domain; Region: Fer4_5; pfam12801
340177004199	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
340177004200	Protein of unknown function (DUF497); Region: DUF497; pfam04365
340177004201	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
340177004202	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
340177004203	Catalytic domain of Protein Kinases; Region: PKc; cd00180
340177004204	active site
340177004205	ATP binding site [chemical binding]; other site
340177004206	substrate binding site [chemical binding]; other site
340177004207	activation loop (A-loop); other site
340177004208	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
340177004209	FIC domain binding interface [polypeptide binding]; other site
340177004210	FixH; Region: FixH; pfam05751
340177004211	YtkA-like; Region: YtkA; pfam13115
340177004212	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
340177004213	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
340177004214	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
340177004215	metal-binding site [ion binding]
340177004216	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
340177004217	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
340177004218	Soluble P-type ATPase [General function prediction only]; Region: COG4087
340177004219	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
340177004220	Family description; Region: DsbD_2; pfam13386
340177004221	PIN domain; Region: PIN; pfam01850
340177004222	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
340177004223	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
340177004224	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
340177004225	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
340177004226	ligand binding site [chemical binding]; other site
340177004227	NAD binding site [chemical binding]; other site
340177004228	dimerization interface [polypeptide binding]; other site
340177004229	catalytic site [active]
340177004230	ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879
340177004231	L-serine binding site [chemical binding]; other site
340177004232	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
340177004233	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
340177004234	P loop; other site
340177004235	Nucleotide binding site [chemical binding]; other site
340177004236	DTAP/Switch II; other site
340177004237	Switch I; other site
340177004238	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
340177004239	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
340177004240	N-acetyl-D-glucosamine binding site [chemical binding]; other site
340177004241	catalytic residue [active]
340177004242	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
340177004243	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
340177004244	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
340177004245	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
340177004246	dimerization interface 3.5A [polypeptide binding]; other site
340177004247	active site
340177004248	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
340177004249	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
340177004250	active site
340177004251	catalytic site [active]
340177004252	Ribokinase-like subgroup C.  Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946
340177004253	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
340177004254	substrate binding site [chemical binding]; other site
340177004255	ATP binding site [chemical binding]; other site
340177004256	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
340177004257	active site
340177004258	NTP binding site [chemical binding]; other site
340177004259	metal binding triad [ion binding]; metal-binding site
340177004260	antibiotic binding site [chemical binding]; other site
340177004261	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
340177004262	Na binding site [ion binding]; other site
340177004263	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
340177004264	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340177004265	non-specific DNA binding site [nucleotide binding]; other site
340177004266	salt bridge; other site
340177004267	sequence-specific DNA binding site [nucleotide binding]; other site
340177004268	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
340177004269	active site
340177004270	metal binding site [ion binding]; metal-binding site
340177004271	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
340177004272	oligomeric interface; other site
340177004273	putative active site [active]
340177004274	homodimer interface [polypeptide binding]; other site
340177004275	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
340177004276	putative active site [active]
340177004277	Tsp45I type II restriction enzyme; Region: Tsp45I; pfam06300
340177004278	DNA methylase; Region: N6_N4_Mtase; pfam01555
340177004279	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
340177004280	Maf-like protein; Region: Maf; pfam02545
340177004281	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
340177004282	active site
340177004283	dimer interface [polypeptide binding]; other site
340177004284	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
340177004285	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
340177004286	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
340177004287	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
340177004288	anti sigma factor interaction site; other site
340177004289	regulatory phosphorylation site [posttranslational modification]; other site
340177004290	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
340177004291	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
340177004292	transmembrane helices; other site
340177004293	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
340177004294	Domain of unknown function (DUF389); Region: DUF389; pfam04087
340177004295	putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862
340177004296	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
340177004297	Cl- selectivity filter; other site
340177004298	Cl- binding residues [ion binding]; other site
340177004299	pore gating glutamate residue; other site
340177004300	dimer interface [polypeptide binding]; other site
340177004301	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
340177004302	The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633
340177004303	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
340177004304	DNA methylase; Region: N6_N4_Mtase; pfam01555
340177004305	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340177004306	S-adenosylmethionine binding site [chemical binding]; other site
340177004307	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
340177004308	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
340177004309	active site
340177004310	HIGH motif; other site
340177004311	KMSKS motif; other site
340177004312	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
340177004313	tRNA binding surface [nucleotide binding]; other site
340177004314	anticodon binding site; other site
340177004315	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
340177004316	dimer interface [polypeptide binding]; other site
340177004317	putative tRNA-binding site [nucleotide binding]; other site
340177004318	PSP1 C-terminal conserved region; Region: PSP1; pfam04468
340177004319	Peptidase family M50; Region: Peptidase_M50; pfam02163
340177004320	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709
340177004321	active site
340177004322	putative substrate binding region [chemical binding]; other site
340177004323	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
340177004324	GAF domain; Region: GAF; pfam01590
340177004325	GAF domain; Region: GAF_2; pfam13185
340177004326	HlyD family secretion protein; Region: HlyD_3; pfam13437
340177004327	HlyD family secretion protein; Region: HlyD_3; pfam13437
340177004328	HlyD family secretion protein; Region: HlyD; pfam00529
340177004329	HlyD family secretion protein; Region: HlyD_3; pfam13437
340177004330	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
340177004331	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
340177004332	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
340177004333	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
340177004334	NAD binding site [chemical binding]; other site
340177004335	homotetramer interface [polypeptide binding]; other site
340177004336	homodimer interface [polypeptide binding]; other site
340177004337	substrate binding site [chemical binding]; other site
340177004338	active site
340177004339	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
340177004340	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
340177004341	P loop; other site
340177004342	Nucleotide binding site [chemical binding]; other site
340177004343	DTAP/Switch II; other site
340177004344	Switch I; other site
340177004345	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
340177004346	FMN binding site [chemical binding]; other site
340177004347	dimer interface [polypeptide binding]; other site
340177004348	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
340177004349	Flavoprotein; Region: Flavoprotein; cl08021
340177004350	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
340177004351	Part of AAA domain; Region: AAA_19; pfam13245
340177004352	Family description; Region: UvrD_C_2; pfam13538
340177004353	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347
340177004354	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
340177004355	active site
340177004356	catalytic site [active]
340177004357	Uncharacterized conserved protein [Function unknown]; Region: COG0432
340177004358	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
340177004359	tetramer interfaces [polypeptide binding]; other site
340177004360	binuclear metal-binding site [ion binding]; other site
340177004361	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
340177004362	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
340177004363	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
340177004364	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
340177004365	Flavodoxin domain; Region: Flavodoxin_5; cl17428
340177004366	chaperone protein DnaJ; Provisional; Region: PRK14281
340177004367	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
340177004368	HSP70 interaction site [polypeptide binding]; other site
340177004369	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
340177004370	substrate binding site [polypeptide binding]; other site
340177004371	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
340177004372	Zn binding sites [ion binding]; other site
340177004373	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
340177004374	dimer interface [polypeptide binding]; other site
340177004375	heat shock protein GrpE; Provisional; Region: PRK14141
340177004376	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
340177004377	dimer interface [polypeptide binding]; other site
340177004378	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
340177004379	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
340177004380	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
340177004381	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
340177004382	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
340177004383	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340177004384	S-adenosylmethionine binding site [chemical binding]; other site
340177004385	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
340177004386	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
340177004387	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
340177004388	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
340177004389	catalytic triad [active]
340177004390	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
340177004391	FAD binding domain; Region: FAD_binding_4; pfam01565
340177004392	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
340177004393	Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
340177004394	putative heme binding site [chemical binding]; other site
340177004395	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
340177004396	putative catalytic site [active]
340177004397	putative metal binding site [ion binding]; other site
340177004398	putative phosphate binding site [ion binding]; other site
340177004399	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
340177004400	oligomeric interface; other site
340177004401	putative active site [active]
340177004402	homodimer interface [polypeptide binding]; other site
340177004403	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
340177004404	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
340177004405	ATP binding site [chemical binding]; other site
340177004406	active site
340177004407	substrate binding site [chemical binding]; other site
340177004408	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
340177004409	transketolase; Reviewed; Region: PRK05899
340177004410	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
340177004411	TPP-binding site [chemical binding]; other site
340177004412	dimer interface [polypeptide binding]; other site
340177004413	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
340177004414	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340177004415	S-adenosylmethionine binding site [chemical binding]; other site
340177004416	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
340177004417	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
340177004418	active site
340177004419	(T/H)XGH motif; other site
340177004420	aspartate aminotransferase; Provisional; Region: PRK05764
340177004421	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
340177004422	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177004423	homodimer interface [polypeptide binding]; other site
340177004424	catalytic residue [active]
340177004425	Fic family protein [Function unknown]; Region: COG3177
340177004426	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
340177004427	Fic/DOC family; Region: Fic; pfam02661
340177004428	KilA-N domain; Region: KilA-N; pfam04383
340177004429	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
340177004430	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177004431	Walker A/P-loop; other site
340177004432	ATP binding site [chemical binding]; other site
340177004433	Q-loop/lid; other site
340177004434	ABC transporter signature motif; other site
340177004435	Walker B; other site
340177004436	D-loop; other site
340177004437	H-loop/switch region; other site
340177004438	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
340177004439	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
340177004440	homotetramer interface [polypeptide binding]; other site
340177004441	FMN binding site [chemical binding]; other site
340177004442	homodimer contacts [polypeptide binding]; other site
340177004443	putative active site [active]
340177004444	putative substrate binding site [chemical binding]; other site
340177004445	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
340177004446	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
340177004447	substrate binding pocket [chemical binding]; other site
340177004448	chain length determination region; other site
340177004449	substrate-Mg2+ binding site; other site
340177004450	catalytic residues [active]
340177004451	aspartate-rich region 1; other site
340177004452	active site lid residues [active]
340177004453	aspartate-rich region 2; other site
340177004454	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
340177004455	DNA protecting protein DprA; Region: dprA; TIGR00732
340177004456	periplasmic chaperone; Provisional; Region: PRK10780
340177004457	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
