-- dump date 20140619_040451 -- class Genbank::misc_feature -- table misc_feature_note -- id note 138677000001 Uncharacterized conserved protein [Function unknown]; Region: COG2155 138677000002 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 138677000003 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 138677000004 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 138677000005 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 138677000006 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 138677000007 GatB domain; Region: GatB_Yqey; pfam02637 138677000008 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677000009 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677000010 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 138677000011 IncA protein; Region: IncA; pfam04156 138677000012 IncA protein; Region: IncA; pfam04156 138677000013 Domain of unknown function (DUF1978); Region: DUF1978; pfam09321 138677000014 IncA protein; Region: IncA; pfam04156 138677000015 Domain of unknown function (DUF1978); Region: DUF1978; pfam09321 138677000016 Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253 138677000017 IncA protein; Region: IncA; pfam04156 138677000018 Domain of unknown function (DUF1978); Region: DUF1978; pfam09321 138677000019 IncA protein; Region: IncA; pfam04156 138677000020 Domain of unknown function (DUF1978); Region: DUF1978; pfam09321 138677000021 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 138677000022 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677000023 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677000024 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677000025 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677000026 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677000027 adhesin; Provisional; Region: PRK09752 138677000028 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677000029 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677000030 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677000031 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677000032 Autotransporter beta-domain; Region: Autotransporter; smart00869 138677000033 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 138677000034 Maf-like protein; Region: Maf; pfam02545 138677000035 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 138677000036 active site 138677000037 dimer interface [polypeptide binding]; other site 138677000038 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 138677000039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 138677000040 Walker A/P-loop; other site 138677000041 ATP binding site [chemical binding]; other site 138677000042 Q-loop/lid; other site 138677000043 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 138677000044 ABC transporter; Region: ABC_tran_2; pfam12848 138677000045 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 138677000046 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 138677000047 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 138677000048 active site 138677000049 Int/Topo IB signature motif; other site 138677000050 ribonuclease Z; Region: RNase_Z; TIGR02651 138677000051 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 138677000052 Found in ATP-dependent protease La (LON); Region: LON; smart00464 138677000053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 138677000054 Walker A motif; other site 138677000055 ATP binding site [chemical binding]; other site 138677000056 Walker B motif; other site 138677000057 arginine finger; other site 138677000058 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 138677000059 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 138677000060 Glycoprotease family; Region: Peptidase_M22; pfam00814 138677000061 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 138677000062 chaperone protein DnaJ; Provisional; Region: PRK14284 138677000063 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 138677000064 HSP70 interaction site [polypeptide binding]; other site 138677000065 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 138677000066 Zn binding sites [ion binding]; other site 138677000067 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 138677000068 dimer interface [polypeptide binding]; other site 138677000069 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 138677000070 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 138677000071 tetramer interface [polypeptide binding]; other site 138677000072 TPP-binding site [chemical binding]; other site 138677000073 heterodimer interface [polypeptide binding]; other site 138677000074 phosphorylation loop region [posttranslational modification] 138677000075 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 138677000076 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 138677000077 alpha subunit interface [polypeptide binding]; other site 138677000078 TPP binding site [chemical binding]; other site 138677000079 heterodimer interface [polypeptide binding]; other site 138677000080 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 138677000081 Appr-1"-p processing enzyme; Region: A1pp; smart00506 138677000082 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 138677000083 Competence protein; Region: Competence; pfam03772 138677000084 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 138677000085 dimerization domain swap beta strand [polypeptide binding]; other site 138677000086 regulatory protein interface [polypeptide binding]; other site 138677000087 active site 138677000088 regulatory phosphorylation site [posttranslational modification]; other site 138677000089 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 138677000090 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 138677000091 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 138677000092 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 138677000093 hypothetical protein; Validated; Region: PRK00153 138677000094 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 138677000095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 138677000096 Walker A motif; other site 138677000097 ATP binding site [chemical binding]; other site 138677000098 Walker B motif; other site 138677000099 arginine finger; other site 138677000100 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 138677000101 IncA protein; Region: IncA; pfam04156 138677000102 Domain of unknown function (DUF1978); Region: DUF1978; pfam09321 138677000103 transferase, transferring glycosyl groups; Region: PLN02939 138677000104 Domain of unknown function (DUF1978); Region: DUF1978; pfam09321 138677000105 IncA protein; Region: IncA; pfam04156 138677000106 Domain of unknown function (DUF1978); Region: DUF1978; pfam09321 138677000107 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 138677000108 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 138677000109 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 138677000110 Zn2+ binding site [ion binding]; other site 138677000111 Mg2+ binding site [ion binding]; other site 138677000112 porphobilinogen deaminase; Provisional; Region: PRK01066 138677000113 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 138677000114 domain interfaces; other site 138677000115 active site 138677000116 DNA repair protein RadA; Provisional; Region: PRK11823 138677000117 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 138677000118 Walker A motif/ATP binding site; other site 138677000119 ATP binding site [chemical binding]; other site 138677000120 Walker B motif; other site 138677000121 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 138677000122 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 138677000123 dimerization interface [polypeptide binding]; other site 138677000124 active site 138677000125 metal binding site [ion binding]; metal-binding site 138677000126 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 138677000127 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 138677000128 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 138677000129 active site 138677000130 substrate binding site [chemical binding]; other site 138677000131 metal binding site [ion binding]; metal-binding site 138677000132 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 138677000133 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 138677000134 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 138677000135 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 138677000136 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 138677000137 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 138677000138 trimer interface [polypeptide binding]; other site 138677000139 active site 138677000140 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 138677000141 active site 138677000142 phosphorylation site [posttranslational modification] 138677000143 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 138677000144 DNA binding residues [nucleotide binding] 138677000145 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 138677000146 active site 138677000147 phosphorylation site [posttranslational modification] 138677000148 IncA protein; Region: IncA; pfam04156 138677000149 Protein of unknown function (DUF687); Region: DUF687; pfam05095 138677000150 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 138677000151 Protein of unknown function (DUF687); Region: DUF687; pfam05095 138677000152 Fe-S metabolism associated domain; Region: SufE; pfam02657 138677000153 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 138677000154 rRNA binding site [nucleotide binding]; other site 138677000155 predicted 30S ribosome binding site; other site 138677000156 elongation factor Tu; Reviewed; Region: PRK12735 138677000157 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 138677000158 G1 box; other site 138677000159 GEF interaction site [polypeptide binding]; other site 138677000160 GTP/Mg2+ binding site [chemical binding]; other site 138677000161 Switch I region; other site 138677000162 G2 box; other site 138677000163 G3 box; other site 138677000164 Switch II region; other site 138677000165 G4 box; other site 138677000166 G5 box; other site 138677000167 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 138677000168 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 138677000169 Antibiotic Binding Site [chemical binding]; other site 138677000170 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 138677000171 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 138677000172 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 138677000173 putative homodimer interface [polypeptide binding]; other site 138677000174 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 138677000175 heterodimer interface [polypeptide binding]; other site 138677000176 homodimer interface [polypeptide binding]; other site 138677000177 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 138677000178 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 138677000179 putative thiostrepton binding site; other site 138677000180 23S rRNA interface [nucleotide binding]; other site 138677000181 L7/L12 interface [polypeptide binding]; other site 138677000182 L25 interface [polypeptide binding]; other site 138677000183 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 138677000184 mRNA/rRNA interface [nucleotide binding]; other site 138677000185 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 138677000186 23S rRNA interface [nucleotide binding]; other site 138677000187 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 138677000188 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 138677000189 L11 interface [polypeptide binding]; other site 138677000190 putative EF-Tu interaction site [polypeptide binding]; other site 138677000191 putative EF-G interaction site [polypeptide binding]; other site 138677000192 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 138677000193 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 138677000194 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 138677000195 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 138677000196 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 138677000197 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 138677000198 RPB3 interaction site [polypeptide binding]; other site 138677000199 RPB1 interaction site [polypeptide binding]; other site 138677000200 RPB11 interaction site [polypeptide binding]; other site 138677000201 RPB10 interaction site [polypeptide binding]; other site 138677000202 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 138677000203 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 138677000204 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 138677000205 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 138677000206 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 138677000207 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 138677000208 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 138677000209 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 138677000210 DNA binding site [nucleotide binding] 138677000211 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 138677000212 transaldolase-like protein; Provisional; Region: PTZ00411 138677000213 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 138677000214 active site 138677000215 dimer interface [polypeptide binding]; other site 138677000216 catalytic residue [active] 138677000217 V-type ATP synthase subunit E; Provisional; Region: PRK01005 138677000218 V-type ATP synthase subunit E; Provisional; Region: PRK01558 138677000219 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 138677000220 V-type ATP synthase subunit A; Provisional; Region: PRK04192 138677000221 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 138677000222 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 138677000223 Walker A motif/ATP binding site; other site 138677000224 Walker B motif; other site 138677000225 V-type ATP synthase subunit B; Provisional; Region: PRK02118 138677000226 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 138677000227 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 138677000228 Walker A motif homologous position; other site 138677000229 Walker B motif; other site 138677000230 V-type ATP synthase subunit D; Provisional; Region: PRK02195 138677000231 Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269 138677000232 V-type ATP synthase subunit K; Provisional; Region: PRK09621 138677000233 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 138677000234 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 138677000235 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 138677000236 HIGH motif; other site 138677000237 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 138677000238 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 138677000239 active site 138677000240 KMSKS motif; other site 138677000241 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 138677000242 tRNA binding surface [nucleotide binding]; other site 138677000243 anticodon binding site; other site 138677000244 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 138677000245 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 138677000246 Catalytic domain of Protein Kinases; Region: PKc; cd00180 138677000247 active site 138677000248 ATP binding site [chemical binding]; other site 138677000249 substrate binding site [chemical binding]; other site 138677000250 activation loop (A-loop); other site 138677000251 excinuclease ABC subunit A; Provisional; Region: PRK00635 138677000252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 138677000253 Walker A/P-loop; other site 138677000254 ATP binding site [chemical binding]; other site 138677000255 Q-loop/lid; other site 138677000256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 138677000257 ABC transporter signature motif; other site 138677000258 Walker B; other site 138677000259 D-loop; other site 138677000260 H-loop/switch region; other site 138677000261 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 138677000262 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 138677000263 Walker A/P-loop; other site 138677000264 ATP binding site [chemical binding]; other site 138677000265 Q-loop/lid; other site 138677000266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 138677000267 Q-loop/lid; other site 138677000268 ABC transporter signature motif; other site 138677000269 Walker B; other site 138677000270 D-loop; other site 138677000271 H-loop/switch region; other site 138677000272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 138677000273 Walker A/P-loop; other site 138677000274 ATP binding site [chemical binding]; other site 138677000275 Q-loop/lid; other site 138677000276 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 138677000277 pyruvate kinase; Region: pyruv_kin; TIGR01064 138677000278 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 138677000279 domain interfaces; other site 138677000280 active site 138677000281 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 138677000282 putative acyl-acceptor binding pocket; other site 138677000283 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 138677000284 Uncharacterized conserved protein [Function unknown]; Region: COG1624 138677000285 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 138677000286 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 138677000287 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 138677000288 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 138677000289 Bacterial SH3 domain homologues; Region: SH3b; smart00287 138677000290 Bacterial SH3 domain homologues; Region: SH3b; smart00287 138677000291 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 138677000292 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 138677000293 putative active site [active] 138677000294 PhoH-like protein; Region: PhoH; pfam02562 138677000295 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 138677000296 ADP-ribose binding site [chemical binding]; other site 138677000297 Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several...; Region: IFab; cl00092 138677000298 N-glycosylation site [posttranslational modification]; other site 138677000299 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 138677000300 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 138677000301 HIGH motif; other site 138677000302 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 138677000303 active site 138677000304 KMSKS motif; other site 138677000305 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 138677000306 tRNA binding surface [nucleotide binding]; other site 138677000307 anticodon binding site; other site 138677000308 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 138677000309 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 138677000310 Catalytic site [active] 138677000311 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 138677000312 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 138677000313 peptide chain release factor 1; Validated; Region: prfA; PRK00591 138677000314 PCRF domain; Region: PCRF; pfam03462 138677000315 RF-1 domain; Region: RF-1; pfam00472 138677000316 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 138677000317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 138677000318 S-adenosylmethionine binding site [chemical binding]; other site 138677000319 signal recognition particle protein; Provisional; Region: PRK10867 138677000320 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 138677000321 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 138677000322 P loop; other site 138677000323 GTP binding site [chemical binding]; other site 138677000324 Signal peptide binding domain; Region: SRP_SPB; pfam02978 138677000325 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 138677000326 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 138677000327 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 138677000328 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 138677000329 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 138677000330 RNA/DNA hybrid binding site [nucleotide binding]; other site 138677000331 active site 138677000332 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 138677000333 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 138677000334 catalytic site [active] 138677000335 G-X2-G-X-G-K; other site 138677000336 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 138677000337 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 138677000338 active site 138677000339 HIGH motif; other site 138677000340 KMSKS motif; other site 138677000341 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 138677000342 tRNA binding surface [nucleotide binding]; other site 138677000343 anticodon binding site; other site 138677000344 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 138677000345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 138677000346 Walker A motif; other site 138677000347 ATP binding site [chemical binding]; other site 138677000348 Walker B motif; other site 138677000349 Family description; Region: UvrD_C_2; pfam13538 138677000350 IncA protein; Region: IncA; pfam04156 138677000351 Domain of unknown function (DUF1978); Region: DUF1978; pfam09321 138677000352 Hydrogenase formation hypA family; Region: HypD; cl12072 138677000353 Domain of unknown function (DUF1978); Region: DUF1978; pfam09321 138677000354 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 138677000355 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 138677000356 conserved cys residue [active] 138677000357 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 138677000358 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 138677000359 ring oligomerisation interface [polypeptide binding]; other site 138677000360 ATP/Mg binding site [chemical binding]; other site 138677000361 stacking interactions; other site 138677000362 hinge regions; other site 138677000363 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 138677000364 oligomerisation interface [polypeptide binding]; other site 138677000365 mobile loop; other site 138677000366 roof hairpin; other site 138677000367 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 138677000368 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 138677000369 active site 138677000370 Zn binding site [ion