-- dump date 20140619_040538 -- class Genbank::misc_feature -- table misc_feature_note -- id note 182082000001 Uncharacterized conserved protein [Function unknown]; Region: COG2155 182082000002 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 182082000003 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 182082000004 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 182082000005 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 182082000006 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 182082000007 GatB domain; Region: GatB_Yqey; pfam02637 182082000008 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082000009 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082000010 IncA protein; Region: IncA; pfam04156 182082000011 IncA protein; Region: IncA; pfam04156 182082000012 IncA protein; Region: IncA; pfam04156 182082000013 Domain of unknown function (DUF1978); Region: DUF1978; pfam09321 182082000014 IncA protein; Region: IncA; pfam04156 182082000015 Domain of unknown function (DUF1978); Region: DUF1978; pfam09321 182082000016 Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253 182082000017 IncA protein; Region: IncA; pfam04156 182082000018 IncA protein; Region: IncA; pfam04156 182082000019 Domain of unknown function (DUF1978); Region: DUF1978; pfam09321 182082000020 IncA protein; Region: IncA; pfam04156 182082000021 Domain of unknown function (DUF1978); Region: DUF1978; pfam09321 182082000022 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 182082000023 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082000024 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082000025 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082000026 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082000027 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082000028 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082000029 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082000030 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082000031 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082000032 Autotransporter beta-domain; Region: Autotransporter; smart00869 182082000033 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 182082000034 Maf-like protein; Region: Maf; pfam02545 182082000035 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 182082000036 active site 182082000037 dimer interface [polypeptide binding]; other site 182082000038 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 182082000039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 182082000040 Walker A/P-loop; other site 182082000041 ATP binding site [chemical binding]; other site 182082000042 Q-loop/lid; other site 182082000043 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 182082000044 ABC transporter; Region: ABC_tran_2; pfam12848 182082000045 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 182082000046 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 182082000047 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 182082000048 active site 182082000049 Int/Topo IB signature motif; other site 182082000050 ribonuclease Z; Region: RNase_Z; TIGR02651 182082000051 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 182082000052 Found in ATP-dependent protease La (LON); Region: LON; smart00464 182082000053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 182082000054 Walker A motif; other site 182082000055 ATP binding site [chemical binding]; other site 182082000056 Walker B motif; other site 182082000057 arginine finger; other site 182082000058 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 182082000059 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 182082000060 Glycoprotease family; Region: Peptidase_M22; pfam00814 182082000061 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 182082000062 chaperone protein DnaJ; Provisional; Region: PRK14284 182082000063 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 182082000064 HSP70 interaction site [polypeptide binding]; other site 182082000065 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 182082000066 Zn binding sites [ion binding]; other site 182082000067 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 182082000068 dimer interface [polypeptide binding]; other site 182082000069 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 182082000070 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 182082000071 tetramer interface [polypeptide binding]; other site 182082000072 TPP-binding site [chemical binding]; other site 182082000073 heterodimer interface [polypeptide binding]; other site 182082000074 phosphorylation loop region [posttranslational modification] 182082000075 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 182082000076 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 182082000077 alpha subunit interface [polypeptide binding]; other site 182082000078 TPP binding site [chemical binding]; other site 182082000079 heterodimer interface [polypeptide binding]; other site 182082000080 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 182082000081 Appr-1"-p processing enzyme; Region: A1pp; smart00506 182082000082 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 182082000083 Competence protein; Region: Competence; pfam03772 182082000084 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 182082000085 dimerization domain swap beta strand [polypeptide binding]; other site 182082000086 regulatory protein interface [polypeptide binding]; other site 182082000087 active site 182082000088 regulatory phosphorylation site [posttranslational modification]; other site 182082000089 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 182082000090 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 182082000091 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 182082000092 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 182082000093 hypothetical protein; Validated; Region: PRK00153 182082000094 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 182082000095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 182082000096 Walker A motif; other site 182082000097 ATP binding site [chemical binding]; other site 182082000098 Walker B motif; other site 182082000099 arginine finger; other site 182082000100 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 182082000101 IncA protein; Region: IncA; pfam04156 182082000102 Domain of unknown function (DUF1978); Region: DUF1978; pfam09321 182082000103 transferase, transferring glycosyl groups; Region: PLN02939 182082000104 IncA protein; Region: IncA; pfam04156 182082000105 Domain of unknown function (DUF1978); Region: DUF1978; pfam09321 182082000106 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 182082000107 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 182082000108 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 182082000109 Zn2+ binding site [ion binding]; other site 182082000110 Mg2+ binding site [ion binding]; other site 182082000111 porphobilinogen deaminase; Provisional; Region: PRK01066 182082000112 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 182082000113 domain interfaces; other site 182082000114 active site 182082000115 DNA repair protein RadA; Provisional; Region: PRK11823 182082000116 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 182082000117 Walker A motif/ATP binding site; other site 182082000118 ATP binding site [chemical binding]; other site 182082000119 Walker B motif; other site 182082000120 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 182082000121 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 182082000122 dimerization interface [polypeptide binding]; other site 182082000123 active site 182082000124 metal binding site [ion binding]; metal-binding site 182082000125 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 182082000126 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 182082000127 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 182082000128 active site 182082000129 substrate binding site [chemical binding]; other site 182082000130 metal binding site [ion binding]; metal-binding site 182082000131 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 182082000132 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 182082000133 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 182082000134 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 182082000135 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 182082000136 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 182082000137 trimer interface [polypeptide binding]; other site 182082000138 active site 182082000139 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 182082000140 active site 182082000141 phosphorylation site [posttranslational modification] 182082000142 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 182082000143 DNA binding residues [nucleotide binding] 182082000144 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 182082000145 active site 182082000146 phosphorylation site [posttranslational modification] 182082000147 IncA protein; Region: IncA; pfam04156 182082000148 Protein of unknown function (DUF687); Region: DUF687; pfam05095 182082000149 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 182082000150 Protein of unknown function (DUF687); Region: DUF687; pfam05095 182082000151 Fe-S metabolism associated domain; Region: SufE; pfam02657 182082000152 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 182082000153 rRNA binding site [nucleotide binding]; other site 182082000154 predicted 30S ribosome binding site; other site 182082000155 elongation factor Tu; Reviewed; Region: PRK12735 182082000156 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 182082000157 G1 box; other site 182082000158 GEF interaction site [polypeptide binding]; other site 182082000159 GTP/Mg2+ binding site [chemical binding]; other site 182082000160 Switch I region; other site 182082000161 G2 box; other site 182082000162 G3 box; other site 182082000163 Switch II region; other site 182082000164 G4 box; other site 182082000165 G5 box; other site 182082000166 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 182082000167 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 182082000168 Antibiotic Binding Site [chemical binding]; other site 182082000169 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 182082000170 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 182082000171 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 182082000172 putative homodimer interface [polypeptide binding]; other site 182082000173 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 182082000174 heterodimer interface [polypeptide binding]; other site 182082000175 homodimer interface [polypeptide binding]; other site 182082000176 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 182082000177 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 182082000178 putative thiostrepton binding site; other site 182082000179 23S rRNA interface [nucleotide binding]; other site 182082000180 L7/L12 interface [polypeptide binding]; other site 182082000181 L25 interface [polypeptide binding]; other site 182082000182 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 182082000183 mRNA/rRNA interface [nucleotide binding]; other site 182082000184 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 182082000185 23S rRNA interface [nucleotide binding]; other site 182082000186 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 182082000187 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 182082000188 L11 interface [polypeptide binding]; other site 182082000189 putative EF-Tu interaction site [polypeptide binding]; other site 182082000190 putative EF-G interaction site [polypeptide binding]; other site 182082000191 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 182082000192 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 182082000193 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 182082000194 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 182082000195 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 182082000196 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 182082000197 RPB3 interaction site [polypeptide binding]; other site 182082000198 RPB1 interaction site [polypeptide binding]; other site 182082000199 RPB11 interaction site [polypeptide binding]; other site 182082000200 RPB10 interaction site [polypeptide binding]; other site 182082000201 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 182082000202 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 182082000203 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 182082000204 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 182082000205 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 182082000206 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 182082000207 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 182082000208 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 182082000209 DNA binding site [nucleotide binding] 182082000210 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 182082000211 transaldolase-like protein; Provisional; Region: PTZ00411 182082000212 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 182082000213 active site 182082000214 dimer interface [polypeptide binding]; other site 182082000215 catalytic residue [active] 182082000216 V-type ATP synthase subunit E; Provisional; Region: PRK01005 182082000217 V-type ATP synthase subunit E; Provisional; Region: PRK01558 182082000218 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 182082000219 V-type ATP synthase subunit A; Provisional; Region: PRK04192 182082000220 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 182082000221 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 182082000222 Walker A motif/ATP binding site; other site 182082000223 Walker B motif; other site 182082000224 V-type ATP synthase subunit B; Provisional; Region: PRK02118 182082000225 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 182082000226 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 182082000227 Walker A motif homologous position; other site 182082000228 Walker B motif; other site 182082000229 V-type ATP synthase subunit D; Provisional; Region: PRK02195 182082000230 Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269 182082000231 V-type ATP synthase subunit K; Provisional; Region: PRK09621 182082000232 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 182082000233 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 182082000234 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 182082000235 HIGH motif; other site 182082000236 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 182082000237 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 182082000238 active site 182082000239 KMSKS motif; other site 182082000240 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 182082000241 tRNA binding surface [nucleotide binding]; other site 182082000242 anticodon binding site; other site 182082000243 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 182082000244 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 182082000245 Catalytic domain of Protein Kinases; Region: PKc; cd00180 182082000246 active site 182082000247 ATP binding site [chemical binding]; other site 182082000248 substrate binding site [chemical binding]; other site 182082000249 activation loop (A-loop); other site 182082000250 excinuclease ABC subunit A; Provisional; Region: PRK00635 182082000251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 182082000252 Walker A/P-loop; other site 182082000253 ATP binding site [chemical binding]; other site 182082000254 Q-loop/lid; other site 182082000255 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 182082000256 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 182082000257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 182082000258 Walker A/P-loop; other site 182082000259 ATP binding site [chemical binding]; other site 182082000260 Q-loop/lid; other site 182082000261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 182082000262 Q-loop/lid; other site 182082000263 ABC transporter signature motif; other site 182082000264 Walker B; other site 182082000265 D-loop; other site 182082000266 H-loop/switch region; other site 182082000267 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 182082000268 Walker A/P-loop; other site 182082000269 ATP binding site [chemical binding]; other site 182082000270 Q-loop/lid; other site 182082000271 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 182082000272 pyruvate kinase; Region: pyruv_kin; TIGR01064 182082000273 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 182082000274 domain interfaces; other site 182082000275 active site 182082000276 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906 182082000277 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 182082000278 putative acyl-acceptor binding pocket; other site 182082000279 Uncharacterized conserved protein [Function unknown]; Region: COG1624 182082000280 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 182082000281 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 182082000282 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 182082000283 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 182082000284 Bacterial SH3 domain homologues; Region: SH3b; smart00287 182082000285 Bacterial SH3 domain homologues; Region: SH3b; smart00287 182082000286 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 182082000287 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 182082000288 putative active site [active] 182082000289 PhoH-like protein; Region: PhoH; pfam02562 182082000290 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 182082000291 ADP-ribose binding site [chemical binding]; other site 182082000292 Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; Region: IFab; cl00092 182082000293 N-glycosylation site [posttranslational modification]; other site 182082000294 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 182082000295 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 182082000296 HIGH motif; other site 182082000297 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 182082000298 active site 182082000299 KMSKS motif; other site 182082000300 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 182082000301 tRNA binding surface [nucleotide binding]; other site 182082000302 anticodon binding site; other site 182082000303 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 182082000304 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 182082000305 Catalytic site [active] 182082000306 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 182082000307 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 182082000308 peptide chain release factor 1; Validated; Region: prfA; PRK00591 182082000309 PCRF domain; Region: PCRF; pfam03462 182082000310 RF-1 domain; Region: RF-1; pfam00472 182082000311 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 182082000312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 182082000313 S-adenosylmethionine binding site [chemical binding]; other site 182082000314 signal recognition particle protein; Provisional; Region: PRK10867 182082000315 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 182082000316 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 182082000317 P loop; other site 182082000318 GTP binding site [chemical binding]; other site 182082000319 Signal peptide binding domain; Region: SRP_SPB; pfam02978 182082000320 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 182082000321 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 182082000322 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 182082000323 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 182082000324 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 182082000325 RNA/DNA hybrid binding site [nucleotide binding]; other site 182082000326 active site 182082000327 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 182082000328 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 182082000329 catalytic site [active] 182082000330 G-X2-G-X-G-K; other site 182082000331 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 182082000332 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 182082000333 active site 182082000334 HIGH motif; other site 182082000335 KMSKS motif; other site 182082000336 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 182082000337 tRNA binding surface [nucleotide binding]; other site 182082000338 anticodon binding site; other site 182082000339 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 182082000340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 182082000341 Walker A motif; other site 182082000342 ATP binding site [chemical binding]; other site 182082000343 Walker B motif; other site 182082000344 Family description; Region: UvrD_C_2; pfam13538 182082000345 Domain of unknown function (DUF1978); Region: DUF1978; pfam09321 182082000346 Hydrogenase formation hypA family; Region: HypD; cl12072 182082000347 Domain of unknown function (DUF1978); Region: DUF1978; pfam09321 182082000348 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 182082000349 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 182082000350 conserved cys residue [active] 182082000351 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 182082000352 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 182082000353 ring oligomerisation interface [polypeptide binding]; other site 182082000354 ATP/Mg binding site [chemical binding]; other site 182082000355 stacking interactions; other site 182082000356 hinge regions; other site 182082000357 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 182082000358 oligomerisation interface [polypeptide binding]; other site 182082000359 mobile loop; other site 182082000360 roof hairpin; other site 182082000361 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 182082000362 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 182082000363 active site 182082000364 Zn binding site [ion binding]; other site 182082000365 Uncharacterized conserved protein [Function unknown]; Region: COG0327 182082000366 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 182082000367 