340177004458	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
340177004459	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
340177004460	tetramerization interface [polypeptide binding]; other site
340177004461	active site
340177004462	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
340177004463	Substrate binding site; other site
340177004464	Mg++ binding site; other site
340177004465	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177004466	binding surface
340177004467	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177004468	TPR motif; other site
340177004469	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177004470	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177004471	binding surface
340177004472	TPR motif; other site
340177004473	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177004474	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177004475	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177004476	binding surface
340177004477	TPR motif; other site
340177004478	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177004479	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177004480	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
340177004481	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
340177004482	active site
340177004483	metal binding site [ion binding]; metal-binding site
340177004484	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
340177004485	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
340177004486	catalytic site [active]
340177004487	G-X2-G-X-G-K; other site
340177004488	hypothetical protein; Provisional; Region: PRK11820
340177004489	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
340177004490	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
340177004491	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
340177004492	16S/18S rRNA binding site [nucleotide binding]; other site
340177004493	S13e-L30e interaction site [polypeptide binding]; other site
340177004494	25S rRNA binding site [nucleotide binding]; other site
340177004495	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
340177004496	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
340177004497	active site
340177004498	Riboflavin kinase; Region: Flavokinase; pfam01687
340177004499	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
340177004500	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
340177004501	RNA binding site [nucleotide binding]; other site
340177004502	active site
340177004503	Ribosome-binding factor A; Region: RBFA; pfam02033
340177004504	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
340177004505	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
340177004506	translation initiation factor IF-2; Region: IF-2; TIGR00487
340177004507	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
340177004508	G1 box; other site
340177004509	putative GEF interaction site [polypeptide binding]; other site
340177004510	GTP/Mg2+ binding site [chemical binding]; other site
340177004511	Switch I region; other site
340177004512	G2 box; other site
340177004513	G3 box; other site
340177004514	Switch II region; other site
340177004515	G4 box; other site
340177004516	G5 box; other site
340177004517	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
340177004518	Translation-initiation factor 2; Region: IF-2; pfam11987
340177004519	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
340177004520	NusA N-terminal domain; Region: NusA_N; pfam08529
340177004521	transcription termination factor NusA; Region: NusA; TIGR01953
340177004522	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
340177004523	RNA binding site [nucleotide binding]; other site
340177004524	NusA-like KH domain; Region: KH_5; pfam13184
340177004525	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
340177004526	G-X-X-G motif; other site
340177004527	hypothetical protein; Provisional; Region: PRK14641
340177004528	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
340177004529	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
340177004530	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
340177004531	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
340177004532	motif 1; other site
340177004533	dimer interface [polypeptide binding]; other site
340177004534	active site
340177004535	motif 2; other site
340177004536	motif 3; other site
340177004537	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
340177004538	anticodon binding site; other site
340177004539	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
340177004540	active site
340177004541	phosphorylation site [posttranslational modification]
340177004542	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
340177004543	Fic/DOC family; Region: Fic; pfam02661
340177004544	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
340177004545	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
340177004546	CAAX protease self-immunity; Region: Abi; pfam02517
340177004547	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340177004548	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
340177004549	putative ADP-binding pocket [chemical binding]; other site
340177004550	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340177004551	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
340177004552	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
340177004553	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
340177004554	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
340177004555	putative ADP-binding pocket [chemical binding]; other site
340177004556	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340177004557	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
340177004558	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340177004559	putative ADP-binding pocket [chemical binding]; other site
340177004560	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340177004561	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
340177004562	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
340177004563	active site
340177004564	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
340177004565	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
340177004566	active site
340177004567	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
340177004568	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
340177004569	trimer interface [polypeptide binding]; other site
340177004570	active site
340177004571	substrate binding site [chemical binding]; other site
340177004572	CoA binding site [chemical binding]; other site
340177004573	Methyltransferase domain; Region: Methyltransf_24; pfam13578
340177004574	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340177004575	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
340177004576	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340177004577	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
340177004578	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
340177004579	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
340177004580	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
340177004581	Walker A/P-loop; other site
340177004582	ATP binding site [chemical binding]; other site
340177004583	Q-loop/lid; other site
340177004584	ABC transporter signature motif; other site
340177004585	Walker B; other site
340177004586	D-loop; other site
340177004587	H-loop/switch region; other site
340177004588	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
340177004589	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
340177004590	putative acyl-acceptor binding pocket; other site
340177004591	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
340177004592	Clp amino terminal domain; Region: Clp_N; pfam02861
340177004593	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177004594	Walker A motif; other site
340177004595	ATP binding site [chemical binding]; other site
340177004596	Walker B motif; other site
340177004597	arginine finger; other site
340177004598	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177004599	Walker A motif; other site
340177004600	ATP binding site [chemical binding]; other site
340177004601	Walker B motif; other site
340177004602	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
340177004603	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
340177004604	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
340177004605	addiction module antidote protein, HigA family; Region: antidote_HigA; TIGR02607
340177004606	sequence-specific DNA binding site [nucleotide binding]; other site
340177004607	salt bridge; other site
340177004608	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
340177004609	Uncharacterized conserved protein [Function unknown]; Region: COG1434
340177004610	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
340177004611	putative active site [active]
340177004612	hybrid cluster protein; Provisional; Region: PRK05290
340177004613	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
340177004614	ACS interaction site; other site
340177004615	CODH interaction site; other site
340177004616	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
340177004617	hybrid metal cluster; other site
340177004618	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177004619	TPR motif; other site
340177004620	TPR repeat; Region: TPR_11; pfam13414
340177004621	binding surface
340177004622	4Fe-4S binding domain; Region: Fer4_6; pfam12837
340177004623	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
340177004624	Rrf2 family protein; Region: rrf2_super; TIGR00738
340177004625	Transcriptional regulator; Region: Rrf2; pfam02082
340177004626	YcfA-like protein; Region: YcfA; pfam07927
340177004627	Membrane protein of unknown function; Region: DUF360; pfam04020
340177004628	SET domain; Region: SET; pfam00856
340177004629	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
340177004630	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
340177004631	putative NAD(P) binding site [chemical binding]; other site
340177004632	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
340177004633	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
340177004634	Walker A/P-loop; other site
340177004635	ATP binding site [chemical binding]; other site
340177004636	Q-loop/lid; other site
340177004637	ABC transporter signature motif; other site
340177004638	Walker B; other site
340177004639	D-loop; other site
340177004640	H-loop/switch region; other site
340177004641	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
340177004642	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
340177004643	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
340177004644	TM-ABC transporter signature motif; other site
340177004645	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
340177004646	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
340177004647	CHAT domain; Region: CHAT; pfam12770
340177004648	AAA ATPase domain; Region: AAA_16; pfam13191
340177004649	Archaeal ATPase; Region: Arch_ATPase; pfam01637
340177004650	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177004651	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177004652	TPR motif; other site
340177004653	binding surface
340177004654	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177004655	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177004656	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177004657	binding surface
340177004658	TPR motif; other site
340177004659	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177004660	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177004661	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177004662	binding surface
340177004663	TPR motif; other site
340177004664	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177004665	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177004666	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177004667	binding surface
340177004668	TPR motif; other site
340177004669	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177004670	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177004671	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
340177004672	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
340177004673	Transposase; Region: DDE_Tnp_ISL3; pfam01610
340177004674	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
340177004675	hypothetical protein; Reviewed; Region: PRK00024
340177004676	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
340177004677	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
340177004678	MPN+ (JAMM) motif; other site
340177004679	Zinc-binding site [ion binding]; other site
340177004680	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
340177004681	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
340177004682	active site
340177004683	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
340177004684	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
340177004685	domain interfaces; other site
340177004686	active site
340177004687	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
340177004688	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
340177004689	tRNA; other site
340177004690	putative tRNA binding site [nucleotide binding]; other site
340177004691	putative NADP binding site [chemical binding]; other site
340177004692	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
340177004693	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
340177004694	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
340177004695	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
340177004696	putative GEF interaction site [polypeptide binding]; other site
340177004697	G1 box; other site
340177004698	GTP/Mg2+ binding site [chemical binding]; other site
340177004699	Switch I region; other site
340177004700	G2 box; other site
340177004701	G3 box; other site
340177004702	Switch II region; other site
340177004703	G4 box; other site
340177004704	G5 box; other site
340177004705	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
340177004706	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
340177004707	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
340177004708	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
340177004709	Tetramer interface [polypeptide binding]; other site
340177004710	active site
340177004711	FMN-binding site [chemical binding]; other site
340177004712	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
340177004713	dimer interface [polypeptide binding]; other site
340177004714	allosteric magnesium binding site [ion binding]; other site
340177004715	active site
340177004716	aspartate-rich active site metal binding site; other site
340177004717	Schiff base residues; other site
340177004718	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
340177004719	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
340177004720	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
340177004721	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
340177004722	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
340177004723	active site
340177004724	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
340177004725	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
340177004726	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340177004727	ATP binding site [chemical binding]; other site
340177004728	putative Mg++ binding site [ion binding]; other site
340177004729	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
340177004730	BRO family, N-terminal domain; Region: Bro-N; pfam02498
340177004731	HsdM N-terminal domain; Region: HsdM_N; pfam12161
340177004732	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
340177004733	Methyltransferase domain; Region: Methyltransf_26; pfam13659