binding]; other site 138677000371 Uncharacterized conserved protein [Function unknown]; Region: COG0327 138677000372 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 138677000373 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00615 138677000374 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 138677000375 inhibitor-cofactor binding pocket; inhibition site 138677000376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 138677000377 catalytic residue [active] 138677000378 Putative transcriptional regulator [Transcription]; Region: COG1678 138677000379 Uncharacterized conserved protein [Function unknown]; Region: COG1259 138677000380 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 138677000381 tetramer (dimer of dimers) interface [polypeptide binding]; other site 138677000382 active site 138677000383 dimer interface [polypeptide binding]; other site 138677000384 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 138677000385 substrate binding site [chemical binding]; other site 138677000386 THF binding site; other site 138677000387 zinc-binding site [ion binding]; other site 138677000388 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 138677000389 Clp amino terminal domain; Region: Clp_N; pfam02861 138677000390 Clp amino terminal domain; Region: Clp_N; pfam02861 138677000391 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 138677000392 Walker A motif; other site 138677000393 ATP binding site [chemical binding]; other site 138677000394 Walker B motif; other site 138677000395 arginine finger; other site 138677000396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 138677000397 Walker A motif; other site 138677000398 ATP binding site [chemical binding]; other site 138677000399 Walker B motif; other site 138677000400 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 138677000401 Uncharacterized conserved protein [Function unknown]; Region: COG2912 138677000402 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 138677000403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 138677000404 TPR motif; other site 138677000405 binding surface 138677000406 TPR repeat; Region: TPR_11; pfam13414 138677000407 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 138677000408 Catalytic domain of Protein Kinases; Region: PKc; cd00180 138677000409 active site 138677000410 ATP binding site [chemical binding]; other site 138677000411 substrate binding site [chemical binding]; other site 138677000412 activation loop (A-loop); other site 138677000413 Uncharacterized conserved protein [Function unknown]; Region: COG1262 138677000414 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 138677000415 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 138677000416 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 138677000417 nucleotide binding pocket [chemical binding]; other site 138677000418 K-X-D-G motif; other site 138677000419 catalytic site [active] 138677000420 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 138677000421 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 138677000422 Helix-hairpin-helix motif; Region: HHH; pfam00633 138677000423 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 138677000424 Dimer interface [polypeptide binding]; other site 138677000425 BRCT sequence motif; other site 138677000426 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 138677000427 TrkA-N domain; Region: TrkA_N; pfam02254 138677000428 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 138677000429 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 138677000430 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 138677000431 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 138677000432 HIGH motif; other site 138677000433 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 138677000434 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 138677000435 active site 138677000436 KMSKS motif; other site 138677000437 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 138677000438 tRNA binding surface [nucleotide binding]; other site 138677000439 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 138677000440 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 138677000441 Family of unknown function (DUF648); Region: DUF648; pfam04890 138677000442 Family of unknown function (DUF648); Region: DUF648; pfam04890 138677000443 Family of unknown function (DUF648); Region: DUF648; pfam04890 138677000444 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 138677000445 active site 138677000446 ADP/pyrophosphate binding site [chemical binding]; other site 138677000447 dimerization interface [polypeptide binding]; other site 138677000448 allosteric effector site; other site 138677000449 fructose-1,6-bisphosphate binding site; other site 138677000450 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 138677000451 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 138677000452 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 138677000453 Family of unknown function (DUF648); Region: DUF648; pfam04890 138677000454 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 138677000455 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 138677000456 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 138677000457 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 138677000458 AMP/PPi binding site [chemical binding]; other site 138677000459 candidate oxyanion hole; other site 138677000460 catalytic triad [active] 138677000461 potential glutamine specificity residues [chemical binding]; other site 138677000462 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 138677000463 ATP Binding subdomain [chemical binding]; other site 138677000464 Dimerization subdomain; other site 138677000465 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 138677000466 active site 138677000467 membrane-attack complex / perforin; Region: MACPF; smart00457 138677000468 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 138677000469 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 138677000470 putative active site pocket [active] 138677000471 dimerization interface [polypeptide binding]; other site 138677000472 putative catalytic residue [active] 138677000473 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 138677000474 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 138677000475 ATP-grasp domain; Region: ATP-grasp_4; cl17255 138677000476 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 138677000477 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 138677000478 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 138677000479 carboxyltransferase (CT) interaction site; other site 138677000480 biotinylation site [posttranslational modification]; other site 138677000481 elongation factor P; Provisional; Region: PRK12426 138677000482 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 138677000483 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 138677000484 RNA binding site [nucleotide binding]; other site 138677000485 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 138677000486 RNA binding site [nucleotide binding]; other site 138677000487 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 138677000488 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 138677000489 substrate binding site [chemical binding]; other site 138677000490 hexamer interface [polypeptide binding]; other site 138677000491 metal binding site [ion binding]; metal-binding site 138677000492 IncA protein; Region: IncA; pfam04156 138677000493 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 138677000494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 138677000495 S-adenosylmethionine binding site [chemical binding]; other site 138677000496 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 138677000497 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 138677000498 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 138677000499 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 138677000500 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 138677000501 Walker A/P-loop; other site 138677000502 ATP binding site [chemical binding]; other site 138677000503 Q-loop/lid; other site 138677000504 ABC transporter signature motif; other site 138677000505 Walker B; other site 138677000506 D-loop; other site 138677000507 H-loop/switch region; other site 138677000508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 138677000509 dimer interface [polypeptide binding]; other site 138677000510 conserved gate region; other site 138677000511 putative PBP binding loops; other site 138677000512 ABC-ATPase subunit interface; other site 138677000513 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 138677000514 arginine repressor; Region: argR_whole; TIGR01529 138677000515 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 138677000516 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 138677000517 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 138677000518 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 138677000519 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 138677000520 peptide binding site [polypeptide binding]; other site 138677000521 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 138677000522 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 138677000523 peptide binding site [polypeptide binding]; other site 138677000524 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 138677000525 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 138677000526 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 138677000527 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 138677000528 peptide binding site [polypeptide binding]; other site 138677000529 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 138677000530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 138677000531 dimer interface [polypeptide binding]; other site 138677000532 conserved gate region; other site 138677000533 putative PBP binding loops; other site 138677000534 ABC-ATPase subunit interface; other site 138677000535 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 138677000536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 138677000537 putative PBP binding loops; other site 138677000538 dimer interface [polypeptide binding]; other site 138677000539 ABC-ATPase subunit interface; other site 138677000540 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 138677000541 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 138677000542 Walker A/P-loop; other site 138677000543 ATP binding site [chemical binding]; other site 138677000544 Q-loop/lid; other site 138677000545 ABC transporter signature motif; other site 138677000546 Walker B; other site 138677000547 D-loop; other site 138677000548 H-loop/switch region; other site 138677000549 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 138677000550 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 138677000551 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 138677000552 Walker A/P-loop; other site 138677000553 ATP binding site [chemical binding]; other site 138677000554 Q-loop/lid; other site 138677000555 ABC transporter signature motif; other site 138677000556 Walker B; other site 138677000557 D-loop; other site 138677000558 H-loop/switch region; other site 138677000559 Family of unknown function (DUF648); Region: DUF648; pfam04890 138677000560 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 138677000561 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 138677000562 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 138677000563 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 138677000564 transmembrane helices; other site 138677000565 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 138677000566 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 138677000567 active site 138677000568 ADP/pyrophosphate binding site [chemical binding]; other site 138677000569 dimerization interface [polypeptide binding]; other site 138677000570 allosteric effector site; other site 138677000571 fructose-1,6-bisphosphate binding site; other site 138677000572 Family of unknown function (DUF648); Region: DUF648; pfam04890 138677000573 IncA protein; Region: IncA; pfam04156 138677000574 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 138677000575 conserved hypothetical integral membrane protein; Region: TIGR00697 138677000576 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 138677000577 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 138677000578 putative replication initiation protein; Region: PHA00330 138677000579 IncA protein; Region: IncA; pfam04156 138677000580 putative disulfide oxidoreductase; Provisional; Region: PRK00611 138677000581 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 138677000582 Thioredoxin; Region: Thioredoxin_4; pfam13462 138677000583 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 138677000584 putative active site [active] 138677000585 redox center [active] 138677000586 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 138677000587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 138677000588 Walker A/P-loop; other site 138677000589 ATP binding site [chemical binding]; other site 138677000590 Q-loop/lid; other site 138677000591 ABC transporter signature motif; other site 138677000592 Walker B; other site 138677000593 D-loop; other site 138677000594 H-loop/switch region; other site 138677000595 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 138677000596 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 138677000597 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 138677000598 Ligand binding site; other site 138677000599 oligomer interface; other site 138677000600 CTP synthetase; Validated; Region: pyrG; PRK05380 138677000601 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 138677000602 Catalytic site [active] 138677000603 active site 138677000604 UTP binding site [chemical binding]; other site 138677000605 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 138677000606 active site 138677000607 putative oxyanion hole; other site 138677000608 catalytic triad [active] 138677000609 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 138677000610 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 138677000611 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 138677000612 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 138677000613 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 138677000614 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 138677000615 putative active site [active] 138677000616 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 138677000617 adenylate kinase; Region: adk; TIGR01351 138677000618 AMP-binding site [chemical binding]; other site 138677000619 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 138677000620 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 138677000621 NlpC/P60 family; Region: NLPC_P60; cl17555 138677000622 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 138677000623 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 138677000624 23S rRNA interface [nucleotide binding]; other site 138677000625 L3 interface [polypeptide binding]; other site 138677000626 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 138677000627 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 138677000628 Walker A/P-loop; other site 138677000629 ATP binding site [chemical binding]; other site 138677000630 Q-loop/lid; other site 138677000631 ABC transporter signature motif; other site 138677000632 Walker B; other site 138677000633 D-loop; other site 138677000634 H-loop/switch region; other site 138677000635 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 138677000636 FtsX-like permease family; Region: FtsX; pfam02687 138677000637 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 138677000638 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 138677000639 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 138677000640 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 138677000641 SEC-C motif; Region: SEC-C; pfam02810 138677000642 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 138677000643 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 138677000644 Ligand Binding Site [chemical binding]; other site 138677000645 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 138677000646 Uncharacterized conserved protein [Function unknown]; Region: COG1284 138677000647 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 138677000648 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 138677000649 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 138677000650 aromatic acid decarboxylase; Validated; Region: PRK05920 138677000651 Flavoprotein; Region: Flavoprotein; pfam02441 138677000652 prenyltransferase; Reviewed; Region: ubiA; PRK12876 138677000653 UbiA prenyltransferase family; Region: UbiA; pfam01040 138677000654 IncA protein; Region: IncA; pfam04156 138677000655 IncA protein; Region: IncA; pfam04156 138677000656 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 138677000657 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 138677000658 active site 138677000659 dimer interface [polypeptide binding]; other site 138677000660 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 138677000661 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 138677000662 Serine hydrolase (FSH1); Region: FSH1; pfam03959 138677000663 DNA polymerase III subunit delta'; Validated; Region: PRK05917 138677000664 DNA polymerase III subunit delta'; Validated; Region: PRK08485 138677000665 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 138677000666 thymidylate kinase; Validated; Region: tmk; PRK00698 138677000667 TMP-binding site; other site 138677000668 ATP-binding site [chemical binding]; other site 138677000669 DNA gyrase, A subunit; Region: gyrA; TIGR01063 138677000670 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 138677000671 CAP-like domain; other site 138677000672 active site 138677000673 primary dimer interface [polypeptide binding]; other site 138677000674 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 138677000675 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 138677000676 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 138677000677 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 138677000678 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 138677000679 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 138677000680 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 138677000681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 138677000682 ATP binding site [chemical binding]; other site 138677000683 Mg2+ binding site [ion binding]; other site 138677000684 G-X-G motif; other site 138677000685 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 138677000686 anchoring element; other site 138677000687 dimer interface [polypeptide binding]; other site 138677000688 ATP binding site [chemical binding]; other site 138677000689 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 138677000690 active site 138677000691 putative metal-binding site [ion binding]; other site 138677000692 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 138677000693 Protein of unknown function (DUF721); Region: DUF721; cl02324 138677000694 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 138677000695 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 138677000696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 138677000697 dimer interface [polypeptide binding]; other site 138677000698 conserved gate region; other site 138677000699 putative PBP binding loops; other site 138677000700 ABC-ATPase subunit interface; other site 138677000701 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 138677000702 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 138677000703 Walker A/P-loop; other site 138677000704 ATP binding site [chemical binding]; other site 138677000705 Q-loop/lid; other site 138677000706 ABC transporter signature motif; other site 138677000707 Walker B; other site 138677000708 D-loop; other site 138677000709 H-loop/switch region; other site 138677000710 NIL domain; Region: NIL; pfam09383 138677000711 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 138677000712 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 138677000713 putative active site; other site 138677000714 catalytic residue [active] 138677000715 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 138677000716 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 138677000717 MgtE intracellular N domain; Region: MgtE_N; pfam03448 138677000718 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 138677000719 Divalent cation transporter; Region: MgtE; pfam01769 138677000720 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 138677000721 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 138677000722 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 138677000723 Na2 binding site [ion binding]; other site 138677000724 putative substrate binding site 1 [chemical binding]; other site 138677000725 Na binding site 1 [ion binding]; other site 138677000726 putative substrate binding site 2 [chemical binding]; other site 138677000727 TLC ATP/ADP transporter; Region: TLC; cl03940 138677000728 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 138677000729 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 138677000730 ligand binding site [chemical binding]; other site 138677000731 flexible hinge region; other site 138677000732 acyl carrier protein; Provisional; Region: acpP; PRK00982 138677000733 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 138677000734 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 138677000735 NAD(P) binding site [chemical binding]; other site 138677000736 homotetramer interface [polypeptide binding]; other site 138677000737 homodimer interface [polypeptide binding]; other site 138677000738 active site 138677000739 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 138677000740 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 138677000741 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 138677000742 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 138677000743 dimer interface [polypeptide binding]; other site 138677000744 active site 138677000745 CoA binding pocket [chemical binding]; other site 138677000746 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 