-- dump date 20140619_040046 -- class Genbank::misc_feature -- table misc_feature_note -- id note 813000001 Uncharacterized conserved protein [Function unknown]; Region: COG2155 813000002 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 813000003 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 813000004 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 813000005 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 813000006 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 813000007 GatB domain; Region: GatB_Yqey; pfam02637 813000008 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 813000009 ribonuclease HIII; Region: rnhC; TIGR00716 813000010 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 813000011 RNA/DNA hybrid binding site [nucleotide binding]; other site 813000012 active site 813000013 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 813000014 Helix-turn-helix domain; Region: HTH_25; pfam13413 813000015 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906 813000016 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 813000017 putative acyl-acceptor binding pocket; other site 813000018 Uncharacterized conserved protein [Function unknown]; Region: COG1624 813000019 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 813000020 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 813000021 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 813000022 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 813000023 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 813000024 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 813000025 putative active site [active] 813000026 PhoH-like protein; Region: PhoH; pfam02562 813000027 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 813000028 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 813000029 HIGH motif; other site 813000030 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 813000031 active site 813000032 KMSKS motif; other site 813000033 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 813000034 tRNA binding surface [nucleotide binding]; other site 813000035 anticodon binding site; other site 813000036 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 813000037 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 813000038 Catalytic site [active] 813000039 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 813000040 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 813000041 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 813000042 peptide chain release factor 1; Validated; Region: prfA; PRK00591 813000043 PCRF domain; Region: PCRF; pfam03462 813000044 RF-1 domain; Region: RF-1; pfam00472 813000045 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 813000046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813000047 S-adenosylmethionine binding site [chemical binding]; other site 813000048 signal recognition particle protein; Provisional; Region: PRK10867 813000049 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 813000050 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 813000051 P loop; other site 813000052 GTP binding site [chemical binding]; other site 813000053 Signal peptide binding domain; Region: SRP_SPB; pfam02978 813000054 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 813000055 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 813000056 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 813000057 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 813000058 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 813000059 RNA/DNA hybrid binding site [nucleotide binding]; other site 813000060 active site 813000061 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 813000062 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 813000063 catalytic site [active] 813000064 G-X2-G-X-G-K; other site 813000065 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 813000066 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 813000067 active site 813000068 HIGH motif; other site 813000069 KMSKS motif; other site 813000070 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 813000071 tRNA binding surface [nucleotide binding]; other site 813000072 anticodon binding site; other site 813000073 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 813000074 AAA domain; Region: AAA_30; pfam13604 813000075 Family description; Region: UvrD_C_2; pfam13538 813000076 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 813000077 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 813000078 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 813000079 conserved cys residue [active] 813000080 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 813000081 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 813000082 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 813000083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813000084 Walker A motif; other site 813000085 ATP binding site [chemical binding]; other site 813000086 Walker B motif; other site 813000087 arginine finger; other site 813000088 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 813000089 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813000090 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 813000091 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 813000092 dimer interface [polypeptide binding]; other site 813000093 ssDNA binding site [nucleotide binding]; other site 813000094 tetramer (dimer of dimers) interface [polypeptide binding]; other site 813000095 multifunctional aminopeptidase A; Provisional; Region: PRK00913 813000096 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 813000097 interface (dimer of trimers) [polypeptide binding]; other site 813000098 Substrate-binding/catalytic site; other site 813000099 Zn-binding sites [ion binding]; other site 813000100 hypothetical protein; Provisional; Region: PRK05907 813000101 Predicted methyltransferases [General function prediction only]; Region: COG0313 813000102 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 813000103 putative SAM binding site [chemical binding]; other site 813000104 homodimer interface [polypeptide binding]; other site 813000105 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 813000106 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813000107 FeS/SAM binding site; other site 813000108 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 813000109 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 813000110 TPP-binding site [chemical binding]; other site 813000111 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 813000112 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 813000113 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813000114 E3 interaction surface; other site 813000115 lipoyl attachment site [posttranslational modification]; other site 813000116 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813000117 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 813000118 1-hydroxy-2-methyl-2-(e)-butenyl 4-diphosphate synthase [Lipid metabolism]; Region: gcpE; COG0821 813000119 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 813000120 ADP-ribose binding site [chemical binding]; other site 813000121 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 813000122 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 813000123 catalytic loop [active] 813000124 iron binding site [ion binding]; other site 813000125 type III secretion system protein; Validated; Region: PRK05910 813000126 FHIPEP family; Region: FHIPEP; pfam00771 813000127 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 813000128 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 813000129 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 813000130 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 813000131 DNA binding residues [nucleotide binding] 813000132 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 813000133 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 813000134 active site 813000135 HIGH motif; other site 813000136 dimer interface [polypeptide binding]; other site 813000137 KMSKS motif; other site 813000138 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813000139 RNA binding surface [nucleotide binding]; other site 813000140 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 813000141 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 813000142 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 813000143 GTP-binding protein LepA; Provisional; Region: PRK05433 813000144 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 813000145 G1 box; other site 813000146 putative GEF interaction site [polypeptide binding]; other site 813000147 GTP/Mg2+ binding site [chemical binding]; other site 813000148 Switch I region; other site 813000149 G2 box; other site 813000150 G3 box; other site 813000151 Switch II region; other site 813000152 G4 box; other site 813000153 G5 box; other site 813000154 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 813000155 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 813000156 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 813000157 ADP/ATP carrier protein family; Region: AAA; TIGR00769 813000158 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 813000159 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 813000160 intersubunit interface [polypeptide binding]; other site 813000161 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 813000162 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 813000163 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813000164 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813000165 ABC-ATPase subunit interface; other site 813000166 dimer interface [polypeptide binding]; other site 813000167 putative PBP binding regions; other site 813000168 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 813000169 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 813000170 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813000171 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813000172 ABC-ATPase subunit interface; other site 813000173 dimer interface [polypeptide binding]; other site 813000174 putative PBP binding regions; other site 813000175 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 813000176 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 813000177 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 813000178 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 813000179 RIP metalloprotease RseP; Region: TIGR00054 813000180 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 813000181 active site 813000182 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 813000183 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 813000184 putative substrate binding region [chemical binding]; other site 813000185 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 813000186 Putative serine esterase (DUF676); Region: DUF676; pfam05057 813000187 DNA polymerase III subunit beta; Validated; Region: PRK05643 813000188 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 813000189 putative DNA binding surface [nucleotide binding]; other site 813000190 dimer interface [polypeptide binding]; other site 813000191 beta-clamp/clamp loader binding surface; other site 813000192 beta-clamp/translesion DNA polymerase binding surface; other site 813000193 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 813000194 SmpB-tmRNA interface; other site 813000195 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 813000196 ApbE family; Region: ApbE; pfam02424 813000197 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 813000198 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 813000199 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 813000200 homodimer interface [polypeptide binding]; other site 813000201 NADP binding site [chemical binding]; other site 813000202 substrate binding site [chemical binding]; other site 813000203 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813000204 PLD-like domain; Region: PLDc_2; pfam13091 813000205 putative active site [active] 813000206 catalytic site [active] 813000207 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813000208 PLD-like domain; Region: PLDc_2; pfam13091 813000209 putative active site [active] 813000210 catalytic site [active] 813000211 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 813000212 4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446 813000213 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813000214 HrpJ-like domain; Region: HrpJ; cl15454 813000215 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 813000216 FHIPEP family; Region: FHIPEP; pfam00771 813000217 type III secretion system protein; Validated; Region: PRK06298 813000218 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 813000219 GTP-binding protein YchF; Reviewed; Region: PRK09601 813000220 YchF GTPase; Region: YchF; cd01900 813000221 G1 box; other site 813000222 GTP/Mg2+ binding site [chemical binding]; other site 813000223 Switch I region; other site 813000224 G2 box; other site 813000225 Switch II region; other site 813000226 G3 box; other site 813000227 G4 box; other site 813000228 G5 box; other site 813000229 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 813000230 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 813000231 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 813000232 active site 813000233 Riboflavin kinase; Region: Flavokinase; smart00904 813000234 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 813000235 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 813000236 RNA binding site [nucleotide binding]; other site 813000237 active site 813000238 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 813000239 transcription termination factor NusA; Region: NusA; TIGR01953 813000240 NusA N-terminal domain; Region: NusA_N; pfam08529 813000241 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 813000242 RNA binding site [nucleotide binding]; other site 813000243 homodimer interface [polypeptide binding]; other site 813000244 NusA-like KH domain; Region: KH_5; pfam13184 813000245 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 813000246 G-X-X-G motif; other site 813000247 ribosomal protein S1; Region: rpsA; TIGR00717 813000248 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 813000249 RNA binding site [nucleotide binding]; other site 813000250 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 813000251 RNA binding site [nucleotide binding]; other site 813000252 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813000253 RNA binding site [nucleotide binding]; other site 813000254 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813000255 RNA binding site [nucleotide binding]; other site 813000256 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 813000257 RNA binding site [nucleotide binding]; other site 813000258 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 813000259 RNA binding site [nucleotide binding]; other site 813000260 domain interface; other site 813000261 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 813000262 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 813000263 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 813000264 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 813000265 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 813000266 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 813000267 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 813000268 active site 813000269 motif I; other site 813000270 motif II; other site 813000271 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 813000272 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 813000273 NAD binding site [chemical binding]; other site 813000274 homotetramer interface [polypeptide binding]; other site 813000275 homodimer interface [polypeptide binding]; other site 813000276 substrate binding site [chemical binding]; other site 813000277 active site 813000278 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 813000279 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813000280 RNA binding surface [nucleotide binding]; other site 813000281 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 813000282 active site 813000283 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 813000284 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 813000285 minor groove reading motif; other site 813000286 helix-hairpin-helix signature motif; other site 813000287 substrate binding pocket [chemical binding]; other site 813000288 active site 813000289 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 813000290 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 813000291 DNA binding and oxoG recognition site [nucleotide binding] 813000292 Uncharacterized conserved protein [Function unknown]; Region: COG0327 813000293 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 813000294 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 813000295 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 813000296 ring oligomerisation interface [polypeptide binding]; other site 813000297 ATP/Mg binding site [chemical binding]; other site 813000298 stacking interactions; other site 813000299 hinge regions; other site 813000300 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 813000301 oligomerisation interface [polypeptide binding]; other site 813000302 mobile loop; other site 813000303 roof hairpin; other site 813000304 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 813000305 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 813000306 active site 813000307 Zn binding site [ion binding]; other site 813000308 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 813000309 Clp amino terminal domain; Region: Clp_N; pfam02861 813000310 Clp amino terminal domain; Region: Clp_N; pfam02861 813000311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813000312 Walker A motif; other site 813000313 ATP binding site [chemical binding]; other site 813000314 Walker B motif; other site 813000315 arginine finger; other site 813000316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813000317 Walker A motif; other site 813000318 ATP binding site [chemical binding]; other site 813000319 Walker B motif; other site 813000320 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 813000321 Uncharacterized conserved protein [Function unknown]; Region: COG2912 813000322 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 813000323 IncA protein; Region: IncA; pfam04156 813000324 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 813000325 elongation factor P; Provisional; Region: PRK12426 813000326 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813000327 RNA binding site [nucleotide binding]; other site 813000328 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 813000329 RNA binding site [nucleotide binding]; other site 813000330 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 813000331 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 813000332 carboxyltransferase (CT) interaction site; other site 813000333 biotinylation site [posttranslational modification]; other site 813000334 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 813000335 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 813000336 ATP-grasp domain; Region: ATP-grasp_4; cl17255 813000337 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 813000338 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 813000339 23S rRNA interface [nucleotide binding]; other site 813000340 L3 interface [polypeptide binding]; other site 813000341 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 813000342 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 813000343 NlpC/P60 family; Region: NLPC_P60; cl17555 813000344 adenylate kinase; Reviewed; Region: adk; PRK00279 813000345 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 813000346 AMP-binding site [chemical binding]; other site 813000347 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 813000348 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 813000349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813000350 dimer interface [polypeptide binding]; other site 813000351 conserved gate region; other site 813000352 putative PBP binding loops; other site 813000353 ABC-ATPase subunit interface; other site 813000354 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 813000355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813000356 Walker A/P-loop; other site 813000357 ATP binding site [chemical binding]; other site 813000358 Q-loop/lid; other site 813000359 ABC transporter signature motif; other site 813000360 Walker B; other site 813000361 D-loop; other site 813000362 H-loop/switch region; other site 813000363 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 813000364 Methyltransferase domain; Region: Methyltransf_23; pfam13489 813000365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813000366 S-adenosylmethionine binding site [chemical binding]; other site 813000367 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 813000368 Serine hydrolase (FSH1); Region: FSH1; pfam03959 813000369 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 813000370 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 813000371 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 813000372 active site 813000373 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 813000374 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 813000375 conserved hypothetical integral membrane protein; Region: TIGR00697 813000376 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 813000377 SEC-C motif; Region: SEC-C; pfam02810 813000378 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 813000379 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813000380 active site 813000381 ATP binding site [chemical binding]; other site 813000382 substrate binding site [chemical binding]; other site 813000383 activation loop (A-loop); other site 813000384 Uncharacterized conserved protein [Function unknown]; Region: COG1262 813000385 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 813000386 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 813000387 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 813000388 nucleotide binding pocket [chemical binding]; other site 813000389 K-X-D-G motif; other site 813000390 catalytic site [active] 813000391 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 813000392 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 813000393 Helix-hairpin-helix motif; Region: HHH; pfam00633 813000394 helix-hairpin-helix signature motif; other site 813000395 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 813000396 Dimer interface [polypeptide binding]; other site 813000397 BRCT sequence motif; other site 813000398 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 813000399 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 813000400 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 813000401 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 813000402 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 813000403 FtsX-like permease family; Region: FtsX; pfam02687 813000404 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 813000405 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 813000406 Walker A/P-loop; other site 813000407 ATP binding site [chemical binding]; other site 813000408 Q-loop/lid; other site 813000409 ABC transporter signature motif; other site 813000410 Walker B; other site 813000411 D-loop; other site 813000412 H-loop/switch region; other site 813000413 membrane-attack complex / perforin; Region: MACPF; smart00457 813000414 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 813000415 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813000416 PLD-like domain; Region: PLDc_2; pfam13091 813000417 putative active site [active] 813000418 catalytic site [active] 813000419 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813000420 PLD-like domain; Region: PLDc_2; pfam13091 813000421 putative active site [active] 813000422 catalytic site [active] 813000423 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813000424 PLD-like domain; Region: PLDc_2; pfam13091 813000425 putative active site [active] 813000426 catalytic site [active] 813000427 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813000428 PLD-like domain; Region: PLDc_2; pfam13091 813000429 putative active site [active] 813000430 catalytic site [active] 813000431 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813000432 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 813000433 trp operon repressor, proteobacterial; Region: TrpR; TIGR01321 813000434 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 813000435 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 813000436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813000437 catalytic residue [active] 813000438 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 813000439 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 813000440 substrate binding site [chemical binding]; other site 813000441 active site 813000442 catalytic residues [active] 813000443 heterodimer interface [polypeptide binding]; other site 813000444 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 813000445 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 813000446 peptide binding site [polypeptide binding]; other site 813000447 putative disulfide oxidoreductase; Provisional; Region: PRK00611 813000448 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 813000449 putative active site [active] 813000450 redox center [active] 813000451 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 813000452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813000453 Walker A/P-loop; other site 813000454 ATP binding site [chemical binding]; other site 813000455 Q-loop/lid; other site 813000456 ABC transporter signature motif; other site 813000457 Walker B; other site 813000458 D-loop; other site 813000459 H-loop/switch region; other site 813000460 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 813000461 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 813000462 Ligand binding site; other site 813000463 oligomer interface; other site 813000464 CTP synthetase; Validated; Region: pyrG; PRK05380 813000465 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 813000466 Catalytic site [active] 813000467 active site 813000468 UTP binding site [chemical binding]; other site 813000469 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 813000470 active site 813000471 putative oxyanion hole; other site 813000472 catalytic triad [active] 813000473 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 813000474 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 813000475 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 813000476 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 813000477 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 813000478 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 813000479 putative active site [active] 813000480 DNA polymerase III subunit delta'; Validated; Region: PRK05917 813000481 DNA polymerase III subunit delta'; Validated; Region: PRK08485 813000482 thymidylate kinase; Validated; Region: tmk; PRK00698 813000483 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 813000484 TMP-binding site; other site 813000485 ATP-binding site [chemical binding]; other site 813000486 DNA gyrase, A subunit; Region: gyrA; TIGR01063 813000487 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 813000488 CAP-like domain; other site 813000489 active site 813000490 primary dimer interface [polypeptide binding]; other site 813000491 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813000492 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813000493 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813000494 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813000495 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813000496 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813000497 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 813000498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813000499 ATP binding site [chemical binding]; other site 813000500 Mg2+ binding site [ion binding]; other site 813000501 G-X-G motif; other site 813000502 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 813000503 anchoring element; other site 813000504 dimer interface [polypeptide binding]; other site 813000505 ATP binding site [chemical binding]; other site 813000506 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 813000507 active site 813000508 putative metal-binding site [ion binding]; other site 813000509 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 813000510 Protein of unknown function (DUF721); Region: DUF721; pfam05258 813000511 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 813000512 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 813000513 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 813000514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813000515 dimer interface [polypeptide binding]; other site 813000516 conserved gate region; other site 813000517 putative PBP binding loops; other site 813000518 ABC-ATPase subunit interface; other site 813000519 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 813000520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813000521 dimer interface [polypeptide binding]; other site 813000522 conserved gate region; other site 813000523 putative PBP binding loops; other site 813000524 ABC-ATPase subunit interface; other site 813000525 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813000526 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 813000527 Walker A/P-loop; other site 813000528 ATP binding site [chemical binding]; other site 813000529 Q-loop/lid; other site 813000530 ABC transporter signature motif; other site 813000531 Walker B; other site 813000532 D-loop; other site 813000533 H-loop/switch region; other site 813000534 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 813000535 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 813000536 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813000537 Walker A/P-loop; other site 813000538 ATP binding site [chemical binding]; other site 813000539 Q-loop/lid; other site 813000540 ABC transporter signature motif; other site 813000541 Walker B; other site 813000542 D-loop; other site 813000543 H-loop/switch region; other site 813000544 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813000545 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 813000546 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 813000547 transmembrane helices; other site 813000548 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 813000549 active site 813000550 ADP/pyrophosphate binding site [chemical binding]; other site 813000551 dimerization interface [polypeptide binding]; other site 813000552 allosteric effector site; other site 813000553 fructose-1,6-bisphosphate binding site; other site 813000554 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 813000555 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 813000556 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 813000557 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 813000558 active site 813000559 ADP/pyrophosphate binding site [chemical binding]; other site 813000560 dimerization interface [polypeptide binding]; other site 813000561 allosteric effector site; other site 813000562 fructose-1,6-bisphosphate binding site; other site 813000563 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 813000564 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 813000565 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 813000566 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 813000567 HIGH motif; other site 813000568 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 813000569 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 813000570 active site 813000571 KMSKS motif; other site 813000572 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 813000573 tRNA binding surface [nucleotide binding]; other site 813000574 Putative transcriptional regulator [Transcription]; Region: COG1678 813000575 Uncharacterized conserved protein [Function unknown]; Region: COG1259 813000576 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 813000577 tetramer (dimer of dimers) interface [polypeptide binding]; other site 813000578 active site 813000579 dimer interface [polypeptide binding]; other site 813000580 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 813000581 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 813000582 putative active site; other site 813000583 catalytic residue [active] 813000584 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 813000585 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 813000586 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 813000587 Ligand Binding Site [chemical binding]; other site 813000588 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 813000589 prenyltransferase; Reviewed; Region: ubiA; PRK12876 813000590 UbiA prenyltransferase family; Region: UbiA; pfam01040 813000591 aromatic acid decarboxylase; Validated; Region: PRK05920 813000592 Flavoprotein; Region: Flavoprotein; pfam02441 813000593 Uncharacterized conserved protein [Function unknown]; Region: COG1284 813000594 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 813000595 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813000596 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 813000597 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 813000598 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 813000599 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 813000600 Na2 binding site [ion binding]; other site 813000601 putative substrate binding site 1 [chemical binding]; other site 813000602 Na binding site 1 [ion binding]; other site 813000603 putative substrate binding site 2 [chemical binding]; other site 813000604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813000605 putative substrate translocation pore; other site 813000606 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 813000607 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 813000608 ligand binding site [chemical binding]; other site 813000609 flexible hinge region; other site 813000610 acyl carrier protein; Provisional; Region: acpP; PRK00982 813000611 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 813000612 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 813000613 NAD(P) binding site [chemical binding]; other site 813000614 homotetramer interface [polypeptide binding]; other site 813000615 homodimer interface [polypeptide binding]; other site 813000616 active site 813000617 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 813000618 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 813000619 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 813000620 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 813000621 dimer interface [polypeptide binding]; other site 813000622 active site 813000623 CoA binding pocket [chemical binding]; other site 813000624 recombination protein RecR; Region: recR; TIGR00615 813000625 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 813000626 putative active site [active] 813000627 putative metal-binding site [ion binding]; other site 813000628 tetramer interface [polypeptide binding]; other site 813000629 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 813000630 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813000631 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813000632 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813000633 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813000634 Surface antigen; Region: Bac_surface_Ag; pfam01103 813000635 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 813000636 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 813000637 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 813000638 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 813000639 trimer interface [polypeptide binding]; other site 813000640 active site 813000641 UDP-GlcNAc binding site [chemical binding]; other site 813000642 lipid binding site [chemical binding]; lipid-binding site 813000643 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 813000644 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 813000645 tetramer interface [polypeptide binding]; other site 813000646 TPP-binding site [chemical binding]; other site 813000647 heterodimer interface [polypeptide binding]; other site 813000648 phosphorylation loop region [posttranslational modification] 813000649 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 813000650 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 813000651 alpha subunit interface [polypeptide binding]; other site 813000652 TPP binding site [chemical binding]; other site 813000653 heterodimer interface [polypeptide binding]; other site 813000654 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813000655 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 813000656 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813000657 E3 interaction surface; other site 813000658 lipoyl attachment site [posttranslational modification]; other site 813000659 e3 binding domain; Region: E3_binding; pfam02817 813000660 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813000661 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 813000662 homodimer interface [polypeptide binding]; other site 813000663 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 813000664 active site pocket [active] 813000665 chromosomal replication initiation protein; Provisional; Region: PRK12422 813000666 DnaA N-terminal domain; Region: DnaA_N; pfam11638 813000667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813000668 Walker A motif; other site 813000669 ATP binding site [chemical binding]; other site 813000670 Walker B motif; other site 813000671 arginine finger; other site 813000672 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 813000673 DnaA box-binding interface [nucleotide binding]; other site 813000674 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 813000675 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 813000676 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 813000677 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 813000678 homodimer interface [polypeptide binding]; other site 813000679 metal binding site [ion binding]; metal-binding site 813000680 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 813000681 Domain of unknown function DUF21; Region: DUF21; pfam01595 813000682 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813000683 Transporter associated domain; Region: CorC_HlyC; smart01091 813000684 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 813000685 Domain of unknown function DUF21; Region: DUF21; pfam01595 813000686 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813000687 Transporter associated domain; Region: CorC_HlyC; smart01091 813000688 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 813000689 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 813000690 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813000691 catalytic residue [active] 813000692 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 813000693 Protein phosphatase 2C; Region: PP2C; pfam00481 813000694 active site 813000695 Uncharacterized conserved protein [Function unknown]; Region: COG5465 813000696 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 813000697 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 813000698 active site 813000699 catalytic site [active] 813000700 substrate binding site [chemical binding]; other site 813000701 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 813000702 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 813000703 nucleosidase; Provisional; Region: PRK05634 813000704 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 813000705 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 813000706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813000707 Walker A/P-loop; other site 813000708 ATP binding site [chemical binding]; other site 813000709 Q-loop/lid; other site 813000710 ABC transporter signature motif; other site 813000711 Walker B; other site 813000712 D-loop; other site 813000713 H-loop/switch region; other site 813000714 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 813000715 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 813000716 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 813000717 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 813000718 active site 813000719 metal binding site [ion binding]; metal-binding site 813000720 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 813000721 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 813000722 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813000723 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813000724 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 813000725 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 813000726 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 813000727 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 813000728 MraW methylase family; Region: Methyltransf_5; pfam01795 813000729 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813000730 TPR motif; other site 813000731 binding surface 813000732 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 813000733 DnaA N-terminal domain; Region: DnaA_N; pfam11638 813000734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813000735 Walker A motif; other site 813000736 ATP binding site [chemical binding]; other site 813000737 Walker B motif; other site 813000738 arginine finger; other site 813000739 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 813000740 DnaA box-binding interface [nucleotide binding]; other site 813000741 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 813000742 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 813000743 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 813000744 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 813000745 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 813000746 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 813000747 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 813000748 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 813000749 lipoyl attachment site [posttranslational modification]; other site 813000750 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 813000751 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 813000752 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813000753 putative active site [active] 813000754 catalytic site [active] 813000755 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813000756 putative active site [active] 813000757 catalytic site [active] 813000758 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 813000759 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 813000760 Clp amino terminal domain; Region: Clp_N; pfam02861 813000761 Clp amino terminal domain; Region: Clp_N; pfam02861 813000762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813000763 Walker A motif; other site 813000764 ATP binding site [chemical binding]; other site 813000765 Walker B motif; other site 813000766 arginine finger; other site 813000767 UvrB/uvrC motif; Region: UVR; pfam02151 813000768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813000769 Walker A motif; other site 813000770 ATP binding site [chemical binding]; other site 813000771 Walker B motif; other site 813000772 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 813000773 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 813000774 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 813000775 Ligand Binding Site [chemical binding]; other site 813000776 Helix-turn-helix domain; Region: HTH_17; pfam12728 813000777 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 813000778 active site 813000779 phosphorylation site [posttranslational modification] 813000780 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 813000781 active site 813000782 phosphorylation site [posttranslational modification] 813000783 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 813000784 trimer interface [polypeptide binding]; other site 813000785 active site 813000786 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 813000787 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 813000788 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 813000789 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 813000790 active site 813000791 substrate binding site [chemical binding]; other site 813000792 metal binding site [ion binding]; metal-binding site 813000793 ribonuclease III; Reviewed; Region: rnc; PRK00102 813000794 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 813000795 dimerization interface [polypeptide binding]; other site 813000796 active site 813000797 metal binding site [ion binding]; metal-binding site 813000798 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 813000799 dsRNA binding site [nucleotide binding]; other site 813000800 DNA repair protein RadA; Provisional; Region: PRK11823 813000801 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 813000802 Walker A motif/ATP binding site; other site 813000803 ATP binding site [chemical binding]; other site 813000804 Walker B motif; other site 813000805 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 813000806 porphobilinogen deaminase; Provisional; Region: PRK01066 813000807 Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379 813000808 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 813000809 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813000810 active site 813000811 ATP binding site [chemical binding]; other site 813000812 substrate binding site [chemical binding]; other site 813000813 activation loop (A-loop); other site 813000814 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 813000815 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 813000816 HIGH motif; other site 813000817 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 813000818 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 813000819 active site 813000820 KMSKS motif; other site 813000821 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 813000822 tRNA binding surface [nucleotide binding]; other site 813000823 anticodon binding site; other site 813000824 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 813000825 V-type ATP synthase subunit K; Provisional; Region: PRK09621 813000826 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 813000827 V-type ATP synthase subunit I; Validated; Region: PRK05771 813000828 Protein of unknown function (DUF1319); Region: DUF1319; pfam07028 813000829 V-type ATP synthase subunit D; Provisional; Region: PRK02195 813000830 V-type ATP synthase subunit B; Provisional; Region: PRK02118 813000831 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813000832 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 813000833 Walker A motif homologous position; other site 813000834 Walker B motif; other site 813000835 V-type ATP synthase subunit A; Provisional; Region: PRK04192 813000836 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813000837 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 813000838 Walker A motif/ATP binding site; other site 813000839 Walker B motif; other site 813000840 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 813000841 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 813000842 V-type ATP synthase subunit E; Provisional; Region: PRK01005 813000843 V-type ATP synthase subunit E; Provisional; Region: PRK01558 813000844 transaldolase-like protein; Provisional; Region: PTZ00411 813000845 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 813000846 active site 813000847 dimer interface [polypeptide binding]; other site 813000848 catalytic residue [active] 813000849 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 813000850 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 813000851 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 813000852 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 813000853 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 813000854 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 813000855 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 813000856 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 813000857 DNA binding site [nucleotide binding] 813000858 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 813000859 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 813000860 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 813000861 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 813000862 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 813000863 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 813000864 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 813000865 RPB12 interaction site [polypeptide binding]; other site 813000866 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 813000867 RPB3 interaction site [polypeptide binding]; other site 813000868 RPB1 interaction site [polypeptide binding]; other site 813000869 RPB11 interaction site [polypeptide binding]; other site 813000870 RPB10 interaction site [polypeptide binding]; other site 813000871 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 813000872 L11 interface [polypeptide binding]; other site 813000873 putative EF-Tu interaction site [polypeptide binding]; other site 813000874 putative EF-G interaction site [polypeptide binding]; other site 813000875 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 813000876 23S rRNA interface [nucleotide binding]; other site 813000877 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 813000878 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 813000879 mRNA/rRNA interface [nucleotide binding]; other site 813000880 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 813000881 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 813000882 putative thiostrepton binding site; other site 813000883 23S rRNA interface [nucleotide binding]; other site 813000884 L7/L12 interface [polypeptide binding]; other site 813000885 L25 interface [polypeptide binding]; other site 813000886 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 813000887 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 813000888 putative homodimer interface [polypeptide binding]; other site 813000889 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 813000890 heterodimer interface [polypeptide binding]; other site 813000891 homodimer interface [polypeptide binding]; other site 813000892 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 813000893 elongation factor Tu; Reviewed; Region: PRK12735 813000894 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 813000895 G1 box; other site 813000896 GEF interaction site [polypeptide binding]; other site 813000897 GTP/Mg2+ binding site [chemical binding]; other site 813000898 Switch I region; other site 813000899 G2 box; other site 813000900 G3 box; other site 813000901 Switch II region; other site 813000902 G4 box; other site 813000903 G5 box; other site 813000904 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 813000905 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 813000906 Antibiotic Binding Site [chemical binding]; other site 813000907 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 813000908 rRNA binding site [nucleotide binding]; other site 813000909 predicted 30S ribosome binding site; other site 813000910 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 813000911 Protein of unknown function (DUF687); Region: DUF687; pfam05095 813000912 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 813000913 active site 813000914 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 813000915 triosephosphate isomerase; Provisional; Region: PRK14565 813000916 substrate binding site [chemical binding]; other site 813000917 dimer interface [polypeptide binding]; other site 813000918 catalytic triad [active] 813000919 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 813000920 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 813000921 generic binding surface II; other site 813000922 generic binding surface I; other site 813000923 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 813000924 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 813000925 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 813000926 TPP-binding site [chemical binding]; other site 813000927 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 813000928 PYR/PP interface [polypeptide binding]; other site 813000929 dimer interface [polypeptide binding]; other site 813000930 TPP binding site [chemical binding]; other site 813000931 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813000932 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 813000933 pyruvate kinase; Region: pyruv_kin; TIGR01064 813000934 domain interfaces; other site 813000935 active site 813000936 excinuclease ABC subunit A; Provisional; Region: PRK00635 813000937 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 813000938 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 813000939 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 813000940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813000941 Walker A/P-loop; other site 813000942 ATP binding site [chemical binding]; other site 813000943 Q-loop/lid; other site 813000944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813000945 ABC transporter signature motif; other site 813000946 Walker B; other site 813000947 D-loop; other site 813000948 H-loop/switch region; other site 813000949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813000950 Walker A/P-loop; other site 813000951 ATP binding site [chemical binding]; other site 813000952 Q-loop/lid; other site 813000953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813000954 Q-loop/lid; other site 813000955 ABC transporter signature motif; other site 813000956 Walker B; other site 813000957 D-loop; other site 813000958 H-loop/switch region; other site 813000959 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 813000960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813000961 Walker A motif; other site 813000962 ATP binding site [chemical binding]; other site 813000963 Walker B motif; other site 813000964 arginine finger; other site 813000965 hypothetical protein; Validated; Region: PRK00153 813000966 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 813000967 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 813000968 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 813000969 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 813000970 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 813000971 Competence protein; Region: Competence; pfam03772 813000972 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 813000973 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 813000974 tetramer interface [polypeptide binding]; other site 813000975 TPP-binding site [chemical binding]; other site 813000976 heterodimer interface [polypeptide binding]; other site 813000977 phosphorylation loop region [posttranslational modification] 813000978 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 813000979 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 813000980 alpha subunit interface [polypeptide binding]; other site 813000981 TPP binding site [chemical binding]; other site 813000982 heterodimer interface [polypeptide binding]; other site 813000983 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813000984 chaperone protein DnaJ; Provisional; Region: PRK14284 813000985 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 813000986 HSP70 interaction site [polypeptide binding]; other site 813000987 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 813000988 Zn binding sites [ion binding]; other site 813000989 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 813000990 dimer interface [polypeptide binding]; other site 813000991 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 813000992 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 813000993 Glycoprotease family; Region: Peptidase_M22; pfam00814 813000994 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 813000995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813000996 Walker A motif; other site 813000997 ATP binding site [chemical binding]; other site 813000998 Walker B motif; other site 813000999 arginine finger; other site 813001000 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 813001001 ribonuclease Z; Region: RNase_Z; TIGR02651 813001002 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 813001003 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 813001004 active site 813001005 Int/Topo IB signature motif; other site 813001006 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 813001007 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813001008 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813001009 ABC transporter; Region: ABC_tran_2; pfam12848 813001010 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813001011 Maf-like protein; Region: Maf; pfam02545 813001012 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 813001013 active site 813001014 dimer interface [polypeptide binding]; other site 813001015 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 813001016 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 813001017 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 813001018 active site 813001019 catalytic residues [active] 813001020 metal binding site [ion binding]; metal-binding site 813001021 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 813001022 dimethyladenosine transferase; Region: ksgA; TIGR00755 813001023 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 813001024 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 813001025 catalytic residues [active] 813001026 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 813001027 dihydrodipicolinate synthase; Region: dapA; TIGR00674 813001028 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 813001029 inhibitor site; inhibition site 813001030 active site 813001031 dimer interface [polypeptide binding]; other site 813001032 catalytic residue [active] 813001033 aspartate kinase; Provisional; Region: PRK05925 813001034 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 813001035 putative catalytic residues [active] 813001036 nucleotide binding site [chemical binding]; other site 813001037 aspartate binding site [chemical binding]; other site 813001038 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 813001039 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 813001040 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 813001041 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 813001042 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 813001043 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 813001044 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 813001045 hinge; other site 813001046 active site 813001047 shikimate kinase; Provisional; Region: PRK00625 813001048 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 813001049 ADP binding site [chemical binding]; other site 813001050 magnesium binding site [ion binding]; other site 813001051 putative shikimate binding site; other site 813001052 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 813001053 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 813001054 Tetramer interface [polypeptide binding]; other site 813001055 active site 813001056 FMN-binding site [chemical binding]; other site 813001057 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 813001058 active site 813001059 dimer interface [polypeptide binding]; other site 813001060 metal binding site [ion binding]; metal-binding site 813001061 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 813001062 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 813001063 active site 813001064 catalytic residue [active] 813001065 dimer interface [polypeptide binding]; other site 813001066 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 813001067 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 813001068 shikimate binding site; other site 813001069 NAD(P) binding site [chemical binding]; other site 813001070 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 813001071 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 813001072 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 813001073 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 813001074 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 813001075 malate dehydrogenase; Provisional; Region: PRK05442 813001076 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 813001077 NAD(P) binding site [chemical binding]; other site 813001078 dimer interface [polypeptide binding]; other site 813001079 malate binding site [chemical binding]; other site 813001080 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 813001081 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 813001082 active site 813001083 dimer interface [polypeptide binding]; other site 813001084 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 813001085 dimer interface [polypeptide binding]; other site 813001086 active site 813001087 GTPases [General function prediction only]; Region: HflX; COG2262 813001088 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 813001089 HflX GTPase family; Region: HflX; cd01878 813001090 G1 box; other site 813001091 GTP/Mg2+ binding site [chemical binding]; other site 813001092 Switch I region; other site 813001093 G2 box; other site 813001094 G3 box; other site 813001095 Switch II region; other site 813001096 G4 box; other site 813001097 G5 box; other site 813001098 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 813001099 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 813001100 substrate binding pocket [chemical binding]; other site 813001101 membrane-bound complex binding site; other site 813001102 hinge residues; other site 813001103 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 813001104 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 813001105 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 813001106 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 813001107 nucleotide binding site/active site [active] 813001108 Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286 813001109 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 813001110 hypothetical protein; Validated; Region: PRK00647 813001111 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 813001112 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 813001113 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 813001114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813001115 homodimer interface [polypeptide binding]; other site 813001116 catalytic residue [active] 813001117 ABC transporter substrate binding protein; Region: ABC_sub_bind; pfam04392 813001118 prolyl-tRNA synthetase; Provisional; Region: PRK09194 813001119 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 813001120 dimer interface [polypeptide binding]; other site 813001121 motif 1; other site 813001122 active site 813001123 motif 2; other site 813001124 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 813001125 putative deacylase active site [active] 813001126 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813001127 active site 813001128 motif 3; other site 813001129 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 813001130 anticodon binding site; other site 813001131 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 813001132 GrpE; Region: GrpE; pfam01025 813001133 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 813001134 dimer interface [polypeptide binding]; other site 813001135 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 813001136 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 813001137 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 813001138 nucleotide binding site [chemical binding]; other site 813001139 NEF interaction site [polypeptide binding]; other site 813001140 SBD interface [polypeptide binding]; other site 813001141 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 813001142 Exoribonuclease R [Transcription]; Region: VacB; COG0557 813001143 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 813001144 RNB domain; Region: RNB; pfam00773 813001145 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 813001146 Putative zinc ribbon domain; Region: DUF164; pfam02591 813001147 KpsF/GutQ family protein; Region: kpsF; TIGR00393 813001148 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 813001149 putative active site [active] 813001150 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 813001151 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 813001152 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813001153 E3 interaction surface; other site 813001154 lipoyl attachment site [posttranslational modification]; other site 813001155 e3 binding domain; Region: E3_binding; pfam02817 813001156 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813001157 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 813001158 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 813001159 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 813001160 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 813001161 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 813001162 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 813001163 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 813001164 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 813001165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813001166 S-adenosylmethionine binding site [chemical binding]; other site 813001167 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 813001168 Lumazine binding domain; Region: Lum_binding; pfam00677 813001169 Lumazine binding domain; Region: Lum_binding; pfam00677 813001170 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 813001171 ATP cone domain; Region: ATP-cone; pfam03477 813001172 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 813001173 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 813001174 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 813001175 amino acid carrier protein; Region: agcS; TIGR00835 813001176 poly(A) polymerase; Region: pcnB; TIGR01942 813001177 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 813001178 active site 813001179 NTP binding site [chemical binding]; other site 813001180 metal binding triad [ion binding]; metal-binding site 813001181 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 813001182 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 813001183 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 813001184 Predicted membrane protein [Function unknown]; Region: COG3952 813001185 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 813001186 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813001187 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813001188 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813001189 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813001190 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813001191 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813001192 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813001193 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813001194 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 813001195 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 813001196 intersubunit interface [polypeptide binding]; other site 813001197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813001198 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 813001199 Walker A/P-loop; other site 813001200 ATP binding site [chemical binding]; other site 813001201 Q-loop/lid; other site 813001202 ABC transporter signature motif; other site 813001203 Walker B; other site 813001204 D-loop; other site 813001205 H-loop/switch region; other site 813001206 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813001207 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813001208 ABC-ATPase subunit interface; other site 813001209 dimer interface [polypeptide binding]; other site 813001210 putative PBP binding regions; other site 813001211 GTPase CgtA; Reviewed; Region: obgE; PRK12299 813001212 GTP1/OBG; Region: GTP1_OBG; pfam01018 813001213 Obg GTPase; Region: Obg; cd01898 813001214 G1 box; other site 813001215 GTP/Mg2+ binding site [chemical binding]; other site 813001216 Switch I region; other site 813001217 G2 box; other site 813001218 G3 box; other site 813001219 Switch II region; other site 813001220 G4 box; other site 813001221 G5 box; other site 813001222 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 813001223 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 813001224 Uncharacterized conserved protein [Function unknown]; Region: COG2928 813001225 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 813001226 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 813001227 FOG: CBS domain [General function prediction only]; Region: COG0517 813001228 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813001229 Transporter associated domain; Region: CorC_HlyC; smart01091 813001230 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 813001231 anti sigma factor interaction site; other site 813001232 regulatory phosphorylation site [posttranslational modification]; other site 813001233 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 813001234 hypothetical protein; Provisional; Region: PRK05926 813001235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813001236 FeS/SAM binding site; other site 813001237 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 813001238 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 813001239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813001240 S-adenosylmethionine binding site [chemical binding]; other site 813001241 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 813001242 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 813001243 diaminopimelate epimerase; Region: DapF; TIGR00652 813001244 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 813001245 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 813001246 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 813001247 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 813001248 oligomer interface [polypeptide binding]; other site 813001249 active site residues [active] 813001250 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 813001251 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 813001252 active site 813001253 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 813001254 homotrimer interaction site [polypeptide binding]; other site 813001255 zinc binding site [ion binding]; other site 813001256 CDP-binding sites; other site 813001257 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 813001258 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 813001259 FAD binding pocket [chemical binding]; other site 813001260 conserved FAD binding motif [chemical binding]; other site 813001261 phosphate binding motif [ion binding]; other site 813001262 beta-alpha-beta structure motif; other site 813001263 NAD binding pocket [chemical binding]; other site 813001264 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 813001265 elongation factor G; Reviewed; Region: PRK12739 813001266 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 813001267 G1 box; other site 813001268 putative GEF interaction site [polypeptide binding]; other site 813001269 GTP/Mg2+ binding site [chemical binding]; other site 813001270 Switch I region; other site 813001271 G2 box; other site 813001272 G3 box; other site 813001273 Switch II region; other site 813001274 G4 box; other site 813001275 G5 box; other site 813001276 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 813001277 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 813001278 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 813001279 30S ribosomal protein S7; Validated; Region: PRK05302 813001280 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 813001281 S17 interaction site [polypeptide binding]; other site 813001282 S8 interaction site; other site 813001283 16S rRNA interaction site [nucleotide binding]; other site 813001284 streptomycin interaction site [chemical binding]; other site 813001285 23S rRNA interaction site [nucleotide binding]; other site 813001286 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 813001287 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 813001288 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 813001289 protein binding site [polypeptide binding]; other site 813001290 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 813001291 Catalytic dyad [active] 813001292 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 813001293 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 813001294 Domain of unknown function DUF11; Region: DUF11; pfam01345 813001295 Domain of unknown function DUF11; Region: DUF11; pfam01345 813001296 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 813001297 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 813001298 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 813001299 HIGH motif; other site 813001300 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 813001301 active site 813001302 KMSKS motif; other site 813001303 Helix-turn-helix domain; Region: HTH_17; pfam12728 813001304 Helix-turn-helix domain; Region: HTH_17; pfam12728 813001305 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 813001306 DHH family; Region: DHH; pfam01368 813001307 DHHA1 domain; Region: DHHA1; pfam02272 813001308 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 813001309 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 813001310 Protein export membrane protein; Region: SecD_SecF; pfam02355 813001311 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 813001312 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 813001313 catalytic residue [active] 813001314 putative FPP diphosphate binding site; other site 813001315 putative FPP binding hydrophobic cleft; other site 813001316 dimer interface [polypeptide binding]; other site 813001317 putative IPP diphosphate binding site; other site 813001318 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 813001319 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 813001320 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 813001321 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 813001322 CMP-binding site; other site 813001323 The sites determining sugar specificity; other site 813001324 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 813001325 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 813001326 putative acyl-acceptor binding pocket; other site 813001327 arginine-tRNA ligase; Region: PLN02286 813001328 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 813001329 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 813001330 active site 813001331 HIGH motif; other site 813001332 KMSK motif region; other site 813001333 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813001334 tRNA binding surface [nucleotide binding]; other site 813001335 anticodon binding site; other site 813001336 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 813001337 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 813001338 hinge; other site 813001339 active site 813001340 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 813001341 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 813001342 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 813001343 Coenzyme A binding pocket [chemical binding]; other site 813001344 PCRF domain; Region: PCRF; pfam03462 813001345 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 813001346 RF-1 domain; Region: RF-1; pfam00472 813001347 SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531 813001348 SWI complex, BAF60b domains; Region: SWIB; smart00151 813001349 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 813001350 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813001351 putative active site [active] 813001352 putative metal binding site [ion binding]; other site 813001353 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 813001354 substrate binding site; other site 813001355 dimer interface; other site 813001356 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 813001357 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 813001358 dimerization interface 3.5A [polypeptide binding]; other site 813001359 active site 813001360 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 813001361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 813001362 active site 813001363 motif I; other site 813001364 motif II; other site 813001365 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 813001366 PAS domain; Region: PAS; smart00091 813001367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 813001368 dimer interface [polypeptide binding]; other site 813001369 phosphorylation site [posttranslational modification] 813001370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813001371 ATP binding site [chemical binding]; other site 813001372 Mg2+ binding site [ion binding]; other site 813001373 G-X-G motif; other site 813001374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 813001375 Response regulator receiver domain; Region: Response_reg; pfam00072 813001376 active site 813001377 phosphorylation site [posttranslational modification] 813001378 intermolecular recognition site; other site 813001379 dimerization interface [polypeptide binding]; other site 813001380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813001381 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 813001382 Walker A motif; other site 813001383 ATP binding site [chemical binding]; other site 813001384 Walker B motif; other site 813001385 arginine finger; other site 813001386 Recombination protein O N terminal; Region: RecO_N; pfam11967 813001387 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 813001388 Recombination protein O C terminal; Region: RecO_C; pfam02565 813001389 Uncharacterized conserved protein [Function unknown]; Region: COG1723 813001390 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 813001391 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 813001392 putative tRNA-binding site [nucleotide binding]; other site 813001393 B3/4 domain; Region: B3_4; pfam03483 813001394 tRNA synthetase B5 domain; Region: B5; smart00874 813001395 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 813001396 dimer interface [polypeptide binding]; other site 813001397 motif 1; other site 813001398 motif 3; other site 813001399 motif 2; other site 813001400 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 813001401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813001402 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 813001403 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 813001404 DNA binding site [nucleotide binding] 813001405 active site 813001406 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 813001407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813001408 dimer interface [polypeptide binding]; other site 813001409 conserved gate region; other site 813001410 putative PBP binding loops; other site 813001411 ABC-ATPase subunit interface; other site 813001412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 813001413 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 813001414 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 813001415 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 813001416 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 813001417 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 813001418 putative active site [active] 813001419 putative metal binding site [ion binding]; other site 813001420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813001421 binding surface 813001422 TPR motif; other site 813001423 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 813001424 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 813001425 C-terminal domain interface [polypeptide binding]; other site 813001426 active site 813001427 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 813001428 active site 813001429 N-terminal domain interface [polypeptide binding]; other site 813001430 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 813001431 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 813001432 substrate binding pocket [chemical binding]; other site 813001433 membrane-bound complex binding site; other site 813001434 hinge residues; other site 813001435 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 813001436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813001437 S-adenosylmethionine binding site [chemical binding]; other site 813001438 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 813001439 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813001440 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 813001441 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 813001442 ligand binding site; other site 813001443 oligomer interface; other site 813001444 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 813001445 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 813001446 N-terminal domain interface [polypeptide binding]; other site 813001447 sulfate 1 binding site; other site 813001448 transcription termination factor Rho; Region: rho; TIGR00767 813001449 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 813001450 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 813001451 RNA binding site [nucleotide binding]; other site 813001452 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 813001453 multimer interface [polypeptide binding]; other site 813001454 Walker A motif; other site 813001455 ATP binding site [chemical binding]; other site 813001456 Walker B motif; other site 813001457 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 813001458 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 813001459 CoA-binding site [chemical binding]; other site 813001460 ATP-binding [chemical binding]; other site 813001461 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 813001462 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 813001463 tandem repeat interface [polypeptide binding]; other site 813001464 oligomer interface [polypeptide binding]; other site 813001465 active site residues [active] 813001466 TLC ATP/ADP transporter; Region: TLC; pfam03219 813001467 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 813001468 replicative DNA helicase; Provisional; Region: PRK06321 813001469 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 813001470 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 813001471 Walker A motif; other site 813001472 ATP binding site [chemical binding]; other site 813001473 Walker B motif; other site 813001474 DNA binding loops [nucleotide binding] 813001475 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 813001476 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 813001477 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 813001478 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 813001479 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 813001480 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 813001481 RuvA N terminal domain; Region: RuvA_N; pfam01330 813001482 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 813001483 active site 813001484 putative DNA-binding cleft [nucleotide binding]; other site 813001485 dimer interface [polypeptide binding]; other site 813001486 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 813001487 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 813001488 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 813001489 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 813001490 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 813001491 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 813001492 alphaNTD - beta interaction site [polypeptide binding]; other site 813001493 alphaNTD homodimer interface [polypeptide binding]; other site 813001494 alphaNTD - beta' interaction site [polypeptide binding]; other site 813001495 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 813001496 30S ribosomal protein S11; Validated; Region: PRK05309 813001497 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 813001498 30S ribosomal protein S13; Region: bact_S13; TIGR03631 813001499 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 813001500 SecY translocase; Region: SecY; pfam00344 813001501 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 813001502 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 813001503 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 813001504 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 813001505 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 813001506 5S rRNA interface [nucleotide binding]; other site 813001507 23S rRNA interface [nucleotide binding]; other site 813001508 L5 interface [polypeptide binding]; other site 813001509 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 813001510 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 813001511 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 813001512 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 813001513 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 813001514 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 813001515 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 813001516 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 813001517 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 813001518 RNA binding site [nucleotide binding]; other site 813001519 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 813001520 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 813001521 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 813001522 23S rRNA interface [nucleotide binding]; other site 813001523 putative translocon interaction site; other site 813001524 signal recognition particle (SRP54) interaction site; other site 813001525 L23 interface [polypeptide binding]; other site 813001526 trigger factor interaction site; other site 813001527 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 813001528 23S rRNA interface [nucleotide binding]; other site 813001529 5S rRNA interface [nucleotide binding]; other site 813001530 putative antibiotic binding site [chemical binding]; other site 813001531 L25 interface [polypeptide binding]; other site 813001532 L27 interface [polypeptide binding]; other site 813001533 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 813001534 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 813001535 G-X-X-G motif; other site 813001536 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 813001537 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 813001538 putative translocon binding site; other site 813001539 protein-rRNA interface [nucleotide binding]; other site 813001540 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 813001541 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 813001542 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 813001543 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 813001544 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 813001545 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 813001546 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 813001547 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 813001548 putative active site [active] 813001549 substrate binding site [chemical binding]; other site 813001550 putative cosubstrate binding site; other site 813001551 catalytic site [active] 813001552 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 813001553 substrate binding site [chemical binding]; other site 813001554 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 813001555 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 813001556 active site 813001557 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 813001558 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 813001559 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 813001560 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 813001561 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 813001562 putative active site [active] 813001563 catalytic triad [active] 813001564 putative dimer interface [polypeptide binding]; other site 813001565 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 813001566 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 813001567 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 813001568 active site 813001569 catalytic site [active] 813001570 substrate binding site [chemical binding]; other site 813001571 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 813001572 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 813001573 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 813001574 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 813001575 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813001576 catalytic residues [active] 813001577 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 813001578 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 813001579 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 813001580 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 813001581 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 813001582 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 813001583 dimer interface [polypeptide binding]; other site 813001584 anticodon binding site; other site 813001585 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 813001586 homodimer interface [polypeptide binding]; other site 813001587 motif 1; other site 813001588 active site 813001589 motif 2; other site 813001590 GAD domain; Region: GAD; pfam02938 813001591 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813001592 active site 813001593 motif 3; other site 813001594 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 813001595 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 813001596 dimer interface [polypeptide binding]; other site 813001597 motif 1; other site 813001598 active site 813001599 motif 2; other site 813001600 motif 3; other site 813001601 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 813001602 anticodon binding site; other site 813001603 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 813001604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813001605 putative substrate translocation pore; other site 813001606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813001607 TPR repeat; Region: TPR_11; pfam13414 813001608 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813001609 binding surface 813001610 TPR motif; other site 813001611 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 813001612 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 813001613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 813001614 Mg2+ binding site [ion binding]; other site 813001615 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 813001616 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 813001617 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 813001618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813001619 S-adenosylmethionine binding site [chemical binding]; other site 813001620 branched-chain amino acid uptake carrier; Region: livcs; TIGR00796 813001621 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 813001622 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813001623 ATP binding site [chemical binding]; other site 813001624 putative Mg++ binding site [ion binding]; other site 813001625 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813001626 ATP-binding site [chemical binding]; other site 813001627 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 813001628 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 813001629 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 813001630 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 813001631 lipoate synthase; Region: lipA; TIGR00510 813001632 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813001633 FeS/SAM binding site; other site 813001634 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 813001635 type III secretion system protein; Validated; Region: PRK06328 813001636 Flagellar assembly protein FliH; Region: FliH; pfam02108 813001637 type III secretion system protein; Reviewed; Region: PRK09617 813001638 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 813001639 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 813001640 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 813001641 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 813001642 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 813001643 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 813001644 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 813001645 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 813001646 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 813001647 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 813001648 Walker A motif; other site 813001649 ATP binding site [chemical binding]; other site 813001650 Walker B motif; other site 813001651 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 813001652 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813001653 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 813001654 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 813001655 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 813001656 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 813001657 active site 813001658 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 813001659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813001660 ATP binding site [chemical binding]; other site 813001661 Mg2+ binding site [ion binding]; other site 813001662 G-X-G motif; other site 813001663 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 813001664 ATP binding site [chemical binding]; other site 813001665 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 813001666 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 813001667 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813001668 binding surface 813001669 TPR motif; other site 813001670 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 813001671 EamA-like transporter family; Region: EamA; pfam00892 813001672 EamA-like transporter family; Region: EamA; pfam00892 813001673 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 813001674 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cd01616 813001675 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 813001676 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 813001677 active site 813001678 dimer interface [polypeptide binding]; other site 813001679 motif 1; other site 813001680 motif 2; other site 813001681 motif 3; other site 813001682 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 813001683 anticodon binding site; other site 813001684 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 813001685 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 813001686 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 813001687 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 813001688 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 813001689 active site 813001690 HIGH motif; other site 813001691 dimer interface [polypeptide binding]; other site 813001692 KMSKS motif; other site 813001693 excinuclease ABC subunit B; Provisional; Region: PRK05298 813001694 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813001695 ATP binding site [chemical binding]; other site 813001696 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813001697 nucleotide binding region [chemical binding]; other site 813001698 ATP-binding site [chemical binding]; other site 813001699 Ultra-violet resistance protein B; Region: UvrB; pfam12344 813001700 enolase; Provisional; Region: eno; PRK00077 813001701 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 813001702 dimer interface [polypeptide binding]; other site 813001703 metal binding site [ion binding]; metal-binding site 813001704 substrate binding pocket [chemical binding]; other site 813001705 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 813001706 HAMP domain; Region: HAMP; pfam00672 813001707 dimerization interface [polypeptide binding]; other site 813001708 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 813001709 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 813001710 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 813001711 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 813001712 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 813001713 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 813001714 Iron-sulfur protein interface; other site 813001715 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 813001716 proximal heme binding site [chemical binding]; other site 813001717 Iron-sulfur protein interface; other site 813001718 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 813001719 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 813001720 active site 813001721 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 813001722 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 813001723 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 813001724 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 813001725 DsbD alpha interface [polypeptide binding]; other site 813001726 catalytic residues [active] 813001727 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 813001728 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 813001729 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 813001730 translocation protein TolB; Provisional; Region: tolB; PRK01029 813001731 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813001732 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813001733 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813001734 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 813001735 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 813001736 ligand binding site [chemical binding]; other site 813001737 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 813001738 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813001739 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 813001740 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 813001741 dimer interface [polypeptide binding]; other site 813001742 decamer (pentamer of dimers) interface [polypeptide binding]; other site 813001743 catalytic triad [active] 813001744 peroxidatic and resolving cysteines [active] 813001745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 813001746 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 813001747 ligand binding site [chemical binding]; other site 813001748 active site 813001749 UGI interface [polypeptide binding]; other site 813001750 catalytic site [active] 813001751 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 813001752 Part of AAA domain; Region: AAA_19; pfam13245 813001753 Family description; Region: UvrD_C_2; pfam13538 813001754 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 813001755 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 813001756 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 813001757 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 813001758 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 813001759 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 813001760 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 813001761 folate binding site [chemical binding]; other site 813001762 NADP+ binding site [chemical binding]; other site 813001763 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 813001764 catalytic center binding site [active] 813001765 ATP binding site [chemical binding]; other site 813001766 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 813001767 dihydropteroate synthase; Region: DHPS; TIGR01496 813001768 substrate binding pocket [chemical binding]; other site 813001769 dimer interface [polypeptide binding]; other site 813001770 inhibitor binding site; inhibition site 813001771 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 813001772 homooctamer interface [polypeptide binding]; other site 813001773 active site 813001774 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 813001775 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 813001776 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 813001777 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 813001778 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 813001779 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 813001780 DNA binding residues [nucleotide binding] 813001781 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 813001782 Effector from type III secretion system; Region: Effector_1; pfam04518 813001783 Effector from type III secretion system; Region: Effector_1; pfam04518 813001784 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 813001785 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 813001786 MviN-like protein; Region: MVIN; pfam03023 813001787 endonuclease IV; Provisional; Region: PRK01060 813001788 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 813001789 AP (apurinic/apyrimidinic) site pocket; other site 813001790 DNA interaction; other site 813001791 Metal-binding active site; metal-binding site 813001792 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 813001793 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 813001794 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813001795 RNA binding surface [nucleotide binding]; other site 813001796 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 813001797 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 813001798 active site residue [active] 813001799 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 813001800 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 813001801 substrate binding pocket [chemical binding]; other site 813001802 chain length determination region; other site 813001803 substrate-Mg2+ binding site; other site 813001804 catalytic residues [active] 813001805 aspartate-rich region 1; other site 813001806 active site lid residues [active] 813001807 aspartate-rich region 2; other site 813001808 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 813001809 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 813001810 Thymidylate synthase complementing protein; Region: Thy1; cl03630 813001811 NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit; Region: nqrA; TIGR01936 813001812 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 813001813 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 813001814 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 813001815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813001816 homodimer interface [polypeptide binding]; other site 813001817 catalytic residue [active] 813001818 rod shape-determining protein MreC; Provisional; Region: PRK14872 813001819 rod shape-determining protein MreC; Region: MreC; pfam04085 813001820 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 813001821 Part of AAA domain; Region: AAA_19; pfam13245 813001822 Family description; Region: UvrD_C_2; pfam13538 813001823 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 813001824 Major Facilitator Superfamily; Region: MFS_1; pfam07690 813001825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813001826 putative substrate translocation pore; other site 813001827 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 813001828 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 813001829 FMN binding site [chemical binding]; other site 813001830 active site 813001831 catalytic residues [active] 813001832 substrate binding site [chemical binding]; other site 813001833 Predicted integral membrane protein [Function unknown]; Region: COG0762 813001834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813001835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813001836 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 813001837 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 813001838 recombinase A; Provisional; Region: recA; PRK09354 813001839 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 813001840 hexamer interface [polypeptide binding]; other site 813001841 Walker A motif; other site 813001842 ATP binding site [chemical binding]; other site 813001843 Walker B motif; other site 813001844 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 813001845 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 813001846 AAA domain; Region: AAA_30; pfam13604 813001847 Family description; Region: UvrD_C_2; pfam13538 813001848 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 813001849 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 813001850 Walker A/P-loop; other site 813001851 ATP binding site [chemical binding]; other site 813001852 Q-loop/lid; other site 813001853 ABC transporter signature motif; other site 813001854 Walker B; other site 813001855 D-loop; other site 813001856 H-loop/switch region; other site 813001857 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 813001858 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 813001859 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 813001860 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 813001861 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813001862 RNA binding surface [nucleotide binding]; other site 813001863 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 813001864 active site 813001865 hypothetical protein; Provisional; Region: PRK01064 813001866 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 813001867 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 813001868 DNA Topoisomerase IV; Region: TOP4c; smart00434 813001869 CAP-like domain; other site 813001870 active site 813001871 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 813001872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813001873 ATP binding site [chemical binding]; other site 813001874 Mg2+ binding site [ion binding]; other site 813001875 G-X-G motif; other site 813001876 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 813001877 ATP binding site [chemical binding]; other site 813001878 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 813001879 active site 813001880 putative metal-binding site [ion binding]; other site 813001881 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 813001882 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 813001883 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 813001884 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813001885 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 813001886 phosphopeptide binding site; other site 813001887 MARCKS family; Region: MARCKS; pfam02063 813001888 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 813001889 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 813001890 phosphopeptide binding site; other site 813001891 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 813001892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 813001893 binding surface 813001894 Tetratricopeptide repeat; Region: TPR_16; pfam13432 813001895 TPR motif; other site 813001896 type III secretion system ATPase; Provisional; Region: PRK06315 813001897 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813001898 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 813001899 Walker A motif/ATP binding site; other site 813001900 Walker B motif; other site 813001901 type III secretion system protein; Validated; Region: PRK05933 813001902 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 813001903 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 813001904 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813001905 active site 813001906 ATP binding site [chemical binding]; other site 813001907 substrate binding site [chemical binding]; other site 813001908 activation loop (A-loop); other site 813001909 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 813001910 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813001911 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813001912 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 813001913 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 813001914 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 813001915 ADP binding site [chemical binding]; other site 813001916 phosphagen binding site; other site 813001917 substrate specificity loop; other site 813001918 ribosome recycling factor; Reviewed; Region: frr; PRK00083 813001919 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 813001920 hinge region; other site 813001921 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 813001922 putative nucleotide binding site [chemical binding]; other site 813001923 uridine monophosphate binding site [chemical binding]; other site 813001924 homohexameric interface [polypeptide binding]; other site 813001925 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 813001926 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 813001927 Elongation factor TS; Region: EF_TS; pfam00889 813001928 Elongation factor TS; Region: EF_TS; pfam00889 813001929 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 813001930 rRNA interaction site [nucleotide binding]; other site 813001931 S8 interaction site; other site 813001932 putative laminin-1 binding site; other site 813001933 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 813001934 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 813001935 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 813001936 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 813001937 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 813001938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813001939 TPR motif; other site 813001940 Tetratricopeptide repeat; Region: TPR_16; pfam13432 813001941 binding surface 813001942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813001943 binding surface 813001944 TPR motif; other site 813001945 TPR repeat; Region: TPR_11; pfam13414 813001946 TPR repeat; Region: TPR_11; pfam13414 813001947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813001948 binding surface 813001949 TPR motif; other site 813001950 TPR repeat; Region: TPR_11; pfam13414 813001951 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 813001952 putative ABC transporter; Region: ycf24; CHL00085 813001953 FeS assembly ATPase SufC; Region: sufC; TIGR01978 813001954 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 813001955 Walker A/P-loop; other site 813001956 ATP binding site [chemical binding]; other site 813001957 Q-loop/lid; other site 813001958 ABC transporter signature motif; other site 813001959 Walker B; other site 813001960 D-loop; other site 813001961 H-loop/switch region; other site 813001962 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 813001963 FeS assembly protein SufD; Region: sufD; TIGR01981 813001964 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 813001965 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 813001966 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813001967 catalytic residue [active] 813001968 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 813001969 ParB-like nuclease domain; Region: ParBc; pfam02195 813001970 KorB domain; Region: KorB; pfam08535 813001971 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813001972 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 813001973 Walker A/P-loop; other site 813001974 ATP binding site [chemical binding]; other site 813001975 Q-loop/lid; other site 813001976 ABC transporter signature motif; other site 813001977 Walker B; other site 813001978 D-loop; other site 813001979 H-loop/switch region; other site 813001980 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813001981 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 813001982 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813001983 Walker A/P-loop; other site 813001984 ATP binding site [chemical binding]; other site 813001985 Q-loop/lid; other site 813001986 ABC transporter signature motif; other site 813001987 Walker B; other site 813001988 D-loop; other site 813001989 H-loop/switch region; other site 813001990 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813001991 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 813001992 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 813001993 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 813001994 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 813001995 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 813001996 minor groove reading motif; other site 813001997 helix-hairpin-helix signature motif; other site 813001998 substrate binding pocket [chemical binding]; other site 813001999 active site 813002000 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 813002001 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 813002002 trmE is a tRNA modification GTPase; Region: trmE; cd04164 813002003 G1 box; other site 813002004 GTP/Mg2+ binding site [chemical binding]; other site 813002005 Switch I region; other site 813002006 G2 box; other site 813002007 Switch II region; other site 813002008 G3 box; other site 813002009 G4 box; other site 813002010 G5 box; other site 813002011 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 813002012 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 813002013 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813002014 binding surface 813002015 TPR motif; other site 813002016 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 813002017 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 813002018 ATP binding site [chemical binding]; other site 813002019 putative Mg++ binding site [ion binding]; other site 813002020 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 813002021 Predicted GTPases [General function prediction only]; Region: COG1160 813002022 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 813002023 G1 box; other site 813002024 GTP/Mg2+ binding site [chemical binding]; other site 813002025 Switch I region; other site 813002026 G2 box; other site 813002027 Switch II region; other site 813002028 G3 box; other site 813002029 G4 box; other site 813002030 G5 box; other site 813002031 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 813002032 G1 box; other site 813002033 GTP/Mg2+ binding site [chemical binding]; other site 813002034 Switch I region; other site 813002035 G2 box; other site 813002036 G3 box; other site 813002037 Switch II region; other site 813002038 G4 box; other site 813002039 G5 box; other site 813002040 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 813002041 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 813002042 active site 813002043 NTP binding site [chemical binding]; other site 813002044 metal binding triad [ion binding]; metal-binding site 813002045 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 813002046 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 813002047 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 813002048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813002049 Walker A motif; other site 813002050 ATP binding site [chemical binding]; other site 813002051 Walker B motif; other site 813002052 arginine finger; other site 813002053 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 813002054 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 813002055 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 813002056 oligomer interface [polypeptide binding]; other site 813002057 active site residues [active] 813002058 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 813002059 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 813002060 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 813002061 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 813002062 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813002063 ATP binding site [chemical binding]; other site 813002064 putative Mg++ binding site [ion binding]; other site 813002065 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813002066 nucleotide binding region [chemical binding]; other site 813002067 ATP-binding site [chemical binding]; other site 813002068 rod shape-determining protein MreB; Provisional; Region: PRK13927 813002069 MreB and similar proteins; Region: MreB_like; cd10225 813002070 nucleotide binding site [chemical binding]; other site 813002071 Mg binding site [ion binding]; other site 813002072 putative protofilament interaction site [polypeptide binding]; other site 813002073 RodZ interaction site [polypeptide binding]; other site 813002074 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 813002075 active site 813002076 substrate-binding site [chemical binding]; other site 813002077 metal-binding site [ion binding] 813002078 GTP binding site [chemical binding]; other site 813002079 Effector from type III secretion system; Region: Effector_1; pfam04518 813002080 Effector from type III secretion system; Region: Effector_1; pfam04518 813002081 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 813002082 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 813002083 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 813002084 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 813002085 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 813002086 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 813002087 active site 813002088 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 813002089 type III secretion system ATPase; Validated; Region: PRK05922 813002090 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813002091 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 813002092 Walker A motif; other site 813002093 ATP binding site [chemical binding]; other site 813002094 Walker B motif; other site 813002095 type III secretion system protein; Validated; Region: PRK05934 813002096 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 813002097 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 813002098 active site 813002099 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 813002100 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 813002101 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813002102 catalytic residue [active] 813002103 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 813002104 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813002105 RNA binding surface [nucleotide binding]; other site 813002106 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 813002107 active site 813002108 biotin--protein ligase; Provisional; Region: PRK05935 813002109 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 813002110 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 813002111 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 813002112 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 813002113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 813002114 motif II; other site 813002115 CCC1-related protein family; Region: CCC1_like_1; cd02437 813002116 seryl-tRNA synthetase; Provisional; Region: PRK05431 813002117 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 813002118 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 813002119 dimer interface [polypeptide binding]; other site 813002120 active site 813002121 motif 1; other site 813002122 motif 2; other site 813002123 motif 3; other site 813002124 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 813002125 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 813002126 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 813002127 dimerization interface [polypeptide binding]; other site 813002128 active site 813002129 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 813002130 homopentamer interface [polypeptide binding]; other site 813002131 active site 813002132 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 813002133 substrate binding site [chemical binding]; other site 813002134 Proteins containing SET domain [General function prediction only]; Region: COG2940 813002135 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 813002136 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 813002137 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 813002138 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 813002139 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 813002140 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 813002141 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 813002142 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 813002143 catalytic loop [active] 813002144 iron binding site [ion binding]; other site 813002145 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 813002146 FAD binding pocket [chemical binding]; other site 813002147 FAD binding motif [chemical binding]; other site 813002148 phosphate binding motif [ion binding]; other site 813002149 beta-alpha-beta structure motif; other site 813002150 NAD binding pocket [chemical binding]; other site 813002151 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 813002152 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 813002153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813002154 S-adenosylmethionine binding site [chemical binding]; other site 813002155 Histone H1-like protein Hc1; Region: Hc1; pfam07432 813002156 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813002157 binding surface 813002158 TPR motif; other site 813002159 Tetratricopeptide repeat; Region: TPR_12; pfam13424 813002160 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 813002161 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 813002162 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 813002163 HemN C-terminal domain; Region: HemN_C; pfam06969 813002164 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 813002165 substrate binding site [chemical binding]; other site 813002166 active site 813002167 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 813002168 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 813002169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813002170 ATP binding site [chemical binding]; other site 813002171 putative Mg++ binding site [ion binding]; other site 813002172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813002173 nucleotide binding region [chemical binding]; other site 813002174 ATP-binding site [chemical binding]; other site 813002175 TRCF domain; Region: TRCF; pfam03461 813002176 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 813002177 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 813002178 motif 1; other site 813002179 active site 813002180 motif 2; other site 813002181 motif 3; other site 813002182 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 813002183 DHHA1 domain; Region: DHHA1; pfam02272 813002184 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 813002185 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 813002186 TPP-binding site [chemical binding]; other site 813002187 dimer interface [polypeptide binding]; other site 813002188 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 813002189 PYR/PP interface [polypeptide binding]; other site 813002190 dimer interface [polypeptide binding]; other site 813002191 TPP binding site [chemical binding]; other site 813002192 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813002193 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 813002194 elongation factor P; Validated; Region: PRK00529 813002195 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 813002196 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 813002197 RNA binding site [nucleotide binding]; other site 813002198 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 813002199 RNA binding site [nucleotide binding]; other site 813002200 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813002201 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 813002202 putative active site [active] 813002203 putative metal binding site [ion binding]; other site 813002204 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 813002205 active site 813002206 metal binding site [ion binding]; metal-binding site 813002207 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 813002208 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 813002209 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 813002210 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813002211 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813002212 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 813002213 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 813002214 Mg++ binding site [ion binding]; other site 813002215 putative catalytic motif [active] 813002216 putative substrate binding site [chemical binding]; other site 813002217 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 813002218 TrkA-N domain; Region: TrkA_N; pfam02254 813002219 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813002220 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813002221 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 813002222 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813002223 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813002224 cell division protein FtsW; Region: ftsW; TIGR02614 813002225 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 813002226 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 813002227 active site 813002228 homodimer interface [polypeptide binding]; other site 813002229 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 813002230 anti sigma factor interaction site; other site 813002231 regulatory phosphorylation site [posttranslational modification]; other site 813002232 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 813002233 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 813002234 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813002235 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 813002236 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 813002237 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 813002238 dimer interface [polypeptide binding]; other site 813002239 active site 813002240 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 813002241 active site 813002242 Ap4A binding cleft/pocket [chemical binding]; other site 813002243 P4 phosphate binding site; other site 813002244 nudix motif; other site 813002245 putative P2/P3 phosphate binding site [ion binding]; other site 813002246 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 813002247 dimer interface [polypeptide binding]; other site 813002248 substrate binding site [chemical binding]; other site 813002249 metal binding sites [ion binding]; metal-binding site 813002250 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 813002251 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 813002252 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 813002253 NAD binding site [chemical binding]; other site 813002254 Phe binding site; other site 813002255 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 813002256 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 813002257 active site 813002258 putative lithium-binding site [ion binding]; other site 813002259 substrate binding site [chemical binding]; other site 813002260 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 813002261 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 813002262 putative acyl-acceptor binding pocket; other site 813002263 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 813002264 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 813002265 acyl-activating enzyme (AAE) consensus motif; other site 813002266 AMP binding site [chemical binding]; other site 813002267 active site 813002268 CoA binding site [chemical binding]; other site 813002269 8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937 813002270 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 813002271 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813002272 catalytic residue [active] 813002273 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 813002274 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813002275 ATP binding site [chemical binding]; other site 813002276 putative Mg++ binding site [ion binding]; other site 813002277 helicase superfamily c-terminal domain; Region: HELICc; smart00490 813002278 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 813002279 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813002280 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 813002281 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 813002282 dimer interface [polypeptide binding]; other site 813002283 putative anticodon binding site; other site 813002284 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813002285 motif 1; other site 813002286 dimer interface [polypeptide binding]; other site 813002287 active site 813002288 motif 2; other site 813002289 motif 3; other site 813002290 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 813002291 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 813002292 active site 813002293 HIGH motif; other site 813002294 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 813002295 KMSKS motif; other site 813002296 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813002297 tRNA binding surface [nucleotide binding]; other site 813002298 anticodon binding site; other site 813002299 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 813002300 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813002301 ribonuclease P; Reviewed; Region: rnpA; PRK00730 813002302 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 813002303 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 813002304 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 813002305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 813002306 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 813002307 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 813002308 GIY-YIG motif/motif A; other site 813002309 active site 813002310 catalytic site [active] 813002311 putative DNA binding site [nucleotide binding]; other site 813002312 metal binding site [ion binding]; metal-binding site 813002313 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 813002314 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 813002315 MutS domain I; Region: MutS_I; pfam01624 813002316 MutS domain II; Region: MutS_II; pfam05188 813002317 MutS domain III; Region: MutS_III; pfam05192 813002318 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 813002319 Walker A/P-loop; other site 813002320 ATP binding site [chemical binding]; other site 813002321 Q-loop/lid; other site 813002322 ABC transporter signature motif; other site 813002323 Walker B; other site 813002324 D-loop; other site 813002325 H-loop/switch region; other site 813002326 DNA primase; Validated; Region: dnaG; PRK05667 813002327 CHC2 zinc finger; Region: zf-CHC2; pfam01807 813002328 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 813002329 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 813002330 active site 813002331 metal binding site [ion binding]; metal-binding site 813002332 interdomain interaction site; other site 813002333 glycyl-tRNA synthetase; Provisional; Region: PRK14908 813002334 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 813002335 dimer interface [polypeptide binding]; other site 813002336 motif 1; other site 813002337 active site 813002338 motif 2; other site 813002339 motif 3; other site 813002340 DALR anticodon binding domain; Region: DALR_1; pfam05746 813002341 glycogen synthase; Provisional; Region: glgA; PRK00654 813002342 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 813002343 ADP-binding pocket [chemical binding]; other site 813002344 homodimer interface [polypeptide binding]; other site 813002345 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 813002346 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 813002347 5S rRNA interface [nucleotide binding]; other site 813002348 CTC domain interface [polypeptide binding]; other site 813002349 L16 interface [polypeptide binding]; other site 813002350 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 813002351 putative active site [active] 813002352 catalytic residue [active] 813002353 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 813002354 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 813002355 Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359 813002356 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 813002357 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 813002358 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 813002359 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 813002360 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 813002361 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813002362 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813002363 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 813002364 putative acyl-acceptor binding pocket; other site 813002365 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 813002366 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 813002367 homodimer interface [polypeptide binding]; other site 813002368 oligonucleotide binding site [chemical binding]; other site 813002369 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 813002370 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 813002371 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813002372 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813002373 YtxH-like protein; Region: YtxH; cl02079 813002374 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 813002375 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 813002376 active site 813002377 substrate binding site [chemical binding]; other site 813002378 metal binding site [ion binding]; metal-binding site 813002379 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 813002380 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 813002381 glutaminase active site [active] 813002382 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 813002383 dimer interface [polypeptide binding]; other site 813002384 active site 813002385 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 813002386 dimer interface [polypeptide binding]; other site 813002387 active site 813002388 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 813002389 aromatic amino acid transport protein; Region: araaP; TIGR00837 813002390 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 813002391 aromatic amino acid transport protein; Region: araaP; TIGR00837 813002392 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 813002393 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 813002394 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 813002395 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 813002396 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 813002397 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 813002398 CoA-ligase; Region: Ligase_CoA; pfam00549 813002399 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 813002400 CoA binding domain; Region: CoA_binding; smart00881 813002401 CoA-ligase; Region: Ligase_CoA; pfam00549 813002402 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 813002403 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 813002404 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 813002405 protein binding site [polypeptide binding]; other site 813002406 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 813002407 protein binding site [polypeptide binding]; other site 813002408 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 813002409 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 813002410 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813002411 Peptidase M16C associated; Region: M16C_assoc; pfam08367 813002412 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813002413 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 813002414 RmuC family; Region: RmuC; pfam02646 813002415 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 813002416 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 813002417 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 813002418 ATP cone domain; Region: ATP-cone; pfam03477 813002419 ATP cone domain; Region: ATP-cone; pfam03477 813002420 Class I ribonucleotide reductase; Region: RNR_I; cd01679 813002421 active site 813002422 dimer interface [polypeptide binding]; other site 813002423 catalytic residues [active] 813002424 effector binding site; other site 813002425 R2 peptide binding site; other site 813002426 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 813002427 dimer interface [polypeptide binding]; other site 813002428 putative radical transfer pathway; other site 813002429 diiron center [ion binding]; other site 813002430 tyrosyl radical; other site 813002431 Putative methyltransferase; Region: Methyltransf_4; pfam02390 813002432 Methyltransferase domain; Region: Methyltransf_18; pfam12847 813002433 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 813002434 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 813002435 FAD binding domain; Region: FAD_binding_4; pfam01565 813002436 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 813002437 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 813002438 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 813002439 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 813002440 Ribosomal protein L35 [Translation, ribosomal structure and biogenesis]; Region: RpmI; COG0291 813002441 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 813002442 23S rRNA binding site [nucleotide binding]; other site 813002443 L21 binding site [polypeptide binding]; other site 813002444 L13 binding site [polypeptide binding]; other site 813002445 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 813002446 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 813002447 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 813002448 motif 1; other site 813002449 dimer interface [polypeptide binding]; other site 813002450 active site 813002451 motif 2; other site 813002452 motif 3; other site 813002453 Predicted permeases [General function prediction only]; Region: COG0795 813002454 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 813002455 Predicted permeases [General function prediction only]; Region: COG0795 813002456 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 813002457 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 813002458 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 813002459 Ligand Binding Site [chemical binding]; other site 813002460 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 813002461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813002462 Walker A motif; other site 813002463 ATP binding site [chemical binding]; other site 813002464 Walker B motif; other site 813002465 arginine finger; other site 813002466 Peptidase family M41; Region: Peptidase_M41; pfam01434 813002467 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 813002468 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 813002469 RNase E interface [polypeptide binding]; other site 813002470 trimer interface [polypeptide binding]; other site 813002471 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 813002472 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 813002473 RNase E interface [polypeptide binding]; other site 813002474 trimer interface [polypeptide binding]; other site 813002475 active site 813002476 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 813002477 putative nucleic acid binding region [nucleotide binding]; other site 813002478 G-X-X-G motif; other site 813002479 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 813002480 RNA binding site [nucleotide binding]; other site 813002481 domain interface; other site 813002482 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 813002483 16S/18S rRNA binding site [nucleotide binding]; other site 813002484 S13e-L30e interaction site [polypeptide binding]; other site 813002485 25S rRNA binding site [nucleotide binding]; other site 813002486 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 813002487 nucleoside/Zn binding site; other site 813002488 dimer interface [polypeptide binding]; other site 813002489 catalytic motif [active] 813002490 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813002491 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813002492 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813002493 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813002494 methionine aminopeptidase; Provisional; Region: PRK12318 813002495 SEC-C motif; Region: SEC-C; pfam02810 813002496 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 813002497 active site 813002498 MarC family integral membrane protein; Region: MarC; pfam01914 813002499 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 813002500 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 813002501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813002502 dimer interface [polypeptide binding]; other site 813002503 conserved gate region; other site 813002504 putative PBP binding loops; other site 813002505 ABC-ATPase subunit interface; other site 813002506 NMT1/THI5 like; Region: NMT1; pfam09084 813002507 fumarate hydratase, class II; Region: fumC_II; TIGR00979 813002508 Class II fumarases; Region: Fumarase_classII; cd01362 813002509 active site 813002510 tetramer interface [polypeptide binding]; other site 813002511 high affinity sulphate transporter 1; Region: sulP; TIGR00815 813002512 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 813002513 Sulfate transporter family; Region: Sulfate_transp; pfam00916 813002514 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 813002515 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 813002516 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 813002517 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 813002518 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 813002519 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 813002520 active site triad [active] 813002521 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 813002522 LytB protein; Region: LYTB; pfam02401 813002523 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 813002524 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 813002525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 813002526 binding surface 813002527 TPR motif; other site 813002528 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 813002529 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 813002530 active site 813002531 DNA binding site [nucleotide binding] 813002532 Int/Topo IB signature motif; other site 813002533 glycogen branching enzyme; Provisional; Region: PRK05402 813002534 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 813002535 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 813002536 active site 813002537 catalytic site [active] 813002538 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 813002539 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 813002540 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 813002541 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813002542 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813002543 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813002544 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813002545 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813002546 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813002547 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813002548 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1340853002549 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1340853002550 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 1340853002551 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1340853002552 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1340853002553 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 1340853002554 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1340853002555 GatB domain; Region: GatB_Yqey; pfam02637 1340853002556 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1340853002557 ribonuclease HIII; Region: rnhC; TIGR00716 1340853002558 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1340853002559 RNA/DNA hybrid binding site [nucleotide binding]; other site 1340853002560 active site 1340853002561 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1340853002562 Helix-turn-helix domain; Region: HTH_25; pfam13413 1340853002563 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906 1340853002564 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1340853002565 putative acyl-acceptor binding pocket; other site 1340853002566 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1340853002567 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1340853002568 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1340853002569 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1340853002570 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1340853002571 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1340853002572 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1340853002573 putative active site [active] 1340853002574 PhoH-like protein; Region: PhoH; pfam02562 1340853002575 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1340853002576 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1340853002577 HIGH motif; other site 1340853002578 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1340853002579 active site 1340853002580 KMSKS motif; other site 1340853002581 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1340853002582 tRNA binding surface [nucleotide binding]; other site 1340853002583 anticodon binding site; other site 1340853002584 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1340853002585 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1340853002586 Catalytic site [active] 1340853002587 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1340853002588 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1340853002589 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1340853002590 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1340853002591 PCRF domain; Region: PCRF; pfam03462 1340853002592 RF-1 domain; Region: RF-1; pfam00472 1340853002593 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1340853002594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340853002595 S-adenosylmethionine binding site [chemical binding]; other site 1340853002596 signal recognition particle protein; Provisional; Region: PRK10867 1340853002597 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1340853002598 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1340853002599 P loop; other site 1340853002600 GTP binding site [chemical binding]; other site 1340853002601 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1340853002602 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 1340853002603 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 1340853002604 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 1340853002605 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 1340853002606 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1340853002607 RNA/DNA hybrid binding site [nucleotide binding]; other site 1340853002608 active site 1340853002609 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1340853002610 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1340853002611 catalytic site [active] 1340853002612 G-X2-G-X-G-K; other site 1340853002613 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1340853002614 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1340853002615 active site 1340853002616 HIGH motif; other site 1340853002617 KMSKS motif; other site 1340853002618 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1340853002619 tRNA binding surface [nucleotide binding]; other site 1340853002620 anticodon binding site; other site 1340853002621 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1340853002622 AAA domain; Region: AAA_30; pfam13604 1340853002623 Family description; Region: UvrD_C_2; pfam13538 1340853002624 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1340853002625 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1340853002626 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 1340853002627 conserved cys residue [active] 1340853002628 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1340853002629 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1340853002630 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1340853002631 trimer interface [polypeptide binding]; other site 1340853002632 active site 1340853002633 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 1340853002634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340853002635 Walker A motif; other site 1340853002636 ATP binding site [chemical binding]; other site 1340853002637 Walker B motif; other site 1340853002638 arginine finger; other site 1340853002639 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1340853002640 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 1340853002641 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1340853002642 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1340853002643 dimer interface [polypeptide binding]; other site 1340853002644 ssDNA binding site [nucleotide binding]; other site 1340853002645 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1340853002646 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1340853002647 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1340853002648 interface (dimer of trimers) [polypeptide binding]; other site 1340853002649 Substrate-binding/catalytic site; other site 1340853002650 Zn-binding sites [ion binding]; other site 1340853002651 hypothetical protein; Provisional; Region: PRK05907 1340853002652 Predicted methyltransferases [General function prediction only]; Region: COG0313 1340853002653 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 1340853002654 putative SAM binding site [chemical binding]; other site 1340853002655 homodimer interface [polypeptide binding]; other site 1340853002656 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 1340853002657 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1340853002658 FeS/SAM binding site; other site 1340853002659 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 1340853002660 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1340853002661 TPP-binding site [chemical binding]; other site 1340853002662 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1340853002663 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1340853002664 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1340853002665 E3 interaction surface; other site 1340853002666 lipoyl attachment site [posttranslational modification]; other site 1340853002667 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1340853002668 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 1340853002669 ADP-ribose binding site [chemical binding]; other site 1340853002670 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1340853002671 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1340853002672 catalytic loop [active] 1340853002673 iron binding site [ion binding]; other site 1340853002674 type III secretion system protein; Validated; Region: PRK05910 1340853002675 FHIPEP family; Region: FHIPEP; pfam00771 1340853002676 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 1340853002677 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1340853002678 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1340853002679 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1340853002680 DNA binding residues [nucleotide binding] 1340853002681 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1340853002682 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1340853002683 active site 1340853002684 HIGH motif; other site 1340853002685 dimer interface [polypeptide binding]; other site 1340853002686 KMSKS motif; other site 1340853002687 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1340853002688 RNA binding surface [nucleotide binding]; other site 1340853002689 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 1340853002690 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1340853002691 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1340853002692 GTP-binding protein LepA; Provisional; Region: PRK05433 1340853002693 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1340853002694 