340177004734	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
340177004735	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
340177004736	Transposase IS200 like; Region: Y1_Tnp; cl00848
340177004737	Preprotein translocase SecG subunit; Region: SecG; cl09123
340177004738	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
340177004739	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
340177004740	putative active site pocket [active]
340177004741	4-fold oligomerization interface [polypeptide binding]; other site
340177004742	metal binding residues [ion binding]; metal-binding site
340177004743	3-fold/trimer interface [polypeptide binding]; other site
340177004744	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
340177004745	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
340177004746	B12 binding site [chemical binding]; other site
340177004747	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
340177004748	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177004749	FeS/SAM binding site; other site
340177004750	bacteriochlorophyll c synthase; Provisional; Region: PRK12392
340177004751	UbiA prenyltransferase family; Region: UbiA; pfam01040
340177004752	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
340177004753	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
340177004754	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
340177004755	heme pocket [chemical binding]; other site
340177004756	putative active site [active]
340177004757	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
340177004758	PAS fold; Region: PAS_3; pfam08447
340177004759	putative active site [active]
340177004760	heme pocket [chemical binding]; other site
340177004761	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
340177004762	PAS fold; Region: PAS_3; pfam08447
340177004763	putative active site [active]
340177004764	heme pocket [chemical binding]; other site
340177004765	PAS domain S-box; Region: sensory_box; TIGR00229
340177004766	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
340177004767	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
340177004768	putative active site [active]
340177004769	heme pocket [chemical binding]; other site
340177004770	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
340177004771	putative active site [active]
340177004772	heme pocket [chemical binding]; other site
340177004773	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
340177004774	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
340177004775	dimer interface [polypeptide binding]; other site
340177004776	phosphorylation site [posttranslational modification]
340177004777	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
340177004778	ATP binding site [chemical binding]; other site
340177004779	Mg2+ binding site [ion binding]; other site
340177004780	G-X-G motif; other site
340177004781	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
340177004782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
340177004783	active site
340177004784	phosphorylation site [posttranslational modification]
340177004785	intermolecular recognition site; other site
340177004786	dimerization interface [polypeptide binding]; other site
340177004787	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
340177004788	DNA binding site [nucleotide binding]
340177004789	phosphodiesterase; Provisional; Region: PRK12704
340177004790	KH domain; Region: KH_1; pfam00013
340177004791	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
340177004792	Zn2+ binding site [ion binding]; other site
340177004793	Mg2+ binding site [ion binding]; other site
340177004794	Cell division protein ZapA; Region: ZapA; pfam05164
340177004795	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
340177004796	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
340177004797	putative tRNA-binding site [nucleotide binding]; other site
340177004798	B3/4 domain; Region: B3_4; pfam03483
340177004799	tRNA synthetase B5 domain; Region: B5; smart00874
340177004800	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
340177004801	dimer interface [polypeptide binding]; other site
340177004802	motif 1; other site
340177004803	motif 3; other site
340177004804	motif 2; other site
340177004805	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
340177004806	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
340177004807	nudix motif; other site
340177004808	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
340177004809	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
340177004810	active site
340177004811	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
340177004812	S-adenosylmethionine synthetase; Validated; Region: PRK05250
340177004813	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
340177004814	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
340177004815	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
340177004816	Adenosylhomocysteinase; Provisional; Region: PTZ00075
340177004817	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
340177004818	homotetramer interface [polypeptide binding]; other site
340177004819	ligand binding site [chemical binding]; other site
340177004820	catalytic site [active]
340177004821	NAD binding site [chemical binding]; other site
340177004822	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
340177004823	active site
340177004824	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
340177004825	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
340177004826	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
340177004827	TrkA-N domain; Region: TrkA_N; pfam02254
340177004828	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
340177004829	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
340177004830	putative transporter; Provisional; Region: PRK11660
340177004831	Sulfate transporter family; Region: Sulfate_transp; pfam00916
340177004832	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
340177004833	Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033
340177004834	putative catalytic residues [active]
340177004835	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
340177004836	trimer interface [polypeptide binding]; other site
340177004837	putative Zn binding site [ion binding]; other site
340177004838	Transposase; Region: DEDD_Tnp_IS110; pfam01548
340177004839	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
340177004840	Protein of unknown function (DUF972); Region: DUF972; pfam06156
340177004841	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
340177004842	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
340177004843	Family description; Region: VCBS; pfam13517
340177004844	Family description; Region: VCBS; pfam13517
340177004845	Family description; Region: VCBS; pfam13517
340177004846	Family description; Region: VCBS; pfam13517
340177004847	Family description; Region: VCBS; pfam13517
340177004848	Family description; Region: VCBS; pfam13517
340177004849	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177004850	Family description; Region: VCBS; pfam13517
340177004851	Family description; Region: VCBS; pfam13517
340177004852	Family description; Region: VCBS; pfam13517
340177004853	Family description; Region: VCBS; pfam13517
340177004854	Family description; Region: VCBS; pfam13517
340177004855	Family description; Region: VCBS; pfam13517
340177004856	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177004857	Protein of unknown function DUF45; Region: DUF45; pfam01863
340177004858	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
340177004859	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
340177004860	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898
340177004861	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
340177004862	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
340177004863	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
340177004864	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
340177004865	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
340177004866	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
340177004867	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
340177004868	FAD binding pocket [chemical binding]; other site
340177004869	FAD binding motif [chemical binding]; other site
340177004870	phosphate binding motif [ion binding]; other site
340177004871	beta-alpha-beta structure motif; other site
340177004872	NAD binding pocket [chemical binding]; other site
340177004873	Iron coordination center [ion binding]; other site
340177004874	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
340177004875	Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309
340177004876	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
340177004877	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
340177004878	putative NAD(P) binding site [chemical binding]; other site
340177004879	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
340177004880	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
340177004881	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
340177004882	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177004883	FeS/SAM binding site; other site
340177004884	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
340177004885	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
340177004886	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
340177004887	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
340177004888	Transposase; Region: DDE_Tnp_ISL3; pfam01610
340177004889	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
340177004890	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
340177004891	oligomer interface [polypeptide binding]; other site
340177004892	metal binding site [ion binding]; metal-binding site
340177004893	metal binding site [ion binding]; metal-binding site
340177004894	Cl binding site [ion binding]; other site
340177004895	aspartate ring; other site
340177004896	basic sphincter; other site
340177004897	putative hydrophobic gate; other site
340177004898	periplasmic entrance; other site
340177004899	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
340177004900	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
340177004901	tricarballylate utilization protein B; Provisional; Region: PRK15033
340177004902	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
340177004903	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
340177004904	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
340177004905	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
340177004906	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
340177004907	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
340177004908	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
340177004909	adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060
340177004910	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
340177004911	Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139
340177004912	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
340177004913	ATP-sulfurylase; Region: ATPS; cd00517
340177004914	active site
340177004915	HXXH motif; other site
340177004916	flexible loop; other site
340177004917	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
340177004918	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
340177004919	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
340177004920	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
340177004921	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340177004922	putative DNA binding site [nucleotide binding]; other site
340177004923	dimerization interface [polypeptide binding]; other site
340177004924	putative Zn2+ binding site [ion binding]; other site
340177004925	AsnC family; Region: AsnC_trans_reg; pfam01037
340177004926	phytoene desaturase; Region: phytoene_desat; TIGR02731
340177004927	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
340177004928	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
340177004929	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177004930	FeS/SAM binding site; other site
340177004931	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
340177004932	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
340177004933	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
340177004934	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
340177004935	Probable Catalytic site; other site
340177004936	chlorosome envelope protein H repeat; Region: rpt_csmH; TIGR03058
340177004937	chlorosome envelope protein H repeat; Region: rpt_csmH; TIGR03058
340177004938	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
340177004939	trimer interface [polypeptide binding]; other site
340177004940	active site
340177004941	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
340177004942	Family description; Region: VCBS; pfam13517
340177004943	Family description; Region: VCBS; pfam13517
340177004944	Family description; Region: VCBS; pfam13517
340177004945	Family description; Region: VCBS; pfam13517
340177004946	Family description; Region: VCBS; pfam13517
340177004947	Family description; Region: VCBS; pfam13517
340177004948	Family description; Region: VCBS; pfam13517
340177004949	Family description; Region: VCBS; pfam13517
340177004950	Family description; Region: VCBS; pfam13517
340177004951	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177004952	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177004953	NACHT domain; Region: NACHT; pfam05729
340177004954	Walker A/P-loop; other site
340177004955	ATP binding site [chemical binding]; other site
340177004956	ABC transporter signature motif; other site
340177004957	Walker B; other site
340177004958	D-loop; other site
340177004959	H-loop/switch region; other site
340177004960	TIGR02646 family protein; Region: TIGR02646
340177004961	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177004962	AAA domain; Region: AAA_21; pfam13304
340177004963	Walker A/P-loop; other site
340177004964	ATP binding site [chemical binding]; other site
340177004965	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
340177004966	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
340177004967	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
340177004968	catalytic triad [active]
340177004969	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
340177004970	nudix motif; other site
340177004971	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
340177004972	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
340177004973	putative active site [active]
340177004974	metal binding site [ion binding]; metal-binding site
340177004975	homodimer binding site [polypeptide binding]; other site
340177004976	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
340177004977	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
340177004978	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
340177004979	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
340177004980	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
340177004981	replicative DNA helicase; Region: DnaB; TIGR00665
340177004982	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
340177004983	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
340177004984	Walker A motif; other site
340177004985	ATP binding site [chemical binding]; other site
340177004986	Walker B motif; other site
340177004987	DNA binding loops [nucleotide binding]
340177004988	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340177004989	S-adenosylmethionine binding site [chemical binding]; other site
340177004990	AccI restriction endonuclease; Region: RE_AccI; pfam09545
340177004991	rad50; Region: rad50; TIGR00606
340177004992	Predicted ATPase [General function prediction only]; Region: COG4637
340177004993	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