138677000747 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 138677000748 putative active site [active] 138677000749 putative metal-binding site [ion binding]; other site 138677000750 tetramer interface [polypeptide binding]; other site 138677000751 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 138677000752 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 138677000753 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 138677000754 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 138677000755 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 138677000756 Surface antigen; Region: Bac_surface_Ag; pfam01103 138677000757 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 138677000758 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 138677000759 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 138677000760 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 138677000761 trimer interface [polypeptide binding]; other site 138677000762 active site 138677000763 UDP-GlcNAc binding site [chemical binding]; other site 138677000764 lipid binding site [chemical binding]; lipid-binding site 138677000765 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 138677000766 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 138677000767 tetramer interface [polypeptide binding]; other site 138677000768 TPP-binding site [chemical binding]; other site 138677000769 heterodimer interface [polypeptide binding]; other site 138677000770 phosphorylation loop region [posttranslational modification] 138677000771 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 138677000772 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 138677000773 alpha subunit interface [polypeptide binding]; other site 138677000774 TPP binding site [chemical binding]; other site 138677000775 heterodimer interface [polypeptide binding]; other site 138677000776 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 138677000777 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 138677000778 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 138677000779 E3 interaction surface; other site 138677000780 lipoyl attachment site [posttranslational modification]; other site 138677000781 e3 binding domain; Region: E3_binding; pfam02817 138677000782 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 138677000783 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 138677000784 homodimer interface [polypeptide binding]; other site 138677000785 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 138677000786 active site pocket [active] 138677000787 chromosomal replication initiation protein; Provisional; Region: PRK12422 138677000788 DnaA N-terminal domain; Region: DnaA_N; pfam11638 138677000789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 138677000790 Walker A motif; other site 138677000791 ATP binding site [chemical binding]; other site 138677000792 Walker B motif; other site 138677000793 arginine finger; other site 138677000794 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 138677000795 DnaA box-binding interface [nucleotide binding]; other site 138677000796 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 138677000797 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 138677000798 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 138677000799 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 138677000800 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 138677000801 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 138677000802 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 138677000803 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 138677000804 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 138677000805 RNA binding site [nucleotide binding]; other site 138677000806 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 138677000807 RNA binding site [nucleotide binding]; other site 138677000808 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 138677000809 RNA binding site [nucleotide binding]; other site 138677000810 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 138677000811 RNA binding site [nucleotide binding]; other site 138677000812 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 138677000813 RNA binding site [nucleotide binding]; other site 138677000814 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 138677000815 RNA binding site [nucleotide binding]; other site 138677000816 transcription termination factor NusA; Region: NusA; TIGR01953 138677000817 NusA N-terminal domain; Region: NusA_N; pfam08529 138677000818 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 138677000819 RNA binding site [nucleotide binding]; other site 138677000820 homodimer interface [polypeptide binding]; other site 138677000821 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 138677000822 G-X-X-G motif; other site 138677000823 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 138677000824 G-X-X-G motif; other site 138677000825 translation initiation factor IF-2; Validated; Region: infB; PRK05306 138677000826 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 138677000827 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 138677000828 G1 box; other site 138677000829 putative GEF interaction site [polypeptide binding]; other site 138677000830 GTP/Mg2+ binding site [chemical binding]; other site 138677000831 Switch I region; other site 138677000832 G2 box; other site 138677000833 G3 box; other site 138677000834 Switch II region; other site 138677000835 G4 box; other site 138677000836 G5 box; other site 138677000837 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 138677000838 Translation-initiation factor 2; Region: IF-2; pfam11987 138677000839 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 138677000840 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 138677000841 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 138677000842 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 138677000843 RNA binding site [nucleotide binding]; other site 138677000844 active site 138677000845 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 138677000846 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 138677000847 active site 138677000848 Riboflavin kinase; Region: Flavokinase; pfam01687 138677000849 GTP-binding protein YchF; Reviewed; Region: PRK09601 138677000850 YchF GTPase; Region: YchF; cd01900 138677000851 G1 box; other site 138677000852 GTP/Mg2+ binding site [chemical binding]; other site 138677000853 Switch I region; other site 138677000854 G2 box; other site 138677000855 Switch II region; other site 138677000856 G3 box; other site 138677000857 G4 box; other site 138677000858 G5 box; other site 138677000859 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 138677000860 type III secretion system protein; Validated; Region: PRK06298 138677000861 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 138677000862 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 138677000863 FHIPEP family; Region: FHIPEP; pfam00771 138677000864 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 138677000865 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 138677000866 4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446 138677000867 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 138677000868 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 138677000869 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 138677000870 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 138677000871 PLD-like domain; Region: PLDc_2; pfam13091 138677000872 putative active site [active] 138677000873 catalytic site [active] 138677000874 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 138677000875 PLD-like domain; Region: PLDc_2; pfam13091 138677000876 putative active site [active] 138677000877 catalytic site [active] 138677000878 molecular chaperone DnaK; Provisional; Region: PRK13410 138677000879 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 138677000880 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 138677000881 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 138677000882 homodimer interface [polypeptide binding]; other site 138677000883 NADP binding site [chemical binding]; other site 138677000884 substrate binding site [chemical binding]; other site 138677000885 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 138677000886 ApbE family; Region: ApbE; pfam02424 138677000887 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 138677000888 SmpB-tmRNA interface; other site 138677000889 DNA polymerase III subunit beta; Validated; Region: PRK05643 138677000890 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 138677000891 putative DNA binding surface [nucleotide binding]; other site 138677000892 dimer interface [polypeptide binding]; other site 138677000893 beta-clamp/clamp loader binding surface; other site 138677000894 beta-clamp/translesion DNA polymerase binding surface; other site 138677000895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 138677000896 ATP binding site [chemical binding]; other site 138677000897 Walker A/P-loop; other site 138677000898 Q-loop/lid; other site 138677000899 recombination protein F; Reviewed; Region: recF; PRK00064 138677000900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 138677000901 ABC transporter signature motif; other site 138677000902 Walker B; other site 138677000903 D-loop; other site 138677000904 H-loop/switch region; other site 138677000905 Putative serine esterase (DUF676); Region: DUF676; pfam05057 138677000906 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 138677000907 RIP metalloprotease RseP; Region: TIGR00054 138677000908 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 138677000909 active site 138677000910 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 138677000911 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 138677000912 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 138677000913 putative substrate binding region [chemical binding]; other site 138677000914 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 138677000915 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 138677000916 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 138677000917 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 138677000918 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 138677000919 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 138677000920 ABC-ATPase subunit interface; other site 138677000921 dimer interface [polypeptide binding]; other site 138677000922 putative PBP binding regions; other site 138677000923 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 138677000924 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 138677000925 ABC-ATPase subunit interface; other site 138677000926 dimer interface [polypeptide binding]; other site 138677000927 putative PBP binding regions; other site 138677000928 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 138677000929 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 138677000930 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 138677000931 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 138677000932 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 138677000933 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 138677000934 metal binding site [ion binding]; metal-binding site 138677000935 intersubunit interface [polypeptide binding]; other site 138677000936 ADP/ATP carrier protein family; Region: AAA; TIGR00769 138677000937 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 138677000938 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 138677000939 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 138677000940 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 138677000941 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 138677000942 GTP-binding protein LepA; Provisional; Region: PRK05433 138677000943 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 138677000944 G1 box; other site 138677000945 putative GEF interaction site [polypeptide binding]; other site 138677000946 GTP/Mg2+ binding site [chemical binding]; other site 138677000947 Switch I region; other site 138677000948 G2 box; other site 138677000949 G3 box; other site 138677000950 Switch II region; other site 138677000951 G4 box; other site 138677000952 G5 box; other site 138677000953 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 138677000954 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 138677000955 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 138677000956 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 138677000957 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 138677000958 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 138677000959 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 138677000960 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 138677000961 active site 138677000962 HIGH motif; other site 138677000963 dimer interface [polypeptide binding]; other site 138677000964 KMSKS motif; other site 138677000965 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 138677000966 RNA binding surface [nucleotide binding]; other site 138677000967 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 138677000968 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 138677000969 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 138677000970 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 138677000971 DNA binding residues [nucleotide binding] 138677000972 type III secretion system protein; Validated; Region: PRK05910 138677000973 FHIPEP family; Region: FHIPEP; pfam00771 138677000974 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 138677000975 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 138677000976 catalytic loop [active] 138677000977 iron binding site [ion binding]; other site 138677000978 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 138677000979 ADP-ribose binding site [chemical binding]; other site 138677000980 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 138677000981 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 138677000982 ADP-ribose binding site [chemical binding]; other site 138677000983 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 138677000984 ADP-ribose binding site [chemical binding]; other site 138677000985 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 138677000986 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 138677000987 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 138677000988 uncharacterized protein, YfiH family; Region: TIGR00726 138677000989 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 138677000990 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 138677000991 E3 interaction surface; other site 138677000992 lipoyl attachment site [posttranslational modification]; other site 138677000993 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 138677000994 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 138677000995 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 138677000996 TPP-binding site [chemical binding]; other site 138677000997 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 138677000998 dimer interface [polypeptide binding]; other site 138677000999 PYR/PP interface [polypeptide binding]; other site 138677001000 TPP binding site [chemical binding]; other site 138677001001 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 138677001002 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 138677001003 FeS/SAM binding site; other site 138677001004 Protein of unknown function (DUF687); Region: DUF687; pfam05095 138677001005 Predicted methyltransferases [General function prediction only]; Region: COG0313 138677001006 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 138677001007 putative SAM binding site [chemical binding]; other site 138677001008 homodimer interface [polypeptide binding]; other site 138677001009 hypothetical protein; Provisional; Region: PRK05907 138677001010 multifunctional aminopeptidase A; Provisional; Region: PRK00913 138677001011 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 138677001012 interface (dimer of trimers) [polypeptide binding]; other site 138677001013 Substrate-binding/catalytic site; other site 138677001014 Zn-binding sites [ion binding]; other site 138677001015 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 138677001016 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 138677001017 ssDNA binding site [nucleotide binding]; other site 138677001018 dimer interface [polypeptide binding]; other site 138677001019 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 138677001020 tetramer (dimer of dimers) interface [polypeptide binding]; other site 138677001021 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 138677001022 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 138677001023 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 138677001024 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 138677001025 active site 138677001026 catalytic site [active] 138677001027 Stage II sporulation protein; Region: SpoIID; pfam08486 138677001028 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 138677001029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 138677001030 Walker A motif; other site 138677001031 ATP binding site [chemical binding]; other site 138677001032 Walker B motif; other site 138677001033 arginine finger; other site 138677001034 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 138677001035 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 138677001036 trimer interface [polypeptide binding]; other site 138677001037 active site 138677001038 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 138677001039 Domain of unknown function DUF21; Region: DUF21; pfam01595 138677001040 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 138677001041 Transporter associated domain; Region: CorC_HlyC; smart01091 138677001042 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 138677001043 Domain of unknown function DUF21; Region: DUF21; pfam01595 138677001044 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 138677001045 Transporter associated domain; Region: CorC_HlyC; smart01091 138677001046 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 138677001047 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 138677001048 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 138677001049 catalytic residue [active] 138677001050 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 138677001051 active site 138677001052 CAAX protease self-immunity; Region: Abi; pfam02517 138677001053 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 138677001054 homodimer interface [polypeptide binding]; other site 138677001055 metal binding site [ion binding]; metal-binding site 138677001056 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 138677001057 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 138677001058 minor groove reading motif; other site 138677001059 helix-hairpin-helix signature motif; other site 138677001060 substrate binding pocket [chemical binding]; other site 138677001061 active site 138677001062 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 138677001063 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 138677001064 DNA binding and oxoG recognition site [nucleotide binding] 138677001065 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 138677001066 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 138677001067 RNA binding surface [nucleotide binding]; other site 138677001068 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 138677001069 active site 138677001070 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 138677001071 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 138677001072 NAD binding site [chemical binding]; other site 138677001073 homotetramer interface [polypeptide binding]; other site 138677001074 homodimer interface [polypeptide binding]; other site 138677001075 substrate binding site [chemical binding]; other site 138677001076 active site 138677001077 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 138677001078 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 138677001079 active site 138677001080 motif I; other site 138677001081 motif II; other site 138677001082 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 138677001083 Uncharacterized conserved protein [Function unknown]; Region: COG5465 138677001084 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 138677001085 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 138677001086 active site 138677001087 catalytic site [active] 138677001088 substrate binding site [chemical binding]; other site 138677001089 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 138677001090 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 138677001091 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 138677001092 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 138677001093 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 138677001094 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 138677001095 Walker A/P-loop; other site 138677001096 ATP binding site [chemical binding]; other site 138677001097 Q-loop/lid; other site 138677001098 ABC transporter signature motif; other site 138677001099 Walker B; other site 138677001100 D-loop; other site 138677001101 H-loop/switch region; other site 138677001102 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 138677001103 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 138677001104 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 138677001105 IHF - DNA interface [nucleotide binding]; other site 138677001106 IHF dimer interface [polypeptide binding]; other site 138677001107 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 138677001108 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 138677001109 active site 138677001110 metal binding site [ion binding]; metal-binding site 138677001111 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 138677001112 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 138677001113 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 138677001114 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 138677001115 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 138677001116 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 