G1 box; other site 1340853002695 putative GEF interaction site [polypeptide binding]; other site 1340853002696 GTP/Mg2+ binding site [chemical binding]; other site 1340853002697 Switch I region; other site 1340853002698 G2 box; other site 1340853002699 G3 box; other site 1340853002700 Switch II region; other site 1340853002701 G4 box; other site 1340853002702 G5 box; other site 1340853002703 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1340853002704 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1340853002705 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1340853002706 ADP/ATP carrier protein family; Region: AAA; TIGR00769 1340853002707 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1340853002708 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1340853002709 intersubunit interface [polypeptide binding]; other site 1340853002710 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1340853002711 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1340853002712 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1340853002713 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1340853002714 ABC-ATPase subunit interface; other site 1340853002715 dimer interface [polypeptide binding]; other site 1340853002716 putative PBP binding regions; other site 1340853002717 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1340853002718 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1340853002719 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1340853002720 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1340853002721 ABC-ATPase subunit interface; other site 1340853002722 dimer interface [polypeptide binding]; other site 1340853002723 putative PBP binding regions; other site 1340853002724 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 1340853002725 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1340853002726 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1340853002727 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1340853002728 RIP metalloprotease RseP; Region: TIGR00054 1340853002729 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1340853002730 active site 1340853002731 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1340853002732 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1340853002733 putative substrate binding region [chemical binding]; other site 1340853002734 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1340853002735 Putative serine esterase (DUF676); Region: DUF676; pfam05057 1340853002736 recF protein; Region: recf; TIGR00611 1340853002737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340853002738 Walker A/P-loop; other site 1340853002739 ATP binding site [chemical binding]; other site 1340853002740 Q-loop/lid; other site 1340853002741 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340853002742 ABC transporter signature motif; other site 1340853002743 Walker B; other site 1340853002744 DNA polymerase III subunit beta; Validated; Region: PRK05643 1340853002745 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1340853002746 putative DNA binding surface [nucleotide binding]; other site 1340853002747 dimer interface [polypeptide binding]; other site 1340853002748 beta-clamp/clamp loader binding surface; other site 1340853002749 beta-clamp/translesion DNA polymerase binding surface; other site 1340853002750 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1340853002751 SmpB-tmRNA interface; other site 1340853002752 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1340853002753 ApbE family; Region: ApbE; pfam02424 1340853002754 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 1340853002755 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1340853002756 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1340853002757 homodimer interface [polypeptide binding]; other site 1340853002758 NADP binding site [chemical binding]; other site 1340853002759 substrate binding site [chemical binding]; other site 1340853002760 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1340853002761 PLD-like domain; Region: PLDc_2; pfam13091 1340853002762 putative active site [active] 1340853002763 catalytic site [active] 1340853002764 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 1340853002765 PLD-like domain; Region: PLDc_2; pfam13091 1340853002766 putative active site [active] 1340853002767 catalytic site [active] 1340853002768 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1340853002769 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1340853002770 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1340853002771 4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446 1340853002772 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 1340853002773 HrpJ-like domain; Region: HrpJ; cl15454 1340853002774 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 1340853002775 FHIPEP family; Region: FHIPEP; pfam00771 1340853002776 type III secretion system protein; Validated; Region: PRK06298 1340853002777 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1340853002778 GTP-binding protein YchF; Reviewed; Region: PRK09601 1340853002779 YchF GTPase; Region: YchF; cd01900 1340853002780 G1 box; other site 1340853002781 GTP/Mg2+ binding site [chemical binding]; other site 1340853002782 Switch I region; other site 1340853002783 G2 box; other site 1340853002784 Switch II region; other site 1340853002785 G3 box; other site 1340853002786 G4 box; other site 1340853002787 G5 box; other site 1340853002788 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1340853002789 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1340853002790 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1340853002791 active site 1340853002792 Riboflavin kinase; Region: Flavokinase; smart00904 1340853002793 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 1340853002794 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1340853002795 RNA binding site [nucleotide binding]; other site 1340853002796 active site 1340853002797 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1340853002798 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1340853002799 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1340853002800 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1340853002801 G1 box; other site 1340853002802 putative GEF interaction site [polypeptide binding]; other site 1340853002803 GTP/Mg2+ binding site [chemical binding]; other site 1340853002804 Switch I region; other site 1340853002805 G2 box; other site 1340853002806 G3 box; other site 1340853002807 Switch II region; other site 1340853002808 G4 box; other site 1340853002809 G5 box; other site 1340853002810 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1340853002811 Translation-initiation factor 2; Region: IF-2; pfam11987 1340853002812 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1340853002813 transcription termination factor NusA; Region: NusA; TIGR01953 1340853002814 NusA N-terminal domain; Region: NusA_N; pfam08529 1340853002815 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1340853002816 RNA binding site [nucleotide binding]; other site 1340853002817 homodimer interface [polypeptide binding]; other site 1340853002818 NusA-like KH domain; Region: KH_5; pfam13184 1340853002819 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1340853002820 G-X-X-G motif; other site 1340853002821 ribosomal protein S1; Region: rpsA; TIGR00717 1340853002822 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1340853002823 RNA binding site [nucleotide binding]; other site 1340853002824 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1340853002825 RNA binding site [nucleotide binding]; other site 1340853002826 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1340853002827 RNA binding site [nucleotide binding]; other site 1340853002828 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1340853002829 RNA binding site [nucleotide binding]; other site 1340853002830 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1340853002831 RNA binding site [nucleotide binding]; other site 1340853002832 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1340853002833 RNA binding site [nucleotide binding]; other site 1340853002834 domain interface; other site 1340853002835 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1340853002836 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1340853002837 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1340853002838 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1340853002839 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 1340853002840 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1340853002841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1340853002842 active site 1340853002843 motif I; other site 1340853002844 motif II; other site 1340853002845 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 1340853002846 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1340853002847 NAD binding site [chemical binding]; other site 1340853002848 homotetramer interface [polypeptide binding]; other site 1340853002849 homodimer interface [polypeptide binding]; other site 1340853002850 substrate binding site [chemical binding]; other site 1340853002851 active site 1340853002852 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1340853002853 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1340853002854 RNA binding surface [nucleotide binding]; other site 1340853002855 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1340853002856 active site 1340853002857 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 1340853002858 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1340853002859 minor groove reading motif; other site 1340853002860 helix-hairpin-helix signature motif; other site 1340853002861 substrate binding pocket [chemical binding]; other site 1340853002862 active site 1340853002863 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1340853002864 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1340853002865 DNA binding and oxoG recognition site [nucleotide binding] 1340853002866 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1340853002867 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1340853002868 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1340853002869 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1340853002870 ring oligomerisation interface [polypeptide binding]; other site 1340853002871 ATP/Mg binding site [chemical binding]; other site 1340853002872 stacking interactions; other site 1340853002873 hinge regions; other site 1340853002874 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1340853002875 oligomerisation interface [polypeptide binding]; other site 1340853002876 mobile loop; other site 1340853002877 roof hairpin; other site 1340853002878 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1340853002879 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1340853002880 active site 1340853002881 Zn binding site [ion binding]; other site 1340853002882 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1340853002883 Clp amino terminal domain; Region: Clp_N; pfam02861 1340853002884 Clp amino terminal domain; Region: Clp_N; pfam02861 1340853002885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340853002886 Walker A motif; other site 1340853002887 ATP binding site [chemical binding]; other site 1340853002888 Walker B motif; other site 1340853002889 arginine finger; other site 1340853002890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340853002891 Walker A motif; other site 1340853002892 ATP binding site [chemical binding]; other site 1340853002893 Walker B motif; other site 1340853002894 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1340853002895 Uncharacterized conserved protein [Function unknown]; Region: COG2912 1340853002896 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1340853002897 IncA protein; Region: IncA; pfam04156 1340853002898 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 1340853002899 elongation factor P; Provisional; Region: PRK12426 1340853002900 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1340853002901 RNA binding site [nucleotide binding]; other site 1340853002902 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1340853002903 RNA binding site [nucleotide binding]; other site 1340853002904 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1340853002905 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1340853002906 carboxyltransferase (CT) interaction site; other site 1340853002907 biotinylation site [posttranslational modification]; other site 1340853002908 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1340853002909 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1340853002910 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1340853002911 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1340853002912 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1340853002913 23S rRNA interface [nucleotide binding]; other site 1340853002914 L3 interface [polypeptide binding]; other site 1340853002915 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1340853002916 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1340853002917 NlpC/P60 family; Region: NLPC_P60; cl17555 1340853002918 adenylate kinase; Reviewed; Region: adk; PRK00279 1340853002919 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1340853002920 AMP-binding site [chemical binding]; other site 1340853002921 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1340853002922 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1340853002923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1340853002924 dimer interface [polypeptide binding]; other site 1340853002925 conserved gate region; other site 1340853002926 putative PBP binding loops; other site 1340853002927 ABC-ATPase subunit interface; other site 1340853002928 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1340853002929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340853002930 Walker A/P-loop; other site 1340853002931 ATP binding site [chemical binding]; other site 1340853002932 Q-loop/lid; other site 1340853002933 ABC transporter signature motif; other site 1340853002934 Walker B; other site 1340853002935 D-loop; other site 1340853002936 H-loop/switch region; other site 1340853002937 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1340853002938 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1340853002939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340853002940 S-adenosylmethionine binding site [chemical binding]; other site 1340853002941 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1340853002942 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1340853002943 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1340853002944 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1340853002945 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1340853002946 active site 1340853002947 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1340853002948 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1340853002949 conserved hypothetical integral membrane protein; Region: TIGR00697 1340853002950 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1340853002951 SEC-C motif; Region: SEC-C; pfam02810 1340853002952 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1340853002953 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1340853002954 active site 1340853002955 ATP binding site [chemical binding]; other site 1340853002956 substrate binding site [chemical binding]; other site 1340853002957 activation loop (A-loop); other site 1340853002958 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1340853002959 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1340853002960 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1340853002961 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 1340853002962 nucleotide binding pocket [chemical binding]; other site 1340853002963 K-X-D-G motif; other site 1340853002964 catalytic site [active] 1340853002965 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1340853002966 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1340853002967 Helix-hairpin-helix motif; Region: HHH; pfam00633 1340853002968 helix-hairpin-helix signature motif; other site 1340853002969 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1340853002970 Dimer interface [polypeptide binding]; other site 1340853002971 BRCT sequence motif; other site 1340853002972 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1340853002973 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1340853002974 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1340853002975 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1340853002976 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1340853002977 FtsX-like permease family; Region: FtsX; pfam02687 1340853002978 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1340853002979 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1340853002980 Walker A/P-loop; other site 1340853002981 ATP binding site [chemical binding]; other site 1340853002982 Q-loop/lid; other site 1340853002983 ABC transporter signature motif; other site 1340853002984 Walker B; other site 1340853002985 D-loop; other site 1340853002986 H-loop/switch region; other site 1340853002987 membrane-attack complex / perforin; Region: MACPF; smart00457 1340853002988 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 1340853002989 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1340853002990 PLD-like domain; Region: PLDc_2; pfam13091 1340853002991 putative active site [active] 1340853002992 catalytic site [active] 1340853002993 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 1340853002994 PLD-like domain; Region: PLDc_2; pfam13091 1340853002995 putative active site [active] 1340853002996 catalytic site [active] 1340853002997 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1340853002998 PLD-like domain; Region: PLDc_2; pfam13091 1340853002999 putative active site [active] 1340853003000 catalytic site [active] 1340853003001 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1340853003002 PLD-like domain; Region: PLDc_2; pfam13091 1340853003003 putative active site [active] 1340853003004 catalytic site [active] 1340853003005 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1340853003006 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 1340853003007 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1340853003008 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 1340853003009 trp operon repressor, proteobacterial; Region: TrpR; TIGR01321 1340853003010 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1340853003011 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1340853003012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1340853003013 catalytic residue [active] 1340853003014 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1340853003015 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1340853003016 substrate binding site [chemical binding]; other site 1340853003017 active site 1340853003018 catalytic residues [active] 1340853003019 heterodimer interface [polypeptide binding]; other site 1340853003020 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1340853003021 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1340853003022 peptide binding site [polypeptide binding]; other site 1340853003023 putative disulfide oxidoreductase; Provisional; Region: PRK00611 1340853003024 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 1340853003025 putative active site [active] 1340853003026 redox center [active] 1340853003027 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1340853003028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340853003029 Walker A/P-loop; other site 1340853003030 ATP binding site [chemical binding]; other site 1340853003031 Q-loop/lid; other site 1340853003032 ABC transporter signature motif; other site 1340853003033 Walker B; other site 1340853003034 D-loop; other site 1340853003035 H-loop/switch region; other site 1340853003036 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1340853003037 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1340853003038 Ligand binding site; other site 1340853003039 oligomer interface; other site 1340853003040 CTP synthetase; Validated; Region: pyrG; PRK05380 1340853003041 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1340853003042 Catalytic site [active] 1340853003043 active site 1340853003044 UTP binding site [chemical binding]; other site 1340853003045 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1340853003046 active site 1340853003047 putative oxyanion hole; other site 1340853003048 catalytic triad [active] 1340853003049 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 1340853003050 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1340853003051 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1340853003052 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1340853003053 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1340853003054 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1340853003055 putative active site [active] 1340853003056 DNA polymerase III subunit delta'; Validated; Region: PRK05917 1340853003057 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1340853003058 thymidylate kinase; Validated; Region: tmk; PRK00698 1340853003059 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1340853003060 TMP-binding site; other site 1340853003061 ATP-binding site [chemical binding]; other site 1340853003062 DNA gyrase, A subunit; Region: gyrA; TIGR01063 1340853003063 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1340853003064 CAP-like domain; other site 1340853003065 active site 1340853003066 primary dimer interface [polypeptide binding]; other site 1340853003067 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1340853003068 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1340853003069 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1340853003070 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1340853003071 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1340853003072 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1340853003073 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1340853003074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1340853003075 ATP binding site [chemical binding]; other site 1340853003076 Mg2+ binding site [ion binding]; other site 1340853003077 G-X-G motif; other site 1340853003078 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1340853003079 anchoring element; other site 1340853003080 dimer interface [polypeptide binding]; other site 1340853003081 ATP binding site [chemical binding]; other site 1340853003082 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1340853003083 active site 1340853003084 putative metal-binding site [ion binding]; other site 1340853003085 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1340853003086 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1340853003087 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 1340853003088 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1340853003089 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1340853003090 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1340853003091 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1340853003092 Divalent cation transporter; Region: MgtE; pfam01769 1340853003093 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 1340853003094 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1340853003095 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1340853003096 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1340853003097 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1340853003098 peptide binding site [polypeptide binding]; other site 1340853003099 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1340853003100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1340853003101 dimer interface [polypeptide binding]; other site 1340853003102 conserved gate region; other site 1340853003103 putative PBP binding loops; other site 1340853003104 ABC-ATPase subunit interface; other site 1340853003105 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1340853003106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1340853003107 dimer interface [polypeptide binding]; other site 1340853003108 conserved gate region; other site 1340853003109 putative PBP binding loops; other site 1340853003110 ABC-ATPase subunit interface; other site 1340853003111 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1340853003112 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1340853003113 Walker A/P-loop; other site 1340853003114 ATP binding site [chemical binding]; other site 1340853003115 Q-loop/lid; other site 1340853003116 ABC transporter signature motif; other site 1340853003117 Walker B; other site 1340853003118 D-loop; other site 1340853003119 H-loop/switch region; other site 1340853003120 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1340853003121 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1340853003122 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1340853003123 Walker A/P-loop; other site 1340853003124 ATP binding site [chemical binding]; other site 1340853003125 Q-loop/lid; other site 1340853003126 ABC transporter signature motif; other site 1340853003127 Walker B; other site 1340853003128 D-loop; other site 1340853003129 H-loop/switch region; other site 1340853003130 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1340853003131 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1340853003132 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1340853003133 transmembrane helices; other site 1340853003134 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 1340853003135 active site 1340853003136 ADP/pyrophosphate binding site [chemical binding]; other site 1340853003137 dimerization interface [polypeptide binding]; other site 1340853003138 allosteric effector site; other site 1340853003139 fructose-1,6-bisphosphate binding site; other site 1340853003140 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1340853003141 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1340853003142 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 1340853003143 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 1340853003144 active site 1340853003145 ADP/pyrophosphate binding site [chemical binding]; other site 1340853003146 dimerization interface [polypeptide binding]; other site 1340853003147 allosteric effector site; other site 1340853003148 fructose-1,6-bisphosphate binding site; other site 1340853003149 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 1340853003150 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1340853003151 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1340853003152 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1340853003153 HIGH motif; other site 1340853003154 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1340853003155 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1340853003156 active site 1340853003157 KMSKS motif; other site 1340853003158 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1340853003159 tRNA binding surface [nucleotide binding]; other site 1340853003160 Putative transcriptional regulator [Transcription]; Region: COG1678 1340853003161 Uncharacterized conserved protein [Function unknown]; Region: COG1259 1340853003162 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1340853003163 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1340853003164 active site 1340853003165 dimer interface [polypeptide binding]; other site 1340853003166 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1340853003167 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1340853003168 putative active site; other site 1340853003169 catalytic residue [active] 1340853003170 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1340853003171 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1340853003172 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1340853003173 Ligand Binding Site [chemical binding]; other site 1340853003174 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 1340853003175 prenyltransferase; Reviewed; Region: ubiA; PRK12876 1340853003176 UbiA prenyltransferase family; Region: UbiA; pfam01040 1340853003177 aromatic acid decarboxylase; Validated; Region: PRK05920 1340853003178 Flavoprotein; Region: Flavoprotein; pfam02441 1340853003179 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1340853003180 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1340853003181 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1340853003182 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1340853003183 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1340853003184 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1340853003185 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1340853003186 Na2 binding site [ion binding]; other site 1340853003187 putative substrate binding site 1 [chemical binding]; other site 1340853003188 Na binding site 1 [ion binding]; other site 1340853003189 putative substrate binding site 2 [chemical binding]; other site 1340853003190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340853003191 putative substrate translocation pore; other site 1340853003192 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1340853003193 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1340853003194 ligand binding site [chemical binding]; other site 1340853003195 flexible hinge region; other site 1340853003196 acyl carrier protein; Provisional; Region: acpP; PRK00982 1340853003197 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1340853003198 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1340853003199 NAD(P) binding site [chemical binding]; other site 1340853003200 homotetramer interface [polypeptide binding]; other site 1340853003201 homodimer interface [polypeptide binding]; other site 1340853003202 active site 1340853003203 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1340853003204 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1340853003205 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 1340853003206 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1340853003207 dimer interface [polypeptide binding]; other site 1340853003208 active site 1340853003209 CoA binding pocket [chemical binding]; other site 1340853003210 recombination protein RecR; Region: recR; TIGR00615 1340853003211 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1340853003212 putative active site [active] 1340853003213 putative metal-binding site [ion binding]; other site 1340853003214 tetramer interface [polypeptide binding]; other site 1340853003215 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 1340853003216 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1340853003217 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1340853003218 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1340853003219 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1340853003220 Surface antigen; Region: Bac_surface_Ag; pfam01103 1340853003221 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 1340853003222 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 1340853003223 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1340853003224 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1340853003225 trimer interface [polypeptide binding]; other site 1340853003226 active site 1340853003227 UDP-GlcNAc binding site [chemical binding]; other site 1340853003228 lipid binding site [chemical binding]; lipid-binding site 1340853003229 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1340853003230 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1340853003231 tetramer interface [polypeptide binding]; other site 1340853003232 TPP-binding site [chemical binding]; other site 1340853003233 heterodimer interface [polypeptide binding]; other site 1340853003234 phosphorylation loop region [posttranslational modification] 1340853003235 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1340853003236 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1340853003237 alpha subunit interface [polypeptide binding]; other site 1340853003238 TPP binding site [chemical binding]; other site 1340853003239 heterodimer interface [polypeptide binding]; other site 1340853003240 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1340853003241 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 1340853003242 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1340853003243 E3 interaction surface; other site 1340853003244 lipoyl attachment site [posttranslational modification]; other site 1340853003245 e3 binding domain; Region: E3_binding; pfam02817 1340853003246 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1340853003247 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1340853003248 homodimer interface [polypeptide binding]; other site 1340853003249 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1340853003250 active site pocket [active] 1340853003251 chromosomal replication initiation protein; Provisional; Region: PRK12422 1340853003252 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1340853003253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340853003254 Walker A motif; other site 1340853003255 ATP binding site [chemical binding]; other site 1340853003256 Walker B motif; other site 1340853003257 arginine finger; other site 1340853003258 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1340853003259 DnaA box-binding interface [nucleotide binding]; other site 1340853003260 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 1340853003261 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1340853003262 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1340853003263 CAAX protease self-immunity; Region: Abi; pfam02517 1340853003264 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1340853003265 homodimer interface [polypeptide binding]; other site 1340853003266 metal binding site [ion binding]; metal-binding site 1340853003267 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1340853003268 Domain of unknown function DUF21; Region: DUF21; pfam01595 1340853003269 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1340853003270 Transporter associated domain; Region: CorC_HlyC; smart01091 1340853003271 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1340853003272 Domain of unknown function DUF21; Region: DUF21; pfam01595 1340853003273 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1340853003274 Transporter associated domain; Region: CorC_HlyC; smart01091 1340853003275 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1340853003276 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1340853003277 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1340853003278 catalytic residue [active] 1340853003279 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1340853003280 Protein phosphatase 2C; Region: PP2C; pfam00481 1340853003281 active site 1340853003282 Uncharacterized conserved protein [Function unknown]; Region: COG5465 1340853003283 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 1340853003284 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1340853003285 active site 1340853003286 catalytic site [active] 1340853003287 substrate binding site [chemical binding]; other site 1340853003288 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 1340853003289 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 1340853003290 nucleosidase; Provisional; Region: PRK05634 1340853003291 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1340853003292 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1340853003293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340853003294 Walker A/P-loop; other site 1340853003295 ATP binding site [chemical binding]; other site 1340853003296 Q-loop/lid; other site 1340853003297 ABC transporter signature motif; other site 1340853003298 Walker B; other site 1340853003299 D-loop; other site 1340853003300 H-loop/switch region; other site 1340853003301 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1340853003302 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1340853003303 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1340853003304 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1340853003305 active site 1340853003306 metal binding site [ion binding]; metal-binding site 1340853003307 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 1340853003308 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1340853003309 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1340853003310 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1340853003311 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1340853003312 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1340853003313 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1340853003314 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1340853003315 MraW methylase family; Region: Methyltransf_5; pfam01795 1340853003316 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1340853003317 TPR motif; other site 1340853003318 binding surface 1340853003319 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1340853003320 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1340853003321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340853003322 Walker A motif; other site 1340853003323 ATP binding site [chemical binding]; other site 1340853003324 Walker B motif; other site 1340853003325 arginine finger; other site 1340853003326 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1340853003327 DnaA box-binding interface [nucleotide binding]; other site 1340853003328 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1340853003329 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1340853003330 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 1340853003331 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 1340853003332 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 1340853003333 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 1340853003334 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 1340853003335 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1340853003336 lipoyl attachment site [posttranslational modification]; other site 1340853003337 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 1340853003338 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1340853003339 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1340853003340 putative active site [active] 1340853003341 catalytic site [active] 1340853003342 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1340853003343 putative active site [active] 1340853003344 catalytic site [active] 1340853003345 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1340853003346 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1340853003347 Clp amino terminal domain; Region: Clp_N; pfam02861 1340853003348 Clp amino terminal domain; Region: Clp_N; pfam02861 1340853003349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340853003350 Walker A motif; other site 1340853003351 ATP binding site [chemical binding]; other site 1340853003352 Walker B motif; other site 1340853003353 arginine finger; other site 1340853003354 UvrB/uvrC motif; Region: UVR; pfam02151 1340853003355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340853003356 Walker A motif; other site 1340853003357 ATP binding site [chemical binding]; other site 1340853003358 Walker B motif; other site 1340853003359 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1340853003360 Helix-turn-helix domain; Region: HTH_17; pfam12728 1340853003361 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1340853003362 active site 1340853003363 phosphorylation site [posttranslational modification] 1340853003364 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1340853003365 active site 1340853003366 phosphorylation site [posttranslational modification] 1340853003367 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1340853003368 trimer interface [polypeptide binding]; other site 1340853003369 active site 1340853003370 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1340853003371 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1340853003372 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1340853003373 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1340853003374 active site 1340853003375 substrate binding site [chemical binding]; other site 1340853003376 metal binding site [ion binding]; metal-binding site 1340853003377 ribonuclease III; Reviewed; Region: rnc; PRK00102 1340853003378 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1340853003379 dimerization interface [polypeptide binding]; other site 1340853003380 active site 1340853003381 metal binding site [ion binding]; metal-binding site 1340853003382 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1340853003383 dsRNA binding site [nucleotide binding]; other site 1340853003384 DNA repair protein RadA; Provisional; Region: PRK11823 1340853003385 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1340853003386 Walker A motif/ATP binding site; other site 1340853003387 ATP binding site [chemical binding]; other site 1340853003388 Walker B motif; other site 1340853003389 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1340853003390 porphobilinogen deaminase; Provisional; Region: PRK01066 1340853003391 Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379 1340853003392 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 1340853003393 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1340853003394 active site 1340853003395 ATP binding site [chemical binding]; other site 1340853003396 substrate binding site [chemical binding]; other site 1340853003397 activation loop (A-loop); other site 1340853003398 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1340853003399 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1340853003400 HIGH motif; other site 1340853003401 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1340853003402 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1340853003403 active site 1340853003404 KMSKS motif; other site 1340853003405 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1340853003406 tRNA binding surface [nucleotide binding]; other site 1340853003407 anticodon binding site; other site 1340853003408 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1340853003409 V-type ATP synthase subunit K; Provisional; Region: PRK09621 1340853003410 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 1340853003411 V-type ATP synthase subunit I; Validated; Region: PRK05771 1340853003412 Protein of unknown function (DUF1319); Region: DUF1319; pfam07028 1340853003413 V-type ATP synthase subunit D; Provisional; Region: PRK02195 1340853003414 V-type ATP synthase subunit B; Provisional; Region: PRK02118 1340853003415 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1340853003416 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 1340853003417 Walker A motif homologous position; other site 1340853003418 Walker B motif; other site 1340853003419 V-type ATP synthase subunit A; Provisional; Region: PRK04192 1340853003420 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1340853003421 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 1340853003422 Walker A motif/ATP binding site; other site 1340853003423 Walker B motif; other site 1340853003424 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1340853003425 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 1340853003426 V-type ATP synthase subunit E; Provisional; Region: PRK01005 1340853003427 V-type ATP synthase subunit E; Provisional; Region: PRK01558 1340853003428 transaldolase-like protein; Provisional; Region: PTZ00411 1340853003429 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1340853003430 active site 1340853003431 dimer interface [polypeptide binding]; other site 1340853003432 catalytic residue [active] 1340853003433 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1340853003434 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 1340853003435 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1340853003436 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1340853003437 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1340853003438 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1340853003439 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1340853003440 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1340853003441 DNA binding site [nucleotide binding] 1340853003442 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1340853003443 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 1340853003444 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1340853003445 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1340853003446 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 1340853003447 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1340853003448 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1340853003449 RPB12 interaction site [polypeptide binding]; other site 1340853003450 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1340853003451 RPB3 interaction site [polypeptide binding]; other site 1340853003452 RPB1 interaction site [polypeptide binding]; other site 1340853003453 RPB11 interaction site [polypeptide binding]; other site 1340853003454 RPB10 interaction site [polypeptide binding]; other site 1340853003455 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1340853003456 L11 interface [polypeptide binding]; other site 1340853003457 putative EF-Tu interaction site [polypeptide binding]; other site 1340853003458 putative EF-G interaction site [polypeptide binding]; other site 1340853003459 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1340853003460 23S rRNA interface [nucleotide binding]; other site 1340853003461 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1340853003462 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1340853003463 mRNA/rRNA interface [nucleotide binding]; other site 1340853003464 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1340853003465 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1340853003466 putative thiostrepton binding site; other site 1340853003467 23S rRNA interface [nucleotide binding]; other site 1340853003468 L7/L12 interface [polypeptide binding]; other site 1340853003469 L25 interface [polypeptide binding]; other site 1340853003470 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1340853003471 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 1340853003472 putative homodimer interface [polypeptide binding]; other site 1340853003473 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1340853003474 heterodimer interface [polypeptide binding]; other site 1340853003475 homodimer interface [polypeptide binding]; other site 1340853003476 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 1340853003477 elongation factor Tu; Reviewed; Region: PRK12735 1340853003478 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1340853003479 G1 box; other site 1340853003480 GEF interaction site [polypeptide binding]; other site 1340853003481 GTP/Mg2+ binding site [chemical binding]; other site 1340853003482 Switch I region; other site 1340853003483 G2 box; other site 1340853003484 G3 box; other site 1340853003485 Switch II region; other site 1340853003486 G4 box; other site 1340853003487 G5 box; other site 1340853003488 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1340853003489 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1340853003490 Antibiotic Binding Site [chemical binding]; other site 1340853003491 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1340853003492 rRNA binding site [nucleotide binding]; other site 1340853003493 predicted 30S ribosome binding site; other site 1340853003494 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1340853003495 Protein of unknown function (DUF687); Region: DUF687; pfam05095 1340853003496 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1340853003497 active site 1340853003498 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1340853003499 triosephosphate isomerase; Provisional; Region: PRK14565 1340853003500 substrate binding site [chemical binding]; other site 1340853003501 dimer interface [polypeptide binding]; other site 1340853003502 catalytic triad [active] 1340853003503 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1340853003504 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1340853003505 generic binding surface II; other site 1340853003506 generic binding surface I; other site 1340853003507 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1340853003508 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1340853003509 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 1340853003510 TPP-binding site [chemical binding]; other site 1340853003511 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1340853003512 PYR/PP interface [polypeptide binding]; other site 1340853003513 dimer interface [polypeptide binding]; other site 1340853003514 TPP binding site [chemical binding]; other site 1340853003515 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1340853003516 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1340853003517 pyruvate kinase; Region: pyruv_kin; TIGR01064 1340853003518 domain interfaces; other site 1340853003519 active site 1340853003520 excinuclease ABC subunit A; Provisional; Region: PRK00635 1340853003521 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1340853003522 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1340853003523 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1340853003524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340853003525 Walker A/P-loop; other site 1340853003526 ATP binding site [chemical binding]; other site 1340853003527 Q-loop/lid; other site 1340853003528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340853003529 ABC transporter signature motif; other site 1340853003530 Walker B; other site 1340853003531 D-loop; other site 1340853003532 H-loop/switch region; other site 1340853003533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340853003534 Walker A/P-loop; other site 1340853003535 ATP binding site [chemical binding]; other site 1340853003536 Q-loop/lid; other site 1340853003537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340853003538 Q-loop/lid; other site 1340853003539 ABC transporter signature motif; other site 1340853003540 Walker B; other site 1340853003541 D-loop; other site 1340853003542 H-loop/switch region; other site 1340853003543 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 1340853003544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340853003545 Walker A motif; other site 1340853003546 ATP binding site [chemical binding]; other site 1340853003547 Walker B motif; other site 1340853003548 arginine finger; other site 1340853003549 hypothetical protein; Validated; Region: PRK00153 1340853003550 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 1340853003551 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1340853003552 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1340853003553 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1340853003554 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1340853003555 Competence protein; Region: Competence; pfam03772 1340853003556 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1340853003557 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1340853003558 tetramer interface [polypeptide binding]; other site 1340853003559 TPP-binding site [chemical binding]; other site 1340853003560 heterodimer interface [polypeptide binding]; other site 1340853003561 phosphorylation loop region [posttranslational modification] 1340853003562 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1340853003563 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1340853003564 alpha subunit interface [polypeptide binding]; other site 1340853003565 TPP binding site [chemical binding]; other site 1340853003566 heterodimer interface [polypeptide binding]; other site 1340853003567 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1340853003568 chaperone protein DnaJ; Provisional; Region: PRK14284 1340853003569 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1340853003570 HSP70 interaction site [polypeptide binding]; other site 1340853003571 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1340853003572 Zn binding sites [ion binding]; other site 1340853003573 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1340853003574 dimer interface [polypeptide binding]; other site 1340853003575 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1340853003576 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1340853003577 Glycoprotease family; Region: Peptidase_M22; pfam00814 1340853003578 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1340853003579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340853003580 Walker A motif; other site 1340853003581 ATP binding site [chemical binding]; other site 1340853003582 Walker B motif; other site 1340853003583 arginine finger; other site 1340853003584 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1340853003585 ribonuclease Z; Region: RNase_Z; TIGR02651 1340853003586 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1340853003587 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1340853003588 active site 1340853003589 Int/Topo IB signature motif; other site 1340853003590 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1340853003591 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1340853003592 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1340853003593 ABC transporter; Region: ABC_tran_2; pfam12848 1340853003594 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1340853003595 Maf-like protein; Region: Maf; pfam02545 1340853003596 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1340853003597 active site 1340853003598 dimer interface [polypeptide binding]; other site 1340853003599 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1340853003600 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1340853003601 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1340853003602 active site 1340853003603 catalytic residues [active] 1340853003604 metal binding site [ion binding]; metal-binding site 1340853003605 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1340853003606 dimethyladenosine transferase; Region: ksgA; TIGR00755 1340853003607 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1340853003608 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1340853003609 catalytic residues [active] 1340853003610 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1340853003611 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1340853003612 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1340853003613 inhibitor site; inhibition site 1340853003614 active site 1340853003615 dimer interface [polypeptide binding]; other site 1340853003616 catalytic residue [active] 1340853003617 aspartate kinase; Provisional; Region: PRK05925 1340853003618 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 1340853003619 putative catalytic residues [active] 1340853003620 nucleotide binding site [chemical binding]; other site 1340853003621 aspartate binding site [chemical binding]; other site 1340853003622 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 1340853003623 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1340853003624 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1340853003625 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1340853003626 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1340853003627 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 1340853003628 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1340853003629 hinge; other site 1340853003630 active site 1340853003631 shikimate kinase; Provisional; Region: PRK00625 1340853003632 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1340853003633 ADP binding site [chemical binding]; other site 1340853003634 magnesium binding site [ion binding]; other site 1340853003635 putative shikimate binding site; other site 1340853003636 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1340853003637 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1340853003638 Tetramer interface [polypeptide binding]; other site 1340853003639 active site 1340853003640 FMN-binding site [chemical binding]; other site 1340853003641 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1340853003642 active site 1340853003643 dimer interface [polypeptide binding]; other site 1340853003644 metal binding site [ion binding]; metal-binding site 1340853003645 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 1340853003646 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1340853003647 active site 1340853003648 catalytic residue [active] 1340853003649 dimer interface [polypeptide binding]; other site 1340853003650 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1340853003651 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1340853003652 shikimate binding site; other site 1340853003653 NAD(P) binding site [chemical binding]; other site 1340853003654 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 1340853003655 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 1340853003656 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1340853003657 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1340853003658 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1340853003659 malate dehydrogenase; Provisional; Region: PRK05442 1340853003660 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1340853003661 NAD(P) binding site [chemical binding]; other site 1340853003662 dimer interface [polypeptide binding]; other site 1340853003663 malate binding site [chemical binding]; other site 1340853003664 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 1340853003665 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1340853003666 active site 1340853003667 dimer interface [polypeptide binding]; other site 1340853003668 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1340853003669 dimer interface [polypeptide binding]; other site 1340853003670 active site 1340853003671 GTPases [General function prediction only]; Region: HflX; COG2262 1340853003672 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1340853003673 HflX GTPase family; Region: HflX; cd01878 1340853003674 G1 box; other site 1340853003675 GTP/Mg2+ binding site [chemical binding]; other site 1340853003676 Switch I region; other site 1340853003677 G2 box; other site 1340853003678 G3 box; other site 1340853003679 Switch II region; other site 1340853003680 G4 box; other site 1340853003681 G5 box; other site 1340853003682 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1340853003683 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1340853003684 substrate binding pocket [chemical binding]; other site 1340853003685 membrane-bound complex binding site; other site 1340853003686 hinge residues; other site 1340853003687 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 1340853003688 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1340853003689 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1340853003690 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1340853003691 nucleotide binding site/active site [active] 1340853003692 Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286 1340853003693 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1340853003694 hypothetical protein; Validated; Region: PRK00647 1340853003695 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 1340853003696 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 1340853003697 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1340853003698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1340853003699 homodimer interface [polypeptide binding]; other site 1340853003700 catalytic residue [active] 1340853003701 ABC transporter substrate binding protein; Region: ABC_sub_bind; pfam04392 1340853003702 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1340853003703 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1340853003704 dimer interface [polypeptide binding]; other site 1340853003705 motif 1; other site 1340853003706 active site 1340853003707 motif 2; other site 1340853003708 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1340853003709 putative deacylase active site [active] 1340853003710 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1340853003711 active site 1340853003712 motif 3; other site 1340853003713 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1340853003714 anticodon binding site; other site 1340853003715 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 1340853003716 GrpE; Region: GrpE; pfam01025 1340853003717 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1340853003718 dimer interface [polypeptide binding]; other site 1340853003719 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1340853003720 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1340853003721 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1340853003722 nucleotide binding site [chemical binding]; other site 1340853003723 NEF interaction site [polypeptide binding]; other site 1340853003724 SBD interface [polypeptide binding]; other site 1340853003725 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 1340853003726 Exoribonuclease R [Transcription]; Region: VacB; COG0557 1340853003727 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1340853003728 RNB domain; Region: RNB; pfam00773 1340853003729 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1340853003730 Putative zinc ribbon domain; Region: DUF164; pfam02591 1340853003731 KpsF/GutQ family protein; Region: kpsF; TIGR00393 1340853003732 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1340853003733 putative active site [active] 1340853003734 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1340853003735 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1340853003736 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1340853003737 E3 interaction surface; other site 1340853003738 lipoyl attachment site [posttranslational modification]; other site 1340853003739 e3 binding domain; Region: E3_binding; pfam02817 1340853003740 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1340853003741 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1340853003742 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1340853003743 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1340853003744 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1340853003745 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1340853003746 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1340853003747 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1340853003748 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1340853003749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340853003750 S-adenosylmethionine binding site [chemical binding]; other site 1340853003751 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1340853003752 Lumazine binding domain; Region: Lum_binding; pfam00677 1340853003753 Lumazine binding domain; Region: Lum_binding; pfam00677 1340853003754 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 1340853003755 ATP cone domain; Region: ATP-cone; pfam03477 1340853003756 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1340853003757 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 1340853003758 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1340853003759 amino acid carrier protein; Region: agcS; TIGR00835 1340853003760 poly(A) polymerase; Region: pcnB; TIGR01942 1340853003761 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1340853003762 active site 1340853003763 NTP binding site [chemical binding]; other site 1340853003764 metal binding triad [ion binding]; metal-binding site 1340853003765 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1340853003766 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 1340853003767 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 1340853003768 Predicted membrane protein [Function unknown]; Region: COG3952 1340853003769 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1340853003770 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 1340853003771 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 1340853003772 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1340853003773 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 1340853003774 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1340853003775 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 1340853003776 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 1340853003777 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1340853003778 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1340853003779 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1340853003780 intersubunit interface [polypeptide binding]; other site 1340853003781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1340853003782 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1340853003783 Walker A/P-loop; other site 1340853003784 ATP binding site [chemical binding]; other site 1340853003785 Q-loop/lid; other site 1340853003786 ABC transporter signature motif; other site 1340853003787 Walker B; other site 1340853003788 D-loop; other site 1340853003789 H-loop/switch region; other site 1340853003790 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1340853003791 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1340853003792 ABC-ATPase subunit interface; other site 1340853003793 dimer interface [polypeptide binding]; other site 1340853003794 putative PBP binding regions; other site 1340853003795 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1340853003796 GTP1/OBG; Region: GTP1_OBG; pfam01018 1340853003797 Obg GTPase; Region: Obg; cd01898 1340853003798 G1 box; other site 1340853003799 GTP/Mg2+ binding site [chemical binding]; other site 1340853003800 Switch I region; other site 1340853003801 G2 box; other site 1340853003802 G3 box; other site 1340853003803 Switch II region; other site 1340853003804 G4 box; other site 1340853003805 G5 box; other site 1340853003806 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1340853003807 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 1340853003808 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1340853003809 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 1340853003810 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 1340853003811 FOG: CBS domain [General function prediction only]; Region: COG0517 1340853003812 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1340853003813 Transporter associated domain; Region: CorC_HlyC; smart01091 1340853003814 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1340853003815 anti sigma factor interaction site; other site 1340853003816 regulatory phosphorylation site [posttranslational modification]; other site 1340853003817 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 1340853003818 hypothetical protein; Provisional; Region: PRK05926 1340853003819 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1340853003820 FeS/SAM binding site; other site 1340853003821 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 1340853003822 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1340853003823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340853003824 S-adenosylmethionine binding site [chemical binding]; other site 1340853003825 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1340853003826 diaminopimelate epimerase; Region: DapF; TIGR00652 1340853003827 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1340853003828 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1340853003829 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1340853003830 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1340853003831 active site 1340853003832 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1340853003833 homotrimer interaction site [polypeptide binding]; other site 1340853003834 zinc binding site [ion binding]; other site 1340853003835 CDP-binding sites; other site 1340853003836 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1340853003837 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1340853003838 FAD binding pocket [chemical binding]; other site 1340853003839 conserved FAD binding motif [chemical binding]; other site 1340853003840 phosphate binding motif [ion binding]; other site 1340853003841 beta-alpha-beta structure motif; other site 1340853003842 NAD binding pocket [chemical binding]; other site 1340853003843 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1340853003844 elongation factor G; Reviewed; Region: PRK12739 1340853003845 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1340853003846 G1 box; other site 1340853003847 putative GEF interaction site [polypeptide binding]; other site 1340853003848 GTP/Mg2+ binding site [chemical binding]; other site 1340853003849 Switch I region; other site 1340853003850 G2 box; other site 1340853003851 G3 box; other site 1340853003852 Switch II region; other site 1340853003853 G4 box; other site 1340853003854 G5 box; other site 1340853003855 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1340853003856 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1340853003857 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1340853003858 30S ribosomal protein S7; Validated; Region: PRK05302 1340853003859 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1340853003860 S17 interaction site [polypeptide binding]; other site 1340853003861 S8 interaction site; other site 1340853003862 16S rRNA interaction site [nucleotide binding]; other site 1340853003863 streptomycin interaction site [chemical binding]; other site 1340853003864 23S rRNA interaction site [nucleotide binding]; other site 1340853003865 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1340853003866 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1340853003867 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1340853003868 protein binding site [polypeptide binding]; other site 1340853003869 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1340853003870 Catalytic dyad [active] 1340853003871 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 1340853003872 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 1340853003873 Domain of unknown function DUF11; Region: DUF11; pfam01345 1340853003874 Domain of unknown function DUF11; Region: DUF11; pfam01345 1340853003875 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 1340853003876 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1340853003877 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1340853003878 HIGH motif; other site 1340853003879 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1340853003880 active site 1340853003881 KMSKS motif; other site 1340853003882 Helix-turn-helix domain; Region: HTH_17; pfam12728 1340853003883 Helix-turn-helix domain; Region: HTH_17; pfam12728 1340853003884 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1340853003885 DHH family; Region: DHH; pfam01368 1340853003886 DHHA1 domain; Region: DHHA1; pfam02272 1340853003887 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 1340853003888 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1340853003889 Protein export membrane protein; Region: SecD_SecF; pfam02355 1340853003890 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 1340853003891 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1340853003892 catalytic residue [active] 1340853003893 putative FPP diphosphate binding site; other site 1340853003894 putative FPP binding hydrophobic cleft; other site 1340853003895 dimer interface [polypeptide binding]; other site 1340853003896 putative IPP diphosphate binding site; other site 1340853003897 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1340853003898 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1340853003899 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 1340853003900 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1340853003901 CMP-binding site; other site 1340853003902 The sites determining sugar specificity; other site 1340853003903 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1340853003904 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1340853003905 putative acyl-acceptor binding pocket; other site 1340853003906 arginine-tRNA ligase; Region: PLN02286 1340853003907 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1340853003908 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1340853003909 active site 1340853003910 HIGH motif; other site 1340853003911 KMSK motif region; other site 1340853003912 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1340853003913 tRNA binding surface [nucleotide binding]; other site 1340853003914 anticodon binding site; other site 1340853003915 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1340853003916 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1340853003917 hinge; other site 1340853003918 active site 1340853003919 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 1340853003920 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 1340853003921 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 1340853003922 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 1340853003923 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1340853003924 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1340853003925 Coenzyme A binding pocket [chemical binding]; other site 1340853003926 SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531 1340853003927 SWI complex, BAF60b domains; Region: SWIB; smart00151 1340853003928 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1340853003929 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1340853003930 putative active site [active] 1340853003931 putative metal binding site [ion binding]; other site 1340853003932 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1340853003933 substrate binding site; other site 1340853003934 dimer interface; other site 1340853003935 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1340853003936 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1340853003937 dimerization interface 3.5A [polypeptide binding]; other site 1340853003938 active site 1340853003939 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1340853003940 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1340853003941 active site 1340853003942 motif I; other site 1340853003943 motif II; other site 1340853003944 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1340853003945 PAS domain; Region: PAS; smart00091 1340853003946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1340853003947 dimer interface [polypeptide binding]; other site 1340853003948 phosphorylation site [posttranslational modification] 1340853003949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1340853003950 ATP binding site [chemical binding]; other site 1340853003951 Mg2+ binding site [ion binding]; other site 1340853003952 G-X-G motif; other site 1340853003953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1340853003954 Response regulator receiver domain; Region: Response_reg; pfam00072 1340853003955 active site 1340853003956 phosphorylation site [posttranslational modification] 1340853003957 intermolecular recognition site; other site 1340853003958 dimerization interface [polypeptide binding]; other site 1340853003959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340853003960 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1340853003961 Walker A motif; other site 1340853003962 ATP binding site [chemical binding]; other site 1340853003963 Walker B motif; other site 1340853003964 arginine finger; other site 1340853003965 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 1340853003966 Recombination protein O N terminal; Region: RecO_N; pfam11967 1340853003967 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 1340853003968 Recombination protein O C terminal; Region: RecO_C; pfam02565 1340853003969 Uncharacterized conserved protein [Function unknown]; Region: COG1723 1340853003970 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1340853003971 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1340853003972 putative tRNA-binding site [nucleotide binding]; other site 1340853003973 B3/4 domain; Region: B3_4; pfam03483 1340853003974 tRNA synthetase B5 domain; Region: B5; smart00874 1340853003975 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1340853003976 dimer interface [polypeptide binding]; other site 1340853003977 motif 1; other site 1340853003978 motif 3; other site 1340853003979 motif 2; other site 1340853003980 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1340853003981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1340853003982 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1340853003983 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1340853003984 DNA binding site [nucleotide binding] 1340853003985 active site 1340853003986 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1340853003987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1340853003988 dimer interface [polypeptide binding]; other site 1340853003989 conserved gate region; other site 1340853003990 putative PBP binding loops; other site 1340853003991 ABC-ATPase subunit interface; other site 1340853003992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1340853003993 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1340853003994 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1340853003995 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1340853003996 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1340853003997 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1340853003998 putative active site [active] 1340853003999 putative metal binding site [ion binding]; other site 1340853004000 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1340853004001 binding surface 1340853004002 TPR motif; other site 1340853004003 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1340853004004 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 1340853004005 C-terminal domain interface [polypeptide binding]; other site 1340853004006 active site 1340853004007 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1340853004008 active site 1340853004009 N-terminal domain interface [polypeptide binding]; other site 1340853004010 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 1340853004011 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1340853004012 substrate binding pocket [chemical binding]; other site 1340853004013 membrane-bound complex binding site; other site 1340853004014 hinge residues; other site 1340853004015 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1340853004016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340853004017 S-adenosylmethionine binding site [chemical binding]; other site 1340853004018 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 1340853004019 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1340853004020 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 1340853004021 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1340853004022 ligand binding site; other site 1340853004023 oligomer interface; other site 1340853004024 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1340853004025 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1340853004026 N-terminal domain interface [polypeptide binding]; other site 1340853004027 sulfate 1 binding site; other site 1340853004028 transcription termination factor Rho; Region: rho; TIGR00767 1340853004029 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1340853004030 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1340853004031 RNA binding site [nucleotide binding]; other site 1340853004032 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1340853004033 multimer interface [polypeptide binding]; other site 1340853004034 Walker A motif; other site 1340853004035 ATP binding site [chemical binding]; other site 1340853004036 Walker B motif; other site 1340853004037 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1340853004038 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1340853004039 CoA-binding site [chemical binding]; other site 1340853004040 ATP-binding [chemical binding]; other site 1340853004041 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1340853004042 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1340853004043 tandem repeat interface [polypeptide binding]; other site 1340853004044 oligomer interface [polypeptide binding]; other site 1340853004045 active site residues [active] 1340853004046 TLC ATP/ADP transporter; Region: TLC; pfam03219 1340853004047 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1340853004048 replicative DNA helicase; Provisional; Region: PRK06321 1340853004049 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1340853004050 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1340853004051 Walker A motif; other site 1340853004052 ATP binding site [chemical binding]; other site 1340853004053 Walker B motif; other site 1340853004054 DNA binding loops [nucleotide binding] 1340853004055 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1340853004056 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1340853004057 active site 1340853004058 multimer interface [polypeptide binding]; other site 1340853004059 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1340853004060 RuvA N terminal domain; Region: RuvA_N; pfam01330 1340853004061 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1340853004062 active site 1340853004063 putative DNA-binding cleft [nucleotide binding]; other site 1340853004064 dimer interface [polypeptide binding]; other site 1340853004065 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1340853004066 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1340853004067 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1340853004068 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1340853004069 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 1340853004070 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 1340853004071 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1340853004072 alphaNTD - beta interaction site [polypeptide binding]; other site 1340853004073 alphaNTD homodimer interface [polypeptide binding]; other site 1340853004074 alphaNTD - beta' interaction site [polypeptide binding]; other site 1340853004075 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1340853004076 30S ribosomal protein S11; Validated; Region: PRK05309 1340853004077 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1340853004078 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1340853004079 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1340853004080 SecY translocase; Region: SecY; pfam00344 1340853004081 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 1340853004082 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 1340853004083 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1340853004084 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1340853004085 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1340853004086 5S rRNA interface [nucleotide binding]; other site 1340853004087 23S rRNA interface [nucleotide binding]; other site 1340853004088 L5 interface [polypeptide binding]; other site 1340853004089 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1340853004090 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1340853004091 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1340853004092 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1340853004093 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1340853004094 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1340853004095 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1340853004096 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 1340853004097 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1340853004098 RNA binding site [nucleotide binding]; other site 1340853004099 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1340853004100 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1340853004101 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1340853004102 23S rRNA interface [nucleotide binding]; other site 1340853004103 putative translocon interaction site; other site 1340853004104 signal recognition particle (SRP54) interaction site; other site 1340853004105 L23 interface [polypeptide binding]; other site 1340853004106 trigger factor interaction site; other site 1340853004107 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1340853004108 23S rRNA interface [nucleotide binding]; other site 1340853004109 5S rRNA interface [nucleotide binding]; other site 1340853004110 putative antibiotic binding site [chemical binding]; other site 1340853004111 L25 interface [polypeptide binding]; other site 1340853004112 L27 interface [polypeptide binding]; other site 1340853004113 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 1340853004114 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1340853004115 G-X-X-G motif; other site 1340853004116 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1340853004117 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1340853004118 putative translocon binding site; other site 1340853004119 protein-rRNA interface [nucleotide binding]; other site 1340853004120 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1340853004121 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1340853004122 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1340853004123 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1340853004124 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 1340853004125 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1340853004126 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1340853004127 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1340853004128 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1340853004129 putative active site [active] 1340853004130 substrate binding site [chemical binding]; other site 1340853004131 putative cosubstrate binding site; other site 1340853004132 catalytic site [active] 1340853004133 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1340853004134 substrate binding site [chemical binding]; other site 1340853004135 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 1340853004136 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1340853004137 active site 1340853004138 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1340853004139 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 1340853004140 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1340853004141 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1340853004142 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1340853004143 putative active site [active] 1340853004144 catalytic triad [active] 1340853004145 putative dimer interface [polypeptide binding]; other site 1340853004146 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1340853004147 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 1340853004148 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1340853004149 active site 1340853004150 catalytic site [active] 1340853004151 substrate binding site [chemical binding]; other site 1340853004152 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 1340853004153 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1340853004154 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 1340853004155 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1340853004156 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1340853004157 catalytic residues [active] 1340853004158 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1340853004159 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1340853004160 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1340853004161 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1340853004162 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1340853004163 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1340853004164 dimer interface [polypeptide binding]; other site 1340853004165 anticodon binding site; other site 1340853004166 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1340853004167 homodimer interface [polypeptide binding]; other site 1340853004168 motif 1; other site 1340853004169 active site 1340853004170 motif 2; other site 1340853004171 GAD domain; Region: GAD; pfam02938 1340853004172 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1340853004173 active site 1340853004174 motif 3; other site 1340853004175 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1340853004176 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1340853004177 dimer interface [polypeptide binding]; other site 1340853004178 motif 1; other site 1340853004179 active site 1340853004180 motif 2; other site 1340853004181 motif 3; other site 1340853004182 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1340853004183 anticodon binding site; other site 1340853004184 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1340853004185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340853004186 putative substrate translocation pore; other site 1340853004187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340853004188 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1340853004189 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1340853004190 active site 1340853004191 PHP Thumb interface [polypeptide binding]; other site 1340853004192 metal binding site [ion binding]; metal-binding site 1340853004193 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1340853004194 generic binding surface I; other site 1340853004195 generic binding surface II; other site 1340853004196 TPR repeat; Region: TPR_11; pfam13414 1340853004197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1340853004198 binding surface 1340853004199 TPR motif; other site 1340853004200 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 1340853004201 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1340853004202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1340853004203 Mg2+ binding site [ion binding]; other site 1340853004204 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1340853004205 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1340853004206 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1340853004207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340853004208 S-adenosylmethionine binding site [chemical binding]; other site 1340853004209 branched-chain amino acid uptake carrier; Region: livcs; TIGR00796 1340853004210 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1340853004211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1340853004212 ATP binding site [chemical binding]; other site 1340853004213 putative Mg++ binding site [ion binding]; other site 1340853004214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1340853004215 ATP-binding site [chemical binding]; other site 1340853004216 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 1340853004217 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1340853004218 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1340853004219 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1340853004220 lipoate synthase; Region: lipA; TIGR00510 1340853004221 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1340853004222 FeS/SAM binding site; other site 1340853004223 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 1340853004224 type III secretion system protein; Validated; Region: PRK06328 1340853004225 Flagellar assembly protein FliH; Region: FliH; pfam02108 1340853004226 type III secretion system protein; Reviewed; Region: PRK09617 1340853004227 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 1340853004228 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 1340853004229 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 1340853004230 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1340853004231 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1340853004232 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1340853004233 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1340853004234 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1340853004235 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1340853004236 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1340853004237 Walker A motif; other site 1340853004238 ATP binding site [chemical binding]; other site 1340853004239 Walker B motif; other site 1340853004240 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 1340853004241 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1340853004242 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1340853004243 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1340853004244 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1340853004245 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1340853004246 active site 1340853004247 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 1340853004248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1340853004249 ATP binding site [chemical binding]; other site 1340853004250 Mg2+ binding site [ion binding]; other site 1340853004251 G-X-G motif; other site 1340853004252 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1340853004253 ATP binding site [chemical binding]; other site 1340853004254 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1340853004255 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 1340853004256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1340853004257 binding surface 1340853004258 TPR motif; other site 1340853004259 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1340853004260 EamA-like transporter family; Region: EamA; pfam00892 1340853004261 EamA-like transporter family; Region: EamA; pfam00892 1340853004262 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1340853004263 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cd01616 1340853004264 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1340853004265 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1340853004266 active site 1340853004267 dimer interface [polypeptide binding]; other site 1340853004268 motif 1; other site 1340853004269 motif 2; other site 1340853004270 motif 3; other site 1340853004271 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1340853004272 anticodon binding site; other site 1340853004273 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1340853004274 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1340853004275 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 1340853004276 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1340853004277 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1340853004278 active site 1340853004279 HIGH motif; other site 1340853004280 dimer interface [polypeptide binding]; other site 1340853004281 KMSKS motif; other site 1340853004282 excinuclease ABC subunit B; Provisional; Region: PRK05298 1340853004283 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1340853004284 ATP binding site [chemical binding]; other site 1340853004285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1340853004286 nucleotide binding region [chemical binding]; other site 1340853004287 ATP-binding site [chemical binding]; other site 1340853004288 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1340853004289 enolase; Provisional; Region: eno; PRK00077 1340853004290 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1340853004291 dimer interface [polypeptide binding]; other site 1340853004292 metal binding site [ion binding]; metal-binding site 1340853004293 substrate binding pocket [chemical binding]; other site 1340853004294 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1340853004295 HAMP domain; Region: HAMP; pfam00672 1340853004296 dimerization interface [polypeptide binding]; other site 1340853004297 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1340853004298 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1340853004299 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1340853004300 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1340853004301 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1340853004302 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 1340853004303 Iron-sulfur protein interface; other site 1340853004304 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 1340853004305 proximal heme binding site [chemical binding]; other site 1340853004306 Iron-sulfur protein interface; other site 1340853004307 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1340853004308 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1340853004309 active site 1340853004310 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 1340853004311 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1340853004312 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1340853004313 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1340853004314 DsbD alpha interface [polypeptide binding]; other site 1340853004315 catalytic residues [active] 1340853004316 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1340853004317 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1340853004318 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1340853004319 translocation protein TolB; Provisional; Region: tolB; PRK01029 1340853004320 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1340853004321 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1340853004322 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1340853004323 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1340853004324 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1340853004325 ligand binding site [chemical binding]; other site 1340853004326 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1340853004327 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1340853004328 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1340853004329 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1340853004330 dimer interface [polypeptide binding]; other site 1340853004331 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1340853004332 catalytic triad [active] 1340853004333 peroxidatic and resolving cysteines [active] 1340853004334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 1340853004335 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1340853004336 ligand binding site [chemical binding]; other site 1340853004337 active site 1340853004338 UGI interface [polypeptide binding]; other site 1340853004339 catalytic site [active] 1340853004340 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1340853004341 Part of AAA domain; Region: AAA_19; pfam13245 1340853004342 Family description; Region: UvrD_C_2; pfam13538 1340853004343 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 1340853004344 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1340853004345 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1340853004346 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1340853004347 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 1340853004348 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 1340853004349 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1340853004350 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1340853004351 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1340853004352 folate binding site [chemical binding]; other site 1340853004353 NADP+ binding site [chemical binding]; other site 1340853004354 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1340853004355 catalytic center binding site [active] 1340853004356 ATP binding site [chemical binding]; other site 1340853004357 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1340853004358 dihydropteroate synthase; Region: DHPS; TIGR01496 1340853004359 substrate binding pocket [chemical binding]; other site 1340853004360 dimer interface [polypeptide binding]; other site 1340853004361 inhibitor binding site; inhibition site 1340853004362 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1340853004363 homooctamer interface [polypeptide binding]; other site 1340853004364 active site 1340853004365 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1340853004366 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1340853004367 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1340853004368 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1340853004369 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1340853004370 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1340853004371 DNA binding residues [nucleotide binding] 1340853004372 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 1340853004373 Effector from type III secretion system; Region: Effector_1; pfam04518 1340853004374 Effector from type III secretion system; Region: Effector_1; pfam04518 1340853004375 Effector from type III secretion system; Region: Effector_1; pfam04518 1340853004376 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1340853004377 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1340853004378 MviN-like protein; Region: MVIN; pfam03023 1340853004379 endonuclease IV; Provisional; Region: PRK01060 1340853004380 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1340853004381 AP (apurinic/apyrimidinic) site pocket; other site 1340853004382 DNA interaction; other site 1340853004383 Metal-binding active site; metal-binding site 1340853004384 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1340853004385 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 1340853004386 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1340853004387 RNA binding surface [nucleotide binding]; other site 1340853004388 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1340853004389 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1340853004390 active site residue [active] 1340853004391 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1340853004392 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1340853004393 substrate binding pocket [chemical binding]; other site 1340853004394 chain length determination region; other site 1340853004395 substrate-Mg2+ binding site; other site 1340853004396 catalytic residues [active] 1340853004397 aspartate-rich region 1; other site 1340853004398 active site lid residues [active] 1340853004399 aspartate-rich region 2; other site 1340853004400 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 1340853004401 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1340853004402 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1340853004403 DNA binding site [nucleotide binding] 1340853004404 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 1340853004405 Thymidylate synthase complementing protein; Region: Thy1; cl03630 1340853004406 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1340853004407 dimer interface [polypeptide binding]; other site 1340853004408 active site 1340853004409 aspartate-rich active site metal binding site; other site 1340853004410 allosteric magnesium binding site [ion binding]; other site 1340853004411 Schiff base residues; other site 1340853004412 NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit; Region: nqrA; TIGR01936 1340853004413 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 1340853004414 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 1340853004415 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1340853004416 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1340853004417 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1340853004418 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1340853004419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1340853004420 homodimer interface [polypeptide binding]; other site 1340853004421 catalytic residue [active] 1340853004422 rod shape-determining protein MreC; Provisional; Region: PRK14872 1340853004423 rod shape-determining protein MreC; Region: MreC; pfam04085 1340853004424 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1340853004425 Part of AAA domain; Region: AAA_19; pfam13245 1340853004426 Family description; Region: UvrD_C_2; pfam13538 1340853004427 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 1340853004428 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1340853004429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1340853004430 putative substrate translocation pore; other site 1340853004431 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 1340853004432 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1340853004433 active site 1340853004434 interdomain interaction site; other site 1340853004435 putative metal-binding site [ion binding]; other site 1340853004436 nucleotide binding site [chemical binding]; other site 1340853004437 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1340853004438 domain I; other site 1340853004439 DNA binding groove [nucleotide binding] 1340853004440 phosphate binding site [ion binding]; other site 1340853004441 domain II; other site 1340853004442 domain III; other site 1340853004443 nucleotide binding site [chemical binding]; other site 1340853004444 catalytic site [active] 1340853004445 domain IV; other site 1340853004446 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1340853004447 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1340853004448 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1340853004449 SWI complex, BAF60b domains; Region: SWIB; smart00151 1340853004450 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1340853004451 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1340853004452 FMN binding site [chemical binding]; other site 1340853004453 active site 1340853004454 catalytic residues [active] 1340853004455 substrate binding site [chemical binding]; other site 1340853004456 Predicted integral membrane protein [Function unknown]; Region: COG0762 1340853004457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1340853004458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1340853004459 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1340853004460 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1340853004461 recombinase A; Provisional; Region: recA; PRK09354 1340853004462 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1340853004463 hexamer interface [polypeptide binding]; other site 1340853004464 Walker A motif; other site 1340853004465 ATP binding site [chemical binding]; other site 1340853004466 Walker B motif; other site 1340853004467 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 1340853004468 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1340853004469 AAA domain; Region: AAA_30; pfam13604 1340853004470 Family description; Region: UvrD_C_2; pfam13538 1340853004471 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1340853004472 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1340853004473 Walker A/P-loop; other site 1340853004474 ATP binding site [chemical binding]; other site 1340853004475 Q-loop/lid; other site 1340853004476 ABC transporter signature motif; other site 1340853004477 Walker B; other site 1340853004478 D-loop; other site 1340853004479 H-loop/switch region; other site 1340853004480 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 1340853004481 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 1340853004482 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1340853004483 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1340853004484 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1340853004485 RNA binding surface [nucleotide binding]; other site 1340853004486 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1340853004487 active site 1340853004488 hypothetical protein; Provisional; Region: PRK01064 1340853004489 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1340853004490 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 1340853004491 DNA Topoisomerase IV; Region: TOP4c; smart00434 1340853004492 CAP-like domain; other site 1340853004493 active site 1340853004494 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1340853004495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1340853004496 ATP binding site [chemical binding]; other site 1340853004497 Mg2+ binding site [ion binding]; other site 1340853004498 G-X-G motif; other site 1340853004499 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 1340853004500 ATP binding site [chemical binding]; other site 1340853004501 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 1340853004502 active site 1340853004503 putative metal-binding site [ion binding]; other site 1340853004504 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1340853004505 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 1340853004506 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 1340853004507 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 1340853004508 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1340853004509 phosphopeptide binding site; other site 1340853004510 MARCKS family; Region: MARCKS; pfam02063 1340853004511 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1340853004512 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1340853004513 phosphopeptide binding site; other site 1340853004514 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1340853004515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1340853004516 binding surface 1340853004517 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1340853004518 TPR motif; other site 1340853004519 type III secretion system ATPase; Provisional; Region: PRK06315 1340853004520 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1340853004521 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1340853004522 Walker A motif/ATP binding site; other site 1340853004523 Walker B motif; other site 1340853004524 type III secretion system protein; Validated; Region: PRK05933 1340853004525 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1340853004526 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1340853004527 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1340853004528 active site 1340853004529 ATP binding site [chemical binding]; other site 1340853004530 substrate binding site [chemical binding]; other site 1340853004531 activation loop (A-loop); other site 1340853004532 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 1340853004533 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1340853004534 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1340853004535 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1340853004536 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 1340853004537 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 1340853004538 ADP binding site [chemical binding]; other site 1340853004539 phosphagen binding site; other site 1340853004540 substrate specificity loop; other site 1340853004541 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1340853004542 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1340853004543 hinge region; other site 1340853004544 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1340853004545 putative nucleotide binding site [chemical binding]; other site 1340853004546 uridine monophosphate binding site [chemical binding]; other site 1340853004547 homohexameric interface [polypeptide binding]; other site 1340853004548 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 1340853004549 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 1340853004550 Elongation factor TS; Region: EF_TS; pfam00889 1340853004551 Elongation factor TS; Region: EF_TS; pfam00889 1340853004552 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1340853004553 rRNA interaction site [nucleotide binding]; other site 1340853004554 S8 interaction site; other site 1340853004555 putative laminin-1 binding site; other site 1340853004556 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 1340853004557 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1340853004558 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1340853004559 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1340853004560 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1340853004561 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1340853004562 TPR motif; other site 1340853004563 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1340853004564 binding surface 1340853004565 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1340853004566 binding surface 1340853004567 TPR motif; other site 1340853004568 TPR repeat; Region: TPR_11; pfam13414 1340853004569 TPR repeat; Region: TPR_11; pfam13414 1340853004570 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1340853004571 binding surface 1340853004572 TPR motif; other site 1340853004573 TPR repeat; Region: TPR_11; pfam13414 1340853004574 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1340853004575 putative ABC transporter; Region: ycf24; CHL00085 1340853004576 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1340853004577 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1340853004578 Walker A/P-loop; other site 1340853004579 ATP binding site [chemical binding]; other site 1340853004580 Q-loop/lid; other site 1340853004581 ABC transporter signature motif; other site 1340853004582 Walker B; other site 1340853004583 D-loop; other site 1340853004584 H-loop/switch region; other site 1340853004585 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1340853004586 FeS assembly protein SufD; Region: sufD; TIGR01981 1340853004587 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1340853004588 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1340853004589 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1340853004590 catalytic residue [active] 1340853004591 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1340853004592 ParB-like nuclease domain; Region: ParBc; pfam02195 1340853004593 KorB domain; Region: KorB; pfam08535 1340853004594 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1340853004595 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1340853004596 Walker A/P-loop; other site 1340853004597 ATP binding site [chemical binding]; other site 1340853004598 Q-loop/lid; other site 1340853004599 ABC transporter signature motif; other site 1340853004600 Walker B; other site 1340853004601 D-loop; other site 1340853004602 H-loop/switch region; other site 1340853004603 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1340853004604 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1340853004605 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1340853004606 Walker A/P-loop; other site 1340853004607 ATP binding site [chemical binding]; other site 1340853004608 Q-loop/lid; other site 1340853004609 ABC transporter signature motif; other site 1340853004610 Walker B; other site 1340853004611 D-loop; other site 1340853004612 H-loop/switch region; other site 1340853004613 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1340853004614 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 1340853004615 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1340853004616 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1340853004617 Phosphoglycerate kinase; Region: PGK; pfam00162 1340853004618 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1340853004619 substrate binding site [chemical binding]; other site 1340853004620 hinge regions; other site 1340853004621 ADP binding site [chemical binding]; other site 1340853004622 catalytic site [active] 1340853004623 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1340853004624 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1340853004625 minor groove reading motif; other site 1340853004626 helix-hairpin-helix signature motif; other site 1340853004627 substrate binding pocket [chemical binding]; other site 1340853004628 active site 1340853004629 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 1340853004630 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1340853004631 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1340853004632 G1 box; other site 1340853004633 GTP/Mg2+ binding site [chemical binding]; other site 1340853004634 Switch I region; other site 1340853004635 G2 box; other site 1340853004636 Switch II region; other site 1340853004637 G3 box; other site 1340853004638 G4 box; other site 1340853004639 G5 box; other site 1340853004640 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1340853004641 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 1340853004642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1340853004643 binding surface 1340853004644 TPR motif; other site 1340853004645 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 1340853004646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1340853004647 ATP binding site [chemical binding]; other site 1340853004648 putative Mg++ binding site [ion binding]; other site 1340853004649 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1340853004650 Predicted GTPases [General function prediction only]; Region: COG1160 1340853004651 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1340853004652 G1 box; other site 1340853004653 GTP/Mg2+ binding site [chemical binding]; other site 1340853004654 Switch I region; other site 1340853004655 G2 box; other site 1340853004656 Switch II region; other site 1340853004657 G3 box; other site 1340853004658 G4 box; other site 1340853004659 G5 box; other site 1340853004660 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1340853004661 G1 box; other site 1340853004662 GTP/Mg2+ binding site [chemical binding]; other site 1340853004663 Switch I region; other site 1340853004664 G2 box; other site 1340853004665 G3 box; other site 1340853004666 Switch II region; other site 1340853004667 G4 box; other site 1340853004668 G5 box; other site 1340853004669 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1340853004670 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1340853004671 active site 1340853004672 NTP binding site [chemical binding]; other site 1340853004673 metal binding triad [ion binding]; metal-binding site 1340853004674 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1340853004675 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1340853004676 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 1340853004677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340853004678 Walker A motif; other site 1340853004679 ATP binding site [chemical binding]; other site 1340853004680 Walker B motif; other site 1340853004681 arginine finger; other site 1340853004682 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1340853004683 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1340853004684 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1340853004685 oligomer interface [polypeptide binding]; other site 1340853004686 active site residues [active] 1340853004687 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 1340853004688 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1340853004689 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1340853004690 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1340853004691 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1340853004692 ATP binding site [chemical binding]; other site 1340853004693 putative Mg++ binding site [ion binding]; other site 1340853004694 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1340853004695 nucleotide binding region [chemical binding]; other site 1340853004696 ATP-binding site [chemical binding]; other site 1340853004697 rod shape-determining protein MreB; Provisional; Region: PRK13927 1340853004698 MreB and similar proteins; Region: MreB_like; cd10225 1340853004699 nucleotide binding site [chemical binding]; other site 1340853004700 Mg binding site [ion binding]; other site 1340853004701 putative protofilament interaction site [polypeptide binding]; other site 1340853004702 RodZ interaction site [polypeptide binding]; other site 1340853004703 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1340853004704 active site 1340853004705 substrate-binding site [chemical binding]; other site 1340853004706 metal-binding site [ion binding] 1340853004707 GTP binding site [chemical binding]; other site 1340853004708 Effector from type III secretion system; Region: Effector_1; pfam04518 1340853004709 Effector from type III secretion system; Region: Effector_1; pfam04518 1340853004710 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 1340853004711 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 1340853004712 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1340853004713 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1340853004714 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 1340853004715 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1340853004716 active site 1340853004717 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 1340853004718 type III secretion system ATPase; Validated; Region: PRK05922 1340853004719 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1340853004720 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1340853004721 Walker A motif; other site 1340853004722 ATP binding site [chemical binding]; other site 1340853004723 Walker B motif; other site 1340853004724 type III secretion system protein; Validated; Region: PRK05934 1340853004725 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1340853004726 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 1340853004727 active site 1340853004728 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1340853004729 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1340853004730 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1340853004731 catalytic residue [active] 1340853004732 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1340853004733 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1340853004734 RNA binding surface [nucleotide binding]; other site 1340853004735 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1340853004736 active site 1340853004737 biotin--protein ligase; Provisional; Region: PRK05935 1340853004738 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1340853004739 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1340853004740 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1340853004741 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1340853004742 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1340853004743 motif II; other site 1340853004744 CCC1-related protein family; Region: CCC1_like_1; cd02437 1340853004745 seryl-tRNA synthetase; Provisional; Region: PRK05431 1340853004746 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1340853004747 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1340853004748 dimer interface [polypeptide binding]; other site 1340853004749 active site 1340853004750 motif 1; other site 1340853004751 motif 2; other site 1340853004752 motif 3; other site 1340853004753 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1340853004754 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1340853004755 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1340853004756 dimerization interface [polypeptide binding]; other site 1340853004757 active site 1340853004758 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1340853004759 homopentamer interface [polypeptide binding]; other site 1340853004760 active site 1340853004761 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1340853004762 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1340853004763 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1340853004764 substrate binding site [chemical binding]; other site 1340853004765 Proteins containing SET domain [General function prediction only]; Region: COG2940 1340853004766 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 1340853004767 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1340853004768 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1340853004769 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1340853004770 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1340853004771 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1340853004772 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 1340853004773 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1340853004774 catalytic loop [active] 1340853004775 iron binding site [ion binding]; other site 1340853004776 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 1340853004777 FAD binding pocket [chemical binding]; other site 1340853004778 FAD binding motif [chemical binding]; other site 1340853004779 phosphate binding motif [ion binding]; other site 1340853004780 beta-alpha-beta structure motif; other site 1340853004781 NAD binding pocket [chemical binding]; other site 1340853004782 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 1340853004783 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1340853004784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1340853004785 S-adenosylmethionine binding site [chemical binding]; other site 1340853004786 Histone H1-like protein Hc1; Region: Hc1; pfam07432 1340853004787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1340853004788 binding surface 1340853004789 TPR motif; other site 1340853004790 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1340853004791 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1340853004792 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1340853004793 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1340853004794 HemN C-terminal domain; Region: HemN_C; pfam06969 1340853004795 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1340853004796 substrate binding site [chemical binding]; other site 1340853004797 active site 1340853004798 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1340853004799 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1340853004800 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1340853004801 ATP binding site [chemical binding]; other site 1340853004802 putative Mg++ binding site [ion binding]; other site 1340853004803 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1340853004804 nucleotide binding region [chemical binding]; other site 1340853004805 ATP-binding site [chemical binding]; other site 1340853004806 TRCF domain; Region: TRCF; pfam03461 1340853004807 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1340853004808 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1340853004809 motif 1; other site 1340853004810 active site 1340853004811 motif 2; other site 1340853004812 motif 3; other site 1340853004813 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1340853004814 DHHA1 domain; Region: DHHA1; pfam02272 1340853004815 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 1340853004816 elongation factor P; Validated; Region: PRK00529 1340853004817 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1340853004818 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1340853004819 RNA binding site [nucleotide binding]; other site 1340853004820 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1340853004821 RNA binding site [nucleotide binding]; other site 1340853004822 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1340853004823 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 1340853004824 putative active site [active] 1340853004825 putative metal binding site [ion binding]; other site 1340853004826 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1340853004827 active site 1340853004828 metal binding site [ion binding]; metal-binding site 1340853004829 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 1340853004830 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1340853004831 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1340853004832 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1340853004833 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1340853004834 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1340853004835 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1340853004836 Mg++ binding site [ion binding]; other site 1340853004837 putative catalytic motif [active] 1340853004838 putative substrate binding site [chemical binding]; other site 1340853004839 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 1340853004840 TrkA-N domain; Region: TrkA_N; pfam02254 1340853004841 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1340853004842 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1340853004843 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1340853004844 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1340853004845 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1340853004846 cell division protein FtsW; Region: ftsW; TIGR02614 1340853004847 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 1340853004848 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1340853004849 active site 1340853004850 homodimer interface [polypeptide binding]; other site 1340853004851 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1340853004852 anti sigma factor interaction site; other site 1340853004853 regulatory phosphorylation site [posttranslational modification]; other site 1340853004854 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1340853004855 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1340853004856 hypothetical protein; Provisional; Region: PRK05927 1340853004857 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1340853004858 FeS/SAM binding site; other site 1340853004859 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1340853004860 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1340853004861 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 1340853004862 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1340853004863 dimer interface [polypeptide binding]; other site 1340853004864 active site 1340853004865 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 1340853004866 active site 1340853004867 Ap4A binding cleft/pocket [chemical binding]; other site 1340853004868 P4 phosphate binding site; other site 1340853004869 nudix motif; other site 1340853004870 putative P2/P3 phosphate binding site [ion binding]; other site 1340853004871 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1340853004872 dimer interface [polypeptide binding]; other site 1340853004873 substrate binding site [chemical binding]; other site 1340853004874 metal binding sites [ion binding]; metal-binding site 1340853004875 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1340853004876 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1340853004877 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1340853004878 NAD binding site [chemical binding]; other site 1340853004879 Phe binding site; other site 1340853004880 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 1340853004881 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1340853004882 active site 1340853004883 putative lithium-binding site [ion binding]; other site 1340853004884 substrate binding site [chemical binding]; other site 1340853004885 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1340853004886 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1340853004887 putative acyl-acceptor binding pocket; other site 1340853004888 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 1340853004889 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1340853004890 acyl-activating enzyme (AAE) consensus motif; other site 1340853004891 AMP binding site [chemical binding]; other site 1340853004892 active site 1340853004893 CoA binding site [chemical binding]; other site 1340853004894 8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937 1340853004895 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1340853004896 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1340853004897 catalytic residue [active] 1340853004898 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 1340853004899 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1340853004900 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1340853004901 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1340853004902 dimer interface [polypeptide binding]; other site 1340853004903 putative anticodon binding site; other site 1340853004904 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1340853004905 motif 1; other site 1340853004906 dimer interface [polypeptide binding]; other site 1340853004907 active site 1340853004908 motif 2; other site 1340853004909 motif 3; other site 1340853004910 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1340853004911 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1340853004912 active site 1340853004913 HIGH motif; other site 1340853004914 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1340853004915 KMSKS motif; other site 1340853004916 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1340853004917 tRNA binding surface [nucleotide binding]; other site 1340853004918 anticodon binding site; other site 1340853004919 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 1340853004920 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1340853004921 ribonuclease P; Reviewed; Region: rnpA; PRK00730 1340853004922 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1340853004923 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1340853004924 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 1340853004925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1340853004926 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1340853004927 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1340853004928 GIY-YIG motif/motif A; other site 1340853004929 active site 1340853004930 catalytic site [active] 1340853004931 putative DNA binding site [nucleotide binding]; other site 1340853004932 metal binding site [ion binding]; metal-binding site 1340853004933 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1340853004934 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1340853004935 MutS domain I; Region: MutS_I; pfam01624 1340853004936 MutS domain II; Region: MutS_II; pfam05188 1340853004937 MutS domain III; Region: MutS_III; pfam05192 1340853004938 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1340853004939 Walker A/P-loop; other site 1340853004940 ATP binding site [chemical binding]; other site 1340853004941 Q-loop/lid; other site 1340853004942 ABC transporter signature motif; other site 1340853004943 Walker B; other site 1340853004944 D-loop; other site 1340853004945 H-loop/switch region; other site 1340853004946 DNA primase; Validated; Region: dnaG; PRK05667 1340853004947 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1340853004948 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1340853004949 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1340853004950 active site 1340853004951 metal binding site [ion binding]; metal-binding site 1340853004952 interdomain interaction site; other site 1340853004953 glycyl-tRNA synthetase; Provisional; Region: PRK14908 1340853004954 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1340853004955 dimer interface [polypeptide binding]; other site 1340853004956 motif 1; other site 1340853004957 active site 1340853004958 motif 2; other site 1340853004959 motif 3; other site 1340853004960 DALR anticodon binding domain; Region: DALR_1; pfam05746 1340853004961 glycogen synthase; Provisional; Region: glgA; PRK00654 1340853004962 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1340853004963 ADP-binding pocket [chemical binding]; other site 1340853004964 homodimer interface [polypeptide binding]; other site 1340853004965 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1340853004966 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1340853004967 5S rRNA interface [nucleotide binding]; other site 1340853004968 CTC domain interface [polypeptide binding]; other site 1340853004969 L16 interface [polypeptide binding]; other site 1340853004970 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1340853004971 putative active site [active] 1340853004972 catalytic residue [active] 1340853004973 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 1340853004974 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1340853004975 Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359 1340853004976 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1340853004977 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1340853004978 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 1340853004979 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 1340853004980 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1340853004981 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1340853004982 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1340853004983 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1340853004984 putative acyl-acceptor binding pocket; other site 1340853004985 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1340853004986 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1340853004987 homodimer interface [polypeptide binding]; other site 1340853004988 oligonucleotide binding site [chemical binding]; other site 1340853004989 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1340853004990 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 1340853004991 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 1340853004992 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1340853004993 YtxH-like protein; Region: YtxH; cl02079 1340853004994 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 1340853004995 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1340853004996 active site 1340853004997 substrate binding site [chemical binding]; other site 1340853004998 metal binding site [ion binding]; metal-binding site 1340853004999 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 1340853005000 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1340853005001 glutaminase active site [active] 1340853005002 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1340853005003 dimer interface [polypeptide binding]; other site 1340853005004 active site 1340853005005 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1340853005006 dimer interface [polypeptide binding]; other site 1340853005007 active site 1340853005008 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 1340853005009 aromatic amino acid transport protein; Region: araaP; TIGR00837 1340853005010 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 1340853005011 aromatic amino acid transport protein; Region: araaP; TIGR00837 1340853005012 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1340853005013 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1340853005014 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 1340853005015 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1340853005016 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 1340853005017 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1340853005018 CoA-ligase; Region: Ligase_CoA; pfam00549 1340853005019 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1340853005020 CoA binding domain; Region: CoA_binding; smart00881 1340853005021 CoA-ligase; Region: Ligase_CoA; pfam00549 1340853005022 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1340853005023 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1340853005024 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1340853005025 protein binding site [polypeptide binding]; other site 1340853005026 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1340853005027 protein binding site [polypeptide binding]; other site 1340853005028 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 1340853005029 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1340853005030 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1340853005031 Peptidase M16C associated; Region: M16C_assoc; pfam08367 1340853005032 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1340853005033 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1340853005034 RmuC family; Region: RmuC; pfam02646 1340853005035 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1340853005036 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1340853005037 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 1340853005038 ATP cone domain; Region: ATP-cone; pfam03477 1340853005039 ATP cone domain; Region: ATP-cone; pfam03477 1340853005040 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1340853005041 active site 1340853005042 dimer interface [polypeptide binding]; other site 1340853005043 catalytic residues [active] 1340853005044 effector binding site; other site 1340853005045 R2 peptide binding site; other site 1340853005046 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1340853005047 dimer interface [polypeptide binding]; other site 1340853005048 putative radical transfer pathway; other site 1340853005049 diiron center [ion binding]; other site 1340853005050 tyrosyl radical; other site 1340853005051 Putative methyltransferase; Region: Methyltransf_4; pfam02390 1340853005052 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1340853005053 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1340853005054 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1340853005055 FAD binding domain; Region: FAD_binding_4; pfam01565 1340853005056 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1340853005057 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1340853005058 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1340853005059 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1340853005060 Ribosomal protein L35 [Translation, ribosomal structure and biogenesis]; Region: RpmI; COG0291 1340853005061 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1340853005062 23S rRNA binding site [nucleotide binding]; other site 1340853005063 L21 binding site [polypeptide binding]; other site 1340853005064 L13 binding site [polypeptide binding]; other site 1340853005065 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1340853005066 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1340853005067 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1340853005068 motif 1; other site 1340853005069 dimer interface [polypeptide binding]; other site 1340853005070 active site 1340853005071 motif 2; other site 1340853005072 motif 3; other site 1340853005073 Predicted permeases [General function prediction only]; Region: COG0795 1340853005074 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1340853005075 Predicted permeases [General function prediction only]; Region: COG0795 1340853005076 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1340853005077 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1340853005078 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1340853005079 Ligand Binding Site [chemical binding]; other site 1340853005080 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1340853005081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1340853005082 Walker A motif; other site 1340853005083 ATP binding site [chemical binding]; other site 1340853005084 Walker B motif; other site 1340853005085 arginine finger; other site 1340853005086 Peptidase family M41; Region: Peptidase_M41; pfam01434 1340853005087 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1340853005088 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1340853005089 RNase E interface [polypeptide binding]; other site 1340853005090 trimer interface [polypeptide binding]; other site 1340853005091 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1340853005092 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1340853005093 RNase E interface [polypeptide binding]; other site 1340853005094 trimer interface [polypeptide binding]; other site 1340853005095 active site 1340853005096 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1340853005097 putative nucleic acid binding region [nucleotide binding]; other site 1340853005098 G-X-X-G motif; other site 1340853005099 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1340853005100 RNA binding site [nucleotide binding]; other site 1340853005101 domain interface; other site 1340853005102 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1340853005103 16S/18S rRNA binding site [nucleotide binding]; other site 1340853005104 S13e-L30e interaction site [polypeptide binding]; other site 1340853005105 25S rRNA binding site [nucleotide binding]; other site 1340853005106 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1340853005107 nucleoside/Zn binding site; other site 1340853005108 dimer interface [polypeptide binding]; other site 1340853005109 catalytic motif [active] 1340853005110 Protein of unknown function (DUF720); Region: DUF720; pfam05302 1340853005111 Protein of unknown function (DUF720); Region: DUF720; pfam05302 1340853005112 Protein of unknown function (DUF720); Region: DUF720; pfam05302 1340853005113 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1340853005114 methionine aminopeptidase; Provisional; Region: PRK12318 1340853005115 SEC-C motif; Region: SEC-C; pfam02810 1340853005116 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1340853005117 active site 1340853005118 MarC family integral membrane protein; Region: MarC; pfam01914 1340853005119 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1340853005120 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1340853005121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1340853005122 dimer interface [polypeptide binding]; other site 1340853005123 conserved gate region; other site 1340853005124 putative PBP binding loops; other site 1340853005125 ABC-ATPase subunit interface; other site 1340853005126 NMT1/THI5 like; Region: NMT1; pfam09084 1340853005127 fumarate hydratase, class II; Region: fumC_II; TIGR00979 1340853005128 Class II fumarases; Region: Fumarase_classII; cd01362 1340853005129 active site 1340853005130 tetramer interface [polypeptide binding]; other site 1340853005131 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1340853005132 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1340853005133 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1340853005134 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1340853005135 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 1340853005136 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1340853005137 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1340853005138 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1340853005139 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 1340853005140 active site triad [active] 1340853005141 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1340853005142 LytB protein; Region: LYTB; pfam02401 1340853005143 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 1340853005144 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 1340853005145 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1340853005146 binding surface 1340853005147 TPR motif; other site 1340853005148 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1340853005149 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1340853005150 active site 1340853005151 DNA binding site [nucleotide binding] 1340853005152 Int/Topo IB signature motif; other site 1340853005153 glycogen branching enzyme; Provisional; Region: PRK05402 1340853005154 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1340853005155 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1340853005156 active site 1340853005157 catalytic site [active] 1340853005158 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1340853005159 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 1340853005160 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 1340853005161 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 1340853005162 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1340853005163 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 1340853005164 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 1340853005165 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1340853005166 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 1340853005167 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1340853005168 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 1340853005169 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 1340853005170 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1340853005171 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 1340853005172 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 1340853005173 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 1340853005174 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 1340853005175 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813005176 Uncharacterized conserved protein [Function unknown]; Region: COG2155 813005177 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 813005178 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 813005179 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 813005180 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 813005181 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 813005182 GatB domain; Region: GatB_Yqey; pfam02637 813005183 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 813005184 ribonuclease HIII; Region: rnhC; TIGR00716 813005185 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 813005186 RNA/DNA hybrid binding site [nucleotide binding]; other site 813005187 active site 813005188 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 813005189 Helix-turn-helix domain; Region: HTH_25; pfam13413 813005190 Uncharacterized conserved protein [Function unknown]; Region: COG1624 813005191 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 813005192 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 813005193 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 813005194 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 813005195 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 813005196 putative active site [active] 813005197 PhoH-like protein; Region: PhoH; pfam02562 813005198 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 813005199 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 813005200 HIGH motif; other site 813005201 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 813005202 active site 813005203 KMSKS motif; other site 813005204 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 813005205 tRNA binding surface [nucleotide binding]; other site 813005206 anticodon binding site; other site 813005207 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 813005208 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 813005209 Catalytic site [active] 813005210 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 813005211 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 813005212 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 813005213 peptide chain release factor 1; Validated; Region: prfA; PRK00591 813005214 PCRF domain; Region: PCRF; pfam03462 813005215 RF-1 domain; Region: RF-1; pfam00472 813005216 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 813005217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813005218 S-adenosylmethionine binding site [chemical binding]; other site 813005219 signal recognition particle protein; Provisional; Region: PRK10867 813005220 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 813005221 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 813005222 P loop; other site 813005223 GTP binding site [chemical binding]; other site 813005224 Signal peptide binding domain; Region: SRP_SPB; pfam02978 813005225 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 813005226 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 813005227 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 813005228 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 813005229 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 813005230 RNA/DNA hybrid binding site [nucleotide binding]; other site 813005231 active site 813005232 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 813005233 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 813005234 catalytic site [active] 813005235 G-X2-G-X-G-K; other site 813005236 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 813005237 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 813005238 active site 813005239 HIGH motif; other site 813005240 KMSKS motif; other site 813005241 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 813005242 tRNA binding surface [nucleotide binding]; other site 813005243 anticodon binding site; other site 813005244 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 813005245 AAA domain; Region: AAA_30; pfam13604 813005246 Family description; Region: UvrD_C_2; pfam13538 813005247 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 813005248 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 813005249 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 813005250 