340177004994	Flavoprotein; Region: Flavoprotein; pfam02441
340177004995	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
340177004996	Family of unknown function (DUF490); Region: DUF490; pfam04357
340177004997	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
340177004998	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
340177004999	active site
340177005000	nucleotide binding site [chemical binding]; other site
340177005001	HIGH motif; other site
340177005002	KMSKS motif; other site
340177005003	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
340177005004	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
340177005005	putative active site [active]
340177005006	putative metal binding site [ion binding]; other site
340177005007	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
340177005008	Predicted transcriptional regulator [Transcription]; Region: COG2944
340177005009	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340177005010	non-specific DNA binding site [nucleotide binding]; other site
340177005011	salt bridge; other site
340177005012	sequence-specific DNA binding site [nucleotide binding]; other site
340177005013	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
340177005014	magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031
340177005015	Walker A motif; other site
340177005016	ATP binding site [chemical binding]; other site
340177005017	Walker B motif; other site
340177005018	arginine finger; other site
340177005019	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
340177005020	metal ion-dependent adhesion site (MIDAS); other site
340177005021	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
340177005022	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
340177005023	Walker A motif; other site
340177005024	ATP binding site [chemical binding]; other site
340177005025	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
340177005026	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
340177005027	RNA binding surface [nucleotide binding]; other site
340177005028	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
340177005029	active site
340177005030	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
340177005031	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
340177005032	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
340177005033	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
340177005034	YtxH-like protein; Region: YtxH; pfam12732
340177005035	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
340177005036	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
340177005037	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
340177005038	cofactor binding site; other site
340177005039	DNA binding site [nucleotide binding]
340177005040	substrate interaction site [chemical binding]; other site
340177005041	Protein of unknown function DUF262; Region: DUF262; pfam03235
340177005042	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
340177005043	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
340177005044	hinge; other site
340177005045	active site
340177005046	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
340177005047	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
340177005048	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
340177005049	dimer interface [polypeptide binding]; other site
340177005050	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177005051	catalytic residue [active]
340177005052	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
340177005053	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
340177005054	alanine racemase; Reviewed; Region: alr; PRK00053
340177005055	active site
340177005056	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
340177005057	dimer interface [polypeptide binding]; other site
340177005058	substrate binding site [chemical binding]; other site
340177005059	catalytic residues [active]
340177005060	Lipopolysaccharide-assembly; Region: LptE; cl01125
340177005061	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
340177005062	classical (c) SDRs; Region: SDR_c; cd05233
340177005063	NAD(P) binding site [chemical binding]; other site
340177005064	active site
340177005065	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
340177005066	ribulose bisphosphate carboxylase, type III; Region: rubisco_III; TIGR03326
340177005067	dimer interface [polypeptide binding]; other site
340177005068	catalytic residue [active]
340177005069	metal binding site [ion binding]; metal-binding site
340177005070	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
340177005071	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
340177005072	putative active site; other site
340177005073	catalytic residue [active]
340177005074	short chain dehydrogenase; Validated; Region: PRK08324
340177005075	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
340177005076	active site
340177005077	Zn2+ binding site [ion binding]; other site
340177005078	intersubunit interface [polypeptide binding]; other site
340177005079	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
340177005080	putative NAD(P) binding site [chemical binding]; other site
340177005081	active site
340177005082	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
340177005083	recombination regulator RecX; Reviewed; Region: recX; PRK00117
340177005084	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
340177005085	putative nucleotide binding site [chemical binding]; other site
340177005086	uridine monophosphate binding site [chemical binding]; other site
340177005087	homohexameric interface [polypeptide binding]; other site
340177005088	elongation factor Ts; Provisional; Region: tsf; PRK09377
340177005089	UBA/TS-N domain; Region: UBA; pfam00627
340177005090	Elongation factor TS; Region: EF_TS; pfam00889
340177005091	Elongation factor TS; Region: EF_TS; pfam00889
340177005092	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
340177005093	rRNA interaction site [nucleotide binding]; other site
340177005094	S8 interaction site; other site
340177005095	putative laminin-1 binding site; other site
340177005096	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
340177005097	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
340177005098	23S rRNA interface [nucleotide binding]; other site
340177005099	L3 interface [polypeptide binding]; other site
340177005100	GTP-binding protein Der; Reviewed; Region: PRK00093
340177005101	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
340177005102	G1 box; other site
340177005103	GTP/Mg2+ binding site [chemical binding]; other site
340177005104	Switch I region; other site
340177005105	G2 box; other site
340177005106	Switch II region; other site
340177005107	G3 box; other site
340177005108	G4 box; other site
340177005109	G5 box; other site
340177005110	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
340177005111	G1 box; other site
340177005112	GTP/Mg2+ binding site [chemical binding]; other site
340177005113	Switch I region; other site
340177005114	G2 box; other site
340177005115	G3 box; other site
340177005116	Switch II region; other site
340177005117	G4 box; other site
340177005118	G5 box; other site
340177005119	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
340177005120	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
340177005121	Walker A motif; other site
340177005122	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
340177005123	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
340177005124	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
340177005125	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
340177005126	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
340177005127	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
340177005128	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
340177005129	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
340177005130	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
340177005131	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
340177005132	tetramer interface [polypeptide binding]; other site
340177005133	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177005134	catalytic residue [active]
340177005135	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
340177005136	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
340177005137	dimerization interface [polypeptide binding]; other site
340177005138	active site
340177005139	metal binding site [ion binding]; metal-binding site
340177005140	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
340177005141	dsRNA binding site [nucleotide binding]; other site
340177005142	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
340177005143	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
340177005144	dimer interface [polypeptide binding]; other site
340177005145	active site
340177005146	acyl carrier protein; Provisional; Region: acpP; PRK00982
340177005147	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
340177005148	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
340177005149	NAD(P) binding site [chemical binding]; other site
340177005150	homotetramer interface [polypeptide binding]; other site
340177005151	homodimer interface [polypeptide binding]; other site
340177005152	active site
340177005153	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
340177005154	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
340177005155	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
340177005156	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
340177005157	dimer interface [polypeptide binding]; other site
340177005158	active site
340177005159	CoA binding pocket [chemical binding]; other site
340177005160	putative phosphate acyltransferase; Provisional; Region: PRK05331
340177005161	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
340177005162	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
340177005163	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
340177005164	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
340177005165	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
340177005166	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
340177005167	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
340177005168	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340177005169	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
340177005170	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
340177005171	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
340177005172	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
340177005173	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
340177005174	acyl-activating enzyme (AAE) consensus motif; other site
340177005175	putative AMP binding site [chemical binding]; other site
340177005176	putative active site [active]
340177005177	putative CoA binding site [chemical binding]; other site
340177005178	2-isopropylmalate synthase; Validated; Region: PRK03739
340177005179	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
340177005180	active site
340177005181	catalytic residues [active]
340177005182	metal binding site [ion binding]; metal-binding site
340177005183	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
340177005184	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
340177005185	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
340177005186	intersubunit interface [polypeptide binding]; other site
340177005187	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
340177005188	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
340177005189	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
340177005190	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
340177005191	ABC-ATPase subunit  interface; other site
340177005192	dimer interface [polypeptide binding]; other site
340177005193	putative PBP binding regions; other site
340177005194	Proteolipid membrane potential modulator; Region: Pmp3; cl00431
340177005195	Oxygen tolerance; Region: BatD; pfam13584
340177005196	pyrroline-5-carboxylate reductase; Region: PLN02688
340177005197	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
340177005198	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
340177005199	ResB-like family; Region: ResB; pfam05140
340177005200	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
340177005201	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
340177005202	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
340177005203	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
340177005204	DsbD alpha interface [polypeptide binding]; other site
340177005205	catalytic residues [active]
340177005206	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
340177005207	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
340177005208	acetyl-CoA synthetase; Provisional; Region: PRK00174
340177005209	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
340177005210	active site
340177005211	CoA binding site [chemical binding]; other site
340177005212	acyl-activating enzyme (AAE) consensus motif; other site
340177005213	AMP binding site [chemical binding]; other site
340177005214	acetate binding site [chemical binding]; other site
340177005215	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
340177005216	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
340177005217	HIGH motif; other site
340177005218	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
340177005219	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
340177005220	active site
340177005221	KMSKS motif; other site
340177005222	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
340177005223	tRNA binding surface [nucleotide binding]; other site
340177005224	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
340177005225	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
340177005226	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
340177005227	RNase E interface [polypeptide binding]; other site
340177005228	trimer interface [polypeptide binding]; other site
340177005229	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
340177005230	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
340177005231	RNase E interface [polypeptide binding]; other site
340177005232	trimer interface [polypeptide binding]; other site
340177005233	active site
340177005234	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
340177005235	putative nucleic acid binding region [nucleotide binding]; other site
340177005236	G-X-X-G motif; other site
340177005237	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
340177005238	RNA binding site [nucleotide binding]; other site
340177005239	domain interface; other site
340177005240	Predicted esterase [General function prediction only]; Region: COG0400
340177005241	putative hydrolase; Provisional; Region: PRK11460
340177005242	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
340177005243	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
340177005244	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
340177005245	substrate binding pocket [chemical binding]; other site
340177005246	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
340177005247	B12 binding site [chemical binding]; other site
340177005248	cobalt ligand [ion binding]; other site
340177005249	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
340177005250	HRDC domain; Region: HRDC; pfam00570
340177005251	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
340177005252	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
340177005253	putative active site [active]
340177005254	putative NTP binding site [chemical binding]; other site
340177005255	putative nucleic acid binding site [nucleotide binding]; other site
340177005256	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