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00615 182082000368 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 182082000369 inhibitor-cofactor binding pocket; inhibition site 182082000370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 182082000371 catalytic residue [active] 182082000372 Putative transcriptional regulator [Transcription]; Region: COG1678 182082000373 Uncharacterized conserved protein [Function unknown]; Region: COG1259 182082000374 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 182082000375 tetramer (dimer of dimers) interface [polypeptide binding]; other site 182082000376 active site 182082000377 dimer interface [polypeptide binding]; other site 182082000378 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 182082000379 substrate binding site [chemical binding]; other site 182082000380 THF binding site; other site 182082000381 zinc-binding site [ion binding]; other site 182082000382 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 182082000383 Clp amino terminal domain; Region: Clp_N; pfam02861 182082000384 Clp amino terminal domain; Region: Clp_N; pfam02861 182082000385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 182082000386 Walker A motif; other site 182082000387 ATP binding site [chemical binding]; other site 182082000388 Walker B motif; other site 182082000389 arginine finger; other site 182082000390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 182082000391 Walker A motif; other site 182082000392 ATP binding site [chemical binding]; other site 182082000393 Walker B motif; other site 182082000394 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 182082000395 Uncharacterized conserved protein [Function unknown]; Region: COG2912 182082000396 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 182082000397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 182082000398 TPR motif; other site 182082000399 binding surface 182082000400 TPR repeat; Region: TPR_11; pfam13414 182082000401 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 182082000402 Catalytic domain of Protein Kinases; Region: PKc; cd00180 182082000403 active site 182082000404 ATP binding site [chemical binding]; other site 182082000405 substrate binding site [chemical binding]; other site 182082000406 activation loop (A-loop); other site 182082000407 Uncharacterized conserved protein [Function unknown]; Region: COG1262 182082000408 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 182082000409 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 182082000410 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 182082000411 nucleotide binding pocket [chemical binding]; other site 182082000412 K-X-D-G motif; other site 182082000413 catalytic site [active] 182082000414 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 182082000415 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 182082000416 Helix-hairpin-helix motif; Region: HHH; pfam00633 182082000417 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 182082000418 Dimer interface [polypeptide binding]; other site 182082000419 BRCT sequence motif; other site 182082000420 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 182082000421 TrkA-N domain; Region: TrkA_N; pfam02254 182082000422 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 182082000423 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 182082000424 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 182082000425 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 182082000426 HIGH motif; other site 182082000427 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 182082000428 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 182082000429 active site 182082000430 KMSKS motif; other site 182082000431 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 182082000432 tRNA binding surface [nucleotide binding]; other site 182082000433 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 182082000434 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 182082000435 Family of unknown function (DUF648); Region: DUF648; pfam04890 182082000436 Family of unknown function (DUF648); Region: DUF648; pfam04890 182082000437 Family of unknown function (DUF648); Region: DUF648; pfam04890 182082000438 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 182082000439 active site 182082000440 ADP/pyrophosphate binding site [chemical binding]; other site 182082000441 dimerization interface [polypeptide binding]; other site 182082000442 allosteric effector site; other site 182082000443 fructose-1,6-bisphosphate binding site; other site 182082000444 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 182082000445 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 182082000446 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 182082000447 Family of unknown function (DUF648); Region: DUF648; pfam04890 182082000448 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 182082000449 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 182082000450 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 182082000451 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 182082000452 AMP/PPi binding site [chemical binding]; other site 182082000453 candidate oxyanion hole; other site 182082000454 catalytic triad [active] 182082000455 potential glutamine specificity residues [chemical binding]; other site 182082000456 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 182082000457 ATP Binding subdomain [chemical binding]; other site 182082000458 Dimerization subdomain; other site 182082000459 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 182082000460 active site 182082000461 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 182082000462 membrane-attack complex / perforin; Region: MACPF; smart00457 182082000463 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 182082000464 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 182082000465 putative active site pocket [active] 182082000466 dimerization interface [polypeptide binding]; other site 182082000467 putative catalytic residue [active] 182082000468 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 182082000469 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 182082000470 ATP-grasp domain; Region: ATP-grasp_4; cl17255 182082000471 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 182082000472 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 182082000473 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 182082000474 carboxyltransferase (CT) interaction site; other site 182082000475 biotinylation site [posttranslational modification]; other site 182082000476 elongation factor P; Provisional; Region: PRK12426 182082000477 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 182082000478 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 182082000479 RNA binding site [nucleotide binding]; other site 182082000480 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 182082000481 RNA binding site [nucleotide binding]; other site 182082000482 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 182082000483 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 182082000484 substrate binding site [chemical binding]; other site 182082000485 hexamer interface [polypeptide binding]; other site 182082000486 metal binding site [ion binding]; metal-binding site 182082000487 IncA protein; Region: IncA; pfam04156 182082000488 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 182082000489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 182082000490 S-adenosylmethionine binding site [chemical binding]; other site 182082000491 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 182082000492 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 182082000493 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 182082000494 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 182082000495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 182082000496 Walker A/P-loop; other site 182082000497 ATP binding site [chemical binding]; other site 182082000498 Q-loop/lid; other site 182082000499 ABC transporter signature motif; other site 182082000500 Walker B; other site 182082000501 D-loop; other site 182082000502 H-loop/switch region; other site 182082000503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 182082000504 dimer interface [polypeptide binding]; other site 182082000505 conserved gate region; other site 182082000506 putative PBP binding loops; other site 182082000507 ABC-ATPase subunit interface; other site 182082000508 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 182082000509 arginine repressor; Region: argR_whole; TIGR01529 182082000510 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 182082000511 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 182082000512 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 182082000513 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 182082000514 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 182082000515 peptide binding site [polypeptide binding]; other site 182082000516 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 182082000517 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 182082000518 peptide binding site [polypeptide binding]; other site 182082000519 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 182082000520 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 182082000521 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 182082000522 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 182082000523 peptide binding site [polypeptide binding]; other site 182082000524 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 182082000525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 182082000526 dimer interface [polypeptide binding]; other site 182082000527 conserved gate region; other site 182082000528 putative PBP binding loops; other site 182082000529 ABC-ATPase subunit interface; other site 182082000530 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 182082000531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 182082000532 putative PBP binding loops; other site 182082000533 dimer interface [polypeptide binding]; other site 182082000534 ABC-ATPase subunit interface; other site 182082000535 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 182082000536 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 182082000537 Walker A/P-loop; other site 182082000538 ATP binding site [chemical binding]; other site 182082000539 Q-loop/lid; other site 182082000540 ABC transporter signature motif; other site 182082000541 Walker B; other site 182082000542 D-loop; other site 182082000543 H-loop/switch region; other site 182082000544 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 182082000545 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 182082000546 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 182082000547 Walker A/P-loop; other site 182082000548 ATP binding site [chemical binding]; other site 182082000549 Q-loop/lid; other site 182082000550 ABC transporter signature motif; other site 182082000551 Walker B; other site 182082000552 D-loop; other site 182082000553 H-loop/switch region; other site 182082000554 Family of unknown function (DUF648); Region: DUF648; pfam04890 182082000555 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 182082000556 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 182082000557 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 182082000558 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 182082000559 transmembrane helices; other site 182082000560 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 182082000561 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 182082000562 active site 182082000563 ADP/pyrophosphate binding site [chemical binding]; other site 182082000564 dimerization interface [polypeptide binding]; other site 182082000565 allosteric effector site; other site 182082000566 fructose-1,6-bisphosphate binding site; other site 182082000567 Family of unknown function (DUF648); Region: DUF648; pfam04890 182082000568 IncA protein; Region: IncA; pfam04156 182082000569 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 182082000570 conserved hypothetical integral membrane protein; Region: TIGR00697 182082000571 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 182082000572 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 182082000573 putative replication initiation protein; Region: PHA00330 182082000574 IncA protein; Region: IncA; pfam04156 182082000575 putative disulfide oxidoreductase; Provisional; Region: PRK00611 182082000576 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 182082000577 Thioredoxin; Region: Thioredoxin_4; pfam13462 182082000578 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 182082000579 putative active site [active] 182082000580 redox center [active] 182082000581 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 182082000582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 182082000583 Walker A/P-loop; other site 182082000584 ATP binding site [chemical binding]; other site 182082000585 Q-loop/lid; other site 182082000586 ABC transporter signature motif; other site 182082000587 Walker B; other site 182082000588 D-loop; other site 182082000589 H-loop/switch region; other site 182082000590 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 182082000591 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 182082000592 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 182082000593 Ligand binding site; other site 182082000594 oligomer interface; other site 182082000595 CTP synthetase; Validated; Region: pyrG; PRK05380 182082000596 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 182082000597 Catalytic site [active] 182082000598 active site 182082000599 UTP binding site [chemical binding]; other site 182082000600 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 182082000601 active site 182082000602 putative oxyanion hole; other site 182082000603 catalytic triad [active] 182082000604 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 182082000605 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 182082000606 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 182082000607 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 182082000608 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 182082000609 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 182082000610 putative active site [active] 182082000611 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 182082000612 adenylate kinase; Region: adk; TIGR01351 182082000613 AMP-binding site [chemical binding]; other site 182082000614 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 182082000615 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 182082000616 NlpC/P60 family; Region: NLPC_P60; cl17555 182082000617 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 182082000618 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 182082000619 23S rRNA interface [nucleotide binding]; other site 182082000620 L3 interface [polypeptide binding]; other site 182082000621 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 182082000622 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 182082000623 Walker A/P-loop; other site 182082000624 ATP binding site [chemical binding]; other site 182082000625 Q-loop/lid; other site 182082000626 ABC transporter signature motif; other site 182082000627 Walker B; other site 182082000628 D-loop; other site 182082000629 H-loop/switch region; other site 182082000630 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 182082000631 FtsX-like permease family; Region: FtsX; pfam02687 182082000632 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 182082000633 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 182082000634 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 182082000635 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 182082000636 SEC-C motif; Region: SEC-C; pfam02810 182082000637 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 182082000638 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 182082000639 Ligand Binding Site [chemical binding]; other site 182082000640 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 182082000641 Uncharacterized conserved protein [Function unknown]; Region: COG1284 182082000642 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 182082000643 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 182082000644 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 182082000645 aromatic acid decarboxylase; Validated; Region: PRK05920 182082000646 Flavoprotein; Region: Flavoprotein; pfam02441 182082000647 prenyltransferase; Reviewed; Region: ubiA; PRK12876 182082000648 UbiA prenyltransferase family; Region: UbiA; pfam01040 182082000649 IncA protein; Region: IncA; pfam04156 182082000650 IncA protein; Region: IncA; pfam04156 182082000651 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 182082000652 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 182082000653 active site 182082000654 dimer interface [polypeptide binding]; other site 182082000655 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 182082000656 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 182082000657 Serine hydrolase (FSH1); Region: FSH1; pfam03959 182082000658 DNA polymerase III subunit delta'; Validated; Region: PRK05917 182082000659 DNA polymerase III subunit delta'; Validated; Region: PRK08485 182082000660 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 182082000661 thymidylate kinase; Validated; Region: tmk; PRK00698 182082000662 TMP-binding site; other site 182082000663 ATP-binding site [chemical binding]; other site 182082000664 DNA gyrase, A subunit; Region: gyrA; TIGR01063 182082000665 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 182082000666 CAP-like domain; other site 182082000667 active site 182082000668 primary dimer interface [polypeptide binding]; other site 182082000669 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 182082000670 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 182082000671 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 182082000672 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 182082000673 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 182082000674 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 182082000675 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 182082000676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 182082000677 ATP binding site [chemical binding]; other site 182082000678 Mg2+ binding site [ion binding]; other site 182082000679 G-X-G motif; other site 182082000680 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 182082000681 anchoring element; other site 182082000682 dimer interface [polypeptide binding]; other site 182082000683 ATP binding site [chemical binding]; other site 182082000684 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 182082000685 active site 182082000686 putative metal-binding site [ion binding]; other site 182082000687 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 182082000688 Protein of unknown function (DUF721); Region: DUF721; cl02324 182082000689 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 182082000690 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 182082000691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 182082000692 dimer interface [polypeptide binding]; other site 182082000693 conserved gate region; other site 182082000694 putative PBP binding loops; other site 182082000695 ABC-ATPase subunit interface; other site 182082000696 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 182082000697 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 182082000698 Walker A/P-loop; other site 182082000699 ATP binding site [chemical binding]; other site 182082000700 Q-loop/lid; other site 182082000701 ABC transporter signature motif; other site 182082000702 Walker B; other site 182082000703 D-loop; other site 182082000704 H-loop/switch region; other site 182082000705 NIL domain; Region: NIL; pfam09383 182082000706 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 182082000707 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 182082000708 putative active site; other site 182082000709 catalytic residue [active] 182082000710 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 182082000711 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 182082000712 MgtE intracellular N domain; Region: MgtE_N; pfam03448 182082000713 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 182082000714 Divalent cation transporter; Region: MgtE; pfam01769 182082000715 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 182082000716 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 182082000717 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 182082000718 Na2 binding site [ion binding]; other site 182082000719 putative substrate binding site 1 [chemical binding]; other site 182082000720 Na binding site 1 [ion binding]; other site 182082000721 putative substrate binding site 2 [chemical binding]; other site 182082000722 TLC ATP/ADP transporter; Region: TLC; cl03940 182082000723 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 182082000724 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 182082000725 ligand binding site [chemical binding]; other site 182082000726 flexible hinge region; other site 182082000727 acyl carrier protein; Provisional; Region: acpP; PRK00982 182082000728 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 182082000729 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 182082000730 NAD(P) binding site [chemical binding]; other site 182082000731 homotetramer interface [polypeptide binding]; other site 182082000732 homodimer interface [polypeptide binding]; other site 182082000733 active site 182082000734 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 182082000735 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 182082000736 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 182082000737 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 182082000738 dimer interface [polypeptide binding]; other site 182082000739 active site 182082000740 CoA binding pocket [chemical binding]; other site 182082000741 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 182082000742 