138677001117 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 138677001118 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 138677001119 MraW methylase family; Region: Methyltransf_5; cl17771 138677001120 TPR repeat; Region: TPR_11; pfam13414 138677001121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 138677001122 TPR motif; other site 138677001123 binding surface 138677001124 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 138677001125 DnaA N-terminal domain; Region: DnaA_N; pfam11638 138677001126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 138677001127 Walker A motif; other site 138677001128 ATP binding site [chemical binding]; other site 138677001129 Walker B motif; other site 138677001130 arginine finger; other site 138677001131 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 138677001132 DnaA box-binding interface [nucleotide binding]; other site 138677001133 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 138677001134 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 138677001135 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 138677001136 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 138677001137 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 138677001138 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 138677001139 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 138677001140 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 138677001141 lipoyl attachment site [posttranslational modification]; other site 138677001142 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 138677001143 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 138677001144 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 138677001145 putative active site [active] 138677001146 catalytic site [active] 138677001147 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 138677001148 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 138677001149 Clp amino terminal domain; Region: Clp_N; pfam02861 138677001150 Clp amino terminal domain; Region: Clp_N; pfam02861 138677001151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 138677001152 Walker A motif; other site 138677001153 ATP binding site [chemical binding]; other site 138677001154 Walker B motif; other site 138677001155 arginine finger; other site 138677001156 UvrB/uvrC motif; Region: UVR; pfam02151 138677001157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 138677001158 Walker A motif; other site 138677001159 ATP binding site [chemical binding]; other site 138677001160 Walker B motif; other site 138677001161 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 138677001162 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 138677001163 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 138677001164 Ligand Binding Site [chemical binding]; other site 138677001165 Cell division protein ZapA; Region: ZapA; cl01146 138677001166 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 138677001167 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 138677001168 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 138677001169 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 138677001170 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677001171 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677001172 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677001173 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677001174 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677001175 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677001176 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 138677001177 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677001178 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677001179 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 138677001180 substrate binding site [chemical binding]; other site 138677001181 zinc-binding site [ion binding]; other site 138677001182 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 138677001183 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 138677001184 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677001185 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677001186 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 138677001187 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677001188 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677001189 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677001190 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677001191 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677001192 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677001193 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677001194 Protein of unknown function (DUF575); Region: DUF575; pfam04746 138677001195 Protein of unknown function (DUF562); Region: DUF562; pfam04763 138677001196 Protein of unknown function (DUF575); Region: DUF575; pfam04746 138677001197 Protein of unknown function (DUF562); Region: DUF562; pfam04763 138677001198 Protein of unknown function (DUF575); Region: DUF575; pfam04746 138677001199 Protein of unknown function (DUF562); Region: DUF562; pfam04763 138677001200 Protein of unknown function (DUF562); Region: DUF562; pfam04763 138677001201 Protein of unknown function (DUF575); Region: DUF575; pfam04746 138677001202 Protein of unknown function (DUF575); Region: DUF575; pfam04746 138677001203 Protein of unknown function (DUF562); Region: DUF562; pfam04763 138677001204 Protein of unknown function (DUF562); Region: DUF562; pfam04763 138677001205 Protein of unknown function (DUF575); Region: DUF575; pfam04746 138677001206 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 138677001207 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677001208 Autotransporter beta-domain; Region: Autotransporter; smart00869 138677001209 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677001210 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677001211 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677001212 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677001213 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677001214 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 138677001215 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 138677001216 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677001217 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677001218 glycogen branching enzyme; Provisional; Region: PRK05402 138677001219 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 138677001220 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 138677001221 active site 138677001222 catalytic site [active] 138677001223 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 138677001224 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 138677001225 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 138677001226 GTPases [General function prediction only]; Region: HflX; COG2262 138677001227 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 138677001228 HflX GTPase family; Region: HflX; cd01878 138677001229 G1 box; other site 138677001230 GTP/Mg2+ binding site [chemical binding]; other site 138677001231 Switch I region; other site 138677001232 G2 box; other site 138677001233 G3 box; other site 138677001234 Switch II region; other site 138677001235 G4 box; other site 138677001236 G5 box; other site 138677001237 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 138677001238 putative hydrolase; Provisional; Region: PRK02113 138677001239 Protein of unknown function (DUF3487); Region: DUF3487; cl13432 138677001240 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 138677001241 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 138677001242 substrate binding pocket [chemical binding]; other site 138677001243 membrane-bound complex binding site; other site 138677001244 hinge residues; other site 138677001245 Peptidase C65 Otubain; Region: Peptidase_C65; pfam10275 138677001246 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 138677001247 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 138677001248 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 138677001249 Na binding site [ion binding]; other site 138677001250 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 138677001251 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 138677001252 nucleotide binding site/active site [active] 138677001253 HIT family signature motif; other site 138677001254 catalytic residue [active] 138677001255 Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286 138677001256 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 138677001257 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 138677001258 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 138677001259 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 138677001260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 138677001261 homodimer interface [polypeptide binding]; other site 138677001262 catalytic residue [active] 138677001263 ABC transporter substrate binding protein; Region: ABC_sub_bind; pfam04392 138677001264 hypothetical protein; Validated; Region: PRK00647 138677001265 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 138677001266 Acetokinase family; Region: Acetate_kinase; cl17229 138677001267 prolyl-tRNA synthetase; Provisional; Region: PRK09194 138677001268 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 138677001269 motif 1; other site 138677001270 dimer interface [polypeptide binding]; other site 138677001271 active site 138677001272 motif 2; other site 138677001273 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 138677001274 putative deacylase active site [active] 138677001275 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 138677001276 active site 138677001277 motif 3; other site 138677001278 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 138677001279 anticodon binding site; other site 138677001280 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 138677001281 GrpE; Region: GrpE; pfam01025 138677001282 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 138677001283 dimer interface [polypeptide binding]; other site 138677001284 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 138677001285 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 138677001286 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 138677001287 nucleotide binding site [chemical binding]; other site 138677001288 NEF interaction site [polypeptide binding]; other site 138677001289 SBD interface [polypeptide binding]; other site 138677001290 Exoribonuclease R [Transcription]; Region: VacB; COG0557 138677001291 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 138677001292 RNA binding site [nucleotide binding]; other site 138677001293 RNB domain; Region: RNB; pfam00773 138677001294 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 138677001295 active site 138677001296 DNA binding site [nucleotide binding] 138677001297 Uncharacterized conserved protein [Function unknown]; Region: COG2928 138677001298 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 138677001299 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 138677001300 FOG: CBS domain [General function prediction only]; Region: COG0517 138677001301 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 138677001302 Transporter associated domain; Region: CorC_HlyC; smart01091 138677001303 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 138677001304 anti sigma factor interaction site; other site 138677001305 regulatory phosphorylation site [posttranslational modification]; other site 138677001306 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 138677001307 hypothetical protein; Provisional; Region: PRK05926 138677001308 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 138677001309 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 138677001310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 138677001311 S-adenosylmethionine binding site [chemical binding]; other site 138677001312 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907 138677001313 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 138677001314 diaminopimelate epimerase; Region: DapF; TIGR00652 138677001315 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 138677001316 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 138677001317 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 138677001318 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 138677001319 oligomer interface [polypeptide binding]; other site 138677001320 active site residues [active] 138677001321 serine hydroxymethyltransferase; Provisional; Region: PRK13580 138677001322 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 138677001323 dimer interface [polypeptide binding]; other site 138677001324 active site 138677001325 glycine-pyridoxal phosphate binding site [chemical binding]; other site 138677001326 folate binding site [chemical binding]; other site 138677001327 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 138677001328 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 138677001329 active site 138677001330 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 138677001331 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 138677001332 Putative zinc ribbon domain; Region: DUF164; pfam02591 138677001333 KpsF/GutQ family protein; Region: kpsF; TIGR00393 138677001334 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 138677001335 putative active site [active] 138677001336 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 138677001337 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 138677001338 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 138677001339 E3 interaction surface; other site 138677001340 lipoyl attachment site [posttranslational modification]; other site 138677001341 e3 binding domain; Region: E3_binding; pfam02817 138677001342 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 138677001343 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 138677001344 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 138677001345 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 138677001346 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 138677001347 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 138677001348 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 138677001349 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 138677001350 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 138677001351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 138677001352 S-adenosylmethionine binding site [chemical binding]; other site 138677001353 Riboflavin synthase alpha chain [Coenzyme metabolism]; Region: RibC; COG0307 138677001354 Lumazine binding domain; Region: Lum_binding; pfam00677 138677001355 Lumazine binding domain; Region: Lum_binding; pfam00677 138677001356 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 138677001357 ATP cone domain; Region: ATP-cone; pfam03477 138677001358 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 138677001359 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 138677001360 lipoprotein signal peptidase; Provisional; Region: PRK14787 138677001361 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 138677001362 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 138677001363 YtxH-like protein; Region: YtxH; pfam12732 138677001364 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677001365 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677001366 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677001367 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677001368 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 138677001369 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 138677001370 putative metal binding residues [ion binding]; other site 138677001371 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 138677001372 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 138677001373 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 138677001374 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 138677001375 ABC-ATPase subunit interface; other site 138677001376 dimer interface [polypeptide binding]; other site 138677001377 putative PBP binding regions; other site 138677001378 GTPase CgtA; Reviewed; Region: obgE; PRK12299 138677001379 GTP1/OBG; Region: GTP1_OBG; pfam01018 138677001380 Obg GTPase; Region: Obg; cd01898 138677001381 G1 box; other site 138677001382 GTP/Mg2+ binding site [chemical binding]; other site 138677001383 Switch I region; other site 138677001384 G2 box; other site 138677001385 G3 box; other site 138677001386 Switch II region; other site 138677001387 G4 box; other site 138677001388 G5 box; other site 138677001389 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 138677001390 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 138677001391 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 138677001392 homotrimer interaction site [polypeptide binding]; other site 138677001393 zinc binding site [ion binding]; other site 138677001394 CDP-binding sites; other site 138677001395 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 138677001396 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 138677001397 FAD binding pocket [chemical binding]; other site 138677001398 conserved FAD binding motif [chemical binding]; other site 138677001399 phosphate binding motif [ion binding]; other site 138677001400 beta-alpha-beta structure motif; other site 138677001401 NAD binding pocket [chemical binding]; other site 138677001402 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 138677001403 elongation factor G; Reviewed; Region: PRK12739 138677001404 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 138677001405 G1 box; other site 138677001406 putative GEF interaction site [polypeptide binding]; other site 138677001407 GTP/Mg2+ binding site [chemical binding]; other site 138677001408 Switch I region; other site 138677001409 G2 box; other site 138677001410 G3 box; other site 138677001411 Switch II region; other site 138677001412 G4 box; other site 138677001413 G5 box; other site 138677001414 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 138677001415 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 138677001416 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 138677001417 30S ribosomal protein S7; Validated; Region: PRK05302 138677001418 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 138677001419 S17 interaction site [polypeptide binding]; other site 138677001420 S8 interaction site; other site 138677001421 16S rRNA interaction site [nucleotide binding]; other site 138677001422 streptomycin interaction site [chemical binding]; other site 138677001423 23S rRNA interaction site [nucleotide binding]; other site 138677001424 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 138677001425 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 138677001426 Opioid growth factor receptor (OGFr) conserved region; Region: OGFr_N; pfam04664 138677001427 C-terminal peptidase (prc); Region: prc; TIGR00225 138677001428 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 138677001429 protein binding site [polypeptide binding]; other site 138677001430 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 138677001431 Catalytic dyad [active] 138677001432 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 138677001433 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 138677001434 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 138677001435 Domain of unknown function DUF11; Region: DUF11; pfam01345 138677001436 Domain of unknown function DUF11; Region: DUF11; pfam01345 138677001437 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 138677001438 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 138677001439 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 138677001440 HIGH motif; other site 138677001441 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 138677001442 active site 138677001443 KMSKS motif; other site 138677001444 Helix-turn-helix domain; Region: HTH_17; pfam12728 138677001445 Helix-turn-helix domain; Region: HTH_17; pfam12728 138677001446 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 138677001447 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 138677001448 DHH family; Region: DHH; pfam01368 138677001449 DHHA1 domain; Region: DHHA1; pfam02272 138677001450 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 138677001451 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 138677001452 Protein export membrane protein; Region: SecD_SecF; pfam02355 138677001453 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 138677001454 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 138677001455 catalytic residue [active] 138677001456 putative FPP diphosphate binding site; other site 138677001457 putative FPP binding hydrophobic cleft; other site 138677001458 dimer interface [polypeptide binding]; other site 138677001459 putative IPP diphosphate binding site; other site 138677001460 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 138677001461 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 138677001462 cytidylate kinase; Provisional; Region: cmk; PRK00023 138677001463 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 138677001464 CMP-binding site; other site 138677001465 The sites determining sugar specificity; other site 138677001466 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 138677001467 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 138677001468 putative acyl-acceptor binding pocket; other site 138677001469 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 138677001470 arginine-tRNA ligase; Region: PLN02286 138677001471 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 138677001472 active site 138677001473 HIGH motif; other site 138677001474 KMSK motif region; other site 138677001475 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 138677001476 tRNA binding surface [nucleotide binding]; other site 138677001477 anticodon binding site; other site 138677001478 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 138677001479 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 138677001480 hinge; other site 138677001481 active site 138677001482 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 138677001483 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 138677001484 