340177005257	Uncharacterized conserved protein [Function unknown]; Region: COG1262
340177005258	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
340177005259	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
340177005260	ligand binding site [chemical binding]; other site
340177005261	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173
340177005262	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
340177005263	dimer interface [polypeptide binding]; other site
340177005264	tetramer interface [polypeptide binding]; other site
340177005265	PYR/PP interface [polypeptide binding]; other site
340177005266	TPP binding site [chemical binding]; other site
340177005267	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
340177005268	TPP-binding site; other site
340177005269	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
340177005270	chorismate binding enzyme; Region: Chorismate_bind; cl10555
340177005271	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
340177005272	Tetratricopeptide repeat; Region: TPR_16; pfam13432
340177005273	binding surface
340177005274	TPR motif; other site
340177005275	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177005276	binding surface
340177005277	TPR motif; other site
340177005278	TPR repeat; Region: TPR_11; pfam13414
340177005279	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
340177005280	tandem repeat interface [polypeptide binding]; other site
340177005281	oligomer interface [polypeptide binding]; other site
340177005282	active site residues [active]
340177005283	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
340177005284	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
340177005285	tandem repeat interface [polypeptide binding]; other site
340177005286	oligomer interface [polypeptide binding]; other site
340177005287	active site residues [active]
340177005288	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
340177005289	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
340177005290	Walker A/P-loop; other site
340177005291	ATP binding site [chemical binding]; other site
340177005292	Q-loop/lid; other site
340177005293	ABC transporter signature motif; other site
340177005294	Walker B; other site
340177005295	D-loop; other site
340177005296	H-loop/switch region; other site
340177005297	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
340177005298	Predicted methyltransferases [General function prediction only]; Region: COG0313
340177005299	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
340177005300	putative SAM binding site [chemical binding]; other site
340177005301	putative homodimer interface [polypeptide binding]; other site
340177005302	pantoate--beta-alanine ligase; Region: panC; TIGR00018
340177005303	Pantoate-beta-alanine ligase; Region: PanC; cd00560
340177005304	active site
340177005305	ATP-binding site [chemical binding]; other site
340177005306	pantoate-binding site; other site
340177005307	HXXH motif; other site
340177005308	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
340177005309	AAA domain; Region: AAA_14; pfam13173
340177005310	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
340177005311	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
340177005312	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
340177005313	dimer interface [polypeptide binding]; other site
340177005314	active site
340177005315	metal binding site [ion binding]; metal-binding site
340177005316	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
340177005317	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
340177005318	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
340177005319	dimer interface [polypeptide binding]; other site
340177005320	motif 1; other site
340177005321	active site
340177005322	motif 2; other site
340177005323	motif 3; other site
340177005324	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
340177005325	23S rRNA binding site [nucleotide binding]; other site
340177005326	L21 binding site [polypeptide binding]; other site
340177005327	L13 binding site [polypeptide binding]; other site
340177005328	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
340177005329	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
340177005330	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
340177005331	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
340177005332	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
340177005333	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
340177005334	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
340177005335	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
340177005336	active site
340177005337	dimer interface [polypeptide binding]; other site
340177005338	motif 1; other site
340177005339	motif 2; other site
340177005340	motif 3; other site
340177005341	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
340177005342	anticodon binding site; other site
340177005343	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
340177005344	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
340177005345	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
340177005346	Protein of unknown function (DUF511); Region: DUF511; pfam04373
340177005347	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
340177005348	o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927
340177005349	active site
340177005350	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
340177005351	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
340177005352	substrate binding site [chemical binding]; other site
340177005353	oxyanion hole (OAH) forming residues; other site
340177005354	trimer interface [polypeptide binding]; other site
340177005355	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
340177005356	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
340177005357	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
340177005358	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
340177005359	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
340177005360	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177005361	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
340177005362	potassium uptake protein; Region: kup; TIGR00794
340177005363	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
340177005364	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
340177005365	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
340177005366	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
340177005367	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
340177005368	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
340177005369	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
340177005370	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
340177005371	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
340177005372	NADH(P)-binding; Region: NAD_binding_10; pfam13460
340177005373	NAD(P) binding site [chemical binding]; other site
340177005374	putative active site [active]
340177005375	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
340177005376	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
340177005377	dimer interface [polypeptide binding]; other site
340177005378	PYR/PP interface [polypeptide binding]; other site
340177005379	TPP binding site [chemical binding]; other site
340177005380	substrate binding site [chemical binding]; other site
340177005381	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
340177005382	Domain of unknown function; Region: EKR; pfam10371
340177005383	4Fe-4S binding domain; Region: Fer4_6; pfam12837
340177005384	4Fe-4S binding domain; Region: Fer4; pfam00037
340177005385	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
340177005386	TPP-binding site [chemical binding]; other site
340177005387	dimer interface [polypeptide binding]; other site
340177005388	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
340177005389	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
340177005390	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
340177005391	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
340177005392	lipoyl attachment site [posttranslational modification]; other site
340177005393	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
340177005394	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
340177005395	tetramer interface [polypeptide binding]; other site
340177005396	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177005397	catalytic residue [active]
340177005398	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
340177005399	dihydrodipicolinate synthase; Region: dapA; TIGR00674
340177005400	dimer interface [polypeptide binding]; other site
340177005401	active site
340177005402	catalytic residue [active]
340177005403	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
340177005404	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
340177005405	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
340177005406	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
340177005407	dinuclear metal binding motif [ion binding]; other site
340177005408	Restriction endonuclease NotI; Region: NotI; pfam12183
340177005409	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
340177005410	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
340177005411	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
340177005412	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
340177005413	active site
340177005414	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
340177005415	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
340177005416	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
340177005417	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
340177005418	UbiA prenyltransferase family; Region: UbiA; pfam01040
340177005419	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
340177005420	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
340177005421	RNA/DNA hybrid binding site [nucleotide binding]; other site
340177005422	active site
340177005423	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
340177005424	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
340177005425	Ligand Binding Site [chemical binding]; other site
340177005426	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
340177005427	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
340177005428	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
340177005429	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
340177005430	Walker A/P-loop; other site
340177005431	ATP binding site [chemical binding]; other site
340177005432	Q-loop/lid; other site
340177005433	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
340177005434	ABC transporter signature motif; other site
340177005435	Walker B; other site
340177005436	D-loop; other site
340177005437	H-loop/switch region; other site
340177005438	Methyltransferase domain; Region: Methyltransf_11; pfam08241
340177005439	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
340177005440	Putative addiction module component; Region: Unstab_antitox; pfam09720
340177005441	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
340177005442	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
340177005443	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
340177005444	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
340177005445	NAD(P) binding site [chemical binding]; other site
340177005446	catalytic residues [active]
340177005447	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
340177005448	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
340177005449	putative deacylase active site [active]
340177005450	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
340177005451	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
340177005452	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177005453	Walker A motif; other site
340177005454	ATP binding site [chemical binding]; other site
340177005455	Walker B motif; other site
340177005456	arginine finger; other site
340177005457	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
340177005458	Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643
340177005459	7-cyano-7-deazaguanine reductase; Region: QueF-II; TIGR03139
340177005460	active site
340177005461	Predicted methyltransferase [General function prediction only]; Region: COG3897
340177005462	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340177005463	S-adenosylmethionine binding site [chemical binding]; other site
340177005464	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
340177005465	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
340177005466	active site
340177005467	DNA binding site [nucleotide binding]
340177005468	Int/Topo IB signature motif; other site
340177005469	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
340177005470	30S subunit binding site; other site
340177005471	HPr kinase/phosphorylase; Provisional; Region: PRK05428
340177005472	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
340177005473	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
340177005474	Hpr binding site; other site
340177005475	active site
340177005476	homohexamer subunit interaction site [polypeptide binding]; other site
340177005477	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
340177005478	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
340177005479	peptide binding site [polypeptide binding]; other site
340177005480	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
340177005481	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
340177005482	dimer interface [polypeptide binding]; other site
340177005483	conserved gate region; other site
340177005484	putative PBP binding loops; other site
340177005485	ABC-ATPase subunit interface; other site
340177005486	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
340177005487	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177005488	Walker A motif; other site
340177005489	ATP binding site [chemical binding]; other site
340177005490	Walker B motif; other site
340177005491	arginine finger; other site
340177005492	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
340177005493	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177005494	binding surface
340177005495	TPR motif; other site
340177005496	TPR repeat; Region: TPR_11; pfam13414
340177005497	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177005498	binding surface
340177005499	TPR motif; other site
340177005500	TPR repeat; Region: TPR_11; pfam13414
340177005501	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177005502	binding surface
340177005503	TPR motif; other site
340177005504	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177005505	binding surface
340177005506	TPR motif; other site
340177005507	PIN domain; Region: PIN_3; cl17397
340177005508	Repair protein; Region: Repair_PSII; cl01535
340177005509	AAA domain; Region: AAA_23; pfam13476
340177005510	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
340177005511	AAA domain; Region: AAA_21; pfam13304
340177005512	Walker A/P-loop; other site
340177005513	ATP binding site [chemical binding]; other site
340177005514	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
340177005515	ABC transporter signature motif; other site
340177005516	Walker B; other site
340177005517	D-loop; other site
340177005518	H-loop/switch region; other site
340177005519	Repair protein; Region: Repair_PSII; pfam04536
340177005520	LemA family; Region: LemA; pfam04011
340177005521	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
340177005522	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
340177005523	Zn2+ binding site [ion binding]; other site
340177005524	Mg2+ binding site [ion binding]; other site
340177005525	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