conserved cys residue [active] 813005251 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 813005252 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 813005253 trimer interface [polypeptide binding]; other site 813005254 active site 813005255 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 813005256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813005257 Walker A motif; other site 813005258 ATP binding site [chemical binding]; other site 813005259 Walker B motif; other site 813005260 arginine finger; other site 813005261 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 813005262 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813005263 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 813005264 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 813005265 dimer interface [polypeptide binding]; other site 813005266 ssDNA binding site [nucleotide binding]; other site 813005267 tetramer (dimer of dimers) interface [polypeptide binding]; other site 813005268 multifunctional aminopeptidase A; Provisional; Region: PRK00913 813005269 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 813005270 interface (dimer of trimers) [polypeptide binding]; other site 813005271 Substrate-binding/catalytic site; other site 813005272 Zn-binding sites [ion binding]; other site 813005273 Predicted methyltransferases [General function prediction only]; Region: COG0313 813005274 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 813005275 putative SAM binding site [chemical binding]; other site 813005276 homodimer interface [polypeptide binding]; other site 813005277 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 813005278 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813005279 FeS/SAM binding site; other site 813005280 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 813005281 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 813005282 TPP-binding site [chemical binding]; other site 813005283 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 813005284 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 813005285 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813005286 E3 interaction surface; other site 813005287 lipoyl attachment site [posttranslational modification]; other site 813005288 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813005289 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 813005290 ADP-ribose binding site [chemical binding]; other site 813005291 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 813005292 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 813005293 catalytic loop [active] 813005294 iron binding site [ion binding]; other site 813005295 type III secretion system protein; Validated; Region: PRK05910 813005296 FHIPEP family; Region: FHIPEP; pfam00771 813005297 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 813005298 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 813005299 active site 813005300 HIGH motif; other site 813005301 dimer interface [polypeptide binding]; other site 813005302 KMSKS motif; other site 813005303 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813005304 RNA binding surface [nucleotide binding]; other site 813005305 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 813005306 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 813005307 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 813005308 GTP-binding protein LepA; Provisional; Region: PRK05433 813005309 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 813005310 G1 box; other site 813005311 putative GEF interaction site [polypeptide binding]; other site 813005312 GTP/Mg2+ binding site [chemical binding]; other site 813005313 Switch I region; other site 813005314 G2 box; other site 813005315 G3 box; other site 813005316 Switch II region; other site 813005317 G4 box; other site 813005318 G5 box; other site 813005319 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 813005320 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 813005321 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 813005322 ADP/ATP carrier protein family; Region: AAA; TIGR00769 813005323 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 813005324 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 813005325 intersubunit interface [polypeptide binding]; other site 813005326 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 813005327 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 813005328 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813005329 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813005330 ABC-ATPase subunit interface; other site 813005331 dimer interface [polypeptide binding]; other site 813005332 putative PBP binding regions; other site 813005333 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 813005334 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 813005335 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813005336 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813005337 ABC-ATPase subunit interface; other site 813005338 dimer interface [polypeptide binding]; other site 813005339 putative PBP binding regions; other site 813005340 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 813005341 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 813005342 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 813005343 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 813005344 RIP metalloprotease RseP; Region: TIGR00054 813005345 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 813005346 active site 813005347 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 813005348 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 813005349 putative substrate binding region [chemical binding]; other site 813005350 recF protein; Region: recf; TIGR00611 813005351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813005352 Walker A/P-loop; other site 813005353 ATP binding site [chemical binding]; other site 813005354 Q-loop/lid; other site 813005355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813005356 ABC transporter signature motif; other site 813005357 Walker B; other site 813005358 DNA polymerase III subunit beta; Validated; Region: PRK05643 813005359 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 813005360 putative DNA binding surface [nucleotide binding]; other site 813005361 dimer interface [polypeptide binding]; other site 813005362 beta-clamp/clamp loader binding surface; other site 813005363 beta-clamp/translesion DNA polymerase binding surface; other site 813005364 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 813005365 SmpB-tmRNA interface; other site 813005366 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 813005367 ApbE family; Region: ApbE; pfam02424 813005368 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 813005369 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 813005370 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 813005371 homodimer interface [polypeptide binding]; other site 813005372 NADP binding site [chemical binding]; other site 813005373 substrate binding site [chemical binding]; other site 813005374 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813005375 PLD-like domain; Region: PLDc_2; pfam13091 813005376 putative active site [active] 813005377 catalytic site [active] 813005378 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813005379 PLD-like domain; Region: PLDc_2; pfam13091 813005380 putative active site [active] 813005381 catalytic site [active] 813005382 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 813005383 4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446 813005384 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813005385 HrpJ-like domain; Region: HrpJ; cl15454 813005386 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 813005387 FHIPEP family; Region: FHIPEP; pfam00771 813005388 type III secretion system protein; Validated; Region: PRK06298 813005389 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 813005390 GTP-binding protein YchF; Reviewed; Region: PRK09601 813005391 YchF GTPase; Region: YchF; cd01900 813005392 G1 box; other site 813005393 GTP/Mg2+ binding site [chemical binding]; other site 813005394 Switch I region; other site 813005395 G2 box; other site 813005396 Switch II region; other site 813005397 G3 box; other site 813005398 G4 box; other site 813005399 G5 box; other site 813005400 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 813005401 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 813005402 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 813005403 active site 813005404 Riboflavin kinase; Region: Flavokinase; smart00904 813005405 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 813005406 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 813005407 RNA binding site [nucleotide binding]; other site 813005408 active site 813005409 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 813005410 transcription termination factor NusA; Region: NusA; TIGR01953 813005411 NusA N-terminal domain; Region: NusA_N; pfam08529 813005412 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 813005413 RNA binding site [nucleotide binding]; other site 813005414 homodimer interface [polypeptide binding]; other site 813005415 NusA-like KH domain; Region: KH_5; pfam13184 813005416 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 813005417 G-X-X-G motif; other site 813005418 ribosomal protein S1; Region: rpsA; TIGR00717 813005419 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 813005420 RNA binding site [nucleotide binding]; other site 813005421 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 813005422 RNA binding site [nucleotide binding]; other site 813005423 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813005424 RNA binding site [nucleotide binding]; other site 813005425 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813005426 RNA binding site [nucleotide binding]; other site 813005427 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 813005428 RNA binding site [nucleotide binding]; other site 813005429 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 813005430 RNA binding site [nucleotide binding]; other site 813005431 domain interface; other site 813005432 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 813005433 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 813005434 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 813005435 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 813005436 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 813005437 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 813005438 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 813005439 active site 813005440 motif I; other site 813005441 motif II; other site 813005442 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 813005443 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 813005444 NAD binding site [chemical binding]; other site 813005445 homotetramer interface [polypeptide binding]; other site 813005446 homodimer interface [polypeptide binding]; other site 813005447 substrate binding site [chemical binding]; other site 813005448 active site 813005449 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 813005450 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813005451 RNA binding surface [nucleotide binding]; other site 813005452 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 813005453 active site 813005454 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 813005455 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 813005456 minor groove reading motif; other site 813005457 helix-hairpin-helix signature motif; other site 813005458 substrate binding pocket [chemical binding]; other site 813005459 active site 813005460 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 813005461 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 813005462 DNA binding and oxoG recognition site [nucleotide binding] 813005463 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 813005464 oligomerisation interface [polypeptide binding]; other site 813005465 mobile loop; other site 813005466 roof hairpin; other site 813005467 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 813005468 Clp amino terminal domain; Region: Clp_N; pfam02861 813005469 Clp amino terminal domain; Region: Clp_N; pfam02861 813005470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813005471 Walker A motif; other site 813005472 ATP binding site [chemical binding]; other site 813005473 Walker B motif; other site 813005474 arginine finger; other site 813005475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813005476 Walker A motif; other site 813005477 ATP binding site [chemical binding]; other site 813005478 Walker B motif; other site 813005479 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 813005480 IncA protein; Region: IncA; pfam04156 813005481 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 813005482 elongation factor P; Provisional; Region: PRK12426 813005483 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813005484 RNA binding site [nucleotide binding]; other site 813005485 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 813005486 RNA binding site [nucleotide binding]; other site 813005487 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 813005488 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 813005489 carboxyltransferase (CT) interaction site; other site 813005490 biotinylation site [posttranslational modification]; other site 813005491 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 813005492 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 813005493 ATP-grasp domain; Region: ATP-grasp_4; cl17255 813005494 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 813005495 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 813005496 23S rRNA interface [nucleotide binding]; other site 813005497 L3 interface [polypeptide binding]; other site 813005498 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 813005499 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 813005500 NlpC/P60 family; Region: NLPC_P60; cl17555 813005501 adenylate kinase; Reviewed; Region: adk; PRK00279 813005502 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 813005503 AMP-binding site [chemical binding]; other site 813005504 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 813005505 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 813005506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813005507 dimer interface [polypeptide binding]; other site 813005508 conserved gate region; other site 813005509 putative PBP binding loops; other site 813005510 ABC-ATPase subunit interface; other site 813005511 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 813005512 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813005513 Walker A/P-loop; other site 813005514 ATP binding site [chemical binding]; other site 813005515 Q-loop/lid; other site 813005516 ABC transporter signature motif; other site 813005517 Walker B; other site 813005518 D-loop; other site 813005519 H-loop/switch region; other site 813005520 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 813005521 Methyltransferase domain; Region: Methyltransf_23; pfam13489 813005522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813005523 S-adenosylmethionine binding site [chemical binding]; other site 813005524 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 813005525 Serine hydrolase (FSH1); Region: FSH1; pfam03959 813005526 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 813005527 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 813005528 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 813005529 active site 813005530 conserved hypothetical integral membrane protein; Region: TIGR00697 813005531 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 813005532 SEC-C motif; Region: SEC-C; pfam02810 813005533 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 813005534 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813005535 active site 813005536 ATP binding site [chemical binding]; other site 813005537 substrate binding site [chemical binding]; other site 813005538 activation loop (A-loop); other site 813005539 Uncharacterized conserved protein [Function unknown]; Region: COG1262 813005540 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 813005541 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 813005542 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 813005543 nucleotide binding pocket [chemical binding]; other site 813005544 K-X-D-G motif; other site 813005545 catalytic site [active] 813005546 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 813005547 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 813005548 Helix-hairpin-helix motif; Region: HHH; pfam00633 813005549 helix-hairpin-helix signature motif; other site 813005550 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 813005551 Dimer interface [polypeptide binding]; other site 813005552 BRCT sequence motif; other site 813005553 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 813005554 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 813005555 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 813005556 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 813005557 FtsX-like permease family; Region: FtsX; pfam02687 813005558 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 813005559 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 813005560 Walker A/P-loop; other site 813005561 ATP binding site [chemical binding]; other site 813005562 Q-loop/lid; other site 813005563 ABC transporter signature motif; other site 813005564 Walker B; other site 813005565 D-loop; other site 813005566 H-loop/switch region; other site 813005567 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813005568 PLD-like domain; Region: PLDc_2; pfam13091 813005569 putative active site [active] 813005570 catalytic site [active] 813005571 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813005572 PLD-like domain; Region: PLDc_2; pfam13091 813005573 putative active site [active] 813005574 catalytic site [active] 813005575 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813005576 PLD-like domain; Region: PLDc_2; pfam13091 813005577 putative active site [active] 813005578 catalytic site [active] 813005579 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813005580 PLD-like domain; Region: PLDc_2; pfam13091 813005581 putative active site [active] 813005582 catalytic site [active] 813005583 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813005584 PLD-like domain; Region: PLDc_2; pfam13091 813005585 putative active site [active] 813005586 catalytic site [active] 813005587 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813005588 PLD-like domain; Region: PLDc_2; pfam13091 813005589 putative active site [active] 813005590 catalytic site [active] 813005591 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813005592 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 813005593 trp operon repressor, proteobacterial; Region: TrpR; TIGR01321 813005594 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 813005595 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 813005596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813005597 catalytic residue [active] 813005598 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 813005599 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 813005600 substrate binding site [chemical binding]; other site 813005601 active site 813005602 catalytic residues [active] 813005603 heterodimer interface [polypeptide binding]; other site 813005604 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 813005605 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 813005606 peptide binding site [polypeptide binding]; other site 813005607 putative disulfide oxidoreductase; Provisional; Region: PRK00611 813005608 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 813005609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813005610 Walker A/P-loop; other site 813005611 ATP binding site [chemical binding]; other site 813005612 Q-loop/lid; other site 813005613 ABC transporter signature motif; other site 813005614 Walker B; other site 813005615 D-loop; other site 813005616 H-loop/switch region; other site 813005617 CTP synthetase; Validated; Region: pyrG; PRK05380 813005618 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 813005619 Catalytic site [active] 813005620 active site 813005621 UTP binding site [chemical binding]; other site 813005622 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 813005623 active site 813005624 putative oxyanion hole; other site 813005625 catalytic triad [active] 813005626 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 813005627 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 813005628 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 813005629 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 813005630 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 813005631 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 813005632 putative active site [active] 813005633 DNA polymerase III subunit delta'; Validated; Region: PRK05917 813005634 DNA polymerase III subunit delta'; Validated; Region: PRK08485 813005635 thymidylate kinase; Validated; Region: tmk; PRK00698 813005636 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 813005637 TMP-binding site; other site 813005638 ATP-binding site [chemical binding]; other site 813005639 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 813005640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813005641 ATP binding site [chemical binding]; other site 813005642 Mg2+ binding site [ion binding]; other site 813005643 G-X-G motif; other site 813005644 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 813005645 anchoring element; other site 813005646 dimer interface [polypeptide binding]; other site 813005647 ATP binding site [chemical binding]; other site 813005648 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 813005649 active site 813005650 putative metal-binding site [ion binding]; other site 813005651 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 813005652 Protein of unknown function (DUF721); Region: DUF721; pfam05258 813005653 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 813005654 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 813005655 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 813005656 MgtE intracellular N domain; Region: MgtE_N; pfam03448 813005657 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 813005658 Divalent cation transporter; Region: MgtE; pfam01769 813005659 UGMP family protein; Validated; Region: PRK09604 813005660 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 813005661 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 813005662 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 813005663 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 813005664 peptide binding site [polypeptide binding]; other site 813005665 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 813005666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813005667 dimer interface [polypeptide binding]; other site 813005668 conserved gate region; other site 813005669 putative PBP binding loops; other site 813005670 ABC-ATPase subunit interface; other site 813005671 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 813005672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813005673 dimer interface [polypeptide binding]; other site 813005674 conserved gate region; other site 813005675 putative PBP binding loops; other site 813005676 ABC-ATPase subunit interface; other site 813005677 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813005678 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 813005679 Walker A/P-loop; other site 813005680 ATP binding site [chemical binding]; other site 813005681 Q-loop/lid; other site 813005682 ABC transporter signature motif; other site 813005683 Walker B; other site 813005684 D-loop; other site 813005685 H-loop/switch region; other site 813005686 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 813005687 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 813005688 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813005689 Walker A/P-loop; other site 813005690 ATP binding site [chemical binding]; other site 813005691 Q-loop/lid; other site 813005692 ABC transporter signature motif; other site 813005693 Walker B; other site 813005694 D-loop; other site 813005695 H-loop/switch region; other site 813005696 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813005697 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 813005698 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 813005699 transmembrane helices; other site 813005700 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 813005701 active site 813005702 ADP/pyrophosphate binding site [chemical binding]; other site 813005703 dimerization interface [polypeptide binding]; other site 813005704 allosteric effector site; other site 813005705 fructose-1,6-bisphosphate binding site; other site 813005706 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 813005707 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 813005708 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 813005709 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 813005710 active site 813005711 ADP/pyrophosphate binding site [chemical binding]; other site 813005712 dimerization interface [polypeptide binding]; other site 813005713 allosteric effector site; other site 813005714 fructose-1,6-bisphosphate binding site; other site 813005715 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 813005716 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 813005717 Putative transcriptional regulator [Transcription]; Region: COG1678 813005718 Uncharacterized conserved protein [Function unknown]; Region: COG1259 813005719 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 813005720 tetramer (dimer of dimers) interface [polypeptide binding]; other site 813005721 active site 813005722 dimer interface [polypeptide binding]; other site 813005723 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 813005724 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 813005725 putative active site; other site 813005726 catalytic residue [active] 813005727 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 813005728 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 813005729 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 813005730 Ligand Binding Site [chemical binding]; other site 813005731 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 813005732 prenyltransferase; Reviewed; Region: ubiA; PRK12876 813005733 UbiA prenyltransferase family; Region: UbiA; pfam01040 813005734 aromatic acid decarboxylase; Validated; Region: PRK05920 813005735 Flavoprotein; Region: Flavoprotein; pfam02441 813005736 Uncharacterized conserved protein [Function unknown]; Region: COG1284 813005737 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 813005738 IncA protein; Region: IncA; pfam04156 813005739 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 813005740 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 813005741 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 813005742 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 813005743 Na2 binding site [ion binding]; other site 813005744 putative substrate binding site 1 [chemical binding]; other site 813005745 Na binding site 1 [ion binding]; other site 813005746 putative substrate binding site 2 [chemical binding]; other site 813005747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813005748 putative substrate translocation pore; other site 813005749 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 813005750 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 813005751 ligand binding site [chemical binding]; other site 813005752 flexible hinge region; other site 813005753 acyl carrier protein; Provisional; Region: acpP; PRK00982 813005754 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 813005755 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 813005756 NAD(P) binding site [chemical binding]; other site 813005757 homotetramer interface [polypeptide binding]; other site 813005758 homodimer interface [polypeptide binding]; other site 813005759 active site 813005760 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 813005761 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 813005762 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 813005763 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 813005764 dimer interface [polypeptide binding]; other site 813005765 active site 813005766 CoA binding pocket [chemical binding]; other site 813005767 recombination protein RecR; Region: recR; TIGR00615 813005768 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 813005769 putative active site [active] 813005770 putative metal-binding site [ion binding]; other site 813005771 tetramer interface [polypeptide binding]; other site 813005772 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 813005773 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813005774 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813005775 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813005776 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813005777 Surface antigen; Region: Bac_surface_Ag; pfam01103 813005778 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 813005779 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 813005780 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 813005781 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 813005782 trimer interface [polypeptide binding]; other site 813005783 active site 813005784 UDP-GlcNAc binding site [chemical binding]; other site 813005785 lipid binding site [chemical binding]; lipid-binding site 813005786 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 813005787 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 813005788 tetramer interface [polypeptide binding]; other site 813005789 TPP-binding site [chemical binding]; other site 813005790 heterodimer interface [polypeptide binding]; other site 813005791 phosphorylation loop region [posttranslational modification] 813005792 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 813005793 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 813005794 alpha subunit interface [polypeptide binding]; other site 813005795 TPP binding site [chemical binding]; other site 813005796 heterodimer interface [polypeptide binding]; other site 813005797 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813005798 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 813005799 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813005800 E3 interaction surface; other site 813005801 lipoyl attachment site [posttranslational modification]; other site 813005802 e3 binding domain; Region: E3_binding; pfam02817 813005803 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813005804 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 813005805 homodimer interface [polypeptide binding]; other site 813005806 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 813005807 active site pocket [active] 813005808 chromosomal replication initiation protein; Provisional; Region: PRK12422 813005809 DnaA N-terminal domain; Region: DnaA_N; pfam11638 813005810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813005811 Walker A motif; other site 813005812 ATP binding site [chemical binding]; other site 813005813 Walker B motif; other site 813005814 arginine finger; other site 813005815 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 813005816 DnaA box-binding interface [nucleotide binding]; other site 813005817 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 813005818 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 813005819 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 813005820 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 813005821 homodimer interface [polypeptide binding]; other site 813005822 metal binding site [ion binding]; metal-binding site 813005823 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 813005824 Domain of unknown function DUF21; Region: DUF21; pfam01595 813005825 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813005826 Transporter associated domain; Region: CorC_HlyC; smart01091 813005827 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 813005828 Domain of unknown function DUF21; Region: DUF21; pfam01595 813005829 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813005830 Transporter associated domain; Region: CorC_HlyC; smart01091 813005831 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 813005832 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 813005833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813005834 catalytic residue [active] 813005835 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 813005836 Protein phosphatase 2C; Region: PP2C; pfam00481 813005837 active site 813005838 Uncharacterized conserved protein [Function unknown]; Region: COG5465 813005839 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 813005840 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 813005841 active site 813005842 catalytic site [active] 813005843 substrate binding site [chemical binding]; other site 813005844 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 813005845 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 813005846 nucleosidase; Provisional; Region: PRK05634 813005847 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 813005848 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 813005849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813005850 Walker A/P-loop; other site 813005851 ATP binding site [chemical binding]; other site 813005852 Q-loop/lid; other site 813005853 ABC transporter signature motif; other site 813005854 Walker B; other site 813005855 D-loop; other site 813005856 H-loop/switch region; other site 813005857 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 813005858 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 813005859 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 813005860 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 813005861 active site 813005862 metal binding site [ion binding]; metal-binding site 813005863 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 813005864 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 813005865 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813005866 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813005867 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 813005868 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 813005869 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 813005870 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 813005871 MraW methylase family; Region: Methyltransf_5; pfam01795 813005872 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 813005873 DnaA N-terminal domain; Region: DnaA_N; pfam11638 813005874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813005875 Walker A motif; other site 813005876 ATP binding site [chemical binding]; other site 813005877 Walker B motif; other site 813005878 arginine finger; other site 813005879 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 813005880 DnaA box-binding interface [nucleotide binding]; other site 813005881 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 813005882 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 813005883 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 813005884 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 813005885 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 813005886 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 813005887 lipoyl attachment site [posttranslational modification]; other site 813005888 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 813005889 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 813005890 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813005891 putative active site [active] 813005892 catalytic site [active] 813005893 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813005894 putative active site [active] 813005895 catalytic site [active] 813005896 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 813005897 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 813005898 Clp amino terminal domain; Region: Clp_N; pfam02861 813005899 Clp amino terminal domain; Region: Clp_N; pfam02861 813005900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813005901 Walker A motif; other site 813005902 ATP binding site [chemical binding]; other site 813005903 Walker B motif; other site 813005904 arginine finger; other site 813005905 UvrB/uvrC motif; Region: UVR; pfam02151 813005906 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813005907 Walker A motif; other site 813005908 ATP binding site [chemical binding]; other site 813005909 Walker B motif; other site 813005910 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 813005911 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 813005912 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 813005913 Ligand Binding Site [chemical binding]; other site 813005914 Helix-turn-helix domain; Region: HTH_17; pfam12728 813005915 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 813005916 active site 813005917 phosphorylation site [posttranslational modification] 813005918 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 813005919 active site 813005920 phosphorylation site [posttranslational modification] 813005921 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 813005922 trimer interface [polypeptide binding]; other site 813005923 active site 813005924 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 813005925 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 813005926 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 813005927 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 813005928 active site 813005929 substrate binding site [chemical binding]; other site 813005930 metal binding site [ion binding]; metal-binding site 813005931 ribonuclease III; Reviewed; Region: rnc; PRK00102 813005932 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 813005933 dimerization interface [polypeptide binding]; other site 813005934 active site 813005935 metal binding site [ion binding]; metal-binding site 813005936 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 813005937 dsRNA binding site [nucleotide binding]; other site 813005938 DNA repair protein RadA; Provisional; Region: PRK11823 813005939 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 813005940 Walker A motif/ATP binding site; other site 813005941 ATP binding site [chemical binding]; other site 813005942 Walker B motif; other site 813005943 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 813005944 porphobilinogen deaminase; Provisional; Region: PRK01066 813005945 Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379 813005946 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 813005947 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813005948 active site 813005949 ATP binding site [chemical binding]; other site 813005950 substrate binding site [chemical binding]; other site 813005951 activation loop (A-loop); other site 813005952 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 813005953 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 813005954 HIGH motif; other site 813005955 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 813005956 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 813005957 active site 813005958 KMSKS motif; other site 813005959 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 813005960 tRNA binding surface [nucleotide binding]; other site 813005961 anticodon binding site; other site 813005962 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 813005963 V-type ATP synthase subunit K; Provisional; Region: PRK09621 813005964 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 813005965 V-type ATP synthase subunit I; Validated; Region: PRK05771 813005966 Protein of unknown function (DUF1319); Region: DUF1319; pfam07028 813005967 V-type ATP synthase subunit B; Provisional; Region: PRK02118 813005968 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813005969 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 813005970 Walker A motif homologous position; other site 813005971 Walker B motif; other site 813005972 V-type ATP synthase subunit A; Provisional; Region: PRK04192 813005973 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813005974 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 813005975 Walker A motif/ATP binding site; other site 813005976 Walker B motif; other site 813005977 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 813005978 V-type ATP synthase subunit E; Provisional; Region: PRK01005 813005979 V-type ATP synthase subunit E; Provisional; Region: PRK01558 813005980 transaldolase-like protein; Provisional; Region: PTZ00411 813005981 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 813005982 active site 813005983 dimer interface [polypeptide binding]; other site 813005984 catalytic residue [active] 813005985 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 813005986 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 813005987 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 813005988 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 813005989 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 813005990 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 813005991 RPB12 interaction site [polypeptide binding]; other site 813005992 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 813005993 RPB3 interaction site [polypeptide binding]; other site 813005994 RPB1 interaction site [polypeptide binding]; other site 813005995 RPB11 interaction site [polypeptide binding]; other site 813005996 RPB10 interaction site [polypeptide binding]; other site 813005997 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 813005998 L11 interface [polypeptide binding]; other site 813005999 putative EF-Tu interaction site [polypeptide binding]; other site 813006000 putative EF-G interaction site [polypeptide binding]; other site 813006001 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 813006002 23S rRNA interface [nucleotide binding]; other site 813006003 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 813006004 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 813006005 mRNA/rRNA interface [nucleotide binding]; other site 813006006 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 813006007 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 813006008 putative thiostrepton binding site; other site 813006009 23S rRNA interface [nucleotide binding]; other site 813006010 L7/L12 interface [polypeptide binding]; other site 813006011 L25 interface [polypeptide binding]; other site 813006012 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 813006013 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 813006014 putative homodimer interface [polypeptide binding]; other site 813006015 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 813006016 heterodimer interface [polypeptide binding]; other site 813006017 homodimer interface [polypeptide binding]; other site 813006018 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 813006019 elongation factor Tu; Reviewed; Region: PRK12735 813006020 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 813006021 G1 box; other site 813006022 GEF interaction site [polypeptide binding]; other site 813006023 GTP/Mg2+ binding site [chemical binding]; other site 813006024 Switch I region; other site 813006025 G2 box; other site 813006026 G3 box; other site 813006027 Switch II region; other site 813006028 G4 box; other site 813006029 G5 box; other site 813006030 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 813006031 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 813006032 Antibiotic Binding Site [chemical binding]; other site 813006033 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 813006034 rRNA binding site [nucleotide binding]; other site 813006035 predicted 30S ribosome binding site; other site 813006036 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 813006037 Protein of unknown function (DUF687); Region: DUF687; pfam05095 813006038 Protein of unknown function (DUF687); Region: DUF687; pfam05095 813006039 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 813006040 active site 813006041 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 813006042 triosephosphate isomerase; Provisional; Region: PRK14565 813006043 substrate binding site [chemical binding]; other site 813006044 dimer interface [polypeptide binding]; other site 813006045 catalytic triad [active] 813006046 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 813006047 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 813006048 generic binding surface II; other site 813006049 generic binding surface I; other site 813006050 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 813006051 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 813006052 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 813006053 TPP-binding site [chemical binding]; other site 813006054 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 813006055 PYR/PP interface [polypeptide binding]; other site 813006056 dimer interface [polypeptide binding]; other site 813006057 TPP binding site [chemical binding]; other site 813006058 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813006059 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 813006060 pyruvate kinase; Region: pyruv_kin; TIGR01064 813006061 domain interfaces; other site 813006062 active site 813006063 excinuclease ABC subunit A; Provisional; Region: PRK00635 813006064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813006065 Walker A/P-loop; other site 813006066 ATP binding site [chemical binding]; other site 813006067 Q-loop/lid; other site 813006068 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 813006069 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 813006070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813006071 Walker A/P-loop; other site 813006072 ATP binding site [chemical binding]; other site 813006073 Q-loop/lid; other site 813006074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813006075 ABC transporter signature motif; other site 813006076 Walker B; other site 813006077 D-loop; other site 813006078 H-loop/switch region; other site 813006079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813006080 Walker A/P-loop; other site 813006081 ATP binding site [chemical binding]; other site 813006082 Q-loop/lid; other site 813006083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813006084 Q-loop/lid; other site 813006085 ABC transporter signature motif; other site 813006086 Walker B; other site 813006087 D-loop; other site 813006088 H-loop/switch region; other site 813006089 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 813006090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813006091 Walker A motif; other site 813006092 ATP binding site [chemical binding]; other site 813006093 Walker B motif; other site 813006094 arginine finger; other site 813006095 hypothetical protein; Validated; Region: PRK00153 813006096 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 813006097 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 813006098 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 813006099 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 813006100 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 813006101 Competence protein; Region: Competence; pfam03772 813006102 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 813006103 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 813006104 tetramer interface [polypeptide binding]; other site 813006105 TPP-binding site [chemical binding]; other site 813006106 heterodimer interface [polypeptide binding]; other site 813006107 phosphorylation loop region [posttranslational modification] 813006108 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 813006109 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 813006110 alpha subunit interface [polypeptide binding]; other site 813006111 TPP binding site [chemical binding]; other site 813006112 heterodimer interface [polypeptide binding]; other site 813006113 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813006114 chaperone protein DnaJ; Provisional; Region: PRK14284 813006115 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 813006116 HSP70 interaction site [polypeptide binding]; other site 813006117 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 813006118 Zn binding sites [ion binding]; other site 813006119 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 813006120 dimer interface [polypeptide binding]; other site 813006121 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 813006122 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 813006123 Glycoprotease family; Region: Peptidase_M22; pfam00814 813006124 ribonuclease Z; Region: RNase_Z; TIGR02651 813006125 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 813006126 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 813006127 active site 813006128 Int/Topo IB signature motif; other site 813006129 Maf-like protein; Region: Maf; pfam02545 813006130 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 813006131 active site 813006132 dimer interface [polypeptide binding]; other site 813006133 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 813006134 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 813006135 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 813006136 active site 813006137 catalytic residues [active] 813006138 metal binding site [ion binding]; metal-binding site 813006139 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 813006140 dimethyladenosine transferase; Region: ksgA; TIGR00755 813006141 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 813006142 dihydrodipicolinate synthase; Region: dapA; TIGR00674 813006143 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 813006144 inhibitor site; inhibition site 813006145 active site 813006146 dimer interface [polypeptide binding]; other site 813006147 catalytic residue [active] 813006148 aspartate kinase; Provisional; Region: PRK05925 813006149 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 813006150 putative catalytic residues [active] 813006151 nucleotide binding site [chemical binding]; other site 813006152 aspartate binding site [chemical binding]; other site 813006153 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 813006154 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 813006155 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 813006156 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 813006157 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 813006158 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 813006159 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 813006160 hinge; other site 813006161 active site 813006162 shikimate kinase; Provisional; Region: PRK00625 813006163 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 813006164 ADP binding site [chemical binding]; other site 813006165 magnesium binding site [ion binding]; other site 813006166 putative shikimate binding site; other site 813006167 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 813006168 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 813006169 Tetramer interface [polypeptide binding]; other site 813006170 active site 813006171 FMN-binding site [chemical binding]; other site 813006172 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 813006173 active site 813006174 dimer interface [polypeptide binding]; other site 813006175 metal binding site [ion binding]; metal-binding site 813006176 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 813006177 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 813006178 active site 813006179 catalytic residue [active] 813006180 dimer interface [polypeptide binding]; other site 813006181 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 813006182 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 813006183 shikimate binding site; other site 813006184 NAD(P) binding site [chemical binding]; other site 813006185 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 813006186 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 813006187 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 813006188 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 813006189 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 813006190 malate dehydrogenase; Provisional; Region: PRK05442 813006191 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 813006192 NAD(P) binding site [chemical binding]; other site 813006193 dimer interface [polypeptide binding]; other site 813006194 malate binding site [chemical binding]; other site 813006195 GTPases [General function prediction only]; Region: HflX; COG2262 813006196 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 813006197 HflX GTPase family; Region: HflX; cd01878 813006198 G1 box; other site 813006199 GTP/Mg2+ binding site [chemical binding]; other site 813006200 Switch I region; other site 813006201 G2 box; other site 813006202 G3 box; other site 813006203 Switch II region; other site 813006204 G4 box; other site 813006205 G5 box; other site 813006206 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 813006207 putative hydrolase; Provisional; Region: PRK02113 813006208 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 813006209 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 813006210 substrate binding pocket [chemical binding]; other site 813006211 membrane-bound complex binding site; other site 813006212 hinge residues; other site 813006213 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 813006214 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 813006215 nucleotide binding site/active site [active] 813006216 Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286 813006217 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 813006218 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 813006219 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 813006220 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 813006221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813006222 homodimer interface [polypeptide binding]; other site 813006223 catalytic residue [active] 813006224 prolyl-tRNA synthetase; Provisional; Region: PRK09194 813006225 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 813006226 dimer interface [polypeptide binding]; other site 813006227 motif 1; other site 813006228 active site 813006229 motif 2; other site 813006230 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 813006231 putative deacylase active site [active] 813006232 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813006233 active site 813006234 motif 3; other site 813006235 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 813006236 anticodon binding site; other site 813006237 GrpE; Region: GrpE; pfam01025 813006238 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 813006239 dimer interface [polypeptide binding]; other site 813006240 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 813006241 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 813006242 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 813006243 nucleotide binding site [chemical binding]; other site 813006244 NEF interaction site [polypeptide binding]; other site 813006245 SBD interface [polypeptide binding]; other site 813006246 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 813006247 Exoribonuclease R [Transcription]; Region: VacB; COG0557 813006248 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 813006249 RNB domain; Region: RNB; pfam00773 813006250 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 813006251 Putative zinc ribbon domain; Region: DUF164; pfam02591 813006252 KpsF/GutQ family protein; Region: kpsF; TIGR00393 813006253 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 813006254 putative active site [active] 813006255 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 813006256 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 813006257 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813006258 E3 interaction surface; other site 813006259 lipoyl attachment site [posttranslational modification]; other site 813006260 e3 binding domain; Region: E3_binding; pfam02817 813006261 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813006262 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 813006263 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 813006264 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 813006265 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 813006266 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 813006267 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 813006268 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 813006269 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 813006270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813006271 S-adenosylmethionine binding site [chemical binding]; other site 813006272 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 813006273 Lumazine binding domain; Region: Lum_binding; pfam00677 813006274 Lumazine binding domain; Region: Lum_binding; pfam00677 813006275 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 813006276 ATP cone domain; Region: ATP-cone; pfam03477 813006277 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 813006278 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 813006279 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 813006280 amino acid carrier protein; Region: agcS; TIGR00835 813006281 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 813006282 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 813006283 Predicted membrane protein [Function unknown]; Region: COG3952 813006284 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 813006285 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813006286 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813006287 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813006288 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813006289 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813006290 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813006291 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 813006292 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 813006293 intersubunit interface [polypeptide binding]; other site 813006294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813006295 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 813006296 Walker A/P-loop; other site 813006297 ATP binding site [chemical binding]; other site 813006298 Q-loop/lid; other site 813006299 ABC transporter signature motif; other site 813006300 Walker B; other site 813006301 D-loop; other site 813006302 H-loop/switch region; other site 813006303 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813006304 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813006305 ABC-ATPase subunit interface; other site 813006306 dimer interface [polypeptide binding]; other site 813006307 putative PBP binding regions; other site 813006308 GTPase CgtA; Reviewed; Region: obgE; PRK12299 813006309 GTP1/OBG; Region: GTP1_OBG; pfam01018 813006310 Obg GTPase; Region: Obg; cd01898 813006311 G1 box; other site 813006312 GTP/Mg2+ binding site [chemical binding]; other site 813006313 Switch I region; other site 813006314 G2 box; other site 813006315 G3 box; other site 813006316 Switch II region; other site 813006317 G4 box; other site 813006318 G5 box; other site 813006319 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 813006320 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 813006321 Uncharacterized conserved protein [Function unknown]; Region: COG2928 813006322 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 813006323 FOG: CBS domain [General function prediction only]; Region: COG0517 813006324 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813006325 Transporter associated domain; Region: CorC_HlyC; smart01091 813006326 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 813006327 anti sigma factor interaction site; other site 813006328 regulatory phosphorylation site [posttranslational modification]; other site 813006329 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 813006330 hypothetical protein; Provisional; Region: PRK05926 813006331 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813006332 FeS/SAM binding site; other site 813006333 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 813006334 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 813006335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813006336 S-adenosylmethionine binding site [chemical binding]; other site 813006337 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 813006338 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 813006339 diaminopimelate epimerase; Region: DapF; TIGR00652 813006340 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 813006341 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 813006342 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 813006343 homotrimer interaction site [polypeptide binding]; other site 813006344 zinc binding site [ion binding]; other site 813006345 CDP-binding sites; other site 813006346 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 813006347 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 813006348 FAD binding pocket [chemical binding]; other site 813006349 conserved FAD binding motif [chemical binding]; other site 813006350 phosphate binding motif [ion binding]; other site 813006351 beta-alpha-beta structure motif; other site 813006352 NAD binding pocket [chemical binding]; other site 813006353 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 813006354 elongation factor G; Reviewed; Region: PRK12739 813006355 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 813006356 G1 box; other site 813006357 putative GEF interaction site [polypeptide binding]; other site 813006358 GTP/Mg2+ binding site [chemical binding]; other site 813006359 Switch I region; other site 813006360 G2 box; other site 813006361 G3 box; other site 813006362 Switch II region; other site 813006363 G4 box; other site 813006364 G5 box; other site 813006365 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 813006366 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 813006367 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 813006368 30S ribosomal protein S7; Validated; Region: PRK05302 813006369 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 813006370 S17 interaction site [polypeptide binding]; other site 813006371 S8 interaction site; other site 813006372 16S rRNA interaction site [nucleotide binding]; other site 813006373 streptomycin interaction site [chemical binding]; other site 813006374 23S rRNA interaction site [nucleotide binding]; other site 813006375 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 813006376 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 813006377 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 813006378 protein binding site [polypeptide binding]; other site 813006379 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 813006380 Catalytic dyad [active] 813006381 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 813006382 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 813006383 Domain of unknown function DUF11; Region: DUF11; pfam01345 813006384 Domain of unknown function DUF11; Region: DUF11; pfam01345 813006385 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 813006386 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 813006387 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 813006388 HIGH motif; other site 813006389 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 813006390 active site 813006391 KMSKS motif; other site 813006392 Helix-turn-helix domain; Region: HTH_17; pfam12728 813006393 Helix-turn-helix domain; Region: HTH_17; pfam12728 813006394 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 813006395 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 813006396 Protein export membrane protein; Region: SecD_SecF; pfam02355 813006397 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 813006398 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 813006399 catalytic residue [active] 813006400 putative FPP diphosphate binding site; other site 813006401 putative FPP binding hydrophobic cleft; other site 813006402 dimer interface [polypeptide binding]; other site 813006403 putative IPP diphosphate binding site; other site 813006404 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 813006405 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 813006406 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 813006407 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 813006408 CMP-binding site; other site 813006409 The sites determining sugar specificity; other site 813006410 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 813006411 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 813006412 putative acyl-acceptor binding pocket; other site 813006413 arginine-tRNA ligase; Region: PLN02286 813006414 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 813006415 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 813006416 active site 813006417 HIGH motif; other site 813006418 KMSK motif region; other site 813006419 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813006420 tRNA binding surface [nucleotide binding]; other site 813006421 anticodon binding site; other site 813006422 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 813006423 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 813006424 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 813006425 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 813006426 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 813006427 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 813006428 Coenzyme A binding pocket [chemical binding]; other site 813006429 PCRF domain; Region: PCRF; pfam03462 813006430 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 813006431 RF-1 domain; Region: RF-1; pfam00472 813006432 SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531 813006433 SWI complex, BAF60b domains; Region: SWIB; smart00151 813006434 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 813006435 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813006436 putative active site [active] 813006437 putative metal binding site [ion binding]; other site 813006438 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 813006439 substrate binding site; other site 813006440 dimer interface; other site 813006441 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 813006442 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 813006443 dimerization interface 3.5A [polypeptide binding]; other site 813006444 active site 813006445 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 813006446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 813006447 active site 813006448 motif I; other site 813006449 motif II; other site 813006450 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 813006451 PAS domain; Region: PAS; smart00091 813006452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 813006453 dimer interface [polypeptide binding]; other site 813006454 phosphorylation site [posttranslational modification] 813006455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813006456 ATP binding site [chemical binding]; other site 813006457 Mg2+ binding site [ion binding]; other site 813006458 G-X-G motif; other site 813006459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 813006460 Response regulator receiver domain; Region: Response_reg; pfam00072 813006461 active site 813006462 phosphorylation site [posttranslational modification] 813006463 intermolecular recognition site; other site 813006464 dimerization interface [polypeptide binding]; other site 813006465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813006466 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 813006467 Walker A motif; other site 813006468 ATP binding site [chemical binding]; other site 813006469 Walker B motif; other site 813006470 arginine finger; other site 813006471 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 813006472 Recombination protein O N terminal; Region: RecO_N; pfam11967 813006473 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 813006474 Recombination protein O C terminal; Region: RecO_C; pfam02565 813006475 Uncharacterized conserved protein [Function unknown]; Region: COG1723 813006476 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 813006477 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 813006478 putative tRNA-binding site [nucleotide binding]; other site 813006479 B3/4 domain; Region: B3_4; pfam03483 813006480 tRNA synthetase B5 domain; Region: B5; smart00874 813006481 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 813006482 dimer interface [polypeptide binding]; other site 813006483 motif 1; other site 813006484 motif 3; other site 813006485 motif 2; other site 813006486 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 813006487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813006488 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 813006489 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 813006490 DNA binding site [nucleotide binding] 813006491 active site 813006492 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 813006493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813006494 dimer interface [polypeptide binding]; other site 813006495 conserved gate region; other site 813006496 putative PBP binding loops; other site 813006497 ABC-ATPase subunit interface; other site 813006498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 813006499 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 813006500 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 813006501 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 813006502 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 813006503 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 813006504 putative active site [active] 813006505 putative metal binding site [ion binding]; other site 813006506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813006507 binding surface 813006508 TPR motif; other site 813006509 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 813006510 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 813006511 C-terminal domain interface [polypeptide binding]; other site 813006512 active site 813006513 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 813006514 active site 813006515 N-terminal domain interface [polypeptide binding]; other site 813006516 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 813006517 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 813006518 substrate binding pocket [chemical binding]; other site 813006519 membrane-bound complex binding site; other site 813006520 hinge residues; other site 813006521 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 813006522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813006523 S-adenosylmethionine binding site [chemical binding]; other site 813006524 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 813006525 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813006526 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 813006527 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 813006528 ligand binding site; other site 813006529 oligomer interface; other site 813006530 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 813006531 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 813006532 N-terminal domain interface [polypeptide binding]; other site 813006533 sulfate 1 binding site; other site 813006534 transcription termination factor Rho; Region: rho; TIGR00767 813006535 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 813006536 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 813006537 RNA binding site [nucleotide binding]; other site 813006538 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 813006539 multimer interface [polypeptide binding]; other site 813006540 Walker A motif; other site 813006541 ATP binding site [chemical binding]; other site 813006542 Walker B motif; other site 813006543 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 813006544 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 813006545 CoA-binding site [chemical binding]; other site 813006546 ATP-binding [chemical binding]; other site 813006547 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 813006548 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 813006549 tandem repeat interface [polypeptide binding]; other site 813006550 oligomer interface [polypeptide binding]; other site 813006551 active site residues [active] 813006552 TLC ATP/ADP transporter; Region: TLC; pfam03219 813006553 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 813006554 replicative DNA helicase; Provisional; Region: PRK06321 813006555 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 813006556 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 813006557 Walker A motif; other site 813006558 ATP binding site [chemical binding]; other site 813006559 Walker B motif; other site 813006560 DNA binding loops [nucleotide binding] 813006561 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 813006562 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 813006563 RuvA N terminal domain; Region: RuvA_N; pfam01330 813006564 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 813006565 active site 813006566 putative DNA-binding cleft [nucleotide binding]; other site 813006567 dimer interface [polypeptide binding]; other site 813006568 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 813006569 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 813006570 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 813006571 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 813006572 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 813006573 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 813006574 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 813006575 alphaNTD - beta interaction site [polypeptide binding]; other site 813006576 alphaNTD homodimer interface [polypeptide binding]; other site 813006577 alphaNTD - beta' interaction site [polypeptide binding]; other site 813006578 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 813006579 30S ribosomal protein S11; Validated; Region: PRK05309 813006580 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 813006581 30S ribosomal protein S13; Region: bact_S13; TIGR03631 813006582 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 813006583 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 813006584 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 813006585 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 813006586 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 813006587 5S rRNA interface [nucleotide binding]; other site 813006588 23S rRNA interface [nucleotide binding]; other site 813006589 L5 interface [polypeptide binding]; other site 813006590 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 813006591 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 813006592 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 813006593 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 813006594 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 813006595 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 813006596 RNA binding site [nucleotide binding]; other site 813006597 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 813006598 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 813006599 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 813006600 23S rRNA interface [nucleotide binding]; other site 813006601 putative translocon interaction site; other site 813006602 signal recognition particle (SRP54) interaction site; other site 813006603 L23 interface [polypeptide binding]; other site 813006604 trigger factor interaction site; other site 813006605 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 813006606 23S rRNA interface [nucleotide binding]; other site 813006607 5S rRNA interface [nucleotide binding]; other site 813006608 putative antibiotic binding site [chemical binding]; other site 813006609 L25 interface [polypeptide binding]; other site 813006610 L27 interface [polypeptide binding]; other site 813006611 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 813006612 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 813006613 G-X-X-G motif; other site 813006614 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 813006615 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 813006616 putative translocon binding site; other site 813006617 protein-rRNA interface [nucleotide binding]; other site 813006618 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 813006619 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 813006620 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 813006621 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 813006622 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 813006623 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 813006624 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 813006625 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 813006626 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 813006627 putative active site [active] 813006628 substrate binding site [chemical binding]; other site 813006629 putative cosubstrate binding site; other site 813006630 catalytic site [active] 813006631 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 813006632 substrate binding site [chemical binding]; other site 813006633 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 813006634 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 813006635 active site 813006636 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 813006637 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 813006638 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 813006639 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 813006640 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 813006641 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 813006642 active site 813006643 catalytic site [active] 813006644 substrate binding site [chemical binding]; other site 813006645 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 813006646 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 813006647 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 813006648 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 813006649 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813006650 catalytic residues [active] 813006651 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 813006652 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 813006653 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 813006654 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 813006655 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 813006656 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 813006657 dimer interface [polypeptide binding]; other site 813006658 anticodon binding site; other site 813006659 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 813006660 homodimer interface [polypeptide binding]; other site 813006661 motif 1; other site 813006662 active site 813006663 motif 2; other site 813006664 GAD domain; Region: GAD; pfam02938 813006665 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813006666 active site 813006667 motif 3; other site 813006668 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 813006669 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 813006670 dimer interface [polypeptide binding]; other site 813006671 motif 1; other site 813006672 active site 813006673 motif 2; other site 813006674 motif 3; other site 813006675 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 813006676 anticodon binding site; other site 813006677 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 813006678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813006679 putative substrate translocation pore; other site 813006680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813006681 TPR repeat; Region: TPR_11; pfam13414 813006682 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813006683 binding surface 813006684 TPR motif; other site 813006685 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 813006686 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 813006687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 813006688 Mg2+ binding site [ion binding]; other site 813006689 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 813006690 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 813006691 branched-chain amino acid uptake carrier; Region: livcs; TIGR00796 813006692 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 813006693 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813006694 ATP binding site [chemical binding]; other site 813006695 putative Mg++ binding site [ion binding]; other site 813006696 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813006697 ATP-binding site [chemical binding]; other site 813006698 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 813006699 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 813006700 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 813006701 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 813006702 lipoate synthase; Region: lipA; TIGR00510 813006703 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813006704 FeS/SAM binding site; other site 813006705 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 813006706 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 813006707 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 813006708 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 813006709 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 813006710 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 813006711 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 813006712 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 813006713 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 813006714 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 813006715 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 813006716 Walker A motif; other site 813006717 ATP binding site [chemical binding]; other site 813006718 Walker B motif; other site 813006719 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 813006720 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813006721 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 813006722 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 813006723 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 813006724 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 813006725 active site 813006726 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 813006727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813006728 ATP binding site [chemical binding]; other site 813006729 Mg2+ binding site [ion binding]; other site 813006730 G-X-G motif; other site 813006731 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 813006732 ATP binding site [chemical binding]; other site 813006733 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 813006734 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 813006735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813006736 binding surface 813006737 TPR motif; other site 813006738 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 813006739 EamA-like transporter family; Region: EamA; pfam00892 813006740 EamA-like transporter family; Region: EamA; pfam00892 813006741 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 813006742 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 813006743 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 813006744 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 813006745 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 813006746 active site 813006747 HIGH motif; other site 813006748 dimer interface [polypeptide binding]; other site 813006749 KMSKS motif; other site 813006750 excinuclease ABC subunit B; Provisional; Region: PRK05298 813006751 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813006752 ATP binding site [chemical binding]; other site 813006753 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813006754 nucleotide binding region [chemical binding]; other site 813006755 ATP-binding site [chemical binding]; other site 813006756 Ultra-violet resistance protein B; Region: UvrB; pfam12344 813006757 enolase; Provisional; Region: eno; PRK00077 813006758 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 813006759 dimer interface [polypeptide binding]; other site 813006760 metal binding site [ion binding]; metal-binding site 813006761 substrate binding pocket [chemical binding]; other site 813006762 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 813006763 HAMP domain; Region: HAMP; pfam00672 813006764 dimerization interface [polypeptide binding]; other site 813006765 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 813006766 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 813006767 Iron-sulfur protein interface; other site 813006768 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 813006769 proximal heme binding site [chemical binding]; other site 813006770 Iron-sulfur protein interface; other site 813006771 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 813006772 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 813006773 active site 813006774 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 813006775 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 813006776 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 813006777 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 813006778 ligand binding site [chemical binding]; other site 813006779 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 813006780 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813006781 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 813006782 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 813006783 dimer interface [polypeptide binding]; other site 813006784 decamer (pentamer of dimers) interface [polypeptide binding]; other site 813006785 catalytic triad [active] 813006786 peroxidatic and resolving cysteines [active] 813006787 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 813006788 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 813006789 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 813006790 ligand binding site [chemical binding]; other site 813006791 active site 813006792 UGI interface [polypeptide binding]; other site 813006793 catalytic site [active] 813006794 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 813006795 Part of AAA domain; Region: AAA_19; pfam13245 813006796 Family description; Region: UvrD_C_2; pfam13538 813006797 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 813006798 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 813006799 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 813006800 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 813006801 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 813006802 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 813006803 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 813006804 folate binding site [chemical binding]; other site 813006805 NADP+ binding site [chemical binding]; other site 813006806 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 813006807 catalytic center binding site [active] 813006808 ATP binding site [chemical binding]; other site 813006809 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 813006810 dihydropteroate synthase; Region: DHPS; TIGR01496 813006811 substrate binding pocket [chemical binding]; other site 813006812 dimer interface [polypeptide binding]; other site 813006813 inhibitor binding site; inhibition site 813006814 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 813006815 homooctamer interface [polypeptide binding]; other site 813006816 active site 813006817 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 813006818 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 813006819 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 813006820 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 813006821 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 813006822 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 813006823 DNA binding residues [nucleotide binding] 813006824 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 813006825 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 813006826 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 813006827 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 813006828 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813006829 RNA binding surface [nucleotide binding]; other site 813006830 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 813006831 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 813006832 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 813006833 active site 813006834 interdomain interaction site; other site 813006835 putative metal-binding site [ion binding]; other site 813006836 nucleotide binding site [chemical binding]; other site 813006837 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 813006838 domain I; other site 813006839 DNA binding groove [nucleotide binding] 813006840 phosphate binding site [ion binding]; other site 813006841 domain II; other site 813006842 domain III; other site 813006843 nucleotide binding site [chemical binding]; other site 813006844 catalytic site [active] 813006845 domain IV; other site 813006846 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813006847 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813006848 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813006849 SWI complex, BAF60b domains; Region: SWIB; smart00151 813006850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813006851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813006852 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 813006853 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 813006854 recombinase A; Provisional; Region: recA; PRK09354 813006855 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 813006856 hexamer interface [polypeptide binding]; other site 813006857 Walker A motif; other site 813006858 ATP binding site [chemical binding]; other site 813006859 Walker B motif; other site 813006860 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 813006861 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 813006862 AAA domain; Region: AAA_30; pfam13604 813006863 Family description; Region: UvrD_C_2; pfam13538 813006864 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 813006865 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 813006866 Walker A/P-loop; other site 813006867 ATP binding site [chemical binding]; other site 813006868 Q-loop/lid; other site 813006869 ABC transporter signature motif; other site 813006870 Walker B; other site 813006871 D-loop; other site 813006872 H-loop/switch region; other site 813006873 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 813006874 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 813006875 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 813006876 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 813006877 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813006878 RNA binding surface [nucleotide binding]; other site 813006879 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 813006880 active site 813006881 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 813006882 DNA Topoisomerase IV; Region: TOP4c; smart00434 813006883 CAP-like domain; other site 813006884 active site 813006885 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 813006886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813006887 ATP binding site [chemical binding]; other site 813006888 Mg2+ binding site [ion binding]; other site 813006889 G-X-G motif; other site 813006890 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 813006891 ATP binding site [chemical binding]; other site 813006892 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 813006893 active site 813006894 putative metal-binding site [ion binding]; other site 813006895 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 813006896 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 813006897 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 813006898 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813006899 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 813006900 phosphopeptide binding site; other site 813006901 MARCKS family; Region: MARCKS; pfam02063 813006902 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 813006903 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 813006904 phosphopeptide binding site; other site 813006905 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 813006906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 813006907 binding surface 813006908 Tetratricopeptide repeat; Region: TPR_16; pfam13432 813006909 TPR motif; other site 813006910 type III secretion system ATPase; Provisional; Region: PRK06315 813006911 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813006912 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 813006913 Walker A motif/ATP binding site; other site 813006914 Walker B motif; other site 813006915 type III secretion system protein; Validated; Region: PRK05933 813006916 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 813006917 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 813006918 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813006919 active site 813006920 ATP binding site [chemical binding]; other site 813006921 substrate binding site [chemical binding]; other site 813006922 activation loop (A-loop); other site 813006923 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 813006924 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813006925 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813006926 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 813006927 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 813006928 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 813006929 ADP binding site [chemical binding]; other site 813006930 phosphagen binding site; other site 813006931 substrate specificity loop; other site 813006932 ribosome recycling factor; Reviewed; Region: frr; PRK00083 813006933 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 813006934 hinge region; other site 813006935 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 813006936 putative nucleotide binding site [chemical binding]; other site 813006937 uridine monophosphate binding site [chemical binding]; other site 813006938 homohexameric interface [polypeptide binding]; other site 813006939 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 813006940 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 813006941 Elongation factor TS; Region: EF_TS; pfam00889 813006942 Elongation factor TS; Region: EF_TS; pfam00889 813006943 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 813006944 rRNA interaction site [nucleotide binding]; other site 813006945 S8 interaction site; other site 813006946 putative laminin-1 binding site; other site 813006947 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 813006948 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 813006949 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 813006950 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 813006951 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 813006952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813006953 TPR motif; other site 813006954 Tetratricopeptide repeat; Region: TPR_16; pfam13432 813006955 binding surface 813006956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813006957 binding surface 813006958 TPR motif; other site 813006959 TPR repeat; Region: TPR_11; pfam13414 813006960 TPR repeat; Region: TPR_11; pfam13414 813006961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813006962 binding surface 813006963 TPR motif; other site 813006964 TPR repeat; Region: TPR_11; pfam13414 813006965 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 813006966 putative ABC transporter; Region: ycf24; CHL00085 813006967 FeS assembly ATPase SufC; Region: sufC; TIGR01978 813006968 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 813006969 Walker A/P-loop; other site 813006970 ATP binding site [chemical binding]; other site 813006971 Q-loop/lid; other site 813006972 ABC transporter signature motif; other site 813006973 Walker B; other site 813006974 D-loop; other site 813006975 H-loop/switch region; other site 813006976 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 813006977 FeS assembly protein SufD; Region: sufD; TIGR01981 813006978 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 813006979 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 813006980 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813006981 catalytic residue [active] 813006982 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 813006983 ParB-like nuclease domain; Region: ParBc; pfam02195 813006984 KorB domain; Region: KorB; pfam08535 813006985 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813006986 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 813006987 Walker A/P-loop; other site 813006988 ATP binding site [chemical binding]; other site 813006989 Q-loop/lid; other site 813006990 ABC transporter signature motif; other site 813006991 Walker B; other site 813006992 D-loop; other site 813006993 H-loop/switch region; other site 813006994 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813006995 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 813006996 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813006997 Walker A/P-loop; other site 813006998 ATP binding site [chemical binding]; other site 813006999 Q-loop/lid; other site 813007000 ABC transporter signature motif; other site 813007001 Walker B; other site 813007002 D-loop; other site 813007003 H-loop/switch region; other site 813007004 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813007005 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 813007006 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 813007007 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 813007008 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 813007009 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 813007010 minor groove reading motif; other site 813007011 helix-hairpin-helix signature motif; other site 813007012 substrate binding pocket [chemical binding]; other site 813007013 active site 813007014 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 813007015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813007016 binding surface 813007017 TPR motif; other site 813007018 Predicted GTPases [General function prediction only]; Region: COG1160 813007019 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 813007020 G1 box; other site 813007021 GTP/Mg2+ binding site [chemical binding]; other site 813007022 Switch I region; other site 813007023 G2 box; other site 813007024 Switch II region; other site 813007025 G3 box; other site 813007026 G4 box; other site 813007027 G5 box; other site 813007028 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 813007029 G1 box; other site 813007030 GTP/Mg2+ binding site [chemical binding]; other site 813007031 Switch I region; other site 813007032 G2 box; other site 813007033 G3 box; other site 813007034 Switch II region; other site 813007035 G4 box; other site 813007036 G5 box; other site 813007037 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 813007038 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 813007039 active site 813007040 NTP binding site [chemical binding]; other site 813007041 metal binding triad [ion binding]; metal-binding site 813007042 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 813007043 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 813007044 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 813007045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813007046 Walker A motif; other site 813007047 ATP binding site [chemical binding]; other site 813007048 Walker B motif; other site 813007049 arginine finger; other site 813007050 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 813007051 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 813007052 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 813007053 oligomer interface [polypeptide binding]; other site 813007054 active site residues [active] 813007055 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 813007056 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 813007057 rod shape-determining protein MreB; Provisional; Region: PRK13927 813007058 MreB and similar proteins; Region: MreB_like; cd10225 813007059 nucleotide binding site [chemical binding]; other site 813007060 Mg binding site [ion binding]; other site 813007061 putative protofilament interaction site [polypeptide binding]; other site 813007062 RodZ interaction site [polypeptide binding]; other site 813007063 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 813007064 active site 813007065 substrate-binding site [chemical binding]; other site 813007066 metal-binding site [ion binding] 813007067 GTP binding site [chemical binding]; other site 813007068 Effector from type III secretion system; Region: Effector_1; pfam04518 813007069 Effector from type III secretion system; Region: Effector_1; pfam04518 813007070 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 813007071 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 813007072 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 813007073 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 813007074 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 813007075 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 813007076 active site 813007077 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 813007078 type III secretion system ATPase; Validated; Region: PRK05922 813007079 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813007080 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 813007081 Walker A motif; other site 813007082 ATP binding site [chemical binding]; other site 813007083 Walker B motif; other site 813007084 type III secretion system protein; Validated; Region: PRK05934 813007085 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 813007086 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 813007087 active site 813007088 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 813007089 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 813007090 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813007091 catalytic residue [active] 813007092 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 813007093 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813007094 RNA binding surface [nucleotide binding]; other site 813007095 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 813007096 active site 813007097 biotin--protein ligase; Provisional; Region: PRK05935 813007098 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 813007099 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 813007100 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 813007101 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 813007102 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 813007103 motif II; other site 813007104 CCC1-related protein family; Region: CCC1_like_1; cd02437 813007105 seryl-tRNA synthetase; Provisional; Region: PRK05431 813007106 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 813007107 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 813007108 dimer interface [polypeptide binding]; other site 813007109 active site 813007110 motif 1; other site 813007111 motif 2; other site 813007112 motif 3; other site 813007113 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 813007114 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 813007115 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 813007116 dimerization interface [polypeptide binding]; other site 813007117 active site 813007118 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 813007119 homopentamer interface [polypeptide binding]; other site 813007120 active site 813007121 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 813007122 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 813007123 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 813007124 substrate binding site [chemical binding]; other site 813007125 Proteins containing SET domain [General function prediction only]; Region: COG2940 813007126 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 813007127 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 813007128 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 813007129 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 813007130 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 813007131 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 813007132 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 813007133 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 813007134 catalytic loop [active] 813007135 iron binding site [ion binding]; other site 813007136 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 813007137 FAD binding pocket [chemical binding]; other site 813007138 FAD binding motif [chemical binding]; other site 813007139 phosphate binding motif [ion binding]; other site 813007140 beta-alpha-beta structure motif; other site 813007141 NAD binding pocket [chemical binding]; other site 813007142 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 813007143 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 813007144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813007145 S-adenosylmethionine binding site [chemical binding]; other site 813007146 Histone H1-like protein Hc1; Region: Hc1; pfam07432 813007147 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 813007148 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 813007149 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 813007150 HemN C-terminal domain; Region: HemN_C; pfam06969 813007151 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 813007152 substrate binding site [chemical binding]; other site 813007153 active site 813007154 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 813007155 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 813007156 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813007157 ATP binding site [chemical binding]; other site 813007158 putative Mg++ binding site [ion binding]; other site 813007159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813007160 nucleotide binding region [chemical binding]; other site 813007161 ATP-binding site [chemical binding]; other site 813007162 TRCF domain; Region: TRCF; pfam03461 813007163 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 813007164 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 813007165 motif 1; other site 813007166 active site 813007167 motif 2; other site 813007168 motif 3; other site 813007169 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 813007170 DHHA1 domain; Region: DHHA1; pfam02272 813007171 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 813007172 elongation factor P; Validated; Region: PRK00529 813007173 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 813007174 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 813007175 RNA binding site [nucleotide binding]; other site 813007176 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 813007177 RNA binding site [nucleotide binding]; other site 813007178 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813007179 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 813007180 putative active site [active] 813007181 putative metal binding site [ion binding]; other site 813007182 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 813007183 active site 813007184 metal binding site [ion binding]; metal-binding site 813007185 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 813007186 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 813007187 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 813007188 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813007189 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813007190 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 813007191 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 813007192 Mg++ binding site [ion binding]; other site 813007193 putative catalytic motif [active] 813007194 putative substrate binding site [chemical binding]; other site 813007195 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 813007196 TrkA-N domain; Region: TrkA_N; pfam02254 813007197 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813007198 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813007199 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 813007200 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813007201 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813007202 cell division protein FtsW; Region: ftsW; TIGR02614 813007203 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 813007204 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 813007205 active site 813007206 homodimer interface [polypeptide binding]; other site 813007207 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 813007208 anti sigma factor interaction site; other site 813007209 regulatory phosphorylation site [posttranslational modification]; other site 813007210 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 813007211 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 813007212 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813007213 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 813007214 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 813007215 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 813007216 dimer interface [polypeptide binding]; other site 813007217 active site 813007218 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 813007219 active site 813007220 Ap4A binding cleft/pocket [chemical binding]; other site 813007221 P4 phosphate binding site; other site 813007222 nudix motif; other site 813007223 putative P2/P3 phosphate binding site [ion binding]; other site 813007224 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 813007225 dimer interface [polypeptide binding]; other site 813007226 substrate binding site [chemical binding]; other site 813007227 metal binding sites [ion binding]; metal-binding site 813007228 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 813007229 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 813007230 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 813007231 NAD binding site [chemical binding]; other site 813007232 Phe binding site; other site 813007233 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 813007234 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 813007235 active site 813007236 putative lithium-binding site [ion binding]; other site 813007237 substrate binding site [chemical binding]; other site 813007238 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 813007239 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 813007240 putative acyl-acceptor binding pocket; other site 813007241 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 813007242 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 813007243 acyl-activating enzyme (AAE) consensus motif; other site 813007244 AMP binding site [chemical binding]; other site 813007245 active site 813007246 CoA binding site [chemical binding]; other site 813007247 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 813007248 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813007249 ATP binding site [chemical binding]; other site 813007250 putative Mg++ binding site [ion binding]; other site 813007251 helicase superfamily c-terminal domain; Region: HELICc; smart00490 813007252 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 813007253 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813007254 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 813007255 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 813007256 active site 813007257 HIGH motif; other site 813007258 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 813007259 KMSKS motif; other site 813007260 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813007261 tRNA binding surface [nucleotide binding]; other site 813007262 anticodon binding site; other site 813007263 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 813007264 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813007265 ribonuclease P; Reviewed; Region: rnpA; PRK00730 813007266 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 813007267 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 813007268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 813007269 DNA primase; Validated; Region: dnaG; PRK05667 813007270 CHC2 zinc finger; Region: zf-CHC2; pfam01807 813007271 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 813007272 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 813007273 active site 813007274 metal binding site [ion binding]; metal-binding site 813007275 interdomain interaction site; other site 813007276 glycyl-tRNA synthetase; Provisional; Region: PRK14908 813007277 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 813007278 dimer interface [polypeptide binding]; other site 813007279 motif 1; other site 813007280 active site 813007281 motif 2; other site 813007282 motif 3; other site 813007283 DALR anticodon binding domain; Region: DALR_1; pfam05746 813007284 glycogen synthase; Provisional; Region: glgA; PRK00654 813007285 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 813007286 ADP-binding pocket [chemical binding]; other site 813007287 homodimer interface [polypeptide binding]; other site 813007288 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 813007289 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 813007290 5S rRNA interface [nucleotide binding]; other site 813007291 CTC domain interface [polypeptide binding]; other site 813007292 L16 interface [polypeptide binding]; other site 813007293 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 813007294 putative active site [active] 813007295 catalytic residue [active] 813007296 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 813007297 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 813007298 Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359 813007299 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 813007300 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 813007301 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 813007302 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 813007303 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 813007304 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813007305 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813007306 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 813007307 putative acyl-acceptor binding pocket; other site 813007308 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 813007309 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 813007310 homodimer interface [polypeptide binding]; other site 813007311 oligonucleotide binding site [chemical binding]; other site 813007312 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 813007313 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 813007314 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813007315 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813007316 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 813007317 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 813007318 active site 813007319 substrate binding site [chemical binding]; other site 813007320 metal binding site [ion binding]; metal-binding site 813007321 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 813007322 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 813007323 glutaminase active site [active] 813007324 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 813007325 dimer interface [polypeptide binding]; other site 813007326 active site 813007327 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 813007328 dimer interface [polypeptide binding]; other site 813007329 active site 813007330 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 813007331 aromatic amino acid transport protein; Region: araaP; TIGR00837 813007332 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 813007333 aromatic amino acid transport protein; Region: araaP; TIGR00837 813007334 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 813007335 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 813007336 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 813007337 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 813007338 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 813007339 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 813007340 CoA-ligase; Region: Ligase_CoA; pfam00549 813007341 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 813007342 CoA binding domain; Region: CoA_binding; smart00881 813007343 CoA-ligase; Region: Ligase_CoA; pfam00549 813007344 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 813007345 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 813007346 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 813007347 protein binding site [polypeptide binding]; other site 813007348 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 813007349 protein binding site [polypeptide binding]; other site 813007350 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 813007351 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 813007352 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813007353 Peptidase M16C associated; Region: M16C_assoc; pfam08367 813007354 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813007355 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 813007356 RmuC family; Region: RmuC; pfam02646 813007357 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 813007358 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 813007359 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 813007360 dimer interface [polypeptide binding]; other site 813007361 putative radical transfer pathway; other site 813007362 diiron center [ion binding]; other site 813007363 tyrosyl radical; other site 813007364 Putative methyltransferase; Region: Methyltransf_4; pfam02390 813007365 Methyltransferase domain; Region: Methyltransf_18; pfam12847 813007366 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 813007367 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 813007368 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 813007369 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 813007370 Ribosomal protein L35 [Translation, ribosomal structure and biogenesis]; Region: RpmI; COG0291 813007371 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 813007372 23S rRNA binding site [nucleotide binding]; other site 813007373 L21 binding site [polypeptide binding]; other site 813007374 L13 binding site [polypeptide binding]; other site 813007375 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 813007376 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 813007377 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 813007378 motif 1; other site 813007379 dimer interface [polypeptide binding]; other site 813007380 active site 813007381 motif 2; other site 813007382 motif 3; other site 813007383 Predicted permeases [General function prediction only]; Region: COG0795 813007384 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 813007385 Predicted permeases [General function prediction only]; Region: COG0795 813007386 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 813007387 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 813007388 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 813007389 Ligand Binding Site [chemical binding]; other site 813007390 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 813007391 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 813007392 RNase E interface [polypeptide binding]; other site 813007393 trimer interface [polypeptide binding]; other site 813007394 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 813007395 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 813007396 RNase E interface [polypeptide binding]; other site 813007397 trimer interface [polypeptide binding]; other site 813007398 active site 813007399 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 813007400 putative nucleic acid binding region [nucleotide binding]; other site 813007401 G-X-X-G motif; other site 813007402 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 813007403 RNA binding site [nucleotide binding]; other site 813007404 domain interface; other site 813007405 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 813007406 16S/18S rRNA binding site [nucleotide binding]; other site 813007407 S13e-L30e interaction site [polypeptide binding]; other site 813007408 25S rRNA binding site [nucleotide binding]; other site 813007409 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 813007410 nucleoside/Zn binding site; other site 813007411 dimer interface [polypeptide binding]; other site 813007412 catalytic motif [active] 813007413 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813007414 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813007415 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813007416 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813007417 methionine aminopeptidase; Provisional; Region: PRK12318 813007418 SEC-C motif; Region: SEC-C; pfam02810 813007419 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 813007420 active site 813007421 MarC family integral membrane protein; Region: MarC; pfam01914 813007422 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 813007423 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 813007424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813007425 dimer interface [polypeptide binding]; other site 813007426 conserved gate region; other site 813007427 putative PBP binding loops; other site 813007428 ABC-ATPase subunit interface; other site 813007429 NMT1/THI5 like; Region: NMT1; pfam09084 813007430 high affinity sulphate transporter 1; Region: sulP; TIGR00815 813007431 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 813007432 Sulfate transporter family; Region: Sulfate_transp; pfam00916 813007433 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 813007434 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 813007435 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 813007436 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 813007437 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 813007438 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 813007439 active site triad [active] 813007440 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 813007441 LytB protein; Region: LYTB; pfam02401 813007442 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 813007443 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 813007444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 813007445 binding surface 813007446 TPR motif; other site 813007447 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 813007448 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 813007449 active site 813007450 DNA binding site [nucleotide binding] 813007451 Int/Topo IB signature motif; other site 813007452 glycogen branching enzyme; Provisional; Region: PRK05402 813007453 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 813007454 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 813007455 active site 813007456 catalytic site [active] 813007457 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 813007458 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 813007459 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 813007460 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813007461 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813007462 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813007463 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813007464 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813007465 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813007466 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813007467 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813007468 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813007469 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813007470 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813007471 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813007472 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813007473 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813007474 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813007475 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813007476 Uncharacterized conserved protein [Function unknown]; Region: COG2155 813007477 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 813007478 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 813007479 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 813007480 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 813007481 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 813007482 GatB domain; Region: GatB_Yqey; pfam02637 813007483 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 813007484 ribonuclease HIII; Region: rnhC; TIGR00716 813007485 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 813007486 RNA/DNA hybrid binding site [nucleotide binding]; other site 813007487 active site 813007488 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 813007489 Helix-turn-helix domain; Region: HTH_25; pfam13413 813007490 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906 813007491 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 813007492 putative acyl-acceptor binding pocket; other site 813007493 Uncharacterized conserved protein [Function unknown]; Region: COG1624 813007494 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 813007495 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 813007496 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 813007497 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 813007498 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 813007499 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 813007500 putative active site [active] 813007501 PhoH-like protein; Region: PhoH; pfam02562 813007502 Bacterial SH3 domain homologues; Region: SH3b; smart00287 813007503 Bacterial SH3 domain homologues; Region: SH3b; smart00287 813007504 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 813007505 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 813007506 HIGH motif; other site 813007507 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 813007508 active site 813007509 KMSKS motif; other site 813007510 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 813007511 tRNA binding surface [nucleotide binding]; other site 813007512 anticodon binding site; other site 813007513 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 813007514 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 813007515 Catalytic site [active] 813007516 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 813007517 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 813007518 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 813007519 peptide chain release factor 1; Validated; Region: prfA; PRK00591 813007520 PCRF domain; Region: PCRF; pfam03462 813007521 RF-1 domain; Region: RF-1; pfam00472 813007522 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 813007523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813007524 S-adenosylmethionine binding site [chemical binding]; other site 813007525 signal recognition particle protein; Provisional; Region: PRK10867 813007526 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 813007527 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 813007528 P loop; other site 813007529 GTP binding site [chemical binding]; other site 813007530 Signal peptide binding domain; Region: SRP_SPB; pfam02978 813007531 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 813007532 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 813007533 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 813007534 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 813007535 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 813007536 RNA/DNA hybrid binding site [nucleotide binding]; other site 813007537 active site 813007538 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 813007539 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 813007540 catalytic site [active] 813007541 G-X2-G-X-G-K; other site 813007542 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 813007543 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 813007544 active site 813007545 HIGH motif; other site 813007546 KMSKS motif; other site 813007547 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 813007548 tRNA binding surface [nucleotide binding]; other site 813007549 anticodon binding site; other site 813007550 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 813007551 AAA domain; Region: AAA_30; pfam13604 813007552 Family description; Region: UvrD_C_2; pfam13538 813007553 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 813007554 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 813007555 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 813007556 conserved cys residue [active] 813007557 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 813007558 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 813007559 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 813007560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813007561 Walker A motif; other site 813007562 ATP binding site [chemical binding]; other site 813007563 Walker B motif; other site 813007564 arginine finger; other site 813007565 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 813007566 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 813007567 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 813007568 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 813007569 active site 813007570 catalytic site [active] 813007571 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813007572 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 813007573 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 813007574 dimer interface [polypeptide binding]; other site 813007575 ssDNA binding site [nucleotide binding]; other site 813007576 tetramer (dimer of dimers) interface [polypeptide binding]; other site 813007577 multifunctional aminopeptidase A; Provisional; Region: PRK00913 813007578 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 813007579 interface (dimer of trimers) [polypeptide binding]; other site 813007580 Substrate-binding/catalytic site; other site 813007581 Zn-binding sites [ion binding]; other site 813007582 hypothetical protein; Provisional; Region: PRK05907 813007583 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 813007584 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813007585 FeS/SAM binding site; other site 813007586 HemN C-terminal domain; Region: HemN_C; pfam06969 813007587 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 813007588 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 813007589 TPP-binding site [chemical binding]; other site 813007590 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 813007591 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 813007592 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813007593 E3 interaction surface; other site 813007594 lipoyl attachment site [posttranslational modification]; other site 813007595 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813007596 IncA protein; Region: IncA; pfam04156 813007597 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 813007598 ADP-ribose binding site [chemical binding]; other site 813007599 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 813007600 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 813007601 catalytic loop [active] 813007602 iron binding site [ion binding]; other site 813007603 type III secretion system protein; Validated; Region: PRK05910 813007604 FHIPEP family; Region: FHIPEP; pfam00771 813007605 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 813007606 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 813007607 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 813007608 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 813007609 DNA binding residues [nucleotide binding] 813007610 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 813007611 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 813007612 active site 813007613 HIGH motif; other site 813007614 dimer interface [polypeptide binding]; other site 813007615 KMSKS motif; other site 813007616 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813007617 RNA binding surface [nucleotide binding]; other site 813007618 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 813007619 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 813007620 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 813007621 GTP-binding protein LepA; Provisional; Region: PRK05433 813007622 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 813007623 G1 box; other site 813007624 putative GEF interaction site [polypeptide binding]; other site 813007625 GTP/Mg2+ binding site [chemical binding]; other site 813007626 Switch I region; other site 813007627 G2 box; other site 813007628 G3 box; other site 813007629 Switch II region; other site 813007630 G4 box; other site 813007631 G5 box; other site 813007632 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 813007633 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 813007634 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 813007635 ADP/ATP carrier protein family; Region: AAA; TIGR00769 813007636 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 813007637 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 813007638 intersubunit interface [polypeptide binding]; other site 813007639 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 813007640 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 813007641 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813007642 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813007643 ABC-ATPase subunit interface; other site 813007644 dimer interface [polypeptide binding]; other site 813007645 putative PBP binding regions; other site 813007646 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 813007647 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 813007648 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813007649 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813007650 ABC-ATPase subunit interface; other site 813007651 dimer interface [polypeptide binding]; other site 813007652 putative PBP binding regions; other site 813007653 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 813007654 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 813007655 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 813007656 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 813007657 RIP metalloprotease RseP; Region: TIGR00054 813007658 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 813007659 active site 813007660 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 813007661 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 813007662 putative substrate binding region [chemical binding]; other site 813007663 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 813007664 Putative serine esterase (DUF676); Region: DUF676; pfam05057 813007665 recF protein; Region: recf; TIGR00611 813007666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813007667 Walker A/P-loop; other site 813007668 ATP binding site [chemical binding]; other site 813007669 Q-loop/lid; other site 813007670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813007671 ABC transporter signature motif; other site 813007672 Walker B; other site 813007673 DNA polymerase III subunit beta; Validated; Region: PRK05643 813007674 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 813007675 putative DNA binding surface [nucleotide binding]; other site 813007676 dimer interface [polypeptide binding]; other site 813007677 beta-clamp/clamp loader binding surface; other site 813007678 beta-clamp/translesion DNA polymerase binding surface; other site 813007679 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 813007680 SmpB-tmRNA interface; other site 813007681 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 813007682 ApbE family; Region: ApbE; pfam02424 813007683 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813007684 PLD-like domain; Region: PLDc_2; pfam13091 813007685 putative active site [active] 813007686 catalytic site [active] 813007687 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813007688 PLD-like domain; Region: PLDc_2; pfam13091 813007689 putative active site [active] 813007690 catalytic site [active] 813007691 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 813007692 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813007693 HrpJ-like domain; Region: HrpJ; cl15454 813007694 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 813007695 FHIPEP family; Region: FHIPEP; pfam00771 813007696 type III secretion system protein; Validated; Region: PRK06298 813007697 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 813007698 GTP-binding protein YchF; Reviewed; Region: PRK09601 813007699 YchF GTPase; Region: YchF; cd01900 813007700 G1 box; other site 813007701 GTP/Mg2+ binding site [chemical binding]; other site 813007702 Switch I region; other site 813007703 G2 box; other site 813007704 Switch II region; other site 813007705 G3 box; other site 813007706 G4 box; other site 813007707 G5 box; other site 813007708 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 813007709 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 813007710 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 813007711 active site 813007712 Riboflavin kinase; Region: Flavokinase; smart00904 813007713 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 813007714 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 813007715 RNA binding site [nucleotide binding]; other site 813007716 active site 813007717 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 813007718 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 813007719 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 813007720 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 813007721 G1 box; other site 813007722 putative GEF interaction site [polypeptide binding]; other site 813007723 GTP/Mg2+ binding site [chemical binding]; other site 813007724 Switch I region; other site 813007725 G2 box; other site 813007726 G3 box; other site 813007727 Switch II region; other site 813007728 G4 box; other site 813007729 G5 box; other site 813007730 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 813007731 Translation-initiation factor 2; Region: IF-2; pfam11987 813007732 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 813007733 transcription termination factor NusA; Region: NusA; TIGR01953 813007734 NusA N-terminal domain; Region: NusA_N; pfam08529 813007735 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 813007736 RNA binding site [nucleotide binding]; other site 813007737 homodimer interface [polypeptide binding]; other site 813007738 NusA-like KH domain; Region: KH_5; pfam13184 813007739 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 813007740 G-X-X-G motif; other site 813007741 ribosomal protein S1; Region: rpsA; TIGR00717 813007742 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 813007743 RNA binding site [nucleotide binding]; other site 813007744 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 813007745 RNA binding site [nucleotide binding]; other site 813007746 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813007747 RNA binding site [nucleotide binding]; other site 813007748 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813007749 RNA binding site [nucleotide binding]; other site 813007750 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 813007751 RNA binding site [nucleotide binding]; other site 813007752 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 813007753 RNA binding site [nucleotide binding]; other site 813007754 domain interface; other site 813007755 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 813007756 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 813007757 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 813007758 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 813007759 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 813007760 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 813007761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 813007762 active site 813007763 motif I; other site 813007764 motif II; other site 813007765 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 813007766 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 813007767 NAD binding site [chemical binding]; other site 813007768 homotetramer interface [polypeptide binding]; other site 813007769 homodimer interface [polypeptide binding]; other site 813007770 substrate binding site [chemical binding]; other site 813007771 active site 813007772 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 813007773 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813007774 RNA binding surface [nucleotide binding]; other site 813007775 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 813007776 active site 813007777 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 813007778 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 813007779 minor groove reading motif; other site 813007780 helix-hairpin-helix signature motif; other site 813007781 substrate binding pocket [chemical binding]; other site 813007782 active site 813007783 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 813007784 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 813007785 DNA binding and oxoG recognition site [nucleotide binding] 813007786 Uncharacterized conserved protein [Function unknown]; Region: COG0327 813007787 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 813007788 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 813007789 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 813007790 ring oligomerisation interface [polypeptide binding]; other site 813007791 ATP/Mg binding site [chemical binding]; other site 813007792 stacking interactions; other site 813007793 hinge regions; other site 813007794 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 813007795 oligomerisation interface [polypeptide binding]; other site 813007796 mobile loop; other site 813007797 roof hairpin; other site 813007798 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 813007799 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 813007800 active site 813007801 Zn binding site [ion binding]; other site 813007802 Uncharacterized conserved protein [Function unknown]; Region: COG2912 813007803 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 813007804 IncA protein; Region: IncA; pfam04156 813007805 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 813007806 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 813007807 substrate binding site [chemical binding]; other site 813007808 hexamer interface [polypeptide binding]; other site 813007809 metal binding site [ion binding]; metal-binding site 813007810 elongation factor P; Provisional; Region: PRK12426 813007811 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813007812 RNA binding site [nucleotide binding]; other site 813007813 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 813007814 RNA binding site [nucleotide binding]; other site 813007815 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 813007816 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 813007817 carboxyltransferase (CT) interaction site; other site 813007818 biotinylation site [posttranslational modification]; other site 813007819 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 813007820 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 813007821 ATP-grasp domain; Region: ATP-grasp_4; cl17255 813007822 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 813007823 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 813007824 23S rRNA interface [nucleotide binding]; other site 813007825 L3 interface [polypeptide binding]; other site 813007826 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 813007827 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 813007828 NlpC/P60 family; Region: NLPC_P60; cl17555 813007829 adenylate kinase; Reviewed; Region: adk; PRK00279 813007830 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 813007831 AMP-binding site [chemical binding]; other site 813007832 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 813007833 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 813007834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813007835 dimer interface [polypeptide binding]; other site 813007836 conserved gate region; other site 813007837 putative PBP binding loops; other site 813007838 ABC-ATPase subunit interface; other site 813007839 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 813007840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813007841 Walker A/P-loop; other site 813007842 ATP binding site [chemical binding]; other site 813007843 Q-loop/lid; other site 813007844 ABC transporter signature motif; other site 813007845 Walker B; other site 813007846 D-loop; other site 813007847 H-loop/switch region; other site 813007848 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 813007849 Methyltransferase domain; Region: Methyltransf_23; pfam13489 813007850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813007851 S-adenosylmethionine binding site [chemical binding]; other site 813007852 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 813007853 Serine hydrolase (FSH1); Region: FSH1; pfam03959 813007854 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 813007855 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 813007856 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 813007857 active site 813007858 conserved hypothetical integral membrane protein; Region: TIGR00697 813007859 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 813007860 SEC-C motif; Region: SEC-C; pfam02810 813007861 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 813007862 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813007863 active site 813007864 ATP binding site [chemical binding]; other site 813007865 substrate binding site [chemical binding]; other site 813007866 activation loop (A-loop); other site 813007867 Uncharacterized conserved protein [Function unknown]; Region: COG1262 813007868 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 813007869 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 813007870 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 813007871 nucleotide binding pocket [chemical binding]; other site 813007872 K-X-D-G motif; other site 813007873 catalytic site [active] 813007874 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 813007875 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 813007876 Helix-hairpin-helix motif; Region: HHH; pfam00633 813007877 helix-hairpin-helix signature motif; other site 813007878 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 813007879 Dimer interface [polypeptide binding]; other site 813007880 BRCT sequence motif; other site 813007881 hypothetical protein; Provisional; Region: PRK06184 813007882 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 813007883 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 813007884 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 813007885 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 813007886 FtsX-like permease family; Region: FtsX; pfam02687 813007887 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 813007888 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 813007889 Walker A/P-loop; other site 813007890 ATP binding site [chemical binding]; other site 813007891 Q-loop/lid; other site 813007892 ABC transporter signature motif; other site 813007893 Walker B; other site 813007894 D-loop; other site 813007895 H-loop/switch region; other site 813007896 membrane-attack complex / perforin; Region: MACPF; smart00457 813007897 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 813007898 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813007899 PLD-like domain; Region: PLDc_2; pfam13091 813007900 putative active site [active] 813007901 catalytic site [active] 813007902 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813007903 PLD-like domain; Region: PLDc_2; pfam13091 813007904 putative active site [active] 813007905 catalytic site [active] 813007906 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 813007907 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 813007908 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 813007909 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 813007910 trp operon repressor, proteobacterial; Region: TrpR; TIGR01321 813007911 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 813007912 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 813007913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813007914 catalytic residue [active] 813007915 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 813007916 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 813007917 substrate binding site [chemical binding]; other site 813007918 active site 813007919 catalytic residues [active] 813007920 heterodimer interface [polypeptide binding]; other site 813007921 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 813007922 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 813007923 peptide binding site [polypeptide binding]; other site 813007924 putative disulfide oxidoreductase; Provisional; Region: PRK00611 813007925 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 813007926 putative active site [active] 813007927 redox center [active] 813007928 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 813007929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813007930 Walker A/P-loop; other site 813007931 ATP binding site [chemical binding]; other site 813007932 Q-loop/lid; other site 813007933 ABC transporter signature motif; other site 813007934 Walker B; other site 813007935 D-loop; other site 813007936 H-loop/switch region; other site 813007937 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 813007938 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 813007939 Ligand binding site; other site 813007940 oligomer interface; other site 813007941 CTP synthetase; Validated; Region: pyrG; PRK05380 813007942 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 813007943 Catalytic site [active] 813007944 active site 813007945 UTP binding site [chemical binding]; other site 813007946 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 813007947 active site 813007948 putative oxyanion hole; other site 813007949 catalytic triad [active] 813007950 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 813007951 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 813007952 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 813007953 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 813007954 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 813007955 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 813007956 putative active site [active] 813007957 DNA polymerase III subunit delta'; Validated; Region: PRK05917 813007958 DNA polymerase III subunit delta'; Validated; Region: PRK08485 813007959 thymidylate kinase; Validated; Region: tmk; PRK00698 813007960 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 813007961 TMP-binding site; other site 813007962 ATP-binding site [chemical binding]; other site 813007963 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 