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 182082000743 putative active site [active] 182082000744 putative metal-binding site [ion binding]; other site 182082000745 tetramer interface [polypeptide binding]; other site 182082000746 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 182082000747 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 182082000748 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 182082000749 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 182082000750 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 182082000751 Surface antigen; Region: Bac_surface_Ag; pfam01103 182082000752 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 182082000753 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 182082000754 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 182082000755 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 182082000756 trimer interface [polypeptide binding]; other site 182082000757 active site 182082000758 UDP-GlcNAc binding site [chemical binding]; other site 182082000759 lipid binding site [chemical binding]; lipid-binding site 182082000760 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 182082000761 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 182082000762 tetramer interface [polypeptide binding]; other site 182082000763 TPP-binding site [chemical binding]; other site 182082000764 heterodimer interface [polypeptide binding]; other site 182082000765 phosphorylation loop region [posttranslational modification] 182082000766 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 182082000767 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 182082000768 alpha subunit interface [polypeptide binding]; other site 182082000769 TPP binding site [chemical binding]; other site 182082000770 heterodimer interface [polypeptide binding]; other site 182082000771 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 182082000772 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 182082000773 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 182082000774 E3 interaction surface; other site 182082000775 lipoyl attachment site [posttranslational modification]; other site 182082000776 e3 binding domain; Region: E3_binding; pfam02817 182082000777 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 182082000778 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 182082000779 homodimer interface [polypeptide binding]; other site 182082000780 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 182082000781 active site pocket [active] 182082000782 chromosomal replication initiation protein; Provisional; Region: PRK12422 182082000783 DnaA N-terminal domain; Region: DnaA_N; pfam11638 182082000784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 182082000785 Walker A motif; other site 182082000786 ATP binding site [chemical binding]; other site 182082000787 Walker B motif; other site 182082000788 arginine finger; other site 182082000789 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 182082000790 DnaA box-binding interface [nucleotide binding]; other site 182082000791 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 182082000792 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 182082000793 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 182082000794 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 182082000795 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 182082000796 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 182082000797 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 182082000798 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 182082000799 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 182082000800 RNA binding site [nucleotide binding]; other site 182082000801 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 182082000802 RNA binding site [nucleotide binding]; other site 182082000803 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 182082000804 RNA binding site [nucleotide binding]; other site 182082000805 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 182082000806 RNA binding site [nucleotide binding]; other site 182082000807 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 182082000808 RNA binding site [nucleotide binding]; other site 182082000809 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 182082000810 RNA binding site [nucleotide binding]; other site 182082000811 transcription termination factor NusA; Region: NusA; TIGR01953 182082000812 NusA N-terminal domain; Region: NusA_N; pfam08529 182082000813 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 182082000814 RNA binding site [nucleotide binding]; other site 182082000815 homodimer interface [polypeptide binding]; other site 182082000816 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 182082000817 G-X-X-G motif; other site 182082000818 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 182082000819 G-X-X-G motif; other site 182082000820 translation initiation factor IF-2; Validated; Region: infB; PRK05306 182082000821 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 182082000822 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 182082000823 G1 box; other site 182082000824 putative GEF interaction site [polypeptide binding]; other site 182082000825 GTP/Mg2+ binding site [chemical binding]; other site 182082000826 Switch I region; other site 182082000827 G2 box; other site 182082000828 G3 box; other site 182082000829 Switch II region; other site 182082000830 G4 box; other site 182082000831 G5 box; other site 182082000832 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 182082000833 Translation-initiation factor 2; Region: IF-2; pfam11987 182082000834 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 182082000835 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 182082000836 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 182082000837 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 182082000838 RNA binding site [nucleotide binding]; other site 182082000839 active site 182082000840 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 182082000841 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 182082000842 active site 182082000843 Riboflavin kinase; Region: Flavokinase; pfam01687 182082000844 GTP-binding protein YchF; Reviewed; Region: PRK09601 182082000845 YchF GTPase; Region: YchF; cd01900 182082000846 G1 box; other site 182082000847 GTP/Mg2+ binding site [chemical binding]; other site 182082000848 Switch I region; other site 182082000849 G2 box; other site 182082000850 Switch II region; other site 182082000851 G3 box; other site 182082000852 G4 box; other site 182082000853 G5 box; other site 182082000854 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 182082000855 type III secretion system protein; Validated; Region: PRK06298 182082000856 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 182082000857 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 182082000858 FHIPEP family; Region: FHIPEP; pfam00771 182082000859 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 182082000860 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 182082000861 4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446 182082000862 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 182082000863 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 182082000864 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 182082000865 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 182082000866 PLD-like domain; Region: PLDc_2; pfam13091 182082000867 putative active site [active] 182082000868 catalytic site [active] 182082000869 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 182082000870 PLD-like domain; Region: PLDc_2; pfam13091 182082000871 putative active site [active] 182082000872 catalytic site [active] 182082000873 molecular chaperone DnaK; Provisional; Region: PRK13410 182082000874 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 182082000875 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 182082000876 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 182082000877 homodimer interface [polypeptide binding]; other site 182082000878 NADP binding site [chemical binding]; other site 182082000879 substrate binding site [chemical binding]; other site 182082000880 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 182082000881 ApbE family; Region: ApbE; pfam02424 182082000882 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 182082000883 SmpB-tmRNA interface; other site 182082000884 DNA polymerase III subunit beta; Validated; Region: PRK05643 182082000885 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 182082000886 putative DNA binding surface [nucleotide binding]; other site 182082000887 dimer interface [polypeptide binding]; other site 182082000888 beta-clamp/clamp loader binding surface; other site 182082000889 beta-clamp/translesion DNA polymerase binding surface; other site 182082000890 similar to Bacillus subilis RecF; contains frameshift 182082000891 Putative serine esterase (DUF676); Region: DUF676; pfam05057 182082000892 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 182082000893 RIP metalloprotease RseP; Region: TIGR00054 182082000894 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 182082000895 active site 182082000896 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 182082000897 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 182082000898 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 182082000899 putative substrate binding region [chemical binding]; other site 182082000900 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 182082000901 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 182082000902 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 182082000903 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 182082000904 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 182082000905 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 182082000906 ABC-ATPase subunit interface; other site 182082000907 dimer interface [polypeptide binding]; other site 182082000908 putative PBP binding regions; other site 182082000909 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 182082000910 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 182082000911 ABC-ATPase subunit interface; other site 182082000912 dimer interface [polypeptide binding]; other site 182082000913 putative PBP binding regions; other site 182082000914 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 182082000915 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 182082000916 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 182082000917 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 182082000918 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 182082000919 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 182082000920 metal binding site [ion binding]; metal-binding site 182082000921 intersubunit interface [polypeptide binding]; other site 182082000922 ADP/ATP carrier protein family; Region: AAA; TIGR00769 182082000923 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 182082000924 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 182082000925 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 182082000926 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 182082000927 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 182082000928 GTP-binding protein LepA; Provisional; Region: PRK05433 182082000929 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 182082000930 G1 box; other site 182082000931 putative GEF interaction site [polypeptide binding]; other site 182082000932 GTP/Mg2+ binding site [chemical binding]; other site 182082000933 Switch I region; other site 182082000934 G2 box; other site 182082000935 G3 box; other site 182082000936 Switch II region; other site 182082000937 G4 box; other site 182082000938 G5 box; other site 182082000939 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 182082000940 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 182082000941 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 182082000942 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 182082000943 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 182082000944 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 182082000945 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 182082000946 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 182082000947 active site 182082000948 HIGH motif; other site 182082000949 dimer interface [polypeptide binding]; other site 182082000950 KMSKS motif; other site 182082000951 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 182082000952 RNA binding surface [nucleotide binding]; other site 182082000953 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 182082000954 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 182082000955 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 182082000956 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 182082000957 DNA binding residues [nucleotide binding] 182082000958 type III secretion system protein; Validated; Region: PRK05910 182082000959 FHIPEP family; Region: FHIPEP; pfam00771 182082000960 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 182082000961 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 182082000962 catalytic loop [active] 182082000963 iron binding site [ion binding]; other site 182082000964 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 182082000965 ADP-ribose binding site [chemical binding]; other site 182082000966 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 182082000967 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 182082000968 ADP-ribose binding site [chemical binding]; other site 182082000969 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 182082000970 ADP-ribose binding site [chemical binding]; other site 182082000971 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 182082000972 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 182082000973 uncharacterized protein, YfiH family; Region: TIGR00726 182082000974 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 182082000975 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 182082000976 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 182082000977 E3 interaction surface; other site 182082000978 lipoyl attachment site [posttranslational modification]; other site 182082000979 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 182082000980 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 182082000981 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 182082000982 TPP-binding site [chemical binding]; other site 182082000983 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 182082000984 dimer interface [polypeptide binding]; other site 182082000985 PYR/PP interface [polypeptide binding]; other site 182082000986 TPP binding site [chemical binding]; other site 182082000987 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 182082000988 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 182082000989 FeS/SAM binding site; other site 182082000990 Protein of unknown function (DUF687); Region: DUF687; pfam05095 182082000991 Predicted methyltransferases [General function prediction only]; Region: COG0313 182082000992 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 182082000993 putative SAM binding site [chemical binding]; other site 182082000994 homodimer interface [polypeptide binding]; other site 182082000995 hypothetical protein; Provisional; Region: PRK05907 182082000996 multifunctional aminopeptidase A; Provisional; Region: PRK00913 182082000997 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 182082000998 interface (dimer of trimers) [polypeptide binding]; other site 182082000999 Substrate-binding/catalytic site; other site 182082001000 Zn-binding sites [ion binding]; other site 182082001001 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 182082001002 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 182082001003 ssDNA binding site [nucleotide binding]; other site 182082001004 dimer interface [polypeptide binding]; other site 182082001005 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 182082001006 tetramer (dimer of dimers) interface [polypeptide binding]; other site 182082001007 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 182082001008 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 182082001009 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 182082001010 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 182082001011 active site 182082001012 catalytic site [active] 182082001013 Stage II sporulation protein; Region: SpoIID; pfam08486 182082001014 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 182082001015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 182082001016 Walker A motif; other site 182082001017 ATP binding site [chemical binding]; other site 182082001018 Walker B motif; other site 182082001019 arginine finger; other site 182082001020 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 182082001021 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 182082001022 trimer interface [polypeptide binding]; other site 182082001023 active site 182082001024 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 182082001025 Domain of unknown function DUF21; Region: DUF21; pfam01595 182082001026 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 182082001027 Transporter associated domain; Region: CorC_HlyC; smart01091 182082001028 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 182082001029 Domain of unknown function DUF21; Region: DUF21; pfam01595 182082001030 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 182082001031 Transporter associated domain; Region: CorC_HlyC; smart01091 182082001032 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 182082001033 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 182082001034 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 182082001035 catalytic residue [active] 182082001036 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 182082001037 active site 182082001038 CAAX protease self-immunity; Region: Abi; pfam02517 182082001039 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 182082001040 homodimer interface [polypeptide binding]; other site 182082001041 metal binding site [ion binding]; metal-binding site 182082001042 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 182082001043 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 182082001044 minor groove reading motif; other site 182082001045 helix-hairpin-helix signature motif; other site 182082001046 substrate binding pocket [chemical binding]; other site 182082001047 active site 182082001048 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 182082001049 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 182082001050 DNA binding and oxoG recognition site [nucleotide binding] 182082001051 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 182082001052 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 182082001053 RNA binding surface [nucleotide binding]; other site 182082001054 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 182082001055 active site 182082001056 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 182082001057 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 182082001058 NAD binding site [chemical binding]; other site 182082001059 homotetramer interface [polypeptide binding]; other site 182082001060 homodimer interface [polypeptide binding]; other site 182082001061 substrate binding site [chemical binding]; other site 182082001062 active site 182082001063 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 182082001064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 182082001065 active site 182082001066 motif I; other site 182082001067 motif II; other site 182082001068 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 182082001069 Uncharacterized conserved protein [Function unknown]; Region: COG5465 182082001070 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 182082001071 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 182082001072 active site 182082001073 catalytic site [active] 182082001074 substrate binding site [chemical binding]; other site 182082001075 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 182082001076 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 182082001077 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 182082001078 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 182082001079 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 182082001080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 182082001081 Walker A/P-loop; other site 182082001082 ATP binding site [chemical binding]; other site 182082001083 Q-loop/lid; other site 182082001084 ABC transporter signature motif; other site 182082001085 Walker B; other site 182082001086 D-loop; other site 182082001087 H-loop/switch region; other site 182082001088 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 182082001089 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 182082001090 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 182082001091 IHF - DNA interface [nucleotide binding]; other site 182082001092 IHF dimer interface [polypeptide binding]; other site 182082001093 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 182082001094 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 182082001095 active site 182082001096 metal binding site [ion binding]; metal-binding site 182082001097 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 182082001098 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 182082001099 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 182082001100 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 182082001101 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 182082001102 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 182082001103 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 182082001104 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 182082001105 MraW methylase family; Region: Methyltransf_5; cl17771 182082001106 TPR repeat; Region: TPR_11; pfam13414 182082001107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 182082001108 TPR motif; other site 