340177005526	synthetase active site [active]
340177005527	NTP binding site [chemical binding]; other site
340177005528	metal binding site [ion binding]; metal-binding site
340177005529	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
340177005530	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
340177005531	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
340177005532	oligomeric interface; other site
340177005533	putative active site [active]
340177005534	homodimer interface [polypeptide binding]; other site
340177005535	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
340177005536	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
340177005537	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
340177005538	homodimer interface [polypeptide binding]; other site
340177005539	substrate-cofactor binding pocket; other site
340177005540	catalytic residue [active]
340177005541	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
340177005542	active site
340177005543	ADP/pyrophosphate binding site [chemical binding]; other site
340177005544	dimerization interface [polypeptide binding]; other site
340177005545	allosteric effector site; other site
340177005546	fructose-1,6-bisphosphate binding site; other site
340177005547	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
340177005548	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
340177005549	FtsX-like permease family; Region: FtsX; pfam02687
340177005550	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
340177005551	homotrimer interaction site [polypeptide binding]; other site
340177005552	zinc binding site [ion binding]; other site
340177005553	CDP-binding sites; other site
340177005554	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
340177005555	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
340177005556	heterodimer interface [polypeptide binding]; other site
340177005557	active site
340177005558	FMN binding site [chemical binding]; other site
340177005559	homodimer interface [polypeptide binding]; other site
340177005560	substrate binding site [chemical binding]; other site
340177005561	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
340177005562	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
340177005563	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
340177005564	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
340177005565	active site
340177005566	metal binding site [ion binding]; metal-binding site
340177005567	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
340177005568	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
340177005569	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
340177005570	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
340177005571	ATP-grasp domain; Region: ATP-grasp_4; cl17255
340177005572	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
340177005573	IMP binding site; other site
340177005574	dimer interface [polypeptide binding]; other site
340177005575	interdomain contacts; other site
340177005576	partial ornithine binding site; other site
340177005577	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
340177005578	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
340177005579	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
340177005580	dimerization interface [polypeptide binding]; other site
340177005581	active site
340177005582	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
340177005583	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
340177005584	dimer interface [polypeptide binding]; other site
340177005585	active site
340177005586	glycine-pyridoxal phosphate binding site [chemical binding]; other site
340177005587	folate binding site [chemical binding]; other site
340177005588	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
340177005589	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
340177005590	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
340177005591	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
340177005592	Uncharacterized conserved protein [Function unknown]; Region: COG2968
340177005593	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
340177005594	Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642
340177005595	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
340177005596	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
340177005597	putative active site [active]
340177005598	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
340177005599	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
340177005600	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
340177005601	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
340177005602	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
340177005603	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340177005604	non-specific DNA binding site [nucleotide binding]; other site
340177005605	salt bridge; other site
340177005606	sequence-specific DNA binding site [nucleotide binding]; other site
340177005607	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
340177005608	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
340177005609	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
340177005610	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
340177005611	MgtE intracellular N domain; Region: MgtE_N; smart00924
340177005612	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
340177005613	Divalent cation transporter; Region: MgtE; pfam01769
340177005614	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
340177005615	active site
340177005616	DNA binding site [nucleotide binding]
340177005617	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
340177005618	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
340177005619	P-loop; other site
340177005620	Magnesium ion binding site [ion binding]; other site
340177005621	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
340177005622	Magnesium ion binding site [ion binding]; other site
340177005623	ParB-like nuclease domain; Region: ParB; smart00470
340177005624	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
340177005625	dihydrodipicolinate reductase; Provisional; Region: PRK00048
340177005626	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
340177005627	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
340177005628	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
340177005629	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177005630	FeS/SAM binding site; other site
340177005631	HemN C-terminal domain; Region: HemN_C; pfam06969
340177005632	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
340177005633	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
340177005634	active site
340177005635	motif I; other site
340177005636	motif II; other site
340177005637	glycogen synthase; Provisional; Region: PRK14098
340177005638	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
340177005639	ADP-binding pocket [chemical binding]; other site
340177005640	homodimer interface [polypeptide binding]; other site
340177005641	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177005642	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
340177005643	V4R domain; Region: V4R; cl15268
340177005644	Predicted transcriptional regulator [Transcription]; Region: COG2944
340177005645	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340177005646	non-specific DNA binding site [nucleotide binding]; other site
340177005647	salt bridge; other site
340177005648	sequence-specific DNA binding site [nucleotide binding]; other site
340177005649	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
340177005650	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
340177005651	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
340177005652	P-loop; other site
340177005653	light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910
340177005654	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
340177005655	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
340177005656	light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842
340177005657	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
340177005658	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
340177005659	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
340177005660	GDP-binding site [chemical binding]; other site
340177005661	ACT binding site; other site
340177005662	IMP binding site; other site
340177005663	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
340177005664	G1 box; other site
340177005665	GTP/Mg2+ binding site [chemical binding]; other site
340177005666	Switch I region; other site
340177005667	G2 box; other site
340177005668	G3 box; other site
340177005669	Switch II region; other site
340177005670	G4 box; other site
340177005671	G5 box; other site
340177005672	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
340177005673	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
340177005674	active site
340177005675	HIGH motif; other site
340177005676	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
340177005677	KMSKS motif; other site
340177005678	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
340177005679	tRNA binding surface [nucleotide binding]; other site
340177005680	anticodon binding site; other site
340177005681	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
340177005682	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
340177005683	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
340177005684	Substrate binding site; other site
340177005685	Cupin domain; Region: Cupin_2; cl17218
340177005686	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
340177005687	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
340177005688	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
340177005689	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
340177005690	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
340177005691	alphaNTD homodimer interface [polypeptide binding]; other site
340177005692	alphaNTD - beta interaction site [polypeptide binding]; other site
340177005693	alphaNTD - beta' interaction site [polypeptide binding]; other site
340177005694	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
340177005695	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
340177005696	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
340177005697	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
340177005698	RNA binding surface [nucleotide binding]; other site
340177005699	30S ribosomal protein S11; Validated; Region: PRK05309
340177005700	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
340177005701	30S ribosomal protein S13; Region: bact_S13; TIGR03631
340177005702	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
340177005703	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
340177005704	rRNA binding site [nucleotide binding]; other site
340177005705	predicted 30S ribosome binding site; other site
340177005706	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
340177005707	active site
340177005708	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
340177005709	SecY translocase; Region: SecY; pfam00344
340177005710	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
340177005711	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
340177005712	23S rRNA binding site [nucleotide binding]; other site
340177005713	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
340177005714	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
340177005715	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
340177005716	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
340177005717	5S rRNA interface [nucleotide binding]; other site
340177005718	23S rRNA interface [nucleotide binding]; other site
340177005719	L5 interface [polypeptide binding]; other site
340177005720	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
340177005721	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
340177005722	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
340177005723	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
340177005724	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
340177005725	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
340177005726	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
340177005727	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
340177005728	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
340177005729	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
340177005730	RNA binding site [nucleotide binding]; other site
340177005731	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
340177005732	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
340177005733	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
340177005734	putative translocon interaction site; other site
340177005735	23S rRNA interface [nucleotide binding]; other site
340177005736	signal recognition particle (SRP54) interaction site; other site
340177005737	L23 interface [polypeptide binding]; other site
340177005738	trigger factor interaction site; other site
340177005739	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
340177005740	23S rRNA interface [nucleotide binding]; other site
340177005741	5S rRNA interface [nucleotide binding]; other site
340177005742	putative antibiotic binding site [chemical binding]; other site
340177005743	L25 interface [polypeptide binding]; other site
340177005744	L27 interface [polypeptide binding]; other site
340177005745	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
340177005746	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
340177005747	G-X-X-G motif; other site
340177005748	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
340177005749	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
340177005750	putative translocon binding site; other site
340177005751	protein-rRNA interface [nucleotide binding]; other site
340177005752	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
340177005753	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
340177005754	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
340177005755	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
340177005756	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
340177005757	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
340177005758	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
340177005759	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
340177005760	elongation factor Tu; Reviewed; Region: PRK00049
340177005761	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
340177005762	G1 box; other site
340177005763	GEF interaction site [polypeptide binding]; other site
340177005764	GTP/Mg2+ binding site [chemical binding]; other site
340177005765	Switch I region; other site
340177005766	G2 box; other site
340177005767	G3 box; other site
340177005768	Switch II region; other site
340177005769	G4 box; other site
340177005770	G5 box; other site
340177005771	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
340177005772	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
340177005773	Antibiotic Binding Site [chemical binding]; other site
340177005774	elongation factor G; Reviewed; Region: PRK00007
340177005775	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
340177005776	G1 box; other site
340177005777	putative GEF interaction site [polypeptide binding]; other site
340177005778	GTP/Mg2+ binding site [chemical binding]; other site
340177005779	Switch I region; other site
340177005780	G2 box; other site
340177005781	G3 box; other site
340177005782	Switch II region; other site
340177005783	G4 box; other site
340177005784	G5 box; other site
340177005785	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
340177005786	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
340177005787	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