SprT-like family; Region: SprT-like; pfam10263 138677001485 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 138677001486 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 138677001487 Coenzyme A binding pocket [chemical binding]; other site 138677001488 This domain is found in peptide chain release factors; Region: PCRF; smart00937 138677001489 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 138677001490 RF-1 domain; Region: RF-1; pfam00472 138677001491 SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531 138677001492 SWIB/MDM2 domain; Region: SWIB; pfam02201 138677001493 phosphodiesterase YaeI; Provisional; Region: PRK11340 138677001494 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 138677001495 putative active site [active] 138677001496 putative metal binding site [ion binding]; other site 138677001497 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 138677001498 substrate binding site; other site 138677001499 dimer interface; other site 138677001500 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 138677001501 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 138677001502 dimerization interface 3.5A [polypeptide binding]; other site 138677001503 active site 138677001504 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 138677001505 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 138677001506 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 138677001507 putative active site [active] 138677001508 heme pocket [chemical binding]; other site 138677001509 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 138677001510 dimer interface [polypeptide binding]; other site 138677001511 phosphorylation site [posttranslational modification] 138677001512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 138677001513 ATP binding site [chemical binding]; other site 138677001514 Mg2+ binding site [ion binding]; other site 138677001515 G-X-G motif; other site 138677001516 IncA protein; Region: IncA; pfam04156 138677001517 Response regulator receiver domain; Region: Response_reg; pfam00072 138677001518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 138677001519 active site 138677001520 phosphorylation site [posttranslational modification] 138677001521 intermolecular recognition site; other site 138677001522 dimerization interface [polypeptide binding]; other site 138677001523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 138677001524 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 138677001525 Walker A motif; other site 138677001526 ATP binding site [chemical binding]; other site 138677001527 Walker B motif; other site 138677001528 arginine finger; other site 138677001529 Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis]; Region: COG1544 138677001530 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 138677001531 Recombination protein O N terminal; Region: RecO_N; pfam11967 138677001532 DNA repair protein RecO; Region: reco; TIGR00613 138677001533 Recombination protein O C terminal; Region: RecO_C; pfam02565 138677001534 Uncharacterized conserved protein [Function unknown]; Region: COG1723 138677001535 hypothetical protein; Provisional; Region: PRK14381 138677001536 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 138677001537 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 138677001538 phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472 138677001539 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 138677001540 putative tRNA-binding site [nucleotide binding]; other site 138677001541 B3/4 domain; Region: B3_4; pfam03483 138677001542 tRNA synthetase B5 domain; Region: B5; smart00874 138677001543 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 138677001544 dimer interface [polypeptide binding]; other site 138677001545 motif 1; other site 138677001546 motif 3; other site 138677001547 motif 2; other site 138677001548 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 138677001549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 138677001550 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 138677001551 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 138677001552 DNA binding site [nucleotide binding] 138677001553 active site 138677001554 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 138677001555 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 138677001556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 138677001557 dimer interface [polypeptide binding]; other site 138677001558 conserved gate region; other site 138677001559 putative PBP binding loops; other site 138677001560 ABC-ATPase subunit interface; other site 138677001561 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 138677001562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 138677001563 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 138677001564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 138677001565 dimer interface [polypeptide binding]; other site 138677001566 conserved gate region; other site 138677001567 ABC-ATPase subunit interface; other site 138677001568 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 138677001569 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 138677001570 peptide binding site [polypeptide binding]; other site 138677001571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 138677001572 TPR motif; other site 138677001573 binding surface 138677001574 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 138677001575 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 138677001576 C-terminal domain interface [polypeptide binding]; other site 138677001577 active site 138677001578 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 138677001579 active site 138677001580 N-terminal domain interface [polypeptide binding]; other site 138677001581 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 138677001582 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 138677001583 substrate binding pocket [chemical binding]; other site 138677001584 membrane-bound complex binding site; other site 138677001585 hinge residues; other site 138677001586 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 138677001587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 138677001588 S-adenosylmethionine binding site [chemical binding]; other site 138677001589 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 138677001590 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 138677001591 putative active site [active] 138677001592 putative metal binding site [ion binding]; other site 138677001593 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 138677001594 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 138677001595 ligand binding site; other site 138677001596 oligomer interface; other site 138677001597 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 138677001598 dimer interface [polypeptide binding]; other site 138677001599 N-terminal domain interface [polypeptide binding]; other site 138677001600 sulfate 1 binding site; other site 138677001601 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 138677001602 active site 138677001603 transcription termination factor Rho; Provisional; Region: rho; PRK09376 138677001604 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 138677001605 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 138677001606 RNA binding site [nucleotide binding]; other site 138677001607 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 138677001608 multimer interface [polypeptide binding]; other site 138677001609 Walker A motif; other site 138677001610 ATP binding site [chemical binding]; other site 138677001611 Walker B motif; other site 138677001612 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 138677001613 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 138677001614 CoA-binding site [chemical binding]; other site 138677001615 ATP-binding [chemical binding]; other site 138677001616 DNA polymerase I; Provisional; Region: PRK05755 138677001617 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 138677001618 active site 138677001619 metal binding site 1 [ion binding]; metal-binding site 138677001620 putative 5' ssDNA interaction site; other site 138677001621 metal binding site 3; metal-binding site 138677001622 metal binding site 2 [ion binding]; metal-binding site 138677001623 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 138677001624 putative DNA binding site [nucleotide binding]; other site 138677001625 putative metal binding site [ion binding]; other site 138677001626 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 138677001627 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 138677001628 active site 138677001629 DNA binding site [nucleotide binding] 138677001630 catalytic site [active] 138677001631 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 138677001632 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 138677001633 tandem repeat interface [polypeptide binding]; other site 138677001634 oligomer interface [polypeptide binding]; other site 138677001635 active site residues [active] 138677001636 ADP/ATP carrier protein family; Region: AAA; TIGR00769 138677001637 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 138677001638 replicative DNA helicase; Provisional; Region: PRK06321 138677001639 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 138677001640 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 138677001641 Walker A motif; other site 138677001642 ATP binding site [chemical binding]; other site 138677001643 Walker B motif; other site 138677001644 DNA binding loops [nucleotide binding] 138677001645 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 138677001646 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 138677001647 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 138677001648 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 138677001649 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 138677001650 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 138677001651 active site 138677001652 multimer interface [polypeptide binding]; other site 138677001653 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 138677001654 RuvA N terminal domain; Region: RuvA_N; pfam01330 138677001655 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 138677001656 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 138677001657 active site 138677001658 putative DNA-binding cleft [nucleotide binding]; other site 138677001659 dimer interface [polypeptide binding]; other site 138677001660 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 138677001661 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 138677001662 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 138677001663 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 138677001664 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 138677001665 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 138677001666 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 138677001667 alphaNTD - beta interaction site [polypeptide binding]; other site 138677001668 alphaNTD homodimer interface [polypeptide binding]; other site 138677001669 alphaNTD - beta' interaction site [polypeptide binding]; other site 138677001670 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 138677001671 30S ribosomal protein S11; Validated; Region: PRK05309 138677001672 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 138677001673 30S ribosomal protein S13; Region: bact_S13; TIGR03631 138677001674 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 138677001675 SecY translocase; Region: SecY; pfam00344 138677001676 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 138677001677 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 138677001678 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 138677001679 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 138677001680 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 138677001681 5S rRNA interface [nucleotide binding]; other site 138677001682 23S rRNA interface [nucleotide binding]; other site 138677001683 L5 interface [polypeptide binding]; other site 138677001684 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 138677001685 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 138677001686 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 138677001687 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 138677001688 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 138677001689 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 138677001690 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 138677001691 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 138677001692 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 138677001693 RNA binding site [nucleotide binding]; other site 138677001694 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 138677001695 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 138677001696 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 138677001697 23S rRNA interface [nucleotide binding]; other site 138677001698 putative translocon interaction site; other site 138677001699 signal recognition particle (SRP54) interaction site; other site 138677001700 L23 interface [polypeptide binding]; other site 138677001701 trigger factor interaction site; other site 138677001702 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 138677001703 23S rRNA interface [nucleotide binding]; other site 138677001704 5S rRNA interface [nucleotide binding]; other site 138677001705 putative antibiotic binding site [chemical binding]; other site 138677001706 L25 interface [polypeptide binding]; other site 138677001707 L27 interface [polypeptide binding]; other site 138677001708 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 138677001709 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 138677001710 G-X-X-G motif; other site 138677001711 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 138677001712 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 138677001713 putative translocon binding site; other site 138677001714 protein-rRNA interface [nucleotide binding]; other site 138677001715 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 138677001716 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 138677001717 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 138677001718 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 138677001719 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 138677001720 Ribosomal protein L4 [Translation, ribosomal structure and biogenesis]; Region: RplD; COG0088 138677001721 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 138677001722 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 138677001723 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 138677001724 putative active site [active] 138677001725 substrate binding site [chemical binding]; other site 138677001726 putative cosubstrate binding site; other site 138677001727 catalytic site [active] 138677001728 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 138677001729 substrate binding site [chemical binding]; other site 138677001730 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 138677001731 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 138677001732 active site 138677001733 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 138677001734 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 138677001735 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 138677001736 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 138677001737 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 138677001738 putative active site [active] 138677001739 catalytic triad [active] 138677001740 putative dimer interface [polypeptide binding]; other site 138677001741 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 138677001742 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 138677001743 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 138677001744 active site 138677001745 catalytic site [active] 138677001746 substrate binding site [chemical binding]; other site 138677001747 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 138677001748 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 138677001749 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 138677001750 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 138677001751 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 138677001752 catalytic residues [active] 138677001753 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 138677001754 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 138677001755 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 138677001756 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 138677001757 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 138677001758 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 138677001759 dimer interface [polypeptide binding]; other site 138677001760 anticodon binding site; other site 138677001761 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 138677001762 homodimer interface [polypeptide binding]; other site 138677001763 motif 1; other site 138677001764 active site 138677001765 motif 2; other site 138677001766 GAD domain; Region: GAD; pfam02938 138677001767 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 138677001768 active site 138677001769 motif 3; other site 138677001770 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 138677001771 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 138677001772 dimer interface [polypeptide binding]; other site 138677001773 motif 1; other site 138677001774 active site 138677001775 motif 2; other site 138677001776 motif 3; other site 138677001777 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 138677001778 anticodon binding site; other site 138677001779 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 138677001780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 138677001781 putative substrate translocation pore; other site 138677001782 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 138677001783 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 138677001784 active site 138677001785 PHP Thumb interface [polypeptide binding]; other site 138677001786 metal binding site [ion binding]; metal-binding site 138677001787 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 138677001788 generic binding surface I; other site 138677001789 generic binding surface II; other site 138677001790 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 138677001791 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 138677001792 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 138677001793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 138677001794 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 138677001795 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 138677001796 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 138677001797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 138677001798 S-adenosylmethionine binding site [chemical binding]; other site 138677001799 Phosphoglycerate kinase; Region: PGK; pfam00162 138677001800 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 138677001801 substrate binding site [chemical binding]; other site 138677001802 hinge regions; other site 138677001803 ADP binding site [chemical binding]; other site 138677001804 catalytic site [active] 138677001805 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 138677001806 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 138677001807 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 138677001808 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 138677001809 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 138677001810 Walker A/P-loop; other site 138677001811 ATP binding site [chemical binding]; other site 138677001812 Q-loop/lid; other site 138677001813 ABC transporter signature motif; other site 138677001814 Walker B; other site 138677001815 D-loop; other site 138677001816 H-loop/switch region; other site 138677001817 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 138677001818 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 138677001819 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 138677001820 Walker A/P-loop; other site 138677001821 ATP binding site [chemical binding]; other site 138677001822 Q-loop/lid; other site 138677001823 ABC transporter signature motif; other site 138677001824 Walker B; other site 138677001825 D-loop; other site 138677001826 H-loop/switch region; other site 138677001827 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 138677001828 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 138677001829 ParB-like nuclease domain; Region: ParBc; pfam02195 138677001830 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 138677001831 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 138677001832 putative active site [active] 138677001833 putative metal binding site [ion binding]; other site 138677001834 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 138677001835 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 138677001836 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 138677001837 catalytic residue [active] 138677001838 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 138677001839 FeS assembly protein SufD; Region: sufD; TIGR01981 138677001840 FeS assembly ATPase SufC; Region: sufC; TIGR01978 138677001841 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 138677001842 Walker A/P-loop; other site 138677001843 ATP binding site [chemical binding]; other site 138677001844 Q-loop/lid; other site 138677001845 ABC transporter signature motif; other site 138677001846 Walker B; other site 138677001847 D-loop; other site 138677001848 H-loop/switch region; other site 138677001849 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 138677001850 putative ABC transporter; Region: ycf24; CHL00085 138677001851 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 138677001852 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 138677001853 binding surface 138677001854 TPR motif; other site 138677001855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 138677001856 binding surface 138677001857 TPR motif; other site 138677001858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 138677001859 binding surface 138677001860 TPR motif; other site 138677001861 TPR