182082001109 binding surface 182082001110 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 182082001111 DnaA N-terminal domain; Region: DnaA_N; pfam11638 182082001112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 182082001113 Walker A motif; other site 182082001114 ATP binding site [chemical binding]; other site 182082001115 Walker B motif; other site 182082001116 arginine finger; other site 182082001117 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 182082001118 DnaA box-binding interface [nucleotide binding]; other site 182082001119 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 182082001120 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 182082001121 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 182082001122 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 182082001123 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 182082001124 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 182082001125 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 182082001126 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 182082001127 lipoyl attachment site [posttranslational modification]; other site 182082001128 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 182082001129 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 182082001130 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 182082001131 putative active site [active] 182082001132 catalytic site [active] 182082001133 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 182082001134 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 182082001135 Clp amino terminal domain; Region: Clp_N; pfam02861 182082001136 Clp amino terminal domain; Region: Clp_N; pfam02861 182082001137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 182082001138 Walker A motif; other site 182082001139 ATP binding site [chemical binding]; other site 182082001140 Walker B motif; other site 182082001141 arginine finger; other site 182082001142 UvrB/uvrC motif; Region: UVR; pfam02151 182082001143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 182082001144 Walker A motif; other site 182082001145 ATP binding site [chemical binding]; other site 182082001146 Walker B motif; other site 182082001147 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 182082001148 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 182082001149 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 182082001150 Ligand Binding Site [chemical binding]; other site 182082001151 Cell division protein ZapA; Region: ZapA; cl01146 182082001152 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 182082001153 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 182082001154 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082001155 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082001156 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082001157 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082001158 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082001159 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082001160 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 182082001161 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082001162 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082001163 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 182082001164 substrate binding site [chemical binding]; other site 182082001165 zinc-binding site [ion binding]; other site 182082001166 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 182082001167 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 182082001168 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082001169 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082001170 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 182082001171 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082001172 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082001173 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082001174 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082001175 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082001176 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082001177 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082001178 Protein of unknown function (DUF575); Region: DUF575; pfam04746 182082001179 Protein of unknown function (DUF562); Region: DUF562; pfam04763 182082001180 Protein of unknown function (DUF575); Region: DUF575; pfam04746 182082001181 Protein of unknown function (DUF562); Region: DUF562; pfam04763 182082001182 Protein of unknown function (DUF575); Region: DUF575; pfam04746 182082001183 Protein of unknown function (DUF562); Region: DUF562; pfam04763 182082001184 Protein of unknown function (DUF562); Region: DUF562; pfam04763 182082001185 Protein of unknown function (DUF575); Region: DUF575; pfam04746 182082001186 Protein of unknown function (DUF575); Region: DUF575; pfam04746 182082001187 Protein of unknown function (DUF562); Region: DUF562; pfam04763 182082001188 Protein of unknown function (DUF562); Region: DUF562; pfam04763 182082001189 Protein of unknown function (DUF575); Region: DUF575; pfam04746 182082001190 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 182082001191 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082001192 Autotransporter beta-domain; Region: Autotransporter; smart00869 182082001193 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082001194 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082001195 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082001196 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082001197 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082001198 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 182082001199 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 182082001200 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082001201 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082001202 glycogen branching enzyme; Provisional; Region: PRK05402 182082001203 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 182082001204 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 182082001205 active site 182082001206 catalytic site [active] 182082001207 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 182082001208 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 182082001209 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 182082001210 GTPases [General function prediction only]; Region: HflX; COG2262 182082001211 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 182082001212 HflX GTPase family; Region: HflX; cd01878 182082001213 G1 box; other site 182082001214 GTP/Mg2+ binding site [chemical binding]; other site 182082001215 Switch I region; other site 182082001216 G2 box; other site 182082001217 G3 box; other site 182082001218 Switch II region; other site 182082001219 G4 box; other site 182082001220 G5 box; other site 182082001221 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 182082001222 putative hydrolase; Provisional; Region: PRK02113 182082001223 Protein of unknown function (DUF3487); Region: DUF3487; cl13432 182082001224 similar to Chlamydophila pneumoniae CWL029 hypothetical protein; contains frameshift 182082001225 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 182082001226 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 182082001227 substrate binding pocket [chemical binding]; other site 182082001228 membrane-bound complex binding site; other site 182082001229 hinge residues; other site 182082001230 Peptidase C65 Otubain; Region: Peptidase_C65; pfam10275 182082001231 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 182082001232 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 182082001233 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 182082001234 Na binding site [ion binding]; other site 182082001235 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 182082001236 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 182082001237 nucleotide binding site/active site [active] 182082001238 HIT family signature motif; other site 182082001239 catalytic residue [active] 182082001240 Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286 182082001241 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 182082001242 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 182082001243 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 182082001244 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 182082001245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 182082001246 homodimer interface [polypeptide binding]; other site 182082001247 catalytic residue [active] 182082001248 ABC transporter substrate binding protein; Region: ABC_sub_bind; pfam04392 182082001249 hypothetical protein; Validated; Region: PRK00647 182082001250 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 182082001251 Acetokinase family; Region: Acetate_kinase; cl17229 182082001252 prolyl-tRNA synthetase; Provisional; Region: PRK09194 182082001253 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 182082001254 motif 1; other site 182082001255 dimer interface [polypeptide binding]; other site 182082001256 active site 182082001257 motif 2; other site 182082001258 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 182082001259 putative deacylase active site [active] 182082001260 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 182082001261 active site 182082001262 motif 3; other site 182082001263 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 182082001264 anticodon binding site; other site 182082001265 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 182082001266 GrpE; Region: GrpE; pfam01025 182082001267 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 182082001268 dimer interface [polypeptide binding]; other site 182082001269 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 182082001270 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 182082001271 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 182082001272 nucleotide binding site [chemical binding]; other site 182082001273 NEF interaction site [polypeptide binding]; other site 182082001274 SBD interface [polypeptide binding]; other site 182082001275 Exoribonuclease R [Transcription]; Region: VacB; COG0557 182082001276 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 182082001277 RNA binding site [nucleotide binding]; other site 182082001278 RNB domain; Region: RNB; pfam00773 182082001279 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 182082001280 active site 182082001281 DNA binding site [nucleotide binding] 182082001282 Uncharacterized conserved protein [Function unknown]; Region: COG2928 182082001283 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 182082001284 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 182082001285 FOG: CBS domain [General function prediction only]; Region: COG0517 182082001286 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 182082001287 Transporter associated domain; Region: CorC_HlyC; smart01091 182082001288 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 182082001289 anti sigma factor interaction site; other site 182082001290 regulatory phosphorylation site [posttranslational modification]; other site 182082001291 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 182082001292 hypothetical protein; Provisional; Region: PRK05926 182082001293 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 182082001294 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 182082001295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 182082001296 S-adenosylmethionine binding site [chemical binding]; other site 182082001297 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907 182082001298 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 182082001299 diaminopimelate epimerase; Region: DapF; TIGR00652 182082001300 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 182082001301 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 182082001302 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 182082001303 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 182082001304 oligomer interface [polypeptide binding]; other site 182082001305 active site residues [active] 182082001306 serine hydroxymethyltransferase; Provisional; Region: PRK13580 182082001307 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 182082001308 dimer interface [polypeptide binding]; other site 182082001309 active site 182082001310 glycine-pyridoxal phosphate binding site [chemical binding]; other site 182082001311 folate binding site [chemical binding]; other site 182082001312 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 182082001313 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 182082001314 active site 182082001315 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 182082001316 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 182082001317 Putative zinc ribbon domain; Region: DUF164; pfam02591 182082001318 KpsF/GutQ family protein; Region: kpsF; TIGR00393 182082001319 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 182082001320 putative active site [active] 182082001321 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 182082001322 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 182082001323 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 182082001324 E3 interaction surface; other site 182082001325 lipoyl attachment site [posttranslational modification]; other site 182082001326 e3 binding domain; Region: E3_binding; pfam02817 182082001327 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 182082001328 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 182082001329 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 182082001330 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 182082001331 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 182082001332 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 182082001333 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 182082001334 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 182082001335 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 182082001336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 182082001337 S-adenosylmethionine binding site [chemical binding]; other site 182082001338 Riboflavin synthase alpha chain [Coenzyme metabolism]; Region: RibC; COG0307 182082001339 Lumazine binding domain; Region: Lum_binding; pfam00677 182082001340 Lumazine binding domain; Region: Lum_binding; pfam00677 182082001341 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 182082001342 ATP cone domain; Region: ATP-cone; pfam03477 182082001343 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 182082001344 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 182082001345 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 182082001346 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 182082001347 YtxH-like protein; Region: YtxH; pfam12732 182082001348 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082001349 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082001350 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082001351 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082001352 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 182082001353 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 182082001354 putative metal binding residues [ion binding]; other site 182082001355 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 182082001356 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 182082001357 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 182082001358 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 182082001359 ABC-ATPase subunit interface; other site 182082001360 dimer interface [polypeptide binding]; other site 182082001361 putative PBP binding regions; other site 182082001362 GTPase CgtA; Reviewed; Region: obgE; PRK12299 182082001363 GTP1/OBG; Region: GTP1_OBG; pfam01018 182082001364 Obg GTPase; Region: Obg; cd01898 182082001365 G1 box; other site 182082001366 GTP/Mg2+ binding site [chemical binding]; other site 182082001367 Switch I region; other site 182082001368 G2 box; other site 182082001369 G3 box; other site 182082001370 Switch II region; other site 182082001371 G4 box; other site 182082001372 G5 box; other site 182082001373 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 182082001374 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 182082001375 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 182082001376 homotrimer interaction site [polypeptide binding]; other site 182082001377 zinc binding site [ion binding]; other site 182082001378 CDP-binding sites; other site 182082001379 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 182082001380 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 182082001381 FAD binding pocket [chemical binding]; other site 182082001382 conserved FAD binding motif [chemical binding]; other site 182082001383 phosphate binding motif [ion binding]; other site 182082001384 beta-alpha-beta structure motif; other site 182082001385 NAD binding pocket [chemical binding]; other site 182082001386 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 182082001387 elongation factor G; Reviewed; Region: PRK12739 182082001388 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 182082001389 G1 box; other site 182082001390 putative GEF interaction site [polypeptide binding]; other site 182082001391 GTP/Mg2+ binding site [chemical binding]; other site 182082001392 Switch I region; other site 182082001393 G2 box; other site 182082001394 G3 box; other site 182082001395 Switch II region; other site 182082001396 G4 box; other site 182082001397 G5 box; other site 182082001398 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 182082001399 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 182082001400 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 182082001401 30S ribosomal protein S7; Validated; Region: PRK05302 182082001402 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 182082001403 S17 interaction site [polypeptide binding]; other site 182082001404 S8 interaction site; other site 182082001405 16S rRNA interaction site [nucleotide binding]; other site 182082001406 streptomycin interaction site [chemical binding]; other site 182082001407 23S rRNA interaction site [nucleotide binding]; other site 182082001408 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 182082001409 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 182082001410 Opioid growth factor receptor (OGFr) conserved region; Region: OGFr_N; pfam04664 182082001411 C-terminal peptidase (prc); Region: prc; TIGR00225 182082001412 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 182082001413 protein binding site [polypeptide binding]; other site 182082001414 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 182082001415 Catalytic dyad [active] 182082001416 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 182082001417 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 182082001418 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 182082001419 Domain of unknown function DUF11; Region: DUF11; pfam01345 182082001420 Domain of unknown function DUF11; Region: DUF11; pfam01345 182082001421 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 182082001422 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 182082001423 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 182082001424 HIGH motif; other site 182082001425 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 182082001426 active site 182082001427 KMSKS motif; other site 182082001428 Helix-turn-helix domain; Region: HTH_17; pfam12728 182082001429 Helix-turn-helix domain; Region: HTH_17; pfam12728 182082001430 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 182082001431 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 182082001432 DHH family; Region: DHH; pfam01368 182082001433 DHHA1 domain; Region: DHHA1; pfam02272 182082001434 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 182082001435 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 182082001436 Protein export membrane protein; Region: SecD_SecF; pfam02355 182082001437 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 182082001438 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 182082001439 catalytic residue [active] 182082001440 putative FPP diphosphate binding site; other site 182082001441 putative FPP binding hydrophobic cleft; other site 182082001442 dimer interface [polypeptide binding]; other site 182082001443 putative IPP diphosphate binding site; other site 182082001444 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 182082001445 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 182082001446 cytidylate kinase; Provisional; Region: cmk; PRK00023 182082001447 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 182082001448 CMP-binding site; other site 182082001449 The sites determining sugar specificity; other site 182082001450 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 182082001451 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 182082001452 putative acyl-acceptor binding pocket; other site 182082001453 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 182082001454 arginine-tRNA ligase; Region: PLN02286 182082001455 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 182082001456 active site 182082001457 HIGH motif; other site 182082001458 KMSK motif region; other site 182082001459 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 182082001460 tRNA binding surface [nucleotide binding]; other site 182082001461 anticodon binding site; other site 182082001462 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 182082001463 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 182082001464 hinge; other site 182082001465 active site 182082001466 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 182082001467 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 182082001468 SprT-like family; Region: SprT-like; pfam10263 182082001469 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 182082001470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 182082001471 Coenzyme A binding pocket [chemical binding]; other site 182082001472 This domain is found in peptide chain release factors; Region: PCRF; smart00937 182082001473 