340177005788	30S ribosomal protein S7; Validated; Region: PRK05302
340177005789	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
340177005790	S17 interaction site [polypeptide binding]; other site
340177005791	S8 interaction site; other site
340177005792	16S rRNA interaction site [nucleotide binding]; other site
340177005793	streptomycin interaction site [chemical binding]; other site
340177005794	23S rRNA interaction site [nucleotide binding]; other site
340177005795	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
340177005796	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
340177005797	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
340177005798	non-specific DNA binding site [nucleotide binding]; other site
340177005799	salt bridge; other site
340177005800	sequence-specific DNA binding site [nucleotide binding]; other site
340177005801	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
340177005802	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
340177005803	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340177005804	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
340177005805	putative homodimer interface [polypeptide binding]; other site
340177005806	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
340177005807	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
340177005808	Methyltransferase domain; Region: Methyltransf_23; pfam13489
340177005809	Virulence protein [General function prediction only]; Region: COG3943
340177005810	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
340177005811	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
340177005812	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
340177005813	Probable Catalytic site; other site
340177005814	metal-binding site
340177005815	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
340177005816	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
340177005817	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
340177005818	dimerization domain swap beta strand [polypeptide binding]; other site
340177005819	regulatory protein interface [polypeptide binding]; other site
340177005820	active site
340177005821	regulatory phosphorylation site [posttranslational modification]; other site
340177005822	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
340177005823	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
340177005824	Coenzyme A binding pocket [chemical binding]; other site
340177005825	GTPase CgtA; Reviewed; Region: obgE; PRK12299
340177005826	GTP1/OBG; Region: GTP1_OBG; pfam01018
340177005827	Obg GTPase; Region: Obg; cd01898
340177005828	G1 box; other site
340177005829	GTP/Mg2+ binding site [chemical binding]; other site
340177005830	Switch I region; other site
340177005831	G2 box; other site
340177005832	G3 box; other site
340177005833	Switch II region; other site
340177005834	G4 box; other site
340177005835	G5 box; other site
340177005836	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
340177005837	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
340177005838	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
340177005839	GatB domain; Region: GatB_Yqey; smart00845
340177005840	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
340177005841	AAA ATPase domain; Region: AAA_16; pfam13191
340177005842	Tetratricopeptide repeat; Region: TPR_12; pfam13424
340177005843	Clp amino terminal domain; Region: Clp_N; pfam02861
340177005844	Clp amino terminal domain; Region: Clp_N; pfam02861
340177005845	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177005846	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
340177005847	Walker A motif; other site
340177005848	ATP binding site [chemical binding]; other site
340177005849	Walker B motif; other site
340177005850	arginine finger; other site
340177005851	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
340177005852	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
340177005853	hexamer interface [polypeptide binding]; other site
340177005854	ligand binding site [chemical binding]; other site
340177005855	putative active site [active]
340177005856	NAD(P) binding site [chemical binding]; other site
340177005857	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
340177005858	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
340177005859	catalytic loop [active]
340177005860	iron binding site [ion binding]; other site
340177005861	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
340177005862	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
340177005863	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
340177005864	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
340177005865	ATP binding site [chemical binding]; other site
340177005866	putative Mg++ binding site [ion binding]; other site
340177005867	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
340177005868	nucleotide binding region [chemical binding]; other site
340177005869	ATP-binding site [chemical binding]; other site
340177005870	TRCF domain; Region: TRCF; pfam03461
340177005871	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
340177005872	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
340177005873	Walker A/P-loop; other site
340177005874	ATP binding site [chemical binding]; other site
340177005875	Q-loop/lid; other site
340177005876	ABC transporter signature motif; other site
340177005877	Walker B; other site
340177005878	D-loop; other site
340177005879	H-loop/switch region; other site
340177005880	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
340177005881	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
340177005882	Divergent AAA domain; Region: AAA_4; pfam04326
340177005883	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
340177005884	Aerotolerance regulator N-terminal; Region: BatA; cl06567
340177005885	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
340177005886	metal ion-dependent adhesion site (MIDAS); other site
340177005887	von Willebrand factor type A domain; Region: VWA_2; pfam13519
340177005888	metal ion-dependent adhesion site (MIDAS); other site
340177005889	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
340177005890	carotene isomerase; Region: carot_isom; TIGR02730
340177005891	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
340177005892	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
340177005893	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
340177005894	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
340177005895	DNA binding residues [nucleotide binding]
340177005896	Putative zinc-finger; Region: zf-HC2; pfam13490
340177005897	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
340177005898	dimerization interface [polypeptide binding]; other site
340177005899	putative DNA binding site [nucleotide binding]; other site
340177005900	putative Zn2+ binding site [ion binding]; other site
340177005901	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
340177005902	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
340177005903	putative dimer interface [polypeptide binding]; other site
340177005904	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
340177005905	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
340177005906	nucleotide binding site [chemical binding]; other site
340177005907	NEF interaction site [polypeptide binding]; other site
340177005908	SBD interface [polypeptide binding]; other site
340177005909	Photosystem P840 reaction centre protein PscD; Region: RC-P840_PscD; pfam10657
340177005910	Nidogen-like; Region: NIDO; cl02648
340177005911	Family description; Region: VCBS; pfam13517
340177005912	Family description; Region: VCBS; pfam13517
340177005913	Family description; Region: VCBS; pfam13517
340177005914	Family description; Region: VCBS; pfam13517
340177005915	Family description; Region: VCBS; pfam13517
340177005916	Bacterial Ig-like domain; Region: Big_5; pfam13205
340177005917	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
340177005918	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
340177005919	active site
340177005920	catalytic residues [active]
340177005921	metal binding site [ion binding]; metal-binding site
340177005922	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
340177005923	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
340177005924	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
340177005925	substrate binding site [chemical binding]; other site
340177005926	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
340177005927	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
340177005928	substrate binding site [chemical binding]; other site
340177005929	ligand binding site [chemical binding]; other site
340177005930	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
340177005931	tartrate dehydrogenase; Region: TTC; TIGR02089
340177005932	ketol-acid reductoisomerase; Provisional; Region: PRK05479
340177005933	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
340177005934	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
340177005935	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
340177005936	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
340177005937	putative valine binding site [chemical binding]; other site
340177005938	dimer interface [polypeptide binding]; other site
340177005939	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
340177005940	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
340177005941	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
340177005942	PYR/PP interface [polypeptide binding]; other site
340177005943	dimer interface [polypeptide binding]; other site
340177005944	TPP binding site [chemical binding]; other site
340177005945	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
340177005946	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
340177005947	TPP-binding site [chemical binding]; other site
340177005948	dimer interface [polypeptide binding]; other site
340177005949	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
340177005950	6-phosphogluconate dehydratase; Region: edd; TIGR01196
340177005951	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
340177005952	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
340177005953	TolR protein; Region: tolR; TIGR02801
340177005954	TonB C terminal; Region: TonB_2; pfam13103
340177005955	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
340177005956	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
340177005957	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
340177005958	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
340177005959	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
340177005960	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
340177005961	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
340177005962	ligand binding site [chemical binding]; other site
340177005963	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
340177005964	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177005965	binding surface
340177005966	TPR motif; other site
340177005967	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
340177005968	Transposase; Region: DDE_Tnp_ISL3; pfam01610
340177005969	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
340177005970	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
340177005971	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
340177005972	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
340177005973	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
340177005974	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
340177005975	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
340177005976	Cytochrome c [Energy production and conversion]; Region: COG3258
340177005977	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
340177005978	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
340177005979	active site
340177005980	metal binding site [ion binding]; metal-binding site
340177005981	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
340177005982	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
340177005983	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
340177005984	catalytic residues [active]
340177005985	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
340177005986	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
340177005987	G1 box; other site
340177005988	GTP/Mg2+ binding site [chemical binding]; other site
340177005989	Switch I region; other site
340177005990	G2 box; other site
340177005991	G3 box; other site
340177005992	Switch II region; other site
340177005993	G4 box; other site
340177005994	G5 box; other site
340177005995	Nucleoside recognition; Region: Gate; pfam07670
340177005996	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
340177005997	Nucleoside recognition; Region: Gate; pfam07670
340177005998	FeoA domain; Region: FeoA; pfam04023
340177005999	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
340177006000	nucleotide binding site/active site [active]
340177006001	HIT family signature motif; other site
340177006002	catalytic residue [active]
340177006003	Domain of unknown function DUF21; Region: DUF21; pfam01595
340177006004	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
340177006005	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
340177006006	Transporter associated domain; Region: CorC_HlyC; smart01091
340177006007	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
340177006008	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
340177006009	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
340177006010	L-aspartate oxidase; Provisional; Region: PRK06175
340177006011	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
340177006012	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
340177006013	proximal heme binding site [chemical binding]; other site
340177006014	putative dimer interface [polypeptide binding]; other site
340177006015	putative Iron-sulfur protein interface [polypeptide binding]; other site
340177006016	distal heme binding site [chemical binding]; other site
340177006017	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
340177006018	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
340177006019	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
340177006020	Sel1-like repeats; Region: SEL1; smart00671
340177006021	Sel1-like repeats; Region: SEL1; smart00671
340177006022	Sel1-like repeats; Region: SEL1; smart00671
340177006023	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
340177006024	Sel1-like repeats; Region: SEL1; smart00671
340177006025	Sel1-like repeats; Region: SEL1; smart00671
340177006026	Sel1-like repeats; Region: SEL1; smart00671
340177006027	Sel1-like repeats; Region: SEL1; smart00671
340177006028	Sel1-like repeats; Region: SEL1; smart00671
340177006029	Sel1-like repeats; Region: SEL1; smart00671
340177006030	Sel1-like repeats; Region: SEL1; smart00671
340177006031	Esterase/lipase [General function prediction only]; Region: COG1647
340177006032	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
340177006033	catalytic site [active]
340177006034	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
340177006035	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
340177006036	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
340177006037	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
340177006038	FeS/SAM binding site; other site
340177006039	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
340177006040	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
340177006041	active site
340177006042	SAM binding site [chemical binding]; other site
340177006043	homodimer interface [polypeptide binding]; other site
340177006044	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