repeat; Region: TPR_11; pfam13414 138677001862 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 138677001863 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 138677001864 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 138677001865 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 138677001866 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 138677001867 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 138677001868 rRNA interaction site [nucleotide binding]; other site 138677001869 S8 interaction site; other site 138677001870 putative laminin-1 binding site; other site 138677001871 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 138677001872 UBA/TS-N domain; Region: UBA; pfam00627 138677001873 Elongation factor TS; Region: EF_TS; pfam00889 138677001874 Elongation factor TS; Region: EF_TS; pfam00889 138677001875 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 138677001876 putative nucleotide binding site [chemical binding]; other site 138677001877 uridine monophosphate binding site [chemical binding]; other site 138677001878 homohexameric interface [polypeptide binding]; other site 138677001879 ribosome recycling factor; Reviewed; Region: frr; PRK00083 138677001880 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 138677001881 hinge region; other site 138677001882 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 138677001883 UvrB/uvrC motif; Region: UVR; pfam02151 138677001884 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 138677001885 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 138677001886 ADP binding site [chemical binding]; other site 138677001887 phosphagen binding site; other site 138677001888 substrate specificity loop; other site 138677001889 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 138677001890 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 138677001891 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 138677001892 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 138677001893 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 138677001894 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 138677001895 Catalytic domain of Protein Kinases; Region: PKc; cd00180 138677001896 active site 138677001897 ATP binding site [chemical binding]; other site 138677001898 substrate binding site [chemical binding]; other site 138677001899 activation loop (A-loop); other site 138677001900 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 138677001901 type III secretion system protein; Validated; Region: PRK05933 138677001902 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 138677001903 type III secretion system ATPase; Provisional; Region: PRK06315 138677001904 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 138677001905 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 138677001906 Walker A motif/ATP binding site; other site 138677001907 Walker B motif; other site 138677001908 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 138677001909 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 138677001910 phosphopeptide binding site; other site 138677001911 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 138677001912 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 138677001913 phosphopeptide binding site; other site 138677001914 bacterial OsmY and nodulation domain; Region: BON; smart00749 138677001915 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 138677001916 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 138677001917 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 138677001918 NAD(P) binding pocket [chemical binding]; other site 138677001919 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 138677001920 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 138677001921 ATP binding site [chemical binding]; other site 138677001922 Mg2+ binding site [ion binding]; other site 138677001923 G-X-G motif; other site 138677001924 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 138677001925 anchoring element; other site 138677001926 dimer interface [polypeptide binding]; other site 138677001927 ATP binding site [chemical binding]; other site 138677001928 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 138677001929 active site 138677001930 putative metal-binding site [ion binding]; other site 138677001931 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 138677001932 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 138677001933 CAP-like domain; other site 138677001934 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 138677001935 active site 138677001936 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 138677001937 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 138677001938 RNA binding surface [nucleotide binding]; other site 138677001939 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 138677001940 active site 138677001941 hypothetical protein; Provisional; Region: PRK01064 138677001942 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 138677001943 G-X-X-G motif; other site 138677001944 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 138677001945 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 138677001946 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 138677001947 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 138677001948 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 138677001949 Walker A/P-loop; other site 138677001950 ATP binding site [chemical binding]; other site 138677001951 Q-loop/lid; other site 138677001952 ABC transporter signature motif; other site 138677001953 Walker B; other site 138677001954 D-loop; other site 138677001955 H-loop/switch region; other site 138677001956 6-phosphogluconate dehydrogenase; Provisional; Region: PTZ00142 138677001957 Effector from type III secretion system; Region: Effector_1; pfam04518 138677001958 Effector from type III secretion system; Region: Effector_1; pfam04518 138677001959 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 138677001960 MviN-like protein; Region: MVIN; pfam03023 138677001961 AP endonuclease family 2; Region: AP2Ec; smart00518 138677001962 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 138677001963 AP (apurinic/apyrimidinic) site pocket; other site 138677001964 DNA interaction; other site 138677001965 Metal-binding active site; metal-binding site 138677001966 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 138677001967 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 138677001968 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 138677001969 RNA binding surface [nucleotide binding]; other site 138677001970 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 138677001971 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 138677001972 active site residue [active] 138677001973 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 138677001974 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 138677001975 ATP-binding site [chemical binding]; other site 138677001976 Sugar specificity; other site 138677001977 Pyrimidine base specificity; other site 138677001978 H+ Antiporter protein; Region: 2A0121; TIGR00900 138677001979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 138677001980 putative substrate translocation pore; other site 138677001981 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 138677001982 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 138677001983 Family description; Region: UvrD_C_2; pfam13538 138677001984 rod shape-determining protein MreC; Provisional; Region: PRK14872 138677001985 rod shape-determining protein MreC; Region: MreC; pfam04085 138677001986 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 138677001987 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 138677001988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 138677001989 homodimer interface [polypeptide binding]; other site 138677001990 catalytic residue [active] 138677001991 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 138677001992 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 138677001993 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 138677001994 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA [Energy production and conversion]; Region: NqrA; COG1726 138677001995 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 138677001996 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 138677001997 dimer interface [polypeptide binding]; other site 138677001998 allosteric magnesium binding site [ion binding]; other site 138677001999 active site 138677002000 aspartate-rich active site metal binding site; other site 138677002001 Schiff base residues; other site 138677002002 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 138677002003 Thymidylate synthase complementing protein; Region: Thy1; cl03630 138677002004 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 138677002005 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 138677002006 substrate binding pocket [chemical binding]; other site 138677002007 chain length determination region; other site 138677002008 substrate-Mg2+ binding site; other site 138677002009 catalytic residues [active] 138677002010 aspartate-rich region 1; other site 138677002011 active site lid residues [active] 138677002012 aspartate-rich region 2; other site 138677002013 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 138677002014 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 138677002015 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 138677002016 DNA binding site [nucleotide binding] 138677002017 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 138677002018 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 138677002019 AAA domain; Region: AAA_30; pfam13604 138677002020 Family description; Region: UvrD_C_2; pfam13538 138677002021 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 138677002022 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 138677002023 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 138677002024 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 138677002025 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 138677002026 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 138677002027 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 138677002028 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 138677002029 DNA binding residues [nucleotide binding] 138677002030 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 138677002031 homooctamer interface [polypeptide binding]; other site 138677002032 active site 138677002033 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 138677002034 catalytic center binding site [active] 138677002035 ATP binding site [chemical binding]; other site 138677002036 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 138677002037 dihydropteroate synthase; Region: DHPS; TIGR01496 138677002038 substrate binding pocket [chemical binding]; other site 138677002039 dimer interface [polypeptide binding]; other site 138677002040 inhibitor binding site; inhibition site 138677002041 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 138677002042 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 138677002043 folate binding site [chemical binding]; other site 138677002044 NADP+ binding site [chemical binding]; other site 138677002045 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 138677002046 putative folate metabolism gamma-glutamate ligase; Region: intra_fol_E_lig; TIGR04132 138677002047 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 138677002048 recombinase A; Provisional; Region: recA; PRK09354 138677002049 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 138677002050 hexamer interface [polypeptide binding]; other site 138677002051 Walker A motif; other site 138677002052 ATP binding site [chemical binding]; other site 138677002053 Walker B motif; other site 138677002054 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 138677002055 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 138677002056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 138677002057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 138677002058 YGGT family; Region: YGGT; pfam02325 138677002059 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 138677002060 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 138677002061 FMN binding site [chemical binding]; other site 138677002062 active site 138677002063 catalytic residues [active] 138677002064 substrate binding site [chemical binding]; other site 138677002065 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 138677002066 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 138677002067 active site 138677002068 interdomain interaction site; other site 138677002069 putative metal-binding site [ion binding]; other site 138677002070 nucleotide binding site [chemical binding]; other site 138677002071 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 138677002072 domain I; other site 138677002073 DNA binding groove [nucleotide binding] 138677002074 phosphate binding site [ion binding]; other site 138677002075 domain II; other site 138677002076 domain III; other site 138677002077 nucleotide binding site [chemical binding]; other site 138677002078 catalytic site [active] 138677002079 domain IV; other site 138677002080 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 138677002081 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 138677002082 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 138677002083 SWIB/MDM2 domain; Region: SWIB; pfam02201 138677002084 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 138677002085 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 138677002086 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 138677002087 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 138677002088 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 138677002089 Part of AAA domain; Region: AAA_19; pfam13245 138677002090 Family description; Region: UvrD_C_2; pfam13538 138677002091 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 138677002092 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 138677002093 ligand binding site [chemical binding]; other site 138677002094 active site 138677002095 UGI interface [polypeptide binding]; other site 138677002096 catalytic site [active] 138677002097 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 138677002098 active site 138677002099 dimerization interface [polypeptide binding]; other site 138677002100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 138677002101 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 138677002102 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 138677002103 ring oligomerisation interface [polypeptide binding]; other site 138677002104 ATP/Mg binding site [chemical binding]; other site 138677002105 stacking interactions; other site 138677002106 hinge regions; other site 138677002107 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 138677002108 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 138677002109 dimer interface [polypeptide binding]; other site 138677002110 decamer (pentamer of dimers) interface [polypeptide binding]; other site 138677002111 catalytic triad [active] 138677002112 peroxidatic and resolving cysteines [active] 138677002113 Ependymin; Region: Ependymin; cl02428 138677002114 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 138677002115 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 138677002116 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 138677002117 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 138677002118 ligand binding site [chemical binding]; other site 138677002119 translocation protein TolB; Provisional; Region: tolB; PRK01029 138677002120 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 138677002121 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 138677002122 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 138677002123 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 138677002124 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 138677002125 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 138677002126 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 138677002127 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 138677002128 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 138677002129 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 138677002130 DsbD alpha interface [polypeptide binding]; other site 138677002131 catalytic residues [active] 138677002132 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 138677002133 active site 138677002134 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 138677002135 putative Iron-sulfur protein interface [polypeptide binding]; other site 138677002136 proximal heme binding site [chemical binding]; other site 138677002137 putative dimer interface [polypeptide binding]; other site 138677002138 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 138677002139 proximal heme binding site [chemical binding]; other site 138677002140 Iron-sulfur protein interface; other site 138677002141 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 138677002142 L-aspartate oxidase; Provisional; Region: PRK06175 138677002143 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 138677002144 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 138677002145 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 138677002146 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 138677002147 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 138677002148 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 138677002149 HAMP domain; Region: HAMP; pfam00672 138677002150 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 138677002151 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 138677002152 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 138677002153 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 138677002154 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677002155 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 138677002156 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 138677002157 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 138677002158 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677002159 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 138677002160 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 138677002161 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 138677002162 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 138677002163 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 138677002164 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 138677002165 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 138677002166 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 138677002167 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 138677002168 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 138677002169 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 138677002170 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 138677002171 enolase; Provisional; Region: eno; PRK00077 138677002172 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 138677002173 dimer interface [polypeptide binding]; other site 138677002174 metal binding site [ion binding]; metal-binding site 138677002175 substrate binding pocket [chemical binding]; other site 138677002176 excinuclease ABC subunit B; Provisional; Region: PRK05298 138677002177 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 138677002178 ATP binding site [chemical binding]; other site 138677002179 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 138677002180 nucleotide binding region [chemical binding]; other site 138677002181 ATP-binding site [chemical binding]; other site 138677002182 Ultra-violet resistance protein B; Region: UvrB; pfam12344 138677002183 UvrB/uvrC motif; Region: UVR; pfam02151 138677002184 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 138677002185 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 138677002186 active site 138677002187 HIGH motif; other site 138677002188 dimer interface [polypeptide binding]; other site 138677002189 KMSKS motif; other site 138677002190 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 138677002191 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 138677002192 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 138677002193 P-loop; other site 138677002194 Magnesium ion binding site [ion binding]; other site 138677002195 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 138677002196 Magnesium ion binding site [ion binding]; other site 138677002197 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 138677002198 TGS domain; Region: TGS; pfam02824 138677002199 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 138677002200 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 138677002201 active site 138677002202 dimer interface [polypeptide binding]; other site 138677002203 motif 1; other site 138677002204 motif 2; other site 138677002205 motif 3; other site 138677002206 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 138677002207 anticodon binding site; other site 138677002208 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 138677002209 EamA-like transporter family; Region: EamA; pfam00892 138677002210 EamA-like transporter family; Region: EamA; pfam00892 138677002211 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 138677002212 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 138677002213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 138677002214 binding surface 138677002215 TPR motif; other site 138677002216 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 138677002217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 138677002218 ATP binding site [chemical binding]; other site 138677002219 Mg2+ binding site [ion binding]; other site 138677002220 G-X-G motif; other site 138677002221 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 138677002222 ATP binding site [chemical binding]; other site 138677002223 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 138677002224 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 138677002225 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 138677002226 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 138677002227 active site 138677002228 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 