813007964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813007965 ATP binding site [chemical binding]; other site 813007966 Mg2+ binding site [ion binding]; other site 813007967 G-X-G motif; other site 813007968 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 813007969 anchoring element; other site 813007970 dimer interface [polypeptide binding]; other site 813007971 ATP binding site [chemical binding]; other site 813007972 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 813007973 active site 813007974 putative metal-binding site [ion binding]; other site 813007975 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 813007976 Protein of unknown function (DUF721); Region: DUF721; pfam05258 813007977 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 813007978 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 813007979 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 813007980 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 813007981 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 813007982 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 813007983 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 813007984 peptide binding site [polypeptide binding]; other site 813007985 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 813007986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813007987 dimer interface [polypeptide binding]; other site 813007988 conserved gate region; other site 813007989 putative PBP binding loops; other site 813007990 ABC-ATPase subunit interface; other site 813007991 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 813007992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813007993 dimer interface [polypeptide binding]; other site 813007994 conserved gate region; other site 813007995 putative PBP binding loops; other site 813007996 ABC-ATPase subunit interface; other site 813007997 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813007998 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 813007999 Walker A/P-loop; other site 813008000 ATP binding site [chemical binding]; other site 813008001 Q-loop/lid; other site 813008002 ABC transporter signature motif; other site 813008003 Walker B; other site 813008004 D-loop; other site 813008005 H-loop/switch region; other site 813008006 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 813008007 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 813008008 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813008009 Walker A/P-loop; other site 813008010 ATP binding site [chemical binding]; other site 813008011 Q-loop/lid; other site 813008012 ABC transporter signature motif; other site 813008013 Walker B; other site 813008014 D-loop; other site 813008015 H-loop/switch region; other site 813008016 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813008017 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 813008018 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 813008019 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 813008020 transmembrane helices; other site 813008021 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 813008022 active site 813008023 ADP/pyrophosphate binding site [chemical binding]; other site 813008024 dimerization interface [polypeptide binding]; other site 813008025 allosteric effector site; other site 813008026 fructose-1,6-bisphosphate binding site; other site 813008027 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 813008028 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 813008029 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 813008030 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 813008031 active site 813008032 ADP/pyrophosphate binding site [chemical binding]; other site 813008033 dimerization interface [polypeptide binding]; other site 813008034 allosteric effector site; other site 813008035 fructose-1,6-bisphosphate binding site; other site 813008036 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 813008037 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 813008038 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 813008039 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 813008040 HIGH motif; other site 813008041 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 813008042 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 813008043 active site 813008044 KMSKS motif; other site 813008045 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 813008046 tRNA binding surface [nucleotide binding]; other site 813008047 Putative transcriptional regulator [Transcription]; Region: COG1678 813008048 Uncharacterized conserved protein [Function unknown]; Region: COG1259 813008049 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 813008050 tetramer (dimer of dimers) interface [polypeptide binding]; other site 813008051 active site 813008052 dimer interface [polypeptide binding]; other site 813008053 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 813008054 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 813008055 putative active site; other site 813008056 catalytic residue [active] 813008057 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 813008058 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 813008059 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 813008060 Ligand Binding Site [chemical binding]; other site 813008061 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 813008062 prenyltransferase; Reviewed; Region: ubiA; PRK12876 813008063 UbiA prenyltransferase family; Region: UbiA; pfam01040 813008064 aromatic acid decarboxylase; Validated; Region: PRK05920 813008065 Flavoprotein; Region: Flavoprotein; pfam02441 813008066 Uncharacterized conserved protein [Function unknown]; Region: COG1284 813008067 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 813008068 IncA protein; Region: IncA; pfam04156 813008069 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 813008070 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 813008071 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 813008072 Na2 binding site [ion binding]; other site 813008073 putative substrate binding site 1 [chemical binding]; other site 813008074 Na binding site 1 [ion binding]; other site 813008075 putative substrate binding site 2 [chemical binding]; other site 813008076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813008077 putative substrate translocation pore; other site 813008078 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 813008079 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 813008080 ligand binding site [chemical binding]; other site 813008081 flexible hinge region; other site 813008082 acyl carrier protein; Provisional; Region: acpP; PRK00982 813008083 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 813008084 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 813008085 NAD(P) binding site [chemical binding]; other site 813008086 homotetramer interface [polypeptide binding]; other site 813008087 homodimer interface [polypeptide binding]; other site 813008088 active site 813008089 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 813008090 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 813008091 dimer interface [polypeptide binding]; other site 813008092 active site 813008093 CoA binding pocket [chemical binding]; other site 813008094 recombination protein RecR; Region: recR; TIGR00615 813008095 RecR protein; Region: RecR; pfam02132 813008096 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 813008097 putative active site [active] 813008098 putative metal-binding site [ion binding]; other site 813008099 tetramer interface [polypeptide binding]; other site 813008100 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 813008101 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813008102 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813008103 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813008104 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813008105 Surface antigen; Region: Bac_surface_Ag; pfam01103 813008106 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 813008107 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 813008108 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 813008109 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 813008110 trimer interface [polypeptide binding]; other site 813008111 active site 813008112 UDP-GlcNAc binding site [chemical binding]; other site 813008113 lipid binding site [chemical binding]; lipid-binding site 813008114 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 813008115 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 813008116 tetramer interface [polypeptide binding]; other site 813008117 TPP-binding site [chemical binding]; other site 813008118 heterodimer interface [polypeptide binding]; other site 813008119 phosphorylation loop region [posttranslational modification] 813008120 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 813008121 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 813008122 alpha subunit interface [polypeptide binding]; other site 813008123 TPP binding site [chemical binding]; other site 813008124 heterodimer interface [polypeptide binding]; other site 813008125 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813008126 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 813008127 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813008128 E3 interaction surface; other site 813008129 lipoyl attachment site [posttranslational modification]; other site 813008130 e3 binding domain; Region: E3_binding; pfam02817 813008131 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813008132 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 813008133 homodimer interface [polypeptide binding]; other site 813008134 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 813008135 active site pocket [active] 813008136 chromosomal replication initiation protein; Provisional; Region: PRK12422 813008137 DnaA N-terminal domain; Region: DnaA_N; pfam11638 813008138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813008139 Walker A motif; other site 813008140 ATP binding site [chemical binding]; other site 813008141 Walker B motif; other site 813008142 arginine finger; other site 813008143 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 813008144 DnaA box-binding interface [nucleotide binding]; other site 813008145 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 813008146 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 813008147 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 813008148 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 813008149 homodimer interface [polypeptide binding]; other site 813008150 metal binding site [ion binding]; metal-binding site 813008151 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 813008152 Domain of unknown function DUF21; Region: DUF21; pfam01595 813008153 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813008154 Transporter associated domain; Region: CorC_HlyC; smart01091 813008155 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 813008156 Domain of unknown function DUF21; Region: DUF21; pfam01595 813008157 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813008158 Transporter associated domain; Region: CorC_HlyC; smart01091 813008159 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 813008160 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 813008161 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813008162 catalytic residue [active] 813008163 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 813008164 Protein phosphatase 2C; Region: PP2C; pfam00481 813008165 active site 813008166 Uncharacterized conserved protein [Function unknown]; Region: COG5465 813008167 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 813008168 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 813008169 active site 813008170 catalytic site [active] 813008171 substrate binding site [chemical binding]; other site 813008172 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 813008173 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 813008174 nucleosidase; Provisional; Region: PRK05634 813008175 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 813008176 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 813008177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813008178 Walker A/P-loop; other site 813008179 ATP binding site [chemical binding]; other site 813008180 Q-loop/lid; other site 813008181 ABC transporter signature motif; other site 813008182 Walker B; other site 813008183 D-loop; other site 813008184 H-loop/switch region; other site 813008185 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 813008186 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 813008187 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 813008188 IHF - DNA interface [nucleotide binding]; other site 813008189 IHF dimer interface [polypeptide binding]; other site 813008190 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 813008191 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 813008192 active site 813008193 metal binding site [ion binding]; metal-binding site 813008194 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 813008195 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 813008196 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813008197 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813008198 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 813008199 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 813008200 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 813008201 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 813008202 MraW methylase family; Region: Methyltransf_5; pfam01795 813008203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813008204 TPR motif; other site 813008205 binding surface 813008206 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 813008207 DnaA N-terminal domain; Region: DnaA_N; pfam11638 813008208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813008209 Walker A motif; other site 813008210 ATP binding site [chemical binding]; other site 813008211 Walker B motif; other site 813008212 arginine finger; other site 813008213 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 813008214 DnaA box-binding interface [nucleotide binding]; other site 813008215 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 813008216 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 813008217 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 813008218 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 813008219 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 813008220 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 813008221 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 813008222 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 813008223 lipoyl attachment site [posttranslational modification]; other site 813008224 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 813008225 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 813008226 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813008227 putative active site [active] 813008228 catalytic site [active] 813008229 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813008230 putative active site [active] 813008231 catalytic site [active] 813008232 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 813008233 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 813008234 Clp amino terminal domain; Region: Clp_N; pfam02861 813008235 Clp amino terminal domain; Region: Clp_N; pfam02861 813008236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813008237 Walker A motif; other site 813008238 ATP binding site [chemical binding]; other site 813008239 Walker B motif; other site 813008240 arginine finger; other site 813008241 UvrB/uvrC motif; Region: UVR; pfam02151 813008242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813008243 Walker A motif; other site 813008244 ATP binding site [chemical binding]; other site 813008245 Walker B motif; other site 813008246 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 813008247 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 813008248 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 813008249 Ligand Binding Site [chemical binding]; other site 813008250 Helix-turn-helix domain; Region: HTH_17; pfam12728 813008251 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 813008252 active site 813008253 phosphorylation site [posttranslational modification] 813008254 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 813008255 active site 813008256 phosphorylation site [posttranslational modification] 813008257 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 813008258 trimer interface [polypeptide binding]; other site 813008259 active site 813008260 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 813008261 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 813008262 ribonuclease III; Reviewed; Region: rnc; PRK00102 813008263 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 813008264 dimerization interface [polypeptide binding]; other site 813008265 active site 813008266 metal binding site [ion binding]; metal-binding site 813008267 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 813008268 dsRNA binding site [nucleotide binding]; other site 813008269 DNA repair protein RadA; Provisional; Region: PRK11823 813008270 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 813008271 Walker A motif/ATP binding site; other site 813008272 ATP binding site [chemical binding]; other site 813008273 Walker B motif; other site 813008274 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 813008275 porphobilinogen deaminase; Provisional; Region: PRK01066 813008276 Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379 813008277 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 813008278 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813008279 active site 813008280 ATP binding site [chemical binding]; other site 813008281 substrate binding site [chemical binding]; other site 813008282 activation loop (A-loop); other site 813008283 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 813008284 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 813008285 HIGH motif; other site 813008286 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 813008287 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 813008288 active site 813008289 KMSKS motif; other site 813008290 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 813008291 tRNA binding surface [nucleotide binding]; other site 813008292 anticodon binding site; other site 813008293 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 813008294 V-type ATP synthase subunit K; Provisional; Region: PRK09621 813008295 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 813008296 V-type ATP synthase subunit I; Validated; Region: PRK05771 813008297 Protein of unknown function (DUF1319); Region: DUF1319; pfam07028 813008298 V-type ATP synthase subunit D; Provisional; Region: PRK02195 813008299 V-type ATP synthase subunit B; Provisional; Region: PRK02118 813008300 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813008301 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 813008302 Walker A motif homologous position; other site 813008303 Walker B motif; other site 813008304 V-type ATP synthase subunit A; Provisional; Region: PRK04192 813008305 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813008306 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 813008307 Walker A motif/ATP binding site; other site 813008308 Walker B motif; other site 813008309 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 813008310 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 813008311 V-type ATP synthase subunit E; Provisional; Region: PRK01005 813008312 V-type ATP synthase subunit E; Provisional; Region: PRK01558 813008313 transaldolase-like protein; Provisional; Region: PTZ00411 813008314 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 813008315 active site 813008316 dimer interface [polypeptide binding]; other site 813008317 catalytic residue [active] 813008318 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 813008319 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 813008320 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 813008321 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 813008322 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 813008323 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 813008324 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 813008325 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 813008326 DNA binding site [nucleotide binding] 813008327 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 813008328 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 813008329 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 813008330 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 813008331 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 813008332 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 813008333 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 813008334 RPB12 interaction site [polypeptide binding]; other site 813008335 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 813008336 RPB3 interaction site [polypeptide binding]; other site 813008337 RPB1 interaction site [polypeptide binding]; other site 813008338 RPB11 interaction site [polypeptide binding]; other site 813008339 RPB10 interaction site [polypeptide binding]; other site 813008340 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 813008341 L11 interface [polypeptide binding]; other site 813008342 putative EF-Tu interaction site [polypeptide binding]; other site 813008343 putative EF-G interaction site [polypeptide binding]; other site 813008344 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 813008345 23S rRNA interface [nucleotide binding]; other site 813008346 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 813008347 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 813008348 mRNA/rRNA interface [nucleotide binding]; other site 813008349 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 813008350 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 813008351 putative thiostrepton binding site; other site 813008352 23S rRNA interface [nucleotide binding]; other site 813008353 L7/L12 interface [polypeptide binding]; other site 813008354 L25 interface [polypeptide binding]; other site 813008355 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 813008356 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 813008357 putative homodimer interface [polypeptide binding]; other site 813008358 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 813008359 heterodimer interface [polypeptide binding]; other site 813008360 homodimer interface [polypeptide binding]; other site 813008361 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 813008362 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 813008363 rRNA binding site [nucleotide binding]; other site 813008364 predicted 30S ribosome binding site; other site 813008365 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 813008366 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 813008367 active site 813008368 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 813008369 triosephosphate isomerase; Provisional; Region: PRK14565 813008370 substrate binding site [chemical binding]; other site 813008371 dimer interface [polypeptide binding]; other site 813008372 catalytic triad [active] 813008373 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 813008374 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 813008375 generic binding surface II; other site 813008376 generic binding surface I; other site 813008377 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 813008378 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 813008379 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 813008380 TPP-binding site [chemical binding]; other site 813008381 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 813008382 PYR/PP interface [polypeptide binding]; other site 813008383 dimer interface [polypeptide binding]; other site 813008384 TPP binding site [chemical binding]; other site 813008385 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813008386 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 813008387 pyruvate kinase; Region: pyruv_kin; TIGR01064 813008388 domain interfaces; other site 813008389 active site 813008390 excinuclease ABC subunit A; Provisional; Region: PRK00635 813008391 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 813008392 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 813008393 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 813008394 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813008395 Walker A/P-loop; other site 813008396 ATP binding site [chemical binding]; other site 813008397 Q-loop/lid; other site 813008398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813008399 ABC transporter signature motif; other site 813008400 Walker B; other site 813008401 D-loop; other site 813008402 H-loop/switch region; other site 813008403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813008404 Walker A/P-loop; other site 813008405 ATP binding site [chemical binding]; other site 813008406 Q-loop/lid; other site 813008407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813008408 Q-loop/lid; other site 813008409 ABC transporter signature motif; other site 813008410 Walker B; other site 813008411 D-loop; other site 813008412 H-loop/switch region; other site 813008413 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 813008414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813008415 Walker A motif; other site 813008416 ATP binding site [chemical binding]; other site 813008417 Walker B motif; other site 813008418 arginine finger; other site 813008419 hypothetical protein; Validated; Region: PRK00153 813008420 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 813008421 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 813008422 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 813008423 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 813008424 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 813008425 dimerization domain swap beta strand [polypeptide binding]; other site 813008426 regulatory protein interface [polypeptide binding]; other site 813008427 active site 813008428 regulatory phosphorylation site [posttranslational modification]; other site 813008429 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 813008430 Competence protein; Region: Competence; pfam03772 813008431 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 813008432 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 813008433 tetramer interface [polypeptide binding]; other site 813008434 TPP-binding site [chemical binding]; other site 813008435 heterodimer interface [polypeptide binding]; other site 813008436 phosphorylation loop region [posttranslational modification] 813008437 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 813008438 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 813008439 alpha subunit interface [polypeptide binding]; other site 813008440 TPP binding site [chemical binding]; other site 813008441 heterodimer interface [polypeptide binding]; other site 813008442 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813008443 chaperone protein DnaJ; Provisional; Region: PRK14284 813008444 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 813008445 HSP70 interaction site [polypeptide binding]; other site 813008446 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 813008447 Zn binding sites [ion binding]; other site 813008448 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 813008449 dimer interface [polypeptide binding]; other site 813008450 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 813008451 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 813008452 Glycoprotease family; Region: Peptidase_M22; pfam00814 813008453 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 813008454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813008455 Walker A motif; other site 813008456 ATP binding site [chemical binding]; other site 813008457 Walker B motif; other site 813008458 arginine finger; other site 813008459 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 813008460 ribonuclease Z; Region: RNase_Z; TIGR02651 813008461 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 813008462 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 813008463 active site 813008464 Int/Topo IB signature motif; other site 813008465 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 813008466 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813008467 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813008468 ABC transporter; Region: ABC_tran_2; pfam12848 813008469 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813008470 Maf-like protein; Region: Maf; pfam02545 813008471 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 813008472 active site 813008473 dimer interface [polypeptide binding]; other site 813008474 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 813008475 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 813008476 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 813008477 active site 813008478 catalytic residues [active] 813008479 metal binding site [ion binding]; metal-binding site 813008480 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 813008481 dimethyladenosine transferase; Region: ksgA; TIGR00755 813008482 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 813008483 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 813008484 catalytic residues [active] 813008485 dihydrodipicolinate synthase; Region: dapA; TIGR00674 813008486 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 813008487 inhibitor site; inhibition site 813008488 active site 813008489 dimer interface [polypeptide binding]; other site 813008490 catalytic residue [active] 813008491 aspartate kinase; Provisional; Region: PRK05925 813008492 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 813008493 putative catalytic residues [active] 813008494 nucleotide binding site [chemical binding]; other site 813008495 aspartate binding site [chemical binding]; other site 813008496 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 813008497 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 813008498 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 813008499 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 813008500 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 813008501 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 813008502 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 813008503 hinge; other site 813008504 active site 813008505 shikimate kinase; Provisional; Region: PRK00625 813008506 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 813008507 ADP binding site [chemical binding]; other site 813008508 magnesium binding site [ion binding]; other site 813008509 putative shikimate binding site; other site 813008510 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 813008511 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 813008512 Tetramer interface [polypeptide binding]; other site 813008513 active site 813008514 FMN-binding site [chemical binding]; other site 813008515 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 813008516 active site 813008517 dimer interface [polypeptide binding]; other site 813008518 metal binding site [ion binding]; metal-binding site 813008519 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 813008520 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 813008521 active site 813008522 catalytic residue [active] 813008523 dimer interface [polypeptide binding]; other site 813008524 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 813008525 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 813008526 shikimate binding site; other site 813008527 NAD(P) binding site [chemical binding]; other site 813008528 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 813008529 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 813008530 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 813008531 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 813008532 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 813008533 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 813008534 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 813008535 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 813008536 active site 813008537 dimer interface [polypeptide binding]; other site 813008538 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 813008539 dimer interface [polypeptide binding]; other site 813008540 active site 813008541 GTPases [General function prediction only]; Region: HflX; COG2262 813008542 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 813008543 HflX GTPase family; Region: HflX; cd01878 813008544 G1 box; other site 813008545 GTP/Mg2+ binding site [chemical binding]; other site 813008546 Switch I region; other site 813008547 G2 box; other site 813008548 G3 box; other site 813008549 Switch II region; other site 813008550 G4 box; other site 813008551 G5 box; other site 813008552 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 813008553 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 813008554 substrate binding pocket [chemical binding]; other site 813008555 membrane-bound complex binding site; other site 813008556 hinge residues; other site 813008557 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 813008558 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 813008559 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 813008560 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 813008561 nucleotide binding site/active site [active] 813008562 Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286 813008563 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 813008564 hypothetical protein; Validated; Region: PRK00647 813008565 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 813008566 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 813008567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 813008568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813008569 homodimer interface [polypeptide binding]; other site 813008570 catalytic residue [active] 813008571 ABC transporter substrate binding protein; Region: ABC_sub_bind; pfam04392 813008572 prolyl-tRNA synthetase; Provisional; Region: PRK09194 813008573 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 813008574 dimer interface [polypeptide binding]; other site 813008575 motif 1; other site 813008576 active site 813008577 motif 2; other site 813008578 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 813008579 putative deacylase active site [active] 813008580 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813008581 active site 813008582 motif 3; other site 813008583 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 813008584 anticodon binding site; other site 813008585 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 813008586 GrpE; Region: GrpE; pfam01025 813008587 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 813008588 dimer interface [polypeptide binding]; other site 813008589 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 813008590 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 813008591 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 813008592 nucleotide binding site [chemical binding]; other site 813008593 NEF interaction site [polypeptide binding]; other site 813008594 SBD interface [polypeptide binding]; other site 813008595 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 813008596 Exoribonuclease R [Transcription]; Region: VacB; COG0557 813008597 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 813008598 RNB domain; Region: RNB; pfam00773 813008599 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 813008600 Putative zinc ribbon domain; Region: DUF164; pfam02591 813008601 KpsF/GutQ family protein; Region: kpsF; TIGR00393 813008602 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 813008603 putative active site [active] 813008604 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 813008605 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 813008606 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813008607 E3 interaction surface; other site 813008608 lipoyl attachment site [posttranslational modification]; other site 813008609 e3 binding domain; Region: E3_binding; pfam02817 813008610 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813008611 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 813008612 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 813008613 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 813008614 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 813008615 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 813008616 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 813008617 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 813008618 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 813008619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813008620 S-adenosylmethionine binding site [chemical binding]; other site 813008621 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 813008622 Lumazine binding domain; Region: Lum_binding; pfam00677 813008623 Lumazine binding domain; Region: Lum_binding; pfam00677 813008624 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 813008625 ATP cone domain; Region: ATP-cone; pfam03477 813008626 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 813008627 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 813008628 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 813008629 amino acid carrier protein; Region: agcS; TIGR00835 813008630 poly(A) polymerase; Region: pcnB; TIGR01942 813008631 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 813008632 active site 813008633 NTP binding site [chemical binding]; other site 813008634 metal binding triad [ion binding]; metal-binding site 813008635 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 813008636 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 813008637 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 813008638 Predicted membrane protein [Function unknown]; Region: COG3952 813008639 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 813008640 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813008641 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813008642 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813008643 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813008644 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813008645 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 813008646 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 813008647 intersubunit interface [polypeptide binding]; other site 813008648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813008649 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 813008650 Walker A/P-loop; other site 813008651 ATP binding site [chemical binding]; other site 813008652 Q-loop/lid; other site 813008653 ABC transporter signature motif; other site 813008654 Walker B; other site 813008655 D-loop; other site 813008656 H-loop/switch region; other site 813008657 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813008658 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813008659 ABC-ATPase subunit interface; other site 813008660 dimer interface [polypeptide binding]; other site 813008661 putative PBP binding regions; other site 813008662 GTPase CgtA; Reviewed; Region: obgE; PRK12299 813008663 GTP1/OBG; Region: GTP1_OBG; pfam01018 813008664 Obg GTPase; Region: Obg; cd01898 813008665 G1 box; other site 813008666 GTP/Mg2+ binding site [chemical binding]; other site 813008667 Switch I region; other site 813008668 G2 box; other site 813008669 G3 box; other site 813008670 Switch II region; other site 813008671 G4 box; other site 813008672 G5 box; other site 813008673 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 813008674 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 813008675 Uncharacterized conserved protein [Function unknown]; Region: COG2928 813008676 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 813008677 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 813008678 FOG: CBS domain [General function prediction only]; Region: COG0517 813008679 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813008680 Transporter associated domain; Region: CorC_HlyC; smart01091 813008681 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 813008682 anti sigma factor interaction site; other site 813008683 regulatory phosphorylation site [posttranslational modification]; other site 813008684 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 813008685 hypothetical protein; Provisional; Region: PRK05926 813008686 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813008687 FeS/SAM binding site; other site 813008688 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 813008689 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 813008690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813008691 S-adenosylmethionine binding site [chemical binding]; other site 813008692 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 813008693 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 813008694 diaminopimelate epimerase; Region: DapF; TIGR00652 813008695 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 813008696 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 813008697 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 813008698 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 813008699 oligomer interface [polypeptide binding]; other site 813008700 active site residues [active] 813008701 serine hydroxymethyltransferase; Provisional; Region: PRK13580 813008702 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 813008703 dimer interface [polypeptide binding]; other site 813008704 active site 813008705 glycine-pyridoxal phosphate binding site [chemical binding]; other site 813008706 folate binding site [chemical binding]; other site 813008707 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 813008708 active site 813008709 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 813008710 homotrimer interaction site [polypeptide binding]; other site 813008711 zinc binding site [ion binding]; other site 813008712 CDP-binding sites; other site 813008713 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 813008714 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 813008715 FAD binding pocket [chemical binding]; other site 813008716 conserved FAD binding motif [chemical binding]; other site 813008717 phosphate binding motif [ion binding]; other site 813008718 beta-alpha-beta structure motif; other site 813008719 NAD binding pocket [chemical binding]; other site 813008720 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 813008721 elongation factor G; Reviewed; Region: PRK12739 813008722 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 813008723 G1 box; other site 813008724 putative GEF interaction site [polypeptide binding]; other site 813008725 GTP/Mg2+ binding site [chemical binding]; other site 813008726 Switch I region; other site 813008727 G2 box; other site 813008728 G3 box; other site 813008729 Switch II region; other site 813008730 G4 box; other site 813008731 G5 box; other site 813008732 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 813008733 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 813008734 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 813008735 30S ribosomal protein S7; Validated; Region: PRK05302 813008736 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 813008737 S17 interaction site [polypeptide binding]; other site 813008738 S8 interaction site; other site 813008739 16S rRNA interaction site [nucleotide binding]; other site 813008740 streptomycin interaction site [chemical binding]; other site 813008741 23S rRNA interaction site [nucleotide binding]; other site 813008742 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 813008743 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 813008744 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 813008745 Domain of unknown function DUF11; Region: DUF11; pfam01345 813008746 Domain of unknown function DUF11; Region: DUF11; pfam01345 813008747 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 813008748 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 813008749 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 813008750 HIGH motif; other site 813008751 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 813008752 active site 813008753 KMSKS motif; other site 813008754 Helix-turn-helix domain; Region: HTH_17; pfam12728 813008755 Helix-turn-helix domain; Region: HTH_17; cl17695 813008756 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 813008757 DHH family; Region: DHH; pfam01368 813008758 DHHA1 domain; Region: DHHA1; pfam02272 813008759 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 813008760 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 813008761 Protein export membrane protein; Region: SecD_SecF; pfam02355 813008762 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 813008763 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 813008764 catalytic residue [active] 813008765 putative FPP diphosphate binding site; other site 813008766 putative FPP binding hydrophobic cleft; other site 813008767 dimer interface [polypeptide binding]; other site 813008768 putative IPP diphosphate binding site; other site 813008769 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 813008770 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 813008771 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 813008772 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 813008773 CMP-binding site; other site 813008774 The sites determining sugar specificity; other site 813008775 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 813008776 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 813008777 putative acyl-acceptor binding pocket; other site 813008778 arginine-tRNA ligase; Region: PLN02286 813008779 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 813008780 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 813008781 active site 813008782 HIGH motif; other site 813008783 KMSK motif region; other site 813008784 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813008785 tRNA binding surface [nucleotide binding]; other site 813008786 anticodon binding site; other site 813008787 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 813008788 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 813008789 hinge; other site 813008790 active site 813008791 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 813008792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 813008793 Coenzyme A binding pocket [chemical binding]; other site 813008794 PCRF domain; Region: PCRF; pfam03462 813008795 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 813008796 RF-1 domain; Region: RF-1; pfam00472 813008797 SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531 813008798 SWI complex, BAF60b domains; Region: SWIB; smart00151 813008799 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 813008800 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813008801 putative active site [active] 813008802 putative metal binding site [ion binding]; other site 813008803 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 813008804 substrate binding site; other site 813008805 dimer interface; other site 813008806 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 813008807 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 813008808 dimerization interface 3.5A [polypeptide binding]; other site 813008809 active site 813008810 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 813008811 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 813008812 active site 813008813 motif I; other site 813008814 motif II; other site 813008815 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 813008816 PAS domain; Region: PAS; smart00091 813008817 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 813008818 dimer interface [polypeptide binding]; other site 813008819 phosphorylation site [posttranslational modification] 813008820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813008821 ATP binding site [chemical binding]; other site 813008822 Mg2+ binding site [ion binding]; other site 813008823 G-X-G motif; other site 813008824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 813008825 Response regulator receiver domain; Region: Response_reg; pfam00072 813008826 active site 813008827 phosphorylation site [posttranslational modification] 813008828 intermolecular recognition site; other site 813008829 dimerization interface [polypeptide binding]; other site 813008830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813008831 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 813008832 Walker A motif; other site 813008833 ATP binding site [chemical binding]; other site 813008834 Walker B motif; other site 813008835 arginine finger; other site 813008836 Uncharacterized conserved protein [Function unknown]; Region: COG1723 813008837 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 813008838 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 813008839 putative tRNA-binding site [nucleotide binding]; other site 813008840 B3/4 domain; Region: B3_4; pfam03483 813008841 tRNA synthetase B5 domain; Region: B5; pfam03484 813008842 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 813008843 dimer interface [polypeptide binding]; other site 813008844 motif 1; other site 813008845 motif 3; other site 813008846 motif 2; other site 813008847 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 813008848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813008849 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 813008850 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 813008851 DNA binding site [nucleotide binding] 813008852 active site 813008853 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 813008854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813008855 dimer interface [polypeptide binding]; other site 813008856 conserved gate region; other site 813008857 putative PBP binding loops; other site 813008858 ABC-ATPase subunit interface; other site 813008859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 813008860 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 813008861 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 813008862 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 813008863 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 813008864 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 813008865 putative active site [active] 813008866 putative metal binding site [ion binding]; other site 813008867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813008868 binding surface 813008869 TPR motif; other site 813008870 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 813008871 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 813008872 C-terminal domain interface [polypeptide binding]; other site 813008873 active site 813008874 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 813008875 active site 813008876 N-terminal domain interface [polypeptide binding]; other site 813008877 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 813008878 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 813008879 substrate binding pocket [chemical binding]; other site 813008880 membrane-bound complex binding site; other site 813008881 hinge residues; other site 813008882 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 813008883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813008884 S-adenosylmethionine binding site [chemical binding]; other site 813008885 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 813008886 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813008887 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 813008888 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 813008889 ligand binding site; other site 813008890 oligomer interface; other site 813008891 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 813008892 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 813008893 N-terminal domain interface [polypeptide binding]; other site 813008894 sulfate 1 binding site; other site 813008895 transcription termination factor Rho; Region: rho; TIGR00767 813008896 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 813008897 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 813008898 RNA binding site [nucleotide binding]; other site 813008899 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 813008900 multimer interface [polypeptide binding]; other site 813008901 Walker A motif; other site 813008902 ATP binding site [chemical binding]; other site 813008903 Walker B motif; other site 813008904 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 813008905 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 813008906 CoA-binding site [chemical binding]; other site 813008907 ATP-binding [chemical binding]; other site 813008908 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 813008909 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 813008910 tandem repeat interface [polypeptide binding]; other site 813008911 oligomer interface [polypeptide binding]; other site 813008912 active site residues [active] 813008913 TLC ATP/ADP transporter; Region: TLC; pfam03219 813008914 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 813008915 replicative DNA helicase; Provisional; Region: PRK06321 813008916 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 813008917 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 813008918 Walker A motif; other site 813008919 ATP binding site [chemical binding]; other site 813008920 Walker B motif; other site 813008921 DNA binding loops [nucleotide binding] 813008922 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 813008923 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 813008924 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 813008925 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 813008926 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 813008927 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 813008928 RuvA N terminal domain; Region: RuvA_N; pfam01330 813008929 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 813008930 active site 813008931 putative DNA-binding cleft [nucleotide binding]; other site 813008932 dimer interface [polypeptide binding]; other site 813008933 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 813008934 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 813008935 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 813008936 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 813008937 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 813008938 alphaNTD - beta interaction site [polypeptide binding]; other site 813008939 alphaNTD homodimer interface [polypeptide binding]; other site 813008940 alphaNTD - beta' interaction site [polypeptide binding]; other site 813008941 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 813008942 30S ribosomal protein S11; Validated; Region: PRK05309 813008943 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 813008944 30S ribosomal protein S13; Region: bact_S13; TIGR03631 813008945 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 813008946 SecY translocase; Region: SecY; pfam00344 813008947 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 813008948 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 813008949 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 813008950 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 813008951 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 813008952 5S rRNA interface [nucleotide binding]; other site 813008953 23S rRNA interface [nucleotide binding]; other site 813008954 L5 interface [polypeptide binding]; other site 813008955 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 813008956 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 813008957 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 813008958 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 813008959 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 813008960 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 813008961 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 813008962 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 813008963 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 813008964 RNA binding site [nucleotide binding]; other site 813008965 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 813008966 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 813008967 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 813008968 23S rRNA interface [nucleotide binding]; other site 813008969 putative translocon interaction site; other site 813008970 signal recognition particle (SRP54) interaction site; other site 813008971 L23 interface [polypeptide binding]; other site 813008972 trigger factor interaction site; other site 813008973 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 813008974 23S rRNA interface [nucleotide binding]; other site 813008975 5S rRNA interface [nucleotide binding]; other site 813008976 putative antibiotic binding site [chemical binding]; other site 813008977 L25 interface [polypeptide binding]; other site 813008978 L27 interface [polypeptide binding]; other site 813008979 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 813008980 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 813008981 G-X-X-G motif; other site 813008982 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 813008983 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 813008984 putative translocon binding site; other site 813008985 protein-rRNA interface [nucleotide binding]; other site 813008986 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 813008987 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 813008988 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 813008989 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 813008990 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 813008991 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 813008992 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 813008993 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 813008994 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 813008995 putative active site [active] 813008996 substrate binding site [chemical binding]; other site 813008997 putative cosubstrate binding site; other site 813008998 catalytic site [active] 813008999 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 813009000 substrate binding site [chemical binding]; other site 813009001 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 813009002 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 813009003 active site 813009004 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 813009005 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 813009006 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 813009007 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 813009008 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 813009009 putative active site [active] 813009010 catalytic triad [active] 813009011 putative dimer interface [polypeptide binding]; other site 813009012 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 813009013 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 813009014 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 813009015 active site 813009016 catalytic site [active] 813009017 substrate binding site [chemical binding]; other site 813009018 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 813009019 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 813009020 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 813009021 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 813009022 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813009023 catalytic residues [active] 813009024 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 813009025 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 813009026 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 813009027 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 813009028 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 813009029 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 813009030 dimer interface [polypeptide binding]; other site 813009031 anticodon binding site; other site 813009032 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 813009033 homodimer interface [polypeptide binding]; other site 813009034 motif 1; other site 813009035 active site 813009036 motif 2; other site 813009037 GAD domain; Region: GAD; pfam02938 813009038 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813009039 active site 813009040 motif 3; other site 813009041 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 813009042 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 813009043 dimer interface [polypeptide binding]; other site 813009044 motif 1; other site 813009045 active site 813009046 motif 2; other site 813009047 motif 3; other site 813009048 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 813009049 anticodon binding site; other site 813009050 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 813009051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813009052 putative substrate translocation pore; other site 813009053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813009054 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 813009055 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 813009056 active site 813009057 PHP Thumb interface [polypeptide binding]; other site 813009058 metal binding site [ion binding]; metal-binding site 813009059 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 813009060 generic binding surface I; other site 813009061 generic binding surface II; other site 813009062 TPR repeat; Region: TPR_11; pfam13414 813009063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813009064 binding surface 813009065 TPR motif; other site 813009066 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 813009067 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 813009068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 813009069 Mg2+ binding site [ion binding]; other site 813009070 branched-chain amino acid uptake carrier; Region: livcs; TIGR00796 813009071 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 813009072 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813009073 ATP binding site [chemical binding]; other site 813009074 putative Mg++ binding site [ion binding]; other site 813009075 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813009076 ATP-binding site [chemical binding]; other site 813009077 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 813009078 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 813009079 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 813009080 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 813009081 lipoate synthase; Region: lipA; TIGR00510 813009082 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813009083 FeS/SAM binding site; other site 813009084 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 813009085 type III secretion system protein; Validated; Region: PRK06328 813009086 Flagellar assembly protein FliH; Region: FliH; pfam02108 813009087 type III secretion system protein; Reviewed; Region: PRK09617 813009088 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 813009089 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 813009090 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 813009091 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 813009092 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 813009093 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 813009094 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 813009095 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 813009096 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 813009097 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 813009098 Walker A motif; other site 813009099 ATP binding site [chemical binding]; other site 813009100 Walker B motif; other site 813009101 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 813009102 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813009103 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 813009104 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 813009105 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 813009106 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 813009107 active site 813009108 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 813009109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813009110 ATP binding site [chemical binding]; other site 813009111 Mg2+ binding site [ion binding]; other site 813009112 G-X-G motif; other site 813009113 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 813009114 ATP binding site [chemical binding]; other site 813009115 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 813009116 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 813009117 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813009118 binding surface 813009119 TPR motif; other site 813009120 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 813009121 EamA-like transporter family; Region: EamA; pfam00892 813009122 EamA-like transporter family; Region: EamA; pfam00892 813009123 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 813009124 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cd01616 813009125 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 813009126 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 813009127 active site 813009128 dimer interface [polypeptide binding]; other site 813009129 motif 1; other site 813009130 motif 2; other site 813009131 motif 3; other site 813009132 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 813009133 anticodon binding site; other site 813009134 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 813009135 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 813009136 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 813009137 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 813009138 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 813009139 active site 813009140 HIGH motif; other site 813009141 dimer interface [polypeptide binding]; other site 813009142 KMSKS motif; other site 813009143 excinuclease ABC subunit B; Provisional; Region: PRK05298 813009144 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813009145 ATP binding site [chemical binding]; other site 813009146 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813009147 nucleotide binding region [chemical binding]; other site 813009148 ATP-binding site [chemical binding]; other site 813009149 Ultra-violet resistance protein B; Region: UvrB; pfam12344 813009150 enolase; Provisional; Region: eno; PRK00077 813009151 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 813009152 dimer interface [polypeptide binding]; other site 813009153 metal binding site [ion binding]; metal-binding site 813009154 substrate binding pocket [chemical binding]; other site 813009155 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 813009156 HAMP domain; Region: HAMP; pfam00672 813009157 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 813009158 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 813009159 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 813009160 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 813009161 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 813009162 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 813009163 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 813009164 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 813009165 active site 813009166 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 813009167 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 813009168 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 813009169 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 813009170 DsbD alpha interface [polypeptide binding]; other site 813009171 catalytic residues [active] 813009172 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 813009173 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 813009174 translocation protein TolB; Provisional; Region: tolB; PRK01029 813009175 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813009176 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813009177 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813009178 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 813009179 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 813009180 ligand binding site [chemical binding]; other site 813009181 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 813009182 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813009183 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 813009184 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 813009185 dimer interface [polypeptide binding]; other site 813009186 decamer (pentamer of dimers) interface [polypeptide binding]; other site 813009187 catalytic triad [active] 813009188 peroxidatic and resolving cysteines [active] 813009189 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 813009190 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 813009191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 813009192 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 813009193 active site 813009194 dimerization interface [polypeptide binding]; other site 813009195 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 813009196 ligand binding site [chemical binding]; other site 813009197 active site 813009198 UGI interface [polypeptide binding]; other site 813009199 catalytic site [active] 813009200 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 813009201 Part of AAA domain; Region: AAA_19; pfam13245 813009202 Family description; Region: UvrD_C_2; pfam13538 813009203 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 813009204 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 813009205 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 813009206 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 813009207 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 813009208 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 813009209 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 813009210 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 813009211 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 813009212 folate binding site [chemical binding]; other site 813009213 NADP+ binding site [chemical binding]; other site 813009214 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 813009215 catalytic center binding site [active] 813009216 ATP binding site [chemical binding]; other site 813009217 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 813009218 dihydropteroate synthase; Region: DHPS; TIGR01496 813009219 substrate binding pocket [chemical binding]; other site 813009220 dimer interface [polypeptide binding]; other site 813009221 inhibitor binding site; inhibition site 813009222 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 813009223 homooctamer interface [polypeptide binding]; other site 813009224 active site 813009225 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 813009226 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 813009227 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 813009228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 813009229 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 813009230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 813009231 DNA binding residues [nucleotide binding] 813009232 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 813009233 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 813009234 Effector from type III secretion system; Region: Effector_1; pfam04518 813009235 Effector from type III secretion system; Region: Effector_1; pfam04518 813009236 Effector from type III secretion system; Region: Effector_1; pfam04518 813009237 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 813009238 MviN-like protein; Region: MVIN; pfam03023 813009239 endonuclease IV; Provisional; Region: PRK01060 813009240 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 813009241 AP (apurinic/apyrimidinic) site pocket; other site 813009242 DNA interaction; other site 813009243 Metal-binding active site; metal-binding site 813009244 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 813009245 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 813009246 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813009247 RNA binding surface [nucleotide binding]; other site 813009248 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 813009249 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 813009250 active site residue [active] 813009251 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 813009252 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 813009253 substrate binding pocket [chemical binding]; other site 813009254 chain length determination region; other site 813009255 substrate-Mg2+ binding site; other site 813009256 catalytic residues [active] 813009257 aspartate-rich region 1; other site 813009258 active site lid residues [active] 813009259 aspartate-rich region 2; other site 813009260 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 813009261 putative trimer interface [polypeptide binding]; other site 813009262 putative CoA binding site [chemical binding]; other site 813009263 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 813009264 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 813009265 DNA binding site [nucleotide binding] 813009266 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 813009267 Thymidylate synthase complementing protein; Region: Thy1; cl03630 813009268 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 813009269 dimer interface [polypeptide binding]; other site 813009270 active site 813009271 aspartate-rich active site metal binding site; other site 813009272 allosteric magnesium binding site [ion binding]; other site 813009273 Schiff base residues; other site 813009274 NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit; Region: nqrA; TIGR01936 813009275 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 813009276 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 813009277 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 813009278 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 813009279 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 813009280 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 813009281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813009282 homodimer interface [polypeptide binding]; other site 813009283 catalytic residue [active] 813009284 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 813009285 Part of AAA domain; Region: AAA_19; pfam13245 813009286 Family description; Region: UvrD_C_2; pfam13538 813009287 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 813009288 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 813009289 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 813009290 active site 813009291 interdomain interaction site; other site 813009292 putative metal-binding site [ion binding]; other site 813009293 nucleotide binding site [chemical binding]; other site 813009294 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 813009295 domain I; other site 813009296 DNA binding groove [nucleotide binding] 813009297 phosphate binding site [ion binding]; other site 813009298 domain II; other site 813009299 domain III; other site 813009300 nucleotide binding site [chemical binding]; other site 813009301 catalytic site [active] 813009302 domain IV; other site 813009303 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813009304 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813009305 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813009306 SWI complex, BAF60b domains; Region: SWIB; smart00151 813009307 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 813009308 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 813009309 FMN binding site [chemical binding]; other site 813009310 active site 813009311 catalytic residues [active] 813009312 substrate binding site [chemical binding]; other site 813009313 Predicted integral membrane protein [Function unknown]; Region: COG0762 813009314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813009315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813009316 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 813009317 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 813009318 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 813009319 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 813009320 AAA domain; Region: AAA_30; pfam13604 813009321 Family description; Region: UvrD_C_2; pfam13538 813009322 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 813009323 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 813009324 Walker A/P-loop; other site 813009325 ATP binding site [chemical binding]; other site 813009326 Q-loop/lid; other site 813009327 ABC transporter signature motif; other site 813009328 Walker B; other site 813009329 D-loop; other site 813009330 H-loop/switch region; other site 813009331 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 813009332 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 813009333 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 813009334 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 813009335 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813009336 RNA binding surface [nucleotide binding]; other site 813009337 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 813009338 active site 813009339 hypothetical protein; Provisional; Region: PRK01064 813009340 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 813009341 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 813009342 DNA Topoisomerase IV; Region: TOP4c; smart00434 813009343 CAP-like domain; other site 813009344 active site 813009345 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 813009346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813009347 ATP binding site [chemical binding]; other site 813009348 Mg2+ binding site [ion binding]; other site 813009349 G-X-G motif; other site 813009350 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 813009351 ATP binding site [chemical binding]; other site 813009352 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 813009353 active site 813009354 putative metal-binding site [ion binding]; other site 813009355 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 813009356 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 813009357 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 813009358 NAD(P) binding pocket [chemical binding]; other site 813009359 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813009360 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 813009361 phosphopeptide binding site; other site 813009362 MARCKS family; Region: MARCKS; pfam02063 813009363 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 813009364 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 813009365 phosphopeptide binding site; other site 813009366 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 813009367 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 813009368 binding surface 813009369 Tetratricopeptide repeat; Region: TPR_16; pfam13432 813009370 TPR motif; other site 813009371 type III secretion system ATPase; Provisional; Region: PRK06315 813009372 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813009373 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 813009374 Walker A motif/ATP binding site; other site 813009375 Walker B motif; other site 813009376 type III secretion system protein; Validated; Region: PRK05933 813009377 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 813009378 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 813009379 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813009380 active site 813009381 ATP binding site [chemical binding]; other site 813009382 substrate binding site [chemical binding]; other site 813009383 activation loop (A-loop); other site 813009384 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 813009385 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813009386 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813009387 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 813009388 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 813009389 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 813009390 ADP binding site [chemical binding]; other site 813009391 phosphagen binding site; other site 813009392 substrate specificity loop; other site 813009393 ribosome recycling factor; Reviewed; Region: frr; PRK00083 813009394 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 813009395 hinge region; other site 813009396 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 813009397 putative nucleotide binding site [chemical binding]; other site 813009398 uridine monophosphate binding site [chemical binding]; other site 813009399 homohexameric interface [polypeptide binding]; other site 813009400 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 813009401 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 813009402 Elongation factor TS; Region: EF_TS; pfam00889 813009403 Elongation factor TS; Region: EF_TS; pfam00889 813009404 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 813009405 rRNA interaction site [nucleotide binding]; other site 813009406 S8 interaction site; other site 813009407 putative laminin-1 binding site; other site 813009408 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 813009409 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 813009410 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 813009411 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 813009412 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 813009413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813009414 TPR motif; other site 813009415 Tetratricopeptide repeat; Region: TPR_16; pfam13432 813009416 binding surface 813009417 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813009418 binding surface 813009419 TPR motif; other site 813009420 TPR repeat; Region: TPR_11; pfam13414 813009421 TPR repeat; Region: TPR_11; pfam13414 813009422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813009423 binding surface 813009424 TPR motif; other site 813009425 TPR repeat; Region: TPR_11; pfam13414 813009426 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 813009427 putative ABC transporter; Region: ycf24; CHL00085 813009428 FeS assembly ATPase SufC; Region: sufC; TIGR01978 813009429 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 813009430 Walker A/P-loop; other site 813009431 ATP binding site [chemical binding]; other site 813009432 Q-loop/lid; other site 813009433 ABC transporter signature motif; other site 813009434 Walker B; other site 813009435 D-loop; other site 813009436 H-loop/switch region; other site 813009437 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 813009438 FeS assembly protein SufD; Region: sufD; TIGR01981 813009439 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 813009440 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 813009441 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813009442 catalytic residue [active] 813009443 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 813009444 ParB-like nuclease domain; Region: ParBc; pfam02195 813009445 KorB domain; Region: KorB; pfam08535 813009446 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813009447 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 813009448 Walker A/P-loop; other site 813009449 ATP binding site [chemical binding]; other site 813009450 Q-loop/lid; other site 813009451 ABC transporter signature motif; other site 813009452 Walker B; other site 813009453 D-loop; other site 813009454 H-loop/switch region; other site 813009455 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813009456 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 813009457 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813009458 Walker A/P-loop; other site 813009459 ATP binding site [chemical binding]; other site 813009460 Q-loop/lid; other site 813009461 ABC transporter signature motif; other site 813009462 Walker B; other site 813009463 D-loop; other site 813009464 H-loop/switch region; other site 813009465 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813009466 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 813009467 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 813009468 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 813009469 Phosphoglycerate kinase; Region: PGK; pfam00162 813009470 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 813009471 substrate binding site [chemical binding]; other site 813009472 hinge regions; other site 813009473 ADP binding site [chemical binding]; other site 813009474 catalytic site [active] 813009475 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 813009476 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 813009477 minor groove reading motif; other site 813009478 helix-hairpin-helix signature motif; other site 813009479 substrate binding pocket [chemical binding]; other site 813009480 active site 813009481 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 813009482 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 813009483 trmE is a tRNA modification GTPase; Region: trmE; cd04164 813009484 G1 box; other site 813009485 GTP/Mg2+ binding site [chemical binding]; other site 813009486 Switch I region; other site 813009487 G2 box; other site 813009488 Switch II region; other site 813009489 G3 box; other site 813009490 G4 box; other site 813009491 G5 box; other site 813009492 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 813009493 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 813009494 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 813009495 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 813009496 ATP binding site [chemical binding]; other site 813009497 putative Mg++ binding site [ion binding]; other site 813009498 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 813009499 Predicted GTPases [General function prediction only]; Region: COG1160 813009500 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 813009501 G1 box; other site 813009502 GTP/Mg2+ binding site [chemical binding]; other site 813009503 Switch I region; other site 813009504 G2 box; other site 813009505 Switch II region; other site 813009506 G3 box; other site 813009507 G4 box; other site 813009508 G5 box; other site 813009509 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 813009510 G1 box; other site 813009511 GTP/Mg2+ binding site [chemical binding]; other site 813009512 Switch I region; other site 813009513 G2 box; other site 813009514 G3 box; other site 813009515 Switch II region; other site 813009516 G4 box; other site 813009517 G5 box; other site 813009518 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 813009519 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 813009520 active site 813009521 NTP binding site [chemical binding]; other site 813009522 metal binding triad [ion binding]; metal-binding site 813009523 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 813009524 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 813009525 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 813009526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813009527 Walker A motif; other site 813009528 ATP binding site [chemical binding]; other site 813009529 Walker B motif; other site 813009530 arginine finger; other site 813009531 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 813009532 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 813009533 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 813009534 oligomer interface [polypeptide binding]; other site 813009535 active site residues [active] 813009536 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 813009537 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 813009538 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813009539 ATP binding site [chemical binding]; other site 813009540 putative Mg++ binding site [ion binding]; other site 813009541 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813009542 nucleotide binding region [chemical binding]; other site 813009543 ATP-binding site [chemical binding]; other site 813009544 rod shape-determining protein MreB; Provisional; Region: PRK13927 813009545 MreB and similar proteins; Region: MreB_like; cd10225 813009546 nucleotide binding site [chemical binding]; other site 813009547 Mg binding site [ion binding]; other site 813009548 putative protofilament interaction site [polypeptide binding]; other site 813009549 RodZ interaction site [polypeptide binding]; other site 813009550 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 813009551 active site 813009552 substrate-binding site [chemical binding]; other site 813009553 metal-binding site [ion binding] 813009554 GTP binding site [chemical binding]; other site 813009555 Effector from type III secretion system; Region: Effector_1; pfam04518 813009556 Effector from type III secretion system; Region: Effector_1; pfam04518 813009557 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 813009558 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 813009559 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 813009560 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 813009561 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 813009562 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 813009563 active site 813009564 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 813009565 type III secretion system ATPase; Validated; Region: PRK05922 813009566 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813009567 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 813009568 Walker A motif; other site 813009569 ATP binding site [chemical binding]; other site 813009570 Walker B motif; other site 813009571 type III secretion system protein; Validated; Region: PRK05934 813009572 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 813009573 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 813009574 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 813009575 active site 813009576 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 813009577 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 813009578 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813009579 catalytic residue [active] 813009580 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 813009581 catalytic core [active] 813009582 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 813009583 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813009584 RNA binding surface [nucleotide binding]; other site 813009585 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 813009586 active site 813009587 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 813009588 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 813009589 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 813009590 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 813009591 motif II; other site 813009592 CCC1-related protein family; Region: CCC1_like_1; cd02437 813009593 seryl-tRNA synthetase; Provisional; Region: PRK05431 813009594 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 813009595 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 813009596 dimer interface [polypeptide binding]; other site 813009597 active site 813009598 motif 1; other site 813009599 motif 2; other site 813009600 motif 3; other site 813009601 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 813009602 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 813009603 catalytic motif [active] 813009604 Zn binding site [ion binding]; other site 813009605 RibD C-terminal domain; Region: RibD_C; pfam01872 813009606 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 813009607 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 813009608 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 813009609 dimerization interface [polypeptide binding]; other site 813009610 active site 813009611 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 813009612 homopentamer interface [polypeptide binding]; other site 813009613 active site 813009614 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 813009615 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 813009616 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 813009617 substrate binding site [chemical binding]; other site 813009618 Proteins containing SET domain [General function prediction only]; Region: COG2940 813009619 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 813009620 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 813009621 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 813009622 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 813009623 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 813009624 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 813009625 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 813009626 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 813009627 catalytic loop [active] 813009628 iron binding site [ion binding]; other site 813009629 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 813009630 FAD binding pocket [chemical binding]; other site 813009631 FAD binding motif [chemical binding]; other site 813009632 phosphate binding motif [ion binding]; other site 813009633 beta-alpha-beta structure motif; other site 813009634 NAD binding pocket [chemical binding]; other site 813009635 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 813009636 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 813009637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813009638 S-adenosylmethionine binding site [chemical binding]; other site 813009639 Histone H1-like protein Hc1; Region: Hc1; pfam07432 813009640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813009641 binding surface 813009642 TPR motif; other site 813009643 Tetratricopeptide repeat; Region: TPR_12; pfam13424 813009644 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 813009645 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 813009646 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 813009647 substrate binding site [chemical binding]; other site 813009648 active site 813009649 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 813009650 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 813009651 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813009652 ATP binding site [chemical binding]; other site 813009653 putative Mg++ binding site [ion binding]; other site 813009654 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813009655 nucleotide binding region [chemical binding]; other site 813009656 ATP-binding site [chemical binding]; other site 813009657 TRCF domain; Region: TRCF; pfam03461 813009658 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 813009659 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 813009660 motif 1; other site 813009661 active site 813009662 motif 2; other site 813009663 motif 3; other site 813009664 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 813009665 DHHA1 domain; Region: DHHA1; pfam02272 813009666 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 813009667 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 813009668 TPP-binding site [chemical binding]; other site 813009669 dimer interface [polypeptide binding]; other site 813009670 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 813009671 PYR/PP interface [polypeptide binding]; other site 813009672 dimer interface [polypeptide binding]; other site 813009673 TPP binding site [chemical binding]; other site 813009674 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813009675 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 813009676 elongation factor P; Validated; Region: PRK00529 813009677 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 813009678 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 813009679 RNA binding site [nucleotide binding]; other site 813009680 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 813009681 RNA binding site [nucleotide binding]; other site 813009682 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813009683 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 813009684 putative active site [active] 813009685 putative metal binding site [ion binding]; other site 813009686 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 813009687 active site 813009688 metal binding site [ion binding]; metal-binding site 813009689 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 813009690 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 813009691 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 813009692 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813009693 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813009694 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 813009695 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 813009696 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813009697 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813009698 cell division protein FtsW; Region: ftsW; TIGR02614 813009699 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 813009700 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 813009701 active site 813009702 homodimer interface [polypeptide binding]; other site 813009703 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 813009704 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409 813009705 G-X-X-G motif; other site 813009706 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 813009707 anti sigma factor interaction site; other site 813009708 regulatory phosphorylation site [posttranslational modification]; other site 813009709 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 813009710 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 813009711 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813009712 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 813009713 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 813009714 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 813009715 dimer interface [polypeptide binding]; other site 813009716 active site 813009717 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 813009718 active site 813009719 Ap4A binding cleft/pocket [chemical binding]; other site 813009720 P4 phosphate binding site; other site 813009721 nudix motif; other site 813009722 putative P2/P3 phosphate binding site [ion binding]; other site 813009723 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 813009724 dimer interface [polypeptide binding]; other site 813009725 substrate binding site [chemical binding]; other site 813009726 metal binding sites [ion binding]; metal-binding site 813009727 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 813009728 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 813009729 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 813009730 NAD binding site [chemical binding]; other site 813009731 Phe binding site; other site 813009732 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 813009733 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 813009734 active site 813009735 putative lithium-binding site [ion binding]; other site 813009736 substrate binding site [chemical binding]; other site 813009737 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 813009738 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 813009739 putative acyl-acceptor binding pocket; other site 813009740 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 813009741 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 813009742 acyl-activating enzyme (AAE) consensus motif; other site 813009743 AMP binding site [chemical binding]; other site 813009744 active site 813009745 CoA binding site [chemical binding]; other site 813009746 8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937 813009747 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 813009748 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813009749 catalytic residue [active] 813009750 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 813009751 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813009752 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 813009753 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 813009754 dimer interface [polypeptide binding]; other site 813009755 putative anticodon binding site; other site 813009756 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813009757 motif 1; other site 813009758 dimer interface [polypeptide binding]; other site 813009759 active site 813009760 motif 2; other site 813009761 motif 3; other site 813009762 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 813009763 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 813009764 active site 813009765 HIGH motif; other site 813009766 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 813009767 KMSKS motif; other site 813009768 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813009769 tRNA binding surface [nucleotide binding]; other site 813009770 anticodon binding site; other site 813009771 ribonuclease P; Reviewed; Region: rnpA; PRK00730 813009772 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 813009773 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 813009774 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 813009775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 813009776 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 813009777 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 813009778 GIY-YIG motif/motif A; other site 813009779 active site 813009780 catalytic site [active] 813009781 putative DNA binding site [nucleotide binding]; other site 813009782 metal binding site [ion binding]; metal-binding site 813009783 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 813009784 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 813009785 MutS domain I; Region: MutS_I; pfam01624 813009786 MutS domain II; Region: MutS_II; pfam05188 813009787 MutS domain III; Region: MutS_III; pfam05192 813009788 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 813009789 Walker A/P-loop; other site 813009790 ATP binding site [chemical binding]; other site 813009791 Q-loop/lid; other site 813009792 ABC transporter signature motif; other site 813009793 Walker B; other site 813009794 D-loop; other site 813009795 H-loop/switch region; other site 813009796 DNA primase; Validated; Region: dnaG; PRK05667 813009797 CHC2 zinc finger; Region: zf-CHC2; pfam01807 813009798 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 813009799 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 813009800 active site 813009801 metal binding site [ion binding]; metal-binding site 813009802 interdomain interaction site; other site 813009803 glycyl-tRNA synthetase; Provisional; Region: PRK14908 813009804 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 813009805 dimer interface [polypeptide binding]; other site 813009806 motif 1; other site 813009807 active site 813009808 motif 2; other site 813009809 motif 3; other site 813009810 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813009811 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 813009812 glycogen synthase; Provisional; Region: glgA; PRK00654 813009813 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 813009814 ADP-binding pocket [chemical binding]; other site 813009815 homodimer interface [polypeptide binding]; other site 813009816 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 813009817 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 813009818 5S rRNA interface [nucleotide binding]; other site 813009819 CTC domain interface [polypeptide binding]; other site 813009820 L16 interface [polypeptide binding]; other site 813009821 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 813009822 putative active site [active] 813009823 catalytic residue [active] 813009824 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 813009825 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 813009826 Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359 813009827 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 813009828 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 813009829 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 813009830 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 813009831 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 813009832 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813009833 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813009834 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 813009835 putative acyl-acceptor binding pocket; other site 813009836 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 813009837 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 813009838 homodimer interface [polypeptide binding]; other site 813009839 oligonucleotide binding site [chemical binding]; other site 813009840 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 813009841 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 813009842 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813009843 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813009844 YtxH-like protein; Region: YtxH; cl02079 813009845 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 813009846 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 813009847 active site 813009848 substrate binding site [chemical binding]; other site 813009849 metal binding site [ion binding]; metal-binding site 813009850 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 813009851 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 813009852 glutaminase active site [active] 813009853 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 813009854 dimer interface [polypeptide binding]; other site 813009855 active site 813009856 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 813009857 dimer interface [polypeptide binding]; other site 813009858 active site 813009859 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 813009860 aromatic amino acid transport protein; Region: araaP; TIGR00837 813009861 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 813009862 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 813009863 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 813009864 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 813009865 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 813009866 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 813009867 CoA binding domain; Region: CoA_binding; smart00881 813009868 CoA-ligase; Region: Ligase_CoA; pfam00549 813009869 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 813009870 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 813009871 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 813009872 protein binding site [polypeptide binding]; other site 813009873 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 813009874 protein binding site [polypeptide binding]; other site 813009875 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 813009876 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 813009877 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813009878 Peptidase M16C associated; Region: M16C_assoc; pfam08367 813009879 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813009880 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 813009881 RmuC family; Region: RmuC; pfam02646 813009882 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 813009883 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 813009884 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 813009885 ATP cone domain; Region: ATP-cone; pfam03477 813009886 ATP cone domain; Region: ATP-cone; pfam03477 813009887 Class I ribonucleotide reductase; Region: RNR_I; cd01679 813009888 active site 813009889 dimer interface [polypeptide binding]; other site 813009890 catalytic residues [active] 813009891 effector binding site; other site 813009892 R2 peptide binding site; other site 813009893 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 813009894 dimer interface [polypeptide binding]; other site 813009895 putative radical transfer pathway; other site 813009896 diiron center [ion binding]; other site 813009897 tyrosyl radical; other site 813009898 Putative methyltransferase; Region: Methyltransf_4; pfam02390 813009899 Methyltransferase domain; Region: Methyltransf_18; pfam12847 813009900 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 813009901 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 813009902 FAD binding domain; Region: FAD_binding_4; pfam01565 813009903 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 813009904 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 813009905 putative RNA binding site [nucleotide binding]; other site 813009906 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 813009907 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 813009908 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 813009909 Ribosomal protein L35 [Translation, ribosomal structure and biogenesis]; Region: RpmI; COG0291 813009910 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 813009911 23S rRNA binding site [nucleotide binding]; other site 813009912 L21 binding site [polypeptide binding]; other site 813009913 L13 binding site [polypeptide binding]; other site 813009914 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 813009915 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 813009916 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 813009917 motif 1; other site 813009918 dimer interface [polypeptide binding]; other site 813009919 active site 813009920 motif 2; other site 813009921 motif 3; other site 813009922 Predicted permeases [General function prediction only]; Region: COG0795 813009923 Predicted permeases [General function prediction only]; Region: COG0795 813009924 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 813009925 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 813009926 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 813009927 Ligand Binding Site [chemical binding]; other site 813009928 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 813009929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813009930 Walker A motif; other site 813009931 ATP binding site [chemical binding]; other site 813009932 Walker B motif; other site 813009933 arginine finger; other site 813009934 Peptidase family M41; Region: Peptidase_M41; pfam01434 813009935 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 813009936 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 813009937 RNase E interface [polypeptide binding]; other site 813009938 trimer interface [polypeptide binding]; other site 813009939 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 813009940 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 813009941 RNase E interface [polypeptide binding]; other site 813009942 trimer interface [polypeptide binding]; other site 813009943 active site 813009944 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 813009945 putative nucleic acid binding region [nucleotide binding]; other site 813009946 G-X-X-G motif; other site 813009947 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 813009948 RNA binding site [nucleotide binding]; other site 813009949 domain interface; other site 813009950 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 813009951 16S/18S rRNA binding site [nucleotide binding]; other site 813009952 S13e-L30e interaction site [polypeptide binding]; other site 813009953 25S rRNA binding site [nucleotide binding]; other site 813009954 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 813009955 nucleoside/Zn binding site; other site 813009956 dimer interface [polypeptide binding]; other site 813009957 catalytic motif [active] 813009958 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813009959 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813009960 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813009961 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813009962 methionine aminopeptidase; Provisional; Region: PRK12318 813009963 SEC-C motif; Region: SEC-C; pfam02810 813009964 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 813009965 active site 813009966 MarC family integral membrane protein; Region: MarC; pfam01914 813009967 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 813009968 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 813009969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813009970 dimer interface [polypeptide binding]; other site 813009971 conserved gate region; other site 813009972 putative PBP binding loops; other site 813009973 ABC-ATPase subunit interface; other site 813009974 NMT1/THI5 like; Region: NMT1; pfam09084 813009975 fumarate hydratase, class II; Region: fumC_II; TIGR00979 813009976 Class II fumarases; Region: Fumarase_classII; cd01362 813009977 active site 813009978 tetramer interface [polypeptide binding]; other site 813009979 high affinity sulphate transporter 1; Region: sulP; TIGR00815 813009980 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 813009981 Sulfate transporter family; Region: Sulfate_transp; pfam00916 813009982 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 813009983 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 813009984 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 813009985 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 813009986 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 813009987 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 813009988 active site triad [active] 813009989 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 813009990 LytB protein; Region: LYTB; pfam02401 813009991 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 813009992 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 813009993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813009994 binding surface 813009995 TPR motif; other site 813009996 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 813009997 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 813009998 active site 813009999 DNA binding site [nucleotide binding] 813010000 Int/Topo IB signature motif; other site 813010001 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 813010002 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 813010003 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813010004 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813010005 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813010006 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813010007 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813010008 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813010009 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813010010 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813010011 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813010012 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813010013 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813010014 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813010015 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813010016 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813010017 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813010018 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813010019 Uncharacterized conserved protein [Function unknown]; Region: COG2155 813010020 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 813010021 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 813010022 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 813010023 ribonuclease HIII; Region: rnhC; TIGR00716 813010024 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 813010025 RNA/DNA hybrid binding site [nucleotide binding]; other site 813010026 active site 813010027 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 813010028 Helix-turn-helix domain; Region: HTH_25; pfam13413 813010029 Uncharacterized conserved protein [Function unknown]; Region: COG1624 813010030 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 813010031 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 813010032 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 813010033 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 813010034 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 813010035 putative active site [active] 813010036 PhoH-like protein; Region: PhoH; pfam02562 813010037 peptide chain release factor 1; Validated; Region: prfA; PRK00591 813010038 PCRF domain; Region: PCRF; pfam03462 813010039 RF-1 domain; Region: RF-1; pfam00472 813010040 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 813010041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813010042 S-adenosylmethionine binding site [chemical binding]; other site 813010043 signal recognition particle protein; Provisional; Region: PRK10867 813010044 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 813010045 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 813010046 P loop; other site 813010047 GTP binding site [chemical binding]; other site 813010048 Signal peptide binding domain; Region: SRP_SPB; pfam02978 813010049 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 813010050 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 813010051 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 813010052 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 813010053 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 813010054 RNA/DNA hybrid binding site [nucleotide binding]; other site 813010055 active site 813010056 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 813010057 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 813010058 catalytic site [active] 813010059 G-X2-G-X-G-K; other site 813010060 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 813010061 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 813010062 active site 813010063 HIGH motif; other site 813010064 KMSKS motif; other site 813010065 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 813010066 tRNA binding surface [nucleotide binding]; other site 813010067 anticodon binding site; other site 813010068 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 813010069 AAA domain; Region: AAA_30; pfam13604 813010070 Family description; Region: UvrD_C_2; pfam13538 813010071 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 813010072 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 813010073 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 813010074 conserved cys residue [active] 813010075 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 813010076 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 813010077 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 813010078 trimer interface [polypeptide binding]; other site 813010079 active site 813010080 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 813010081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813010082 Walker A motif; other site 813010083 ATP binding site [chemical binding]; other site 813010084 Walker B motif; other site 813010085 arginine finger; other site 813010086 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 813010087 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813010088 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 813010089 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 813010090 dimer interface [polypeptide binding]; other site 813010091 ssDNA binding site [nucleotide binding]; other site 813010092 tetramer (dimer of dimers) interface [polypeptide binding]; other site 813010093 hypothetical protein; Provisional; Region: PRK05907 813010094 Predicted methyltransferases [General function prediction only]; Region: COG0313 813010095 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 813010096 putative SAM binding site [chemical binding]; other site 813010097 homodimer interface [polypeptide binding]; other site 813010098 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 813010099 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813010100 FeS/SAM binding site; other site 813010101 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 813010102 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 813010103 catalytic loop [active] 813010104 iron binding site [ion binding]; other site 813010105 type III secretion system protein; Validated; Region: PRK05910 813010106 FHIPEP family; Region: FHIPEP; pfam00771 813010107 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 813010108 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 813010109 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 813010110 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 813010111 DNA binding residues [nucleotide binding] 813010112 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 813010113 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 813010114 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 813010115 ADP/ATP carrier protein family; Region: AAA; TIGR00769 813010116 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813010117 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813010118 ABC-ATPase subunit interface; other site 813010119 dimer interface [polypeptide binding]; other site 813010120 putative PBP binding regions; other site 813010121 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 813010122 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 813010123 DNA polymerase III subunit beta; Validated; Region: PRK05643 813010124 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 813010125 putative DNA binding surface [nucleotide binding]; other site 813010126 dimer interface [polypeptide binding]; other site 813010127 beta-clamp/clamp loader binding surface; other site 813010128 beta-clamp/translesion DNA polymerase binding surface; other site 813010129 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 813010130 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 813010131 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 813010132 homodimer interface [polypeptide binding]; other site 813010133 NADP binding site [chemical binding]; other site 813010134 substrate binding site [chemical binding]; other site 813010135 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 813010136 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813010137 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 813010138 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 813010139 RNA binding site [nucleotide binding]; other site 813010140 active site 813010141 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 813010142 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 813010143 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 813010144 RNA binding site [nucleotide binding]; other site 813010145 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 813010146 RNA binding site [nucleotide binding]; other site 813010147 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813010148 RNA binding site [nucleotide binding]; other site 813010149 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813010150 RNA binding site [nucleotide binding]; other site 813010151 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 813010152 RNA binding site [nucleotide binding]; other site 813010153 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 813010154 RNA binding site [nucleotide binding]; other site 813010155 domain interface; other site 813010156 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 813010157 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 813010158 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 813010159 NAD binding site [chemical binding]; other site 813010160 homotetramer interface [polypeptide binding]; other site 813010161 homodimer interface [polypeptide binding]; other site 813010162 substrate binding site [chemical binding]; other site 813010163 active site 813010164 Uncharacterized conserved protein [Function unknown]; Region: COG0327 813010165 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 813010166 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 813010167 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 813010168 ring oligomerisation interface [polypeptide binding]; other site 813010169 ATP/Mg binding site [chemical binding]; other site 813010170 stacking interactions; other site 813010171 hinge regions; other site 813010172 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 813010173 oligomerisation interface [polypeptide binding]; other site 813010174 mobile loop; other site 813010175 roof hairpin; other site 813010176 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 813010177 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 813010178 active site 813010179 Zn binding site [ion binding]; other site 813010180 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 813010181 Clp amino terminal domain; Region: Clp_N; pfam02861 813010182 Clp amino terminal domain; Region: Clp_N; pfam02861 813010183 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813010184 Walker A motif; other site 813010185 ATP binding site [chemical binding]; other site 813010186 Walker B motif; other site 813010187 arginine finger; other site 813010188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813010189 Walker A motif; other site 813010190 ATP binding site [chemical binding]; other site 813010191 Walker B motif; other site 813010192 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 813010193 Uncharacterized conserved protein [Function unknown]; Region: COG2912 813010194 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 813010195 elongation factor P; Provisional; Region: PRK12426 813010196 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813010197 RNA binding site [nucleotide binding]; other site 813010198 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 813010199 RNA binding site [nucleotide binding]; other site 813010200 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 813010201 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 813010202 carboxyltransferase (CT) interaction site; other site 813010203 biotinylation site [posttranslational modification]; other site 813010204 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 813010205 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 813010206 ATP-grasp domain; Region: ATP-grasp_4; cl17255 813010207 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 813010208 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 813010209 23S rRNA interface [nucleotide binding]; other site 813010210 L3 interface [polypeptide binding]; other site 813010211 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 813010212 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 813010213 NlpC/P60 family; Region: NLPC_P60; cl17555 813010214 adenylate kinase; Reviewed; Region: adk; PRK00279 813010215 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 813010216 AMP-binding site [chemical binding]; other site 813010217 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 813010218 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 813010219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813010220 dimer interface [polypeptide binding]; other site 813010221 conserved gate region; other site 813010222 putative PBP binding loops; other site 813010223 ABC-ATPase subunit interface; other site 813010224 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 813010225 Methyltransferase domain; Region: Methyltransf_23; pfam13489 813010226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813010227 S-adenosylmethionine binding site [chemical binding]; other site 813010228 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 813010229 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 813010230 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 813010231 active site 813010232 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 813010233 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 813010234 conserved hypothetical integral membrane protein; Region: TIGR00697 813010235 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 813010236 SEC-C motif; Region: SEC-C; pfam02810 813010237 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 813010238 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813010239 active site 813010240 ATP binding site [chemical binding]; other site 813010241 substrate binding site [chemical binding]; other site 813010242 activation loop (A-loop); other site 813010243 Uncharacterized conserved protein [Function unknown]; Region: COG1262 813010244 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 813010245 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 813010246 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 813010247 nucleotide binding pocket [chemical binding]; other site 813010248 K-X-D-G motif; other site 813010249 catalytic site [active] 813010250 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 813010251 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 813010252 Helix-hairpin-helix motif; Region: HHH; pfam00633 813010253 helix-hairpin-helix signature motif; other site 813010254 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 813010255 Dimer interface [polypeptide binding]; other site 813010256 BRCT sequence motif; other site 813010257 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 813010258 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 813010259 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 813010260 FtsX-like permease family; Region: FtsX; pfam02687 813010261 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 813010262 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 813010263 Walker A/P-loop; other site 813010264 ATP binding site [chemical binding]; other site 813010265 Q-loop/lid; other site 813010266 ABC transporter signature motif; other site 813010267 Walker B; other site 813010268 D-loop; other site 813010269 H-loop/switch region; other site 813010270 membrane-attack complex / perforin; Region: MACPF; smart00457 813010271 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 813010272 Trp repressor protein; Region: Trp_repressor; cl17266 813010273 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 813010274 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 813010275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813010276 catalytic residue [active] 813010277 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 813010278 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 813010279 substrate binding site [chemical binding]; other site 813010280 active site 813010281 catalytic residues [active] 813010282 heterodimer interface [polypeptide binding]; other site 813010283 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 813010284 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 813010285 peptide binding site [polypeptide binding]; other site 813010286 putative disulfide oxidoreductase; Provisional; Region: PRK00611 813010287 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 813010288 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 813010289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813010290 Walker A/P-loop; other site 813010291 ATP binding site [chemical binding]; other site 813010292 Q-loop/lid; other site 813010293 ABC transporter signature motif; other site 813010294 Walker B; other site 813010295 D-loop; other site 813010296 H-loop/switch region; other site 813010297 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 813010298 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 813010299 Ligand binding site; other site 813010300 oligomer interface; other site 813010301 CTP synthetase; Validated; Region: pyrG; PRK05380 813010302 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 813010303 Catalytic site [active] 813010304 active site 813010305 UTP binding site [chemical binding]; other site 813010306 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 813010307 active site 813010308 putative oxyanion hole; other site 813010309 catalytic triad [active] 813010310 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 813010311 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 813010312 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 813010313 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 813010314 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 813010315 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 813010316 putative active site [active] 813010317 DNA polymerase III subunit delta'; Validated; Region: PRK05917 813010318 DNA polymerase III subunit delta'; Validated; Region: PRK08485 813010319 thymidylate kinase; Validated; Region: tmk; PRK00698 813010320 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 813010321 TMP-binding site; other site 813010322 ATP-binding site [chemical binding]; other site 813010323 DNA gyrase, A subunit; Region: gyrA; TIGR01063 813010324 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 813010325 CAP-like domain; other site 813010326 active site 813010327 primary dimer interface [polypeptide binding]; other site 813010328 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813010329 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813010330 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813010331 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813010332 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813010333 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813010334 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 813010335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813010336 ATP binding site [chemical binding]; other site 813010337 Mg2+ binding site [ion binding]; other site 813010338 G-X-G motif; other site 813010339 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 813010340 anchoring element; other site 813010341 dimer interface [polypeptide binding]; other site 813010342 ATP binding site [chemical binding]; other site 813010343 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 813010344 active site 813010345 putative metal-binding site [ion binding]; other site 813010346 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 813010347 Protein of unknown function (DUF721); Region: DUF721; pfam05258 813010348 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 813010349 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 813010350 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 813010351 MgtE intracellular N domain; Region: MgtE_N; pfam03448 813010352 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 813010353 Divalent cation transporter; Region: MgtE; pfam01769 813010354 UGMP family protein; Validated; Region: PRK09604 813010355 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 813010356 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 813010357 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 813010358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813010359 dimer interface [polypeptide binding]; other site 813010360 conserved gate region; other site 813010361 putative PBP binding loops; other site 813010362 ABC-ATPase subunit interface; other site 813010363 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 813010364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813010365 dimer interface [polypeptide binding]; other site 813010366 conserved gate region; other site 813010367 putative PBP binding loops; other site 813010368 ABC-ATPase subunit interface; other site 813010369 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 813010370 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813010371 Walker A/P-loop; other site 813010372 ATP binding site [chemical binding]; other site 813010373 Q-loop/lid; other site 813010374 ABC transporter signature motif; other site 813010375 Walker B; other site 813010376 D-loop; other site 813010377 H-loop/switch region; other site 813010378 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813010379 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 813010380 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 813010381 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 813010382 transmembrane helices; other site 813010383 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 813010384 active site 813010385 ADP/pyrophosphate binding site [chemical binding]; other site 813010386 dimerization interface [polypeptide binding]; other site 813010387 allosteric effector site; other site 813010388 fructose-1,6-bisphosphate binding site; other site 813010389 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 813010390 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 813010391 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 813010392 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 813010393 active site 813010394 ADP/pyrophosphate binding site [chemical binding]; other site 813010395 dimerization interface [polypeptide binding]; other site 813010396 allosteric effector site; other site 813010397 fructose-1,6-bisphosphate binding site; other site 813010398 Uncharacterized conserved protein [Function unknown]; Region: COG1259 813010399 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 813010400 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 813010401 prenyltransferase; Reviewed; Region: ubiA; PRK12876 813010402 UbiA prenyltransferase family; Region: UbiA; pfam01040 813010403 acyl carrier protein; Provisional; Region: acpP; PRK00982 813010404 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 813010405 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 813010406 NAD(P) binding site [chemical binding]; other site 813010407 homotetramer interface [polypeptide binding]; other site 813010408 homodimer interface [polypeptide binding]; other site 813010409 active site 813010410 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 813010411 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 813010412 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 813010413 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 813010414 dimer interface [polypeptide binding]; other site 813010415 active site 813010416 CoA binding pocket [chemical binding]; other site 813010417 recombination protein RecR; Region: recR; TIGR00615 813010418 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 813010419 putative active site [active] 813010420 putative metal-binding site [ion binding]; other site 813010421 tetramer interface [polypeptide binding]; other site 813010422 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 813010423 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 813010424 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 813010425 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 813010426 trimer interface [polypeptide binding]; other site 813010427 active site 813010428 UDP-GlcNAc binding site [chemical binding]; other site 813010429 lipid binding site [chemical binding]; lipid-binding site 813010430 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 813010431 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 813010432 tetramer interface [polypeptide binding]; other site 813010433 TPP-binding site [chemical binding]; other site 813010434 heterodimer interface [polypeptide binding]; other site 813010435 phosphorylation loop region [posttranslational modification] 813010436 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 813010437 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813010438 E3 interaction surface; other site 813010439 lipoyl attachment site [posttranslational modification]; other site 813010440 e3 binding domain; Region: E3_binding; pfam02817 813010441 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813010442 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 813010443 homodimer interface [polypeptide binding]; other site 813010444 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 813010445 active site pocket [active] 813010446 chromosomal replication initiation protein; Provisional; Region: PRK12422 813010447 DnaA N-terminal domain; Region: DnaA_N; pfam11638 813010448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813010449 Walker A motif; other site 813010450 ATP binding site [chemical binding]; other site 813010451 Walker B motif; other site 813010452 arginine finger; other site 813010453 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 813010454 DnaA box-binding interface [nucleotide binding]; other site 813010455 CAAX protease self-immunity; Region: Abi; pfam02517 813010456 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 813010457 homodimer interface [polypeptide binding]; other site 813010458 metal binding site [ion binding]; metal-binding site 813010459 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 813010460 Domain of unknown function DUF21; Region: DUF21; pfam01595 813010461 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813010462 Transporter associated domain; Region: CorC_HlyC; smart01091 813010463 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 813010464 Domain of unknown function DUF21; Region: DUF21; pfam01595 813010465 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813010466 Transporter associated domain; Region: CorC_HlyC; smart01091 813010467 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 813010468 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 813010469 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813010470 catalytic residue [active] 813010471 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 813010472 Protein phosphatase 2C; Region: PP2C; pfam00481 813010473 active site 813010474 Uncharacterized conserved protein [Function unknown]; Region: COG5465 813010475 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 813010476 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 813010477 active site 813010478 catalytic site [active] 813010479 substrate binding site [chemical binding]; other site 813010480 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 813010481 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 813010482 nucleosidase; Provisional; Region: PRK05634 813010483 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 813010484 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 813010485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813010486 Walker A/P-loop; other site 813010487 ATP binding site [chemical binding]; other site 813010488 Q-loop/lid; other site 813010489 ABC transporter signature motif; other site 813010490 Walker B; other site 813010491 D-loop; other site 813010492 H-loop/switch region; other site 813010493 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 813010494 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 813010495 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 813010496 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 813010497 active site 813010498 metal binding site [ion binding]; metal-binding site 813010499 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 813010500 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 813010501 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813010502 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813010503 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 813010504 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 813010505 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 813010506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813010507 TPR motif; other site 813010508 binding surface 813010509 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 813010510 DnaA N-terminal domain; Region: DnaA_N; pfam11638 813010511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813010512 Walker A motif; other site 813010513 ATP binding site [chemical binding]; other site 813010514 Walker B motif; other site 813010515 arginine finger; other site 813010516 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 813010517 DnaA box-binding interface [nucleotide binding]; other site 813010518 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 813010519 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 813010520 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 813010521 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 813010522 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 813010523 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 813010524 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 813010525 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 813010526 lipoyl attachment site [posttranslational modification]; other site 813010527 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 813010528 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 813010529 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813010530 putative active site [active] 813010531 catalytic site [active] 813010532 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813010533 putative active site [active] 813010534 catalytic site [active] 813010535 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 813010536 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 813010537 Clp amino terminal domain; Region: Clp_N; pfam02861 813010538 Clp amino terminal domain; Region: Clp_N; pfam02861 813010539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813010540 Walker A motif; other site 813010541 ATP binding site [chemical binding]; other site 813010542 Walker B motif; other site 813010543 arginine finger; other site 813010544 UvrB/uvrC motif; Region: UVR; pfam02151 813010545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813010546 Walker A motif; other site 813010547 ATP binding site [chemical binding]; other site 813010548 Walker B motif; other site 813010549 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 813010550 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 813010551 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 813010552 Ligand Binding Site [chemical binding]; other site 813010553 Helix-turn-helix domain; Region: HTH_17; pfam12728 813010554 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 813010555 active site 813010556 phosphorylation site [posttranslational modification] 813010557 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 813010558 active site 813010559 phosphorylation site [posttranslational modification] 813010560 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 813010561 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 813010562 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 813010563 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 813010564 active site 813010565 substrate binding site [chemical binding]; other site 813010566 metal binding site [ion binding]; metal-binding site 813010567 ribonuclease III; Reviewed; Region: rnc; PRK00102 813010568 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 813010569 dimerization interface [polypeptide binding]; other site 813010570 active site 813010571 metal binding site [ion binding]; metal-binding site 813010572 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 813010573 dsRNA binding site [nucleotide binding]; other site 813010574 DNA repair protein RadA; Provisional; Region: PRK11823 813010575 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 813010576 Walker A motif/ATP binding site; other site 813010577 ATP binding site [chemical binding]; other site 813010578 Walker B motif; other site 813010579 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 813010580 porphobilinogen deaminase; Provisional; Region: PRK01066 813010581 Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379 813010582 V-type ATP synthase subunit K; Provisional; Region: PRK09621 813010583 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 813010584 V-type ATP synthase subunit D; Provisional; Region: PRK02195 813010585 V-type ATP synthase subunit B; Provisional; Region: PRK02118 813010586 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813010587 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 813010588 Walker A motif homologous position; other site 813010589 Walker B motif; other site 813010590 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 813010591 V-type ATP synthase subunit E; Provisional; Region: PRK01005 813010592 V-type ATP synthase subunit E; Provisional; Region: PRK01558 813010593 transaldolase-like protein; Provisional; Region: PTZ00411 813010594 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 813010595 active site 813010596 dimer interface [polypeptide binding]; other site 813010597 catalytic residue [active] 813010598 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 813010599 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 813010600 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 813010601 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 813010602 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 813010603 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 813010604 RPB12 interaction site [polypeptide binding]; other site 813010605 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 813010606 RPB3 interaction site [polypeptide binding]; other site 813010607 RPB1 interaction site [polypeptide binding]; other site 813010608 RPB11 interaction site [polypeptide binding]; other site 813010609 RPB10 interaction site [polypeptide binding]; other site 813010610 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 813010611 L11 interface [polypeptide binding]; other site 813010612 putative EF-Tu interaction site [polypeptide binding]; other site 813010613 putative EF-G interaction site [polypeptide binding]; other site 813010614 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 813010615 mRNA/rRNA interface [nucleotide binding]; other site 813010616 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 813010617 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 813010618 putative thiostrepton binding site; other site 813010619 23S rRNA interface [nucleotide binding]; other site 813010620 L7/L12 interface [polypeptide binding]; other site 813010621 L25 interface [polypeptide binding]; other site 813010622 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 813010623 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 813010624 putative homodimer interface [polypeptide binding]; other site 813010625 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 813010626 heterodimer interface [polypeptide binding]; other site 813010627 homodimer interface [polypeptide binding]; other site 813010628 elongation factor Tu; Reviewed; Region: PRK12735 813010629 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 813010630 G1 box; other site 813010631 GEF interaction site [polypeptide binding]; other site 813010632 GTP/Mg2+ binding site [chemical binding]; other site 813010633 Switch I region; other site 813010634 G2 box; other site 813010635 G3 box; other site 813010636 Switch II region; other site 813010637 G4 box; other site 813010638 G5 box; other site 813010639 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 813010640 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 813010641 Antibiotic Binding Site [chemical binding]; other site 813010642 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 813010643 rRNA binding site [nucleotide binding]; other site 813010644 predicted 30S ribosome binding site; other site 813010645 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 813010646 Protein of unknown function (DUF687); Region: DUF687; pfam05095 813010647 Protein of unknown function (DUF687); Region: DUF687; pfam05095 813010648 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 813010649 active site 813010650 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 813010651 triosephosphate isomerase; Provisional; Region: PRK14565 813010652 substrate binding site [chemical binding]; other site 813010653 dimer interface [polypeptide binding]; other site 813010654 catalytic triad [active] 813010655 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 813010656 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 813010657 generic binding surface II; other site 813010658 generic binding surface I; other site 813010659 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 813010660 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 