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 182082001474 RF-1 domain; Region: RF-1; pfam00472 182082001475 SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531 182082001476 SWIB/MDM2 domain; Region: SWIB; pfam02201 182082001477 phosphodiesterase YaeI; Provisional; Region: PRK11340 182082001478 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 182082001479 putative active site [active] 182082001480 putative metal binding site [ion binding]; other site 182082001481 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 182082001482 substrate binding site; other site 182082001483 dimer interface; other site 182082001484 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 182082001485 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 182082001486 dimerization interface 3.5A [polypeptide binding]; other site 182082001487 active site 182082001488 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 182082001489 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 182082001490 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 182082001491 putative active site [active] 182082001492 heme pocket [chemical binding]; other site 182082001493 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 182082001494 dimer interface [polypeptide binding]; other site 182082001495 phosphorylation site [posttranslational modification] 182082001496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 182082001497 ATP binding site [chemical binding]; other site 182082001498 Mg2+ binding site [ion binding]; other site 182082001499 G-X-G motif; other site 182082001500 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 182082001501 Response regulator receiver domain; Region: Response_reg; pfam00072 182082001502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 182082001503 active site 182082001504 phosphorylation site [posttranslational modification] 182082001505 intermolecular recognition site; other site 182082001506 dimerization interface [polypeptide binding]; other site 182082001507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 182082001508 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 182082001509 Walker A motif; other site 182082001510 ATP binding site [chemical binding]; other site 182082001511 Walker B motif; other site 182082001512 arginine finger; other site 182082001513 Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis]; Region: COG1544 182082001514 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 182082001515 Recombination protein O N terminal; Region: RecO_N; pfam11967 182082001516 DNA repair protein RecO; Region: reco; TIGR00613 182082001517 Recombination protein O C terminal; Region: RecO_C; pfam02565 182082001518 Uncharacterized conserved protein [Function unknown]; Region: COG1723 182082001519 hypothetical protein; Provisional; Region: PRK14381 182082001520 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 182082001521 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 182082001522 phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472 182082001523 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 182082001524 putative tRNA-binding site [nucleotide binding]; other site 182082001525 B3/4 domain; Region: B3_4; pfam03483 182082001526 tRNA synthetase B5 domain; Region: B5; smart00874 182082001527 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 182082001528 dimer interface [polypeptide binding]; other site 182082001529 motif 1; other site 182082001530 motif 3; other site 182082001531 motif 2; other site 182082001532 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 182082001533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 182082001534 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 182082001535 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 182082001536 DNA binding site [nucleotide binding] 182082001537 active site 182082001538 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 182082001539 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 182082001540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 182082001541 dimer interface [polypeptide binding]; other site 182082001542 conserved gate region; other site 182082001543 putative PBP binding loops; other site 182082001544 ABC-ATPase subunit interface; other site 182082001545 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 182082001546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 182082001547 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 182082001548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 182082001549 dimer interface [polypeptide binding]; other site 182082001550 conserved gate region; other site 182082001551 ABC-ATPase subunit interface; other site 182082001552 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 182082001553 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 182082001554 peptide binding site [polypeptide binding]; other site 182082001555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 182082001556 TPR motif; other site 182082001557 binding surface 182082001558 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 182082001559 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 182082001560 C-terminal domain interface [polypeptide binding]; other site 182082001561 active site 182082001562 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 182082001563 active site 182082001564 N-terminal domain interface [polypeptide binding]; other site 182082001565 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 182082001566 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 182082001567 substrate binding pocket [chemical binding]; other site 182082001568 membrane-bound complex binding site; other site 182082001569 hinge residues; other site 182082001570 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 182082001571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 182082001572 S-adenosylmethionine binding site [chemical binding]; other site 182082001573 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 182082001574 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 182082001575 putative active site [active] 182082001576 putative metal binding site [ion binding]; other site 182082001577 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 182082001578 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 182082001579 ligand binding site; other site 182082001580 oligomer interface; other site 182082001581 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 182082001582 dimer interface [polypeptide binding]; other site 182082001583 N-terminal domain interface [polypeptide binding]; other site 182082001584 sulfate 1 binding site; other site 182082001585 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 182082001586 active site 182082001587 transcription termination factor Rho; Provisional; Region: rho; PRK09376 182082001588 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 182082001589 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 182082001590 RNA binding site [nucleotide binding]; other site 182082001591 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 182082001592 multimer interface [polypeptide binding]; other site 182082001593 Walker A motif; other site 182082001594 ATP binding site [chemical binding]; other site 182082001595 Walker B motif; other site 182082001596 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 182082001597 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 182082001598 CoA-binding site [chemical binding]; other site 182082001599 ATP-binding [chemical binding]; other site 182082001600 DNA polymerase I; Provisional; Region: PRK05755 182082001601 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 182082001602 active site 182082001603 metal binding site 1 [ion binding]; metal-binding site 182082001604 putative 5' ssDNA interaction site; other site 182082001605 metal binding site 3; metal-binding site 182082001606 metal binding site 2 [ion binding]; metal-binding site 182082001607 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 182082001608 putative DNA binding site [nucleotide binding]; other site 182082001609 putative metal binding site [ion binding]; other site 182082001610 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 182082001611 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 182082001612 active site 182082001613 DNA binding site [nucleotide binding] 182082001614 catalytic site [active] 182082001615 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 182082001616 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 182082001617 tandem repeat interface [polypeptide binding]; other site 182082001618 oligomer interface [polypeptide binding]; other site 182082001619 active site residues [active] 182082001620 ADP/ATP carrier protein family; Region: AAA; TIGR00769 182082001621 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 182082001622 replicative DNA helicase; Provisional; Region: PRK06321 182082001623 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 182082001624 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 182082001625 Walker A motif; other site 182082001626 ATP binding site [chemical binding]; other site 182082001627 Walker B motif; other site 182082001628 DNA binding loops [nucleotide binding] 182082001629 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 182082001630 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 182082001631 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 182082001632 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 182082001633 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 182082001634 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 182082001635 active site 182082001636 multimer interface [polypeptide binding]; other site 182082001637 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 182082001638 RuvA N terminal domain; Region: RuvA_N; pfam01330 182082001639 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 182082001640 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 182082001641 active site 182082001642 putative DNA-binding cleft [nucleotide binding]; other site 182082001643 dimer interface [polypeptide binding]; other site 182082001644 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 182082001645 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 182082001646 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 182082001647 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 182082001648 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 182082001649 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 182082001650 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 182082001651 alphaNTD - beta interaction site [polypeptide binding]; other site 182082001652 alphaNTD homodimer interface [polypeptide binding]; other site 182082001653 alphaNTD - beta' interaction site [polypeptide binding]; other site 182082001654 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 182082001655 30S ribosomal protein S11; Validated; Region: PRK05309 182082001656 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 182082001657 30S ribosomal protein S13; Region: bact_S13; TIGR03631 182082001658 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 182082001659 SecY translocase; Region: SecY; pfam00344 182082001660 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 182082001661 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 182082001662 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 182082001663 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 182082001664 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 182082001665 5S rRNA interface [nucleotide binding]; other site 182082001666 23S rRNA interface [nucleotide binding]; other site 182082001667 L5 interface [polypeptide binding]; other site 182082001668 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 182082001669 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 182082001670 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 182082001671 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 182082001672 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 182082001673 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 182082001674 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 182082001675 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 182082001676 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 182082001677 RNA binding site [nucleotide binding]; other site 182082001678 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 182082001679 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 182082001680 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 182082001681 23S rRNA interface [nucleotide binding]; other site 182082001682 putative translocon interaction site; other site 182082001683 signal recognition particle (SRP54) interaction site; other site 182082001684 L23 interface [polypeptide binding]; other site 182082001685 trigger factor interaction site; other site 182082001686 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 182082001687 23S rRNA interface [nucleotide binding]; other site 182082001688 5S rRNA interface [nucleotide binding]; other site 182082001689 putative antibiotic binding site [chemical binding]; other site 182082001690 L25 interface [polypeptide binding]; other site 182082001691 L27 interface [polypeptide binding]; other site 182082001692 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 182082001693 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 182082001694 G-X-X-G motif; other site 182082001695 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 182082001696 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 182082001697 putative translocon binding site; other site 182082001698 protein-rRNA interface [nucleotide binding]; other site 182082001699 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 182082001700 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 182082001701 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 182082001702 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 182082001703 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 182082001704 Ribosomal protein L4 [Translation, ribosomal structure and biogenesis]; Region: RplD; COG0088 182082001705 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 182082001706 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 182082001707 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 182082001708 putative active site [active] 182082001709 substrate binding site [chemical binding]; other site 182082001710 putative cosubstrate binding site; other site 182082001711 catalytic site [active] 182082001712 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 182082001713 substrate binding site [chemical binding]; other site 182082001714 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 182082001715 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 182082001716 active site 182082001717 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 182082001718 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 182082001719 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 182082001720 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 182082001721 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 182082001722 putative active site [active] 182082001723 catalytic triad [active] 182082001724 putative dimer interface [polypeptide binding]; other site 182082001725 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 182082001726 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 182082001727 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 182082001728 active site 182082001729 catalytic site [active] 182082001730 substrate binding site [chemical binding]; other site 182082001731 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 182082001732 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 182082001733 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 182082001734 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 182082001735 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 182082001736 catalytic residues [active] 182082001737 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 182082001738 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 182082001739 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 182082001740 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 182082001741 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 182082001742 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 182082001743 dimer interface [polypeptide binding]; other site 182082001744 anticodon binding site; other site 182082001745 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 182082001746 homodimer interface [polypeptide binding]; other site 182082001747 motif 1; other site 182082001748 active site 182082001749 motif 2; other site 182082001750 GAD domain; Region: GAD; pfam02938 182082001751 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 182082001752 active site 182082001753 motif 3; other site 182082001754 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 182082001755 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 182082001756 dimer interface [polypeptide binding]; other site 182082001757 motif 1; other site 182082001758 active site 182082001759 motif 2; other site 182082001760 motif 3; other site 182082001761 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 182082001762 anticodon binding site; other site 182082001763 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 182082001764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 182082001765 putative substrate translocation pore; other site 182082001766 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 182082001767 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 182082001768 active site 182082001769 PHP Thumb interface [polypeptide binding]; other site 182082001770 metal binding site [ion binding]; metal-binding site 182082001771 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 182082001772 generic binding surface I; other site 182082001773 generic binding surface II; other site 182082001774 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 182082001775 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 182082001776 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 182082001777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 182082001778 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 182082001779 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 182082001780 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 182082001781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 182082001782 S-adenosylmethionine binding site [chemical binding]; other site 182082001783 Phosphoglycerate kinase; Region: PGK; pfam00162 182082001784 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 182082001785 substrate binding site [chemical binding]; other site 182082001786 hinge regions; other site 182082001787 ADP binding site [chemical binding]; other site 182082001788 catalytic site [active] 182082001789 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 182082001790 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 182082001791 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 182082001792 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 182082001793 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 182082001794 Walker A/P-loop; other site 182082001795 ATP binding site [chemical binding]; other site 182082001796 Q-loop/lid; other site 182082001797 ABC transporter signature motif; other site 182082001798 Walker B; other site 182082001799 D-loop; other site 182082001800 H-loop/switch region; other site 182082001801 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 182082001802 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 182082001803 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 182082001804 Walker A/P-loop; other site 182082001805 ATP binding site [chemical binding]; other site 182082001806 Q-loop/lid; other site 182082001807 ABC transporter signature motif; other site 182082001808 Walker B; other site 182082001809 D-loop; other site 182082001810 H-loop/switch region; other site 182082001811 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 182082001812 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 182082001813 ParB-like nuclease domain; Region: ParBc; pfam02195 182082001814 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 182082001815 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 182082001816 putative active site [active] 182082001817 putative metal binding site [ion binding]; other site 182082001818 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 182082001819 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 182082001820 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 182082001821 catalytic residue [active] 182082001822 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 182082001823 FeS assembly protein SufD; Region: sufD; TIGR01981 182082001824 FeS assembly ATPase SufC; Region: sufC; TIGR01978 182082001825 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 182082001826 Walker A/P-loop; other site 182082001827 ATP binding site [chemical binding]; other site 182082001828 Q-loop/lid; other site 182082001829 ABC transporter signature motif; other site 182082001830 Walker B; other site 182082001831 D-loop; other site 182082001832 H-loop/switch region; other site 182082001833 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 182082001834 putative ABC transporter; Region: ycf24; CHL00085 182082001835 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 182082001836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 182082001837 binding surface 182082001838 TPR motif; other site 182082001839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 182082001840 binding surface 182082001841 TPR motif; other site 182082001842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 182082001843 binding surface 182082001844 TPR motif; other site 182082001845 TPR repeat; Region: TPR_11; pfam13414 182082001846 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 182082001847 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 182082001848 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 