138677002229 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 138677002230 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 138677002231 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 138677002232 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 138677002233 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 138677002234 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 138677002235 Walker A motif; other site 138677002236 ATP binding site [chemical binding]; other site 138677002237 Walker B motif; other site 138677002238 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 138677002239 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 138677002240 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 138677002241 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 138677002242 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 138677002243 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 138677002244 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 138677002245 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 138677002246 FliP family; Region: FliP; cl00593 138677002247 type III secretion system protein; Reviewed; Region: PRK09617 138677002248 type III secretion system protein; Validated; Region: PRK06328 138677002249 Flagellar assembly protein FliH; Region: FliH; pfam02108 138677002250 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 138677002251 Lipoate synthase [Coenzyme metabolism]; Region: LipA; COG0320 138677002252 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 138677002253 FeS/SAM binding site; other site 138677002254 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 138677002255 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 138677002256 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 138677002257 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 138677002258 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 138677002259 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 138677002260 ATP binding site [chemical binding]; other site 138677002261 putative Mg++ binding site [ion binding]; other site 138677002262 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 138677002263 nucleotide binding region [chemical binding]; other site 138677002264 ATP-binding site [chemical binding]; other site 138677002265 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 138677002266 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 138677002267 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 138677002268 minor groove reading motif; other site 138677002269 helix-hairpin-helix signature motif; other site 138677002270 substrate binding pocket [chemical binding]; other site 138677002271 active site 138677002272 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 138677002273 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 138677002274 trmE is a tRNA modification GTPase; Region: trmE; cd04164 138677002275 G1 box; other site 138677002276 GTP/Mg2+ binding site [chemical binding]; other site 138677002277 Switch I region; other site 138677002278 G2 box; other site 138677002279 Switch II region; other site 138677002280 G3 box; other site 138677002281 G4 box; other site 138677002282 G5 box; other site 138677002283 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 138677002284 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 138677002285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 138677002286 TPR motif; other site 138677002287 binding surface 138677002288 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 138677002289 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 138677002290 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 138677002291 nucleotide binding region [chemical binding]; other site 138677002292 ATP-binding site [chemical binding]; other site 138677002293 Predicted GTPases [General function prediction only]; Region: COG1160 138677002294 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 138677002295 G1 box; other site 138677002296 GTP/Mg2+ binding site [chemical binding]; other site 138677002297 Switch I region; other site 138677002298 G2 box; other site 138677002299 Switch II region; other site 138677002300 G3 box; other site 138677002301 G4 box; other site 138677002302 G5 box; other site 138677002303 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 138677002304 G1 box; other site 138677002305 GTP/Mg2+ binding site [chemical binding]; other site 138677002306 Switch I region; other site 138677002307 G2 box; other site 138677002308 G3 box; other site 138677002309 Switch II region; other site 138677002310 G4 box; other site 138677002311 G5 box; other site 138677002312 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 138677002313 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 138677002314 active site 138677002315 NTP binding site [chemical binding]; other site 138677002316 metal binding triad [ion binding]; metal-binding site 138677002317 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 138677002318 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 138677002319 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 138677002320 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 138677002321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 138677002322 Walker A motif; other site 138677002323 ATP binding site [chemical binding]; other site 138677002324 Walker B motif; other site 138677002325 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 138677002326 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 138677002327 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 138677002328 oligomer interface [polypeptide binding]; other site 138677002329 active site residues [active] 138677002330 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 138677002331 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 138677002332 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 138677002333 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 138677002334 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 138677002335 ATP binding site [chemical binding]; other site 138677002336 putative Mg++ binding site [ion binding]; other site 138677002337 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 138677002338 nucleotide binding region [chemical binding]; other site 138677002339 ATP-binding site [chemical binding]; other site 138677002340 rod shape-determining protein MreB; Provisional; Region: PRK13927 138677002341 MreB and similar proteins; Region: MreB_like; cd10225 138677002342 nucleotide binding site [chemical binding]; other site 138677002343 Mg binding site [ion binding]; other site 138677002344 putative protofilament interaction site [polypeptide binding]; other site 138677002345 RodZ interaction site [polypeptide binding]; other site 138677002346 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 138677002347 active site 138677002348 substrate-binding site [chemical binding]; other site 138677002349 metal-binding site [ion binding] 138677002350 GTP binding site [chemical binding]; other site 138677002351 Effector from type III secretion system; Region: Effector_1; pfam04518 138677002352 Effector from type III secretion system; Region: Effector_1; pfam04518 138677002353 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 138677002354 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 138677002355 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 138677002356 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 138677002357 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 138677002358 substrate binding site; other site 138677002359 dimerization interface; other site 138677002360 type III secretion system ATPase; Validated; Region: PRK05922 138677002361 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 138677002362 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 138677002363 Walker A motif; other site 138677002364 ATP binding site [chemical binding]; other site 138677002365 Walker B motif; other site 138677002366 Flagellar assembly protein FliH; Region: FliH; pfam02108 138677002367 type III secretion system protein; Validated; Region: PRK05934 138677002368 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 138677002369 MgtE intracellular N domain; Region: MgtE_N; cl15244 138677002370 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 138677002371 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 138677002372 trimerization site [polypeptide binding]; other site 138677002373 active site 138677002374 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 138677002375 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 138677002376 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 138677002377 catalytic residue [active] 138677002378 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 138677002379 catalytic core [active] 138677002380 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 138677002381 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 138677002382 RNA binding surface [nucleotide binding]; other site 138677002383 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 138677002384 active site 138677002385 biotin--protein ligase; Provisional; Region: PRK05935 138677002386 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 138677002387 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 138677002388 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 138677002389 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 138677002390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 138677002391 motif II; other site 138677002392 CCC1-related protein family; Region: CCC1_like_1; cd02437 138677002393 seryl-tRNA synthetase; Provisional; Region: PRK05431 138677002394 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 138677002395 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 138677002396 dimer interface [polypeptide binding]; other site 138677002397 active site 138677002398 motif 1; other site 138677002399 motif 2; other site 138677002400 motif 3; other site 138677002401 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 138677002402 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 138677002403 catalytic motif [active] 138677002404 Zn binding site [ion binding]; other site 138677002405 RibD C-terminal domain; Region: RibD_C; cl17279 138677002406 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 138677002407 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 138677002408 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 138677002409 dimerization interface [polypeptide binding]; other site 138677002410 active site 138677002411 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 138677002412 homopentamer interface [polypeptide binding]; other site 138677002413 active site 138677002414 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 138677002415 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 138677002416 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 138677002417 substrate binding site [chemical binding]; other site 138677002418 Proteins containing SET domain [General function prediction only]; Region: COG2940 138677002419 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 138677002420 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 138677002421 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 138677002422 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 138677002423 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 138677002424 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 138677002425 Protein of unknown function (DUF687); Region: DUF687; pfam05095 138677002426 Protein of unknown function (DUF687); Region: DUF687; pfam05095 138677002427 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 138677002428 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 138677002429 catalytic loop [active] 138677002430 iron binding site [ion binding]; other site 138677002431 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 138677002432 FAD binding pocket [chemical binding]; other site 138677002433 FAD binding motif [chemical binding]; other site 138677002434 phosphate binding motif [ion binding]; other site 138677002435 beta-alpha-beta structure motif; other site 138677002436 NAD binding pocket [chemical binding]; other site 138677002437 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 138677002438 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 138677002439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 138677002440 S-adenosylmethionine binding site [chemical binding]; other site 138677002441 Histone H1-like protein Hc1; Region: Hc1; pfam07432 138677002442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 138677002443 binding surface 138677002444 TPR motif; other site 138677002445 Tetratricopeptide repeat; Region: TPR_12; pfam13424 138677002446 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 138677002447 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 138677002448 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 138677002449 HemN C-terminal domain; Region: HemN_C; pfam06969 138677002450 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 138677002451 substrate binding site [chemical binding]; other site 138677002452 active site 138677002453 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 138677002454 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 138677002455 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 138677002456 ATP binding site [chemical binding]; other site 138677002457 putative Mg++ binding site [ion binding]; other site 138677002458 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 138677002459 nucleotide binding region [chemical binding]; other site 138677002460 ATP-binding site [chemical binding]; other site 138677002461 TRCF domain; Region: TRCF; pfam03461 138677002462 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 138677002463 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 138677002464 motif 1; other site 138677002465 active site 138677002466 motif 2; other site 138677002467 motif 3; other site 138677002468 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 138677002469 DHHA1 domain; Region: DHHA1; pfam02272 138677002470 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 138677002471 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 138677002472 TPP-binding site [chemical binding]; other site 138677002473 dimer interface [polypeptide binding]; other site 138677002474 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 138677002475 PYR/PP interface [polypeptide binding]; other site 138677002476 dimer interface [polypeptide binding]; other site 138677002477 TPP binding site [chemical binding]; other site 138677002478 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 138677002479 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 138677002480 elongation factor P; Validated; Region: PRK00529 138677002481 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 138677002482 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 138677002483 RNA binding site [nucleotide binding]; other site 138677002484 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 138677002485 RNA binding site [nucleotide binding]; other site 138677002486 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 138677002487 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 138677002488 putative active site [active] 138677002489 putative metal binding site [ion binding]; other site 138677002490 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 138677002491 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 138677002492 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 138677002493 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 138677002494 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 138677002495 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 138677002496 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 138677002497 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 138677002498 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 138677002499 Mg++ binding site [ion binding]; other site 138677002500 putative catalytic motif [active] 138677002501 putative substrate binding site [chemical binding]; other site 138677002502 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 138677002503 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 138677002504 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 138677002505 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 138677002506 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 138677002507 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 138677002508 cell division protein FtsW; Region: ftsW; TIGR02614 138677002509 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 138677002510 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 138677002511 active site 138677002512 homodimer interface [polypeptide binding]; other site 138677002513 bifunctional D-alanyl-alanine synthetase A/UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: PRK14573 138677002514 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 138677002515 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 138677002516 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 138677002517 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 138677002518 ATP-grasp domain; Region: ATP-grasp_4; cl17255 138677002519 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 138677002520 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409 138677002521 G-X-X-G motif; other site 138677002522 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 138677002523 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 138677002524 anti sigma factor interaction site; other site 138677002525 regulatory phosphorylation site [posttranslational modification]; other site 138677002526 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 138677002527 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 138677002528 hypothetical protein; Provisional; Region: PRK05927 138677002529 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 138677002530 FeS/SAM binding site; other site 138677002531 Cytochrome c552; Region: Cytochrom_C552; pfam02335 138677002532 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 138677002533 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 138677002534 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 138677002535 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 138677002536 dimer interface [polypeptide binding]; other site 138677002537 active site 138677002538 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 138677002539 active site 138677002540 Ap4A binding cleft/pocket [chemical binding]; other site 138677002541 P4 phosphate binding site; other site 138677002542 nudix motif; other site 138677002543 putative P2/P3 phosphate binding site [ion binding]; other site 138677002544 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 138677002545 dimer interface [polypeptide binding]; other site 138677002546 substrate binding site [chemical binding]; other site 138677002547 metal binding sites [ion binding]; metal-binding site 138677002548 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 138677002549 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 138677002550 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 138677002551 NAD binding site [chemical binding]; other site 138677002552 Phe binding site; other site 138677002553 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 138677002554 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 138677002555 active site 138677002556 putative lithium-binding site [ion binding]; other site 138677002557 substrate binding site [chemical binding]; other site 138677002558 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 138677002559 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 138677002560 putative acyl-acceptor binding pocket; other site 138677002561 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 138677002562 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 138677002563 acyl-activating enzyme (AAE) consensus motif; other site 138677002564 putative AMP binding site [chemical binding]; other site 138677002565 8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937 138677002566 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 138677002567 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 138677002568 catalytic residue [active] 138677002569 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 138677002570 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 138677002571 ATP binding site [chemical binding]; other site 138677002572 putative Mg++ binding site [ion binding]; other site 138677002573 helicase superfamily c-terminal domain; Region: HELICc; smart00490 138677002574 ATP-binding site [chemical binding]; other site 138677002575 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 138677002576 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 138677002577 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 138677002578 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 138677002579 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 138677002580 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 138677002581 Lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: LysU; COG1190 138677002582 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 138677002583 dimer interface [polypeptide binding]; other site 138677002584 putative anticodon binding site; other site 138677002585 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 138677002586 motif 1; other site 138677002587 dimer interface [polypeptide binding]; other site 138677002588 active site 138677002589 motif 2; other site 138677002590 motif 3; other site 138677002591 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 138677002592 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 138677002593 active site 138677002594 HIGH motif; other site 138677002595 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 138677002596 KMSKS motif; other site 138677002597 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 138677002598 anticodon binding site; other site 138677002599 tRNA binding surface [nucleotide binding]; other site 138677002600 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 138677002601 