813010661 pyruvate kinase; Region: pyruv_kin; TIGR01064 813010662 domain interfaces; other site 813010663 active site 813010664 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 813010665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813010666 Walker A motif; other site 813010667 ATP binding site [chemical binding]; other site 813010668 Walker B motif; other site 813010669 arginine finger; other site 813010670 hypothetical protein; Validated; Region: PRK00153 813010671 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 813010672 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 813010673 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 813010674 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 813010675 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 813010676 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 813010677 Glycoprotease family; Region: Peptidase_M22; pfam00814 813010678 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 813010679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813010680 Walker A motif; other site 813010681 ATP binding site [chemical binding]; other site 813010682 Walker B motif; other site 813010683 arginine finger; other site 813010684 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 813010685 ribonuclease Z; Region: RNase_Z; TIGR02651 813010686 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 813010687 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 813010688 active site 813010689 Int/Topo IB signature motif; other site 813010690 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 813010691 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813010692 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813010693 ABC transporter; Region: ABC_tran_2; pfam12848 813010694 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813010695 Maf-like protein; Region: Maf; pfam02545 813010696 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 813010697 active site 813010698 dimer interface [polypeptide binding]; other site 813010699 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 813010700 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 813010701 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 813010702 active site 813010703 catalytic residues [active] 813010704 metal binding site [ion binding]; metal-binding site 813010705 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 813010706 aspartate kinase; Provisional; Region: PRK05925 813010707 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 813010708 putative catalytic residues [active] 813010709 nucleotide binding site [chemical binding]; other site 813010710 aspartate binding site [chemical binding]; other site 813010711 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 813010712 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 813010713 active site 813010714 catalytic residue [active] 813010715 dimer interface [polypeptide binding]; other site 813010716 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 813010717 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 813010718 shikimate binding site; other site 813010719 NAD(P) binding site [chemical binding]; other site 813010720 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 813010721 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 813010722 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 813010723 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 813010724 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 813010725 malate dehydrogenase; Provisional; Region: PRK05442 813010726 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 813010727 NAD(P) binding site [chemical binding]; other site 813010728 dimer interface [polypeptide binding]; other site 813010729 malate binding site [chemical binding]; other site 813010730 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 813010731 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 813010732 substrate binding pocket [chemical binding]; other site 813010733 membrane-bound complex binding site; other site 813010734 hinge residues; other site 813010735 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 813010736 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 813010737 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 813010738 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 813010739 nucleotide binding site/active site [active] 813010740 Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286 813010741 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 813010742 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 813010743 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 813010744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813010745 homodimer interface [polypeptide binding]; other site 813010746 catalytic residue [active] 813010747 prolyl-tRNA synthetase; Provisional; Region: PRK09194 813010748 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 813010749 dimer interface [polypeptide binding]; other site 813010750 motif 1; other site 813010751 active site 813010752 motif 2; other site 813010753 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 813010754 putative deacylase active site [active] 813010755 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813010756 active site 813010757 motif 3; other site 813010758 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 813010759 anticodon binding site; other site 813010760 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 813010761 GrpE; Region: GrpE; pfam01025 813010762 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 813010763 dimer interface [polypeptide binding]; other site 813010764 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 813010765 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 813010766 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 813010767 nucleotide binding site [chemical binding]; other site 813010768 NEF interaction site [polypeptide binding]; other site 813010769 SBD interface [polypeptide binding]; other site 813010770 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 813010771 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 813010772 Putative zinc ribbon domain; Region: DUF164; pfam02591 813010773 KpsF/GutQ family protein; Region: kpsF; TIGR00393 813010774 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 813010775 putative active site [active] 813010776 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 813010777 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 813010778 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 813010779 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 813010780 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 813010781 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 813010782 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 813010783 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 813010784 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 813010785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813010786 S-adenosylmethionine binding site [chemical binding]; other site 813010787 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 813010788 Lumazine binding domain; Region: Lum_binding; pfam00677 813010789 Lumazine binding domain; Region: Lum_binding; pfam00677 813010790 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 813010791 ATP cone domain; Region: ATP-cone; pfam03477 813010792 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 813010793 poly(A) polymerase; Region: pcnB; TIGR01942 813010794 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 813010795 active site 813010796 NTP binding site [chemical binding]; other site 813010797 metal binding triad [ion binding]; metal-binding site 813010798 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 813010799 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 813010800 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 813010801 Predicted membrane protein [Function unknown]; Region: COG3952 813010802 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 813010803 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813010804 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813010805 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813010806 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813010807 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813010808 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 813010809 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 813010810 intersubunit interface [polypeptide binding]; other site 813010811 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813010812 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 813010813 Walker A/P-loop; other site 813010814 ATP binding site [chemical binding]; other site 813010815 Q-loop/lid; other site 813010816 ABC transporter signature motif; other site 813010817 Walker B; other site 813010818 D-loop; other site 813010819 H-loop/switch region; other site 813010820 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813010821 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813010822 ABC-ATPase subunit interface; other site 813010823 dimer interface [polypeptide binding]; other site 813010824 putative PBP binding regions; other site 813010825 GTPase CgtA; Reviewed; Region: obgE; PRK12299 813010826 GTP1/OBG; Region: GTP1_OBG; pfam01018 813010827 Obg GTPase; Region: Obg; cd01898 813010828 G1 box; other site 813010829 GTP/Mg2+ binding site [chemical binding]; other site 813010830 Switch I region; other site 813010831 G2 box; other site 813010832 G3 box; other site 813010833 Switch II region; other site 813010834 G4 box; other site 813010835 G5 box; other site 813010836 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 813010837 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 813010838 Uncharacterized conserved protein [Function unknown]; Region: COG2928 813010839 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 813010840 FOG: CBS domain [General function prediction only]; Region: COG0517 813010841 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813010842 Transporter associated domain; Region: CorC_HlyC; smart01091 813010843 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 813010844 anti sigma factor interaction site; other site 813010845 regulatory phosphorylation site [posttranslational modification]; other site 813010846 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 813010847 hypothetical protein; Provisional; Region: PRK05926 813010848 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813010849 FeS/SAM binding site; other site 813010850 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 813010851 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 813010852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813010853 S-adenosylmethionine binding site [chemical binding]; other site 813010854 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 813010855 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 813010856 diaminopimelate epimerase; Region: DapF; TIGR00652 813010857 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 813010858 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 813010859 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 813010860 homotrimer interaction site [polypeptide binding]; other site 813010861 zinc binding site [ion binding]; other site 813010862 CDP-binding sites; other site 813010863 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 813010864 elongation factor G; Reviewed; Region: PRK12739 813010865 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 813010866 G1 box; other site 813010867 putative GEF interaction site [polypeptide binding]; other site 813010868 GTP/Mg2+ binding site [chemical binding]; other site 813010869 Switch I region; other site 813010870 G2 box; other site 813010871 G3 box; other site 813010872 Switch II region; other site 813010873 G4 box; other site 813010874 G5 box; other site 813010875 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 813010876 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 813010877 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 813010878 30S ribosomal protein S7; Validated; Region: PRK05302 813010879 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 813010880 S17 interaction site [polypeptide binding]; other site 813010881 S8 interaction site; other site 813010882 16S rRNA interaction site [nucleotide binding]; other site 813010883 streptomycin interaction site [chemical binding]; other site 813010884 23S rRNA interaction site [nucleotide binding]; other site 813010885 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 813010886 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 813010887 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 813010888 protein binding site [polypeptide binding]; other site 813010889 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 813010890 Catalytic dyad [active] 813010891 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 813010892 Domain of unknown function DUF11; Region: DUF11; pfam01345 813010893 Domain of unknown function DUF11; Region: DUF11; pfam01345 813010894 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 813010895 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 813010896 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 813010897 HIGH motif; other site 813010898 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 813010899 active site 813010900 KMSKS motif; other site 813010901 Helix-turn-helix domain; Region: HTH_17; pfam12728 813010902 Helix-turn-helix domain; Region: HTH_17; cl17695 813010903 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 813010904 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 813010905 catalytic residue [active] 813010906 putative FPP diphosphate binding site; other site 813010907 putative FPP binding hydrophobic cleft; other site 813010908 dimer interface [polypeptide binding]; other site 813010909 putative IPP diphosphate binding site; other site 813010910 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 813010911 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 813010912 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 813010913 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 813010914 CMP-binding site; other site 813010915 The sites determining sugar specificity; other site 813010916 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 813010917 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 813010918 hinge; other site 813010919 active site 813010920 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 813010921 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 813010922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 813010923 Coenzyme A binding pocket [chemical binding]; other site 813010924 SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531 813010925 SWI complex, BAF60b domains; Region: SWIB; smart00151 813010926 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 813010927 substrate binding site; other site 813010928 dimer interface; other site 813010929 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 813010930 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 813010931 dimerization interface 3.5A [polypeptide binding]; other site 813010932 active site 813010933 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 813010934 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 813010935 active site 813010936 motif I; other site 813010937 motif II; other site 813010938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 813010939 Response regulator receiver domain; Region: Response_reg; pfam00072 813010940 active site 813010941 phosphorylation site [posttranslational modification] 813010942 intermolecular recognition site; other site 813010943 dimerization interface [polypeptide binding]; other site 813010944 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813010945 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 813010946 Walker A motif; other site 813010947 ATP binding site [chemical binding]; other site 813010948 Walker B motif; other site 813010949 arginine finger; other site 813010950 Uncharacterized conserved protein [Function unknown]; Region: COG1723 813010951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813010952 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 813010953 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 813010954 DNA binding site [nucleotide binding] 813010955 active site 813010956 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 813010957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813010958 dimer interface [polypeptide binding]; other site 813010959 conserved gate region; other site 813010960 putative PBP binding loops; other site 813010961 ABC-ATPase subunit interface; other site 813010962 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 813010963 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813010964 transcription termination factor Rho; Region: rho; TIGR00767 813010965 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 813010966 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 813010967 RNA binding site [nucleotide binding]; other site 813010968 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 813010969 multimer interface [polypeptide binding]; other site 813010970 Walker A motif; other site 813010971 ATP binding site [chemical binding]; other site 813010972 Walker B motif; other site 813010973 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 813010974 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 813010975 CoA-binding site [chemical binding]; other site 813010976 ATP-binding [chemical binding]; other site 813010977 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 813010978 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 813010979 tandem repeat interface [polypeptide binding]; other site 813010980 oligomer interface [polypeptide binding]; other site 813010981 active site residues [active] 813010982 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 813010983 replicative DNA helicase; Provisional; Region: PRK06321 813010984 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 813010985 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 813010986 Walker A motif; other site 813010987 ATP binding site [chemical binding]; other site 813010988 Walker B motif; other site 813010989 DNA binding loops [nucleotide binding] 813010990 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 813010991 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 813010992 RuvA N terminal domain; Region: RuvA_N; pfam01330 813010993 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 813010994 active site 813010995 putative DNA-binding cleft [nucleotide binding]; other site 813010996 dimer interface [polypeptide binding]; other site 813010997 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 813010998 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 813010999 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 813011000 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 813011001 alphaNTD - beta interaction site [polypeptide binding]; other site 813011002 alphaNTD homodimer interface [polypeptide binding]; other site 813011003 alphaNTD - beta' interaction site [polypeptide binding]; other site 813011004 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 813011005 30S ribosomal protein S11; Validated; Region: PRK05309 813011006 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 813011007 30S ribosomal protein S13; Region: bact_S13; TIGR03631 813011008 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 813011009 SecY translocase; Region: SecY; pfam00344 813011010 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 813011011 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 813011012 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 813011013 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 813011014 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 813011015 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 813011016 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 813011017 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 813011018 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 813011019 RNA binding site [nucleotide binding]; other site 813011020 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 813011021 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 813011022 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 813011023 23S rRNA interface [nucleotide binding]; other site 813011024 putative translocon interaction site; other site 813011025 signal recognition particle (SRP54) interaction site; other site 813011026 L23 interface [polypeptide binding]; other site 813011027 trigger factor interaction site; other site 813011028 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 813011029 23S rRNA interface [nucleotide binding]; other site 813011030 5S rRNA interface [nucleotide binding]; other site 813011031 putative antibiotic binding site [chemical binding]; other site 813011032 L25 interface [polypeptide binding]; other site 813011033 L27 interface [polypeptide binding]; other site 813011034 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 813011035 putative translocon binding site; other site 813011036 protein-rRNA interface [nucleotide binding]; other site 813011037 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 813011038 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 813011039 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 813011040 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 813011041 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 813011042 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 813011043 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 813011044 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 813011045 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 813011046 putative active site [active] 813011047 substrate binding site [chemical binding]; other site 813011048 putative cosubstrate binding site; other site 813011049 catalytic site [active] 813011050 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 813011051 substrate binding site [chemical binding]; other site 813011052 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 813011053 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 813011054 active site 813011055 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 813011056 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 813011057 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 813011058 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 813011059 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 813011060 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 813011061 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813011062 catalytic residues [active] 813011063 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 813011064 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 813011065 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 813011066 active site 813011067 PHP Thumb interface [polypeptide binding]; other site 813011068 metal binding site [ion binding]; metal-binding site 813011069 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 813011070 generic binding surface I; other site 813011071 generic binding surface II; other site 813011072 TPR repeat; Region: TPR_11; pfam13414 813011073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813011074 binding surface 813011075 TPR motif; other site 813011076 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 813011077 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 813011078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 813011079 Mg2+ binding site [ion binding]; other site 813011080 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 813011081 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 813011082 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 813011083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813011084 S-adenosylmethionine binding site [chemical binding]; other site 813011085 branched-chain amino acid uptake carrier; Region: livcs; TIGR00796 813011086 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 813011087 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813011088 ATP binding site [chemical binding]; other site 813011089 putative Mg++ binding site [ion binding]; other site 813011090 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813011091 ATP-binding site [chemical binding]; other site 813011092 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 813011093 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 813011094 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 813011095 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 813011096 lipoate synthase; Region: lipA; TIGR00510 813011097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813011098 FeS/SAM binding site; other site 813011099 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 813011100 type III secretion system protein; Validated; Region: PRK06328 813011101 Flagellar assembly protein FliH; Region: FliH; pfam02108 813011102 type III secretion system protein; Reviewed; Region: PRK09617 813011103 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 813011104 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 813011105 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 813011106 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 813011107 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 813011108 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 813011109 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 813011110 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 813011111 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 813011112 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 813011113 Walker A motif; other site 813011114 ATP binding site [chemical binding]; other site 813011115 Walker B motif; other site 813011116 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 813011117 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 813011118 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 813011119 active site 813011120 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 813011121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813011122 ATP binding site [chemical binding]; other site 813011123 Mg2+ binding site [ion binding]; other site 813011124 G-X-G motif; other site 813011125 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 813011126 ATP binding site [chemical binding]; other site 813011127 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 813011128 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 813011129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813011130 binding surface 813011131 TPR motif; other site 813011132 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 813011133 EamA-like transporter family; Region: EamA; pfam00892 813011134 EamA-like transporter family; Region: EamA; pfam00892 813011135 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 813011136 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 813011137 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 813011138 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 813011139 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 813011140 active site 813011141 HIGH motif; other site 813011142 dimer interface [polypeptide binding]; other site 813011143 KMSKS motif; other site 813011144 excinuclease ABC subunit B; Provisional; Region: PRK05298 813011145 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813011146 ATP binding site [chemical binding]; other site 813011147 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813011148 nucleotide binding region [chemical binding]; other site 813011149 ATP-binding site [chemical binding]; other site 813011150 Ultra-violet resistance protein B; Region: UvrB; pfam12344 813011151 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 813011152 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 813011153 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 813011154 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 813011155 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 813011156 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 813011157 active site 813011158 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 813011159 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 813011160 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 813011161 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 813011162 DsbD alpha interface [polypeptide binding]; other site 813011163 catalytic residues [active] 813011164 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 813011165 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 813011166 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 813011167 translocation protein TolB; Provisional; Region: tolB; PRK01029 813011168 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813011169 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813011170 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813011171 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 813011172 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 813011173 ligand binding site [chemical binding]; other site 813011174 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 813011175 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813011176 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 813011177 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 813011178 dimer interface [polypeptide binding]; other site 813011179 decamer (pentamer of dimers) interface [polypeptide binding]; other site 813011180 catalytic triad [active] 813011181 peroxidatic and resolving cysteines [active] 813011182 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 813011183 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 813011184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 813011185 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 813011186 ligand binding site [chemical binding]; other site 813011187 active site 813011188 UGI interface [polypeptide binding]; other site 813011189 catalytic site [active] 813011190 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 813011191 Part of AAA domain; Region: AAA_19; pfam13245 813011192 Family description; Region: UvrD_C_2; pfam13538 813011193 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 813011194 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 813011195 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 813011196 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 813011197 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 813011198 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 813011199 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 813011200 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 813011201 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 813011202 folate binding site [chemical binding]; other site 813011203 NADP+ binding site [chemical binding]; other site 813011204 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 813011205 catalytic center binding site [active] 813011206 ATP binding site [chemical binding]; other site 813011207 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 813011208 dihydropteroate synthase; Region: DHPS; TIGR01496 813011209 substrate binding pocket [chemical binding]; other site 813011210 dimer interface [polypeptide binding]; other site 813011211 inhibitor binding site; inhibition site 813011212 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 813011213 homooctamer interface [polypeptide binding]; other site 813011214 active site 813011215 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 813011216 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 813011217 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 813011218 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 813011219 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 813011220 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 813011221 DNA binding residues [nucleotide binding] 813011222 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 813011223 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 813011224 Effector from type III secretion system; Region: Effector_1; pfam04518 813011225 Effector from type III secretion system; Region: Effector_1; pfam04518 813011226 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 813011227 MviN-like protein; Region: MVIN; pfam03023 813011228 endonuclease IV; Provisional; Region: PRK01060 813011229 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 813011230 AP (apurinic/apyrimidinic) site pocket; other site 813011231 DNA interaction; other site 813011232 Metal-binding active site; metal-binding site 813011233 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 813011234 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 813011235 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813011236 RNA binding surface [nucleotide binding]; other site 813011237 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 813011238 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 813011239 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 813011240 FMN binding site [chemical binding]; other site 813011241 active site 813011242 catalytic residues [active] 813011243 substrate binding site [chemical binding]; other site 813011244 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 813011245 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 813011246 recombinase A; Provisional; Region: recA; PRK09354 813011247 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 813011248 hexamer interface [polypeptide binding]; other site 813011249 Walker A motif; other site 813011250 ATP binding site [chemical binding]; other site 813011251 Walker B motif; other site 813011252 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 813011253 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 813011254 AAA domain; Region: AAA_30; pfam13604 813011255 Family description; Region: UvrD_C_2; pfam13538 813011256 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 813011257 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 813011258 Walker A/P-loop; other site 813011259 ATP binding site [chemical binding]; other site 813011260 Q-loop/lid; other site 813011261 ABC transporter signature motif; other site 813011262 Walker B; other site 813011263 D-loop; other site 813011264 H-loop/switch region; other site 813011265 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 813011266 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 813011267 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 813011268 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 813011269 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813011270 RNA binding surface [nucleotide binding]; other site 813011271 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 813011272 active site 813011273 hypothetical protein; Provisional; Region: PRK01064 813011274 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 813011275 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 813011276 DNA Topoisomerase IV; Region: TOP4c; smart00434 813011277 CAP-like domain; other site 813011278 active site 813011279 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 813011280 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 813011281 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813011282 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 813011283 phosphopeptide binding site; other site 813011284 MARCKS family; Region: MARCKS; pfam02063 813011285 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 813011286 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 813011287 phosphopeptide binding site; other site 813011288 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 813011289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 813011290 binding surface 813011291 Tetratricopeptide repeat; Region: TPR_16; pfam13432 813011292 TPR motif; other site 813011293 type III secretion system protein; Validated; Region: PRK05933 813011294 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 813011295 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 813011296 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813011297 active site 813011298 ATP binding site [chemical binding]; other site 813011299 substrate binding site [chemical binding]; other site 813011300 activation loop (A-loop); other site 813011301 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 813011302 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813011303 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813011304 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 813011305 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 813011306 putative nucleotide binding site [chemical binding]; other site 813011307 uridine monophosphate binding site [chemical binding]; other site 813011308 homohexameric interface [polypeptide binding]; other site 813011309 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 813011310 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 813011311 Elongation factor TS; Region: EF_TS; pfam00889 813011312 Elongation factor TS; Region: EF_TS; pfam00889 813011313 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 813011314 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813011315 Walker A/P-loop; other site 813011316 ATP binding site [chemical binding]; other site 813011317 Q-loop/lid; other site 813011318 ABC transporter signature motif; other site 813011319 Walker B; other site 813011320 D-loop; other site 813011321 H-loop/switch region; other site 813011322 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813011323 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 813011324 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 813011325 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 813011326 Phosphoglycerate kinase; Region: PGK; pfam00162 813011327 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 813011328 substrate binding site [chemical binding]; other site 813011329 hinge regions; other site 813011330 ADP binding site [chemical binding]; other site 813011331 catalytic site [active] 813011332 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 813011333 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 813011334 minor groove reading motif; other site 813011335 helix-hairpin-helix signature motif; other site 813011336 substrate binding pocket [chemical binding]; other site 813011337 active site 813011338 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 813011339 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 813011340 trmE is a tRNA modification GTPase; Region: trmE; cd04164 813011341 G1 box; other site 813011342 GTP/Mg2+ binding site [chemical binding]; other site 813011343 Switch I region; other site 813011344 G2 box; other site 813011345 Switch II region; other site 813011346 G3 box; other site 813011347 G4 box; other site 813011348 G5 box; other site 813011349 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 813011350 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 813011351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813011352 binding surface 813011353 TPR motif; other site 813011354 Predicted GTPases [General function prediction only]; Region: COG1160 813011355 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 813011356 G1 box; other site 813011357 GTP/Mg2+ binding site [chemical binding]; other site 813011358 Switch I region; other site 813011359 G2 box; other site 813011360 Switch II region; other site 813011361 G3 box; other site 813011362 G4 box; other site 813011363 G5 box; other site 813011364 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 813011365 G1 box; other site 813011366 GTP/Mg2+ binding site [chemical binding]; other site 813011367 Switch I region; other site 813011368 G2 box; other site 813011369 G3 box; other site 813011370 Switch II region; other site 813011371 G4 box; other site 813011372 G5 box; other site 813011373 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 813011374 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 813011375 active site 813011376 NTP binding site [chemical binding]; other site 813011377 metal binding triad [ion binding]; metal-binding site 813011378 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 813011379 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 813011380 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 813011381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813011382 Walker A motif; other site 813011383 ATP binding site [chemical binding]; other site 813011384 Walker B motif; other site 813011385 arginine finger; other site 813011386 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 813011387 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 813011388 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 813011389 oligomer interface [polypeptide binding]; other site 813011390 active site residues [active] 813011391 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 813011392 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 813011393 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 813011394 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 813011395 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813011396 ATP binding site [chemical binding]; other site 813011397 putative Mg++ binding site [ion binding]; other site 813011398 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813011399 nucleotide binding region [chemical binding]; other site 813011400 ATP-binding site [chemical binding]; other site 813011401 rod shape-determining protein MreB; Provisional; Region: PRK13927 813011402 MreB and similar proteins; Region: MreB_like; cd10225 813011403 nucleotide binding site [chemical binding]; other site 813011404 Mg binding site [ion binding]; other site 813011405 putative protofilament interaction site [polypeptide binding]; other site 813011406 RodZ interaction site [polypeptide binding]; other site 813011407 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 813011408 active site 813011409 substrate-binding site [chemical binding]; other site 813011410 metal-binding site [ion binding] 813011411 GTP binding site [chemical binding]; other site 813011412 Effector from type III secretion system; Region: Effector_1; pfam04518 813011413 Effector from type III secretion system; Region: Effector_1; pfam04518 813011414 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 813011415 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 813011416 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 813011417 active site 813011418 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 813011419 type III secretion system ATPase; Validated; Region: PRK05922 813011420 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813011421 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 813011422 Walker A motif; other site 813011423 ATP binding site [chemical binding]; other site 813011424 Walker B motif; other site 813011425 type III secretion system protein; Validated; Region: PRK05934 813011426 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 813011427 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 813011428 active site 813011429 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 813011430 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 813011431 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813011432 catalytic residue [active] 813011433 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 813011434 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813011435 RNA binding surface [nucleotide binding]; other site 813011436 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 813011437 active site 813011438 biotin--protein ligase; Provisional; Region: PRK05935 813011439 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 813011440 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 813011441 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 813011442 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 813011443 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 813011444 motif II; other site 813011445 CCC1-related protein family; Region: CCC1_like_1; cd02437 813011446 seryl-tRNA synthetase; Provisional; Region: PRK05431 813011447 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 813011448 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 813011449 dimer interface [polypeptide binding]; other site 813011450 active site 813011451 motif 1; other site 813011452 motif 2; other site 813011453 motif 3; other site 813011454 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 813011455 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 813011456 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 813011457 dimerization interface [polypeptide binding]; other site 813011458 active site 813011459 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 813011460 homopentamer interface [polypeptide binding]; other site 813011461 active site 813011462 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 813011463 substrate binding site [chemical binding]; other site 813011464 Proteins containing SET domain [General function prediction only]; Region: COG2940 813011465 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 813011466 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 813011467 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 813011468 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 813011469 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 813011470 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 813011471 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 813011472 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 813011473 catalytic loop [active] 813011474 iron binding site [ion binding]; other site 813011475 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 813011476 FAD binding pocket [chemical binding]; other site 813011477 FAD binding motif [chemical binding]; other site 813011478 phosphate binding motif [ion binding]; other site 813011479 beta-alpha-beta structure motif; other site 813011480 NAD binding pocket [chemical binding]; other site 813011481 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 813011482 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 813011483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813011484 S-adenosylmethionine binding site [chemical binding]; other site 813011485 Histone H1-like protein Hc1; Region: Hc1; pfam07432 813011486 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813011487 binding surface 813011488 TPR motif; other site 813011489 Tetratricopeptide repeat; Region: TPR_12; pfam13424 813011490 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 813011491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 813011492 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 813011493 HemN C-terminal domain; Region: HemN_C; pfam06969 813011494 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 813011495 substrate binding site [chemical binding]; other site 813011496 active site 813011497 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 813011498 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 813011499 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813011500 ATP binding site [chemical binding]; other site 813011501 putative Mg++ binding site [ion binding]; other site 813011502 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813011503 nucleotide binding region [chemical binding]; other site 813011504 ATP-binding site [chemical binding]; other site 813011505 TRCF domain; Region: TRCF; pfam03461 813011506 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 813011507 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 813011508 motif 1; other site 813011509 active site 813011510 motif 2; other site 813011511 motif 3; other site 813011512 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 813011513 DHHA1 domain; Region: DHHA1; pfam02272 813011514 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 813011515 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 813011516 TPP-binding site [chemical binding]; other site 813011517 dimer interface [polypeptide binding]; other site 813011518 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 813011519 PYR/PP interface [polypeptide binding]; other site 813011520 dimer interface [polypeptide binding]; other site 813011521 TPP binding site [chemical binding]; other site 813011522 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813011523 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 813011524 elongation factor P; Validated; Region: PRK00529 813011525 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 813011526 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 813011527 RNA binding site [nucleotide binding]; other site 813011528 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 813011529 RNA binding site [nucleotide binding]; other site 813011530 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813011531 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 813011532 putative active site [active] 813011533 putative metal binding site [ion binding]; other site 813011534 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 813011535 active site 813011536 metal binding site [ion binding]; metal-binding site 813011537 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 813011538 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 813011539 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 813011540 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813011541 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813011542 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 813011543 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 813011544 Mg++ binding site [ion binding]; other site 813011545 putative catalytic motif [active] 813011546 putative substrate binding site [chemical binding]; other site 813011547 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 813011548 TrkA-N domain; Region: TrkA_N; pfam02254 813011549 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813011550 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813011551 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 813011552 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813011553 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813011554 cell division protein FtsW; Region: ftsW; TIGR02614 813011555 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 813011556 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 813011557 active site 813011558 homodimer interface [polypeptide binding]; other site 813011559 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 813011560 anti sigma factor interaction site; other site 813011561 regulatory phosphorylation site [posttranslational modification]; other site 813011562 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813011563 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 813011564 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 813011565 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 813011566 dimer interface [polypeptide binding]; other site 813011567 active site 813011568 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 813011569 active site 813011570 Ap4A binding cleft/pocket [chemical binding]; other site 813011571 P4 phosphate binding site; other site 813011572 nudix motif; other site 813011573 putative P2/P3 phosphate binding site [ion binding]; other site 813011574 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 813011575 dimer interface [polypeptide binding]; other site 813011576 substrate binding site [chemical binding]; other site 813011577 metal binding sites [ion binding]; metal-binding site 813011578 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 813011579 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 813011580 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 813011581 NAD binding site [chemical binding]; other site 813011582 Phe binding site; other site 813011583 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 813011584 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 813011585 active site 813011586 putative lithium-binding site [ion binding]; other site 813011587 substrate binding site [chemical binding]; other site 813011588 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 813011589 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 813011590 putative acyl-acceptor binding pocket; other site 813011591 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 813011592 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 813011593 acyl-activating enzyme (AAE) consensus motif; other site 813011594 AMP binding site [chemical binding]; other site 813011595 active site 813011596 CoA binding site [chemical binding]; other site 813011597 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 813011598 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813011599 ATP binding site [chemical binding]; other site 813011600 putative Mg++ binding site [ion binding]; other site 813011601 helicase superfamily c-terminal domain; Region: HELICc; smart00490 813011602 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 813011603 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813011604 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 813011605 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 813011606 dimer interface [polypeptide binding]; other site 813011607 putative anticodon binding site; other site 813011608 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813011609 motif 1; other site 813011610 dimer interface [polypeptide binding]; other site 813011611 active site 813011612 motif 2; other site 813011613 motif 3; other site 813011614 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 813011615 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 813011616 active site 813011617 HIGH motif; other site 813011618 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 813011619 KMSKS motif; other site 813011620 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813011621 tRNA binding surface [nucleotide binding]; other site 813011622 anticodon binding site; other site 813011623 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 813011624 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813011625 ribonuclease P; Reviewed; Region: rnpA; PRK00730 813011626 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 813011627 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 813011628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 813011629 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 813011630 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 813011631 GIY-YIG motif/motif A; other site 813011632 active site 813011633 catalytic site [active] 813011634 putative DNA binding site [nucleotide binding]; other site 813011635 metal binding site [ion binding]; metal-binding site 813011636 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 813011637 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 813011638 MutS domain I; Region: MutS_I; pfam01624 813011639 MutS domain II; Region: MutS_II; pfam05188 813011640 MutS domain III; Region: MutS_III; pfam05192 813011641 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 813011642 Walker A/P-loop; other site 813011643 ATP binding site [chemical binding]; other site 813011644 Q-loop/lid; other site 813011645 ABC transporter signature motif; other site 813011646 Walker B; other site 813011647 D-loop; other site 813011648 H-loop/switch region; other site 813011649 DNA primase; Validated; Region: dnaG; PRK05667 813011650 CHC2 zinc finger; Region: zf-CHC2; pfam01807 813011651 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 813011652 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 813011653 active site 813011654 metal binding site [ion binding]; metal-binding site 813011655 interdomain interaction site; other site 813011656 glycyl-tRNA synthetase; Provisional; Region: PRK14908 813011657 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 813011658 dimer interface [polypeptide binding]; other site 813011659 motif 1; other site 813011660 active site 813011661 motif 2; other site 813011662 motif 3; other site 813011663 DALR anticodon binding domain; Region: DALR_1; pfam05746 813011664 glycogen synthase; Provisional; Region: glgA; PRK00654 813011665 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 813011666 ADP-binding pocket [chemical binding]; other site 813011667 homodimer interface [polypeptide binding]; other site 813011668 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 813011669 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 813011670 5S rRNA interface [nucleotide binding]; other site 813011671 CTC domain interface [polypeptide binding]; other site 813011672 L16 interface [polypeptide binding]; other site 813011673 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 813011674 putative active site [active] 813011675 catalytic residue [active] 813011676 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 813011677 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 813011678 Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359 813011679 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 813011680 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 813011681 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 813011682 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 813011683 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 813011684 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813011685 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813011686 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 813011687 putative acyl-acceptor binding pocket; other site 813011688 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 813011689 YtxH-like protein; Region: YtxH; cl02079 813011690 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 813011691 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 813011692 glutaminase active site [active] 813011693 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 813011694 dimer interface [polypeptide binding]; other site 813011695 active site 813011696 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 813011697 dimer interface [polypeptide binding]; other site 813011698 active site 813011699 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 813011700 aromatic amino acid transport protein; Region: araaP; TIGR00837 813011701 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 813011702 aromatic amino acid transport protein; Region: araaP; TIGR00837 813011703 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 813011704 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 813011705 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 813011706 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 813011707 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 813011708 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 813011709 CoA-ligase; Region: Ligase_CoA; pfam00549 813011710 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 813011711 CoA binding domain; Region: CoA_binding; smart00881 813011712 CoA-ligase; Region: Ligase_CoA; pfam00549 813011713 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 813011714 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 813011715 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 813011716 protein binding site [polypeptide binding]; other site 813011717 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 813011718 protein binding site [polypeptide binding]; other site 813011719 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 813011720 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 813011721 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813011722 Peptidase M16C associated; Region: M16C_assoc; pfam08367 813011723 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813011724 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 813011725 RmuC family; Region: RmuC; pfam02646 813011726 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 813011727 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 813011728 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 813011729 ATP cone domain; Region: ATP-cone; pfam03477 813011730 ATP cone domain; Region: ATP-cone; pfam03477 813011731 Class I ribonucleotide reductase; Region: RNR_I; cd01679 813011732 active site 813011733 dimer interface [polypeptide binding]; other site 813011734 catalytic residues [active] 813011735 effector binding site; other site 813011736 R2 peptide binding site; other site 813011737 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 813011738 dimer interface [polypeptide binding]; other site 813011739 putative radical transfer pathway; other site 813011740 diiron center [ion binding]; other site 813011741 tyrosyl radical; other site 813011742 Putative methyltransferase; Region: Methyltransf_4; pfam02390 813011743 Methyltransferase domain; Region: Methyltransf_18; pfam12847 813011744 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 813011745 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 813011746 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 813011747 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 813011748 Ribosomal protein L35 [Translation, ribosomal structure and biogenesis]; Region: RpmI; COG0291 813011749 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 813011750 23S rRNA binding site [nucleotide binding]; other site 813011751 L21 binding site [polypeptide binding]; other site 813011752 L13 binding site [polypeptide binding]; other site 813011753 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 813011754 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 813011755 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 813011756 motif 1; other site 813011757 dimer interface [polypeptide binding]; other site 813011758 active site 813011759 motif 2; other site 813011760 motif 3; other site 813011761 Predicted permeases [General function prediction only]; Region: COG0795 813011762 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 813011763 Predicted permeases [General function prediction only]; Region: COG0795 813011764 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 813011765 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 813011766 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 813011767 Ligand Binding Site [chemical binding]; other site 813011768 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 813011769 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 813011770 RNase E interface [polypeptide binding]; other site 813011771 trimer interface [polypeptide binding]; other site 813011772 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 813011773 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 813011774 RNase E interface [polypeptide binding]; other site 813011775 trimer interface [polypeptide binding]; other site 813011776 active site 813011777 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 813011778 putative nucleic acid binding region [nucleotide binding]; other site 813011779 G-X-X-G motif; other site 813011780 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 813011781 RNA binding site [nucleotide binding]; other site 813011782 domain interface; other site 813011783 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 813011784 16S/18S rRNA binding site [nucleotide binding]; other site 813011785 S13e-L30e interaction site [polypeptide binding]; other site 813011786 25S rRNA binding site [nucleotide binding]; other site 813011787 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813011788 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813011789 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813011790 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813011791 MarC family integral membrane protein; Region: MarC; pfam01914 813011792 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 813011793 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 813011794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813011795 dimer interface [polypeptide binding]; other site 813011796 conserved gate region; other site 813011797 putative PBP binding loops; other site 813011798 ABC-ATPase subunit interface; other site 813011799 NMT1/THI5 like; Region: NMT1; pfam09084 813011800 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 813011801 tetramer interface [polypeptide binding]; other site 813011802 high affinity sulphate transporter 1; Region: sulP; TIGR00815 813011803 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 813011804 Sulfate transporter family; Region: Sulfate_transp; pfam00916 813011805 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 813011806 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 813011807 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 813011808 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 813011809 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 813011810 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 813011811 active site triad [active] 813011812 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 813011813 LytB protein; Region: LYTB; pfam02401 813011814 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 813011815 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 813011816 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 813011817 binding surface 813011818 TPR motif; other site 813011819 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 813011820 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 813011821 active site 813011822 DNA binding site [nucleotide binding] 813011823 Int/Topo IB signature motif; other site 813011824 glycogen branching enzyme; Provisional; Region: PRK05402 813011825 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 813011826 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 813011827 active site 813011828 catalytic site [active] 813011829 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 813011830 Uncharacterized conserved protein [Function unknown]; Region: COG2155 813011831 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 813011832 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 813011833 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 813011834 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 813011835 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 813011836 GatB domain; Region: GatB_Yqey; pfam02637 813011837 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 813011838 ribonuclease HIII; Region: rnhC; TIGR00716 813011839 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 813011840 RNA/DNA hybrid binding site [nucleotide binding]; other site 813011841 active site 813011842 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 813011843 Helix-turn-helix domain; Region: HTH_25; pfam13413 813011844 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906 813011845 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 813011846 putative acyl-acceptor binding pocket; other site 813011847 Uncharacterized conserved protein [Function unknown]; Region: COG1624 813011848 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 813011849 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 813011850 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 813011851 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 813011852 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 813011853 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 813011854 HIGH motif; other site 813011855 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 813011856 active site 813011857 KMSKS motif; other site 813011858 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 813011859 tRNA binding surface [nucleotide binding]; other site 813011860 anticodon binding site; other site 813011861 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 813011862 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 813011863 Catalytic site [active] 813011864 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 813011865 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 813011866 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 813011867 peptide chain release factor 1; Validated; Region: prfA; PRK00591 813011868 PCRF domain; Region: PCRF; pfam03462 813011869 RF-1 domain; Region: RF-1; pfam00472 813011870 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 813011871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813011872 S-adenosylmethionine binding site [chemical binding]; other site 813011873 signal recognition particle protein; Provisional; Region: PRK10867 813011874 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 813011875 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 813011876 P loop; other site 813011877 GTP binding site [chemical binding]; other site 813011878 Signal peptide binding domain; Region: SRP_SPB; pfam02978 813011879 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 813011880 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 813011881 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 813011882 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 813011883 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 813011884 RNA/DNA hybrid binding site [nucleotide binding]; other site 813011885 active site 813011886 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 813011887 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 813011888 catalytic site [active] 813011889 G-X2-G-X-G-K; other site 813011890 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 813011891 AAA domain; Region: AAA_30; pfam13604 813011892 Family description; Region: UvrD_C_2; pfam13538 813011893 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 813011894 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 813011895 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 813011896 conserved cys residue [active] 813011897 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 813011898 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 813011899 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 813011900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813011901 Walker A motif; other site 813011902 ATP binding site [chemical binding]; other site 813011903 Walker B motif; other site 813011904 arginine finger; other site 813011905 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 813011906 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813011907 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 813011908 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 813011909 dimer interface [polypeptide binding]; other site 813011910 ssDNA binding site [nucleotide binding]; other site 813011911 tetramer (dimer of dimers) interface [polypeptide binding]; other site 813011912 multifunctional aminopeptidase A; Provisional; Region: PRK00913 813011913 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 813011914 interface (dimer of trimers) [polypeptide binding]; other site 813011915 Substrate-binding/catalytic site; other site 813011916 Zn-binding sites [ion binding]; other site 813011917 hypothetical protein; Provisional; Region: PRK05907 813011918 Predicted methyltransferases [General function prediction only]; Region: COG0313 813011919 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 813011920 putative SAM binding site [chemical binding]; other site 813011921 homodimer interface [polypeptide binding]; other site 813011922 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 813011923 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813011924 FeS/SAM binding site; other site 813011925 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 813011926 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 813011927 TPP-binding site [chemical binding]; other site 813011928 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 813011929 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 813011930 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813011931 E3 interaction surface; other site 813011932 lipoyl attachment site [posttranslational modification]; other site 813011933 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813011934 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 813011935 1-hydroxy-2-methyl-2-(e)-butenyl 4-diphosphate synthase [Lipid metabolism]; Region: gcpE; COG0821 813011936 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 813011937 ADP-ribose binding site [chemical binding]; other site 813011938 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 813011939 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 813011940 catalytic loop [active] 813011941 iron binding site [ion binding]; other site 813011942 type III secretion system protein; Validated; Region: PRK05910 813011943 FHIPEP family; Region: FHIPEP; pfam00771 813011944 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 813011945 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 813011946 active site 813011947 HIGH motif; other site 813011948 dimer interface [polypeptide binding]; other site 813011949 KMSKS motif; other site 813011950 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813011951 RNA binding surface [nucleotide binding]; other site 813011952 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 813011953 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 813011954 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 813011955 GTP-binding protein LepA; Provisional; Region: PRK05433 813011956 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 813011957 G1 box; other site 813011958 putative GEF interaction site [polypeptide binding]; other site 813011959 GTP/Mg2+ binding site [chemical binding]; other site 813011960 Switch I region; other site 813011961 G2 box; other site 813011962 G3 box; other site 813011963 Switch II region; other site 813011964 G4 box; other site 813011965 G5 box; other site 813011966 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 813011967 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 813011968 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 813011969 ADP/ATP carrier protein family; Region: AAA; TIGR00769 813011970 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 813011971 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 813011972 intersubunit interface [polypeptide binding]; other site 813011973 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 813011974 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 813011975 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813011976 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813011977 ABC-ATPase subunit interface; other site 813011978 dimer interface [polypeptide binding]; other site 813011979 putative PBP binding regions; other site 813011980 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 813011981 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 813011982 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813011983 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813011984 ABC-ATPase subunit interface; other site 813011985 dimer interface [polypeptide binding]; other site 813011986 putative PBP binding regions; other site 813011987 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 813011988 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 813011989 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 813011990 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 813011991 RIP metalloprotease RseP; Region: TIGR00054 813011992 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 813011993 active site 813011994 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 813011995 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 813011996 putative substrate binding region [chemical binding]; other site 813011997 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 813011998 Putative serine esterase (DUF676); Region: DUF676; pfam05057 813011999 recF protein; Region: recf; TIGR00611 813012000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813012001 Walker A/P-loop; other site 813012002 ATP binding site [chemical binding]; other site 813012003 Q-loop/lid; other site 813012004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813012005 ABC transporter signature motif; other site 813012006 Walker B; other site 813012007 DNA polymerase III subunit beta; Validated; Region: PRK05643 813012008 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 813012009 putative DNA binding surface [nucleotide binding]; other site 813012010 dimer interface [polypeptide binding]; other site 813012011 beta-clamp/clamp loader binding surface; other site 813012012 beta-clamp/translesion DNA polymerase binding surface; other site 813012013 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 813012014 SmpB-tmRNA interface; other site 813012015 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 813012016 ApbE family; Region: ApbE; pfam02424 813012017 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 813012018 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 813012019 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 813012020 homodimer interface [polypeptide binding]; other site 813012021 NADP binding site [chemical binding]; other site 813012022 substrate binding site [chemical binding]; other site 813012023 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813012024 PLD-like domain; Region: PLDc_2; pfam13091 813012025 putative active site [active] 813012026 catalytic site [active] 813012027 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813012028 PLD-like domain; Region: PLDc_2; pfam13091 813012029 putative active site [active] 813012030 catalytic site [active] 813012031 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 813012032 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813012033 HrpJ-like domain; Region: HrpJ; cl15454 813012034 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 813012035 FHIPEP family; Region: FHIPEP; pfam00771 813012036 type III secretion system protein; Validated; Region: PRK06298 813012037 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 813012038 GTP-binding protein YchF; Reviewed; Region: PRK09601 813012039 YchF GTPase; Region: YchF; cd01900 813012040 G1 box; other site 813012041 GTP/Mg2+ binding site [chemical binding]; other site 813012042 Switch I region; other site 813012043 G2 box; other site 813012044 Switch II region; other site 813012045 G3 box; other site 813012046 G4 box; other site 813012047 G5 box; other site 813012048 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 813012049 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 813012050 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 813012051 active site 813012052 Riboflavin kinase; Region: Flavokinase; smart00904 813012053 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 813012054 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 813012055 RNA binding site [nucleotide binding]; other site 813012056 active site 813012057 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 813012058 transcription termination factor NusA; Region: NusA; TIGR01953 813012059 NusA N-terminal domain; Region: NusA_N; pfam08529 813012060 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 813012061 RNA binding site [nucleotide binding]; other site 813012062 homodimer interface [polypeptide binding]; other site 813012063 NusA-like KH domain; Region: KH_5; pfam13184 813012064 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 813012065 G-X-X-G motif; other site 813012066 ribosomal protein S1; Region: rpsA; TIGR00717 813012067 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 813012068 RNA binding site [nucleotide binding]; other site 813012069 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 813012070 RNA binding site [nucleotide binding]; other site 813012071 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813012072 RNA binding site [nucleotide binding]; other site 813012073 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813012074 RNA binding site [nucleotide binding]; other site 813012075 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 813012076 RNA binding site [nucleotide binding]; other site 813012077 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 813012078 RNA binding site [nucleotide binding]; other site 813012079 domain interface; other site 813012080 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 813012081 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 813012082 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 813012083 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 813012084 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 813012085 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 813012086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 813012087 active site 813012088 motif I; other site 813012089 motif II; other site 813012090 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 813012091 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 813012092 NAD binding site [chemical binding]; other site 813012093 homotetramer interface [polypeptide binding]; other site 813012094 homodimer interface [polypeptide binding]; other site 813012095 substrate binding site [chemical binding]; other site 813012096 active site 813012097 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 813012098 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813012099 RNA binding surface [nucleotide binding]; other site 813012100 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 813012101 active site 813012102 Uncharacterized conserved protein [Function unknown]; Region: COG0327 813012103 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 813012104 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 813012105 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 813012106 ring oligomerisation interface [polypeptide binding]; other site 813012107 ATP/Mg binding site [chemical binding]; other site 813012108 stacking interactions; other site 813012109 hinge regions; other site 813012110 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 813012111 oligomerisation interface [polypeptide binding]; other site 813012112 mobile loop; other site 813012113 roof hairpin; other site 813012114 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 813012115 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 813012116 active site 813012117 Zn binding site [ion binding]; other site 813012118 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 813012119 Clp amino terminal domain; Region: Clp_N; pfam02861 813012120 Clp amino terminal domain; Region: Clp_N; pfam02861 813012121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813012122 Walker A motif; other site 813012123 ATP binding site [chemical binding]; other site 813012124 Walker B motif; other site 813012125 arginine finger; other site 813012126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813012127 Walker A motif; other site 813012128 ATP binding site [chemical binding]; other site 813012129 Walker B motif; other site 813012130 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 813012131 Uncharacterized conserved protein [Function unknown]; Region: COG2912 813012132 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 813012133 IncA protein; Region: IncA; pfam04156 813012134 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 813012135 elongation factor P; Provisional; Region: PRK12426 813012136 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813012137 RNA binding site [nucleotide binding]; other site 813012138 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 813012139 RNA binding site [nucleotide binding]; other site 813012140 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 813012141 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 813012142 carboxyltransferase (CT) interaction site; other site 813012143 biotinylation site [posttranslational modification]; other site 813012144 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 813012145 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 813012146 ATP-grasp domain; Region: ATP-grasp_4; cl17255 813012147 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 813012148 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 813012149 23S rRNA interface [nucleotide binding]; other site 813012150 L3 interface [polypeptide binding]; other site 813012151 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 813012152 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 813012153 NlpC/P60 family; Region: NLPC_P60; cl17555 813012154 adenylate kinase; Reviewed; Region: adk; PRK00279 813012155 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 813012156 AMP-binding site [chemical binding]; other site 813012157 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 813012158 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 813012159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813012160 dimer interface [polypeptide binding]; other site 813012161 conserved gate region; other site 813012162 putative PBP binding loops; other site 813012163 ABC-ATPase subunit interface; other site 813012164 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 813012165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813012166 Walker A/P-loop; other site 813012167 ATP binding site [chemical binding]; other site 813012168 Q-loop/lid; other site 813012169 ABC transporter signature motif; other site 813012170 Walker B; other site 813012171 D-loop; other site 813012172 H-loop/switch region; other site 813012173 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 813012174 Methyltransferase domain; Region: Methyltransf_23; pfam13489 813012175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813012176 S-adenosylmethionine binding site [chemical binding]; other site 813012177 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 813012178 Serine hydrolase (FSH1); Region: FSH1; pfam03959 813012179 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 813012180 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 813012181 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 813012182 active site 813012183 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 813012184 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 813012185 conserved hypothetical integral membrane protein; Region: TIGR00697 813012186 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 813012187 SEC-C motif; Region: SEC-C; pfam02810 813012188 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 813012189 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813012190 active site 813012191 ATP binding site [chemical binding]; other site 813012192 substrate binding site [chemical binding]; other site 813012193 activation loop (A-loop); other site 813012194 Uncharacterized conserved protein [Function unknown]; Region: COG1262 813012195 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 813012196 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 813012197 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 813012198 nucleotide binding pocket [chemical binding]; other site 813012199 K-X-D-G motif; other site 813012200 catalytic site [active] 813012201 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 813012202 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 813012203 Helix-hairpin-helix motif; Region: HHH; pfam00633 813012204 helix-hairpin-helix signature motif; other site 813012205 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 813012206 Dimer interface [polypeptide binding]; other site 813012207 BRCT sequence motif; other site 813012208 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 813012209 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 813012210 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 813012211 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 813012212 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 813012213 FtsX-like permease family; Region: FtsX; pfam02687 813012214 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 813012215 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 813012216 Walker A/P-loop; other site 813012217 ATP binding site [chemical binding]; other site 813012218 Q-loop/lid; other site 813012219 ABC transporter signature motif; other site 813012220 Walker B; other site 813012221 D-loop; other site 813012222 H-loop/switch region; other site 813012223 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813012224 PLD-like domain; Region: PLDc_2; pfam13091 813012225 putative active site [active] 813012226 catalytic site [active] 813012227 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813012228 PLD-like domain; Region: PLDc_2; pfam13091 813012229 putative active site [active] 813012230 catalytic site [active] 813012231 trp operon repressor, proteobacterial; Region: TrpR; TIGR01321 813012232 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 813012233 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 813012234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813012235 catalytic residue [active] 813012236 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 813012237 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 813012238 substrate binding site [chemical binding]; other site 813012239 active site 813012240 catalytic residues [active] 813012241 heterodimer interface [polypeptide binding]; other site 813012242 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 813012243 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 813012244 peptide binding site [polypeptide binding]; other site 813012245 putative disulfide oxidoreductase; Provisional; Region: PRK00611 813012246 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 813012247 putative active site [active] 813012248 redox center [active] 813012249 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 813012250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813012251 Walker A/P-loop; other site 813012252 ATP binding site [chemical binding]; other site 813012253 Q-loop/lid; other site 813012254 ABC transporter signature motif; other site 813012255 Walker B; other site 813012256 D-loop; other site 813012257 H-loop/switch region; other site 813012258 CTP synthetase; Validated; Region: pyrG; PRK05380 813012259 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 813012260 Catalytic site [active] 813012261 active site 813012262 UTP binding site [chemical binding]; other site 813012263 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 813012264 active site 813012265 putative oxyanion hole; other site 813012266 catalytic triad [active] 813012267 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 813012268 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 813012269 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 813012270 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 813012271 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 813012272 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 813012273 putative active site [active] 813012274 DNA polymerase III subunit delta'; Validated; Region: PRK05917 813012275 DNA polymerase III subunit delta'; Validated; Region: PRK08485 813012276 thymidylate kinase; Validated; Region: tmk; PRK00698 813012277 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 813012278 TMP-binding site; other site 813012279 ATP-binding site [chemical binding]; other site 813012280 DNA gyrase, A subunit; Region: gyrA; TIGR01063 813012281 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 813012282 CAP-like domain; other site 813012283 active site 813012284 primary dimer interface [polypeptide binding]; other site 813012285 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813012286 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813012287 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813012288 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813012289 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813012290 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813012291 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 813012292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813012293 ATP binding site [chemical binding]; other site 813012294 Mg2+ binding site [ion binding]; other site 813012295 G-X-G motif; other site 813012296 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 813012297 anchoring element; other site 813012298 dimer interface [polypeptide binding]; other site 813012299 ATP binding site [chemical binding]; other site 813012300 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 813012301 active site 813012302 putative metal-binding site [ion binding]; other site 813012303 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 813012304 Protein of unknown function (DUF721); Region: DUF721; pfam05258 813012305 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 813012306 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 813012307 UGMP family protein; Validated; Region: PRK09604 813012308 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 813012309 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 813012310 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 813012311 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 813012312 peptide binding site [polypeptide binding]; other site 813012313 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 813012314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813012315 dimer interface [polypeptide binding]; other site 813012316 conserved gate region; other site 813012317 putative PBP binding loops; other site 813012318 ABC-ATPase subunit interface; other site 813012319 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 813012320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813012321 dimer interface [polypeptide binding]; other site 813012322 conserved gate region; other site 813012323 putative PBP binding loops; other site 813012324 ABC-ATPase subunit interface; other site 813012325 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813012326 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 813012327 Walker A/P-loop; other site 813012328 ATP binding site [chemical binding]; other site 813012329 Q-loop/lid; other site 813012330 ABC transporter signature motif; other site 813012331 Walker B; other site 813012332 D-loop; other site 813012333 H-loop/switch region; other site 813012334 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 813012335 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 813012336 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813012337 Walker A/P-loop; other site 813012338 ATP binding site [chemical binding]; other site 813012339 Q-loop/lid; other site 813012340 ABC transporter signature motif; other site 813012341 Walker B; other site 813012342 D-loop; other site 813012343 H-loop/switch region; other site 813012344 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813012345 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 813012346 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 813012347 transmembrane helices; other site 813012348 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 813012349 active site 813012350 ADP/pyrophosphate binding site [chemical binding]; other site 813012351 dimerization interface [polypeptide binding]; other site 813012352 allosteric effector site; other site 813012353 fructose-1,6-bisphosphate binding site; other site 813012354 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 813012355 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 813012356 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 813012357 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 813012358 active site 813012359 ADP/pyrophosphate binding site [chemical binding]; other site 813012360 dimerization interface [polypeptide binding]; other site 813012361 allosteric effector site; other site 813012362 fructose-1,6-bisphosphate binding site; other site 813012363 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 813012364 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 813012365 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 813012366 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 813012367 HIGH motif; other site 813012368 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 813012369 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 813012370 active site 813012371 KMSKS motif; other site 813012372 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 813012373 tRNA binding surface [nucleotide binding]; other site 813012374 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00615 813012375 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 813012376 inhibitor-cofactor binding pocket; inhibition site 813012377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813012378 catalytic residue [active] 813012379 Putative transcriptional regulator [Transcription]; Region: COG1678 813012380 Uncharacterized conserved protein [Function unknown]; Region: COG1259 813012381 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 813012382 tetramer (dimer of dimers) interface [polypeptide binding]; other site 813012383 active site 813012384 dimer interface [polypeptide binding]; other site 813012385 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 813012386 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 813012387 putative active site; other site 813012388 catalytic residue [active] 813012389 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 813012390 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 813012391 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 813012392 Ligand Binding Site [chemical binding]; other site 813012393 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 813012394 prenyltransferase; Reviewed; Region: ubiA; PRK12876 813012395 UbiA prenyltransferase family; Region: UbiA; pfam01040 813012396 aromatic acid decarboxylase; Validated; Region: PRK05920 813012397 Flavoprotein; Region: Flavoprotein; pfam02441 813012398 Uncharacterized conserved protein [Function unknown]; Region: COG1284 813012399 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 813012400 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813012401 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 813012402 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 813012403 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 813012404 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 813012405 Na2 binding site [ion binding]; other site 813012406 putative substrate binding site 1 [chemical binding]; other site 813012407 Na binding site 1 [ion binding]; other site 813012408 putative substrate binding site 2 [chemical binding]; other site 813012409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813012410 putative substrate translocation pore; other site 813012411 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 813012412 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 813012413 ligand binding site [chemical binding]; other site 813012414 flexible hinge region; other site 813012415 acyl carrier protein; Provisional; Region: acpP; PRK00982 813012416 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 813012417 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 813012418 NAD(P) binding site [chemical binding]; other site 813012419 homotetramer interface [polypeptide binding]; other site 813012420 homodimer interface [polypeptide binding]; other site 813012421 active site 813012422 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 813012423 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 813012424 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 813012425 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 813012426 dimer interface [polypeptide binding]; other site 813012427 active site 813012428 CoA binding pocket [chemical binding]; other site 813012429 recombination protein RecR; Region: recR; TIGR00615 813012430 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 813012431 putative active site [active] 813012432 putative metal-binding site [ion binding]; other site 813012433 tetramer interface [polypeptide binding]; other site 813012434 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 813012435 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813012436 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813012437 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813012438 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813012439 Surface antigen; Region: Bac_surface_Ag; pfam01103 813012440 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 813012441 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 813012442 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 813012443 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 813012444 trimer interface [polypeptide binding]; other site 813012445 active site 813012446 UDP-GlcNAc binding site [chemical binding]; other site 813012447 lipid binding site [chemical binding]; lipid-binding site 813012448 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 813012449 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 813012450 tetramer interface [polypeptide binding]; other site 813012451 TPP-binding site [chemical binding]; other site 813012452 heterodimer interface [polypeptide binding]; other site 813012453 phosphorylation loop region [posttranslational modification] 813012454 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 813012455 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 813012456 alpha subunit interface [polypeptide binding]; other site 813012457 TPP binding site [chemical binding]; other site 813012458 heterodimer interface [polypeptide binding]; other site 813012459 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813012460 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 813012461 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813012462 E3 interaction surface; other site 813012463 lipoyl attachment site [posttranslational modification]; other site 813012464 e3 binding domain; Region: E3_binding; pfam02817 813012465 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813012466 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 813012467 homodimer interface [polypeptide binding]; other site 813012468 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 813012469 active site pocket [active] 813012470 chromosomal replication initiation protein; Provisional; Region: PRK12422 813012471 DnaA N-terminal domain; Region: DnaA_N; pfam11638 813012472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813012473 Walker A motif; other site 813012474 ATP binding site [chemical binding]; other site 813012475 Walker B motif; other site 813012476 arginine finger; other site 813012477 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 813012478 DnaA box-binding interface [nucleotide binding]; other site 813012479 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 813012480 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 813012481 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 813012482 CAAX protease self-immunity; Region: Abi; pfam02517 813012483 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 813012484 homodimer interface [polypeptide binding]; other site 813012485 metal binding site [ion binding]; metal-binding site 813012486 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 813012487 Domain of unknown function DUF21; Region: DUF21; pfam01595 813012488 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813012489 Transporter associated domain; Region: CorC_HlyC; smart01091 813012490 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 813012491 Domain of unknown function DUF21; Region: DUF21; pfam01595 813012492 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813012493 Transporter associated domain; Region: CorC_HlyC; smart01091 813012494 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 813012495 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 813012496 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813012497 catalytic residue [active] 813012498 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 813012499 Protein phosphatase 2C; Region: PP2C; pfam00481 813012500 active site 813012501 Uncharacterized conserved protein [Function unknown]; Region: COG5465 813012502 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 813012503 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 813012504 active site 813012505 catalytic site [active] 813012506 substrate binding site [chemical binding]; other site 813012507 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 813012508 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 813012509 nucleosidase; Provisional; Region: PRK05634 813012510 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 813012511 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 813012512 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813012513 Walker A/P-loop; other site 813012514 ATP binding site [chemical binding]; other site 813012515 Q-loop/lid; other site 813012516 ABC transporter signature motif; other site 813012517 Walker B; other site 813012518 D-loop; other site 813012519 H-loop/switch region; other site 813012520 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 813012521 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 813012522 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 813012523 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 813012524 active site 813012525 metal binding site [ion binding]; metal-binding site 813012526 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 813012527 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 813012528 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813012529 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813012530 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 813012531 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 813012532 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 813012533 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 813012534 MraW methylase family; Region: Methyltransf_5; pfam01795 813012535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813012536 TPR motif; other site 813012537 binding surface 813012538 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 813012539 DnaA N-terminal domain; Region: DnaA_N; pfam11638 813012540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813012541 Walker A motif; other site 813012542 ATP binding site [chemical binding]; other site 813012543 Walker B motif; other site 813012544 arginine finger; other site 813012545 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 813012546 DnaA box-binding interface [nucleotide binding]; other site 813012547 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 813012548 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 813012549 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 813012550 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 813012551 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 813012552 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 813012553 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 813012554 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 813012555 lipoyl attachment site [posttranslational modification]; other site 813012556 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 813012557 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 813012558 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813012559 putative active site [active] 813012560 catalytic site [active] 813012561 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813012562 putative active site [active] 813012563 catalytic site [active] 813012564 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 813012565 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 813012566 Clp amino terminal domain; Region: Clp_N; pfam02861 813012567 Clp amino terminal domain; Region: Clp_N; pfam02861 813012568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813012569 Walker A motif; other site 813012570 ATP binding site [chemical binding]; other site 813012571 Walker B motif; other site 813012572 arginine finger; other site 813012573 UvrB/uvrC motif; Region: UVR; pfam02151 813012574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813012575 Walker A motif; other site 813012576 ATP binding site [chemical binding]; other site 813012577 Walker B motif; other site 813012578 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 813012579 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 813012580 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 813012581 Ligand Binding Site [chemical binding]; other site 813012582 Helix-turn-helix domain; Region: HTH_17; pfam12728 813012583 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 813012584 active site 813012585 phosphorylation site [posttranslational modification] 813012586 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 813012587 active site 813012588 phosphorylation site [posttranslational modification] 813012589 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 813012590 trimer interface [polypeptide binding]; other site 813012591 active site 813012592 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 813012593 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 813012594 ribonuclease III; Reviewed; Region: rnc; PRK00102 813012595 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 813012596 dimerization interface [polypeptide binding]; other site 813012597 active site 813012598 metal binding site [ion binding]; metal-binding site 813012599 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 813012600 dsRNA binding site [nucleotide binding]; other site 813012601 DNA repair protein RadA; Provisional; Region: PRK11823 813012602 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 813012603 Walker A motif/ATP binding site; other site 813012604 ATP binding site [chemical binding]; other site 813012605 Walker B motif; other site 813012606 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 813012607 porphobilinogen deaminase; Provisional; Region: PRK01066 813012608 Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379 813012609 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 813012610 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813012611 active site 813012612 ATP binding site [chemical binding]; other site 813012613 substrate binding site [chemical binding]; other site 813012614 activation loop (A-loop); other site 813012615 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 813012616 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 813012617 HIGH motif; other site 813012618 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 813012619 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 813012620 active site 813012621 KMSKS motif; other site 813012622 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 813012623 tRNA binding surface [nucleotide binding]; other site 813012624 anticodon binding site; other site 813012625 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 813012626 V-type ATP synthase subunit K; Provisional; Region: PRK09621 813012627 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 813012628 V-type ATP synthase subunit I; Validated; Region: PRK05771 813012629 Protein of unknown function (DUF1319); Region: DUF1319; pfam07028 813012630 V-type ATP synthase subunit B; Provisional; Region: PRK02118 813012631 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813012632 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 813012633 Walker A motif homologous position; other site 813012634 Walker B motif; other site 813012635 V-type ATP synthase subunit A; Provisional; Region: PRK04192 813012636 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813012637 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 813012638 Walker A motif/ATP binding site; other site 813012639 Walker B motif; other site 813012640 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 813012641 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 813012642 V-type ATP synthase subunit E; Provisional; Region: PRK01005 813012643 V-type ATP synthase subunit E; Provisional; Region: PRK01558 813012644 transaldolase-like protein; Provisional; Region: PTZ00411 813012645 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 813012646 active site 813012647 dimer interface [polypeptide binding]; other site 813012648 catalytic residue [active] 813012649 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 813012650 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 813012651 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 813012652 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 813012653 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 813012654 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 813012655 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 813012656 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 813012657 DNA binding site [nucleotide binding] 813012658 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 813012659 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 813012660 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 813012661 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 813012662 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 813012663 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 813012664 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 813012665 RPB12 interaction site [polypeptide binding]; other site 813012666 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 813012667 RPB3 interaction site [polypeptide binding]; other site 813012668 RPB1 interaction site [polypeptide binding]; other site 813012669 RPB11 interaction site [polypeptide binding]; other site 813012670 RPB10 interaction site [polypeptide binding]; other site 813012671 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 813012672 L11 interface [polypeptide binding]; other site 813012673 putative EF-Tu interaction site [polypeptide binding]; other site 813012674 putative EF-G interaction site [polypeptide binding]; other site 813012675 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 813012676 23S rRNA interface [nucleotide binding]; other site 813012677 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 813012678 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 813012679 mRNA/rRNA interface [nucleotide binding]; other site 813012680 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 813012681 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 813012682 putative thiostrepton binding site; other site 813012683 23S rRNA interface [nucleotide binding]; other site 813012684 L7/L12 interface [polypeptide binding]; other site 813012685 L25 interface [polypeptide binding]; other site 813012686 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 813012687 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 813012688 putative homodimer interface [polypeptide binding]; other site 813012689 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 813012690 heterodimer interface [polypeptide binding]; other site 813012691 homodimer interface [polypeptide binding]; other site 813012692 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 813012693 elongation factor Tu; Reviewed; Region: PRK12735 813012694 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 813012695 G1 box; other site 813012696 GEF interaction site [polypeptide binding]; other site 813012697 GTP/Mg2+ binding site [chemical binding]; other site 813012698 Switch I region; other site 813012699 G2 box; other site 813012700 G3 box; other site 813012701 Switch II region; other site 813012702 G4 box; other site 813012703 G5 box; other site 813012704 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 813012705 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 813012706 Antibiotic Binding Site [chemical binding]; other site 813012707 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 813012708 rRNA binding site [nucleotide binding]; other site 813012709 predicted 30S ribosome binding site; other site 813012710 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 813012711 Protein of unknown function (DUF687); Region: DUF687; pfam05095 813012712 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 813012713 active site 813012714 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 813012715 triosephosphate isomerase; Provisional; Region: PRK14565 813012716 substrate binding site [chemical binding]; other site 813012717 dimer interface [polypeptide binding]; other site 813012718 catalytic triad [active] 813012719 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 813012720 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 813012721 generic binding surface II; other site 813012722 generic binding surface I; other site 813012723 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 813012724 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 813012725 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 813012726 TPP-binding site [chemical binding]; other site 813012727 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 813012728 PYR/PP interface [polypeptide binding]; other site 813012729 dimer interface [polypeptide binding]; other site 813012730 TPP binding site [chemical binding]; other site 813012731 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813012732 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 813012733 pyruvate kinase; Region: pyruv_kin; TIGR01064 813012734 domain interfaces; other site 813012735 active site 813012736 excinuclease ABC subunit A; Provisional; Region: PRK00635 813012737 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 813012738 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 813012739 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 813012740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813012741 Walker A/P-loop; other site 813012742 ATP binding site [chemical binding]; other site 813012743 Q-loop/lid; other site 813012744 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813012745 ABC transporter signature motif; other site 813012746 Walker B; other site 813012747 D-loop; other site 813012748 H-loop/switch region; other site 813012749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813012750 Walker A/P-loop; other site 813012751 ATP binding site [chemical binding]; other site 813012752 Q-loop/lid; other site 813012753 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813012754 Q-loop/lid; other site 813012755 ABC transporter signature motif; other site 813012756 Walker B; other site 813012757 D-loop; other site 813012758 H-loop/switch region; other site 813012759 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 813012760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813012761 Walker A motif; other site 813012762 ATP binding site [chemical binding]; other site 813012763 Walker B motif; other site 813012764 arginine finger; other site 813012765 hypothetical protein; Validated; Region: PRK00153 813012766 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 813012767 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 813012768 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 813012769 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 813012770 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 813012771 Competence protein; Region: Competence; pfam03772 813012772 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 813012773 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 813012774 tetramer interface [polypeptide binding]; other site 813012775 TPP-binding site [chemical binding]; other site 813012776 heterodimer interface [polypeptide binding]; other site 813012777 phosphorylation loop region [posttranslational modification] 813012778 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 813012779 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 813012780 alpha subunit interface [polypeptide binding]; other site 813012781 TPP binding site [chemical binding]; other site 813012782 heterodimer interface [polypeptide binding]; other site 813012783 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813012784 chaperone protein DnaJ; Provisional; Region: PRK14284 813012785 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 813012786 HSP70 interaction site [polypeptide binding]; other site 813012787 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 813012788 Zn binding sites [ion binding]; other site 813012789 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 813012790 dimer interface [polypeptide binding]; other site 813012791 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 813012792 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 813012793 Glycoprotease family; Region: Peptidase_M22; pfam00814 813012794 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 813012795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813012796 Walker A motif; other site 813012797 ATP binding site [chemical binding]; other site 813012798 Walker B motif; other site 813012799 arginine finger; other site 813012800 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 813012801 ribonuclease Z; Region: RNase_Z; TIGR02651 813012802 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 813012803 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 813012804 active site 813012805 Int/Topo IB signature motif; other site 813012806 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 813012807 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813012808 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813012809 ABC transporter; Region: ABC_tran_2; pfam12848 813012810 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813012811 Maf-like protein; Region: Maf; pfam02545 813012812 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 813012813 active site 813012814 dimer interface [polypeptide binding]; other site 813012815 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 813012816 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 813012817 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 813012818 active site 813012819 catalytic residues [active] 813012820 metal binding site [ion binding]; metal-binding site 813012821 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 813012822 dimethyladenosine transferase; Region: ksgA; TIGR00755 813012823 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 813012824 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 813012825 catalytic residues [active] 813012826 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 813012827 dihydrodipicolinate synthase; Region: dapA; TIGR00674 813012828 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 813012829 inhibitor site; inhibition site 813012830 active site 813012831 dimer interface [polypeptide binding]; other site 813012832 catalytic residue [active] 813012833 aspartate kinase; Provisional; Region: PRK05925 813012834 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 813012835 putative catalytic residues [active] 813012836 nucleotide binding site [chemical binding]; other site 813012837 aspartate binding site [chemical binding]; other site 813012838 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 813012839 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 813012840 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 813012841 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 813012842 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 813012843 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 813012844 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 813012845 hinge; other site 813012846 active site 813012847 shikimate kinase; Provisional; Region: PRK00625 813012848 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 813012849 ADP binding site [chemical binding]; other site 813012850 magnesium binding site [ion binding]; other site 813012851 putative shikimate binding site; other site 813012852 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 813012853 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 813012854 Tetramer interface [polypeptide binding]; other site 813012855 active site 813012856 FMN-binding site [chemical binding]; other site 813012857 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 813012858 active site 813012859 dimer interface [polypeptide binding]; other site 813012860 metal binding site [ion binding]; metal-binding site 813012861 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 813012862 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 813012863 active site 813012864 catalytic residue [active] 813012865 dimer interface [polypeptide binding]; other site 813012866 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 813012867 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 813012868 shikimate binding site; other site 813012869 NAD(P) binding site [chemical binding]; other site 813012870 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 813012871 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 813012872 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 813012873 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 813012874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 813012875 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 813012876 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 813012877 active site 813012878 dimer interface [polypeptide binding]; other site 813012879 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 813012880 dimer interface [polypeptide binding]; other site 813012881 active site 813012882 GTPases [General function prediction only]; Region: HflX; COG2262 813012883 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 813012884 HflX GTPase family; Region: HflX; cd01878 813012885 G1 box; other site 813012886 GTP/Mg2+ binding site [chemical binding]; other site 813012887 Switch I region; other site 813012888 G2 box; other site 813012889 G3 box; other site 813012890 Switch II region; other site 813012891 G4 box; other site 813012892 G5 box; other site 813012893 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 813012894 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 813012895 substrate binding pocket [chemical binding]; other site 813012896 membrane-bound complex binding site; other site 813012897 hinge residues; other site 813012898 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 813012899 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 813012900 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 813012901 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 813012902 nucleotide binding site/active site [active] 813012903 Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286 813012904 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 813012905 hypothetical protein; Validated; Region: PRK00647 813012906 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 813012907 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 813012908 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 813012909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813012910 homodimer interface [polypeptide binding]; other site 813012911 catalytic residue [active] 813012912 ABC transporter substrate binding protein; Region: ABC_sub_bind; pfam04392 813012913 prolyl-tRNA synthetase; Provisional; Region: PRK09194 813012914 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 813012915 dimer interface [polypeptide binding]; other site 813012916 motif 1; other site 813012917 active site 813012918 motif 2; other site 813012919 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 813012920 putative deacylase active site [active] 813012921 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813012922 active site 813012923 motif 3; other site 813012924 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 813012925 anticodon binding site; other site 813012926 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 813012927 GrpE; Region: GrpE; pfam01025 813012928 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 813012929 dimer interface [polypeptide binding]; other site 813012930 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 813012931 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 813012932 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 813012933 nucleotide binding site [chemical binding]; other site 813012934 NEF interaction site [polypeptide binding]; other site 813012935 SBD interface [polypeptide binding]; other site 813012936 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 813012937 Exoribonuclease R [Transcription]; Region: VacB; COG0557 813012938 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 813012939 RNB domain; Region: RNB; pfam00773 813012940 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 813012941 Putative zinc ribbon domain; Region: DUF164; pfam02591 813012942 KpsF/GutQ family protein; Region: kpsF; TIGR00393 813012943 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 813012944 putative active site [active] 813012945 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 813012946 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 813012947 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813012948 E3 interaction surface; other site 813012949 lipoyl attachment site [posttranslational modification]; other site 813012950 e3 binding domain; Region: E3_binding; pfam02817 813012951 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813012952 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 813012953 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 813012954 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 813012955 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 813012956 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 813012957 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 813012958 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 813012959 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 813012960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813012961 S-adenosylmethionine binding site [chemical binding]; other site 813012962 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 813012963 Lumazine binding domain; Region: Lum_binding; pfam00677 813012964 Lumazine binding domain; Region: Lum_binding; pfam00677 813012965 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 813012966 ATP cone domain; Region: ATP-cone; pfam03477 813012967 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 813012968 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 813012969 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 813012970 amino acid carrier protein; Region: agcS; TIGR00835 813012971 poly(A) polymerase; Region: pcnB; TIGR01942 813012972 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 813012973 active site 813012974 NTP binding site [chemical binding]; other site 813012975 metal binding triad [ion binding]; metal-binding site 813012976 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 813012977 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 813012978 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 813012979 Predicted membrane protein [Function unknown]; Region: COG3952 813012980 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 813012981 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813012982 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813012983 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813012984 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813012985 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813012986 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813012987 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813012988 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813012989 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 813012990 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 813012991 intersubunit interface [polypeptide binding]; other site 813012992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813012993 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 813012994 Walker A/P-loop; other site 813012995 ATP binding site [chemical binding]; other site 813012996 Q-loop/lid; other site 813012997 ABC transporter signature motif; other site 813012998 Walker B; other site 813012999 D-loop; other site 813013000 H-loop/switch region; other site 813013001 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813013002 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813013003 ABC-ATPase subunit interface; other site 813013004 dimer interface [polypeptide binding]; other site 813013005 putative PBP binding regions; other site 813013006 GTPase CgtA; Reviewed; Region: obgE; PRK12299 813013007 GTP1/OBG; Region: GTP1_OBG; pfam01018 813013008 Obg GTPase; Region: Obg; cd01898 813013009 G1 box; other site 813013010 GTP/Mg2+ binding site [chemical binding]; other site 813013011 Switch I region; other site 813013012 G2 box; other site 813013013 G3 box; other site 813013014 Switch II region; other site 813013015 G4 box; other site 813013016 G5 box; other site 813013017 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 813013018 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 813013019 Uncharacterized conserved protein [Function unknown]; Region: COG2928 813013020 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 813013021 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 813013022 FOG: CBS domain [General function prediction only]; Region: COG0517 813013023 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813013024 Transporter associated domain; Region: CorC_HlyC; smart01091 813013025 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 813013026 anti sigma factor interaction site; other site 813013027 regulatory phosphorylation site [posttranslational modification]; other site 813013028 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 813013029 hypothetical protein; Provisional; Region: PRK05926 813013030 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813013031 FeS/SAM binding site; other site 813013032 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 813013033 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 813013034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813013035 S-adenosylmethionine binding site [chemical binding]; other site 813013036 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 813013037 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 813013038 diaminopimelate epimerase; Region: DapF; TIGR00652 813013039 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 813013040 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 813013041 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 813013042 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 813013043 active site 813013044 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 813013045 homotrimer interaction site [polypeptide binding]; other site 813013046 zinc binding site [ion binding]; other site 813013047 CDP-binding sites; other site 813013048 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 813013049 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 813013050 FAD binding pocket [chemical binding]; other site 813013051 conserved FAD binding motif [chemical binding]; other site 813013052 phosphate binding motif [ion binding]; other site 813013053 beta-alpha-beta structure motif; other site 813013054 NAD binding pocket [chemical binding]; other site 813013055 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 813013056 elongation factor G; Reviewed; Region: PRK12739 813013057 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 813013058 G1 box; other site 813013059 putative GEF interaction site [polypeptide binding]; other site 813013060 GTP/Mg2+ binding site [chemical binding]; other site 813013061 Switch I region; other site 813013062 G2 box; other site 813013063 G3 box; other site 813013064 Switch II region; other site 813013065 G4 box; other site 813013066 G5 box; other site 813013067 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 813013068 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 813013069 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 813013070 30S ribosomal protein S7; Validated; Region: PRK05302 813013071 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 813013072 S17 interaction site [polypeptide binding]; other site 813013073 S8 interaction site; other site 813013074 16S rRNA interaction site [nucleotide binding]; other site 813013075 streptomycin interaction site [chemical binding]; other site 813013076 23S rRNA interaction site [nucleotide binding]; other site 813013077 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 813013078 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 813013079 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 813013080 protein binding site [polypeptide binding]; other site 813013081 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 813013082 Catalytic dyad [active] 813013083 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 813013084 Domain of unknown function DUF11; Region: DUF11; pfam01345 813013085 Domain of unknown function DUF11; Region: DUF11; pfam01345 813013086 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 813013087 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 813013088 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 813013089 HIGH motif; other site 813013090 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 813013091 active site 813013092 KMSKS motif; other site 813013093 Helix-turn-helix domain; Region: HTH_17; pfam12728 813013094 Helix-turn-helix domain; Region: HTH_17; pfam12728 813013095 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 813013096 DHH family; Region: DHH; pfam01368 813013097 DHHA1 domain; Region: DHHA1; pfam02272 813013098 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 813013099 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 813013100 Protein export membrane protein; Region: SecD_SecF; pfam02355 813013101 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 813013102 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 813013103 catalytic residue [active] 813013104 putative FPP diphosphate binding site; other site 813013105 putative FPP binding hydrophobic cleft; other site 813013106 dimer interface [polypeptide binding]; other site 813013107 putative IPP diphosphate binding site; other site 813013108 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 813013109 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 813013110 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 813013111 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 813013112 CMP-binding site; other site 813013113 The sites determining sugar specificity; other site 813013114 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 813013115 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 813013116 putative acyl-acceptor binding pocket; other site 813013117 arginine-tRNA ligase; Region: PLN02286 813013118 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 813013119 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 813013120 active site 813013121 HIGH motif; other site 813013122 KMSK motif region; other site 813013123 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813013124 tRNA binding surface [nucleotide binding]; other site 813013125 anticodon binding site; other site 813013126 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 813013127 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 813013128 hinge; other site 813013129 active site 813013130 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 813013131 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 813013132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 813013133 Coenzyme A binding pocket [chemical binding]; other site 813013134 PCRF domain; Region: PCRF; pfam03462 813013135 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 813013136 RF-1 domain; Region: RF-1; pfam00472 813013137 SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531 813013138 SWI complex, BAF60b domains; Region: SWIB; smart00151 813013139 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 813013140 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813013141 putative active site [active] 813013142 putative metal binding site [ion binding]; other site 813013143 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 813013144 substrate binding site; other site 813013145 dimer interface; other site 813013146 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 813013147 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 813013148 dimerization interface 3.5A [polypeptide binding]; other site 813013149 active site 813013150 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 813013151 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 813013152 active site 813013153 motif I; other site 813013154 motif II; other site 813013155 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 813013156 PAS domain; Region: PAS; smart00091 813013157 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 813013158 dimer interface [polypeptide binding]; other site 813013159 phosphorylation site [posttranslational modification] 813013160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813013161 ATP binding site [chemical binding]; other site 813013162 Mg2+ binding site [ion binding]; other site 813013163 G-X-G motif; other site 813013164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 813013165 Response regulator receiver domain; Region: Response_reg; pfam00072 813013166 active site 813013167 phosphorylation site [posttranslational modification] 813013168 intermolecular recognition site; other site 813013169 dimerization interface [polypeptide binding]; other site 813013170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813013171 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 813013172 Walker A motif; other site 813013173 ATP binding site [chemical binding]; other site 813013174 Walker B motif; other site 813013175 arginine finger; other site 813013176 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 813013177 Recombination protein O N terminal; Region: RecO_N; pfam11967 813013178 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 813013179 Recombination protein O C terminal; Region: RecO_C; pfam02565 813013180 Uncharacterized conserved protein [Function unknown]; Region: COG1723 813013181 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 813013182 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 813013183 putative tRNA-binding site [nucleotide binding]; other site 813013184 B3/4 domain; Region: B3_4; pfam03483 813013185 tRNA synthetase B5 domain; Region: B5; smart00874 813013186 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 813013187 dimer interface [polypeptide binding]; other site 813013188 motif 1; other site 813013189 motif 3; other site 813013190 motif 2; other site 813013191 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 813013192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813013193 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 813013194 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 813013195 DNA binding site [nucleotide binding] 813013196 active site 813013197 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 813013198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813013199 dimer interface [polypeptide binding]; other site 813013200 conserved gate region; other site 813013201 putative PBP binding loops; other site 813013202 ABC-ATPase subunit interface; other site 813013203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 813013204 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 813013205 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 813013206 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 813013207 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 813013208 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 813013209 putative active site [active] 813013210 putative metal binding site [ion binding]; other site 813013211 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813013212 binding surface 813013213 TPR motif; other site 813013214 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 813013215 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 813013216 C-terminal domain interface [polypeptide binding]; other site 813013217 active site 813013218 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 813013219 active site 813013220 N-terminal domain interface [polypeptide binding]; other site 813013221 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 813013222 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 813013223 substrate binding pocket [chemical binding]; other site 813013224 membrane-bound complex binding site; other site 813013225 hinge residues; other site 813013226 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 813013227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813013228 S-adenosylmethionine binding site [chemical binding]; other site 813013229 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 813013230 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813013231 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 813013232 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 813013233 ligand binding site; other site 813013234 oligomer interface; other site 813013235 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 813013236 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 813013237 N-terminal domain interface [polypeptide binding]; other site 813013238 sulfate 1 binding site; other site 813013239 transcription termination factor Rho; Region: rho; TIGR00767 813013240 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 813013241 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 813013242 RNA binding site [nucleotide binding]; other site 813013243 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 813013244 multimer interface [polypeptide binding]; other site 813013245 Walker A motif; other site 813013246 ATP binding site [chemical binding]; other site 813013247 Walker B motif; other site 813013248 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 813013249 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 813013250 CoA-binding site [chemical binding]; other site 813013251 ATP-binding [chemical binding]; other site 813013252 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 813013253 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 813013254 tandem repeat interface [polypeptide binding]; other site 813013255 oligomer interface [polypeptide binding]; other site 813013256 active site residues [active] 813013257 TLC ATP/ADP transporter; Region: TLC; pfam03219 813013258 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 813013259 replicative DNA helicase; Provisional; Region: PRK06321 813013260 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 813013261 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 813013262 Walker A motif; other site 813013263 ATP binding site [chemical binding]; other site 813013264 Walker B motif; other site 813013265 DNA binding loops [nucleotide binding] 813013266 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 813013267 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 813013268 RuvA N terminal domain; Region: RuvA_N; pfam01330 813013269 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 813013270 active site 813013271 putative DNA-binding cleft [nucleotide binding]; other site 813013272 dimer interface [polypeptide binding]; other site 813013273 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 813013274 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 813013275 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 813013276 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 813013277 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 813013278 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 813013279 alphaNTD - beta interaction site [polypeptide binding]; other site 813013280 alphaNTD homodimer interface [polypeptide binding]; other site 813013281 alphaNTD - beta' interaction site [polypeptide binding]; other site 813013282 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 813013283 30S ribosomal protein S11; Validated; Region: PRK05309 813013284 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 813013285 30S ribosomal protein S13; Region: bact_S13; TIGR03631 813013286 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 813013287 SecY translocase; Region: SecY; pfam00344 813013288 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 813013289 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 813013290 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 813013291 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 813013292 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 813013293 5S rRNA interface [nucleotide binding]; other site 813013294 23S rRNA interface [nucleotide binding]; other site 813013295 L5 interface [polypeptide binding]; other site 813013296 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 813013297 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 813013298 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 813013299 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 813013300 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 813013301 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 813013302 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 813013303 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 813013304 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 813013305 RNA binding site [nucleotide binding]; other site 813013306 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 813013307 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 813013308 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 813013309 23S rRNA interface [nucleotide binding]; other site 813013310 putative translocon interaction site; other site 813013311 signal recognition particle (SRP54) interaction site; other site 813013312 L23 interface [polypeptide binding]; other site 813013313 trigger factor interaction site; other site 813013314 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 813013315 23S rRNA interface [nucleotide binding]; other site 813013316 5S rRNA interface [nucleotide binding]; other site 813013317 putative antibiotic binding site [chemical binding]; other site 813013318 L25 interface [polypeptide binding]; other site 813013319 L27 interface [polypeptide binding]; other site 813013320 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 813013321 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 813013322 G-X-X-G motif; other site 813013323 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 813013324 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 813013325 putative translocon binding site; other site 813013326 protein-rRNA interface [nucleotide binding]; other site 813013327 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 813013328 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 813013329 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 813013330 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 813013331 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 813013332 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 813013333 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 813013334 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 813013335 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 813013336 putative active site [active] 813013337 substrate binding site [chemical binding]; other site 813013338 putative cosubstrate binding site; other site 813013339 catalytic site [active] 813013340 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 813013341 substrate binding site [chemical binding]; other site 813013342 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 813013343 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 813013344 active site 813013345 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 813013346 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 813013347 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 813013348 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 813013349 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 813013350 putative active site [active] 813013351 catalytic triad [active] 813013352 putative dimer interface [polypeptide binding]; other site 813013353 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 813013354 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 813013355 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 813013356 active site 813013357 catalytic site [active] 813013358 substrate binding site [chemical binding]; other site 813013359 