182082001849 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 182082001850 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 182082001851 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 182082001852 rRNA interaction site [nucleotide binding]; other site 182082001853 S8 interaction site; other site 182082001854 putative laminin-1 binding site; other site 182082001855 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 182082001856 UBA/TS-N domain; Region: UBA; pfam00627 182082001857 Elongation factor TS; Region: EF_TS; pfam00889 182082001858 Elongation factor TS; Region: EF_TS; pfam00889 182082001859 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 182082001860 putative nucleotide binding site [chemical binding]; other site 182082001861 uridine monophosphate binding site [chemical binding]; other site 182082001862 homohexameric interface [polypeptide binding]; other site 182082001863 ribosome recycling factor; Reviewed; Region: frr; PRK00083 182082001864 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 182082001865 hinge region; other site 182082001866 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 182082001867 UvrB/uvrC motif; Region: UVR; pfam02151 182082001868 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 182082001869 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 182082001870 ADP binding site [chemical binding]; other site 182082001871 phosphagen binding site; other site 182082001872 substrate specificity loop; other site 182082001873 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 182082001874 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 182082001875 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 182082001876 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 182082001877 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 182082001878 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 182082001879 Catalytic domain of Protein Kinases; Region: PKc; cd00180 182082001880 active site 182082001881 ATP binding site [chemical binding]; other site 182082001882 substrate binding site [chemical binding]; other site 182082001883 activation loop (A-loop); other site 182082001884 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 182082001885 type III secretion system protein; Validated; Region: PRK05933 182082001886 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 182082001887 type III secretion system ATPase; Provisional; Region: PRK06315 182082001888 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 182082001889 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 182082001890 Walker A motif/ATP binding site; other site 182082001891 Walker B motif; other site 182082001892 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 182082001893 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 182082001894 phosphopeptide binding site; other site 182082001895 AF-4 proto-oncoprotein; Region: AF-4; pfam05110 182082001896 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 182082001897 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 182082001898 phosphopeptide binding site; other site 182082001899 bacterial OsmY and nodulation domain; Region: BON; smart00749 182082001900 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 182082001901 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 182082001902 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 182082001903 NAD(P) binding pocket [chemical binding]; other site 182082001904 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 182082001905 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 182082001906 ATP binding site [chemical binding]; other site 182082001907 Mg2+ binding site [ion binding]; other site 182082001908 G-X-G motif; other site 182082001909 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 182082001910 anchoring element; other site 182082001911 dimer interface [polypeptide binding]; other site 182082001912 ATP binding site [chemical binding]; other site 182082001913 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 182082001914 active site 182082001915 putative metal-binding site [ion binding]; other site 182082001916 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 182082001917 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 182082001918 CAP-like domain; other site 182082001919 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 182082001920 active site 182082001921 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 182082001922 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 182082001923 RNA binding surface [nucleotide binding]; other site 182082001924 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 182082001925 active site 182082001926 hypothetical protein; Provisional; Region: PRK01064 182082001927 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 182082001928 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 182082001929 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 182082001930 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 182082001931 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 182082001932 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 182082001933 Walker A/P-loop; other site 182082001934 ATP binding site [chemical binding]; other site 182082001935 Q-loop/lid; other site 182082001936 ABC transporter signature motif; other site 182082001937 Walker B; other site 182082001938 D-loop; other site 182082001939 H-loop/switch region; other site 182082001940 6-phosphogluconate dehydrogenase; Provisional; Region: PTZ00142 182082001941 Effector from type III secretion system; Region: Effector_1; pfam04518 182082001942 Effector from type III secretion system; Region: Effector_1; pfam04518 182082001943 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 182082001944 MviN-like protein; Region: MVIN; pfam03023 182082001945 AP endonuclease family 2; Region: AP2Ec; smart00518 182082001946 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 182082001947 AP (apurinic/apyrimidinic) site pocket; other site 182082001948 DNA interaction; other site 182082001949 Metal-binding active site; metal-binding site 182082001950 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 182082001951 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 182082001952 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 182082001953 RNA binding surface [nucleotide binding]; other site 182082001954 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 182082001955 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 182082001956 active site residue [active] 182082001957 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 182082001958 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 182082001959 ATP-binding site [chemical binding]; other site 182082001960 Sugar specificity; other site 182082001961 Pyrimidine base specificity; other site 182082001962 H+ Antiporter protein; Region: 2A0121; TIGR00900 182082001963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 182082001964 putative substrate translocation pore; other site 182082001965 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 182082001966 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 182082001967 Family description; Region: UvrD_C_2; pfam13538 182082001968 rod shape-determining protein MreC; Provisional; Region: PRK14872 182082001969 rod shape-determining protein MreC; Region: MreC; pfam04085 182082001970 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 182082001971 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 182082001972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 182082001973 homodimer interface [polypeptide binding]; other site 182082001974 catalytic residue [active] 182082001975 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 182082001976 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 182082001977 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 182082001978 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA [Energy production and conversion]; Region: NqrA; COG1726 182082001979 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 182082001980 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 182082001981 dimer interface [polypeptide binding]; other site 182082001982 allosteric magnesium binding site [ion binding]; other site 182082001983 active site 182082001984 aspartate-rich active site metal binding site; other site 182082001985 Schiff base residues; other site 182082001986 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 182082001987 Thymidylate synthase complementing protein; Region: Thy1; cl03630 182082001988 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 182082001989 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 182082001990 substrate binding pocket [chemical binding]; other site 182082001991 chain length determination region; other site 182082001992 substrate-Mg2+ binding site; other site 182082001993 catalytic residues [active] 182082001994 aspartate-rich region 1; other site 182082001995 active site lid residues [active] 182082001996 aspartate-rich region 2; other site 182082001997 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 182082001998 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 182082001999 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 182082002000 DNA binding site [nucleotide binding] 182082002001 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 182082002002 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 182082002003 AAA domain; Region: AAA_30; pfam13604 182082002004 Family description; Region: UvrD_C_2; pfam13538 182082002005 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 182082002006 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 182082002007 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 182082002008 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 182082002009 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 182082002010 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 182082002011 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 182082002012 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 182082002013 DNA binding residues [nucleotide binding] 182082002014 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 182082002015 homooctamer interface [polypeptide binding]; other site 182082002016 active site 182082002017 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 182082002018 catalytic center binding site [active] 182082002019 ATP binding site [chemical binding]; other site 182082002020 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 182082002021 dihydropteroate synthase; Region: DHPS; TIGR01496 182082002022 substrate binding pocket [chemical binding]; other site 182082002023 dimer interface [polypeptide binding]; other site 182082002024 inhibitor binding site; inhibition site 182082002025 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 182082002026 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 182082002027 folate binding site [chemical binding]; other site 182082002028 NADP+ binding site [chemical binding]; other site 182082002029 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 182082002030 putative folate metabolism gamma-glutamate ligase; Region: intra_fol_E_lig; TIGR04132 182082002031 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 182082002032 recombinase A; Provisional; Region: recA; PRK09354 182082002033 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 182082002034 hexamer interface [polypeptide binding]; other site 182082002035 Walker A motif; other site 182082002036 ATP binding site [chemical binding]; other site 182082002037 Walker B motif; other site 182082002038 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 182082002039 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 182082002040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 182082002041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 182082002042 YGGT family; Region: YGGT; pfam02325 182082002043 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 182082002044 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 182082002045 FMN binding site [chemical binding]; other site 182082002046 active site 182082002047 catalytic residues [active] 182082002048 substrate binding site [chemical binding]; other site 182082002049 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 182082002050 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 182082002051 active site 182082002052 interdomain interaction site; other site 182082002053 putative metal-binding site [ion binding]; other site 182082002054 nucleotide binding site [chemical binding]; other site 182082002055 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 182082002056 domain I; other site 182082002057 DNA binding groove [nucleotide binding] 182082002058 phosphate binding site [ion binding]; other site 182082002059 domain II; other site 182082002060 domain III; other site 182082002061 nucleotide binding site [chemical binding]; other site 182082002062 catalytic site [active] 182082002063 domain IV; other site 182082002064 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 182082002065 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 182082002066 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 182082002067 SWIB/MDM2 domain; Region: SWIB; pfam02201 182082002068 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 182082002069 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 182082002070 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 182082002071 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 182082002072 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 182082002073 Part of AAA domain; Region: AAA_19; pfam13245 182082002074 Family description; Region: UvrD_C_2; pfam13538 182082002075 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 182082002076 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 182082002077 ligand binding site [chemical binding]; other site 182082002078 active site 182082002079 UGI interface [polypeptide binding]; other site 182082002080 catalytic site [active] 182082002081 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 182082002082 active site 182082002083 dimerization interface [polypeptide binding]; other site 182082002084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 182082002085 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 182082002086 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 182082002087 ring oligomerisation interface [polypeptide binding]; other site 182082002088 ATP/Mg binding site [chemical binding]; other site 182082002089 stacking interactions; other site 182082002090 hinge regions; other site 182082002091 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 182082002092 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 182082002093 dimer interface [polypeptide binding]; other site 182082002094 decamer (pentamer of dimers) interface [polypeptide binding]; other site 182082002095 catalytic triad [active] 182082002096 peroxidatic and resolving cysteines [active] 182082002097 Ependymin; Region: Ependymin; cl02428 182082002098 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 182082002099 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 182082002100 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 182082002101 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 182082002102 ligand binding site [chemical binding]; other site 182082002103 translocation protein TolB; Provisional; Region: tolB; PRK01029 182082002104 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 182082002105 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 182082002106 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 182082002107 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 182082002108 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 182082002109 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 182082002110 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 182082002111 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 182082002112 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 182082002113 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 182082002114 DsbD alpha interface [polypeptide binding]; other site 182082002115 catalytic residues [active] 182082002116 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 182082002117 active site 182082002118 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 182082002119 putative Iron-sulfur protein interface [polypeptide binding]; other site 182082002120 proximal heme binding site [chemical binding]; other site 182082002121 putative dimer interface [polypeptide binding]; other site 182082002122 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 182082002123 proximal heme binding site [chemical binding]; other site 182082002124 Iron-sulfur protein interface; other site 182082002125 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 182082002126 L-aspartate oxidase; Provisional; Region: PRK06175 182082002127 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 182082002128 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 182082002129 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 182082002130 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 182082002131 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 182082002132 HAMP domain; Region: HAMP; pfam00672 182082002133 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 182082002134 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 182082002135 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 182082002136 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 182082002137 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082002138 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 182082002139 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 182082002140 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 182082002141 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082002142 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 182082002143 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 182082002144 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 182082002145 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 182082002146 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 182082002147 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 182082002148 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 182082002149 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 182082002150 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 182082002151 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 182082002152 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 182082002153 enolase; Provisional; Region: eno; PRK00077 182082002154 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 182082002155 dimer interface [polypeptide binding]; other site 182082002156 metal binding site [ion binding]; metal-binding site 182082002157 substrate binding pocket [chemical binding]; other site 182082002158 excinuclease ABC subunit B; Provisional; Region: PRK05298 182082002159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 182082002160 ATP binding site [chemical binding]; other site 182082002161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 182082002162 nucleotide binding region [chemical binding]; other site 182082002163 ATP-binding site [chemical binding]; other site 182082002164 Ultra-violet resistance protein B; Region: UvrB; pfam12344 182082002165 UvrB/uvrC motif; Region: UVR; pfam02151 182082002166 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 182082002167 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 182082002168 active site 182082002169 HIGH motif; other site 182082002170 dimer interface [polypeptide binding]; other site 182082002171 KMSKS motif; other site 182082002172 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 182082002173 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 182082002174 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 182082002175 P-loop; other site 182082002176 Magnesium ion binding site [ion binding]; other site 182082002177 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 182082002178 Magnesium ion binding site [ion binding]; other site 182082002179 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 182082002180 TGS domain; Region: TGS; pfam02824 182082002181 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 182082002182 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 182082002183 active site 182082002184 dimer interface [polypeptide binding]; other site 182082002185 motif 1; other site 182082002186 motif 2; other site 182082002187 motif 3; other site 182082002188 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 182082002189 anticodon binding site; other site 182082002190 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 182082002191 EamA-like transporter family; Region: EamA; pfam00892 182082002192 EamA-like transporter family; Region: EamA; pfam00892 182082002193 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 182082002194 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 182082002195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 182082002196 binding surface 182082002197 TPR motif; other site 182082002198 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 182082002199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 182082002200 ATP binding site [chemical binding]; other site 182082002201 Mg2+ binding site [ion binding]; other site 182082002202 G-X-G motif; other site 182082002203 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 182082002204 ATP binding site [chemical binding]; other site 182082002205 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 182082002206 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 182082002207 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 182082002208 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 182082002209 active site 182082002210 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 182082002211 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 182082002212 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 182082002213 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 182082002214 