340177006045	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
340177006046	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
340177006047	4Fe-4S binding domain; Region: Fer4; cl02805
340177006048	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
340177006049	Cysteine-rich domain; Region: CCG; pfam02754
340177006050	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
340177006051	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
340177006052	sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011
340177006053	sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010
340177006054	sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012
340177006055	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
340177006056	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
340177006057	sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066
340177006058	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
340177006059	sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064
340177006060	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
340177006061	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
340177006062	sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342
340177006063	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
340177006064	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
340177006065	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
340177006066	catalytic triad [active]
340177006067	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
340177006068	CPxP  motif; other site
340177006069	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
340177006070	active site residue [active]
340177006071	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
340177006072	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
340177006073	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
340177006074	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
340177006075	molybdopterin cofactor binding site; other site
340177006076	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
340177006077	putative molybdopterin cofactor binding site; other site
340177006078	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
340177006079	4Fe-4S binding domain; Region: Fer4; pfam00037
340177006080	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
340177006081	Transposase IS200 like; Region: Y1_Tnp; pfam01797
340177006082	AAA domain; Region: AAA_13; pfam13166
340177006083	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
340177006084	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
340177006085	inhibitor-cofactor binding pocket; inhibition site
340177006086	pyridoxal 5'-phosphate binding site [chemical binding]; other site
340177006087	catalytic residue [active]
340177006088	Recombination protein O N terminal; Region: RecO_N; pfam11967
340177006089	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
340177006090	Recombination protein O C terminal; Region: RecO_C; pfam02565
340177006091	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
340177006092	OstA-like protein; Region: OstA_2; pfam13100
340177006093	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
340177006094	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
340177006095	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177006096	Walker A motif; other site
340177006097	ATP binding site [chemical binding]; other site
340177006098	Walker B motif; other site
340177006099	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
340177006100	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
340177006101	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
340177006102	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
340177006103	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
340177006104	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
340177006105	homodimer interface [polypeptide binding]; other site
340177006106	metal binding site [ion binding]; metal-binding site
340177006107	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
340177006108	homodimer interface [polypeptide binding]; other site
340177006109	active site
340177006110	putative chemical substrate binding site [chemical binding]; other site
340177006111	metal binding site [ion binding]; metal-binding site
340177006112	Rubrerythrin [Energy production and conversion]; Region: COG1592
340177006113	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
340177006114	binuclear metal center [ion binding]; other site
340177006115	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
340177006116	iron binding site [ion binding]; other site
340177006117	DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052
340177006118	Ferritin-like domain; Region: Ferritin; pfam00210
340177006119	diiron binding motif [ion binding]; other site
340177006120	peroxiredoxin; Provisional; Region: PRK13189
340177006121	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
340177006122	dimer interface [polypeptide binding]; other site
340177006123	decamer (pentamer of dimers) interface [polypeptide binding]; other site
340177006124	catalytic triad [active]
340177006125	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
340177006126	Transposase; Region: DDE_Tnp_ISL3; pfam01610
340177006127	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
340177006128	metal binding site 2 [ion binding]; metal-binding site
340177006129	putative DNA binding helix; other site
340177006130	metal binding site 1 [ion binding]; metal-binding site
340177006131	dimer interface [polypeptide binding]; other site
340177006132	structural Zn2+ binding site [ion binding]; other site
340177006133	trehalose synthase; Region: treS_nterm; TIGR02456
340177006134	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
340177006135	active site
340177006136	catalytic site [active]
340177006137	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
340177006138	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
340177006139	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
340177006140	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
340177006141	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
340177006142	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
340177006143	active site
340177006144	homodimer interface [polypeptide binding]; other site
340177006145	catalytic site [active]
340177006146	acceptor binding site [chemical binding]; other site
340177006147	LabA_like proteins; Region: LabA_like; cd06167
340177006148	putative metal binding site [ion binding]; other site
340177006149	Uncharacterized conserved protein [Function unknown]; Region: COG1432
340177006150	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
340177006151	DNA-binding site [nucleotide binding]; DNA binding site
340177006152	RNA-binding motif; other site
340177006153	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
340177006154	Glycoprotease family; Region: Peptidase_M22; pfam00814
340177006155	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
340177006156	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
340177006157	Uncharacterized conserved protein [Function unknown]; Region: COG4198
340177006158	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
340177006159	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
340177006160	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
340177006161	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
340177006162	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
340177006163	trimer interface [polypeptide binding]; other site
340177006164	active site
340177006165	substrate binding site [chemical binding]; other site
340177006166	CoA binding site [chemical binding]; other site
340177006167	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
340177006168	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
340177006169	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
340177006170	protein binding site [polypeptide binding]; other site
340177006171	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
340177006172	Catalytic dyad [active]
340177006173	hypothetical protein; Reviewed; Region: PRK12497
340177006174	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
340177006175	RNA/DNA hybrid binding site [nucleotide binding]; other site
340177006176	active site
340177006177	Putative addiction module component; Region: Unstab_antitox; pfam09720
340177006178	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
340177006179	ScpA/B protein; Region: ScpA_ScpB; cl00598
340177006180	TPR repeat; Region: TPR_11; pfam13414
340177006181	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177006182	binding surface
340177006183	TPR motif; other site
340177006184	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
340177006185	TPR repeat; Region: TPR_11; pfam13414
340177006186	binding surface
340177006187	TPR motif; other site
340177006188	Nitrogen regulatory protein P-II; Region: P-II; smart00938
340177006189	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
340177006190	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
340177006191	GAF domain; Region: GAF_3; pfam13492
340177006192	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
340177006193	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
340177006194	Walker A motif; other site
340177006195	ATP binding site [chemical binding]; other site
340177006196	Walker B motif; other site
340177006197	arginine finger; other site
340177006198	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
340177006199	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
340177006200	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
340177006201	metal binding site 2 [ion binding]; metal-binding site
340177006202	putative DNA binding helix; other site
340177006203	metal binding site 1 [ion binding]; metal-binding site
340177006204	dimer interface [polypeptide binding]; other site
340177006205	structural Zn2+ binding site [ion binding]; other site
340177006206	Fic family protein [Function unknown]; Region: COG3177
340177006207	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
340177006208	Fic/DOC family; Region: Fic; pfam02661
340177006209	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
340177006210	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
340177006211	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
340177006212	Cytochrome c; Region: Cytochrom_C; cl11414
340177006213	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
340177006214	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
340177006215	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
340177006216	DNA polymerase elongation subunit (family B) [DNA replication, recombination, and repair]; Region: PolB; COG0417
340177006217	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785
340177006218	active site
340177006219	catalytic site [active]
340177006220	substrate binding site [chemical binding]; other site
340177006221	DNA polymerase type-II B subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II_B; cd05538
340177006222	active site
340177006223	metal-binding site
340177006224	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
340177006225	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
340177006226	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
340177006227	Protein of unknown function (DUF721); Region: DUF721; pfam05258
340177006228	H+ Antiporter protein; Region: 2A0121; TIGR00900
340177006229	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
340177006230	putative substrate translocation pore; other site
340177006231	Dodecin; Region: Dodecin; pfam07311
340177006232	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
340177006233	active site
340177006234	substrate-binding site [chemical binding]; other site
340177006235	metal-binding site [ion binding]
340177006236	GTP binding site [chemical binding]; other site
340177006237	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
340177006238	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
340177006239	catalytic residues [active]
340177006240	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
340177006241	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
340177006242	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
340177006243	alpha subunit interaction interface [polypeptide binding]; other site
340177006244	Walker A motif; other site
340177006245	ATP binding site [chemical binding]; other site
340177006246	Walker B motif; other site
340177006247	inhibitor binding site; inhibition site
340177006248	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
340177006249	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
340177006250	gamma subunit interface [polypeptide binding]; other site
340177006251	epsilon subunit interface [polypeptide binding]; other site
340177006252	LBP interface [polypeptide binding]; other site
340177006253	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
340177006254	dimer interface [polypeptide binding]; other site
340177006255	catalytic triad [active]
340177006256	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
340177006257	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
340177006258	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
340177006259	NAD(P) binding site [chemical binding]; other site
340177006260	putative active site [active]
340177006261	exopolyphosphatase; Region: exo_poly_only; TIGR03706
340177006262	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
340177006263	LabA_like proteins; Region: LabA_like; cd06167
340177006264	putative metal binding site [ion binding]; other site
340177006265	Uncharacterized conserved protein [Function unknown]; Region: COG1432
340177006266	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
340177006267	Methyltransferase domain; Region: Methyltransf_18; pfam12847
340177006268	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
340177006269	NlpC/P60 family; Region: NLPC_P60; pfam00877
340177006270	aspartate kinase III; Validated; Region: PRK09084
340177006271	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
340177006272	nucleotide binding site [chemical binding]; other site
340177006273	substrate binding site [chemical binding]; other site
340177006274	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
340177006275	dimer interface [polypeptide binding]; other site
340177006276	allosteric regulatory binding pocket; other site
340177006277	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
340177006278	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
340177006279	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
340177006280	dimerization interface [polypeptide binding]; other site
340177006281	putative ATP binding site [chemical binding]; other site
340177006282	membrane protein; Provisional; Region: PRK14410
340177006283	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
340177006284	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
340177006285	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
340177006286	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
340177006287	catalytic core [active]
340177006288	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
340177006289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
340177006290	S-adenosylmethionine binding site [chemical binding]; other site
340177006291	PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395
340177006292	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
340177006293	active site
340177006294	membrane protein insertase; Provisional; Region: PRK01318
340177006295	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
340177006296	Haemolytic domain; Region: Haemolytic; pfam01809
340177006297	ribonuclease P; Reviewed; Region: rnpA; PRK01903
340177006298	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399