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 813013360 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 813013361 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 813013362 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 813013363 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813013364 catalytic residues [active] 813013365 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 813013366 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 813013367 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 813013368 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 813013369 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 813013370 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 813013371 dimer interface [polypeptide binding]; other site 813013372 anticodon binding site; other site 813013373 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 813013374 homodimer interface [polypeptide binding]; other site 813013375 motif 1; other site 813013376 active site 813013377 motif 2; other site 813013378 GAD domain; Region: GAD; pfam02938 813013379 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813013380 active site 813013381 motif 3; other site 813013382 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 813013383 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 813013384 dimer interface [polypeptide binding]; other site 813013385 motif 1; other site 813013386 active site 813013387 motif 2; other site 813013388 motif 3; other site 813013389 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 813013390 anticodon binding site; other site 813013391 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 813013392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813013393 putative substrate translocation pore; other site 813013394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813013395 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 813013396 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 813013397 active site 813013398 PHP Thumb interface [polypeptide binding]; other site 813013399 metal binding site [ion binding]; metal-binding site 813013400 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 813013401 generic binding surface I; other site 813013402 generic binding surface II; other site 813013403 TPR repeat; Region: TPR_11; pfam13414 813013404 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813013405 binding surface 813013406 TPR motif; other site 813013407 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 813013408 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 813013409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 813013410 Mg2+ binding site [ion binding]; other site 813013411 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 813013412 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 813013413 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 813013414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813013415 S-adenosylmethionine binding site [chemical binding]; other site 813013416 branched-chain amino acid uptake carrier; Region: livcs; TIGR00796 813013417 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 813013418 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813013419 ATP binding site [chemical binding]; other site 813013420 putative Mg++ binding site [ion binding]; other site 813013421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813013422 ATP-binding site [chemical binding]; other site 813013423 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 813013424 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 813013425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 813013426 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 813013427 lipoate synthase; Region: lipA; TIGR00510 813013428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813013429 FeS/SAM binding site; other site 813013430 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 813013431 type III secretion system protein; Validated; Region: PRK06328 813013432 Flagellar assembly protein FliH; Region: FliH; pfam02108 813013433 type III secretion system protein; Reviewed; Region: PRK09617 813013434 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 813013435 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 813013436 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 813013437 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 813013438 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 813013439 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 813013440 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 813013441 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 813013442 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 813013443 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 813013444 Walker A motif; other site 813013445 ATP binding site [chemical binding]; other site 813013446 Walker B motif; other site 813013447 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 813013448 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813013449 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 813013450 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 813013451 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 813013452 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 813013453 active site 813013454 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 813013455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813013456 ATP binding site [chemical binding]; other site 813013457 Mg2+ binding site [ion binding]; other site 813013458 G-X-G motif; other site 813013459 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 813013460 ATP binding site [chemical binding]; other site 813013461 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 813013462 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 813013463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813013464 binding surface 813013465 TPR motif; other site 813013466 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 813013467 EamA-like transporter family; Region: EamA; pfam00892 813013468 EamA-like transporter family; Region: EamA; pfam00892 813013469 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 813013470 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 813013471 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 813013472 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 813013473 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 813013474 active site 813013475 HIGH motif; other site 813013476 dimer interface [polypeptide binding]; other site 813013477 KMSKS motif; other site 813013478 excinuclease ABC subunit B; Provisional; Region: PRK05298 813013479 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813013480 ATP binding site [chemical binding]; other site 813013481 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813013482 nucleotide binding region [chemical binding]; other site 813013483 ATP-binding site [chemical binding]; other site 813013484 Ultra-violet resistance protein B; Region: UvrB; pfam12344 813013485 enolase; Provisional; Region: eno; PRK00077 813013486 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 813013487 dimer interface [polypeptide binding]; other site 813013488 metal binding site [ion binding]; metal-binding site 813013489 substrate binding pocket [chemical binding]; other site 813013490 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 813013491 HAMP domain; Region: HAMP; pfam00672 813013492 dimerization interface [polypeptide binding]; other site 813013493 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 813013494 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 813013495 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 813013496 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 813013497 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 813013498 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 813013499 Iron-sulfur protein interface; other site 813013500 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 813013501 proximal heme binding site [chemical binding]; other site 813013502 Iron-sulfur protein interface; other site 813013503 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 813013504 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 813013505 active site 813013506 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 813013507 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 813013508 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 813013509 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 813013510 DsbD alpha interface [polypeptide binding]; other site 813013511 catalytic residues [active] 813013512 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 813013513 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 813013514 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 813013515 translocation protein TolB; Provisional; Region: tolB; PRK01029 813013516 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813013517 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813013518 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813013519 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 813013520 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 813013521 ligand binding site [chemical binding]; other site 813013522 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 813013523 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813013524 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 813013525 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 813013526 dimer interface [polypeptide binding]; other site 813013527 decamer (pentamer of dimers) interface [polypeptide binding]; other site 813013528 catalytic triad [active] 813013529 peroxidatic and resolving cysteines [active] 813013530 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 813013531 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 813013532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 813013533 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 813013534 ligand binding site [chemical binding]; other site 813013535 active site 813013536 UGI interface [polypeptide binding]; other site 813013537 catalytic site [active] 813013538 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 813013539 Part of AAA domain; Region: AAA_19; pfam13245 813013540 Family description; Region: UvrD_C_2; pfam13538 813013541 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 813013542 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 813013543 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 813013544 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 813013545 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 813013546 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 813013547 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 813013548 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 813013549 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 813013550 folate binding site [chemical binding]; other site 813013551 NADP+ binding site [chemical binding]; other site 813013552 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 813013553 catalytic center binding site [active] 813013554 ATP binding site [chemical binding]; other site 813013555 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 813013556 dihydropteroate synthase; Region: DHPS; TIGR01496 813013557 substrate binding pocket [chemical binding]; other site 813013558 dimer interface [polypeptide binding]; other site 813013559 inhibitor binding site; inhibition site 813013560 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 813013561 homooctamer interface [polypeptide binding]; other site 813013562 active site 813013563 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 813013564 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 813013565 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 813013566 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 813013567 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 813013568 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 813013569 DNA binding residues [nucleotide binding] 813013570 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 813013571 Effector from type III secretion system; Region: Effector_1; pfam04518 813013572 Effector from type III secretion system; Region: Effector_1; pfam04518 813013573 Effector from type III secretion system; Region: Effector_1; pfam04518 813013574 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 813013575 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 813013576 MviN-like protein; Region: MVIN; pfam03023 813013577 endonuclease IV; Provisional; Region: PRK01060 813013578 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 813013579 AP (apurinic/apyrimidinic) site pocket; other site 813013580 DNA interaction; other site 813013581 Metal-binding active site; metal-binding site 813013582 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 813013583 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 813013584 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813013585 RNA binding surface [nucleotide binding]; other site 813013586 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 813013587 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 813013588 active site residue [active] 813013589 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 813013590 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 813013591 substrate binding pocket [chemical binding]; other site 813013592 chain length determination region; other site 813013593 substrate-Mg2+ binding site; other site 813013594 catalytic residues [active] 813013595 aspartate-rich region 1; other site 813013596 active site lid residues [active] 813013597 aspartate-rich region 2; other site 813013598 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 813013599 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 813013600 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 813013601 DNA binding site [nucleotide binding] 813013602 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 813013603 Thymidylate synthase complementing protein; Region: Thy1; cl03630 813013604 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 813013605 dimer interface [polypeptide binding]; other site 813013606 active site 813013607 aspartate-rich active site metal binding site; other site 813013608 allosteric magnesium binding site [ion binding]; other site 813013609 Schiff base residues; other site 813013610 NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit; Region: nqrA; TIGR01936 813013611 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 813013612 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 813013613 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 813013614 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 813013615 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 813013616 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 813013617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813013618 homodimer interface [polypeptide binding]; other site 813013619 catalytic residue [active] 813013620 rod shape-determining protein MreC; Provisional; Region: PRK14872 813013621 rod shape-determining protein MreC; Region: MreC; pfam04085 813013622 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 813013623 Part of AAA domain; Region: AAA_19; pfam13245 813013624 Family description; Region: UvrD_C_2; pfam13538 813013625 Major Facilitator Superfamily; Region: MFS_1; pfam07690 813013626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813013627 putative substrate translocation pore; other site 813013628 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 813013629 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 813013630 active site 813013631 interdomain interaction site; other site 813013632 putative metal-binding site [ion binding]; other site 813013633 nucleotide binding site [chemical binding]; other site 813013634 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 813013635 domain I; other site 813013636 DNA binding groove [nucleotide binding] 813013637 phosphate binding site [ion binding]; other site 813013638 domain II; other site 813013639 domain III; other site 813013640 nucleotide binding site [chemical binding]; other site 813013641 catalytic site [active] 813013642 domain IV; other site 813013643 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813013644 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813013645 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813013646 SWI complex, BAF60b domains; Region: SWIB; smart00151 813013647 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 813013648 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 813013649 FMN binding site [chemical binding]; other site 813013650 active site 813013651 catalytic residues [active] 813013652 substrate binding site [chemical binding]; other site 813013653 Predicted integral membrane protein [Function unknown]; Region: COG0762 813013654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813013655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813013656 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 813013657 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 813013658 recombinase A; Provisional; Region: recA; PRK09354 813013659 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 813013660 hexamer interface [polypeptide binding]; other site 813013661 Walker A motif; other site 813013662 ATP binding site [chemical binding]; other site 813013663 Walker B motif; other site 813013664 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 813013665 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 813013666 AAA domain; Region: AAA_30; pfam13604 813013667 Family description; Region: UvrD_C_2; pfam13538 813013668 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 813013669 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 813013670 Walker A/P-loop; other site 813013671 ATP binding site [chemical binding]; other site 813013672 Q-loop/lid; other site 813013673 ABC transporter signature motif; other site 813013674 Walker B; other site 813013675 D-loop; other site 813013676 H-loop/switch region; other site 813013677 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 813013678 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 813013679 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 813013680 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 813013681 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813013682 RNA binding surface [nucleotide binding]; other site 813013683 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 813013684 active site 813013685 hypothetical protein; Provisional; Region: PRK01064 813013686 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 813013687 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 813013688 DNA Topoisomerase IV; Region: TOP4c; smart00434 813013689 CAP-like domain; other site 813013690 active site 813013691 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 813013692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813013693 ATP binding site [chemical binding]; other site 813013694 Mg2+ binding site [ion binding]; other site 813013695 G-X-G motif; other site 813013696 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 813013697 ATP binding site [chemical binding]; other site 813013698 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 813013699 active site 813013700 putative metal-binding site [ion binding]; other site 813013701 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 813013702 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 813013703 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 813013704 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813013705 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 813013706 phosphopeptide binding site; other site 813013707 MARCKS family; Region: MARCKS; pfam02063 813013708 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 813013709 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 813013710 phosphopeptide binding site; other site 813013711 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 813013712 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 813013713 binding surface 813013714 Tetratricopeptide repeat; Region: TPR_16; pfam13432 813013715 TPR motif; other site 813013716 type III secretion system ATPase; Provisional; Region: PRK06315 813013717 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813013718 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 813013719 Walker A motif/ATP binding site; other site 813013720 Walker B motif; other site 813013721 type III secretion system protein; Validated; Region: PRK05933 813013722 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 813013723 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 813013724 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813013725 active site 813013726 ATP binding site [chemical binding]; other site 813013727 substrate binding site [chemical binding]; other site 813013728 activation loop (A-loop); other site 813013729 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 813013730 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813013731 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813013732 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 813013733 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 813013734 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 813013735 ADP binding site [chemical binding]; other site 813013736 phosphagen binding site; other site 813013737 substrate specificity loop; other site 813013738 ribosome recycling factor; Reviewed; Region: frr; PRK00083 813013739 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 813013740 hinge region; other site 813013741 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 813013742 putative nucleotide binding site [chemical binding]; other site 813013743 uridine monophosphate binding site [chemical binding]; other site 813013744 homohexameric interface [polypeptide binding]; other site 813013745 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 813013746 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 813013747 Elongation factor TS; Region: EF_TS; pfam00889 813013748 Elongation factor TS; Region: EF_TS; pfam00889 813013749 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 813013750 rRNA interaction site [nucleotide binding]; other site 813013751 S8 interaction site; other site 813013752 putative laminin-1 binding site; other site 813013753 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 813013754 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 813013755 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 813013756 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 813013757 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 813013758 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813013759 TPR motif; other site 813013760 Tetratricopeptide repeat; Region: TPR_16; pfam13432 813013761 binding surface 813013762 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813013763 binding surface 813013764 TPR motif; other site 813013765 TPR repeat; Region: TPR_11; pfam13414 813013766 TPR repeat; Region: TPR_11; pfam13414 813013767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813013768 binding surface 813013769 TPR motif; other site 813013770 TPR repeat; Region: TPR_11; pfam13414 813013771 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 813013772 putative ABC transporter; Region: ycf24; CHL00085 813013773 FeS assembly ATPase SufC; Region: sufC; TIGR01978 813013774 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 813013775 Walker A/P-loop; other site 813013776 ATP binding site [chemical binding]; other site 813013777 Q-loop/lid; other site 813013778 ABC transporter signature motif; other site 813013779 Walker B; other site 813013780 D-loop; other site 813013781 H-loop/switch region; other site 813013782 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 813013783 FeS assembly protein SufD; Region: sufD; TIGR01981 813013784 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 813013785 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 813013786 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813013787 catalytic residue [active] 813013788 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 813013789 ParB-like nuclease domain; Region: ParBc; pfam02195 813013790 KorB domain; Region: KorB; pfam08535 813013791 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813013792 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 813013793 Walker A/P-loop; other site 813013794 ATP binding site [chemical binding]; other site 813013795 Q-loop/lid; other site 813013796 ABC transporter signature motif; other site 813013797 Walker B; other site 813013798 D-loop; other site 813013799 H-loop/switch region; other site 813013800 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813013801 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 813013802 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813013803 Walker A/P-loop; other site 813013804 ATP binding site [chemical binding]; other site 813013805 Q-loop/lid; other site 813013806 ABC transporter signature motif; other site 813013807 Walker B; other site 813013808 D-loop; other site 813013809 H-loop/switch region; other site 813013810 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813013811 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 813013812 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 813013813 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 813013814 Phosphoglycerate kinase; Region: PGK; pfam00162 813013815 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 813013816 substrate binding site [chemical binding]; other site 813013817 hinge regions; other site 813013818 ADP binding site [chemical binding]; other site 813013819 catalytic site [active] 813013820 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 813013821 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 813013822 minor groove reading motif; other site 813013823 helix-hairpin-helix signature motif; other site 813013824 substrate binding pocket [chemical binding]; other site 813013825 active site 813013826 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 813013827 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 813013828 trmE is a tRNA modification GTPase; Region: trmE; cd04164 813013829 G1 box; other site 813013830 GTP/Mg2+ binding site [chemical binding]; other site 813013831 Switch I region; other site 813013832 G2 box; other site 813013833 Switch II region; other site 813013834 G3 box; other site 813013835 G4 box; other site 813013836 G5 box; other site 813013837 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 813013838 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 813013839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813013840 binding surface 813013841 TPR motif; other site 813013842 Predicted GTPases [General function prediction only]; Region: COG1160 813013843 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 813013844 G1 box; other site 813013845 GTP/Mg2+ binding site [chemical binding]; other site 813013846 Switch I region; other site 813013847 G2 box; other site 813013848 Switch II region; other site 813013849 G3 box; other site 813013850 G4 box; other site 813013851 G5 box; other site 813013852 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 813013853 G1 box; other site 813013854 GTP/Mg2+ binding site [chemical binding]; other site 813013855 Switch I region; other site 813013856 G2 box; other site 813013857 G3 box; other site 813013858 Switch II region; other site 813013859 G4 box; other site 813013860 G5 box; other site 813013861 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 813013862 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 813013863 active site 813013864 NTP binding site [chemical binding]; other site 813013865 metal binding triad [ion binding]; metal-binding site 813013866 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 813013867 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 813013868 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 813013869 oligomer interface [polypeptide binding]; other site 813013870 active site residues [active] 813013871 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 813013872 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 813013873 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 813013874 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 813013875 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813013876 ATP binding site [chemical binding]; other site 813013877 putative Mg++ binding site [ion binding]; other site 813013878 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813013879 nucleotide binding region [chemical binding]; other site 813013880 ATP-binding site [chemical binding]; other site 813013881 rod shape-determining protein MreB; Provisional; Region: PRK13927 813013882 MreB and similar proteins; Region: MreB_like; cd10225 813013883 nucleotide binding site [chemical binding]; other site 813013884 Mg binding site [ion binding]; other site 813013885 putative protofilament interaction site [polypeptide binding]; other site 813013886 RodZ interaction site [polypeptide binding]; other site 813013887 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 813013888 active site 813013889 substrate-binding site [chemical binding]; other site 813013890 metal-binding site [ion binding] 813013891 GTP binding site [chemical binding]; other site 813013892 Effector from type III secretion system; Region: Effector_1; pfam04518 813013893 Effector from type III secretion system; Region: Effector_1; pfam04518 813013894 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 813013895 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 813013896 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 813013897 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 813013898 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 813013899 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 813013900 active site 813013901 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 813013902 type III secretion system ATPase; Validated; Region: PRK05922 813013903 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813013904 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 813013905 Walker A motif; other site 813013906 ATP binding site [chemical binding]; other site 813013907 Walker B motif; other site 813013908 type III secretion system protein; Validated; Region: PRK05934 813013909 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 813013910 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 813013911 active site 813013912 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 813013913 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 813013914 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813013915 catalytic residue [active] 813013916 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 813013917 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813013918 RNA binding surface [nucleotide binding]; other site 813013919 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 813013920 active site 813013921 biotin--protein ligase; Provisional; Region: PRK05935 813013922 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 813013923 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 813013924 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 813013925 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 813013926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 813013927 motif II; other site 813013928 CCC1-related protein family; Region: CCC1_like_1; cd02437 813013929 seryl-tRNA synthetase; Provisional; Region: PRK05431 813013930 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 813013931 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 813013932 dimer interface [polypeptide binding]; other site 813013933 active site 813013934 motif 1; other site 813013935 motif 2; other site 813013936 motif 3; other site 813013937 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 813013938 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 813013939 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 813013940 dimerization interface [polypeptide binding]; other site 813013941 active site 813013942 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 813013943 homopentamer interface [polypeptide binding]; other site 813013944 active site 813013945 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 813013946 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 813013947 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 813013948 substrate binding site [chemical binding]; other site 813013949 Proteins containing SET domain [General function prediction only]; Region: COG2940 813013950 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 813013951 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 813013952 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 813013953 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 813013954 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 813013955 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 813013956 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 813013957 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 813013958 catalytic loop [active] 813013959 iron binding site [ion binding]; other site 813013960 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 813013961 FAD binding pocket [chemical binding]; other site 813013962 FAD binding motif [chemical binding]; other site 813013963 phosphate binding motif [ion binding]; other site 813013964 beta-alpha-beta structure motif; other site 813013965 NAD binding pocket [chemical binding]; other site 813013966 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 813013967 Histone H1-like protein Hc1; Region: Hc1; pfam07432 813013968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813013969 binding surface 813013970 TPR motif; other site 813013971 Tetratricopeptide repeat; Region: TPR_12; pfam13424 813013972 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 813013973 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 813013974 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 813013975 HemN C-terminal domain; Region: HemN_C; pfam06969 813013976 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 813013977 substrate binding site [chemical binding]; other site 813013978 active site 813013979 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 813013980 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 813013981 motif 1; other site 813013982 active site 813013983 motif 2; other site 813013984 motif 3; other site 813013985 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 813013986 DHHA1 domain; Region: DHHA1; pfam02272 813013987 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 813013988 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 813013989 TPP-binding site [chemical binding]; other site 813013990 dimer interface [polypeptide binding]; other site 813013991 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 813013992 PYR/PP interface [polypeptide binding]; other site 813013993 dimer interface [polypeptide binding]; other site 813013994 TPP binding site [chemical binding]; other site 813013995 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813013996 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 813013997 elongation factor P; Validated; Region: PRK00529 813013998 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 813013999 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 813014000 RNA binding site [nucleotide binding]; other site 813014001 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 813014002 RNA binding site [nucleotide binding]; other site 813014003 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813014004 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 813014005 putative active site [active] 813014006 putative metal binding site [ion binding]; other site 813014007 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 813014008 active site 813014009 metal binding site [ion binding]; metal-binding site 813014010 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 813014011 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 813014012 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 813014013 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813014014 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813014015 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 813014016 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 813014017 Mg++ binding site [ion binding]; other site 813014018 putative catalytic motif [active] 813014019 putative substrate binding site [chemical binding]; other site 813014020 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 813014021 TrkA-N domain; Region: TrkA_N; pfam02254 813014022 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813014023 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813014024 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 813014025 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813014026 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813014027 cell division protein FtsW; Region: ftsW; TIGR02614 813014028 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 813014029 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 813014030 active site 813014031 homodimer interface [polypeptide binding]; other site 813014032 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 813014033 anti sigma factor interaction site; other site 813014034 regulatory phosphorylation site [posttranslational modification]; other site 813014035 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 813014036 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 813014037 hypothetical protein; Provisional; Region: PRK05927 813014038 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 813014039 FeS/SAM binding site; other site 813014040 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813014041 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 813014042 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 813014043 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 813014044 dimer interface [polypeptide binding]; other site 813014045 active site 813014046 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 813014047 active site 813014048 Ap4A binding cleft/pocket [chemical binding]; other site 813014049 P4 phosphate binding site; other site 813014050 nudix motif; other site 813014051 putative P2/P3 phosphate binding site [ion binding]; other site 813014052 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 813014053 dimer interface [polypeptide binding]; other site 813014054 substrate binding site [chemical binding]; other site 813014055 metal binding sites [ion binding]; metal-binding site 813014056 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 813014057 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 813014058 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 813014059 NAD binding site [chemical binding]; other site 813014060 Phe binding site; other site 813014061 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 813014062 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 813014063 active site 813014064 putative lithium-binding site [ion binding]; other site 813014065 substrate binding site [chemical binding]; other site 813014066 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 813014067 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 813014068 putative acyl-acceptor binding pocket; other site 813014069 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 813014070 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 813014071 acyl-activating enzyme (AAE) consensus motif; other site 813014072 AMP binding site [chemical binding]; other site 813014073 active site 813014074 CoA binding site [chemical binding]; other site 813014075 8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937 813014076 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 813014077 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813014078 catalytic residue [active] 813014079 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 813014080 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813014081 ATP binding site [chemical binding]; other site 813014082 putative Mg++ binding site [ion binding]; other site 813014083 helicase superfamily c-terminal domain; Region: HELICc; smart00490 813014084 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 813014085 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813014086 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 813014087 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 813014088 dimer interface [polypeptide binding]; other site 813014089 putative anticodon binding site; other site 813014090 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813014091 motif 1; other site 813014092 dimer interface [polypeptide binding]; other site 813014093 active site 813014094 motif 2; other site 813014095 motif 3; other site 813014096 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 813014097 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 813014098 active site 813014099 HIGH motif; other site 813014100 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 813014101 KMSKS motif; other site 813014102 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813014103 tRNA binding surface [nucleotide binding]; other site 813014104 anticodon binding site; other site 813014105 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 813014106 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813014107 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 813014108 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 813014109 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 813014110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 813014111 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 813014112 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 813014113 GIY-YIG motif/motif A; other site 813014114 active site 813014115 catalytic site [active] 813014116 putative DNA binding site [nucleotide binding]; other site 813014117 metal binding site [ion binding]; metal-binding site 813014118 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 813014119 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 813014120 MutS domain I; Region: MutS_I; pfam01624 813014121 MutS domain II; Region: MutS_II; pfam05188 813014122 MutS domain III; Region: MutS_III; pfam05192 813014123 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 813014124 Walker A/P-loop; other site 813014125 ATP binding site [chemical binding]; other site 813014126 Q-loop/lid; other site 813014127 ABC transporter signature motif; other site 813014128 Walker B; other site 813014129 D-loop; other site 813014130 H-loop/switch region; other site 813014131 DNA primase; Validated; Region: dnaG; PRK05667 813014132 CHC2 zinc finger; Region: zf-CHC2; pfam01807 813014133 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 813014134 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 813014135 active site 813014136 metal binding site [ion binding]; metal-binding site 813014137 interdomain interaction site; other site 813014138 glycyl-tRNA synthetase; Provisional; Region: PRK14908 813014139 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 813014140 dimer interface [polypeptide binding]; other site 813014141 motif 1; other site 813014142 active site 813014143 motif 2; other site 813014144 motif 3; other site 813014145 DALR anticodon binding domain; Region: DALR_1; pfam05746 813014146 glycogen synthase; Provisional; Region: glgA; PRK00654 813014147 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 813014148 ADP-binding pocket [chemical binding]; other site 813014149 homodimer interface [polypeptide binding]; other site 813014150 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 813014151 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 813014152 5S rRNA interface [nucleotide binding]; other site 813014153 CTC domain interface [polypeptide binding]; other site 813014154 L16 interface [polypeptide binding]; other site 813014155 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 813014156 putative active site [active] 813014157 catalytic residue [active] 813014158 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 813014159 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 813014160 Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359 813014161 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 813014162 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 813014163 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 813014164 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 813014165 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 813014166 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813014167 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813014168 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 813014169 putative acyl-acceptor binding pocket; other site 813014170 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 813014171 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 813014172 homodimer interface [polypeptide binding]; other site 813014173 oligonucleotide binding site [chemical binding]; other site 813014174 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 813014175 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 813014176 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813014177 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813014178 YtxH-like protein; Region: YtxH; cl02079 813014179 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 813014180 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 813014181 active site 813014182 substrate binding site [chemical binding]; other site 813014183 metal binding site [ion binding]; metal-binding site 813014184 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 813014185 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 813014186 glutaminase active site [active] 813014187 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 813014188 dimer interface [polypeptide binding]; other site 813014189 active site 813014190 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 813014191 dimer interface [polypeptide binding]; other site 813014192 active site 813014193 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 813014194 aromatic amino acid transport protein; Region: araaP; TIGR00837 813014195 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 813014196 aromatic amino acid transport protein; Region: araaP; TIGR00837 813014197 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 813014198 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 813014199 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 813014200 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 813014201 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 813014202 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 813014203 CoA-ligase; Region: Ligase_CoA; pfam00549 813014204 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 813014205 CoA binding domain; Region: CoA_binding; smart00881 813014206 CoA-ligase; Region: Ligase_CoA; pfam00549 813014207 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 813014208 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 813014209 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 813014210 protein binding site [polypeptide binding]; other site 813014211 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 813014212 protein binding site [polypeptide binding]; other site 813014213 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 813014214 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 813014215 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813014216 Peptidase M16C associated; Region: M16C_assoc; pfam08367 813014217 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813014218 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 813014219 RmuC family; Region: RmuC; pfam02646 813014220 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 813014221 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 813014222 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 813014223 ATP cone domain; Region: ATP-cone; pfam03477 813014224 ATP cone domain; Region: ATP-cone; pfam03477 813014225 Class I ribonucleotide reductase; Region: RNR_I; cd01679 813014226 active site 813014227 dimer interface [polypeptide binding]; other site 813014228 catalytic residues [active] 813014229 effector binding site; other site 813014230 R2 peptide binding site; other site 813014231 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 813014232 dimer interface [polypeptide binding]; other site 813014233 putative radical transfer pathway; other site 813014234 diiron center [ion binding]; other site 813014235 tyrosyl radical; other site 813014236 Putative methyltransferase; Region: Methyltransf_4; pfam02390 813014237 Methyltransferase domain; Region: Methyltransf_18; pfam12847 813014238 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 813014239 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 813014240 FAD binding domain; Region: FAD_binding_4; pfam01565 813014241 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 813014242 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 813014243 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 813014244 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 813014245 Ribosomal protein L35 [Translation, ribosomal structure and biogenesis]; Region: RpmI; COG0291 813014246 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 813014247 23S rRNA binding site [nucleotide binding]; other site 813014248 L21 binding site [polypeptide binding]; other site 813014249 L13 binding site [polypeptide binding]; other site 813014250 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 813014251 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 813014252 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 813014253 motif 1; other site 813014254 dimer interface [polypeptide binding]; other site 813014255 active site 813014256 motif 2; other site 813014257 motif 3; other site 813014258 Predicted permeases [General function prediction only]; Region: COG0795 813014259 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 813014260 Predicted permeases [General function prediction only]; Region: COG0795 813014261 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 813014262 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 813014263 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 813014264 Ligand Binding Site [chemical binding]; other site 813014265 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 813014266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813014267 Walker A motif; other site 813014268 ATP binding site [chemical binding]; other site 813014269 Walker B motif; other site 813014270 arginine finger; other site 813014271 Peptidase family M41; Region: Peptidase_M41; pfam01434 813014272 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 813014273 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 813014274 RNase E interface [polypeptide binding]; other site 813014275 trimer interface [polypeptide binding]; other site 813014276 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 813014277 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 813014278 RNase E interface [polypeptide binding]; other site 813014279 trimer interface [polypeptide binding]; other site 813014280 active site 813014281 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 813014282 putative nucleic acid binding region [nucleotide binding]; other site 813014283 G-X-X-G motif; other site 813014284 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 813014285 RNA binding site [nucleotide binding]; other site 813014286 domain interface; other site 813014287 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 813014288 16S/18S rRNA binding site [nucleotide binding]; other site 813014289 S13e-L30e interaction site [polypeptide binding]; other site 813014290 25S rRNA binding site [nucleotide binding]; other site 813014291 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 813014292 nucleoside/Zn binding site; other site 813014293 dimer interface [polypeptide binding]; other site 813014294 catalytic motif [active] 813014295 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813014296 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813014297 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813014298 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813014299 methionine aminopeptidase; Provisional; Region: PRK12318 813014300 SEC-C motif; Region: SEC-C; pfam02810 813014301 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 813014302 active site 813014303 MarC family integral membrane protein; Region: MarC; pfam01914 813014304 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 813014305 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 813014306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813014307 dimer interface [polypeptide binding]; other site 813014308 conserved gate region; other site 813014309 putative PBP binding loops; other site 813014310 ABC-ATPase subunit interface; other site 813014311 NMT1/THI5 like; Region: NMT1; pfam09084 813014312 fumarate hydratase, class II; Region: fumC_II; TIGR00979 813014313 Class II fumarases; Region: Fumarase_classII; cd01362 813014314 active site 813014315 tetramer interface [polypeptide binding]; other site 813014316 high affinity sulphate transporter 1; Region: sulP; TIGR00815 813014317 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 813014318 Sulfate transporter family; Region: Sulfate_transp; pfam00916 813014319 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 813014320 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 813014321 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 813014322 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 813014323 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 813014324 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 813014325 active site triad [active] 813014326 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 813014327 LytB protein; Region: LYTB; pfam02401 813014328 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 813014329 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 813014330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 813014331 binding surface 813014332 TPR motif; other site 813014333 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 813014334 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 813014335 active site 813014336 DNA binding site [nucleotide binding] 813014337 Int/Topo IB signature motif; other site 813014338 glycogen branching enzyme; Provisional; Region: PRK05402 813014339 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 813014340 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 813014341 active site 813014342 catalytic site [active] 813014343 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 813014344 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 813014345 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813014346 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813014347 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813014348 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813014349 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813014350 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813014351 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813014352 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813014353 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813014354 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813014355 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813014356 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813014357 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813014358 Uncharacterized conserved protein [Function unknown]; Region: COG2155 813014359 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 813014360 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 813014361 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 813014362 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 813014363 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 813014364 GatB domain; Region: GatB_Yqey; pfam02637 813014365 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 813014366 ribonuclease HIII; Region: rnhC; TIGR00716 813014367 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 813014368 RNA/DNA hybrid binding site [nucleotide binding]; other site 813014369 active site 813014370 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 813014371 Helix-turn-helix domain; Region: HTH_25; pfam13413 813014372 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906 813014373 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 813014374 putative acyl-acceptor binding pocket; other site 813014375 Uncharacterized conserved protein [Function unknown]; Region: COG1624 813014376 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 813014377 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 813014378 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 813014379 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 813014380 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 813014381 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 813014382 putative active site [active] 813014383 PhoH-like protein; Region: PhoH; pfam02562 813014384 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 813014385 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 813014386 Catalytic site [active] 813014387 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 813014388 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 813014389 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 813014390 peptide chain release factor 1; Validated; Region: prfA; PRK00591 813014391 PCRF domain; Region: PCRF; pfam03462 813014392 RF-1 domain; Region: RF-1; pfam00472 813014393 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 813014394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813014395 S-adenosylmethionine binding site [chemical binding]; other site 813014396 signal recognition particle protein; Provisional; Region: PRK10867 813014397 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 813014398 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 813014399 P loop; other site 813014400 GTP binding site [chemical binding]; other site 813014401 Signal peptide binding domain; Region: SRP_SPB; pfam02978 813014402 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 813014403 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 813014404 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 813014405 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 813014406 RNA/DNA hybrid binding site [nucleotide binding]; other site 813014407 active site 813014408 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 813014409 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 813014410 catalytic site [active] 813014411 G-X2-G-X-G-K; other site 813014412 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 813014413 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 813014414 active site 813014415 HIGH motif; other site 813014416 KMSKS motif; other site 813014417 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 813014418 tRNA binding surface [nucleotide binding]; other site 813014419 anticodon binding site; other site 813014420 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 813014421 AAA domain; Region: AAA_30; pfam13604 813014422 Family description; Region: UvrD_C_2; pfam13538 813014423 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 813014424 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 813014425 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 813014426 conserved cys residue [active] 813014427 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 813014428 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 813014429 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 813014430 trimer interface [polypeptide binding]; other site 813014431 active site 813014432 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 813014433 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813014434 Walker A motif; other site 813014435 ATP binding site [chemical binding]; other site 813014436 Walker B motif; other site 813014437 arginine finger; other site 813014438 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 813014439 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813014440 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 813014441 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 813014442 dimer interface [polypeptide binding]; other site 813014443 ssDNA binding site [nucleotide binding]; other site 813014444 tetramer (dimer of dimers) interface [polypeptide binding]; other site 813014445 multifunctional aminopeptidase A; Provisional; Region: PRK00913 813014446 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 813014447 interface (dimer of trimers) [polypeptide binding]; other site 813014448 Substrate-binding/catalytic site; other site 813014449 Zn-binding sites [ion binding]; other site 813014450 hypothetical protein; Provisional; Region: PRK05907 813014451 Predicted methyltransferases [General function prediction only]; Region: COG0313 813014452 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 813014453 putative SAM binding site [chemical binding]; other site 813014454 homodimer interface [polypeptide binding]; other site 813014455 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 813014456 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813014457 FeS/SAM binding site; other site 813014458 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 813014459 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 813014460 TPP-binding site [chemical binding]; other site 813014461 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 813014462 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 813014463 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813014464 E3 interaction surface; other site 813014465 lipoyl attachment site [posttranslational modification]; other site 813014466 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813014467 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 813014468 1-hydroxy-2-methyl-2-(e)-butenyl 4-diphosphate synthase [Lipid metabolism]; Region: gcpE; COG0821 813014469 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 813014470 ADP-ribose binding site [chemical binding]; other site 813014471 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 813014472 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 813014473 catalytic loop [active] 813014474 iron binding site [ion binding]; other site 813014475 type III secretion system protein; Validated; Region: PRK05910 813014476 FHIPEP family; Region: FHIPEP; pfam00771 813014477 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 813014478 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 813014479 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 813014480 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 813014481 DNA binding residues [nucleotide binding] 813014482 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 813014483 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 813014484 active site 813014485 HIGH motif; other site 813014486 dimer interface [polypeptide binding]; other site 813014487 KMSKS motif; other site 813014488 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813014489 RNA binding surface [nucleotide binding]; other site 813014490 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 813014491 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 813014492 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 813014493 GTP-binding protein LepA; Provisional; Region: PRK05433 813014494 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 813014495 G1 box; other site 813014496 putative GEF interaction site [polypeptide binding]; other site 813014497 GTP/Mg2+ binding site [chemical binding]; other site 813014498 Switch I region; other site 813014499 G2 box; other site 813014500 G3 box; other site 813014501 Switch II region; other site 813014502 G4 box; other site 813014503 G5 box; other site 813014504 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 813014505 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 813014506 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 813014507 ADP/ATP carrier protein family; Region: AAA; TIGR00769 813014508 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 813014509 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 813014510 intersubunit interface [polypeptide binding]; other site 813014511 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 813014512 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 813014513 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813014514 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813014515 ABC-ATPase subunit interface; other site 813014516 dimer interface [polypeptide binding]; other site 813014517 putative PBP binding regions; other site 813014518 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 813014519 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 813014520 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813014521 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813014522 ABC-ATPase subunit interface; other site 813014523 dimer interface [polypeptide binding]; other site 813014524 putative PBP binding regions; other site 813014525 recF protein; Region: recf; TIGR00611 813014526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813014527 Walker A/P-loop; other site 813014528 ATP binding site [chemical binding]; other site 813014529 Q-loop/lid; other site 813014530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813014531 ABC transporter signature motif; other site 813014532 Walker B; other site 813014533 DNA polymerase III subunit beta; Validated; Region: PRK05643 813014534 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 813014535 putative DNA binding surface [nucleotide binding]; other site 813014536 dimer interface [polypeptide binding]; other site 813014537 beta-clamp/clamp loader binding surface; other site 813014538 beta-clamp/translesion DNA polymerase binding surface; other site 813014539 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 813014540 SmpB-tmRNA interface; other site 813014541 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 813014542 ApbE family; Region: ApbE; pfam02424 813014543 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813014544 PLD-like domain; Region: PLDc_2; pfam13091 813014545 putative active site [active] 813014546 catalytic site [active] 813014547 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813014548 PLD-like domain; Region: PLDc_2; pfam13091 813014549 putative active site [active] 813014550 catalytic site [active] 813014551 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 813014552 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813014553 HrpJ-like domain; Region: HrpJ; cl15454 813014554 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 813014555 FHIPEP family; Region: FHIPEP; pfam00771 813014556 type III secretion system protein; Validated; Region: PRK06298 813014557 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 813014558 GTP-binding protein YchF; Reviewed; Region: PRK09601 813014559 YchF GTPase; Region: YchF; cd01900 813014560 G1 box; other site 813014561 GTP/Mg2+ binding site [chemical binding]; other site 813014562 Switch I region; other site 813014563 G2 box; other site 813014564 Switch II region; other site 813014565 G3 box; other site 813014566 G4 box; other site 813014567 G5 box; other site 813014568 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 813014569 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 813014570 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 813014571 active site 813014572 Riboflavin kinase; Region: Flavokinase; smart00904 813014573 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 813014574 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 813014575 RNA binding site [nucleotide binding]; other site 813014576 active site 813014577 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 813014578 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 813014579 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 813014580 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 813014581 G1 box; other site 813014582 putative GEF interaction site [polypeptide binding]; other site 813014583 GTP/Mg2+ binding site [chemical binding]; other site 813014584 Switch I region; other site 813014585 G2 box; other site 813014586 G3 box; other site 813014587 Switch II region; other site 813014588 G4 box; other site 813014589 G5 box; other site 813014590 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 813014591 Translation-initiation factor 2; Region: IF-2; pfam11987 813014592 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 813014593 transcription termination factor NusA; Region: NusA; TIGR01953 813014594 NusA N-terminal domain; Region: NusA_N; pfam08529 813014595 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 813014596 RNA binding site [nucleotide binding]; other site 813014597 homodimer interface [polypeptide binding]; other site 813014598 NusA-like KH domain; Region: KH_5; pfam13184 813014599 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 813014600 G-X-X-G motif; other site 813014601 ribosomal protein S1; Region: rpsA; TIGR00717 813014602 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 813014603 RNA binding site [nucleotide binding]; other site 813014604 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 813014605 RNA binding site [nucleotide binding]; other site 813014606 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813014607 RNA binding site [nucleotide binding]; other site 813014608 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813014609 RNA binding site [nucleotide binding]; other site 813014610 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 813014611 RNA binding site [nucleotide binding]; other site 813014612 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 813014613 RNA binding site [nucleotide binding]; other site 813014614 domain interface; other site 813014615 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 813014616 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 813014617 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 813014618 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 813014619 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 813014620 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 813014621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 813014622 active site 813014623 motif I; other site 813014624 motif II; other site 813014625 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 813014626 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 813014627 NAD binding site [chemical binding]; other site 813014628 homotetramer interface [polypeptide binding]; other site 813014629 homodimer interface [polypeptide binding]; other site 813014630 substrate binding site [chemical binding]; other site 813014631 active site 813014632 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 813014633 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813014634 RNA binding surface [nucleotide binding]; other site 813014635 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 813014636 active site 813014637 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 813014638 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 813014639 minor groove reading motif; other site 813014640 helix-hairpin-helix signature motif; other site 813014641 substrate binding pocket [chemical binding]; other site 813014642 active site 813014643 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 813014644 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 813014645 DNA binding and oxoG recognition site [nucleotide binding] 813014646 Uncharacterized conserved protein [Function unknown]; Region: COG0327 813014647 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 813014648 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 813014649 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 813014650 ring oligomerisation interface [polypeptide binding]; other site 813014651 ATP/Mg binding site [chemical binding]; other site 813014652 stacking interactions; other site 813014653 hinge regions; other site 813014654 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 813014655 oligomerisation interface [polypeptide binding]; other site 813014656 mobile loop; other site 813014657 roof hairpin; other site 813014658 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 813014659 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 813014660 active site 813014661 Zn binding site [ion binding]; other site 813014662 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 813014663 Clp amino terminal domain; Region: Clp_N; pfam02861 813014664 Clp amino terminal domain; Region: Clp_N; pfam02861 813014665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813014666 Walker A motif; other site 813014667 ATP binding site [chemical binding]; other site 813014668 Walker B motif; other site 813014669 arginine finger; other site 813014670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813014671 Walker A motif; other site 813014672 ATP binding site [chemical binding]; other site 813014673 Walker B motif; other site 813014674 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 813014675 Uncharacterized conserved protein [Function unknown]; Region: COG2912 813014676 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 813014677 IncA protein; Region: IncA; pfam04156 813014678 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 813014679 elongation factor P; Provisional; Region: PRK12426 813014680 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813014681 RNA binding site [nucleotide binding]; other site 813014682 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 813014683 RNA binding site [nucleotide binding]; other site 813014684 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 813014685 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 813014686 carboxyltransferase (CT) interaction site; other site 813014687 biotinylation site [posttranslational modification]; other site 813014688 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 813014689 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 813014690 ATP-grasp domain; Region: ATP-grasp_4; cl17255 813014691 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 813014692 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 813014693 23S rRNA interface [nucleotide binding]; other site 813014694 L3 interface [polypeptide binding]; other site 813014695 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 813014696 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 813014697 NlpC/P60 family; Region: NLPC_P60; cl17555 813014698 adenylate kinase; Reviewed; Region: adk; PRK00279 813014699 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 813014700 AMP-binding site [chemical binding]; other site 813014701 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 813014702 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 813014703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813014704 dimer interface [polypeptide binding]; other site 813014705 conserved gate region; other site 813014706 putative PBP binding loops; other site 813014707 ABC-ATPase subunit interface; other site 813014708 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 813014709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813014710 Walker A/P-loop; other site 813014711 ATP binding site [chemical binding]; other site 813014712 Q-loop/lid; other site 813014713 ABC transporter signature motif; other site 813014714 Walker B; other site 813014715 D-loop; other site 813014716 H-loop/switch region; other site 813014717 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 813014718 Methyltransferase domain; Region: Methyltransf_23; pfam13489 813014719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813014720 S-adenosylmethionine binding site [chemical binding]; other site 813014721 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 813014722 Serine hydrolase (FSH1); Region: FSH1; pfam03959 813014723 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 813014724 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 813014725 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 813014726 active site 813014727 conserved hypothetical integral membrane protein; Region: TIGR00697 813014728 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 813014729 SEC-C motif; Region: SEC-C; pfam02810 813014730 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 813014731 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813014732 active site 813014733 ATP binding site [chemical binding]; other site 813014734 substrate binding site [chemical binding]; other site 813014735 activation loop (A-loop); other site 813014736 Uncharacterized conserved protein [Function unknown]; Region: COG1262 813014737 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 813014738 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 813014739 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 813014740 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 813014741 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 813014742 FtsX-like permease family; Region: FtsX; pfam02687 813014743 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 813014744 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 813014745 Walker A/P-loop; other site 813014746 ATP binding site [chemical binding]; other site 813014747 Q-loop/lid; other site 813014748 ABC transporter signature motif; other site 813014749 Walker B; other site 813014750 D-loop; other site 813014751 H-loop/switch region; other site 813014752 membrane-attack complex / perforin; Region: MACPF; smart00457 813014753 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 813014754 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813014755 PLD-like domain; Region: PLDc_2; pfam13091 813014756 putative active site [active] 813014757 catalytic site [active] 813014758 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813014759 PLD-like domain; Region: PLDc_2; pfam13091 813014760 putative active site [active] 813014761 catalytic site [active] 813014762 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813014763 PLD-like domain; Region: PLDc_2; pfam13091 813014764 putative active site [active] 813014765 catalytic site [active] 813014766 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813014767 PLD-like domain; Region: PLDc_2; pfam13091 813014768 putative active site [active] 813014769 catalytic site [active] 813014770 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813014771 PLD-like domain; Region: PLDc_2; pfam13091 813014772 putative active site [active] 813014773 catalytic site [active] 813014774 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813014775 PLD-like domain; Region: PLDc_2; pfam13091 813014776 putative active site [active] 813014777 catalytic site [active] 813014778 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813014779 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 813014780 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 813014781 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 813014782 trp operon repressor, proteobacterial; Region: TrpR; TIGR01321 813014783 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 813014784 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 813014785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813014786 catalytic residue [active] 813014787 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 813014788 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 813014789 substrate binding site [chemical binding]; other site 813014790 active site 813014791 catalytic residues [active] 813014792 heterodimer interface [polypeptide binding]; other site 813014793 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 813014794 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 813014795 peptide binding site [polypeptide binding]; other site 813014796 putative disulfide oxidoreductase; Provisional; Region: PRK00611 813014797 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 813014798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813014799 Walker A/P-loop; other site 813014800 ATP binding site [chemical binding]; other site 813014801 Q-loop/lid; other site 813014802 ABC transporter signature motif; other site 813014803 Walker B; other site 813014804 D-loop; other site 813014805 H-loop/switch region; other site 813014806 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 813014807 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 813014808 Ligand binding site; other site 813014809 oligomer interface; other site 813014810 CTP synthetase; Validated; Region: pyrG; PRK05380 813014811 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 813014812 Catalytic site [active] 813014813 active site 813014814 UTP binding site [chemical binding]; other site 813014815 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 813014816 active site 813014817 putative oxyanion hole; other site 813014818 catalytic triad [active] 813014819 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 813014820 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 813014821 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 813014822 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 813014823 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 813014824 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 813014825 putative active site [active] 813014826 DNA polymerase III subunit delta'; Validated; Region: PRK05917 813014827 DNA polymerase III subunit delta'; Validated; Region: PRK08485 813014828 thymidylate kinase; Validated; Region: tmk; PRK00698 813014829 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 813014830 TMP-binding site; other site 813014831 ATP-binding site [chemical binding]; other site 813014832 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 813014833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813014834 ATP binding site [chemical binding]; other site 813014835 Mg2+ binding site [ion binding]; other site 813014836 G-X-G motif; other site 813014837 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 813014838 anchoring element; other site 813014839 dimer interface [polypeptide binding]; other site 813014840 ATP binding site [chemical binding]; other site 813014841 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 813014842 active site 813014843 putative metal-binding site [ion binding]; other site 813014844 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 813014845 Protein of unknown function (DUF721); Region: DUF721; pfam05258 813014846 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 813014847 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 813014848 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 813014849 MgtE intracellular N domain; Region: MgtE_N; pfam03448 813014850 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 813014851 Divalent cation transporter; Region: MgtE; pfam01769 813014852 UGMP family protein; Validated; Region: PRK09604 813014853 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 813014854 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 813014855 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 813014856 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 813014857 peptide binding site [polypeptide binding]; other site 813014858 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 813014859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813014860 dimer interface [polypeptide binding]; other site 813014861 conserved gate region; other site 813014862 putative PBP binding loops; other site 813014863 ABC-ATPase subunit interface; other site 813014864 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 813014865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813014866 dimer interface [polypeptide binding]; other site 813014867 conserved gate region; other site 813014868 putative PBP binding loops; other site 813014869 ABC-ATPase subunit interface; other site 813014870 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813014871 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 813014872 Walker A/P-loop; other site 813014873 ATP binding site [chemical binding]; other site 813014874 Q-loop/lid; other site 813014875 ABC transporter signature motif; other site 813014876 Walker B; other site 813014877 D-loop; other site 813014878 H-loop/switch region; other site 813014879 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 813014880 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 813014881 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813014882 Walker A/P-loop; other site 813014883 ATP binding site [chemical binding]; other site 813014884 Q-loop/lid; other site 813014885 ABC transporter signature motif; other site 813014886 Walker B; other site 813014887 D-loop; other site 813014888 H-loop/switch region; other site 813014889 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813014890 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 813014891 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 813014892 transmembrane helices; other site 813014893 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 813014894 active site 813014895 ADP/pyrophosphate binding site [chemical binding]; other site 813014896 dimerization interface [polypeptide binding]; other site 813014897 allosteric effector site; other site 813014898 fructose-1,6-bisphosphate binding site; other site 813014899 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 813014900 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 813014901 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 813014902 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 813014903 active site 813014904 ADP/pyrophosphate binding site [chemical binding]; other site 813014905 dimerization interface [polypeptide binding]; other site 813014906 allosteric effector site; other site 813014907 fructose-1,6-bisphosphate binding site; other site 813014908 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 813014909 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 813014910 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 813014911 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 813014912 HIGH motif; other site 813014913 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 813014914 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 813014915 active site 813014916 KMSKS motif; other site 813014917 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 813014918 tRNA binding surface [nucleotide binding]; other site 813014919 Putative transcriptional regulator [Transcription]; Region: COG1678 813014920 Uncharacterized conserved protein [Function unknown]; Region: COG1259 813014921 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 813014922 tetramer (dimer of dimers) interface [polypeptide binding]; other site 813014923 active site 813014924 dimer interface [polypeptide binding]; other site 813014925 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 813014926 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 813014927 putative active site; other site 813014928 catalytic residue [active] 813014929 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 813014930 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 813014931 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 813014932 Ligand Binding Site [chemical binding]; other site 813014933 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 813014934 prenyltransferase; Reviewed; Region: ubiA; PRK12876 813014935 UbiA prenyltransferase family; Region: UbiA; pfam01040 813014936 aromatic acid decarboxylase; Validated; Region: PRK05920 813014937 Flavoprotein; Region: Flavoprotein; pfam02441 813014938 Uncharacterized conserved protein [Function unknown]; Region: COG1284 813014939 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 813014940 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813014941 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 813014942 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 813014943 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 813014944 Na2 binding site [ion binding]; other site 813014945 putative substrate binding site 1 [chemical binding]; other site 813014946 Na binding site 1 [ion binding]; other site 813014947 putative substrate binding site 2 [chemical binding]; other site 813014948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813014949 putative substrate translocation pore; other site 813014950 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 813014951 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 813014952 ligand binding site [chemical binding]; other site 813014953 flexible hinge region; other site 813014954 acyl carrier protein; Provisional; Region: acpP; PRK00982 813014955 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 813014956 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 813014957 NAD(P) binding site [chemical binding]; other site 813014958 homotetramer interface [polypeptide binding]; other site 813014959 homodimer interface [polypeptide binding]; other site 813014960 active site 813014961 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 813014962 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 813014963 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 813014964 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 813014965 dimer interface [polypeptide binding]; other site 813014966 active site 813014967 CoA binding pocket [chemical binding]; other site 813014968 recombination protein RecR; Region: recR; TIGR00615 813014969 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 813014970 putative active site [active] 813014971 putative metal-binding site [ion binding]; other site 813014972 tetramer interface [polypeptide binding]; other site 813014973 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 813014974 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813014975 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813014976 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813014977 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813014978 Surface antigen; Region: Bac_surface_Ag; pfam01103 813014979 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 813014980 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 813014981 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 813014982 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 813014983 trimer interface [polypeptide binding]; other site 813014984 active site 813014985 UDP-GlcNAc binding site [chemical binding]; other site 813014986 lipid binding site [chemical binding]; lipid-binding site 813014987 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 813014988 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 813014989 tetramer interface [polypeptide binding]; other site 813014990 TPP-binding site [chemical binding]; other site 813014991 heterodimer interface [polypeptide binding]; other site 813014992 phosphorylation loop region [posttranslational modification] 813014993 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 813014994 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 813014995 alpha subunit interface [polypeptide binding]; other site 813014996 TPP binding site [chemical binding]; other site 813014997 heterodimer interface [polypeptide binding]; other site 813014998 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813014999 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 813015000 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813015001 E3 interaction surface; other site 813015002 lipoyl attachment site [posttranslational modification]; other site 813015003 e3 binding domain; Region: E3_binding; pfam02817 813015004 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813015005 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 813015006 homodimer interface [polypeptide binding]; other site 813015007 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 813015008 active site pocket [active] 813015009 chromosomal replication initiation protein; Provisional; Region: PRK12422 813015010 DnaA N-terminal domain; Region: DnaA_N; pfam11638 813015011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813015012 Walker A motif; other site 813015013 ATP binding site [chemical binding]; other site 813015014 Walker B motif; other site 813015015 arginine finger; other site 813015016 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 813015017 DnaA box-binding interface [nucleotide binding]; other site 813015018 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 813015019 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 813015020 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 813015021 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 813015022 homodimer interface [polypeptide binding]; other site 813015023 metal binding site [ion binding]; metal-binding site 813015024 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 813015025 Domain of unknown function DUF21; Region: DUF21; pfam01595 813015026 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813015027 Transporter associated domain; Region: CorC_HlyC; smart01091 813015028 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 813015029 Domain of unknown function DUF21; Region: DUF21; pfam01595 813015030 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813015031 Transporter associated domain; Region: CorC_HlyC; smart01091 813015032 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 813015033 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 813015034 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813015035 catalytic residue [active] 813015036 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 813015037 Protein phosphatase 2C; Region: PP2C; pfam00481 813015038 active site 813015039 Uncharacterized conserved protein [Function unknown]; Region: COG5465 813015040 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 813015041 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 813015042 active site 813015043 catalytic site [active] 813015044 substrate binding site [chemical binding]; other site 813015045 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 813015046 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 813015047 nucleosidase; Provisional; Region: PRK05634 813015048 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 813015049 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 813015050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813015051 Walker A/P-loop; other site 813015052 ATP binding site [chemical binding]; other site 813015053 Q-loop/lid; other site 813015054 ABC transporter signature motif; other site 813015055 Walker B; other site 813015056 D-loop; other site 813015057 H-loop/switch region; other site 813015058 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 813015059 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 813015060 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 813015061 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 813015062 active site 813015063 metal binding site [ion binding]; metal-binding site 813015064 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 813015065 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 813015066 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813015067 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813015068 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 813015069 MraW methylase family; Region: Methyltransf_5; pfam01795 813015070 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813015071 TPR motif; other site 813015072 binding surface 813015073 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 813015074 DnaA N-terminal domain; Region: DnaA_N; pfam11638 813015075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813015076 Walker A motif; other site 813015077 ATP binding site [chemical binding]; other site 813015078 Walker B motif; other site 813015079 arginine finger; other site 813015080 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 813015081 DnaA box-binding interface [nucleotide binding]; other site 813015082 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 813015083 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 813015084 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 813015085 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 813015086 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 813015087 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 813015088 lipoyl attachment site [posttranslational modification]; other site 813015089 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 813015090 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 813015091 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813015092 putative active site [active] 813015093 catalytic site [active] 813015094 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813015095 putative active site [active] 813015096 catalytic site [active] 813015097 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 813015098 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 813015099 Clp amino terminal domain; Region: Clp_N; pfam02861 813015100 Clp amino terminal domain; Region: Clp_N; pfam02861 813015101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813015102 Walker A motif; other site 813015103 ATP binding site [chemical binding]; other site 813015104 Walker B motif; other site 813015105 arginine finger; other site 813015106 UvrB/uvrC motif; Region: UVR; pfam02151 813015107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813015108 Walker A motif; other site 813015109 ATP binding site [chemical binding]; other site 813015110 Walker B motif; other site 813015111 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 813015112 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 813015113 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 813015114 Ligand Binding Site [chemical binding]; other site 813015115 Helix-turn-helix domain; Region: HTH_17; pfam12728 813015116 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 813015117 active site 813015118 phosphorylation site [posttranslational modification] 813015119 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 813015120 active site 813015121 phosphorylation site [posttranslational modification] 813015122 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 813015123 trimer interface [polypeptide binding]; other site 813015124 active site 813015125 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 813015126 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 813015127 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 813015128 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 813015129 active site 813015130 substrate binding site [chemical binding]; other site 813015131 metal binding site [ion binding]; metal-binding site 813015132 ribonuclease III; Reviewed; Region: rnc; PRK00102 813015133 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 813015134 dimerization interface [polypeptide binding]; other site 813015135 active site 813015136 metal binding site [ion binding]; metal-binding site 813015137 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 813015138 dsRNA binding site [nucleotide binding]; other site 813015139 DNA repair protein RadA; Provisional; Region: PRK11823 813015140 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 813015141 Walker A motif/ATP binding site; other site 813015142 ATP binding site [chemical binding]; other site 813015143 Walker B motif; other site 813015144 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 813015145 porphobilinogen deaminase; Provisional; Region: PRK01066 813015146 Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379 813015147 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 813015148 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 813015149 HIGH motif; other site 813015150 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 813015151 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 813015152 active site 813015153 KMSKS motif; other site 813015154 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 813015155 tRNA binding surface [nucleotide binding]; other site 813015156 anticodon binding site; other site 813015157 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 813015158 V-type ATP synthase subunit K; Provisional; Region: PRK09621 813015159 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 813015160 V-type ATP synthase subunit I; Validated; Region: PRK05771 813015161 Protein of unknown function (DUF1319); Region: DUF1319; pfam07028 813015162 V-type ATP synthase subunit D; Provisional; Region: PRK02195 813015163 V-type ATP synthase subunit B; Provisional; Region: PRK02118 813015164 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813015165 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 813015166 Walker A motif homologous position; other site 813015167 Walker B motif; other site 813015168 V-type ATP synthase subunit A; Provisional; Region: PRK04192 813015169 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813015170 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 813015171 Walker A motif/ATP binding site; other site 813015172 Walker B motif; other site 813015173 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 813015174 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 813015175 V-type ATP synthase subunit E; Provisional; Region: PRK01005 813015176 V-type ATP synthase subunit E; Provisional; Region: PRK01558 813015177 transaldolase-like protein; Provisional; Region: PTZ00411 813015178 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 813015179 active site 813015180 dimer interface [polypeptide binding]; other site 813015181 catalytic residue [active] 813015182 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 813015183 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 813015184 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 813015185 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 813015186 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 813015187 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 813015188 RPB12 interaction site [polypeptide binding]; other site 813015189 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 813015190 RPB3 interaction site [polypeptide binding]; other site 813015191 RPB1 interaction site [polypeptide binding]; other site 813015192 RPB11 interaction site [polypeptide binding]; other site 813015193 RPB10 interaction site [polypeptide binding]; other site 813015194 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 813015195 L11 interface [polypeptide binding]; other site 813015196 putative EF-Tu interaction site [polypeptide binding]; other site 813015197 putative EF-G interaction site [polypeptide binding]; other site 813015198 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 813015199 23S rRNA interface [nucleotide binding]; other site 813015200 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 813015201 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 813015202 mRNA/rRNA interface [nucleotide binding]; other site 813015203 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 813015204 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 813015205 putative thiostrepton binding site; other site 813015206 23S rRNA interface [nucleotide binding]; other site 813015207 L7/L12 interface [polypeptide binding]; other site 813015208 L25 interface [polypeptide binding]; other site 813015209 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 813015210 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 813015211 putative homodimer interface [polypeptide binding]; other site 813015212 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 813015213 heterodimer interface [polypeptide binding]; other site 813015214 homodimer interface [polypeptide binding]; other site 813015215 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 813015216 elongation factor Tu; Reviewed; Region: PRK12735 813015217 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 813015218 G1 box; other site 813015219 GEF interaction site [polypeptide binding]; other site 813015220 GTP/Mg2+ binding site [chemical binding]; other site 813015221 Switch I region; other site 813015222 G2 box; other site 813015223 G3 box; other site 813015224 Switch II region; other site 813015225 G4 box; other site 813015226 G5 box; other site 813015227 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 813015228 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 813015229 Antibiotic Binding Site [chemical binding]; other site 813015230 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 813015231 rRNA binding site [nucleotide binding]; other site 813015232 predicted 30S ribosome binding site; other site 813015233 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 813015234 Protein of unknown function (DUF687); Region: DUF687; pfam05095 813015235 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 813015236 active site 813015237 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 813015238 triosephosphate isomerase; Provisional; Region: PRK14565 813015239 substrate binding site [chemical binding]; other site 813015240 dimer interface [polypeptide binding]; other site 813015241 catalytic triad [active] 813015242 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 813015243 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 813015244 generic binding surface II; other site 813015245 generic binding surface I; other site 813015246 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 813015247 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 813015248 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 813015249 TPP-binding site [chemical binding]; other site 813015250 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 813015251 PYR/PP interface [polypeptide binding]; other site 813015252 dimer interface [polypeptide binding]; other site 813015253 TPP binding site [chemical binding]; other site 813015254 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813015255 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 813015256 pyruvate kinase; Region: pyruv_kin; TIGR01064 813015257 domain interfaces; other site 813015258 active site 813015259 excinuclease ABC subunit A; Provisional; Region: PRK00635 813015260 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 813015261 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 813015262 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 813015263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813015264 Walker A/P-loop; other site 813015265 ATP binding site [chemical binding]; other site 813015266 Q-loop/lid; other site 813015267 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813015268 ABC transporter signature motif; other site 813015269 Walker B; other site 813015270 D-loop; other site 813015271 H-loop/switch region; other site 813015272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813015273 Walker A/P-loop; other site 813015274 ATP binding site [chemical binding]; other site 813015275 Q-loop/lid; other site 813015276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813015277 Q-loop/lid; other site 813015278 ABC transporter signature motif; other site 813015279 Walker B; other site 813015280 D-loop; other site 813015281 H-loop/switch region; other site 813015282 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 813015283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813015284 Walker A motif; other site 813015285 ATP binding site [chemical binding]; other site 813015286 Walker B motif; other site 813015287 arginine finger; other site 813015288 hypothetical protein; Validated; Region: PRK00153 813015289 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 813015290 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 813015291 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 813015292 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 813015293 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 813015294 Competence protein; Region: Competence; pfam03772 813015295 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 813015296 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 813015297 tetramer interface [polypeptide binding]; other site 813015298 TPP-binding site [chemical binding]; other site 813015299 heterodimer interface [polypeptide binding]; other site 813015300 phosphorylation loop region [posttranslational modification] 813015301 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 813015302 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 813015303 alpha subunit interface [polypeptide binding]; other site 813015304 TPP binding site [chemical binding]; other site 813015305 heterodimer interface [polypeptide binding]; other site 813015306 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813015307 chaperone protein DnaJ; Provisional; Region: PRK14284 813015308 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 813015309 HSP70 interaction site [polypeptide binding]; other site 813015310 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 813015311 Zn binding sites [ion binding]; other site 813015312 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 813015313 dimer interface [polypeptide binding]; other site 813015314 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 813015315 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 813015316 Glycoprotease family; Region: Peptidase_M22; pfam00814 813015317 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 813015318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813015319 Walker A motif; other site 813015320 ATP binding site [chemical binding]; other site 813015321 Walker B motif; other site 813015322 arginine finger; other site 813015323 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 813015324 ribonuclease Z; Region: RNase_Z; TIGR02651 813015325 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 813015326 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 813015327 active site 813015328 Int/Topo IB signature motif; other site 813015329 Maf-like protein; Region: Maf; pfam02545 813015330 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 813015331 active site 813015332 dimer interface [polypeptide binding]; other site 813015333 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 813015334 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 813015335 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 813015336 active site 813015337 catalytic residues [active] 813015338 metal binding site [ion binding]; metal-binding site 813015339 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 813015340 dimethyladenosine transferase; Region: ksgA; TIGR00755 813015341 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 813015342 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 813015343 catalytic residues [active] 813015344 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 813015345 dihydrodipicolinate synthase; Region: dapA; TIGR00674 813015346 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 813015347 inhibitor site; inhibition site 813015348 active site 813015349 dimer interface [polypeptide binding]; other site 813015350 catalytic residue [active] 813015351 aspartate kinase; Provisional; Region: PRK05925 813015352 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 813015353 putative catalytic residues [active] 813015354 nucleotide binding site [chemical binding]; other site 813015355 aspartate binding site [chemical binding]; other site 813015356 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 813015357 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 813015358 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 813015359 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 813015360 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 813015361 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 813015362 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 813015363 hinge; other site 813015364 active site 813015365 shikimate kinase; Provisional; Region: PRK00625 813015366 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 813015367 ADP binding site [chemical binding]; other site 813015368 magnesium binding site [ion binding]; other site 813015369 putative shikimate binding site; other site 813015370 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 813015371 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 813015372 Tetramer interface [polypeptide binding]; other site 813015373 active site 813015374 FMN-binding site [chemical binding]; other site 813015375 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 813015376 active site 813015377 dimer interface [polypeptide binding]; other site 813015378 metal binding site [ion binding]; metal-binding site 813015379 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 813015380 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 813015381 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 813015382 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 813015383 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 813015384 malate dehydrogenase; Provisional; Region: PRK05442 813015385 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 813015386 NAD(P) binding site [chemical binding]; other site 813015387 dimer interface [polypeptide binding]; other site 813015388 malate binding site [chemical binding]; other site 813015389 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 813015390 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 813015391 active site 813015392 dimer interface [polypeptide binding]; other site 813015393 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 813015394 dimer interface [polypeptide binding]; other site 813015395 active site 813015396 GTPases [General function prediction only]; Region: HflX; COG2262 813015397 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 813015398 HflX GTPase family; Region: HflX; cd01878 813015399 G1 box; other site 813015400 GTP/Mg2+ binding site [chemical binding]; other site 813015401 Switch I region; other site 813015402 G2 box; other site 813015403 G3 box; other site 813015404 Switch II region; other site 813015405 G4 box; other site 813015406 G5 box; other site 813015407 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 813015408 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 813015409 substrate binding pocket [chemical binding]; other site 813015410 membrane-bound complex binding site; other site 813015411 hinge residues; other site 813015412 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 813015413 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 813015414 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 813015415 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 813015416 nucleotide binding site/active site [active] 813015417 Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286 813015418 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 813015419 hypothetical protein; Validated; Region: PRK00647 813015420 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 813015421 ABC transporter substrate binding protein; Region: ABC_sub_bind; pfam04392 813015422 prolyl-tRNA synthetase; Provisional; Region: PRK09194 813015423 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 813015424 dimer interface [polypeptide binding]; other site 813015425 motif 1; other site 813015426 active site 813015427 motif 2; other site 813015428 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 813015429 putative deacylase active site [active] 813015430 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813015431 active site 813015432 motif 3; other site 813015433 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 813015434 anticodon binding site; other site 813015435 GrpE; Region: GrpE; pfam01025 813015436 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 813015437 dimer interface [polypeptide binding]; other site 813015438 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 813015439 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 813015440 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 813015441 nucleotide binding site [chemical binding]; other site 813015442 NEF interaction site [polypeptide binding]; other site 813015443 SBD interface [polypeptide binding]; other site 813015444 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 813015445 Exoribonuclease R [Transcription]; Region: VacB; COG0557 813015446 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 813015447 RNB domain; Region: RNB; pfam00773 813015448 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 813015449 Putative zinc ribbon domain; Region: DUF164; pfam02591 813015450 KpsF/GutQ family protein; Region: kpsF; TIGR00393 813015451 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 813015452 putative active site [active] 813015453 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 813015454 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 813015455 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813015456 E3 interaction surface; other site 813015457 lipoyl attachment site [posttranslational modification]; other site 813015458 e3 binding domain; Region: E3_binding; pfam02817 813015459 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813015460 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 813015461 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 813015462 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 813015463 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 813015464 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 813015465 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 813015466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813015467 S-adenosylmethionine binding site [chemical binding]; other site 813015468 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 813015469 Lumazine binding domain; Region: Lum_binding; pfam00677 813015470 Lumazine binding domain; Region: Lum_binding; pfam00677 813015471 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 813015472 ATP cone domain; Region: ATP-cone; pfam03477 813015473 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 813015474 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 813015475 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 813015476 amino acid carrier protein; Region: agcS; TIGR00835 813015477 poly(A) polymerase; Region: pcnB; TIGR01942 813015478 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 813015479 active site 813015480 NTP binding site [chemical binding]; other site 813015481 metal binding triad [ion binding]; metal-binding site 813015482 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 813015483 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 813015484 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 813015485 Predicted membrane protein [Function unknown]; Region: COG3952 813015486 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 813015487 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813015488 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813015489 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813015490 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813015491 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813015492 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813015493 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813015494 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813015495 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 813015496 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 813015497 intersubunit interface [polypeptide binding]; other site 813015498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813015499 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 813015500 Walker A/P-loop; other site 813015501 ATP binding site [chemical binding]; other site 813015502 Q-loop/lid; other site 813015503 ABC transporter signature motif; other site 813015504 Walker B; other site 813015505 D-loop; other site 813015506 H-loop/switch region; other site 813015507 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813015508 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813015509 ABC-ATPase subunit interface; other site 813015510 dimer interface [polypeptide binding]; other site 813015511 putative PBP binding regions; other site 813015512 GTPase CgtA; Reviewed; Region: obgE; PRK12299 813015513 GTP1/OBG; Region: GTP1_OBG; pfam01018 813015514 Obg GTPase; Region: Obg; cd01898 813015515 G1 box; other site 813015516 GTP/Mg2+ binding site [chemical binding]; other site 813015517 Switch I region; other site 813015518 G2 box; other site 813015519 G3 box; other site 813015520 Switch II region; other site 813015521 G4 box; other site 813015522 G5 box; other site 813015523 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 813015524 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 813015525 Uncharacterized conserved protein [Function unknown]; Region: COG2928 813015526 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 813015527 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 813015528 FOG: CBS domain [General function prediction only]; Region: COG0517 813015529 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813015530 Transporter associated domain; Region: CorC_HlyC; smart01091 813015531 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 813015532 anti sigma factor interaction site; other site 813015533 regulatory phosphorylation site [posttranslational modification]; other site 813015534 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 813015535 hypothetical protein; Provisional; Region: PRK05926 813015536 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813015537 FeS/SAM binding site; other site 813015538 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 813015539 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 813015540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813015541 S-adenosylmethionine binding site [chemical binding]; other site 813015542 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 813015543 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 813015544 diaminopimelate epimerase; Region: DapF; TIGR00652 813015545 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 813015546 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 813015547 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 813015548 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 813015549 active site 813015550 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 813015551 homotrimer interaction site [polypeptide binding]; other site 813015552 zinc binding site [ion binding]; other site 813015553 CDP-binding sites; other site 813015554 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 813015555 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 813015556 FAD binding pocket [chemical binding]; other site 813015557 conserved FAD binding motif [chemical binding]; other site 813015558 phosphate binding motif [ion binding]; other site 813015559 beta-alpha-beta structure motif; other site 813015560 NAD binding pocket [chemical binding]; other site 813015561 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 813015562 elongation factor G; Reviewed; Region: PRK12739 813015563 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 813015564 G1 box; other site 813015565 putative GEF interaction site [polypeptide binding]; other site 813015566 GTP/Mg2+ binding site [chemical binding]; other site 813015567 Switch I region; other site 813015568 G2 box; other site 813015569 G3 box; other site 813015570 Switch II region; other site 813015571 G4 box; other site 813015572 G5 box; other site 813015573 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 813015574 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 813015575 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 813015576 30S ribosomal protein S7; Validated; Region: PRK05302 813015577 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 813015578 S17 interaction site [polypeptide binding]; other site 813015579 S8 interaction site; other site 813015580 16S rRNA interaction site [nucleotide binding]; other site 813015581 streptomycin interaction site [chemical binding]; other site 813015582 23S rRNA interaction site [nucleotide binding]; other site 813015583 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 813015584 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 813015585 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 813015586 protein binding site [polypeptide binding]; other site 813015587 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 813015588 Catalytic dyad [active] 813015589 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 813015590 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 813015591 Domain of unknown function DUF11; Region: DUF11; pfam01345 813015592 Domain of unknown function DUF11; Region: DUF11; pfam01345 813015593 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 813015594 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 813015595 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 813015596 HIGH motif; other site 813015597 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 813015598 active site 813015599 KMSKS motif; other site 813015600 Helix-turn-helix domain; Region: HTH_17; pfam12728 813015601 Helix-turn-helix domain; Region: HTH_17; pfam12728 813015602 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 813015603 DHH family; Region: DHH; pfam01368 813015604 DHHA1 domain; Region: DHHA1; pfam02272 813015605 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 813015606 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 813015607 Protein export membrane protein; Region: SecD_SecF; pfam02355 813015608 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 813015609 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 813015610 catalytic residue [active] 813015611 putative FPP diphosphate binding site; other site 813015612 putative FPP binding hydrophobic cleft; other site 813015613 dimer interface [polypeptide binding]; other site 813015614 putative IPP diphosphate binding site; other site 813015615 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 813015616 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 813015617 CMP-binding site; other site 813015618 The sites determining sugar specificity; other site 813015619 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 813015620 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 813015621 putative acyl-acceptor binding pocket; other site 813015622 arginine-tRNA ligase; Region: PLN02286 813015623 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 813015624 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 813015625 active site 813015626 HIGH motif; other site 813015627 KMSK motif region; other site 813015628 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813015629 tRNA binding surface [nucleotide binding]; other site 813015630 anticodon binding site; other site 813015631 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 813015632 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 813015633 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 813015634 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 813015635 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 813015636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 813015637 Coenzyme A binding pocket [chemical binding]; other site 813015638 PCRF domain; Region: PCRF; pfam03462 813015639 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 813015640 RF-1 domain; Region: RF-1; pfam00472 813015641 SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531 813015642 SWI complex, BAF60b domains; Region: SWIB; smart00151 813015643 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 813015644 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813015645 putative active site [active] 813015646 putative metal binding site [ion binding]; other site 813015647 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 813015648 substrate binding site; other site 813015649 dimer interface; other site 813015650 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 813015651 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 813015652 dimerization interface 3.5A [polypeptide binding]; other site 813015653 active site 813015654 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 813015655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 813015656 active site 813015657 motif I; other site 813015658 motif II; other site 813015659 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 813015660 PAS domain; Region: PAS; smart00091 813015661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 813015662 dimer interface [polypeptide binding]; other site 813015663 phosphorylation site [posttranslational modification] 813015664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813015665 ATP binding site [chemical binding]; other site 813015666 Mg2+ binding site [ion binding]; other site 813015667 G-X-G motif; other site 813015668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 813015669 Response regulator receiver domain; Region: Response_reg; pfam00072 813015670 active site 813015671 phosphorylation site [posttranslational modification] 813015672 intermolecular recognition site; other site 813015673 dimerization interface [polypeptide binding]; other site 813015674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813015675 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 813015676 Walker A motif; other site 813015677 ATP binding site [chemical binding]; other site 813015678 Walker B motif; other site 813015679 arginine finger; other site 813015680 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 813015681 Recombination protein O N terminal; Region: RecO_N; pfam11967 813015682 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 813015683 Recombination protein O C terminal; Region: RecO_C; pfam02565 813015684 Uncharacterized conserved protein [Function unknown]; Region: COG1723 813015685 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 813015686 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 813015687 putative tRNA-binding site [nucleotide binding]; other site 813015688 B3/4 domain; Region: B3_4; pfam03483 813015689 tRNA synthetase B5 domain; Region: B5; smart00874 813015690 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 813015691 dimer interface [polypeptide binding]; other site 813015692 motif 1; other site 813015693 motif 3; other site 813015694 motif 2; other site 813015695 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 813015696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813015697 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 813015698 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 813015699 DNA binding site [nucleotide binding] 813015700 active site 813015701 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 813015702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813015703 dimer interface [polypeptide binding]; other site 813015704 conserved gate region; other site 813015705 putative PBP binding loops; other site 813015706 ABC-ATPase subunit interface; other site 813015707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 813015708 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 813015709 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 813015710 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 813015711 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 813015712 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 813015713 putative active site [active] 813015714 putative metal binding site [ion binding]; other site 813015715 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813015716 binding surface 813015717 TPR motif; other site 813015718 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 813015719 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 813015720 C-terminal domain interface [polypeptide binding]; other site 813015721 active site 813015722 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 813015723 active site 813015724 N-terminal domain interface [polypeptide binding]; other site 813015725 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 813015726 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 813015727 substrate binding pocket [chemical binding]; other site 813015728 membrane-bound complex binding site; other site 813015729 hinge residues; other site 813015730 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 813015731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813015732 S-adenosylmethionine binding site [chemical binding]; other site 813015733 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 813015734 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813015735 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 813015736 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 813015737 ligand binding site; other site 813015738 oligomer interface; other site 813015739 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 813015740 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 813015741 N-terminal domain interface [polypeptide binding]; other site 813015742 sulfate 1 binding site; other site 813015743 transcription termination factor Rho; Region: rho; TIGR00767 813015744 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 813015745 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 813015746 RNA binding site [nucleotide binding]; other site 813015747 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 813015748 multimer interface [polypeptide binding]; other site 813015749 Walker A motif; other site 813015750 ATP binding site [chemical binding]; other site 813015751 Walker B motif; other site 813015752 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 813015753 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 813015754 CoA-binding site [chemical binding]; other site 813015755 ATP-binding [chemical binding]; other site 813015756 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 813015757 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 813015758 tandem repeat interface [polypeptide binding]; other site 813015759 oligomer interface [polypeptide binding]; other site 813015760 active site residues [active] 813015761 TLC ATP/ADP transporter; Region: TLC; pfam03219 813015762 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 813015763 replicative DNA helicase; Provisional; Region: PRK06321 813015764 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 813015765 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 813015766 Walker A motif; other site 813015767 ATP binding site [chemical binding]; other site 813015768 Walker B motif; other site 813015769 DNA binding loops [nucleotide binding] 813015770 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 813015771 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 813015772 RuvA N terminal domain; Region: RuvA_N; pfam01330 813015773 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 813015774 active site 813015775 putative DNA-binding cleft [nucleotide binding]; other site 813015776 dimer interface [polypeptide binding]; other site 813015777 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 813015778 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 813015779 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 813015780 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 813015781 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 813015782 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 813015783 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 813015784 alphaNTD - beta interaction site [polypeptide binding]; other site 813015785 alphaNTD homodimer interface [polypeptide binding]; other site 813015786 alphaNTD - beta' interaction site [polypeptide binding]; other site 813015787 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 813015788 30S ribosomal protein S11; Validated; Region: PRK05309 813015789 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 813015790 30S ribosomal protein S13; Region: bact_S13; TIGR03631 813015791 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 813015792 SecY translocase; Region: SecY; pfam00344 813015793 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 813015794 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 813015795 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 813015796 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 813015797 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 813015798 5S rRNA interface [nucleotide binding]; other site 813015799 23S rRNA interface [nucleotide binding]; other site 813015800 L5 interface [polypeptide binding]; other site 813015801 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 813015802 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 813015803 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 813015804 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 813015805 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 813015806 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 813015807 RNA binding site [nucleotide binding]; other site 813015808 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 813015809 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 813015810 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 813015811 23S rRNA interface [nucleotide binding]; other site 813015812 putative translocon interaction site; other site 813015813 signal recognition particle (SRP54) interaction site; other site 813015814 L23 interface [polypeptide binding]; other site 813015815 trigger factor interaction site; other site 813015816 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 813015817 23S rRNA interface [nucleotide binding]; other site 813015818 5S rRNA interface [nucleotide binding]; other site 813015819 putative antibiotic binding site [chemical binding]; other site 813015820 L25 interface [polypeptide binding]; other site 813015821 L27 interface [polypeptide binding]; other site 813015822 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 813015823 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 813015824 G-X-X-G motif; other site 813015825 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 813015826 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 813015827 putative translocon binding site; other site 813015828 protein-rRNA interface [nucleotide binding]; other site 813015829 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 813015830 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 813015831 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 813015832 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 813015833 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 813015834 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 813015835 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 813015836 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 813015837 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 813015838 putative active site [active] 813015839 substrate binding site [chemical binding]; other site 813015840 putative cosubstrate binding site; other site 813015841 catalytic site [active] 813015842 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 813015843 substrate binding site [chemical binding]; other site 813015844 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 813015845 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 813015846 active site 813015847 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 813015848 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 813015849 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 813015850 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 813015851 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 813015852 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 813015853 active site 813015854 catalytic site [active] 813015855 substrate binding site [chemical binding]; other site 813015856 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 813015857 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 813015858 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 813015859 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 813015860 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813015861 catalytic residues [active] 813015862 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 813015863 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 813015864 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 813015865 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 813015866 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 813015867 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 813015868 dimer interface [polypeptide binding]; other site 813015869 anticodon binding site; other site 813015870 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 813015871 homodimer interface [polypeptide binding]; other site 813015872 motif 1; other site 813015873 active site 813015874 motif 2; other site 813015875 GAD domain; Region: GAD; pfam02938 813015876 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813015877 active site 813015878 motif 3; other site 813015879 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 813015880 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 813015881 dimer interface [polypeptide binding]; other site 813015882 motif 1; other site 813015883 active site 813015884 motif 2; other site 813015885 motif 3; other site 813015886 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 813015887 anticodon binding site; other site 813015888 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 813015889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813015890 putative substrate translocation pore; other site 813015891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813015892 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 813015893 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 813015894 active site 813015895 PHP Thumb interface [polypeptide binding]; other site 813015896 metal binding site [ion binding]; metal-binding site 813015897 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 813015898 generic binding surface I; other site 813015899 generic binding surface II; other site 813015900 TPR repeat; Region: TPR_11; pfam13414 813015901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813015902 binding surface 813015903 TPR motif; other site 813015904 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 813015905 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 813015906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 813015907 Mg2+ binding site [ion binding]; other site 813015908 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 813015909 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 813015910 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 813015911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813015912 S-adenosylmethionine binding site [chemical binding]; other site 813015913 branched-chain amino acid uptake carrier; Region: livcs; TIGR00796 813015914 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 813015915 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813015916 ATP binding site [chemical binding]; other site 813015917 putative Mg++ binding site [ion binding]; other site 813015918 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813015919 ATP-binding site [chemical binding]; other site 813015920 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 813015921 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 813015922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 813015923 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 813015924 lipoate synthase; Region: lipA; TIGR00510 813015925 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813015926 FeS/SAM binding site; other site 813015927 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 813015928 type III secretion system protein; Validated; Region: PRK06328 813015929 Flagellar assembly protein FliH; Region: FliH; pfam02108 813015930 type III secretion system protein; Reviewed; Region: PRK09617 813015931 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 813015932 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 813015933 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 813015934 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 813015935 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 813015936 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 813015937 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 813015938 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 813015939 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 813015940 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 813015941 Walker A motif; other site 813015942 ATP binding site [chemical binding]; other site 813015943 Walker B motif; other site 813015944 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 813015945 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813015946 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 813015947 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 813015948 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 813015949 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 813015950 active site 813015951 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 813015952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813015953 ATP binding site [chemical binding]; other site 813015954 Mg2+ binding site [ion binding]; other site 813015955 G-X-G motif; other site 813015956 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 813015957 ATP binding site [chemical binding]; other site 813015958 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 813015959 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 813015960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813015961 binding surface 813015962 TPR motif; other site 813015963 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 813015964 EamA-like transporter family; Region: EamA; pfam00892 813015965 EamA-like transporter family; Region: EamA; pfam00892 813015966 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 813015967 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 813015968 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 813015969 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 813015970 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 813015971 active site 813015972 HIGH motif; other site 813015973 dimer interface [polypeptide binding]; other site 813015974 KMSKS motif; other site 813015975 excinuclease ABC subunit B; Provisional; Region: PRK05298 813015976 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813015977 ATP binding site [chemical binding]; other site 813015978 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813015979 nucleotide binding region [chemical binding]; other site 813015980 ATP-binding site [chemical binding]; other site 813015981 Ultra-violet resistance protein B; Region: UvrB; pfam12344 813015982 enolase; Provisional; Region: eno; PRK00077 813015983 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 813015984 dimer interface [polypeptide binding]; other site 813015985 metal binding site [ion binding]; metal-binding site 813015986 substrate binding pocket [chemical binding]; other site 813015987 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 813015988 HAMP domain; Region: HAMP; pfam00672 813015989 dimerization interface [polypeptide binding]; other site 813015990 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 813015991 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 813015992 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 813015993 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 813015994 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 813015995 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 813015996 Iron-sulfur protein interface; other site 813015997 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 813015998 proximal heme binding site [chemical binding]; other site 813015999 Iron-sulfur protein interface; other site 813016000 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 813016001 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 813016002 active site 813016003 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 813016004 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 813016005 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 813016006 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 813016007 DsbD alpha interface [polypeptide binding]; other site 813016008 catalytic residues [active] 813016009 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 813016010 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 813016011 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 813016012 translocation protein TolB; Provisional; Region: tolB; PRK01029 813016013 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813016014 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813016015 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813016016 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 813016017 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 813016018 ligand binding site [chemical binding]; other site 813016019 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 813016020 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813016021 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 813016022 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 813016023 dimer interface [polypeptide binding]; other site 813016024 decamer (pentamer of dimers) interface [polypeptide binding]; other site 813016025 catalytic triad [active] 813016026 peroxidatic and resolving cysteines [active] 813016027 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 813016028 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 813016029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 813016030 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 813016031 ligand binding site [chemical binding]; other site 813016032 active site 813016033 UGI interface [polypeptide binding]; other site 813016034 catalytic site [active] 813016035 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 813016036 Part of AAA domain; Region: AAA_19; pfam13245 813016037 Family description; Region: UvrD_C_2; pfam13538 813016038 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 813016039 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 813016040 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 813016041 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 813016042 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 813016043 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 813016044 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 813016045 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 813016046 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 813016047 folate binding site [chemical binding]; other site 813016048 NADP+ binding site [chemical binding]; other site 813016049 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 813016050 catalytic center binding site [active] 813016051 ATP binding site [chemical binding]; other site 813016052 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 813016053 dihydropteroate synthase; Region: DHPS; TIGR01496 813016054 substrate binding pocket [chemical binding]; other site 813016055 dimer interface [polypeptide binding]; other site 813016056 inhibitor binding site; inhibition site 813016057 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 813016058 homooctamer interface [polypeptide binding]; other site 813016059 active site 813016060 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 813016061 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 813016062 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 813016063 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 813016064 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 813016065 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 813016066 DNA binding residues [nucleotide binding] 813016067 