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 182082002215 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 182082002216 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 182082002217 Walker A motif; other site 182082002218 ATP binding site [chemical binding]; other site 182082002219 Walker B motif; other site 182082002220 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 182082002221 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 182082002222 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 182082002223 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 182082002224 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 182082002225 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 182082002226 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 182082002227 FliP family; Region: FliP; cl00593 182082002228 type III secretion system protein; Reviewed; Region: PRK09617 182082002229 type III secretion system protein; Validated; Region: PRK06328 182082002230 Flagellar assembly protein FliH; Region: FliH; pfam02108 182082002231 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 182082002232 Lipoate synthase [Coenzyme metabolism]; Region: LipA; COG0320 182082002233 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 182082002234 FeS/SAM binding site; other site 182082002235 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 182082002236 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 182082002237 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 182082002238 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 182082002239 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 182082002240 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 182082002241 ATP binding site [chemical binding]; other site 182082002242 putative Mg++ binding site [ion binding]; other site 182082002243 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 182082002244 nucleotide binding region [chemical binding]; other site 182082002245 ATP-binding site [chemical binding]; other site 182082002246 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 182082002247 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 182082002248 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 182082002249 minor groove reading motif; other site 182082002250 helix-hairpin-helix signature motif; other site 182082002251 substrate binding pocket [chemical binding]; other site 182082002252 active site 182082002253 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 182082002254 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 182082002255 trmE is a tRNA modification GTPase; Region: trmE; cd04164 182082002256 G1 box; other site 182082002257 GTP/Mg2+ binding site [chemical binding]; other site 182082002258 Switch I region; other site 182082002259 G2 box; other site 182082002260 Switch II region; other site 182082002261 G3 box; other site 182082002262 G4 box; other site 182082002263 G5 box; other site 182082002264 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 182082002265 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 182082002266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 182082002267 TPR motif; other site 182082002268 binding surface 182082002269 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 182082002270 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 182082002271 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 182082002272 nucleotide binding region [chemical binding]; other site 182082002273 ATP-binding site [chemical binding]; other site 182082002274 Predicted GTPases [General function prediction only]; Region: COG1160 182082002275 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 182082002276 G1 box; other site 182082002277 GTP/Mg2+ binding site [chemical binding]; other site 182082002278 Switch I region; other site 182082002279 G2 box; other site 182082002280 Switch II region; other site 182082002281 G3 box; other site 182082002282 G4 box; other site 182082002283 G5 box; other site 182082002284 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 182082002285 G1 box; other site 182082002286 GTP/Mg2+ binding site [chemical binding]; other site 182082002287 Switch I region; other site 182082002288 G2 box; other site 182082002289 G3 box; other site 182082002290 Switch II region; other site 182082002291 G4 box; other site 182082002292 G5 box; other site 182082002293 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 182082002294 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 182082002295 active site 182082002296 NTP binding site [chemical binding]; other site 182082002297 metal binding triad [ion binding]; metal-binding site 182082002298 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 182082002299 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 182082002300 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 182082002301 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 182082002302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 182082002303 Walker A motif; other site 182082002304 ATP binding site [chemical binding]; other site 182082002305 Walker B motif; other site 182082002306 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 182082002307 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 182082002308 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 182082002309 oligomer interface [polypeptide binding]; other site 182082002310 active site residues [active] 182082002311 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 182082002312 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 182082002313 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 182082002314 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 182082002315 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 182082002316 ATP binding site [chemical binding]; other site 182082002317 putative Mg++ binding site [ion binding]; other site 182082002318 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 182082002319 nucleotide binding region [chemical binding]; other site 182082002320 ATP-binding site [chemical binding]; other site 182082002321 rod shape-determining protein MreB; Provisional; Region: PRK13927 182082002322 MreB and similar proteins; Region: MreB_like; cd10225 182082002323 nucleotide binding site [chemical binding]; other site 182082002324 Mg binding site [ion binding]; other site 182082002325 putative protofilament interaction site [polypeptide binding]; other site 182082002326 RodZ interaction site [polypeptide binding]; other site 182082002327 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 182082002328 active site 182082002329 substrate-binding site [chemical binding]; other site 182082002330 metal-binding site [ion binding] 182082002331 GTP binding site [chemical binding]; other site 182082002332 Effector from type III secretion system; Region: Effector_1; pfam04518 182082002333 Effector from type III secretion system; Region: Effector_1; pfam04518 182082002334 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 182082002335 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 182082002336 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 182082002337 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 182082002338 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 182082002339 substrate binding site; other site 182082002340 dimerization interface; other site 182082002341 type III secretion system ATPase; Validated; Region: PRK05922 182082002342 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 182082002343 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 182082002344 Walker A motif/ATP binding site; other site 182082002345 Walker B motif; other site 182082002346 Flagellar assembly protein FliH; Region: FliH; pfam02108 182082002347 type III secretion system protein; Validated; Region: PRK05934 182082002348 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 182082002349 MgtE intracellular N domain; Region: MgtE_N; cl15244 182082002350 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 182082002351 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 182082002352 trimerization site [polypeptide binding]; other site 182082002353 active site 182082002354 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 182082002355 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 182082002356 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 182082002357 catalytic residue [active] 182082002358 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 182082002359 catalytic core [active] 182082002360 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 182082002361 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 182082002362 RNA binding surface [nucleotide binding]; other site 182082002363 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 182082002364 active site 182082002365 biotin--protein ligase; Provisional; Region: PRK05935 182082002366 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 182082002367 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 182082002368 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 182082002369 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 182082002370 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 182082002371 motif II; other site 182082002372 CCC1-related protein family; Region: CCC1_like_1; cd02437 182082002373 seryl-tRNA synthetase; Provisional; Region: PRK05431 182082002374 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 182082002375 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 182082002376 dimer interface [polypeptide binding]; other site 182082002377 active site 182082002378 motif 1; other site 182082002379 motif 2; other site 182082002380 motif 3; other site 182082002381 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 182082002382 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 182082002383 catalytic motif [active] 182082002384 Zn binding site [ion binding]; other site 182082002385 RibD C-terminal domain; Region: RibD_C; cl17279 182082002386 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 182082002387 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 182082002388 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 182082002389 dimerization interface [polypeptide binding]; other site 182082002390 active site 182082002391 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 182082002392 homopentamer interface [polypeptide binding]; other site 182082002393 active site 182082002394 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 182082002395 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 182082002396 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 182082002397 substrate binding site [chemical binding]; other site 182082002398 Proteins containing SET domain [General function prediction only]; Region: COG2940 182082002399 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 182082002400 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 182082002401 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 182082002402 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 182082002403 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 182082002404 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 182082002405 Protein of unknown function (DUF687); Region: DUF687; pfam05095 182082002406 Protein of unknown function (DUF687); Region: DUF687; pfam05095 182082002407 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 182082002408 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 182082002409 catalytic loop [active] 182082002410 iron binding site [ion binding]; other site 182082002411 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 182082002412 FAD binding pocket [chemical binding]; other site 182082002413 FAD binding motif [chemical binding]; other site 182082002414 phosphate binding motif [ion binding]; other site 182082002415 beta-alpha-beta structure motif; other site 182082002416 NAD binding pocket [chemical binding]; other site 182082002417 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 182082002418 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 182082002419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 182082002420 S-adenosylmethionine binding site [chemical binding]; other site 182082002421 Histone H1-like protein Hc1; Region: Hc1; pfam07432 182082002422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 182082002423 binding surface 182082002424 TPR motif; other site 182082002425 Tetratricopeptide repeat; Region: TPR_12; pfam13424 182082002426 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 182082002427 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 182082002428 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 182082002429 HemN C-terminal domain; Region: HemN_C; pfam06969 182082002430 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 182082002431 substrate binding site [chemical binding]; other site 182082002432 active site 182082002433 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 182082002434 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 182082002435 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 182082002436 ATP binding site [chemical binding]; other site 182082002437 putative Mg++ binding site [ion binding]; other site 182082002438 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 182082002439 nucleotide binding region [chemical binding]; other site 182082002440 ATP-binding site [chemical binding]; other site 182082002441 TRCF domain; Region: TRCF; pfam03461 182082002442 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 182082002443 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 182082002444 motif 1; other site 182082002445 active site 182082002446 motif 2; other site 182082002447 motif 3; other site 182082002448 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 182082002449 DHHA1 domain; Region: DHHA1; pfam02272 182082002450 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 182082002451 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 182082002452 TPP-binding site [chemical binding]; other site 182082002453 dimer interface [polypeptide binding]; other site 182082002454 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 182082002455 PYR/PP interface [polypeptide binding]; other site 182082002456 dimer interface [polypeptide binding]; other site 182082002457 TPP binding site [chemical binding]; other site 182082002458 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 182082002459 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 182082002460 elongation factor P; Validated; Region: PRK00529 182082002461 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 182082002462 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 182082002463 RNA binding site [nucleotide binding]; other site 182082002464 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 182082002465 RNA binding site [nucleotide binding]; other site 182082002466 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 182082002467 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 182082002468 putative active site [active] 182082002469 putative metal binding site [ion binding]; other site 182082002470 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 182082002471 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 182082002472 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 182082002473 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 182082002474 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 182082002475 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 182082002476 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 182082002477 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 182082002478 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 182082002479 Mg++ binding site [ion binding]; other site 182082002480 putative catalytic motif [active] 182082002481 putative substrate binding site [chemical binding]; other site 182082002482 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 182082002483 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 182082002484 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 182082002485 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 182082002486 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 182082002487 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 182082002488 cell division protein FtsW; Region: ftsW; TIGR02614 182082002489 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 182082002490 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 182082002491 active site 182082002492 homodimer interface [polypeptide binding]; other site 182082002493 bifunctional D-alanyl-alanine synthetase A/UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: PRK14573 182082002494 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 182082002495 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 182082002496 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 182082002497 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 182082002498 ATP-grasp domain; Region: ATP-grasp_4; cl17255 182082002499 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 182082002500 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409 182082002501 G-X-X-G motif; other site 182082002502 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 182082002503 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 182082002504 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 182082002505 anti sigma factor interaction site; other site 182082002506 regulatory phosphorylation site [posttranslational modification]; other site 182082002507 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 182082002508 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 182082002509 hypothetical protein; Provisional; Region: PRK05927 182082002510 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 182082002511 FeS/SAM binding site; other site 182082002512 Cytochrome c552; Region: Cytochrom_C552; pfam02335 182082002513 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 182082002514 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 182082002515 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 182082002516 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 182082002517 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 182082002518 dimer interface [polypeptide binding]; other site 182082002519 active site 182082002520 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 182082002521 active site 182082002522 Ap4A binding cleft/pocket [chemical binding]; other site 182082002523 P4 phosphate binding site; other site 182082002524 nudix motif; other site 182082002525 putative P2/P3 phosphate binding site [ion binding]; other site 182082002526 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 182082002527 dimer interface [polypeptide binding]; other site 182082002528 substrate binding site [chemical binding]; other site 182082002529 metal binding sites [ion binding]; metal-binding site 182082002530 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 182082002531 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 182082002532 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 182082002533 NAD binding site [chemical binding]; other site 182082002534 Phe binding site; other site 182082002535 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 182082002536 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 182082002537 active site 182082002538 putative lithium-binding site [ion binding]; other site 182082002539 substrate binding site [chemical binding]; other site 182082002540 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 182082002541 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 182082002542 putative acyl-acceptor binding pocket; other site 182082002543 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 182082002544 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 182082002545 acyl-activating enzyme (AAE) consensus motif; other site 182082002546 putative AMP binding site [chemical binding]; other site 182082002547 8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937 182082002548 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 182082002549 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 182082002550 catalytic residue [active] 182082002551 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 182082002552 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 182082002553 ATP binding site [chemical binding]; other site 182082002554 putative Mg++ binding site [ion binding]; other site 182082002555 helicase superfamily c-terminal domain; Region: HELICc; smart00490 182082002556 ATP-binding site [chemical binding]; other site 182082002557 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 182082002558 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 182082002559 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 182082002560 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 182082002561 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 182082002562 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 182082002563 Lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: LysU; COG1190 182082002564 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 182082002565 dimer interface [polypeptide binding]; other site 182082002566 putative anticodon binding site; other site 182082002567 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 182082002568 motif 1; other site 182082002569 dimer interface [polypeptide binding]; other site 182082002570 active site 182082002571 motif 2; other site 182082002572 motif 3; other site 182082002573 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 182082002574 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 182082002575 active site 182082002576 HIGH motif; other site 182082002577 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 182082002578 KMSKS motif; other site 182082002579 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 182082002580 anticodon binding site; other site 182082002581 tRNA binding surface [nucleotide binding]; other site 182082002582 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 182082002583 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 182082002584 ribonuclease P; Reviewed; Region: rnpA; PRK00730 182082002585 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 182082002586 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 182082002587 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 182082002588 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 182082002589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 182082002590 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 182082002591 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 182082002592 GIY-YIG motif/motif A; other site 182082002593 active site 182082002594 catalytic site [active] 182082002595 putative DNA binding site [nucleotide binding]; other site 182082002596 metal binding site [ion binding]; metal-binding site 182082002597 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 182082002598 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 182082002599 MutS domain I; Region: MutS_I; pfam01624 182082002600 MutS domain II; Region: MutS_II; pfam05188 182082002601 MutS domain III; Region: MutS_III; pfam05192 182082002602 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 182082002603 Walker A/P-loop; other site 182082002604 ATP binding site [chemical binding]; other site 182082002605 Q-loop/lid; other site 182082002606 ABC transporter signature motif; other site 182082002607 Walker B; other site 182082002608 D-loop; other site 182082002609 H-loop/switch region; other site 182082002610 DNA primase; Validated; Region: dnaG; PRK05667 182082002611 CHC2 zinc finger; Region: zf-CHC2; pfam01807 182082002612 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 182082002613 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 182082002614 active site 182082002615 metal binding site [ion binding]; metal-binding site 182082002616 interdomain interaction site; other site 182082002617 glycyl-tRNA synthetase; Provisional; Region: PRK14908 182082002618 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 182082002619 dimer interface [polypeptide binding]; other site 182082002620 motif 1; other site 182082002621 active site 182082002622 motif 2; other site 182082002623 motif 3; other site 182082002624 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 182082002625 glycogen synthase; Provisional; Region: glgA; PRK00654 182082002626 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 182082002627 ADP-binding pocket [chemical binding]; other site 182082002628 homodimer interface [polypeptide binding]; other site 182082002629 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 182082002630 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 182082002631 5S rRNA interface [nucleotide binding]; other site 182082002632 CTC domain interface [polypeptide binding]; other site 182082002633 L16 interface [polypeptide binding]; other site 182082002634 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 182082002635 putative active site [active] 182082002636 catalytic residue [active] 182082002637 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 182082002638 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 182082002639 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 182082002640 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 182082002641 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 182082002642 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 182082002643 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK00650 182082002644 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 182082002645 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 182082002646 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 182082002647 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 182082002648 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 182082002649 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT; Region: LPLAT_GPAT; cd07985 182082002650 putative G3P-binding pocket; other site 182082002651 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 182082002652 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 182082002653 homodimer interface [polypeptide binding]; other site 182082002654 oligonucleotide binding site [chemical binding]; other site 182082002655 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 182082002656 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 182082002657 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 182082002658 Autotransporter beta-domain; Region: Autotransporter; pfam03797 182082002659 Domain of Unknown Function (DUF1539); Region: DUF1539; pfam07560 182082002660 Domain of Unknown Function (DUF1548); Region: DUF1548; pfam07579 182082002661 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 182082002662 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 182082002663 Predicted membrane protein [Function unknown]; Region: COG3952 182082002664 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 182082002665 poly(A) polymerase; Region: pcnB; TIGR01942 182082002666 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 182082002667 active site 182082002668 NTP binding site [chemical binding]; other site 182082002669 metal binding triad [ion binding]; metal-binding site 182082002670 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 182082002671 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 182082002672 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 182082002673 active site 182082002674 substrate binding site [chemical binding]; other site 182082002675 metal binding site [ion binding]; metal-binding site 182082002676 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 182082002677 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 182082002678 glutaminase active site [active] 182082002679 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 182082002680 dimer interface [polypeptide binding]; other site 182082002681 active site 182082002682 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 182082002683 dimer interface [polypeptide binding]; other site 182082002684 active site 182082002685 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 182082002686 aromatic amino acid transport protein; Region: araaP; TIGR00837 182082002687 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 182082002688 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 182082002689 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 182082002690 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 182082002691 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 182082002692 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 182082002693 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 182082002694 CoA-ligase; Region: Ligase_CoA; pfam00549 182082002695 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 182082002696 CoA binding domain; Region: CoA_binding; smart00881 182082002697 CoA-ligase; Region: Ligase_CoA; pfam00549 182082002698 Family of unknown function (DUF648); Region: DUF648; pfam04890 182082002699 Family of unknown function (DUF648); Region: DUF648; pfam04890 182082002700 Family of unknown function (DUF648); Region: DUF648; pfam04890 182082002701 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 182082002702 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 182082002703 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 182082002704 protein binding site [polypeptide binding]; other site 182082002705 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 182082002706 protein binding site [polypeptide binding]; other site 182082002707 hypothetical protein; Provisional; Region: PRK08201 182082002708 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 182082002709 metal binding site [ion binding]; metal-binding site 182082002710 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 182082002711 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 182082002712 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 182082002713 Peptidase M16C associated; Region: M16C_assoc; pfam08367 182082002714 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 182082002715 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 182082002716 RmuC family; Region: RmuC; pfam02646 182082002717 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 182082002718 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 182082002719 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 182082002720 ATP cone domain; Region: ATP-cone; pfam03477 182082002721 ATP cone domain; Region: ATP-cone; pfam03477 182082002722 Class I ribonucleotide reductase; Region: RNR_I; cd01679 182082002723 active site 182082002724 dimer interface [polypeptide binding]; other site 182082002725 catalytic residues [active] 182082002726 effector binding site; other site 182082002727 R2 peptide binding site; other site 182082002728 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 182082002729 dimer interface [polypeptide binding]; other site 182082002730 putative radical transfer pathway; other site 182082002731 diiron center [ion binding]; other site 182082002732 tyrosyl radical; other site 182082002733 Putative methyltransferase; Region: Methyltransf_4; pfam02390 182082002734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 182082002735 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 182082002736 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 182082002737 FAD binding domain; Region: FAD_binding_4; pfam01565 182082002738 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 182082002739 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 182082002740 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 182082002741 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 182082002742 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 182082002743 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 182082002744 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 182082002745 23S rRNA binding site [nucleotide binding]; other site 182082002746 L21 binding site [polypeptide binding]; other site 182082002747 L13 binding site [polypeptide binding]; other site 182082002748 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 182082002749 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 182082002750 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 182082002751 dimer interface [polypeptide binding]; other site 182082002752 motif 1; other site 182082002753 active site 182082002754 motif 2; other site 182082002755 motif 3; other site 182082002756 Predicted permeases [General function prediction only]; Region: COG0795 182082002757 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 182082002758 Predicted permeases [General function prediction only]; Region: COG0795 182082002759 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 182082002760 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 182082002761 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 182082002762 Ligand Binding Site [chemical binding]; other site 182082002763 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 182082002764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 182082002765 Walker A motif; other site 182082002766 ATP binding site [chemical binding]; other site 182082002767 Walker B motif; other site 182082002768 arginine finger; other site 182082002769 Peptidase family M41; Region: Peptidase_M41; pfam01434 182082002770 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 182082002771 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 182082002772 oligomer interface [polypeptide binding]; other site 182082002773 RNA binding site [nucleotide binding]; other site 182082002774 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 182082002775 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 182082002776 RNase E interface [polypeptide binding]; other site 182082002777 trimer interface [polypeptide binding]; other site 182082002778 active site 182082002779 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 182082002780 putative nucleic acid binding region [nucleotide binding]; other site 182082002781 G-X-X-G motif; other site 182082002782 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 182082002783 RNA binding site [nucleotide binding]; other site 182082002784 domain interface; other site 182082002785 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 182082002786 16S/18S rRNA binding site [nucleotide binding]; other site 182082002787 S13e-L30e interaction site [polypeptide binding]; other site 182082002788 25S rRNA binding site [nucleotide binding]; other site 182082002789 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 182082002790 nucleoside/Zn binding site; other site 182082002791 dimer interface [polypeptide binding]; other site 182082002792 catalytic motif [active] 182082002793 Protein of unknown function (DUF720); Region: DUF720; pfam05302 182082002794 Protein of unknown function (DUF720); Region: DUF720; pfam05302 182082002795 Protein of unknown function (DUF720); Region: DUF720; pfam05302 182082002796 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 182082002797 methionine aminopeptidase; Provisional; Region: PRK12318 182082002798 SEC-C motif; Region: SEC-C; pfam02810 182082002799 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 182082002800 active site 182082002801 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 182082002802 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 182082002803 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 182082002804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 182082002805 dimer interface [polypeptide binding]; other site 182082002806 conserved gate region; other site 182082002807 putative PBP binding loops; other site 182082002808 ABC-ATPase subunit interface; other site 182082002809 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 182082002810 NMT1/THI5 like; Region: NMT1; pfam09084 182082002811 fumarate hydratase, class II; Region: fumC_II; TIGR00979 182082002812 Class II fumarases; Region: Fumarase_classII; cd01362 182082002813 active site 182082002814 tetramer interface [polypeptide binding]; other site 182082002815 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 182082002816 Sulfate transporter family; Region: Sulfate_transp; pfam00916 182082002817 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 182082002818 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 182082002819 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 182082002820 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 182082002821 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 182082002822 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 182082002823 active site triad [active] 182082002824 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 182082002825 LytB protein; Region: LYTB; pfam02401 182082002826 Histone methylation protein DOT1; Region: DOT1; pfam08123 182082002827 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 182082002828 Tetratricopeptide repeat; Region: TPR_3; pfam07720 182082002829 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 182082002830 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 182082002831 active site 182082002832 Int/Topo IB signature motif; other site 182082002833 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 182082002834 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 182082002835 active site 182082002836 dimer interface [polypeptide binding]; other site 182082002837 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 182082002838 dimer interface [polypeptide binding]; other site 182082002839 active site 182082002840 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 182082002841 malate dehydrogenase; Provisional; Region: PRK05442 182082002842 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 182082002843 NAD(P) binding site [chemical binding]; other site 182082002844 dimer interface [polypeptide binding]; other site 182082002845 malate binding site [chemical binding]; other site 182082002846 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 182082002847 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 182082002848 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 182082002849 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 182082002850 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 182082002851 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 182082002852 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 182082002853 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 182082002854 active site 182082002855 catalytic residue [active] 182082002856 dimer interface [polypeptide binding]; other site 182082002857 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 182082002858 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 182082002859 shikimate binding site; other site 182082002860 NAD(P) binding site [chemical binding]; other site 182082002861 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 182082002862 active site 182082002863 dimer interface [polypeptide binding]; other site 182082002864 metal binding site [ion binding]; metal-binding site 182082002865 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 182082002866 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 182082002867 Tetramer interface [polypeptide binding]; other site 182082002868 active site 182082002869 FMN-binding site [chemical binding]; other site 182082002870 shikimate kinase; Provisional; Region: PRK00625 182082002871 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 182082002872 ADP binding site [chemical binding]; other site 182082002873 magnesium binding site [ion binding]; other site 182082002874 putative shikimate binding site; other site 182082002875 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 182082002876 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 182082002877 hinge; other site 182082002878 active site 182082002879 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 182082002880 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 182082002881 inhibitor-cofactor binding pocket; inhibition site 182082002882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 182082002883 catalytic residue [active] 182082002884 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 182082002885 AAA domain; Region: AAA_26; pfam13500 182082002886 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 182082002887 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 182082002888 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 182082002889 catalytic residue [active] 182082002890 Biotin synthase and related enzymes [Coenzyme metabolism]; Region: BioB; COG0502 182082002891 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 182082002892 FeS/SAM binding site; other site 182082002893 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 182082002894 conserved hypothetical integral membrane protein; Region: TIGR00697 182082002895 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 182082002896 cofactor binding site; other site 182082002897 metal binding site [ion binding]; metal-binding site 182082002898 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 182082002899 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 182082002900 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 182082002901 aspartate-semialdehyde dehydrogenase (non-peptidoglycan organisms); Region: asd_EA; TIGR00978 182082002902 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 182082002903 aspartate kinase; Provisional; Region: PRK05925 182082002904 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 182082002905 putative catalytic residues [active] 182082002906 nucleotide binding site [chemical binding]; other site 182082002907 aspartate binding site [chemical binding]; other site 182082002908 dihydrodipicolinate synthase; Provisional; Region: PRK03170 182082002909 dihydrodipicolinate synthase; Region: dapA; TIGR00674 182082002910 catalytic residue [active] 182082002911 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 182082002912 IncA protein; Region: IncA; pfam04156 182082002913 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 182082002914 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 182082002915 catalytic residues [active] 182082002916 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 182082002917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 182082002918 S-adenosylmethionine binding site [chemical binding]; other site 182082002919 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 182082002920 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 182082002921 TPP-binding site; other site 182082002922 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 182082002923 PYR/PP interface [polypeptide binding]; other site 182082002924 dimer interface [polypeptide binding]; other site 182082002925 TPP binding site [chemical binding]; other site 182082002926 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 182082002927 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 182082002928 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 182082002929 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 182082002930 generic binding surface II; other site 182082002931 generic binding surface I; other site 182082002932 triosephosphate isomerase; Provisional; Region: PRK14567 182082002933 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 182082002934 substrate binding site [chemical binding]; other site 182082002935 dimer interface [polypeptide binding]; other site 182082002936 catalytic triad [active] 182082002937 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 182082002938 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 182082002939 active site 182082002940 catalytic residues [active] 182082002941 metal binding site [ion binding]; metal-binding site 182082002942 ribonuclease HIII; Provisional; Region: PRK00996 182082002943 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 182082002944 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 182082002945 RNA/DNA hybrid binding site [nucleotide binding]; other site 182082002946 active site 182082002947 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 182082002948 Helix-turn-helix domain; Region: HTH_25; pfam13413 182082002949 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 182082002950 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019