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 138677002602 ribonuclease P; Reviewed; Region: rnpA; PRK00730 138677002603 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 138677002604 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 138677002605 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 138677002606 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 138677002607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 138677002608 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 138677002609 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 138677002610 GIY-YIG motif/motif A; other site 138677002611 active site 138677002612 catalytic site [active] 138677002613 putative DNA binding site [nucleotide binding]; other site 138677002614 metal binding site [ion binding]; metal-binding site 138677002615 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 138677002616 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 138677002617 MutS domain I; Region: MutS_I; pfam01624 138677002618 MutS domain II; Region: MutS_II; pfam05188 138677002619 MutS domain III; Region: MutS_III; pfam05192 138677002620 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 138677002621 Walker A/P-loop; other site 138677002622 ATP binding site [chemical binding]; other site 138677002623 Q-loop/lid; other site 138677002624 ABC transporter signature motif; other site 138677002625 Walker B; other site 138677002626 D-loop; other site 138677002627 H-loop/switch region; other site 138677002628 DNA primase; Validated; Region: dnaG; PRK05667 138677002629 CHC2 zinc finger; Region: zf-CHC2; pfam01807 138677002630 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 138677002631 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 138677002632 active site 138677002633 metal binding site [ion binding]; metal-binding site 138677002634 interdomain interaction site; other site 138677002635 glycyl-tRNA synthetase; Provisional; Region: PRK14908 138677002636 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 138677002637 dimer interface [polypeptide binding]; other site 138677002638 motif 1; other site 138677002639 active site 138677002640 motif 2; other site 138677002641 motif 3; other site 138677002642 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 138677002643 glycogen synthase; Provisional; Region: glgA; PRK00654 138677002644 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 138677002645 ADP-binding pocket [chemical binding]; other site 138677002646 homodimer interface [polypeptide binding]; other site 138677002647 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 138677002648 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 138677002649 5S rRNA interface [nucleotide binding]; other site 138677002650 CTC domain interface [polypeptide binding]; other site 138677002651 L16 interface [polypeptide binding]; other site 138677002652 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 138677002653 putative active site [active] 138677002654 catalytic residue [active] 138677002655 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 138677002656 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 138677002657 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 138677002658 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 138677002659 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 138677002660 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 138677002661 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK00650 138677002662 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 138677002663 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 138677002664 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 138677002665 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 138677002666 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 138677002667 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT; Region: LPLAT_GPAT; cd07985 138677002668 putative G3P-binding pocket; other site 138677002669 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 138677002670 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 138677002671 homodimer interface [polypeptide binding]; other site 138677002672 oligonucleotide binding site [chemical binding]; other site 138677002673 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 138677002674 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 138677002675 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 138677002676 Autotransporter beta-domain; Region: Autotransporter; pfam03797 138677002677 Domain of Unknown Function (DUF1539); Region: DUF1539; pfam07560 138677002678 Domain of Unknown Function (DUF1548); Region: DUF1548; pfam07579 138677002679 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 138677002680 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 138677002681 Predicted membrane protein [Function unknown]; Region: COG3952 138677002682 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 138677002683 poly(A) polymerase; Region: pcnB; TIGR01942 138677002684 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 138677002685 active site 138677002686 NTP binding site [chemical binding]; other site 138677002687 metal binding triad [ion binding]; metal-binding site 138677002688 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 138677002689 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 138677002690 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 138677002691 active site 138677002692 substrate binding site [chemical binding]; other site 138677002693 metal binding site [ion binding]; metal-binding site 138677002694 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 138677002695 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 138677002696 glutaminase active site [active] 138677002697 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 138677002698 dimer interface [polypeptide binding]; other site 138677002699 active site 138677002700 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 138677002701 dimer interface [polypeptide binding]; other site 138677002702 active site 138677002703 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 138677002704 aromatic amino acid transport protein; Region: araaP; TIGR00837 138677002705 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 138677002706 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 138677002707 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 138677002708 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 138677002709 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 138677002710 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 138677002711 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 138677002712 CoA-ligase; Region: Ligase_CoA; pfam00549 138677002713 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 138677002714 CoA binding domain; Region: CoA_binding; smart00881 138677002715 CoA-ligase; Region: Ligase_CoA; pfam00549 138677002716 Family of unknown function (DUF648); Region: DUF648; pfam04890 138677002717 Family of unknown function (DUF648); Region: DUF648; pfam04890 138677002718 Family of unknown function (DUF648); Region: DUF648; pfam04890 138677002719 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 138677002720 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 138677002721 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 138677002722 protein binding site [polypeptide binding]; other site 138677002723 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 138677002724 protein binding site [polypeptide binding]; other site 138677002725 hypothetical protein; Provisional; Region: PRK08201 138677002726 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 138677002727 metal binding site [ion binding]; metal-binding site 138677002728 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 138677002729 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 138677002730 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 138677002731 Peptidase M16C associated; Region: M16C_assoc; pfam08367 138677002732 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 138677002733 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 138677002734 RmuC family; Region: RmuC; pfam02646 138677002735 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 138677002736 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 138677002737 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 138677002738 ATP cone domain; Region: ATP-cone; pfam03477 138677002739 ATP cone domain; Region: ATP-cone; pfam03477 138677002740 Class I ribonucleotide reductase; Region: RNR_I; cd01679 138677002741 active site 138677002742 dimer interface [polypeptide binding]; other site 138677002743 catalytic residues [active] 138677002744 effector binding site; other site 138677002745 R2 peptide binding site; other site 138677002746 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 138677002747 dimer interface [polypeptide binding]; other site 138677002748 putative radical transfer pathway; other site 138677002749 diiron center [ion binding]; other site 138677002750 tyrosyl radical; other site 138677002751 Putative methyltransferase; Region: Methyltransf_4; pfam02390 138677002752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 138677002753 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 138677002754 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 138677002755 FAD binding domain; Region: FAD_binding_4; pfam01565 138677002756 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 138677002757 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 138677002758 putative RNA binding site [nucleotide binding]; other site 138677002759 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 138677002760 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 138677002761 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 138677002762 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 138677002763 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 138677002764 23S rRNA binding site [nucleotide binding]; other site 138677002765 L21 binding site [polypeptide binding]; other site 138677002766 L13 binding site [polypeptide binding]; other site 138677002767 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 138677002768 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 138677002769 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 138677002770 dimer interface [polypeptide binding]; other site 138677002771 motif 1; other site 138677002772 active site 138677002773 motif 2; other site 138677002774 motif 3; other site 138677002775 Predicted permeases [General function prediction only]; Region: COG0795 138677002776 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 138677002777 Predicted permeases [General function prediction only]; Region: COG0795 138677002778 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 138677002779 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 138677002780 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 138677002781 Ligand Binding Site [chemical binding]; other site 138677002782 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 138677002783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 138677002784 Walker A motif; other site 138677002785 ATP binding site [chemical binding]; other site 138677002786 Walker B motif; other site 138677002787 arginine finger; other site 138677002788 Peptidase family M41; Region: Peptidase_M41; pfam01434 138677002789 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 138677002790 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 138677002791 oligomer interface [polypeptide binding]; other site 138677002792 RNA binding site [nucleotide binding]; other site 138677002793 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 138677002794 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 138677002795 RNase E interface [polypeptide binding]; other site 138677002796 trimer interface [polypeptide binding]; other site 138677002797 active site 138677002798 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 138677002799 putative nucleic acid binding region [nucleotide binding]; other site 138677002800 G-X-X-G motif; other site 138677002801 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 138677002802 RNA binding site [nucleotide binding]; other site 138677002803 domain interface; other site 138677002804 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 138677002805 16S/18S rRNA binding site [nucleotide binding]; other site 138677002806 S13e-L30e interaction site [polypeptide binding]; other site 138677002807 25S rRNA binding site [nucleotide binding]; other site 138677002808 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 138677002809 nucleoside/Zn binding site; other site 138677002810 dimer interface [polypeptide binding]; other site 138677002811 catalytic motif [active] 138677002812 Protein of unknown function (DUF720); Region: DUF720; pfam05302 138677002813 Protein of unknown function (DUF720); Region: DUF720; pfam05302 138677002814 Protein of unknown function (DUF720); Region: DUF720; pfam05302 138677002815 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 138677002816 methionine aminopeptidase; Provisional; Region: PRK12318 138677002817 SEC-C motif; Region: SEC-C; pfam02810 138677002818 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 138677002819 active site 138677002820 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 138677002821 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 138677002822 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 138677002823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 138677002824 dimer interface [polypeptide binding]; other site 138677002825 conserved gate region; other site 138677002826 putative PBP binding loops; other site 138677002827 ABC-ATPase subunit interface; other site 138677002828 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 138677002829 NMT1/THI5 like; Region: NMT1; pfam09084 138677002830 fumarate hydratase, class II; Region: fumC_II; TIGR00979 138677002831 Class II fumarases; Region: Fumarase_classII; cd01362 138677002832 active site 138677002833 tetramer interface [polypeptide binding]; other site 138677002834 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 138677002835 Sulfate transporter family; Region: Sulfate_transp; pfam00916 138677002836 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 138677002837 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 138677002838 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 138677002839 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 138677002840 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 138677002841 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 138677002842 active site triad [active] 138677002843 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 138677002844 LytB protein; Region: LYTB; pfam02401 138677002845 Histone methylation protein DOT1; Region: DOT1; pfam08123 138677002846 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 138677002847 Tetratricopeptide repeat; Region: TPR_3; pfam07720 138677002848 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 138677002849 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 138677002850 active site 138677002851 Int/Topo IB signature motif; other site 138677002852 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 138677002853 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 138677002854 active site 138677002855 dimer interface [polypeptide binding]; other site 138677002856 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 138677002857 dimer interface [polypeptide binding]; other site 138677002858 active site 138677002859 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 138677002860 malate dehydrogenase; Provisional; Region: PRK05442 138677002861 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 138677002862 NAD(P) binding site [chemical binding]; other site 138677002863 dimer interface [polypeptide binding]; other site 138677002864 malate binding site [chemical binding]; other site 138677002865 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 138677002866 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 138677002867 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 138677002868 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 138677002869 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 138677002870 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 138677002871 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 138677002872 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 138677002873 active site 138677002874 catalytic residue [active] 138677002875 dimer interface [polypeptide binding]; other site 138677002876 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 138677002877 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 138677002878 shikimate binding site; other site 138677002879 NAD(P) binding site [chemical binding]; other site 138677002880 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 138677002881 active site 138677002882 dimer interface [polypeptide binding]; other site 138677002883 metal binding site [ion binding]; metal-binding site 138677002884 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 138677002885 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 138677002886 Tetramer interface [polypeptide binding]; other site 138677002887 active site 138677002888 FMN-binding site [chemical binding]; other site 138677002889 shikimate kinase; Provisional; Region: PRK00625 138677002890 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 138677002891 ADP binding site [chemical binding]; other site 138677002892 magnesium binding site [ion binding]; other site 138677002893 putative shikimate binding site; other site 138677002894 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 138677002895 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 138677002896 hinge; other site 138677002897 active site 138677002898 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 138677002899 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 138677002900 inhibitor-cofactor binding pocket; inhibition site 138677002901 pyridoxal 5'-phosphate binding site [chemical binding]; other site 138677002902 catalytic residue [active] 138677002903 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 138677002904 AAA domain; Region: AAA_26; pfam13500 138677002905 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 138677002906 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 138677002907 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 138677002908 catalytic residue [active] 138677002909 Biotin synthase and related enzymes [Coenzyme metabolism]; Region: BioB; COG0502 138677002910 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 138677002911 FeS/SAM binding site; other site 138677002912 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 138677002913 conserved hypothetical integral membrane protein; Region: TIGR00697 138677002914 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 138677002915 cofactor binding site; other site 138677002916 metal binding site [ion binding]; metal-binding site 138677002917 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 138677002918 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 138677002919 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 138677002920 aspartate-semialdehyde dehydrogenase (non-peptidoglycan organisms); Region: asd_EA; TIGR00978 138677002921 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 138677002922 aspartate kinase; Provisional; Region: PRK05925 138677002923 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 138677002924 putative catalytic residues [active] 138677002925 nucleotide binding site [chemical binding]; other site 138677002926 aspartate binding site [chemical binding]; other site 138677002927 dihydrodipicolinate synthase; Provisional; Region: PRK03170 138677002928 dihydrodipicolinate synthase; Region: dapA; TIGR00674 138677002929 catalytic residue [active] 138677002930 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 138677002931 IncA protein; Region: IncA; pfam04156 138677002932 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 138677002933 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 138677002934 catalytic residues [active] 138677002935 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 138677002936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 138677002937 S-adenosylmethionine binding site [chemical binding]; other site 138677002938 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 138677002939 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 138677002940 TPP-binding site; other site 138677002941 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 138677002942 PYR/PP interface [polypeptide binding]; other site 138677002943 dimer interface [polypeptide binding]; other site 138677002944 TPP binding site [chemical binding]; other site 138677002945 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 138677002946 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 138677002947 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 138677002948 generic binding surface II; other site 138677002949 generic binding surface I; other site 138677002950 triosephosphate isomerase; Provisional; Region: PRK14567 138677002951 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 138677002952 substrate binding site [chemical binding]; other site 138677002953 dimer interface [polypeptide binding]; other site 138677002954 catalytic triad [active] 138677002955 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 138677002956 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 138677002957 active site 138677002958 catalytic residues [active] 138677002959 metal binding site [ion binding]; metal-binding site 138677002960 ribonuclease HIII; Provisional; Region: PRK00996 138677002961 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 138677002962 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 138677002963 RNA/DNA hybrid binding site [nucleotide binding]; other site 138677002964 active site 138677002965 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 138677002966 Helix-turn-helix domain; Region: HTH_25; pfam13413 138677002967 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 138677002968 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019