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 813016068 Effector from type III secretion system; Region: Effector_1; pfam04518 813016069 Effector from type III secretion system; Region: Effector_1; pfam04518 813016070 Effector from type III secretion system; Region: Effector_1; pfam04518 813016071 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 813016072 endonuclease IV; Provisional; Region: PRK01060 813016073 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 813016074 AP (apurinic/apyrimidinic) site pocket; other site 813016075 DNA interaction; other site 813016076 Metal-binding active site; metal-binding site 813016077 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 813016078 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 813016079 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813016080 RNA binding surface [nucleotide binding]; other site 813016081 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 813016082 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 813016083 active site residue [active] 813016084 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 813016085 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 813016086 substrate binding pocket [chemical binding]; other site 813016087 chain length determination region; other site 813016088 substrate-Mg2+ binding site; other site 813016089 catalytic residues [active] 813016090 aspartate-rich region 1; other site 813016091 active site lid residues [active] 813016092 aspartate-rich region 2; other site 813016093 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 813016094 putative trimer interface [polypeptide binding]; other site 813016095 putative CoA binding site [chemical binding]; other site 813016096 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 813016097 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 813016098 DNA binding site [nucleotide binding] 813016099 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 813016100 Thymidylate synthase complementing protein; Region: Thy1; cl03630 813016101 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 813016102 dimer interface [polypeptide binding]; other site 813016103 active site 813016104 aspartate-rich active site metal binding site; other site 813016105 allosteric magnesium binding site [ion binding]; other site 813016106 Schiff base residues; other site 813016107 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 813016108 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 813016109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813016110 homodimer interface [polypeptide binding]; other site 813016111 catalytic residue [active] 813016112 rod shape-determining protein MreC; Provisional; Region: PRK14872 813016113 rod shape-determining protein MreC; Region: MreC; pfam04085 813016114 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 813016115 Part of AAA domain; Region: AAA_19; pfam13245 813016116 Family description; Region: UvrD_C_2; pfam13538 813016117 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 813016118 Major Facilitator Superfamily; Region: MFS_1; pfam07690 813016119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813016120 putative substrate translocation pore; other site 813016121 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 813016122 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 813016123 active site 813016124 interdomain interaction site; other site 813016125 putative metal-binding site [ion binding]; other site 813016126 nucleotide binding site [chemical binding]; other site 813016127 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 813016128 domain I; other site 813016129 DNA binding groove [nucleotide binding] 813016130 phosphate binding site [ion binding]; other site 813016131 domain II; other site 813016132 domain III; other site 813016133 nucleotide binding site [chemical binding]; other site 813016134 catalytic site [active] 813016135 domain IV; other site 813016136 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813016137 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813016138 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813016139 SWI complex, BAF60b domains; Region: SWIB; smart00151 813016140 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 813016141 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 813016142 FMN binding site [chemical binding]; other site 813016143 active site 813016144 catalytic residues [active] 813016145 substrate binding site [chemical binding]; other site 813016146 Predicted integral membrane protein [Function unknown]; Region: COG0762 813016147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813016148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813016149 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 813016150 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 813016151 recombinase A; Provisional; Region: recA; PRK09354 813016152 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 813016153 hexamer interface [polypeptide binding]; other site 813016154 Walker A motif; other site 813016155 ATP binding site [chemical binding]; other site 813016156 Walker B motif; other site 813016157 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 813016158 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 813016159 AAA domain; Region: AAA_30; pfam13604 813016160 Family description; Region: UvrD_C_2; pfam13538 813016161 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 813016162 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 813016163 Walker A/P-loop; other site 813016164 ATP binding site [chemical binding]; other site 813016165 Q-loop/lid; other site 813016166 ABC transporter signature motif; other site 813016167 Walker B; other site 813016168 D-loop; other site 813016169 H-loop/switch region; other site 813016170 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 813016171 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 813016172 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 813016173 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 813016174 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813016175 RNA binding surface [nucleotide binding]; other site 813016176 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 813016177 active site 813016178 hypothetical protein; Provisional; Region: PRK01064 813016179 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 813016180 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 813016181 DNA Topoisomerase IV; Region: TOP4c; smart00434 813016182 CAP-like domain; other site 813016183 active site 813016184 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 813016185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813016186 ATP binding site [chemical binding]; other site 813016187 Mg2+ binding site [ion binding]; other site 813016188 G-X-G motif; other site 813016189 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 813016190 ATP binding site [chemical binding]; other site 813016191 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 813016192 active site 813016193 putative metal-binding site [ion binding]; other site 813016194 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 813016195 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 813016196 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 813016197 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813016198 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 813016199 phosphopeptide binding site; other site 813016200 MARCKS family; Region: MARCKS; pfam02063 813016201 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 813016202 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 813016203 phosphopeptide binding site; other site 813016204 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 813016205 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 813016206 binding surface 813016207 Tetratricopeptide repeat; Region: TPR_16; pfam13432 813016208 TPR motif; other site 813016209 type III secretion system ATPase; Provisional; Region: PRK06315 813016210 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813016211 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 813016212 Walker A motif/ATP binding site; other site 813016213 Walker B motif; other site 813016214 type III secretion system protein; Validated; Region: PRK05933 813016215 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 813016216 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 813016217 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813016218 active site 813016219 ATP binding site [chemical binding]; other site 813016220 substrate binding site [chemical binding]; other site 813016221 activation loop (A-loop); other site 813016222 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 813016223 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813016224 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813016225 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 813016226 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 813016227 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 813016228 ADP binding site [chemical binding]; other site 813016229 phosphagen binding site; other site 813016230 substrate specificity loop; other site 813016231 ribosome recycling factor; Reviewed; Region: frr; PRK00083 813016232 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 813016233 hinge region; other site 813016234 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 813016235 putative nucleotide binding site [chemical binding]; other site 813016236 uridine monophosphate binding site [chemical binding]; other site 813016237 homohexameric interface [polypeptide binding]; other site 813016238 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 813016239 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 813016240 Elongation factor TS; Region: EF_TS; pfam00889 813016241 Elongation factor TS; Region: EF_TS; pfam00889 813016242 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 813016243 rRNA interaction site [nucleotide binding]; other site 813016244 S8 interaction site; other site 813016245 putative laminin-1 binding site; other site 813016246 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 813016247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813016248 TPR motif; other site 813016249 Tetratricopeptide repeat; Region: TPR_16; pfam13432 813016250 binding surface 813016251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813016252 binding surface 813016253 TPR motif; other site 813016254 TPR repeat; Region: TPR_11; pfam13414 813016255 TPR repeat; Region: TPR_11; pfam13414 813016256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813016257 binding surface 813016258 TPR motif; other site 813016259 TPR repeat; Region: TPR_11; pfam13414 813016260 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 813016261 putative ABC transporter; Region: ycf24; CHL00085 813016262 FeS assembly ATPase SufC; Region: sufC; TIGR01978 813016263 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 813016264 Walker A/P-loop; other site 813016265 ATP binding site [chemical binding]; other site 813016266 Q-loop/lid; other site 813016267 ABC transporter signature motif; other site 813016268 Walker B; other site 813016269 D-loop; other site 813016270 H-loop/switch region; other site 813016271 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 813016272 FeS assembly protein SufD; Region: sufD; TIGR01981 813016273 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 813016274 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 813016275 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813016276 catalytic residue [active] 813016277 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 813016278 ParB-like nuclease domain; Region: ParBc; pfam02195 813016279 KorB domain; Region: KorB; pfam08535 813016280 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 813016281 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813016282 Walker A/P-loop; other site 813016283 ATP binding site [chemical binding]; other site 813016284 Q-loop/lid; other site 813016285 ABC transporter signature motif; other site 813016286 Walker B; other site 813016287 D-loop; other site 813016288 H-loop/switch region; other site 813016289 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813016290 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 813016291 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 813016292 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 813016293 Phosphoglycerate kinase; Region: PGK; pfam00162 813016294 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 813016295 substrate binding site [chemical binding]; other site 813016296 hinge regions; other site 813016297 ADP binding site [chemical binding]; other site 813016298 catalytic site [active] 813016299 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 813016300 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 813016301 minor groove reading motif; other site 813016302 helix-hairpin-helix signature motif; other site 813016303 substrate binding pocket [chemical binding]; other site 813016304 active site 813016305 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 813016306 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 813016307 trmE is a tRNA modification GTPase; Region: trmE; cd04164 813016308 G1 box; other site 813016309 GTP/Mg2+ binding site [chemical binding]; other site 813016310 Switch I region; other site 813016311 G2 box; other site 813016312 Switch II region; other site 813016313 G3 box; other site 813016314 G4 box; other site 813016315 G5 box; other site 813016316 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 813016317 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 813016318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813016319 binding surface 813016320 TPR motif; other site 813016321 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 813016322 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 813016323 ATP binding site [chemical binding]; other site 813016324 putative Mg++ binding site [ion binding]; other site 813016325 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 813016326 Predicted GTPases [General function prediction only]; Region: COG1160 813016327 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 813016328 G1 box; other site 813016329 GTP/Mg2+ binding site [chemical binding]; other site 813016330 Switch I region; other site 813016331 G2 box; other site 813016332 Switch II region; other site 813016333 G3 box; other site 813016334 G4 box; other site 813016335 G5 box; other site 813016336 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 813016337 G1 box; other site 813016338 GTP/Mg2+ binding site [chemical binding]; other site 813016339 Switch I region; other site 813016340 G2 box; other site 813016341 G3 box; other site 813016342 Switch II region; other site 813016343 G4 box; other site 813016344 G5 box; other site 813016345 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 813016346 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 813016347 active site 813016348 NTP binding site [chemical binding]; other site 813016349 metal binding triad [ion binding]; metal-binding site 813016350 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 813016351 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 813016352 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 813016353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813016354 Walker A motif; other site 813016355 ATP binding site [chemical binding]; other site 813016356 Walker B motif; other site 813016357 arginine finger; other site 813016358 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 813016359 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 813016360 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 813016361 oligomer interface [polypeptide binding]; other site 813016362 active site residues [active] 813016363 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 813016364 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 813016365 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 813016366 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 813016367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813016368 ATP binding site [chemical binding]; other site 813016369 putative Mg++ binding site [ion binding]; other site 813016370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813016371 nucleotide binding region [chemical binding]; other site 813016372 ATP-binding site [chemical binding]; other site 813016373 rod shape-determining protein MreB; Provisional; Region: PRK13927 813016374 MreB and similar proteins; Region: MreB_like; cd10225 813016375 nucleotide binding site [chemical binding]; other site 813016376 Mg binding site [ion binding]; other site 813016377 putative protofilament interaction site [polypeptide binding]; other site 813016378 RodZ interaction site [polypeptide binding]; other site 813016379 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 813016380 active site 813016381 substrate-binding site [chemical binding]; other site 813016382 metal-binding site [ion binding] 813016383 GTP binding site [chemical binding]; other site 813016384 Effector from type III secretion system; Region: Effector_1; pfam04518 813016385 Effector from type III secretion system; Region: Effector_1; pfam04518 813016386 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 813016387 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 813016388 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 813016389 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 813016390 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 813016391 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 813016392 active site 813016393 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 813016394 type III secretion system ATPase; Validated; Region: PRK05922 813016395 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813016396 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 813016397 Walker A motif; other site 813016398 ATP binding site [chemical binding]; other site 813016399 Walker B motif; other site 813016400 type III secretion system protein; Validated; Region: PRK05934 813016401 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 813016402 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 813016403 active site 813016404 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 813016405 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 813016406 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813016407 catalytic residue [active] 813016408 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 813016409 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813016410 RNA binding surface [nucleotide binding]; other site 813016411 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 813016412 active site 813016413 biotin--protein ligase; Provisional; Region: PRK05935 813016414 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 813016415 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 813016416 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 813016417 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 813016418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 813016419 motif II; other site 813016420 CCC1-related protein family; Region: CCC1_like_1; cd02437 813016421 seryl-tRNA synthetase; Provisional; Region: PRK05431 813016422 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 813016423 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 813016424 dimer interface [polypeptide binding]; other site 813016425 active site 813016426 motif 1; other site 813016427 motif 2; other site 813016428 motif 3; other site 813016429 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 813016430 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 813016431 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 813016432 dimerization interface [polypeptide binding]; other site 813016433 active site 813016434 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 813016435 homopentamer interface [polypeptide binding]; other site 813016436 active site 813016437 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 813016438 substrate binding site [chemical binding]; other site 813016439 Proteins containing SET domain [General function prediction only]; Region: COG2940 813016440 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 813016441 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 813016442 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 813016443 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 813016444 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 813016445 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 813016446 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 813016447 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 813016448 catalytic loop [active] 813016449 iron binding site [ion binding]; other site 813016450 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 813016451 FAD binding pocket [chemical binding]; other site 813016452 FAD binding motif [chemical binding]; other site 813016453 phosphate binding motif [ion binding]; other site 813016454 beta-alpha-beta structure motif; other site 813016455 NAD binding pocket [chemical binding]; other site 813016456 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 813016457 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 813016458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813016459 S-adenosylmethionine binding site [chemical binding]; other site 813016460 Histone H1-like protein Hc1; Region: Hc1; pfam07432 813016461 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 813016462 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 813016463 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 813016464 HemN C-terminal domain; Region: HemN_C; pfam06969 813016465 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 813016466 substrate binding site [chemical binding]; other site 813016467 active site 813016468 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 813016469 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 813016470 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813016471 ATP binding site [chemical binding]; other site 813016472 putative Mg++ binding site [ion binding]; other site 813016473 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813016474 nucleotide binding region [chemical binding]; other site 813016475 ATP-binding site [chemical binding]; other site 813016476 TRCF domain; Region: TRCF; pfam03461 813016477 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 813016478 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 813016479 motif 1; other site 813016480 active site 813016481 motif 2; other site 813016482 motif 3; other site 813016483 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 813016484 DHHA1 domain; Region: DHHA1; pfam02272 813016485 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 813016486 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 813016487 TPP-binding site [chemical binding]; other site 813016488 dimer interface [polypeptide binding]; other site 813016489 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 813016490 PYR/PP interface [polypeptide binding]; other site 813016491 dimer interface [polypeptide binding]; other site 813016492 TPP binding site [chemical binding]; other site 813016493 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813016494 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 813016495 elongation factor P; Validated; Region: PRK00529 813016496 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 813016497 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 813016498 RNA binding site [nucleotide binding]; other site 813016499 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 813016500 RNA binding site [nucleotide binding]; other site 813016501 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813016502 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 813016503 putative active site [active] 813016504 putative metal binding site [ion binding]; other site 813016505 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 813016506 active site 813016507 metal binding site [ion binding]; metal-binding site 813016508 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 813016509 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 813016510 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 813016511 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813016512 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813016513 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 813016514 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 813016515 Mg++ binding site [ion binding]; other site 813016516 putative catalytic motif [active] 813016517 putative substrate binding site [chemical binding]; other site 813016518 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 813016519 TrkA-N domain; Region: TrkA_N; pfam02254 813016520 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813016521 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813016522 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 813016523 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813016524 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813016525 cell division protein FtsW; Region: ftsW; TIGR02614 813016526 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 813016527 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 813016528 active site 813016529 homodimer interface [polypeptide binding]; other site 813016530 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 813016531 anti sigma factor interaction site; other site 813016532 regulatory phosphorylation site [posttranslational modification]; other site 813016533 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 813016534 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 813016535 hypothetical protein; Provisional; Region: PRK05927 813016536 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 813016537 FeS/SAM binding site; other site 813016538 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813016539 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 813016540 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 813016541 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 813016542 dimer interface [polypeptide binding]; other site 813016543 active site 813016544 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 813016545 active site 813016546 Ap4A binding cleft/pocket [chemical binding]; other site 813016547 P4 phosphate binding site; other site 813016548 nudix motif; other site 813016549 putative P2/P3 phosphate binding site [ion binding]; other site 813016550 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 813016551 dimer interface [polypeptide binding]; other site 813016552 substrate binding site [chemical binding]; other site 813016553 metal binding sites [ion binding]; metal-binding site 813016554 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 813016555 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 813016556 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 813016557 NAD binding site [chemical binding]; other site 813016558 Phe binding site; other site 813016559 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 813016560 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 813016561 active site 813016562 putative lithium-binding site [ion binding]; other site 813016563 substrate binding site [chemical binding]; other site 813016564 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 813016565 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 813016566 putative acyl-acceptor binding pocket; other site 813016567 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 813016568 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 813016569 acyl-activating enzyme (AAE) consensus motif; other site 813016570 AMP binding site [chemical binding]; other site 813016571 active site 813016572 CoA binding site [chemical binding]; other site 813016573 8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937 813016574 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 813016575 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813016576 catalytic residue [active] 813016577 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 813016578 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813016579 ATP binding site [chemical binding]; other site 813016580 putative Mg++ binding site [ion binding]; other site 813016581 helicase superfamily c-terminal domain; Region: HELICc; smart00490 813016582 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 813016583 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813016584 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 813016585 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 813016586 dimer interface [polypeptide binding]; other site 813016587 putative anticodon binding site; other site 813016588 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813016589 motif 1; other site 813016590 dimer interface [polypeptide binding]; other site 813016591 active site 813016592 motif 2; other site 813016593 motif 3; other site 813016594 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 813016595 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 813016596 active site 813016597 HIGH motif; other site 813016598 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 813016599 KMSKS motif; other site 813016600 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813016601 tRNA binding surface [nucleotide binding]; other site 813016602 anticodon binding site; other site 813016603 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 813016604 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813016605 ribonuclease P; Reviewed; Region: rnpA; PRK00730 813016606 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 813016607 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 813016608 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 813016609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 813016610 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 813016611 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 813016612 GIY-YIG motif/motif A; other site 813016613 active site 813016614 catalytic site [active] 813016615 putative DNA binding site [nucleotide binding]; other site 813016616 metal binding site [ion binding]; metal-binding site 813016617 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 813016618 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 813016619 MutS domain I; Region: MutS_I; pfam01624 813016620 MutS domain II; Region: MutS_II; pfam05188 813016621 MutS domain III; Region: MutS_III; pfam05192 813016622 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 813016623 Walker A/P-loop; other site 813016624 ATP binding site [chemical binding]; other site 813016625 Q-loop/lid; other site 813016626 ABC transporter signature motif; other site 813016627 Walker B; other site 813016628 D-loop; other site 813016629 H-loop/switch region; other site 813016630 DNA primase; Validated; Region: dnaG; PRK05667 813016631 CHC2 zinc finger; Region: zf-CHC2; pfam01807 813016632 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 813016633 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 813016634 active site 813016635 metal binding site [ion binding]; metal-binding site 813016636 interdomain interaction site; other site 813016637 glycyl-tRNA synthetase; Provisional; Region: PRK14908 813016638 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 813016639 dimer interface [polypeptide binding]; other site 813016640 motif 1; other site 813016641 active site 813016642 motif 2; other site 813016643 motif 3; other site 813016644 DALR anticodon binding domain; Region: DALR_1; pfam05746 813016645 glycogen synthase; Provisional; Region: glgA; PRK00654 813016646 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 813016647 ADP-binding pocket [chemical binding]; other site 813016648 homodimer interface [polypeptide binding]; other site 813016649 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 813016650 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 813016651 5S rRNA interface [nucleotide binding]; other site 813016652 CTC domain interface [polypeptide binding]; other site 813016653 L16 interface [polypeptide binding]; other site 813016654 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 813016655 putative active site [active] 813016656 catalytic residue [active] 813016657 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 813016658 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 813016659 Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359 813016660 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 813016661 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 813016662 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 813016663 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 813016664 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813016665 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813016666 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 813016667 putative acyl-acceptor binding pocket; other site 813016668 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 813016669 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 813016670 homodimer interface [polypeptide binding]; other site 813016671 oligonucleotide binding site [chemical binding]; other site 813016672 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 813016673 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 813016674 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813016675 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813016676 YtxH-like protein; Region: YtxH; cl02079 813016677 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 813016678 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 813016679 active site 813016680 substrate binding site [chemical binding]; other site 813016681 metal binding site [ion binding]; metal-binding site 813016682 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 813016683 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 813016684 glutaminase active site [active] 813016685 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 813016686 dimer interface [polypeptide binding]; other site 813016687 active site 813016688 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 813016689 dimer interface [polypeptide binding]; other site 813016690 active site 813016691 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 813016692 aromatic amino acid transport protein; Region: araaP; TIGR00837 813016693 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 813016694 aromatic amino acid transport protein; Region: araaP; TIGR00837 813016695 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 813016696 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 813016697 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 813016698 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 813016699 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 813016700 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 813016701 CoA-ligase; Region: Ligase_CoA; pfam00549 813016702 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 813016703 CoA binding domain; Region: CoA_binding; smart00881 813016704 CoA-ligase; Region: Ligase_CoA; pfam00549 813016705 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 813016706 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 813016707 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 813016708 protein binding site [polypeptide binding]; other site 813016709 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 813016710 protein binding site [polypeptide binding]; other site 813016711 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 813016712 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 813016713 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813016714 Peptidase M16C associated; Region: M16C_assoc; pfam08367 813016715 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813016716 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 813016717 RmuC family; Region: RmuC; pfam02646 813016718 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 813016719 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 813016720 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 813016721 ATP cone domain; Region: ATP-cone; pfam03477 813016722 ATP cone domain; Region: ATP-cone; pfam03477 813016723 Class I ribonucleotide reductase; Region: RNR_I; cd01679 813016724 active site 813016725 dimer interface [polypeptide binding]; other site 813016726 catalytic residues [active] 813016727 effector binding site; other site 813016728 R2 peptide binding site; other site 813016729 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 813016730 dimer interface [polypeptide binding]; other site 813016731 putative radical transfer pathway; other site 813016732 diiron center [ion binding]; other site 813016733 tyrosyl radical; other site 813016734 Putative methyltransferase; Region: Methyltransf_4; pfam02390 813016735 Methyltransferase domain; Region: Methyltransf_18; pfam12847 813016736 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 813016737 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 813016738 FAD binding domain; Region: FAD_binding_4; pfam01565 813016739 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 813016740 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 813016741 putative RNA binding site [nucleotide binding]; other site 813016742 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 813016743 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 813016744 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 813016745 Ribosomal protein L35 [Translation, ribosomal structure and biogenesis]; Region: RpmI; COG0291 813016746 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 813016747 23S rRNA binding site [nucleotide binding]; other site 813016748 L21 binding site [polypeptide binding]; other site 813016749 L13 binding site [polypeptide binding]; other site 813016750 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 813016751 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 813016752 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 813016753 motif 1; other site 813016754 dimer interface [polypeptide binding]; other site 813016755 active site 813016756 motif 2; other site 813016757 motif 3; other site 813016758 Predicted permeases [General function prediction only]; Region: COG0795 813016759 Predicted permeases [General function prediction only]; Region: COG0795 813016760 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 813016761 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 813016762 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 813016763 Ligand Binding Site [chemical binding]; other site 813016764 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 813016765 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 813016766 RNase E interface [polypeptide binding]; other site 813016767 trimer interface [polypeptide binding]; other site 813016768 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 813016769 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 813016770 RNase E interface [polypeptide binding]; other site 813016771 trimer interface [polypeptide binding]; other site 813016772 active site 813016773 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 813016774 putative nucleic acid binding region [nucleotide binding]; other site 813016775 G-X-X-G motif; other site 813016776 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 813016777 RNA binding site [nucleotide binding]; other site 813016778 domain interface; other site 813016779 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 813016780 16S/18S rRNA binding site [nucleotide binding]; other site 813016781 S13e-L30e interaction site [polypeptide binding]; other site 813016782 25S rRNA binding site [nucleotide binding]; other site 813016783 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 813016784 nucleoside/Zn binding site; other site 813016785 dimer interface [polypeptide binding]; other site 813016786 catalytic motif [active] 813016787 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813016788 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813016789 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813016790 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813016791 methionine aminopeptidase; Provisional; Region: PRK12318 813016792 SEC-C motif; Region: SEC-C; pfam02810 813016793 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 813016794 active site 813016795 MarC family integral membrane protein; Region: MarC; pfam01914 813016796 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 813016797 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 813016798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813016799 dimer interface [polypeptide binding]; other site 813016800 conserved gate region; other site 813016801 putative PBP binding loops; other site 813016802 ABC-ATPase subunit interface; other site 813016803 NMT1/THI5 like; Region: NMT1; pfam09084 813016804 fumarate hydratase, class II; Region: fumC_II; TIGR00979 813016805 Class II fumarases; Region: Fumarase_classII; cd01362 813016806 active site 813016807 tetramer interface [polypeptide binding]; other site 813016808 high affinity sulphate transporter 1; Region: sulP; TIGR00815 813016809 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 813016810 Sulfate transporter family; Region: Sulfate_transp; pfam00916 813016811 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 813016812 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 813016813 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 813016814 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 813016815 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 813016816 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 813016817 active site triad [active] 813016818 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 813016819 LytB protein; Region: LYTB; pfam02401 813016820 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 813016821 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 813016822 binding surface 813016823 TPR motif; other site 813016824 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 813016825 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 813016826 active site 813016827 DNA binding site [nucleotide binding] 813016828 Int/Topo IB signature motif; other site 813016829 glycogen branching enzyme; Provisional; Region: PRK05402 813016830 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 813016831 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 813016832 active site 813016833 catalytic site [active] 813016834 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 813016835 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 813016836 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813016837 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813016838 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813016839 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813016840 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813016841 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813016842 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813016843 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813016844 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813016845 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813016846 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813016847 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813016848 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813016849 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813016850 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813016851 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813016852 Uncharacterized conserved protein [Function unknown]; Region: COG2155 813016853 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 813016854 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 813016855 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 813016856 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 813016857 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 813016858 GatB domain; Region: GatB_Yqey; pfam02637 813016859 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 813016860 ribonuclease HIII; Region: rnhC; TIGR00716 813016861 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 813016862 RNA/DNA hybrid binding site [nucleotide binding]; other site 813016863 active site 813016864 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 813016865 Helix-turn-helix domain; Region: HTH_25; pfam13413 813016866 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906 813016867 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 813016868 putative acyl-acceptor binding pocket; other site 813016869 Uncharacterized conserved protein [Function unknown]; Region: COG1624 813016870 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 813016871 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 813016872 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 813016873 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 813016874 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 813016875 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 813016876 putative active site [active] 813016877 PhoH-like protein; Region: PhoH; pfam02562 813016878 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 813016879 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 813016880 HIGH motif; other site 813016881 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 813016882 active site 813016883 KMSKS motif; other site 813016884 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 813016885 tRNA binding surface [nucleotide binding]; other site 813016886 anticodon binding site; other site 813016887 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 813016888 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 813016889 Catalytic site [active] 813016890 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 813016891 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 813016892 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 813016893 peptide chain release factor 1; Validated; Region: prfA; PRK00591 813016894 PCRF domain; Region: PCRF; pfam03462 813016895 RF-1 domain; Region: RF-1; pfam00472 813016896 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 813016897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813016898 S-adenosylmethionine binding site [chemical binding]; other site 813016899 signal recognition particle protein; Provisional; Region: PRK10867 813016900 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 813016901 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 813016902 P loop; other site 813016903 GTP binding site [chemical binding]; other site 813016904 Signal peptide binding domain; Region: SRP_SPB; pfam02978 813016905 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 813016906 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 813016907 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 813016908 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 813016909 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 813016910 RNA/DNA hybrid binding site [nucleotide binding]; other site 813016911 active site 813016912 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 813016913 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 813016914 catalytic site [active] 813016915 G-X2-G-X-G-K; other site 813016916 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 813016917 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 813016918 active site 813016919 HIGH motif; other site 813016920 KMSKS motif; other site 813016921 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 813016922 tRNA binding surface [nucleotide binding]; other site 813016923 anticodon binding site; other site 813016924 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 813016925 AAA domain; Region: AAA_30; pfam13604 813016926 Family description; Region: UvrD_C_2; pfam13538 813016927 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 813016928 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 813016929 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 813016930 conserved cys residue [active] 813016931 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 813016932 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 813016933 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 813016934 trimer interface [polypeptide binding]; other site 813016935 active site 813016936 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 813016937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813016938 Walker A motif; other site 813016939 ATP binding site [chemical binding]; other site 813016940 Walker B motif; other site 813016941 arginine finger; other site 813016942 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 813016943 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813016944 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 813016945 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 813016946 dimer interface [polypeptide binding]; other site 813016947 ssDNA binding site [nucleotide binding]; other site 813016948 tetramer (dimer of dimers) interface [polypeptide binding]; other site 813016949 multifunctional aminopeptidase A; Provisional; Region: PRK00913 813016950 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 813016951 interface (dimer of trimers) [polypeptide binding]; other site 813016952 Substrate-binding/catalytic site; other site 813016953 Zn-binding sites [ion binding]; other site 813016954 hypothetical protein; Provisional; Region: PRK05907 813016955 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 813016956 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813016957 FeS/SAM binding site; other site 813016958 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 813016959 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 813016960 TPP-binding site [chemical binding]; other site 813016961 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 813016962 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 813016963 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813016964 E3 interaction surface; other site 813016965 lipoyl attachment site [posttranslational modification]; other site 813016966 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813016967 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 813016968 1-hydroxy-2-methyl-2-(e)-butenyl 4-diphosphate synthase [Lipid metabolism]; Region: gcpE; COG0821 813016969 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 813016970 ADP-ribose binding site [chemical binding]; other site 813016971 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 813016972 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 813016973 catalytic loop [active] 813016974 iron binding site [ion binding]; other site 813016975 type III secretion system protein; Validated; Region: PRK05910 813016976 FHIPEP family; Region: FHIPEP; pfam00771 813016977 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 813016978 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 813016979 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 813016980 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 813016981 DNA binding residues [nucleotide binding] 813016982 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 813016983 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 813016984 active site 813016985 HIGH motif; other site 813016986 dimer interface [polypeptide binding]; other site 813016987 KMSKS motif; other site 813016988 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813016989 RNA binding surface [nucleotide binding]; other site 813016990 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 813016991 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 813016992 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 813016993 GTP-binding protein LepA; Provisional; Region: PRK05433 813016994 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 813016995 G1 box; other site 813016996 putative GEF interaction site [polypeptide binding]; other site 813016997 GTP/Mg2+ binding site [chemical binding]; other site 813016998 Switch I region; other site 813016999 G2 box; other site 813017000 G3 box; other site 813017001 Switch II region; other site 813017002 G4 box; other site 813017003 G5 box; other site 813017004 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 813017005 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 813017006 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 813017007 ADP/ATP carrier protein family; Region: AAA; TIGR00769 813017008 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 813017009 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 813017010 intersubunit interface [polypeptide binding]; other site 813017011 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 813017012 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 813017013 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813017014 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813017015 ABC-ATPase subunit interface; other site 813017016 dimer interface [polypeptide binding]; other site 813017017 putative PBP binding regions; other site 813017018 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 813017019 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 813017020 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813017021 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813017022 ABC-ATPase subunit interface; other site 813017023 dimer interface [polypeptide binding]; other site 813017024 putative PBP binding regions; other site 813017025 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 813017026 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 813017027 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 813017028 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 813017029 RIP metalloprotease RseP; Region: TIGR00054 813017030 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 813017031 active site 813017032 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 813017033 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 813017034 putative substrate binding region [chemical binding]; other site 813017035 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 813017036 Putative serine esterase (DUF676); Region: DUF676; pfam05057 813017037 recF protein; Region: recf; TIGR00611 813017038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813017039 Walker A/P-loop; other site 813017040 ATP binding site [chemical binding]; other site 813017041 Q-loop/lid; other site 813017042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813017043 ABC transporter signature motif; other site 813017044 Walker B; other site 813017045 DNA polymerase III subunit beta; Validated; Region: PRK05643 813017046 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 813017047 putative DNA binding surface [nucleotide binding]; other site 813017048 dimer interface [polypeptide binding]; other site 813017049 beta-clamp/clamp loader binding surface; other site 813017050 beta-clamp/translesion DNA polymerase binding surface; other site 813017051 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 813017052 SmpB-tmRNA interface; other site 813017053 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 813017054 ApbE family; Region: ApbE; pfam02424 813017055 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 813017056 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 813017057 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 813017058 homodimer interface [polypeptide binding]; other site 813017059 NADP binding site [chemical binding]; other site 813017060 substrate binding site [chemical binding]; other site 813017061 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813017062 PLD-like domain; Region: PLDc_2; pfam13091 813017063 putative active site [active] 813017064 catalytic site [active] 813017065 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813017066 PLD-like domain; Region: PLDc_2; pfam13091 813017067 putative active site [active] 813017068 catalytic site [active] 813017069 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 813017070 4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446 813017071 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813017072 HrpJ-like domain; Region: HrpJ; cl15454 813017073 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 813017074 FHIPEP family; Region: FHIPEP; pfam00771 813017075 GTP-binding protein YchF; Reviewed; Region: PRK09601 813017076 YchF GTPase; Region: YchF; cd01900 813017077 G1 box; other site 813017078 GTP/Mg2+ binding site [chemical binding]; other site 813017079 Switch I region; other site 813017080 G2 box; other site 813017081 Switch II region; other site 813017082 G3 box; other site 813017083 G4 box; other site 813017084 G5 box; other site 813017085 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 813017086 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 813017087 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 813017088 active site 813017089 Riboflavin kinase; Region: Flavokinase; smart00904 813017090 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 813017091 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 813017092 RNA binding site [nucleotide binding]; other site 813017093 active site 813017094 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 813017095 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 813017096 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 813017097 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 813017098 G1 box; other site 813017099 putative GEF interaction site [polypeptide binding]; other site 813017100 GTP/Mg2+ binding site [chemical binding]; other site 813017101 Switch I region; other site 813017102 G2 box; other site 813017103 G3 box; other site 813017104 Switch II region; other site 813017105 G4 box; other site 813017106 G5 box; other site 813017107 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 813017108 Translation-initiation factor 2; Region: IF-2; pfam11987 813017109 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 813017110 transcription termination factor NusA; Region: NusA; TIGR01953 813017111 NusA N-terminal domain; Region: NusA_N; pfam08529 813017112 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 813017113 RNA binding site [nucleotide binding]; other site 813017114 homodimer interface [polypeptide binding]; other site 813017115 NusA-like KH domain; Region: KH_5; pfam13184 813017116 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 813017117 G-X-X-G motif; other site 813017118 ribosomal protein S1; Region: rpsA; TIGR00717 813017119 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 813017120 RNA binding site [nucleotide binding]; other site 813017121 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 813017122 RNA binding site [nucleotide binding]; other site 813017123 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813017124 RNA binding site [nucleotide binding]; other site 813017125 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813017126 RNA binding site [nucleotide binding]; other site 813017127 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 813017128 RNA binding site [nucleotide binding]; other site 813017129 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 813017130 RNA binding site [nucleotide binding]; other site 813017131 domain interface; other site 813017132 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 813017133 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 813017134 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 813017135 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 813017136 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 813017137 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 813017138 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 813017139 active site 813017140 motif I; other site 813017141 motif II; other site 813017142 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 813017143 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 813017144 NAD binding site [chemical binding]; other site 813017145 homotetramer interface [polypeptide binding]; other site 813017146 homodimer interface [polypeptide binding]; other site 813017147 substrate binding site [chemical binding]; other site 813017148 active site 813017149 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 813017150 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813017151 RNA binding surface [nucleotide binding]; other site 813017152 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 813017153 active site 813017154 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 813017155 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 813017156 minor groove reading motif; other site 813017157 helix-hairpin-helix signature motif; other site 813017158 substrate binding pocket [chemical binding]; other site 813017159 active site 813017160 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 813017161 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 813017162 DNA binding and oxoG recognition site [nucleotide binding] 813017163 Uncharacterized conserved protein [Function unknown]; Region: COG0327 813017164 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 813017165 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 813017166 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 813017167 ring oligomerisation interface [polypeptide binding]; other site 813017168 ATP/Mg binding site [chemical binding]; other site 813017169 stacking interactions; other site 813017170 hinge regions; other site 813017171 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 813017172 oligomerisation interface [polypeptide binding]; other site 813017173 mobile loop; other site 813017174 roof hairpin; other site 813017175 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 813017176 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 813017177 active site 813017178 Zn binding site [ion binding]; other site 813017179 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 813017180 Clp amino terminal domain; Region: Clp_N; pfam02861 813017181 Clp amino terminal domain; Region: Clp_N; pfam02861 813017182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813017183 Walker A motif; other site 813017184 ATP binding site [chemical binding]; other site 813017185 Walker B motif; other site 813017186 arginine finger; other site 813017187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813017188 Walker A motif; other site 813017189 ATP binding site [chemical binding]; other site 813017190 Walker B motif; other site 813017191 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 813017192 Uncharacterized conserved protein [Function unknown]; Region: COG2912 813017193 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 813017194 IncA protein; Region: IncA; pfam04156 813017195 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 813017196 elongation factor P; Provisional; Region: PRK12426 813017197 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813017198 RNA binding site [nucleotide binding]; other site 813017199 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 813017200 RNA binding site [nucleotide binding]; other site 813017201 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 813017202 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 813017203 carboxyltransferase (CT) interaction site; other site 813017204 biotinylation site [posttranslational modification]; other site 813017205 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 813017206 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 813017207 ATP-grasp domain; Region: ATP-grasp_4; cl17255 813017208 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 813017209 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 813017210 23S rRNA interface [nucleotide binding]; other site 813017211 L3 interface [polypeptide binding]; other site 813017212 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 813017213 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 813017214 NlpC/P60 family; Region: NLPC_P60; cl17555 813017215 adenylate kinase; Reviewed; Region: adk; PRK00279 813017216 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 813017217 AMP-binding site [chemical binding]; other site 813017218 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 813017219 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 813017220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813017221 dimer interface [polypeptide binding]; other site 813017222 conserved gate region; other site 813017223 putative PBP binding loops; other site 813017224 ABC-ATPase subunit interface; other site 813017225 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 813017226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813017227 Walker A/P-loop; other site 813017228 ATP binding site [chemical binding]; other site 813017229 Q-loop/lid; other site 813017230 ABC transporter signature motif; other site 813017231 Walker B; other site 813017232 D-loop; other site 813017233 H-loop/switch region; other site 813017234 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 813017235 Methyltransferase domain; Region: Methyltransf_23; pfam13489 813017236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813017237 S-adenosylmethionine binding site [chemical binding]; other site 813017238 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 813017239 Serine hydrolase (FSH1); Region: FSH1; pfam03959 813017240 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 813017241 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 813017242 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 813017243 active site 813017244 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 813017245 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 813017246 conserved hypothetical integral membrane protein; Region: TIGR00697 813017247 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 813017248 SEC-C motif; Region: SEC-C; pfam02810 813017249 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 813017250 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813017251 active site 813017252 ATP binding site [chemical binding]; other site 813017253 substrate binding site [chemical binding]; other site 813017254 activation loop (A-loop); other site 813017255 Uncharacterized conserved protein [Function unknown]; Region: COG1262 813017256 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 813017257 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 813017258 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 813017259 nucleotide binding pocket [chemical binding]; other site 813017260 K-X-D-G motif; other site 813017261 catalytic site [active] 813017262 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 813017263 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 813017264 Helix-hairpin-helix motif; Region: HHH; pfam00633 813017265 helix-hairpin-helix signature motif; other site 813017266 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 813017267 Dimer interface [polypeptide binding]; other site 813017268 BRCT sequence motif; other site 813017269 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 813017270 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 813017271 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 813017272 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 813017273 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 813017274 FtsX-like permease family; Region: FtsX; pfam02687 813017275 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 813017276 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 813017277 Walker A/P-loop; other site 813017278 ATP binding site [chemical binding]; other site 813017279 Q-loop/lid; other site 813017280 ABC transporter signature motif; other site 813017281 Walker B; other site 813017282 D-loop; other site 813017283 H-loop/switch region; other site 813017284 membrane-attack complex / perforin; Region: MACPF; smart00457 813017285 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 813017286 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813017287 PLD-like domain; Region: PLDc_2; pfam13091 813017288 putative active site [active] 813017289 catalytic site [active] 813017290 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813017291 PLD-like domain; Region: PLDc_2; pfam13091 813017292 putative active site [active] 813017293 catalytic site [active] 813017294 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813017295 PLD-like domain; Region: PLDc_2; pfam13091 813017296 putative active site [active] 813017297 catalytic site [active] 813017298 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813017299 PLD-like domain; Region: PLDc_2; pfam13091 813017300 putative active site [active] 813017301 catalytic site [active] 813017302 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813017303 PLD-like domain; Region: PLDc_2; pfam13091 813017304 putative active site [active] 813017305 catalytic site [active] 813017306 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813017307 PLD-like domain; Region: PLDc_2; pfam13091 813017308 putative active site [active] 813017309 catalytic site [active] 813017310 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813017311 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 813017312 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 813017313 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 813017314 trp operon repressor, proteobacterial; Region: TrpR; TIGR01321 813017315 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 813017316 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 813017317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813017318 catalytic residue [active] 813017319 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 813017320 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 813017321 substrate binding site [chemical binding]; other site 813017322 active site 813017323 catalytic residues [active] 813017324 heterodimer interface [polypeptide binding]; other site 813017325 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 813017326 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 813017327 peptide binding site [polypeptide binding]; other site 813017328 putative disulfide oxidoreductase; Provisional; Region: PRK00611 813017329 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 813017330 putative active site [active] 813017331 redox center [active] 813017332 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 813017333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813017334 Walker A/P-loop; other site 813017335 ATP binding site [chemical binding]; other site 813017336 Q-loop/lid; other site 813017337 ABC transporter signature motif; other site 813017338 Walker B; other site 813017339 D-loop; other site 813017340 H-loop/switch region; other site 813017341 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 813017342 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 813017343 Ligand binding site; other site 813017344 oligomer interface; other site 813017345 CTP synthetase; Validated; Region: pyrG; PRK05380 813017346 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 813017347 Catalytic site [active] 813017348 active site 813017349 UTP binding site [chemical binding]; other site 813017350 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 813017351 active site 813017352 putative oxyanion hole; other site 813017353 catalytic triad [active] 813017354 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 813017355 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 813017356 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 813017357 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 813017358 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 813017359 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 813017360 putative active site [active] 813017361 DNA polymerase III subunit delta'; Validated; Region: PRK05917 813017362 DNA polymerase III subunit delta'; Validated; Region: PRK08485 813017363 thymidylate kinase; Validated; Region: tmk; PRK00698 813017364 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 813017365 TMP-binding site; other site 813017366 ATP-binding site [chemical binding]; other site 813017367 DNA gyrase, A subunit; Region: gyrA; TIGR01063 813017368 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 813017369 CAP-like domain; other site 813017370 active site 813017371 primary dimer interface [polypeptide binding]; other site 813017372 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813017373 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813017374 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813017375 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813017376 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813017377 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813017378 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 813017379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813017380 ATP binding site [chemical binding]; other site 813017381 Mg2+ binding site [ion binding]; other site 813017382 G-X-G motif; other site 813017383 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 813017384 anchoring element; other site 813017385 dimer interface [polypeptide binding]; other site 813017386 ATP binding site [chemical binding]; other site 813017387 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 813017388 active site 813017389 putative metal-binding site [ion binding]; other site 813017390 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 813017391 Protein of unknown function (DUF721); Region: DUF721; pfam05258 813017392 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 813017393 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 813017394 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 813017395 MgtE intracellular N domain; Region: MgtE_N; pfam03448 813017396 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 813017397 Divalent cation transporter; Region: MgtE; pfam01769 813017398 UGMP family protein; Validated; Region: PRK09604 813017399 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 813017400 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 813017401 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 813017402 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 813017403 peptide binding site [polypeptide binding]; other site 813017404 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 813017405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813017406 dimer interface [polypeptide binding]; other site 813017407 conserved gate region; other site 813017408 putative PBP binding loops; other site 813017409 ABC-ATPase subunit interface; other site 813017410 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 813017411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813017412 dimer interface [polypeptide binding]; other site 813017413 conserved gate region; other site 813017414 putative PBP binding loops; other site 813017415 ABC-ATPase subunit interface; other site 813017416 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813017417 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 813017418 Walker A/P-loop; other site 813017419 ATP binding site [chemical binding]; other site 813017420 Q-loop/lid; other site 813017421 ABC transporter signature motif; other site 813017422 Walker B; other site 813017423 D-loop; other site 813017424 H-loop/switch region; other site 813017425 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 813017426 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 813017427 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813017428 Walker A/P-loop; other site 813017429 ATP binding site [chemical binding]; other site 813017430 Q-loop/lid; other site 813017431 ABC transporter signature motif; other site 813017432 Walker B; other site 813017433 D-loop; other site 813017434 H-loop/switch region; other site 813017435 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813017436 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 813017437 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 813017438 transmembrane helices; other site 813017439 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 813017440 active site 813017441 ADP/pyrophosphate binding site [chemical binding]; other site 813017442 dimerization interface [polypeptide binding]; other site 813017443 allosteric effector site; other site 813017444 fructose-1,6-bisphosphate binding site; other site 813017445 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 813017446 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 813017447 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 813017448 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 813017449 active site 813017450 ADP/pyrophosphate binding site [chemical binding]; other site 813017451 dimerization interface [polypeptide binding]; other site 813017452 allosteric effector site; other site 813017453 fructose-1,6-bisphosphate binding site; other site 813017454 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 813017455 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 813017456 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 813017457 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 813017458 HIGH motif; other site 813017459 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 813017460 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 813017461 active site 813017462 KMSKS motif; other site 813017463 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 813017464 tRNA binding surface [nucleotide binding]; other site 813017465 Putative transcriptional regulator [Transcription]; Region: COG1678 813017466 Uncharacterized conserved protein [Function unknown]; Region: COG1259 813017467 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 813017468 tetramer (dimer of dimers) interface [polypeptide binding]; other site 813017469 active site 813017470 dimer interface [polypeptide binding]; other site 813017471 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 813017472 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 813017473 putative active site; other site 813017474 catalytic residue [active] 813017475 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 813017476 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 813017477 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 813017478 Ligand Binding Site [chemical binding]; other site 813017479 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 813017480 prenyltransferase; Reviewed; Region: ubiA; PRK12876 813017481 UbiA prenyltransferase family; Region: UbiA; pfam01040 813017482 aromatic acid decarboxylase; Validated; Region: PRK05920 813017483 Flavoprotein; Region: Flavoprotein; pfam02441 813017484 Uncharacterized conserved protein [Function unknown]; Region: COG1284 813017485 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 813017486 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813017487 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 813017488 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 813017489 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 813017490 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 813017491 Na2 binding site [ion binding]; other site 813017492 putative substrate binding site 1 [chemical binding]; other site 813017493 Na binding site 1 [ion binding]; other site 813017494 putative substrate binding site 2 [chemical binding]; other site 813017495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813017496 putative substrate translocation pore; other site 813017497 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 813017498 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 813017499 ligand binding site [chemical binding]; other site 813017500 flexible hinge region; other site 813017501 acyl carrier protein; Provisional; Region: acpP; PRK00982 813017502 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 813017503 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 813017504 NAD(P) binding site [chemical binding]; other site 813017505 homotetramer interface [polypeptide binding]; other site 813017506 homodimer interface [polypeptide binding]; other site 813017507 active site 813017508 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 813017509 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 813017510 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 813017511 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 813017512 dimer interface [polypeptide binding]; other site 813017513 active site 813017514 CoA binding pocket [chemical binding]; other site 813017515 recombination protein RecR; Region: recR; TIGR00615 813017516 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 813017517 putative active site [active] 813017518 putative metal-binding site [ion binding]; other site 813017519 tetramer interface [polypeptide binding]; other site 813017520 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 813017521 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813017522 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813017523 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813017524 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813017525 Surface antigen; Region: Bac_surface_Ag; pfam01103 813017526 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 813017527 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 813017528 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 813017529 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 813017530 trimer interface [polypeptide binding]; other site 813017531 active site 813017532 UDP-GlcNAc binding site [chemical binding]; other site 813017533 lipid binding site [chemical binding]; lipid-binding site 813017534 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 813017535 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 813017536 tetramer interface [polypeptide binding]; other site 813017537 TPP-binding site [chemical binding]; other site 813017538 heterodimer interface [polypeptide binding]; other site 813017539 phosphorylation loop region [posttranslational modification] 813017540 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 813017541 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 813017542 alpha subunit interface [polypeptide binding]; other site 813017543 TPP binding site [chemical binding]; other site 813017544 heterodimer interface [polypeptide binding]; other site 813017545 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813017546 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 813017547 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813017548 E3 interaction surface; other site 813017549 lipoyl attachment site [posttranslational modification]; other site 813017550 e3 binding domain; Region: E3_binding; pfam02817 813017551 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813017552 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 813017553 homodimer interface [polypeptide binding]; other site 813017554 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 813017555 active site pocket [active] 813017556 chromosomal replication initiation protein; Provisional; Region: PRK12422 813017557 DnaA N-terminal domain; Region: DnaA_N; pfam11638 813017558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813017559 Walker A motif; other site 813017560 ATP binding site [chemical binding]; other site 813017561 Walker B motif; other site 813017562 arginine finger; other site 813017563 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 813017564 DnaA box-binding interface [nucleotide binding]; other site 813017565 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 813017566 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 813017567 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 813017568 CAAX protease self-immunity; Region: Abi; pfam02517 813017569 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 813017570 homodimer interface [polypeptide binding]; other site 813017571 metal binding site [ion binding]; metal-binding site 813017572 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 813017573 Domain of unknown function DUF21; Region: DUF21; pfam01595 813017574 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813017575 Transporter associated domain; Region: CorC_HlyC; smart01091 813017576 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 813017577 Domain of unknown function DUF21; Region: DUF21; pfam01595 813017578 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813017579 Transporter associated domain; Region: CorC_HlyC; smart01091 813017580 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 813017581 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 813017582 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813017583 catalytic residue [active] 813017584 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 813017585 Protein phosphatase 2C; Region: PP2C; pfam00481 813017586 active site 813017587 Uncharacterized conserved protein [Function unknown]; Region: COG5465 813017588 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 813017589 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 813017590 active site 813017591 catalytic site [active] 813017592 substrate binding site [chemical binding]; other site 813017593 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 813017594 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 813017595 nucleosidase; Provisional; Region: PRK05634 813017596 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 813017597 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 813017598 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 813017599 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 813017600 active site 813017601 metal binding site [ion binding]; metal-binding site 813017602 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 813017603 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 813017604 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813017605 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813017606 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 813017607 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 813017608 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 813017609 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 813017610 MraW methylase family; Region: Methyltransf_5; pfam01795 813017611 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813017612 TPR motif; other site 813017613 binding surface 813017614 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 813017615 DnaA N-terminal domain; Region: DnaA_N; pfam11638 813017616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813017617 Walker A motif; other site 813017618 ATP binding site [chemical binding]; other site 813017619 Walker B motif; other site 813017620 arginine finger; other site 813017621 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 813017622 DnaA box-binding interface [nucleotide binding]; other site 813017623 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 813017624 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 813017625 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 813017626 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 813017627 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 813017628 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 813017629 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 813017630 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 813017631 lipoyl attachment site [posttranslational modification]; other site 813017632 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 813017633 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 813017634 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813017635 putative active site [active] 813017636 catalytic site [active] 813017637 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813017638 putative active site [active] 813017639 catalytic site [active] 813017640 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 813017641 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 813017642 Clp amino terminal domain; Region: Clp_N; pfam02861 813017643 Clp amino terminal domain; Region: Clp_N; pfam02861 813017644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813017645 Walker A motif; other site 813017646 ATP binding site [chemical binding]; other site 813017647 Walker B motif; other site 813017648 arginine finger; other site 813017649 UvrB/uvrC motif; Region: UVR; pfam02151 813017650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813017651 Walker A motif; other site 813017652 ATP binding site [chemical binding]; other site 813017653 Walker B motif; other site 813017654 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 813017655 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 813017656 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 813017657 Ligand Binding Site [chemical binding]; other site 813017658 Helix-turn-helix domain; Region: HTH_17; pfam12728 813017659 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 813017660 active site 813017661 phosphorylation site [posttranslational modification] 813017662 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 813017663 active site 813017664 phosphorylation site [posttranslational modification] 813017665 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 813017666 trimer interface [polypeptide binding]; other site 813017667 active site 813017668 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 813017669 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 813017670 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 813017671 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 813017672 active site 813017673 substrate binding site [chemical binding]; other site 813017674 metal binding site [ion binding]; metal-binding site 813017675 ribonuclease III; Reviewed; Region: rnc; PRK00102 813017676 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 813017677 dimerization interface [polypeptide binding]; other site 813017678 active site 813017679 metal binding site [ion binding]; metal-binding site 813017680 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 813017681 dsRNA binding site [nucleotide binding]; other site 813017682 DNA repair protein RadA; Provisional; Region: PRK11823 813017683 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 813017684 Walker A motif/ATP binding site; other site 813017685 ATP binding site [chemical binding]; other site 813017686 Walker B motif; other site 813017687 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 813017688 porphobilinogen deaminase; Provisional; Region: PRK01066 813017689 Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379 813017690 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 813017691 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813017692 active site 813017693 ATP binding site [chemical binding]; other site 813017694 substrate binding site [chemical binding]; other site 813017695 activation loop (A-loop); other site 813017696 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 813017697 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 813017698 HIGH motif; other site 813017699 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 813017700 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 813017701 active site 813017702 KMSKS motif; other site 813017703 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 813017704 tRNA binding surface [nucleotide binding]; other site 813017705 anticodon binding site; other site 813017706 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 813017707 V-type ATP synthase subunit K; Provisional; Region: PRK09621 813017708 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 813017709 V-type ATP synthase subunit I; Validated; Region: PRK05771 813017710 Protein of unknown function (DUF1319); Region: DUF1319; pfam07028 813017711 V-type ATP synthase subunit D; Provisional; Region: PRK02195 813017712 V-type ATP synthase subunit B; Provisional; Region: PRK02118 813017713 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813017714 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 813017715 Walker A motif homologous position; other site 813017716 Walker B motif; other site 813017717 V-type ATP synthase subunit A; Provisional; Region: PRK04192 813017718 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813017719 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 813017720 Walker A motif/ATP binding site; other site 813017721 Walker B motif; other site 813017722 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 813017723 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 813017724 V-type ATP synthase subunit E; Provisional; Region: PRK01005 813017725 V-type ATP synthase subunit E; Provisional; Region: PRK01558 813017726 transaldolase-like protein; Provisional; Region: PTZ00411 813017727 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 813017728 active site 813017729 dimer interface [polypeptide binding]; other site 813017730 catalytic residue [active] 813017731 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 813017732 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 813017733 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 813017734 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 813017735 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 813017736 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 813017737 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 813017738 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 813017739 DNA binding site [nucleotide binding] 813017740 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 813017741 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 813017742 L11 interface [polypeptide binding]; other site 813017743 putative EF-Tu interaction site [polypeptide binding]; other site 813017744 putative EF-G interaction site [polypeptide binding]; other site 813017745 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 813017746 23S rRNA interface [nucleotide binding]; other site 813017747 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 813017748 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 813017749 mRNA/rRNA interface [nucleotide binding]; other site 813017750 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 813017751 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 813017752 putative thiostrepton binding site; other site 813017753 23S rRNA interface [nucleotide binding]; other site 813017754 L7/L12 interface [polypeptide binding]; other site 813017755 L25 interface [polypeptide binding]; other site 813017756 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 813017757 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 813017758 putative homodimer interface [polypeptide binding]; other site 813017759 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 813017760 heterodimer interface [polypeptide binding]; other site 813017761 homodimer interface [polypeptide binding]; other site 813017762 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 813017763 elongation factor Tu; Reviewed; Region: PRK12735 813017764 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 813017765 G1 box; other site 813017766 GEF interaction site [polypeptide binding]; other site 813017767 GTP/Mg2+ binding site [chemical binding]; other site 813017768 Switch I region; other site 813017769 G2 box; other site 813017770 G3 box; other site 813017771 Switch II region; other site 813017772 G4 box; other site 813017773 G5 box; other site 813017774 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 813017775 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 813017776 Antibiotic Binding Site [chemical binding]; other site 813017777 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 813017778 rRNA binding site [nucleotide binding]; other site 813017779 predicted 30S ribosome binding site; other site 813017780 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 813017781 Protein of unknown function (DUF687); Region: DUF687; pfam05095 813017782 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 813017783 active site 813017784 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 813017785 triosephosphate isomerase; Provisional; Region: PRK14565 813017786 substrate binding site [chemical binding]; other site 813017787 dimer interface [polypeptide binding]; other site 813017788 catalytic triad [active] 813017789 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 813017790 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 813017791 generic binding surface II; other site 813017792 generic binding surface I; other site 813017793 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 813017794 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 813017795 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 813017796 TPP-binding site [chemical binding]; other site 813017797 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 813017798 PYR/PP interface [polypeptide binding]; other site 813017799 dimer interface [polypeptide binding]; other site 813017800 TPP binding site [chemical binding]; other site 813017801 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813017802 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 813017803 pyruvate kinase; Region: pyruv_kin; TIGR01064 813017804 domain interfaces; other site 813017805 active site 813017806 excinuclease ABC subunit A; Provisional; Region: PRK00635 813017807 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 813017808 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 813017809 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 813017810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813017811 Walker A/P-loop; other site 813017812 ATP binding site [chemical binding]; other site 813017813 Q-loop/lid; other site 813017814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813017815 ABC transporter signature motif; other site 813017816 Walker B; other site 813017817 D-loop; other site 813017818 H-loop/switch region; other site 813017819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813017820 Walker A/P-loop; other site 813017821 ATP binding site [chemical binding]; other site 813017822 Q-loop/lid; other site 813017823 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813017824 Q-loop/lid; other site 813017825 ABC transporter signature motif; other site 813017826 Walker B; other site 813017827 D-loop; other site 813017828 H-loop/switch region; other site 813017829 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 813017830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813017831 Walker A motif; other site 813017832 ATP binding site [chemical binding]; other site 813017833 Walker B motif; other site 813017834 arginine finger; other site 813017835 hypothetical protein; Validated; Region: PRK00153 813017836 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 813017837 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 813017838 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 813017839 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 813017840 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 813017841 Competence protein; Region: Competence; pfam03772 813017842 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 813017843 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 813017844 tetramer interface [polypeptide binding]; other site 813017845 TPP-binding site [chemical binding]; other site 813017846 heterodimer interface [polypeptide binding]; other site 813017847 phosphorylation loop region [posttranslational modification] 813017848 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 813017849 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 813017850 alpha subunit interface [polypeptide binding]; other site 813017851 TPP binding site [chemical binding]; other site 813017852 heterodimer interface [polypeptide binding]; other site 813017853 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813017854 chaperone protein DnaJ; Provisional; Region: PRK14284 813017855 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 813017856 HSP70 interaction site [polypeptide binding]; other site 813017857 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 813017858 Zn binding sites [ion binding]; other site 813017859 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 813017860 dimer interface [polypeptide binding]; other site 813017861 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 813017862 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 813017863 Glycoprotease family; Region: Peptidase_M22; pfam00814 813017864 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 813017865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813017866 Walker A motif; other site 813017867 ATP binding site [chemical binding]; other site 813017868 Walker B motif; other site 813017869 arginine finger; other site 813017870 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 813017871 ribonuclease Z; Region: RNase_Z; TIGR02651 813017872 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 813017873 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 813017874 active site 813017875 Int/Topo IB signature motif; other site 813017876 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 813017877 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813017878 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813017879 ABC transporter; Region: ABC_tran_2; pfam12848 813017880 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813017881 Maf-like protein; Region: Maf; pfam02545 813017882 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 813017883 active site 813017884 dimer interface [polypeptide binding]; other site 813017885 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 813017886 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 813017887 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 813017888 active site 813017889 catalytic residues [active] 813017890 metal binding site [ion binding]; metal-binding site 813017891 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 813017892 dimethyladenosine transferase; Region: ksgA; TIGR00755 813017893 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 813017894 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 813017895 catalytic residues [active] 813017896 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 813017897 dihydrodipicolinate synthase; Region: dapA; TIGR00674 813017898 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 813017899 inhibitor site; inhibition site 813017900 active site 813017901 dimer interface [polypeptide binding]; other site 813017902 catalytic residue [active] 813017903 aspartate kinase; Provisional; Region: PRK05925 813017904 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 813017905 putative catalytic residues [active] 813017906 nucleotide binding site [chemical binding]; other site 813017907 aspartate binding site [chemical binding]; other site 813017908 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 813017909 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 813017910 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 813017911 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 813017912 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 813017913 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 813017914 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 813017915 hinge; other site 813017916 active site 813017917 shikimate kinase; Provisional; Region: PRK00625 813017918 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 813017919 ADP binding site [chemical binding]; other site 813017920 magnesium binding site [ion binding]; other site 813017921 putative shikimate binding site; other site 813017922 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 813017923 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 813017924 Tetramer interface [polypeptide binding]; other site 813017925 active site 813017926 FMN-binding site [chemical binding]; other site 813017927 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 813017928 active site 813017929 dimer interface [polypeptide binding]; other site 813017930 metal binding site [ion binding]; metal-binding site 813017931 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 813017932 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 813017933 active site 813017934 catalytic residue [active] 813017935 dimer interface [polypeptide binding]; other site 813017936 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 813017937 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 813017938 shikimate binding site; other site 813017939 NAD(P) binding site [chemical binding]; other site 813017940 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 813017941 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 813017942 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 813017943 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 813017944 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 813017945 malate dehydrogenase; Provisional; Region: PRK05442 813017946 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 813017947 NAD(P) binding site [chemical binding]; other site 813017948 dimer interface [polypeptide binding]; other site 813017949 malate binding site [chemical binding]; other site 813017950 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 813017951 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 813017952 active site 813017953 dimer interface [polypeptide binding]; other site 813017954 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 813017955 dimer interface [polypeptide binding]; other site 813017956 active site 813017957 GTPases [General function prediction only]; Region: HflX; COG2262 813017958 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 813017959 HflX GTPase family; Region: HflX; cd01878 813017960 G1 box; other site 813017961 GTP/Mg2+ binding site [chemical binding]; other site 813017962 Switch I region; other site 813017963 G2 box; other site 813017964 G3 box; other site 813017965 Switch II region; other site 813017966 G4 box; other site 813017967 G5 box; other site 813017968 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 813017969 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 813017970 substrate binding pocket [chemical binding]; other site 813017971 membrane-bound complex binding site; other site 813017972 hinge residues; other site 813017973 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 813017974 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 813017975 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 813017976 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 813017977 nucleotide binding site/active site [active] 813017978 Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286 813017979 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 813017980 hypothetical protein; Validated; Region: PRK00647 813017981 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 813017982 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 813017983 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 813017984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813017985 homodimer interface [polypeptide binding]; other site 813017986 catalytic residue [active] 813017987 ABC transporter substrate binding protein; Region: ABC_sub_bind; pfam04392 813017988 prolyl-tRNA synthetase; Provisional; Region: PRK09194 813017989 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 813017990 dimer interface [polypeptide binding]; other site 813017991 motif 1; other site 813017992 active site 813017993 motif 2; other site 813017994 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 813017995 putative deacylase active site [active] 813017996 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813017997 active site 813017998 motif 3; other site 813017999 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 813018000 anticodon binding site; other site 813018001 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 813018002 GrpE; Region: GrpE; pfam01025 813018003 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 813018004 dimer interface [polypeptide binding]; other site 813018005 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 813018006 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 813018007 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 813018008 nucleotide binding site [chemical binding]; other site 813018009 NEF interaction site [polypeptide binding]; other site 813018010 SBD interface [polypeptide binding]; other site 813018011 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 813018012 Exoribonuclease R [Transcription]; Region: VacB; COG0557 813018013 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 813018014 RNB domain; Region: RNB; pfam00773 813018015 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 813018016 Putative zinc ribbon domain; Region: DUF164; pfam02591 813018017 KpsF/GutQ family protein; Region: kpsF; TIGR00393 813018018 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 813018019 putative active site [active] 813018020 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 813018021 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 813018022 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813018023 E3 interaction surface; other site 813018024 lipoyl attachment site [posttranslational modification]; other site 813018025 e3 binding domain; Region: E3_binding; pfam02817 813018026 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813018027 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 813018028 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 813018029 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 813018030 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 813018031 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 813018032 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 813018033 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 813018034 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 813018035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813018036 S-adenosylmethionine binding site [chemical binding]; other site 813018037 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 813018038 Lumazine binding domain; Region: Lum_binding; pfam00677 813018039 Lumazine binding domain; Region: Lum_binding; pfam00677 813018040 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 813018041 ATP cone domain; Region: ATP-cone; pfam03477 813018042 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 813018043 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 813018044 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 813018045 amino acid carrier protein; Region: agcS; TIGR00835 813018046 poly(A) polymerase; Region: pcnB; TIGR01942 813018047 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 813018048 active site 813018049 NTP binding site [chemical binding]; other site 813018050 metal binding triad [ion binding]; metal-binding site 813018051 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 813018052 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 813018053 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 813018054 Predicted membrane protein [Function unknown]; Region: COG3952 813018055 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 813018056 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813018057 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813018058 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813018059 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813018060 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813018061 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 813018062 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 813018063 intersubunit interface [polypeptide binding]; other site 813018064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813018065 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 813018066 Walker A/P-loop; other site 813018067 ATP binding site [chemical binding]; other site 813018068 Q-loop/lid; other site 813018069 ABC transporter signature motif; other site 813018070 Walker B; other site 813018071 D-loop; other site 813018072 H-loop/switch region; other site 813018073 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813018074 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813018075 ABC-ATPase subunit interface; other site 813018076 dimer interface [polypeptide binding]; other site 813018077 putative PBP binding regions; other site 813018078 GTPase CgtA; Reviewed; Region: obgE; PRK12299 813018079 GTP1/OBG; Region: GTP1_OBG; pfam01018 813018080 Obg GTPase; Region: Obg; cd01898 813018081 G1 box; other site 813018082 GTP/Mg2+ binding site [chemical binding]; other site 813018083 Switch I region; other site 813018084 G2 box; other site 813018085 G3 box; other site 813018086 Switch II region; other site 813018087 G4 box; other site 813018088 G5 box; other site 813018089 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 813018090 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 813018091 Uncharacterized conserved protein [Function unknown]; Region: COG2928 813018092 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 813018093 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 813018094 FOG: CBS domain [General function prediction only]; Region: COG0517 813018095 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813018096 Transporter associated domain; Region: CorC_HlyC; smart01091 813018097 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 813018098 anti sigma factor interaction site; other site 813018099 regulatory phosphorylation site [posttranslational modification]; other site 813018100 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 813018101 hypothetical protein; Provisional; Region: PRK05926 813018102 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813018103 FeS/SAM binding site; other site 813018104 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 813018105 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 813018106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813018107 S-adenosylmethionine binding site [chemical binding]; other site 813018108 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 813018109 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 813018110 diaminopimelate epimerase; Region: DapF; TIGR00652 813018111 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 813018112 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 813018113 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 813018114 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 813018115 active site 813018116 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 813018117 homotrimer interaction site [polypeptide binding]; other site 813018118 zinc binding site [ion binding]; other site 813018119 CDP-binding sites; other site 813018120 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 813018121 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 813018122 FAD binding pocket [chemical binding]; other site 813018123 conserved FAD binding motif [chemical binding]; other site 813018124 phosphate binding motif [ion binding]; other site 813018125 beta-alpha-beta structure motif; other site 813018126 NAD binding pocket [chemical binding]; other site 813018127 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 813018128 elongation factor G; Reviewed; Region: PRK12739 813018129 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 813018130 G1 box; other site 813018131 putative GEF interaction site [polypeptide binding]; other site 813018132 GTP/Mg2+ binding site [chemical binding]; other site 813018133 Switch I region; other site 813018134 G2 box; other site 813018135 G3 box; other site 813018136 Switch II region; other site 813018137 G4 box; other site 813018138 G5 box; other site 813018139 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 813018140 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 813018141 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 813018142 30S ribosomal protein S7; Validated; Region: PRK05302 813018143 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 813018144 S17 interaction site [polypeptide binding]; other site 813018145 S8 interaction site; other site 813018146 16S rRNA interaction site [nucleotide binding]; other site 813018147 streptomycin interaction site [chemical binding]; other site 813018148 23S rRNA interaction site [nucleotide binding]; other site 813018149 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 813018150 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 813018151 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 813018152 protein binding site [polypeptide binding]; other site 813018153 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 813018154 Catalytic dyad [active] 813018155 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 813018156 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 813018157 Domain of unknown function DUF11; Region: DUF11; pfam01345 813018158 Domain of unknown function DUF11; Region: DUF11; pfam01345 813018159 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 813018160 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 813018161 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 813018162 HIGH motif; other site 813018163 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 813018164 active site 813018165 KMSKS motif; other site 813018166 Helix-turn-helix domain; Region: HTH_17; pfam12728 813018167 Helix-turn-helix domain; Region: HTH_17; pfam12728 813018168 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 813018169 DHH family; Region: DHH; pfam01368 813018170 DHHA1 domain; Region: DHHA1; pfam02272 813018171 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 813018172 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 813018173 Protein export membrane protein; Region: SecD_SecF; pfam02355 813018174 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 813018175 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 813018176 catalytic residue [active] 813018177 putative FPP diphosphate binding site; other site 813018178 putative FPP binding hydrophobic cleft; other site 813018179 dimer interface [polypeptide binding]; other site 813018180 putative IPP diphosphate binding site; other site 813018181 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 813018182 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 813018183 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 813018184 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 813018185 CMP-binding site; other site 813018186 The sites determining sugar specificity; other site 813018187 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 813018188 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 813018189 putative acyl-acceptor binding pocket; other site 813018190 arginine-tRNA ligase; Region: PLN02286 813018191 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 813018192 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 813018193 active site 813018194 HIGH motif; other site 813018195 KMSK motif region; other site 813018196 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813018197 tRNA binding surface [nucleotide binding]; other site 813018198 anticodon binding site; other site 813018199 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 813018200 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 813018201 hinge; other site 813018202 active site 813018203 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 813018204 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 813018205 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 813018206 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 813018207 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 813018208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 813018209 Coenzyme A binding pocket [chemical binding]; other site 813018210 PCRF domain; Region: PCRF; pfam03462 813018211 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 813018212 RF-1 domain; Region: RF-1; pfam00472 813018213 SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531 813018214 SWI complex, BAF60b domains; Region: SWIB; smart00151 813018215 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 813018216 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813018217 putative active site [active] 813018218 putative metal binding site [ion binding]; other site 813018219 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 813018220 substrate binding site; other site 813018221 dimer interface; other site 813018222 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 813018223 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 813018224 dimerization interface 3.5A [polypeptide binding]; other site 813018225 active site 813018226 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 813018227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 813018228 active site 813018229 motif I; other site 813018230 motif II; other site 813018231 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 813018232 PAS domain; Region: PAS; smart00091 813018233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 813018234 dimer interface [polypeptide binding]; other site 813018235 phosphorylation site [posttranslational modification] 813018236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813018237 ATP binding site [chemical binding]; other site 813018238 Mg2+ binding site [ion binding]; other site 813018239 G-X-G motif; other site 813018240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 813018241 Response regulator receiver domain; Region: Response_reg; pfam00072 813018242 active site 813018243 phosphorylation site [posttranslational modification] 813018244 intermolecular recognition site; other site 813018245 dimerization interface [polypeptide binding]; other site 813018246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813018247 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 813018248 Walker A motif; other site 813018249 ATP binding site [chemical binding]; other site 813018250 Walker B motif; other site 813018251 arginine finger; other site 813018252 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 813018253 Recombination protein O N terminal; Region: RecO_N; pfam11967 813018254 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 813018255 Recombination protein O C terminal; Region: RecO_C; pfam02565 813018256 Uncharacterized conserved protein [Function unknown]; Region: COG1723 813018257 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 813018258 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 813018259 putative tRNA-binding site [nucleotide binding]; other site 813018260 B3/4 domain; Region: B3_4; pfam03483 813018261 tRNA synthetase B5 domain; Region: B5; smart00874 813018262 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 813018263 dimer interface [polypeptide binding]; other site 813018264 motif 1; other site 813018265 motif 3; other site 813018266 motif 2; other site 813018267 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 813018268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813018269 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 813018270 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 813018271 DNA binding site [nucleotide binding] 813018272 active site 813018273 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 813018274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813018275 dimer interface [polypeptide binding]; other site 813018276 conserved gate region; other site 813018277 putative PBP binding loops; other site 813018278 ABC-ATPase subunit interface; other site 813018279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 813018280 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 813018281 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 813018282 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 813018283 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 813018284 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 813018285 putative active site [active] 813018286 putative metal binding site [ion binding]; other site 813018287 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813018288 binding surface 813018289 TPR motif; other site 813018290 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 813018291 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 813018292 C-terminal domain interface [polypeptide binding]; other site 813018293 active site 813018294 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 813018295 active site 813018296 N-terminal domain interface [polypeptide binding]; other site 813018297 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 813018298 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 813018299 substrate binding pocket [chemical binding]; other site 813018300 membrane-bound complex binding site; other site 813018301 hinge residues; other site 813018302 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 813018303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813018304 S-adenosylmethionine binding site [chemical binding]; other site 813018305 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 813018306 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813018307 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 813018308 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 813018309 ligand binding site; other site 813018310 oligomer interface; other site 813018311 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 813018312 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 813018313 N-terminal domain interface [polypeptide binding]; other site 813018314 sulfate 1 binding site; other site 813018315 transcription termination factor Rho; Region: rho; TIGR00767 813018316 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 813018317 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 813018318 RNA binding site [nucleotide binding]; other site 813018319 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 813018320 multimer interface [polypeptide binding]; other site 813018321 Walker A motif; other site 813018322 ATP binding site [chemical binding]; other site 813018323 Walker B motif; other site 813018324 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 813018325 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 813018326 CoA-binding site [chemical binding]; other site 813018327 ATP-binding [chemical binding]; other site 813018328 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 813018329 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 813018330 tandem repeat interface [polypeptide binding]; other site 813018331 oligomer interface [polypeptide binding]; other site 813018332 active site residues [active] 813018333 TLC ATP/ADP transporter; Region: TLC; pfam03219 813018334 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 813018335 replicative DNA helicase; Provisional; Region: PRK06321 813018336 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 813018337 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 813018338 Walker A motif; other site 813018339 ATP binding site [chemical binding]; other site 813018340 Walker B motif; other site 813018341 DNA binding loops [nucleotide binding] 813018342 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 813018343 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 813018344 RuvA N terminal domain; Region: RuvA_N; pfam01330 813018345 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 813018346 active site 813018347 putative DNA-binding cleft [nucleotide binding]; other site 813018348 dimer interface [polypeptide binding]; other site 813018349 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 813018350 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 813018351 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 813018352 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 813018353 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 813018354 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 813018355 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 813018356 alphaNTD - beta interaction site [polypeptide binding]; other site 813018357 alphaNTD homodimer interface [polypeptide binding]; other site 813018358 alphaNTD - beta' interaction site [polypeptide binding]; other site 813018359 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 813018360 30S ribosomal protein S11; Validated; Region: PRK05309 813018361 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 813018362 30S ribosomal protein S13; Region: bact_S13; TIGR03631 813018363 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 813018364 SecY translocase; Region: SecY; pfam00344 813018365 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 813018366 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 813018367 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 813018368 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 813018369 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 813018370 5S rRNA interface [nucleotide binding]; other site 813018371 23S rRNA interface [nucleotide binding]; other site 813018372 L5 interface [polypeptide binding]; other site 813018373 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 813018374 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 813018375 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 813018376 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 813018377 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 813018378 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 813018379 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 813018380 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 813018381 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 813018382 RNA binding site [nucleotide binding]; other site 813018383 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 813018384 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 813018385 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 813018386 23S rRNA interface [nucleotide binding]; other site 813018387 putative translocon interaction site; other site 813018388 signal recognition particle (SRP54) interaction site; other site 813018389 L23 interface [polypeptide binding]; other site 813018390 trigger factor interaction site; other site 813018391 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 813018392 23S rRNA interface [nucleotide binding]; other site 813018393 5S rRNA interface [nucleotide binding]; other site 813018394 putative antibiotic binding site [chemical binding]; other site 813018395 L25 interface [polypeptide binding]; other site 813018396 L27 interface [polypeptide binding]; other site 813018397 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 813018398 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 813018399 G-X-X-G motif; other site 813018400 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 813018401 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 813018402 putative translocon binding site; other site 813018403 protein-rRNA interface [nucleotide binding]; other site 813018404 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 813018405 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 813018406 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 813018407 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 813018408 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 813018409 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 813018410 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 813018411 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 813018412 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 813018413 putative active site [active] 813018414 substrate binding site [chemical binding]; other site 813018415 putative cosubstrate binding site; other site 813018416 catalytic site [active] 813018417 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 813018418 substrate binding site [chemical binding]; other site 813018419 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 813018420 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 813018421 active site 813018422 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 813018423 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 813018424 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 813018425 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 813018426 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 813018427 putative active site [active] 813018428 catalytic triad [active] 813018429 putative dimer interface [polypeptide binding]; other site 813018430 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 813018431 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 813018432 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 813018433 active site 813018434 catalytic site [active] 813018435 substrate binding site [chemical binding]; other site 813018436 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 813018437 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 813018438 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 813018439 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 813018440 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813018441 catalytic residues [active] 813018442 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 813018443 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 813018444 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 813018445 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 813018446 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 813018447 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 813018448 dimer interface [polypeptide binding]; other site 813018449 anticodon binding site; other site 813018450 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 813018451 homodimer interface [polypeptide binding]; other site 813018452 motif 1; other site 813018453 active site 813018454 motif 2; other site 813018455 GAD domain; Region: GAD; pfam02938 813018456 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813018457 active site 813018458 motif 3; other site 813018459 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 813018460 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 813018461 dimer interface [polypeptide binding]; other site 813018462 motif 1; other site 813018463 active site 813018464 motif 2; other site 813018465 motif 3; other site 813018466 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 813018467 anticodon binding site; other site 813018468 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 813018469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813018470 putative substrate translocation pore; other site 813018471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813018472 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 813018473 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 813018474 active site 813018475 PHP Thumb interface [polypeptide binding]; other site 813018476 metal binding site [ion binding]; metal-binding site 813018477 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 813018478 generic binding surface I; other site 813018479 generic binding surface II; other site 813018480 TPR repeat; Region: TPR_11; pfam13414 813018481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813018482 binding surface 813018483 TPR motif; other site 813018484 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 813018485 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 813018486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 813018487 Mg2+ binding site [ion binding]; other site 813018488 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 813018489 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 813018490 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 813018491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813018492 S-adenosylmethionine binding site [chemical binding]; other site 813018493 branched-chain amino acid uptake carrier; Region: livcs; TIGR00796 813018494 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 813018495 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813018496 ATP binding site [chemical binding]; other site 813018497 putative Mg++ binding site [ion binding]; other site 813018498 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813018499 ATP-binding site [chemical binding]; other site 813018500 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 813018501 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 813018502 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 813018503 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 813018504 lipoate synthase; Region: lipA; TIGR00510 813018505 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813018506 FeS/SAM binding site; other site 813018507 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 813018508 type III secretion system protein; Validated; Region: PRK06328 813018509 Flagellar assembly protein FliH; Region: FliH; pfam02108 813018510 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 813018511 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 813018512 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 813018513 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 813018514 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 813018515 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 813018516 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 813018517 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 813018518 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 813018519 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 813018520 Walker A motif; other site 813018521 ATP binding site [chemical binding]; other site 813018522 Walker B motif; other site 813018523 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 813018524 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813018525 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 813018526 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 813018527 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 813018528 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 813018529 active site 813018530 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 813018531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813018532 ATP binding site [chemical binding]; other site 813018533 Mg2+ binding site [ion binding]; other site 813018534 G-X-G motif; other site 813018535 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 813018536 ATP binding site [chemical binding]; other site 813018537 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 813018538 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 813018539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813018540 binding surface 813018541 TPR motif; other site 813018542 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 813018543 EamA-like transporter family; Region: EamA; pfam00892 813018544 EamA-like transporter family; Region: EamA; pfam00892 813018545 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 813018546 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 813018547 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 813018548 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 813018549 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 813018550 active site 813018551 HIGH motif; other site 813018552 dimer interface [polypeptide binding]; other site 813018553 KMSKS motif; other site 813018554 excinuclease ABC subunit B; Provisional; Region: PRK05298 813018555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813018556 ATP binding site [chemical binding]; other site 813018557 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813018558 nucleotide binding region [chemical binding]; other site 813018559 ATP-binding site [chemical binding]; other site 813018560 Ultra-violet resistance protein B; Region: UvrB; pfam12344 813018561 enolase; Provisional; Region: eno; PRK00077 813018562 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 813018563 dimer interface [polypeptide binding]; other site 813018564 metal binding site [ion binding]; metal-binding site 813018565 substrate binding pocket [chemical binding]; other site 813018566 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 813018567 HAMP domain; Region: HAMP; pfam00672 813018568 dimerization interface [polypeptide binding]; other site 813018569 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 813018570 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 813018571 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 813018572 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 813018573 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 813018574 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 813018575 Iron-sulfur protein interface; other site 813018576 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 813018577 proximal heme binding site [chemical binding]; other site 813018578 Iron-sulfur protein interface; other site 813018579 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 813018580 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 813018581 active site 813018582 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 813018583 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 813018584 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 813018585 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 813018586 DsbD alpha interface [polypeptide binding]; other site 813018587 catalytic residues [active] 813018588 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 813018589 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 813018590 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 813018591 translocation protein TolB; Provisional; Region: tolB; PRK01029 813018592 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813018593 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813018594 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813018595 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 813018596 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 813018597 ligand binding site [chemical binding]; other site 813018598 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 813018599 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813018600 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 813018601 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 813018602 dimer interface [polypeptide binding]; other site 813018603 decamer (pentamer of dimers) interface [polypeptide binding]; other site 813018604 catalytic triad [active] 813018605 peroxidatic and resolving cysteines [active] 813018606 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 813018607 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 813018608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 813018609 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 813018610 ligand binding site [chemical binding]; other site 813018611 active site 813018612 UGI interface [polypeptide binding]; other site 813018613 catalytic site [active] 813018614 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 813018615 Part of AAA domain; Region: AAA_19; pfam13245 813018616 Family description; Region: UvrD_C_2; pfam13538 813018617 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 813018618 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 813018619 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 813018620 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 813018621 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 813018622 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 813018623 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 813018624 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 813018625 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 813018626 folate binding site [chemical binding]; other site 813018627 NADP+ binding site [chemical binding]; other site 813018628 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 813018629 catalytic center binding site [active] 813018630 ATP binding site [chemical binding]; other site 813018631 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 813018632 dihydropteroate synthase; Region: DHPS; TIGR01496 813018633 substrate binding pocket [chemical binding]; other site 813018634 dimer interface [polypeptide binding]; other site 813018635 inhibitor binding site; inhibition site 813018636 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 813018637 homooctamer interface [polypeptide binding]; other site 813018638 active site 813018639 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 813018640 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 813018641 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 813018642 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 813018643 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 813018644 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 813018645 DNA binding residues [nucleotide binding] 813018646 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 813018647 Effector from type III secretion system; Region: Effector_1; pfam04518 813018648 Effector from type III secretion system; Region: Effector_1; pfam04518 813018649 Effector from type III secretion system; Region: Effector_1; pfam04518 813018650 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 813018651 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 813018652 MviN-like protein; Region: MVIN; pfam03023 813018653 endonuclease IV; Provisional; Region: PRK01060 813018654 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 813018655 AP (apurinic/apyrimidinic) site pocket; other site 813018656 DNA interaction; other site 813018657 Metal-binding active site; metal-binding site 813018658 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 813018659 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 813018660 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813018661 RNA binding surface [nucleotide binding]; other site 813018662 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 813018663 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 813018664 active site residue [active] 813018665 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 813018666 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 813018667 substrate binding pocket [chemical binding]; other site 813018668 chain length determination region; other site 813018669 substrate-Mg2+ binding site; other site 813018670 catalytic residues [active] 813018671 aspartate-rich region 1; other site 813018672 active site lid residues [active] 813018673 aspartate-rich region 2; other site 813018674 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 813018675 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 813018676 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 813018677 DNA binding site [nucleotide binding] 813018678 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 813018679 Thymidylate synthase complementing protein; Region: Thy1; cl03630 813018680 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 813018681 dimer interface [polypeptide binding]; other site 813018682 active site 813018683 aspartate-rich active site metal binding site; other site 813018684 allosteric magnesium binding site [ion binding]; other site 813018685 Schiff base residues; other site 813018686 NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit; Region: nqrA; TIGR01936 813018687 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 813018688 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 813018689 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 813018690 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 813018691 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 813018692 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 813018693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813018694 homodimer interface [polypeptide binding]; other site 813018695 catalytic residue [active] 813018696 rod shape-determining protein MreC; Provisional; Region: PRK14872 813018697 rod shape-determining protein MreC; Region: MreC; pfam04085 813018698 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 813018699 Part of AAA domain; Region: AAA_19; pfam13245 813018700 Family description; Region: UvrD_C_2; pfam13538 813018701 Major Facilitator Superfamily; Region: MFS_1; pfam07690 813018702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813018703 putative substrate translocation pore; other site 813018704 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 813018705 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 813018706 active site 813018707 interdomain interaction site; other site 813018708 putative metal-binding site [ion binding]; other site 813018709 nucleotide binding site [chemical binding]; other site 813018710 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 813018711 domain I; other site 813018712 DNA binding groove [nucleotide binding] 813018713 phosphate binding site [ion binding]; other site 813018714 domain II; other site 813018715 domain III; other site 813018716 nucleotide binding site [chemical binding]; other site 813018717 catalytic site [active] 813018718 domain IV; other site 813018719 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813018720 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813018721 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813018722 SWI complex, BAF60b domains; Region: SWIB; smart00151 813018723 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 813018724 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 813018725 FMN binding site [chemical binding]; other site 813018726 active site 813018727 catalytic residues [active] 813018728 substrate binding site [chemical binding]; other site 813018729 Predicted integral membrane protein [Function unknown]; Region: COG0762 813018730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813018731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813018732 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 813018733 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 813018734 recombinase A; Provisional; Region: recA; PRK09354 813018735 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 813018736 hexamer interface [polypeptide binding]; other site 813018737 Walker A motif; other site 813018738 ATP binding site [chemical binding]; other site 813018739 Walker B motif; other site 813018740 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 813018741 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 813018742 AAA domain; Region: AAA_30; pfam13604 813018743 Family description; Region: UvrD_C_2; pfam13538 813018744 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 813018745 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 813018746 Walker A/P-loop; other site 813018747 ATP binding site [chemical binding]; other site 813018748 Q-loop/lid; other site 813018749 ABC transporter signature motif; other site 813018750 Walker B; other site 813018751 D-loop; other site 813018752 H-loop/switch region; other site 813018753 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 813018754 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 813018755 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 813018756 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 813018757 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813018758 RNA binding surface [nucleotide binding]; other site 813018759 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 813018760 active site 813018761 hypothetical protein; Provisional; Region: PRK01064 813018762 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 813018763 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 813018764 DNA Topoisomerase IV; Region: TOP4c; smart00434 813018765 CAP-like domain; other site 813018766 active site 813018767 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 813018768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813018769 ATP binding site [chemical binding]; other site 813018770 Mg2+ binding site [ion binding]; other site 813018771 G-X-G motif; other site 813018772 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 813018773 ATP binding site [chemical binding]; other site 813018774 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 813018775 active site 813018776 putative metal-binding site [ion binding]; other site 813018777 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 813018778 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 813018779 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 813018780 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813018781 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 813018782 phosphopeptide binding site; other site 813018783 MARCKS family; Region: MARCKS; pfam02063 813018784 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 813018785 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 813018786 phosphopeptide binding site; other site 813018787 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 813018788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 813018789 binding surface 813018790 Tetratricopeptide repeat; Region: TPR_16; pfam13432 813018791 TPR motif; other site 813018792 type III secretion system ATPase; Provisional; Region: PRK06315 813018793 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813018794 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 813018795 Walker A motif/ATP binding site; other site 813018796 Walker B motif; other site 813018797 type III secretion system protein; Validated; Region: PRK05933 813018798 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 813018799 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 813018800 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813018801 active site 813018802 ATP binding site [chemical binding]; other site 813018803 substrate binding site [chemical binding]; other site 813018804 activation loop (A-loop); other site 813018805 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 813018806 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813018807 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813018808 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 813018809 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 813018810 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 813018811 ADP binding site [chemical binding]; other site 813018812 phosphagen binding site; other site 813018813 substrate specificity loop; other site 813018814 ribosome recycling factor; Reviewed; Region: frr; PRK00083 813018815 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 813018816 hinge region; other site 813018817 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 813018818 putative nucleotide binding site [chemical binding]; other site 813018819 uridine monophosphate binding site [chemical binding]; other site 813018820 homohexameric interface [polypeptide binding]; other site 813018821 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 813018822 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 813018823 Elongation factor TS; Region: EF_TS; pfam00889 813018824 Elongation factor TS; Region: EF_TS; pfam00889 813018825 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 813018826 rRNA interaction site [nucleotide binding]; other site 813018827 S8 interaction site; other site 813018828 putative laminin-1 binding site; other site 813018829 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 813018830 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 813018831 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 813018832 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 813018833 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 813018834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813018835 TPR motif; other site 813018836 Tetratricopeptide repeat; Region: TPR_16; pfam13432 813018837 binding surface 813018838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813018839 binding surface 813018840 TPR motif; other site 813018841 TPR repeat; Region: TPR_11; pfam13414 813018842 TPR repeat; Region: TPR_11; pfam13414 813018843 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813018844 binding surface 813018845 TPR motif; other site 813018846 TPR repeat; Region: TPR_11; pfam13414 813018847 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 813018848 putative ABC transporter; Region: ycf24; CHL00085 813018849 FeS assembly ATPase SufC; Region: sufC; TIGR01978 813018850 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 813018851 Walker A/P-loop; other site 813018852 ATP binding site [chemical binding]; other site 813018853 Q-loop/lid; other site 813018854 ABC transporter signature motif; other site 813018855 Walker B; other site 813018856 D-loop; other site 813018857 H-loop/switch region; other site 813018858 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 813018859 FeS assembly protein SufD; Region: sufD; TIGR01981 813018860 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 813018861 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 813018862 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813018863 catalytic residue [active] 813018864 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 813018865 ParB-like nuclease domain; Region: ParBc; pfam02195 813018866 KorB domain; Region: KorB; pfam08535 813018867 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813018868 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 813018869 Walker A/P-loop; other site 813018870 ATP binding site [chemical binding]; other site 813018871 Q-loop/lid; other site 813018872 ABC transporter signature motif; other site 813018873 Walker B; other site 813018874 D-loop; other site 813018875 H-loop/switch region; other site 813018876 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813018877 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 813018878 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813018879 Walker A/P-loop; other site 813018880 ATP binding site [chemical binding]; other site 813018881 Q-loop/lid; other site 813018882 ABC transporter signature motif; other site 813018883 Walker B; other site 813018884 D-loop; other site 813018885 H-loop/switch region; other site 813018886 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813018887 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 813018888 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 813018889 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 813018890 Phosphoglycerate kinase; Region: PGK; pfam00162 813018891 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 813018892 substrate binding site [chemical binding]; other site 813018893 hinge regions; other site 813018894 ADP binding site [chemical binding]; other site 813018895 catalytic site [active] 813018896 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 813018897 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 813018898 minor groove reading motif; other site 813018899 helix-hairpin-helix signature motif; other site 813018900 substrate binding pocket [chemical binding]; other site 813018901 active site 813018902 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 813018903 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 813018904 trmE is a tRNA modification GTPase; Region: trmE; cd04164 813018905 G1 box; other site 813018906 GTP/Mg2+ binding site [chemical binding]; other site 813018907 Switch I region; other site 813018908 G2 box; other site 813018909 Switch II region; other site 813018910 G3 box; other site 813018911 G4 box; other site 813018912 G5 box; other site 813018913 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 813018914 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 813018915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813018916 binding surface 813018917 TPR motif; other site 813018918 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 813018919 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 813018920 ATP binding site [chemical binding]; other site 813018921 putative Mg++ binding site [ion binding]; other site 813018922 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 813018923 Predicted GTPases [General function prediction only]; Region: COG1160 813018924 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 813018925 G1 box; other site 813018926 GTP/Mg2+ binding site [chemical binding]; other site 813018927 Switch I region; other site 813018928 G2 box; other site 813018929 Switch II region; other site 813018930 G3 box; other site 813018931 G4 box; other site 813018932 G5 box; other site 813018933 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 813018934 G1 box; other site 813018935 GTP/Mg2+ binding site [chemical binding]; other site 813018936 Switch I region; other site 813018937 G2 box; other site 813018938 G3 box; other site 813018939 Switch II region; other site 813018940 G4 box; other site 813018941 G5 box; other site 813018942 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 813018943 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 813018944 active site 813018945 NTP binding site [chemical binding]; other site 813018946 metal binding triad [ion binding]; metal-binding site 813018947 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 813018948 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 813018949 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 813018950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813018951 Walker A motif; other site 813018952 ATP binding site [chemical binding]; other site 813018953 Walker B motif; other site 813018954 arginine finger; other site 813018955 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 813018956 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 813018957 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 813018958 oligomer interface [polypeptide binding]; other site 813018959 active site residues [active] 813018960 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 813018961 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 813018962 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 813018963 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 813018964 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813018965 ATP binding site [chemical binding]; other site 813018966 putative Mg++ binding site [ion binding]; other site 813018967 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813018968 nucleotide binding region [chemical binding]; other site 813018969 ATP-binding site [chemical binding]; other site 813018970 rod shape-determining protein MreB; Provisional; Region: PRK13927 813018971 MreB and similar proteins; Region: MreB_like; cd10225 813018972 nucleotide binding site [chemical binding]; other site 813018973 Mg binding site [ion binding]; other site 813018974 putative protofilament interaction site [polypeptide binding]; other site 813018975 RodZ interaction site [polypeptide binding]; other site 813018976 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 813018977 active site 813018978 substrate-binding site [chemical binding]; other site 813018979 metal-binding site [ion binding] 813018980 GTP binding site [chemical binding]; other site 813018981 Effector from type III secretion system; Region: Effector_1; pfam04518 813018982 Effector from type III secretion system; Region: Effector_1; pfam04518 813018983 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 813018984 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 813018985 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 813018986 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 813018987 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 813018988 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 813018989 active site 813018990 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 813018991 type III secretion system ATPase; Validated; Region: PRK05922 813018992 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813018993 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 813018994 Walker A motif; other site 813018995 ATP binding site [chemical binding]; other site 813018996 Walker B motif; other site 813018997 type III secretion system protein; Validated; Region: PRK05934 813018998 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 813018999 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 813019000 active site 813019001 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 813019002 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 813019003 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813019004 catalytic residue [active] 813019005 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 813019006 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813019007 RNA binding surface [nucleotide binding]; other site 813019008 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 813019009 active site 813019010 biotin--protein ligase; Provisional; Region: PRK05935 813019011 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 813019012 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 813019013 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 813019014 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 813019015 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 813019016 motif II; other site 813019017 CCC1-related protein family; Region: CCC1_like_1; cd02437 813019018 seryl-tRNA synthetase; Provisional; Region: PRK05431 813019019 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 813019020 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 813019021 dimer interface [polypeptide binding]; other site 813019022 active site 813019023 motif 1; other site 813019024 motif 2; other site 813019025 motif 3; other site 813019026 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 813019027 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 813019028 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 813019029 dimerization interface [polypeptide binding]; other site 813019030 active site 813019031 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 813019032 homopentamer interface [polypeptide binding]; other site 813019033 active site 813019034 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 813019035 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 813019036 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 813019037 substrate binding site [chemical binding]; other site 813019038 Proteins containing SET domain [General function prediction only]; Region: COG2940 813019039 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 813019040 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 813019041 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 813019042 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 813019043 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 813019044 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 813019045 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 813019046 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 813019047 catalytic loop [active] 813019048 iron binding site [ion binding]; other site 813019049 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 813019050 FAD binding pocket [chemical binding]; other site 813019051 FAD binding motif [chemical binding]; other site 813019052 phosphate binding motif [ion binding]; other site 813019053 beta-alpha-beta structure motif; other site 813019054 NAD binding pocket [chemical binding]; other site 813019055 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 813019056 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 813019057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813019058 S-adenosylmethionine binding site [chemical binding]; other site 813019059 Histone H1-like protein Hc1; Region: Hc1; pfam07432 813019060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813019061 binding surface 813019062 TPR motif; other site 813019063 Tetratricopeptide repeat; Region: TPR_12; pfam13424 813019064 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 813019065 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 813019066 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 813019067 HemN C-terminal domain; Region: HemN_C; pfam06969 813019068 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 813019069 substrate binding site [chemical binding]; other site 813019070 active site 813019071 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 813019072 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 813019073 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813019074 ATP binding site [chemical binding]; other site 813019075 putative Mg++ binding site [ion binding]; other site 813019076 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813019077 nucleotide binding region [chemical binding]; other site 813019078 ATP-binding site [chemical binding]; other site 813019079 TRCF domain; Region: TRCF; pfam03461 813019080 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 813019081 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 813019082 motif 1; other site 813019083 active site 813019084 motif 2; other site 813019085 motif 3; other site 813019086 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 813019087 DHHA1 domain; Region: DHHA1; pfam02272 813019088 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 813019089 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 813019090 TPP-binding site [chemical binding]; other site 813019091 dimer interface [polypeptide binding]; other site 813019092 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 813019093 PYR/PP interface [polypeptide binding]; other site 813019094 dimer interface [polypeptide binding]; other site 813019095 TPP binding site [chemical binding]; other site 813019096 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813019097 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 813019098 elongation factor P; Validated; Region: PRK00529 813019099 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 813019100 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 813019101 RNA binding site [nucleotide binding]; other site 813019102 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 813019103 RNA binding site [nucleotide binding]; other site 813019104 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813019105 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 813019106 putative active site [active] 813019107 putative metal binding site [ion binding]; other site 813019108 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 813019109 active site 813019110 metal binding site [ion binding]; metal-binding site 813019111 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 813019112 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 813019113 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 813019114 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813019115 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813019116 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 813019117 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 813019118 Mg++ binding site [ion binding]; other site 813019119 putative catalytic motif [active] 813019120 putative substrate binding site [chemical binding]; other site 813019121 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 813019122 TrkA-N domain; Region: TrkA_N; pfam02254 813019123 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813019124 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813019125 cell division protein FtsW; Region: ftsW; TIGR02614 813019126 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 813019127 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 813019128 active site 813019129 homodimer interface [polypeptide binding]; other site 813019130 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 813019131 anti sigma factor interaction site; other site 813019132 regulatory phosphorylation site [posttranslational modification]; other site 813019133 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 813019134 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 813019135 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813019136 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 813019137 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 813019138 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 813019139 dimer interface [polypeptide binding]; other site 813019140 active site 813019141 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 813019142 active site 813019143 Ap4A binding cleft/pocket [chemical binding]; other site 813019144 P4 phosphate binding site; other site 813019145 nudix motif; other site 813019146 putative P2/P3 phosphate binding site [ion binding]; other site 813019147 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 813019148 dimer interface [polypeptide binding]; other site 813019149 substrate binding site [chemical binding]; other site 813019150 metal binding sites [ion binding]; metal-binding site 813019151 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 813019152 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 813019153 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 813019154 NAD binding site [chemical binding]; other site 813019155 Phe binding site; other site 813019156 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 813019157 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 813019158 active site 813019159 putative lithium-binding site [ion binding]; other site 813019160 substrate binding site [chemical binding]; other site 813019161 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 813019162 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 813019163 putative acyl-acceptor binding pocket; other site 813019164 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 813019165 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 813019166 acyl-activating enzyme (AAE) consensus motif; other site 813019167 AMP binding site [chemical binding]; other site 813019168 active site 813019169 CoA binding site [chemical binding]; other site 813019170 8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937 813019171 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 813019172 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813019173 catalytic residue [active] 813019174 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 813019175 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813019176 ATP binding site [chemical binding]; other site 813019177 putative Mg++ binding site [ion binding]; other site 813019178 helicase superfamily c-terminal domain; Region: HELICc; smart00490 813019179 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 813019180 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813019181 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 813019182 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 813019183 dimer interface [polypeptide binding]; other site 813019184 putative anticodon binding site; other site 813019185 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813019186 motif 1; other site 813019187 dimer interface [polypeptide binding]; other site 813019188 active site 813019189 motif 2; other site 813019190 motif 3; other site 813019191 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 813019192 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 813019193 active site 813019194 HIGH motif; other site 813019195 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 813019196 KMSKS motif; other site 813019197 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813019198 tRNA binding surface [nucleotide binding]; other site 813019199 anticodon binding site; other site 813019200 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 813019201 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813019202 ribonuclease P; Reviewed; Region: rnpA; PRK00730 813019203 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 813019204 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 813019205 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 813019206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 813019207 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 813019208 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 813019209 GIY-YIG motif/motif A; other site 813019210 active site 813019211 catalytic site [active] 813019212 putative DNA binding site [nucleotide binding]; other site 813019213 metal binding site [ion binding]; metal-binding site 813019214 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 813019215 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 813019216 MutS domain I; Region: MutS_I; pfam01624 813019217 MutS domain II; Region: MutS_II; pfam05188 813019218 MutS domain III; Region: MutS_III; pfam05192 813019219 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 813019220 Walker A/P-loop; other site 813019221 ATP binding site [chemical binding]; other site 813019222 Q-loop/lid; other site 813019223 ABC transporter signature motif; other site 813019224 Walker B; other site 813019225 D-loop; other site 813019226 H-loop/switch region; other site 813019227 DNA primase; Validated; Region: dnaG; PRK05667 813019228 CHC2 zinc finger; Region: zf-CHC2; pfam01807 813019229 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 813019230 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 813019231 active site 813019232 metal binding site [ion binding]; metal-binding site 813019233 interdomain interaction site; other site 813019234 glycogen synthase; Provisional; Region: glgA; PRK00654 813019235 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 813019236 ADP-binding pocket [chemical binding]; other site 813019237 homodimer interface [polypeptide binding]; other site 813019238 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 813019239 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 813019240 5S rRNA interface [nucleotide binding]; other site 813019241 CTC domain interface [polypeptide binding]; other site 813019242 L16 interface [polypeptide binding]; other site 813019243 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 813019244 putative active site [active] 813019245 catalytic residue [active] 813019246 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 813019247 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 813019248 Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359 813019249 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 813019250 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 813019251 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 813019252 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 813019253 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 813019254 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813019255 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813019256 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 813019257 putative acyl-acceptor binding pocket; other site 813019258 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 813019259 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 813019260 homodimer interface [polypeptide binding]; other site 813019261 oligonucleotide binding site [chemical binding]; other site 813019262 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 813019263 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 813019264 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813019265 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813019266 YtxH-like protein; Region: YtxH; cl02079 813019267 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 813019268 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 813019269 active site 813019270 substrate binding site [chemical binding]; other site 813019271 metal binding site [ion binding]; metal-binding site 813019272 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 813019273 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 813019274 glutaminase active site [active] 813019275 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 813019276 dimer interface [polypeptide binding]; other site 813019277 active site 813019278 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 813019279 dimer interface [polypeptide binding]; other site 813019280 active site 813019281 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 813019282 aromatic amino acid transport protein; Region: araaP; TIGR00837 813019283 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 813019284 aromatic amino acid transport protein; Region: araaP; TIGR00837 813019285 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 813019286 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 813019287 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 813019288 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 813019289 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 813019290 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 813019291 CoA-ligase; Region: Ligase_CoA; pfam00549 813019292 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 813019293 CoA binding domain; Region: CoA_binding; smart00881 813019294 CoA-ligase; Region: Ligase_CoA; pfam00549 813019295 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 813019296 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 813019297 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 813019298 protein binding site [polypeptide binding]; other site 813019299 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 813019300 protein binding site [polypeptide binding]; other site 813019301 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 813019302 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 813019303 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813019304 Peptidase M16C associated; Region: M16C_assoc; pfam08367 813019305 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813019306 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 813019307 RmuC family; Region: RmuC; pfam02646 813019308 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 813019309 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 813019310 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 813019311 ATP cone domain; Region: ATP-cone; pfam03477 813019312 ATP cone domain; Region: ATP-cone; pfam03477 813019313 Class I ribonucleotide reductase; Region: RNR_I; cd01679 813019314 active site 813019315 dimer interface [polypeptide binding]; other site 813019316 catalytic residues [active] 813019317 effector binding site; other site 813019318 R2 peptide binding site; other site 813019319 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 813019320 dimer interface [polypeptide binding]; other site 813019321 putative radical transfer pathway; other site 813019322 diiron center [ion binding]; other site 813019323 tyrosyl radical; other site 813019324 Putative methyltransferase; Region: Methyltransf_4; pfam02390 813019325 Methyltransferase domain; Region: Methyltransf_18; pfam12847 813019326 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 813019327 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 813019328 FAD binding domain; Region: FAD_binding_4; pfam01565 813019329 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 813019330 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 813019331 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 813019332 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 813019333 Ribosomal protein L35 [Translation, ribosomal structure and biogenesis]; Region: RpmI; COG0291 813019334 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 813019335 23S rRNA binding site [nucleotide binding]; other site 813019336 L21 binding site [polypeptide binding]; other site 813019337 L13 binding site [polypeptide binding]; other site 813019338 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 813019339 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 813019340 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 813019341 motif 1; other site 813019342 dimer interface [polypeptide binding]; other site 813019343 active site 813019344 motif 2; other site 813019345 motif 3; other site 813019346 Predicted permeases [General function prediction only]; Region: COG0795 813019347 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 813019348 Predicted permeases [General function prediction only]; Region: COG0795 813019349 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 813019350 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 813019351 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 813019352 Ligand Binding Site [chemical binding]; other site 813019353 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 813019354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813019355 Walker A motif; other site 813019356 ATP binding site [chemical binding]; other site 813019357 Walker B motif; other site 813019358 arginine finger; other site 813019359 Peptidase family M41; Region: Peptidase_M41; pfam01434 813019360 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 813019361 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 813019362 RNase E interface [polypeptide binding]; other site 813019363 trimer interface [polypeptide binding]; other site 813019364 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 813019365 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 813019366 RNase E interface [polypeptide binding]; other site 813019367 trimer interface [polypeptide binding]; other site 813019368 active site 813019369 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 813019370 putative nucleic acid binding region [nucleotide binding]; other site 813019371 G-X-X-G motif; other site 813019372 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 813019373 RNA binding site [nucleotide binding]; other site 813019374 domain interface; other site 813019375 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 813019376 16S/18S rRNA binding site [nucleotide binding]; other site 813019377 S13e-L30e interaction site [polypeptide binding]; other site 813019378 25S rRNA binding site [nucleotide binding]; other site 813019379 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 813019380 nucleoside/Zn binding site; other site 813019381 dimer interface [polypeptide binding]; other site 813019382 catalytic motif [active] 813019383 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813019384 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813019385 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813019386 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813019387 methionine aminopeptidase; Provisional; Region: PRK12318 813019388 SEC-C motif; Region: SEC-C; pfam02810 813019389 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 813019390 active site 813019391 MarC family integral membrane protein; Region: MarC; pfam01914 813019392 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 813019393 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 813019394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813019395 dimer interface [polypeptide binding]; other site 813019396 conserved gate region; other site 813019397 putative PBP binding loops; other site 813019398 ABC-ATPase subunit interface; other site 813019399 NMT1/THI5 like; Region: NMT1; pfam09084 813019400 fumarate hydratase, class II; Region: fumC_II; TIGR00979 813019401 Class II fumarases; Region: Fumarase_classII; cd01362 813019402 active site 813019403 tetramer interface [polypeptide binding]; other site 813019404 high affinity sulphate transporter 1; Region: sulP; TIGR00815 813019405 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 813019406 Sulfate transporter family; Region: Sulfate_transp; pfam00916 813019407 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 813019408 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 813019409 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 813019410 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 813019411 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 813019412 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 813019413 active site triad [active] 813019414 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 813019415 LytB protein; Region: LYTB; pfam02401 813019416 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 813019417 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 813019418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 813019419 binding surface 813019420 TPR motif; other site 813019421 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 813019422 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 813019423 active site 813019424 DNA binding site [nucleotide binding] 813019425 Int/Topo IB signature motif; other site 813019426 glycogen branching enzyme; Provisional; Region: PRK05402 813019427 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 813019428 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 813019429 active site 813019430 catalytic site [active] 813019431 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 813019432 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 813019433 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813019434 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813019435 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813019436 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813019437 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813019438 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813019439 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813019440 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813019441 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813019442 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813019443 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813019444 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813019445 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813019446 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813019447 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813019448 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813019449 Uncharacterized conserved protein [Function unknown]; Region: COG2155 813019450 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 813019451 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 813019452 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 813019453 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 813019454 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 813019455 GatB domain; Region: GatB_Yqey; pfam02637 813019456 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 813019457 ribonuclease HIII; Region: rnhC; TIGR00716 813019458 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 813019459 RNA/DNA hybrid binding site [nucleotide binding]; other site 813019460 active site 813019461 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 813019462 Helix-turn-helix domain; Region: HTH_25; pfam13413 813019463 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906 813019464 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 813019465 putative acyl-acceptor binding pocket; other site 813019466 Uncharacterized conserved protein [Function unknown]; Region: COG1624 813019467 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 813019468 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 813019469 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 813019470 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 813019471 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 813019472 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 813019473 HIGH motif; other site 813019474 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 813019475 active site 813019476 KMSKS motif; other site 813019477 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 813019478 tRNA binding surface [nucleotide binding]; other site 813019479 anticodon binding site; other site 813019480 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 813019481 peptide chain release factor 1; Validated; Region: prfA; PRK00591 813019482 PCRF domain; Region: PCRF; pfam03462 813019483 RF-1 domain; Region: RF-1; pfam00472 813019484 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 813019485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813019486 S-adenosylmethionine binding site [chemical binding]; other site 813019487 signal recognition particle protein; Provisional; Region: PRK10867 813019488 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 813019489 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 813019490 P loop; other site 813019491 GTP binding site [chemical binding]; other site 813019492 Signal peptide binding domain; Region: SRP_SPB; pfam02978 813019493 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 813019494 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 813019495 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 813019496 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 813019497 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 813019498 RNA/DNA hybrid binding site [nucleotide binding]; other site 813019499 active site 813019500 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 813019501 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 813019502 catalytic site [active] 813019503 G-X2-G-X-G-K; other site 813019504 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 813019505 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 813019506 active site 813019507 HIGH motif; other site 813019508 KMSKS motif; other site 813019509 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 813019510 tRNA binding surface [nucleotide binding]; other site 813019511 anticodon binding site; other site 813019512 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 813019513 AAA domain; Region: AAA_30; pfam13604 813019514 Family description; Region: UvrD_C_2; pfam13538 813019515 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 813019516 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 813019517 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 813019518 conserved cys residue [active] 813019519 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 813019520 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 813019521 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 813019522 trimer interface [polypeptide binding]; other site 813019523 active site 813019524 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 813019525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813019526 Walker A motif; other site 813019527 ATP binding site [chemical binding]; other site 813019528 Walker B motif; other site 813019529 arginine finger; other site 813019530 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 813019531 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 813019532 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 813019533 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 813019534 active site 813019535 catalytic site [active] 813019536 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813019537 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 813019538 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 813019539 dimer interface [polypeptide binding]; other site 813019540 ssDNA binding site [nucleotide binding]; other site 813019541 tetramer (dimer of dimers) interface [polypeptide binding]; other site 813019542 multifunctional aminopeptidase A; Provisional; Region: PRK00913 813019543 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 813019544 interface (dimer of trimers) [polypeptide binding]; other site 813019545 Substrate-binding/catalytic site; other site 813019546 Zn-binding sites [ion binding]; other site 813019547 hypothetical protein; Provisional; Region: PRK05907 813019548 Predicted methyltransferases [General function prediction only]; Region: COG0313 813019549 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 813019550 putative SAM binding site [chemical binding]; other site 813019551 homodimer interface [polypeptide binding]; other site 813019552 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 813019553 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813019554 FeS/SAM binding site; other site 813019555 HemN C-terminal domain; Region: HemN_C; pfam06969 813019556 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 813019557 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 813019558 TPP-binding site [chemical binding]; other site 813019559 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 813019560 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 813019561 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813019562 E3 interaction surface; other site 813019563 lipoyl attachment site [posttranslational modification]; other site 813019564 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813019565 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 813019566 1-hydroxy-2-methyl-2-(e)-butenyl 4-diphosphate synthase [Lipid metabolism]; Region: gcpE; COG0821 813019567 IncA protein; Region: IncA; pfam04156 813019568 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 813019569 ADP-ribose binding site [chemical binding]; other site 813019570 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 813019571 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 813019572 catalytic loop [active] 813019573 iron binding site [ion binding]; other site 813019574 type III secretion system protein; Validated; Region: PRK05910 813019575 FHIPEP family; Region: FHIPEP; pfam00771 813019576 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 813019577 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 813019578 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 813019579 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 813019580 DNA binding residues [nucleotide binding] 813019581 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 813019582 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 813019583 active site 813019584 HIGH motif; other site 813019585 dimer interface [polypeptide binding]; other site 813019586 KMSKS motif; other site 813019587 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813019588 RNA binding surface [nucleotide binding]; other site 813019589 GTP-binding protein LepA; Provisional; Region: PRK05433 813019590 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 813019591 G1 box; other site 813019592 putative GEF interaction site [polypeptide binding]; other site 813019593 GTP/Mg2+ binding site [chemical binding]; other site 813019594 Switch I region; other site 813019595 G2 box; other site 813019596 G3 box; other site 813019597 Switch II region; other site 813019598 G4 box; other site 813019599 G5 box; other site 813019600 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 813019601 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 813019602 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 813019603 ADP/ATP carrier protein family; Region: AAA; TIGR00769 813019604 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 813019605 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 813019606 intersubunit interface [polypeptide binding]; other site 813019607 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 813019608 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 813019609 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813019610 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813019611 ABC-ATPase subunit interface; other site 813019612 dimer interface [polypeptide binding]; other site 813019613 putative PBP binding regions; other site 813019614 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 813019615 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 813019616 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813019617 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813019618 ABC-ATPase subunit interface; other site 813019619 dimer interface [polypeptide binding]; other site 813019620 putative PBP binding regions; other site 813019621 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 813019622 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 813019623 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 813019624 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 813019625 RIP metalloprotease RseP; Region: TIGR00054 813019626 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 813019627 active site 813019628 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 813019629 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 813019630 putative substrate binding region [chemical binding]; other site 813019631 recF protein; Region: recf; TIGR00611 813019632 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813019633 Walker A/P-loop; other site 813019634 ATP binding site [chemical binding]; other site 813019635 Q-loop/lid; other site 813019636 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813019637 ABC transporter signature motif; other site 813019638 Walker B; other site 813019639 DNA polymerase III subunit beta; Validated; Region: PRK05643 813019640 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 813019641 putative DNA binding surface [nucleotide binding]; other site 813019642 dimer interface [polypeptide binding]; other site 813019643 beta-clamp/clamp loader binding surface; other site 813019644 beta-clamp/translesion DNA polymerase binding surface; other site 813019645 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 813019646 SmpB-tmRNA interface; other site 813019647 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 813019648 ApbE family; Region: ApbE; pfam02424 813019649 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 813019650 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 813019651 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 813019652 homodimer interface [polypeptide binding]; other site 813019653 NADP binding site [chemical binding]; other site 813019654 substrate binding site [chemical binding]; other site 813019655 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813019656 PLD-like domain; Region: PLDc_2; pfam13091 813019657 putative active site [active] 813019658 catalytic site [active] 813019659 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813019660 PLD-like domain; Region: PLDc_2; pfam13091 813019661 putative active site [active] 813019662 catalytic site [active] 813019663 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 813019664 4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446 813019665 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813019666 HrpJ-like domain; Region: HrpJ; pfam07201 813019667 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 813019668 FHIPEP family; Region: FHIPEP; pfam00771 813019669 type III secretion system protein; Validated; Region: PRK06298 813019670 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 813019671 GTP-binding protein YchF; Reviewed; Region: PRK09601 813019672 YchF GTPase; Region: YchF; cd01900 813019673 G1 box; other site 813019674 GTP/Mg2+ binding site [chemical binding]; other site 813019675 Switch I region; other site 813019676 G2 box; other site 813019677 Switch II region; other site 813019678 G3 box; other site 813019679 G4 box; other site 813019680 G5 box; other site 813019681 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 813019682 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 813019683 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 813019684 active site 813019685 Riboflavin kinase; Region: Flavokinase; smart00904 813019686 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 813019687 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 813019688 RNA binding site [nucleotide binding]; other site 813019689 active site 813019690 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 813019691 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 813019692 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 813019693 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 813019694 G1 box; other site 813019695 putative GEF interaction site [polypeptide binding]; other site 813019696 GTP/Mg2+ binding site [chemical binding]; other site 813019697 Switch I region; other site 813019698 G2 box; other site 813019699 G3 box; other site 813019700 Switch II region; other site 813019701 G4 box; other site 813019702 G5 box; other site 813019703 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 813019704 Translation-initiation factor 2; Region: IF-2; pfam11987 813019705 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 813019706 transcription termination factor NusA; Region: NusA; TIGR01953 813019707 NusA N-terminal domain; Region: NusA_N; pfam08529 813019708 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 813019709 RNA binding site [nucleotide binding]; other site 813019710 homodimer interface [polypeptide binding]; other site 813019711 NusA-like KH domain; Region: KH_5; pfam13184 813019712 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 813019713 G-X-X-G motif; other site 813019714 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 813019715 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 813019716 RNA binding site [nucleotide binding]; other site 813019717 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 813019718 RNA binding site [nucleotide binding]; other site 813019719 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813019720 RNA binding site [nucleotide binding]; other site 813019721 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813019722 RNA binding site [nucleotide binding]; other site 813019723 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 813019724 RNA binding site [nucleotide binding]; other site 813019725 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 813019726 RNA binding site [nucleotide binding]; other site 813019727 domain interface; other site 813019728 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 813019729 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 813019730 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 813019731 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 813019732 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 813019733 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 813019734 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 813019735 active site 813019736 motif I; other site 813019737 motif II; other site 813019738 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 813019739 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 813019740 NAD binding site [chemical binding]; other site 813019741 homotetramer interface [polypeptide binding]; other site 813019742 homodimer interface [polypeptide binding]; other site 813019743 substrate binding site [chemical binding]; other site 813019744 active site 813019745 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 813019746 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813019747 RNA binding surface [nucleotide binding]; other site 813019748 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 813019749 active site 813019750 Uncharacterized conserved protein [Function unknown]; Region: COG0327 813019751 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 813019752 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 813019753 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 813019754 ring oligomerisation interface [polypeptide binding]; other site 813019755 ATP/Mg binding site [chemical binding]; other site 813019756 stacking interactions; other site 813019757 hinge regions; other site 813019758 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 813019759 oligomerisation interface [polypeptide binding]; other site 813019760 mobile loop; other site 813019761 roof hairpin; other site 813019762 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 813019763 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 813019764 active site 813019765 Zn binding site [ion binding]; other site 813019766 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 813019767 Clp amino terminal domain; Region: Clp_N; pfam02861 813019768 Clp amino terminal domain; Region: Clp_N; pfam02861 813019769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813019770 Walker A motif; other site 813019771 ATP binding site [chemical binding]; other site 813019772 Walker B motif; other site 813019773 arginine finger; other site 813019774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813019775 Walker A motif; other site 813019776 ATP binding site [chemical binding]; other site 813019777 Walker B motif; other site 813019778 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 813019779 IncA protein; Region: IncA; pfam04156 813019780 elongation factor P; Provisional; Region: PRK12426 813019781 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813019782 RNA binding site [nucleotide binding]; other site 813019783 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 813019784 RNA binding site [nucleotide binding]; other site 813019785 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 813019786 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 813019787 carboxyltransferase (CT) interaction site; other site 813019788 biotinylation site [posttranslational modification]; other site 813019789 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 813019790 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 813019791 ATP-grasp domain; Region: ATP-grasp_4; cl17255 813019792 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 813019793 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 813019794 23S rRNA interface [nucleotide binding]; other site 813019795 L3 interface [polypeptide binding]; other site 813019796 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 813019797 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 813019798 NlpC/P60 family; Region: NLPC_P60; cl17555 813019799 adenylate kinase; Region: adk; TIGR01351 813019800 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 813019801 AMP-binding site [chemical binding]; other site 813019802 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 813019803 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 813019804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813019805 dimer interface [polypeptide binding]; other site 813019806 conserved gate region; other site 813019807 putative PBP binding loops; other site 813019808 ABC-ATPase subunit interface; other site 813019809 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 813019810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813019811 Walker A/P-loop; other site 813019812 ATP binding site [chemical binding]; other site 813019813 Q-loop/lid; other site 813019814 ABC transporter signature motif; other site 813019815 Walker B; other site 813019816 D-loop; other site 813019817 H-loop/switch region; other site 813019818 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 813019819 Methyltransferase domain; Region: Methyltransf_23; pfam13489 813019820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813019821 S-adenosylmethionine binding site [chemical binding]; other site 813019822 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 813019823 Serine hydrolase (FSH1); Region: FSH1; pfam03959 813019824 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 813019825 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 813019826 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 813019827 active site 813019828 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 813019829 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 813019830 conserved hypothetical integral membrane protein; Region: TIGR00697 813019831 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 813019832 SEC-C motif; Region: SEC-C; pfam02810 813019833 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 813019834 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 813019835 nucleotide binding pocket [chemical binding]; other site 813019836 K-X-D-G motif; other site 813019837 catalytic site [active] 813019838 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 813019839 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 813019840 Helix-hairpin-helix motif; Region: HHH; pfam00633 813019841 helix-hairpin-helix signature motif; other site 813019842 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 813019843 Dimer interface [polypeptide binding]; other site 813019844 BRCT sequence motif; other site 813019845 hypothetical protein; Provisional; Region: PRK06184 813019846 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 813019847 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 813019848 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 813019849 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 813019850 FtsX-like permease family; Region: FtsX; pfam02687 813019851 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 813019852 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 813019853 Walker A/P-loop; other site 813019854 ATP binding site [chemical binding]; other site 813019855 Q-loop/lid; other site 813019856 ABC transporter signature motif; other site 813019857 Walker B; other site 813019858 D-loop; other site 813019859 H-loop/switch region; other site 813019860 membrane-attack complex / perforin; Region: MACPF; smart00457 813019861 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 813019862 PLD-like domain; Region: PLDc_2; pfam13091 813019863 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813019864 putative active site [active] 813019865 catalytic site [active] 813019866 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813019867 PLD-like domain; Region: PLDc_2; pfam13091 813019868 putative active site [active] 813019869 catalytic site [active] 813019870 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813019871 PLD-like domain; Region: PLDc_2; pfam13091 813019872 putative active site [active] 813019873 catalytic site [active] 813019874 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813019875 PLD-like domain; Region: PLDc_2; pfam13091 813019876 putative active site [active] 813019877 catalytic site [active] 813019878 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813019879 PLD-like domain; Region: PLDc_2; pfam13091 813019880 putative active site [active] 813019881 catalytic site [active] 813019882 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813019883 PLD-like domain; Region: PLDc_2; pfam13091 813019884 putative active site [active] 813019885 catalytic site [active] 813019886 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813019887 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 813019888 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 813019889 trp operon repressor, proteobacterial; Region: TrpR; TIGR01321 813019890 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 813019891 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 813019892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813019893 catalytic residue [active] 813019894 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 813019895 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 813019896 substrate binding site [chemical binding]; other site 813019897 active site 813019898 catalytic residues [active] 813019899 heterodimer interface [polypeptide binding]; other site 813019900 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 813019901 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 813019902 peptide binding site [polypeptide binding]; other site 813019903 putative disulfide oxidoreductase; Provisional; Region: PRK00611 813019904 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 813019905 putative active site [active] 813019906 redox center [active] 813019907 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 813019908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813019909 Walker A/P-loop; other site 813019910 ATP binding site [chemical binding]; other site 813019911 Q-loop/lid; other site 813019912 ABC transporter signature motif; other site 813019913 Walker B; other site 813019914 D-loop; other site 813019915 H-loop/switch region; other site 813019916 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 813019917 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 813019918 Ligand binding site; other site 813019919 oligomer interface; other site 813019920 CTP synthetase; Validated; Region: pyrG; PRK05380 813019921 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 813019922 Catalytic site [active] 813019923 active site 813019924 UTP binding site [chemical binding]; other site 813019925 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 813019926 active site 813019927 putative oxyanion hole; other site 813019928 catalytic triad [active] 813019929 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 813019930 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 813019931 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 813019932 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 813019933 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 813019934 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 813019935 putative active site [active] 813019936 DNA polymerase III subunit delta'; Validated; Region: PRK05917 813019937 DNA polymerase III subunit delta'; Validated; Region: PRK08485 813019938 thymidylate kinase; Validated; Region: tmk; PRK00698 813019939 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 813019940 TMP-binding site; other site 813019941 ATP-binding site [chemical binding]; other site 813019942 Protein of unknown function (DUF721); Region: DUF721; pfam05258 813019943 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 813019944 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 813019945 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 813019946 MgtE intracellular N domain; Region: MgtE_N; pfam03448 813019947 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 813019948 Divalent cation transporter; Region: MgtE; pfam01769 813019949 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 813019950 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 813019951 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 813019952 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 813019953 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 813019954 peptide binding site [polypeptide binding]; other site 813019955 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 813019956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813019957 dimer interface [polypeptide binding]; other site 813019958 conserved gate region; other site 813019959 putative PBP binding loops; other site 813019960 ABC-ATPase subunit interface; other site 813019961 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 813019962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813019963 dimer interface [polypeptide binding]; other site 813019964 conserved gate region; other site 813019965 putative PBP binding loops; other site 813019966 ABC-ATPase subunit interface; other site 813019967 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813019968 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 813019969 Walker A/P-loop; other site 813019970 ATP binding site [chemical binding]; other site 813019971 Q-loop/lid; other site 813019972 ABC transporter signature motif; other site 813019973 Walker B; other site 813019974 D-loop; other site 813019975 H-loop/switch region; other site 813019976 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 813019977 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 813019978 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813019979 Walker A/P-loop; other site 813019980 ATP binding site [chemical binding]; other site 813019981 Q-loop/lid; other site 813019982 ABC transporter signature motif; other site 813019983 Walker B; other site 813019984 D-loop; other site 813019985 H-loop/switch region; other site 813019986 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813019987 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 813019988 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 813019989 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 813019990 transmembrane helices; other site 813019991 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 813019992 active site 813019993 ADP/pyrophosphate binding site [chemical binding]; other site 813019994 dimerization interface [polypeptide binding]; other site 813019995 allosteric effector site; other site 813019996 fructose-1,6-bisphosphate binding site; other site 813019997 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 813019998 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 813019999 active site 813020000 ADP/pyrophosphate binding site [chemical binding]; other site 813020001 dimerization interface [polypeptide binding]; other site 813020002 allosteric effector site; other site 813020003 fructose-1,6-bisphosphate binding site; other site 813020004 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 813020005 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 813020006 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 813020007 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 813020008 HIGH motif; other site 813020009 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 813020010 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 813020011 active site 813020012 KMSKS motif; other site 813020013 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 813020014 tRNA binding surface [nucleotide binding]; other site 813020015 Putative transcriptional regulator [Transcription]; Region: COG1678 813020016 Uncharacterized conserved protein [Function unknown]; Region: COG1259 813020017 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 813020018 tetramer (dimer of dimers) interface [polypeptide binding]; other site 813020019 active site 813020020 dimer interface [polypeptide binding]; other site 813020021 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 813020022 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 813020023 putative active site; other site 813020024 catalytic residue [active] 813020025 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 813020026 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 813020027 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 813020028 Ligand Binding Site [chemical binding]; other site 813020029 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 813020030 prenyltransferase; Reviewed; Region: ubiA; PRK12876 813020031 UbiA prenyltransferase family; Region: UbiA; pfam01040 813020032 aromatic acid decarboxylase; Validated; Region: PRK05920 813020033 Flavoprotein; Region: Flavoprotein; pfam02441 813020034 Uncharacterized conserved protein [Function unknown]; Region: COG1284 813020035 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 813020036 IncA protein; Region: IncA; pfam04156 813020037 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 813020038 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 813020039 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 813020040 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 813020041 Na2 binding site [ion binding]; other site 813020042 putative substrate binding site 1 [chemical binding]; other site 813020043 Na binding site 1 [ion binding]; other site 813020044 putative substrate binding site 2 [chemical binding]; other site 813020045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813020046 putative substrate translocation pore; other site 813020047 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 813020048 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 813020049 ligand binding site [chemical binding]; other site 813020050 flexible hinge region; other site 813020051 acyl carrier protein; Provisional; Region: acpP; PRK00982 813020052 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 813020053 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 813020054 NAD(P) binding site [chemical binding]; other site 813020055 homotetramer interface [polypeptide binding]; other site 813020056 homodimer interface [polypeptide binding]; other site 813020057 active site 813020058 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 813020059 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 813020060 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 813020061 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 813020062 dimer interface [polypeptide binding]; other site 813020063 active site 813020064 CoA binding pocket [chemical binding]; other site 813020065 recombination protein RecR; Region: recR; TIGR00615 813020066 RecR protein; Region: RecR; pfam02132 813020067 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 813020068 putative active site [active] 813020069 putative metal-binding site [ion binding]; other site 813020070 tetramer interface [polypeptide binding]; other site 813020071 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 813020072 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813020073 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813020074 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813020075 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813020076 Surface antigen; Region: Bac_surface_Ag; pfam01103 813020077 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 813020078 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 813020079 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 813020080 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 813020081 trimer interface [polypeptide binding]; other site 813020082 active site 813020083 UDP-GlcNAc binding site [chemical binding]; other site 813020084 lipid binding site [chemical binding]; lipid-binding site 813020085 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 813020086 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 813020087 tetramer interface [polypeptide binding]; other site 813020088 TPP-binding site [chemical binding]; other site 813020089 heterodimer interface [polypeptide binding]; other site 813020090 phosphorylation loop region [posttranslational modification] 813020091 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 813020092 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 813020093 alpha subunit interface [polypeptide binding]; other site 813020094 TPP binding site [chemical binding]; other site 813020095 heterodimer interface [polypeptide binding]; other site 813020096 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813020097 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 813020098 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813020099 E3 interaction surface; other site 813020100 lipoyl attachment site [posttranslational modification]; other site 813020101 e3 binding domain; Region: E3_binding; pfam02817 813020102 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813020103 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 813020104 homodimer interface [polypeptide binding]; other site 813020105 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 813020106 active site pocket [active] 813020107 chromosomal replication initiation protein; Provisional; Region: PRK12422 813020108 DnaA N-terminal domain; Region: DnaA_N; pfam11638 813020109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813020110 Walker A motif; other site 813020111 ATP binding site [chemical binding]; other site 813020112 Walker B motif; other site 813020113 arginine finger; other site 813020114 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 813020115 DnaA box-binding interface [nucleotide binding]; other site 813020116 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 813020117 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 813020118 homodimer interface [polypeptide binding]; other site 813020119 metal binding site [ion binding]; metal-binding site 813020120 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 813020121 Domain of unknown function DUF21; Region: DUF21; pfam01595 813020122 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813020123 Transporter associated domain; Region: CorC_HlyC; smart01091 813020124 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 813020125 Domain of unknown function DUF21; Region: DUF21; pfam01595 813020126 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813020127 Transporter associated domain; Region: CorC_HlyC; smart01091 813020128 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 813020129 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 813020130 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813020131 catalytic residue [active] 813020132 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 813020133 Protein phosphatase 2C; Region: PP2C; pfam00481 813020134 active site 813020135 Uncharacterized conserved protein [Function unknown]; Region: COG5465 813020136 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 813020137 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 813020138 active site 813020139 catalytic site [active] 813020140 substrate binding site [chemical binding]; other site 813020141 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 813020142 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 813020143 nucleosidase; Provisional; Region: PRK05634 813020144 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 813020145 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 813020146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813020147 Walker A/P-loop; other site 813020148 ATP binding site [chemical binding]; other site 813020149 Q-loop/lid; other site 813020150 ABC transporter signature motif; other site 813020151 Walker B; other site 813020152 D-loop; other site 813020153 H-loop/switch region; other site 813020154 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 813020155 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 813020156 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 813020157 IHF - DNA interface [nucleotide binding]; other site 813020158 IHF dimer interface [polypeptide binding]; other site 813020159 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 813020160 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 813020161 active site 813020162 metal binding site [ion binding]; metal-binding site 813020163 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 813020164 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 813020165 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813020166 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813020167 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 813020168 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 813020169 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 813020170 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 813020171 MraW methylase family; Region: Methyltransf_5; pfam01795 813020172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813020173 TPR motif; other site 813020174 binding surface 813020175 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 813020176 DnaA N-terminal domain; Region: DnaA_N; pfam11638 813020177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813020178 Walker A motif; other site 813020179 ATP binding site [chemical binding]; other site 813020180 Walker B motif; other site 813020181 arginine finger; other site 813020182 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 813020183 DnaA box-binding interface [nucleotide binding]; other site 813020184 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 813020185 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 813020186 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 813020187 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 813020188 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 813020189 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 813020190 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 813020191 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 813020192 lipoyl attachment site [posttranslational modification]; other site 813020193 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 813020194 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 813020195 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813020196 putative active site [active] 813020197 catalytic site [active] 813020198 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813020199 putative active site [active] 813020200 catalytic site [active] 813020201 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 813020202 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 813020203 Clp amino terminal domain; Region: Clp_N; pfam02861 813020204 Clp amino terminal domain; Region: Clp_N; pfam02861 813020205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813020206 Walker A motif; other site 813020207 ATP binding site [chemical binding]; other site 813020208 Walker B motif; other site 813020209 arginine finger; other site 813020210 UvrB/uvrC motif; Region: UVR; pfam02151 813020211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813020212 Walker A motif; other site 813020213 ATP binding site [chemical binding]; other site 813020214 Walker B motif; other site 813020215 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 813020216 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 813020217 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 813020218 Ligand Binding Site [chemical binding]; other site 813020219 Helix-turn-helix domain; Region: HTH_17; pfam12728 813020220 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 813020221 active site 813020222 phosphorylation site [posttranslational modification] 813020223 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 813020224 active site 813020225 phosphorylation site [posttranslational modification] 813020226 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 813020227 trimer interface [polypeptide binding]; other site 813020228 active site 813020229 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 813020230 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 813020231 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 813020232 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 813020233 active site 813020234 substrate binding site [chemical binding]; other site 813020235 metal binding site [ion binding]; metal-binding site 813020236 ribonuclease III; Reviewed; Region: rnc; PRK00102 813020237 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 813020238 dimerization interface [polypeptide binding]; other site 813020239 active site 813020240 metal binding site [ion binding]; metal-binding site 813020241 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 813020242 dsRNA binding site [nucleotide binding]; other site 813020243 DNA repair protein RadA; Provisional; Region: PRK11823 813020244 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 813020245 Walker A motif/ATP binding site; other site 813020246 ATP binding site [chemical binding]; other site 813020247 Walker B motif; other site 813020248 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 813020249 porphobilinogen deaminase; Provisional; Region: PRK01066 813020250 Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379 813020251 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 813020252 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813020253 active site 813020254 ATP binding site [chemical binding]; other site 813020255 substrate binding site [chemical binding]; other site 813020256 activation loop (A-loop); other site 813020257 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 813020258 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 813020259 HIGH motif; other site 813020260 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 813020261 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 813020262 active site 813020263 KMSKS motif; other site 813020264 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 813020265 tRNA binding surface [nucleotide binding]; other site 813020266 anticodon binding site; other site 813020267 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 813020268 V-type ATP synthase subunit K; Provisional; Region: PRK09621 813020269 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 813020270 V-type ATP synthase subunit I; Validated; Region: PRK05771 813020271 Protein of unknown function (DUF1319); Region: DUF1319; pfam07028 813020272 V-type ATP synthase subunit D; Provisional; Region: PRK02195 813020273 V-type ATP synthase subunit B; Provisional; Region: PRK02118 813020274 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813020275 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 813020276 Walker A motif homologous position; other site 813020277 Walker B motif; other site 813020278 V-type ATP synthase subunit A; Provisional; Region: PRK04192 813020279 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813020280 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 813020281 Walker A motif/ATP binding site; other site 813020282 Walker B motif; other site 813020283 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 813020284 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 813020285 V-type ATP synthase subunit E; Provisional; Region: PRK01005 813020286 V-type ATP synthase subunit E; Provisional; Region: PRK01558 813020287 transaldolase-like protein; Provisional; Region: PTZ00411 813020288 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 813020289 active site 813020290 dimer interface [polypeptide binding]; other site 813020291 catalytic residue [active] 813020292 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 813020293 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 813020294 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 813020295 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 813020296 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 813020297 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 813020298 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 813020299 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 813020300 DNA binding site [nucleotide binding] 813020301 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 813020302 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 813020303 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 813020304 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 813020305 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 813020306 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 813020307 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 813020308 RPB12 interaction site [polypeptide binding]; other site 813020309 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 813020310 RPB3 interaction site [polypeptide binding]; other site 813020311 RPB1 interaction site [polypeptide binding]; other site 813020312 RPB11 interaction site [polypeptide binding]; other site 813020313 RPB10 interaction site [polypeptide binding]; other site 813020314 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 813020315 L11 interface [polypeptide binding]; other site 813020316 putative EF-Tu interaction site [polypeptide binding]; other site 813020317 putative EF-G interaction site [polypeptide binding]; other site 813020318 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 813020319 23S rRNA interface [nucleotide binding]; other site 813020320 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 813020321 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 813020322 mRNA/rRNA interface [nucleotide binding]; other site 813020323 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 813020324 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 813020325 putative thiostrepton binding site; other site 813020326 23S rRNA interface [nucleotide binding]; other site 813020327 L7/L12 interface [polypeptide binding]; other site 813020328 L25 interface [polypeptide binding]; other site 813020329 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 813020330 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 813020331 putative homodimer interface [polypeptide binding]; other site 813020332 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 813020333 heterodimer interface [polypeptide binding]; other site 813020334 homodimer interface [polypeptide binding]; other site 813020335 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 813020336 elongation factor Tu; Reviewed; Region: PRK12735 813020337 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 813020338 G1 box; other site 813020339 GEF interaction site [polypeptide binding]; other site 813020340 GTP/Mg2+ binding site [chemical binding]; other site 813020341 Switch I region; other site 813020342 G2 box; other site 813020343 G3 box; other site 813020344 Switch II region; other site 813020345 G4 box; other site 813020346 G5 box; other site 813020347 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 813020348 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 813020349 Antibiotic Binding Site [chemical binding]; other site 813020350 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 813020351 rRNA binding site [nucleotide binding]; other site 813020352 predicted 30S ribosome binding site; other site 813020353 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 813020354 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 813020355 active site 813020356 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 813020357 triosephosphate isomerase; Provisional; Region: PRK14565 813020358 substrate binding site [chemical binding]; other site 813020359 dimer interface [polypeptide binding]; other site 813020360 catalytic triad [active] 813020361 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 813020362 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 813020363 generic binding surface II; other site 813020364 generic binding surface I; other site 813020365 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 813020366 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 813020367 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 813020368 TPP-binding site [chemical binding]; other site 813020369 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 813020370 PYR/PP interface [polypeptide binding]; other site 813020371 dimer interface [polypeptide binding]; other site 813020372 TPP binding site [chemical binding]; other site 813020373 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813020374 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 813020375 pyruvate kinase; Region: pyruv_kin; TIGR01064 813020376 domain interfaces; other site 813020377 active site 813020378 excinuclease ABC subunit A; Provisional; Region: PRK00635 813020379 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 813020380 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 813020381 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 813020382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813020383 Walker A/P-loop; other site 813020384 ATP binding site [chemical binding]; other site 813020385 Q-loop/lid; other site 813020386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813020387 ABC transporter signature motif; other site 813020388 Walker B; other site 813020389 D-loop; other site 813020390 H-loop/switch region; other site 813020391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813020392 Walker A/P-loop; other site 813020393 ATP binding site [chemical binding]; other site 813020394 Q-loop/lid; other site 813020395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813020396 Q-loop/lid; other site 813020397 ABC transporter signature motif; other site 813020398 Walker B; other site 813020399 D-loop; other site 813020400 H-loop/switch region; other site 813020401 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 813020402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813020403 Walker A motif; other site 813020404 ATP binding site [chemical binding]; other site 813020405 Walker B motif; other site 813020406 arginine finger; other site 813020407 hypothetical protein; Validated; Region: PRK00153 813020408 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 813020409 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 813020410 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 813020411 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 813020412 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 813020413 dimerization domain swap beta strand [polypeptide binding]; other site 813020414 regulatory protein interface [polypeptide binding]; other site 813020415 active site 813020416 regulatory phosphorylation site [posttranslational modification]; other site 813020417 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 813020418 Competence protein; Region: Competence; pfam03772 813020419 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 813020420 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 813020421 tetramer interface [polypeptide binding]; other site 813020422 TPP-binding site [chemical binding]; other site 813020423 heterodimer interface [polypeptide binding]; other site 813020424 phosphorylation loop region [posttranslational modification] 813020425 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 813020426 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 813020427 alpha subunit interface [polypeptide binding]; other site 813020428 TPP binding site [chemical binding]; other site 813020429 heterodimer interface [polypeptide binding]; other site 813020430 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813020431 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 813020432 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 813020433 Glycoprotease family; Region: Peptidase_M22; pfam00814 813020434 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 813020435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813020436 Walker A motif; other site 813020437 ATP binding site [chemical binding]; other site 813020438 Walker B motif; other site 813020439 arginine finger; other site 813020440 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 813020441 ribonuclease Z; Region: RNase_Z; TIGR02651 813020442 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 813020443 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 813020444 active site 813020445 Int/Topo IB signature motif; other site 813020446 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 813020447 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813020448 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813020449 ABC transporter; Region: ABC_tran_2; pfam12848 813020450 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813020451 Maf-like protein; Region: Maf; pfam02545 813020452 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 813020453 active site 813020454 dimer interface [polypeptide binding]; other site 813020455 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 813020456 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 813020457 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 813020458 dimethyladenosine transferase; Region: ksgA; TIGR00755 813020459 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 813020460 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 813020461 catalytic residues [active] 813020462 dihydrodipicolinate synthase; Region: dapA; TIGR00674 813020463 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 813020464 inhibitor site; inhibition site 813020465 active site 813020466 dimer interface [polypeptide binding]; other site 813020467 catalytic residue [active] 813020468 aspartate kinase; Provisional; Region: PRK05925 813020469 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 813020470 putative catalytic residues [active] 813020471 nucleotide binding site [chemical binding]; other site 813020472 aspartate binding site [chemical binding]; other site 813020473 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 813020474 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 813020475 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 813020476 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 813020477 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 813020478 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 813020479 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 813020480 hinge; other site 813020481 active site 813020482 shikimate kinase; Provisional; Region: PRK00625 813020483 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 813020484 ADP binding site [chemical binding]; other site 813020485 magnesium binding site [ion binding]; other site 813020486 putative shikimate binding site; other site 813020487 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 813020488 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 813020489 Tetramer interface [polypeptide binding]; other site 813020490 active site 813020491 FMN-binding site [chemical binding]; other site 813020492 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 813020493 active site 813020494 dimer interface [polypeptide binding]; other site 813020495 metal binding site [ion binding]; metal-binding site 813020496 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 813020497 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 813020498 active site 813020499 catalytic residue [active] 813020500 dimer interface [polypeptide binding]; other site 813020501 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 813020502 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 813020503 shikimate binding site; other site 813020504 NAD(P) binding site [chemical binding]; other site 813020505 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 813020506 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 813020507 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 813020508 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 813020509 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 813020510 malate dehydrogenase; Provisional; Region: PRK05442 813020511 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 813020512 NAD(P) binding site [chemical binding]; other site 813020513 dimer interface [polypeptide binding]; other site 813020514 malate binding site [chemical binding]; other site 813020515 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 813020516 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 813020517 active site 813020518 dimer interface [polypeptide binding]; other site 813020519 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 813020520 dimer interface [polypeptide binding]; other site 813020521 active site 813020522 GTPases [General function prediction only]; Region: HflX; COG2262 813020523 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 813020524 HflX GTPase family; Region: HflX; cd01878 813020525 G1 box; other site 813020526 GTP/Mg2+ binding site [chemical binding]; other site 813020527 Switch I region; other site 813020528 G2 box; other site 813020529 G3 box; other site 813020530 Switch II region; other site 813020531 G4 box; other site 813020532 G5 box; other site 813020533 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 813020534 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 813020535 substrate binding pocket [chemical binding]; other site 813020536 membrane-bound complex binding site; other site 813020537 hinge residues; other site 813020538 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 813020539 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 813020540 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 813020541 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 813020542 nucleotide binding site/active site [active] 813020543 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 813020544 hypothetical protein; Validated; Region: PRK00647 813020545 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 813020546 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 813020547 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 813020548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813020549 homodimer interface [polypeptide binding]; other site 813020550 catalytic residue [active] 813020551 ABC transporter substrate binding protein; Region: ABC_sub_bind; pfam04392 813020552 prolyl-tRNA synthetase; Provisional; Region: PRK09194 813020553 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 813020554 dimer interface [polypeptide binding]; other site 813020555 motif 1; other site 813020556 active site 813020557 motif 2; other site 813020558 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 813020559 putative deacylase active site [active] 813020560 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813020561 active site 813020562 motif 3; other site 813020563 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 813020564 anticodon binding site; other site 813020565 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 813020566 GrpE; Region: GrpE; pfam01025 813020567 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 813020568 dimer interface [polypeptide binding]; other site 813020569 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 813020570 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 813020571 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 813020572 nucleotide binding site [chemical binding]; other site 813020573 NEF interaction site [polypeptide binding]; other site 813020574 SBD interface [polypeptide binding]; other site 813020575 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 813020576 Exoribonuclease R [Transcription]; Region: VacB; COG0557 813020577 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 813020578 RNB domain; Region: RNB; pfam00773 813020579 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 813020580 Putative zinc ribbon domain; Region: DUF164; pfam02591 813020581 KpsF/GutQ family protein; Region: kpsF; TIGR00393 813020582 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 813020583 putative active site [active] 813020584 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 813020585 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 813020586 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813020587 E3 interaction surface; other site 813020588 lipoyl attachment site [posttranslational modification]; other site 813020589 e3 binding domain; Region: E3_binding; pfam02817 813020590 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813020591 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 813020592 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 813020593 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 813020594 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 813020595 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 813020596 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 813020597 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 813020598 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 813020599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813020600 S-adenosylmethionine binding site [chemical binding]; other site 813020601 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 813020602 Lumazine binding domain; Region: Lum_binding; pfam00677 813020603 Lumazine binding domain; Region: Lum_binding; pfam00677 813020604 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 813020605 ATP cone domain; Region: ATP-cone; pfam03477 813020606 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 813020607 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 813020608 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 813020609 amino acid carrier protein; Region: agcS; TIGR00835 813020610 poly(A) polymerase; Region: pcnB; TIGR01942 813020611 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 813020612 active site 813020613 NTP binding site [chemical binding]; other site 813020614 metal binding triad [ion binding]; metal-binding site 813020615 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 813020616 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 813020617 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 813020618 Predicted membrane protein [Function unknown]; Region: COG3952 813020619 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 813020620 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813020621 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813020622 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813020623 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813020624 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813020625 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813020626 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 813020627 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 813020628 intersubunit interface [polypeptide binding]; other site 813020629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813020630 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 813020631 Walker A/P-loop; other site 813020632 ATP binding site [chemical binding]; other site 813020633 Q-loop/lid; other site 813020634 ABC transporter signature motif; other site 813020635 Walker B; other site 813020636 D-loop; other site 813020637 H-loop/switch region; other site 813020638 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813020639 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813020640 ABC-ATPase subunit interface; other site 813020641 dimer interface [polypeptide binding]; other site 813020642 putative PBP binding regions; other site 813020643 GTPase CgtA; Reviewed; Region: obgE; PRK12299 813020644 GTP1/OBG; Region: GTP1_OBG; pfam01018 813020645 Obg GTPase; Region: Obg; cd01898 813020646 G1 box; other site 813020647 GTP/Mg2+ binding site [chemical binding]; other site 813020648 Switch I region; other site 813020649 G2 box; other site 813020650 G3 box; other site 813020651 Switch II region; other site 813020652 G4 box; other site 813020653 G5 box; other site 813020654 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 813020655 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 813020656 Uncharacterized conserved protein [Function unknown]; Region: COG2928 813020657 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 813020658 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 813020659 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 813020660 anti sigma factor interaction site; other site 813020661 regulatory phosphorylation site [posttranslational modification]; other site 813020662 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 813020663 hypothetical protein; Provisional; Region: PRK05926 813020664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813020665 FeS/SAM binding site; other site 813020666 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 813020667 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 813020668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813020669 S-adenosylmethionine binding site [chemical binding]; other site 813020670 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 813020671 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 813020672 diaminopimelate epimerase; Region: DapF; TIGR00652 813020673 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 813020674 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 813020675 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 813020676 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 813020677 oligomer interface [polypeptide binding]; other site 813020678 active site residues [active] 813020679 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 813020680 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 813020681 active site 813020682 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 813020683 homotrimer interaction site [polypeptide binding]; other site 813020684 zinc binding site [ion binding]; other site 813020685 CDP-binding sites; other site 813020686 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 813020687 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 813020688 FAD binding pocket [chemical binding]; other site 813020689 conserved FAD binding motif [chemical binding]; other site 813020690 phosphate binding motif [ion binding]; other site 813020691 beta-alpha-beta structure motif; other site 813020692 NAD binding pocket [chemical binding]; other site 813020693 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 813020694 elongation factor G; Reviewed; Region: PRK12739 813020695 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 813020696 G1 box; other site 813020697 putative GEF interaction site [polypeptide binding]; other site 813020698 GTP/Mg2+ binding site [chemical binding]; other site 813020699 Switch I region; other site 813020700 G2 box; other site 813020701 G3 box; other site 813020702 Switch II region; other site 813020703 G4 box; other site 813020704 G5 box; other site 813020705 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 813020706 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 813020707 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 813020708 30S ribosomal protein S7; Validated; Region: PRK05302 813020709 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 813020710 S17 interaction site [polypeptide binding]; other site 813020711 S8 interaction site; other site 813020712 16S rRNA interaction site [nucleotide binding]; other site 813020713 streptomycin interaction site [chemical binding]; other site 813020714 23S rRNA interaction site [nucleotide binding]; other site 813020715 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 813020716 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 813020717 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 813020718 protein binding site [polypeptide binding]; other site 813020719 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 813020720 Catalytic dyad [active] 813020721 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 813020722 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 813020723 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 813020724 Domain of unknown function DUF11; Region: DUF11; pfam01345 813020725 Domain of unknown function DUF11; Region: DUF11; pfam01345 813020726 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 813020727 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 813020728 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 813020729 HIGH motif; other site 813020730 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 813020731 active site 813020732 KMSKS motif; other site 813020733 Helix-turn-helix domain; Region: HTH_17; pfam12728 813020734 Helix-turn-helix domain; Region: HTH_17; cl17695 813020735 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 813020736 DHH family; Region: DHH; pfam01368 813020737 DHHA1 domain; Region: DHHA1; pfam02272 813020738 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 813020739 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 813020740 Protein export membrane protein; Region: SecD_SecF; pfam02355 813020741 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 813020742 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 813020743 catalytic residue [active] 813020744 putative FPP diphosphate binding site; other site 813020745 putative FPP binding hydrophobic cleft; other site 813020746 dimer interface [polypeptide binding]; other site 813020747 putative IPP diphosphate binding site; other site 813020748 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 813020749 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 813020750 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 813020751 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 813020752 CMP-binding site; other site 813020753 The sites determining sugar specificity; other site 813020754 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 813020755 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 813020756 putative acyl-acceptor binding pocket; other site 813020757 arginine-tRNA ligase; Region: PLN02286 813020758 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 813020759 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 813020760 active site 813020761 HIGH motif; other site 813020762 KMSK motif region; other site 813020763 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813020764 tRNA binding surface [nucleotide binding]; other site 813020765 anticodon binding site; other site 813020766 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 813020767 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 813020768 hinge; other site 813020769 active site 813020770 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 813020771 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 813020772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 813020773 Coenzyme A binding pocket [chemical binding]; other site 813020774 PCRF domain; Region: PCRF; pfam03462 813020775 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 813020776 RF-1 domain; Region: RF-1; pfam00472 813020777 SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531 813020778 SWI complex, BAF60b domains; Region: SWIB; smart00151 813020779 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 813020780 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813020781 putative active site [active] 813020782 putative metal binding site [ion binding]; other site 813020783 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 813020784 substrate binding site; other site 813020785 dimer interface; other site 813020786 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 813020787 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 813020788 dimerization interface 3.5A [polypeptide binding]; other site 813020789 active site 813020790 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 813020791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 813020792 active site 813020793 motif I; other site 813020794 motif II; other site 813020795 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 813020796 PAS domain; Region: PAS; smart00091 813020797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 813020798 dimer interface [polypeptide binding]; other site 813020799 phosphorylation site [posttranslational modification] 813020800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813020801 ATP binding site [chemical binding]; other site 813020802 Mg2+ binding site [ion binding]; other site 813020803 G-X-G motif; other site 813020804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 813020805 Response regulator receiver domain; Region: Response_reg; pfam00072 813020806 active site 813020807 phosphorylation site [posttranslational modification] 813020808 intermolecular recognition site; other site 813020809 dimerization interface [polypeptide binding]; other site 813020810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813020811 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 813020812 Walker A motif; other site 813020813 ATP binding site [chemical binding]; other site 813020814 Walker B motif; other site 813020815 arginine finger; other site 813020816 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 813020817 Uncharacterized conserved protein [Function unknown]; Region: COG1723 813020818 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 813020819 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 813020820 putative tRNA-binding site [nucleotide binding]; other site 813020821 B3/4 domain; Region: B3_4; pfam03483 813020822 tRNA synthetase B5 domain; Region: B5; pfam03484 813020823 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 813020824 dimer interface [polypeptide binding]; other site 813020825 motif 1; other site 813020826 motif 3; other site 813020827 motif 2; other site 813020828 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 813020829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813020830 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 813020831 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 813020832 DNA binding site [nucleotide binding] 813020833 active site 813020834 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 813020835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813020836 dimer interface [polypeptide binding]; other site 813020837 conserved gate region; other site 813020838 putative PBP binding loops; other site 813020839 ABC-ATPase subunit interface; other site 813020840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 813020841 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 813020842 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 813020843 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 813020844 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 813020845 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 813020846 putative active site [active] 813020847 putative metal binding site [ion binding]; other site 813020848 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813020849 binding surface 813020850 TPR motif; other site 813020851 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 813020852 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 813020853 C-terminal domain interface [polypeptide binding]; other site 813020854 active site 813020855 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 813020856 active site 813020857 N-terminal domain interface [polypeptide binding]; other site 813020858 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 813020859 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 813020860 substrate binding pocket [chemical binding]; other site 813020861 membrane-bound complex binding site; other site 813020862 hinge residues; other site 813020863 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 813020864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813020865 S-adenosylmethionine binding site [chemical binding]; other site 813020866 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 813020867 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813020868 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 813020869 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 813020870 ligand binding site; other site 813020871 oligomer interface; other site 813020872 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 813020873 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 813020874 N-terminal domain interface [polypeptide binding]; other site 813020875 sulfate 1 binding site; other site 813020876 transcription termination factor Rho; Region: rho; TIGR00767 813020877 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 813020878 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 813020879 RNA binding site [nucleotide binding]; other site 813020880 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 813020881 multimer interface [polypeptide binding]; other site 813020882 Walker A motif; other site 813020883 ATP binding site [chemical binding]; other site 813020884 Walker B motif; other site 813020885 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 813020886 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 813020887 CoA-binding site [chemical binding]; other site 813020888 ATP-binding [chemical binding]; other site 813020889 DNA polymerase I; Provisional; Region: PRK05755 813020890 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 813020891 active site 813020892 metal binding site 1 [ion binding]; metal-binding site 813020893 putative 5' ssDNA interaction site; other site 813020894 metal binding site 3; metal-binding site 813020895 metal binding site 2 [ion binding]; metal-binding site 813020896 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 813020897 putative DNA binding site [nucleotide binding]; other site 813020898 putative metal binding site [ion binding]; other site 813020899 3'-5' exonuclease; Region: 35EXOc; smart00474 813020900 active site 813020901 substrate binding site [chemical binding]; other site 813020902 catalytic site [active] 813020903 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 813020904 active site 813020905 DNA binding site [nucleotide binding] 813020906 catalytic site [active] 813020907 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 813020908 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 813020909 tandem repeat interface [polypeptide binding]; other site 813020910 oligomer interface [polypeptide binding]; other site 813020911 active site residues [active] 813020912 TLC ATP/ADP transporter; Region: TLC; pfam03219 813020913 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 813020914 replicative DNA helicase; Provisional; Region: PRK06321 813020915 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 813020916 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 813020917 Walker A motif; other site 813020918 ATP binding site [chemical binding]; other site 813020919 Walker B motif; other site 813020920 DNA binding loops [nucleotide binding] 813020921 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 813020922 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 813020923 RuvA N terminal domain; Region: RuvA_N; pfam01330 813020924 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 813020925 active site 813020926 putative DNA-binding cleft [nucleotide binding]; other site 813020927 dimer interface [polypeptide binding]; other site 813020928 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 813020929 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 813020930 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 813020931 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 813020932 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 813020933 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 813020934 alphaNTD - beta interaction site [polypeptide binding]; other site 813020935 alphaNTD homodimer interface [polypeptide binding]; other site 813020936 alphaNTD - beta' interaction site [polypeptide binding]; other site 813020937 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 813020938 30S ribosomal protein S11; Validated; Region: PRK05309 813020939 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 813020940 30S ribosomal protein S13; Region: bact_S13; TIGR03631 813020941 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 813020942 SecY translocase; Region: SecY; pfam00344 813020943 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 813020944 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 813020945 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 813020946 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 813020947 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 813020948 5S rRNA interface [nucleotide binding]; other site 813020949 23S rRNA interface [nucleotide binding]; other site 813020950 L5 interface [polypeptide binding]; other site 813020951 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 813020952 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 813020953 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 813020954 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 813020955 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 813020956 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 813020957 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 813020958 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 813020959 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 813020960 RNA binding site [nucleotide binding]; other site 813020961 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 813020962 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 813020963 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 813020964 23S rRNA interface [nucleotide binding]; other site 813020965 putative translocon interaction site; other site 813020966 signal recognition particle (SRP54) interaction site; other site 813020967 L23 interface [polypeptide binding]; other site 813020968 trigger factor interaction site; other site 813020969 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 813020970 23S rRNA interface [nucleotide binding]; other site 813020971 5S rRNA interface [nucleotide binding]; other site 813020972 putative antibiotic binding site [chemical binding]; other site 813020973 L25 interface [polypeptide binding]; other site 813020974 L27 interface [polypeptide binding]; other site 813020975 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 813020976 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 813020977 G-X-X-G motif; other site 813020978 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 813020979 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 813020980 putative translocon binding site; other site 813020981 protein-rRNA interface [nucleotide binding]; other site 813020982 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 813020983 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 813020984 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 813020985 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 813020986 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 813020987 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 813020988 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 813020989 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 813020990 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 813020991 putative active site [active] 813020992 substrate binding site [chemical binding]; other site 813020993 putative cosubstrate binding site; other site 813020994 catalytic site [active] 813020995 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 813020996 substrate binding site [chemical binding]; other site 813020997 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 813020998 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 813020999 active site 813021000 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 813021001 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 813021002 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 813021003 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 813021004 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 813021005 putative active site [active] 813021006 catalytic triad [active] 813021007 putative dimer interface [polypeptide binding]; other site 813021008 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 813021009 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 813021010 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 813021011 active site 813021012 catalytic site [active] 813021013 substrate binding site [chemical binding]; other site 813021014 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 813021015 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 813021016 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 813021017 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 813021018 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813021019 catalytic residues [active] 813021020 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 813021021 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 813021022 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 813021023 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 813021024 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 813021025 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 813021026 dimer interface [polypeptide binding]; other site 813021027 anticodon binding site; other site 813021028 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 813021029 homodimer interface [polypeptide binding]; other site 813021030 motif 1; other site 813021031 active site 813021032 motif 2; other site 813021033 GAD domain; Region: GAD; pfam02938 813021034 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813021035 active site 813021036 motif 3; other site 813021037 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 813021038 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 813021039 dimer interface [polypeptide binding]; other site 813021040 motif 1; other site 813021041 active site 813021042 motif 2; other site 813021043 motif 3; other site 813021044 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 813021045 anticodon binding site; other site 813021046 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 813021047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813021048 putative substrate translocation pore; other site 813021049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813021050 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 813021051 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 813021052 active site 813021053 PHP Thumb interface [polypeptide binding]; other site 813021054 metal binding site [ion binding]; metal-binding site 813021055 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 813021056 generic binding surface I; other site 813021057 generic binding surface II; other site 813021058 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 813021059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 813021060 Mg2+ binding site [ion binding]; other site 813021061 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 813021062 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 813021063 branched-chain amino acid uptake carrier; Region: livcs; TIGR00796 813021064 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 813021065 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 813021066 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 813021067 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 813021068 lipoate synthase; Region: lipA; TIGR00510 813021069 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813021070 FeS/SAM binding site; other site 813021071 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 813021072 type III secretion system protein; Validated; Region: PRK06328 813021073 Flagellar assembly protein FliH; Region: FliH; pfam02108 813021074 type III secretion system protein; Reviewed; Region: PRK09617 813021075 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 813021076 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 813021077 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 813021078 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 813021079 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 813021080 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 813021081 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 813021082 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 813021083 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 813021084 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 813021085 Walker A motif; other site 813021086 ATP binding site [chemical binding]; other site 813021087 Walker B motif; other site 813021088 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 813021089 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813021090 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 813021091 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 813021092 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 813021093 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 813021094 active site 813021095 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 813021096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813021097 ATP binding site [chemical binding]; other site 813021098 Mg2+ binding site [ion binding]; other site 813021099 G-X-G motif; other site 813021100 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 813021101 ATP binding site [chemical binding]; other site 813021102 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 813021103 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 813021104 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813021105 binding surface 813021106 TPR motif; other site 813021107 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 813021108 EamA-like transporter family; Region: EamA; pfam00892 813021109 EamA-like transporter family; Region: EamA; pfam00892 813021110 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 813021111 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cd01616 813021112 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 813021113 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 813021114 active site 813021115 dimer interface [polypeptide binding]; other site 813021116 motif 1; other site 813021117 motif 2; other site 813021118 motif 3; other site 813021119 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 813021120 anticodon binding site; other site 813021121 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 813021122 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 813021123 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 813021124 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 813021125 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 813021126 active site 813021127 HIGH motif; other site 813021128 dimer interface [polypeptide binding]; other site 813021129 KMSKS motif; other site 813021130 excinuclease ABC subunit B; Provisional; Region: PRK05298 813021131 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813021132 ATP binding site [chemical binding]; other site 813021133 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813021134 nucleotide binding region [chemical binding]; other site 813021135 ATP-binding site [chemical binding]; other site 813021136 Ultra-violet resistance protein B; Region: UvrB; pfam12344 813021137 enolase; Provisional; Region: eno; PRK00077 813021138 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 813021139 dimer interface [polypeptide binding]; other site 813021140 metal binding site [ion binding]; metal-binding site 813021141 substrate binding pocket [chemical binding]; other site 813021142 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 813021143 HAMP domain; Region: HAMP; pfam00672 813021144 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 813021145 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 813021146 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 813021147 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 813021148 proximal heme binding site [chemical binding]; other site 813021149 Iron-sulfur protein interface; other site 813021150 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 813021151 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 813021152 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 813021153 active site 813021154 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 813021155 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 813021156 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 813021157 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 813021158 DsbD alpha interface [polypeptide binding]; other site 813021159 catalytic residues [active] 813021160 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 813021161 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 813021162 translocation protein TolB; Provisional; Region: tolB; PRK01029 813021163 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813021164 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813021165 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813021166 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 813021167 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 813021168 ligand binding site [chemical binding]; other site 813021169 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 813021170 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813021171 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 813021172 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 813021173 dimer interface [polypeptide binding]; other site 813021174 decamer (pentamer of dimers) interface [polypeptide binding]; other site 813021175 catalytic triad [active] 813021176 peroxidatic and resolving cysteines [active] 813021177 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 813021178 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 813021179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 813021180 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 813021181 active site 813021182 dimerization interface [polypeptide binding]; other site 813021183 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 813021184 ligand binding site [chemical binding]; other site 813021185 active site 813021186 UGI interface [polypeptide binding]; other site 813021187 catalytic site [active] 813021188 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 813021189 Part of AAA domain; Region: AAA_19; pfam13245 813021190 Family description; Region: UvrD_C_2; pfam13538 813021191 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 813021192 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 813021193 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 813021194 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 813021195 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 813021196 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 813021197 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 813021198 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 813021199 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 813021200 folate binding site [chemical binding]; other site 813021201 NADP+ binding site [chemical binding]; other site 813021202 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 813021203 catalytic center binding site [active] 813021204 ATP binding site [chemical binding]; other site 813021205 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 813021206 dihydropteroate synthase; Region: DHPS; TIGR01496 813021207 substrate binding pocket [chemical binding]; other site 813021208 dimer interface [polypeptide binding]; other site 813021209 inhibitor binding site; inhibition site 813021210 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 813021211 homooctamer interface [polypeptide binding]; other site 813021212 active site 813021213 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 813021214 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 813021215 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 813021216 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 813021217 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 813021218 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 813021219 DNA binding residues [nucleotide binding] 813021220 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 813021221 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 813021222 Effector from type III secretion system; Region: Effector_1; pfam04518 813021223 Effector from type III secretion system; Region: Effector_1; pfam04518 813021224 Effector from type III secretion system; Region: Effector_1; pfam04518 813021225 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 813021226 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 813021227 MviN-like protein; Region: MVIN; pfam03023 813021228 endonuclease IV; Provisional; Region: PRK01060 813021229 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 813021230 AP (apurinic/apyrimidinic) site pocket; other site 813021231 DNA interaction; other site 813021232 Metal-binding active site; metal-binding site 813021233 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 813021234 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 813021235 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813021236 RNA binding surface [nucleotide binding]; other site 813021237 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 813021238 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 813021239 active site residue [active] 813021240 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 813021241 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 813021242 substrate binding pocket [chemical binding]; other site 813021243 chain length determination region; other site 813021244 substrate-Mg2+ binding site; other site 813021245 catalytic residues [active] 813021246 aspartate-rich region 1; other site 813021247 active site lid residues [active] 813021248 aspartate-rich region 2; other site 813021249 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 813021250 putative trimer interface [polypeptide binding]; other site 813021251 putative CoA binding site [chemical binding]; other site 813021252 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 813021253 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 813021254 DNA binding site [nucleotide binding] 813021255 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 813021256 Thymidylate synthase complementing protein; Region: Thy1; cl03630 813021257 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 813021258 dimer interface [polypeptide binding]; other site 813021259 active site 813021260 aspartate-rich active site metal binding site; other site 813021261 allosteric magnesium binding site [ion binding]; other site 813021262 Schiff base residues; other site 813021263 NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit; Region: nqrA; TIGR01936 813021264 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 813021265 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 813021266 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 813021267 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 813021268 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 813021269 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 813021270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813021271 homodimer interface [polypeptide binding]; other site 813021272 catalytic residue [active] 813021273 rod shape-determining protein MreC; Provisional; Region: PRK14872 813021274 rod shape-determining protein MreC; Region: MreC; pfam04085 813021275 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 813021276 Part of AAA domain; Region: AAA_19; pfam13245 813021277 Family description; Region: UvrD_C_2; pfam13538 813021278 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 813021279 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 813021280 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 813021281 active site 813021282 interdomain interaction site; other site 813021283 putative metal-binding site [ion binding]; other site 813021284 nucleotide binding site [chemical binding]; other site 813021285 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 813021286 domain I; other site 813021287 DNA binding groove [nucleotide binding] 813021288 phosphate binding site [ion binding]; other site 813021289 domain II; other site 813021290 domain III; other site 813021291 nucleotide binding site [chemical binding]; other site 813021292 catalytic site [active] 813021293 domain IV; other site 813021294 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813021295 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813021296 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813021297 SWI complex, BAF60b domains; Region: SWIB; smart00151 813021298 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 813021299 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 813021300 FMN binding site [chemical binding]; other site 813021301 active site 813021302 catalytic residues [active] 813021303 substrate binding site [chemical binding]; other site 813021304 Predicted integral membrane protein [Function unknown]; Region: COG0762 813021305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813021306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813021307 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 813021308 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 813021309 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 813021310 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 813021311 AAA domain; Region: AAA_30; pfam13604 813021312 Family description; Region: UvrD_C_2; pfam13538 813021313 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 813021314 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 813021315 Walker A/P-loop; other site 813021316 ATP binding site [chemical binding]; other site 813021317 Q-loop/lid; other site 813021318 ABC transporter signature motif; other site 813021319 Walker B; other site 813021320 D-loop; other site 813021321 H-loop/switch region; other site 813021322 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 813021323 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 813021324 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 813021325 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 813021326 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813021327 RNA binding surface [nucleotide binding]; other site 813021328 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 813021329 active site 813021330 hypothetical protein; Provisional; Region: PRK01064 813021331 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 813021332 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 813021333 DNA Topoisomerase IV; Region: TOP4c; smart00434 813021334 CAP-like domain; other site 813021335 active site 813021336 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 813021337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813021338 ATP binding site [chemical binding]; other site 813021339 Mg2+ binding site [ion binding]; other site 813021340 G-X-G motif; other site 813021341 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 813021342 ATP binding site [chemical binding]; other site 813021343 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 813021344 active site 813021345 putative metal-binding site [ion binding]; other site 813021346 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 813021347 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813021348 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 813021349 phosphopeptide binding site; other site 813021350 MARCKS family; Region: MARCKS; pfam02063 813021351 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 813021352 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 813021353 phosphopeptide binding site; other site 813021354 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 813021355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 813021356 binding surface 813021357 Tetratricopeptide repeat; Region: TPR_16; pfam13432 813021358 TPR motif; other site 813021359 type III secretion system ATPase; Provisional; Region: PRK06315 813021360 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813021361 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 813021362 Walker A motif/ATP binding site; other site 813021363 Walker B motif; other site 813021364 type III secretion system protein; Validated; Region: PRK05933 813021365 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 813021366 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 813021367 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813021368 active site 813021369 ATP binding site [chemical binding]; other site 813021370 substrate binding site [chemical binding]; other site 813021371 activation loop (A-loop); other site 813021372 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 813021373 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813021374 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813021375 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 813021376 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 813021377 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 813021378 ADP binding site [chemical binding]; other site 813021379 phosphagen binding site; other site 813021380 substrate specificity loop; other site 813021381 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 813021382 UvrB/uvrC motif; Region: UVR; pfam02151 813021383 ribosome recycling factor; Reviewed; Region: frr; PRK00083 813021384 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 813021385 hinge region; other site 813021386 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 813021387 putative nucleotide binding site [chemical binding]; other site 813021388 uridine monophosphate binding site [chemical binding]; other site 813021389 homohexameric interface [polypeptide binding]; other site 813021390 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 813021391 rRNA interaction site [nucleotide binding]; other site 813021392 S8 interaction site; other site 813021393 putative laminin-1 binding site; other site 813021394 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 813021395 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 813021396 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 813021397 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 813021398 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 813021399 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813021400 TPR motif; other site 813021401 Tetratricopeptide repeat; Region: TPR_16; pfam13432 813021402 binding surface 813021403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813021404 binding surface 813021405 TPR motif; other site 813021406 TPR repeat; Region: TPR_11; pfam13414 813021407 TPR repeat; Region: TPR_11; pfam13414 813021408 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813021409 binding surface 813021410 TPR motif; other site 813021411 TPR repeat; Region: TPR_11; pfam13414 813021412 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 813021413 putative ABC transporter; Region: ycf24; CHL00085 813021414 FeS assembly ATPase SufC; Region: sufC; TIGR01978 813021415 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 813021416 Walker A/P-loop; other site 813021417 ATP binding site [chemical binding]; other site 813021418 Q-loop/lid; other site 813021419 ABC transporter signature motif; other site 813021420 Walker B; other site 813021421 D-loop; other site 813021422 H-loop/switch region; other site 813021423 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 813021424 FeS assembly protein SufD; Region: sufD; TIGR01981 813021425 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 813021426 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 813021427 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813021428 catalytic residue [active] 813021429 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 813021430 ParB-like nuclease domain; Region: ParBc; pfam02195 813021431 KorB domain; Region: KorB; pfam08535 813021432 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813021433 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 813021434 Walker A/P-loop; other site 813021435 ATP binding site [chemical binding]; other site 813021436 Q-loop/lid; other site 813021437 ABC transporter signature motif; other site 813021438 Walker B; other site 813021439 D-loop; other site 813021440 H-loop/switch region; other site 813021441 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813021442 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 813021443 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813021444 Walker A/P-loop; other site 813021445 ATP binding site [chemical binding]; other site 813021446 Q-loop/lid; other site 813021447 ABC transporter signature motif; other site 813021448 Walker B; other site 813021449 D-loop; other site 813021450 H-loop/switch region; other site 813021451 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813021452 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 813021453 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 813021454 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 813021455 Phosphoglycerate kinase; Region: PGK; pfam00162 813021456 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 813021457 substrate binding site [chemical binding]; other site 813021458 hinge regions; other site 813021459 ADP binding site [chemical binding]; other site 813021460 catalytic site [active] 813021461 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 813021462 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 813021463 minor groove reading motif; other site 813021464 helix-hairpin-helix signature motif; other site 813021465 substrate binding pocket [chemical binding]; other site 813021466 active site 813021467 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 813021468 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 813021469 trmE is a tRNA modification GTPase; Region: trmE; cd04164 813021470 G1 box; other site 813021471 GTP/Mg2+ binding site [chemical binding]; other site 813021472 Switch I region; other site 813021473 G2 box; other site 813021474 Switch II region; other site 813021475 G3 box; other site 813021476 G4 box; other site 813021477 G5 box; other site 813021478 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 813021479 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 813021480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813021481 binding surface 813021482 TPR motif; other site 813021483 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 813021484 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 813021485 ATP binding site [chemical binding]; other site 813021486 putative Mg++ binding site [ion binding]; other site 813021487 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 813021488 Predicted GTPases [General function prediction only]; Region: COG1160 813021489 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 813021490 G1 box; other site 813021491 GTP/Mg2+ binding site [chemical binding]; other site 813021492 Switch I region; other site 813021493 G2 box; other site 813021494 Switch II region; other site 813021495 G3 box; other site 813021496 G4 box; other site 813021497 G5 box; other site 813021498 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 813021499 G1 box; other site 813021500 GTP/Mg2+ binding site [chemical binding]; other site 813021501 Switch I region; other site 813021502 G2 box; other site 813021503 G3 box; other site 813021504 Switch II region; other site 813021505 G4 box; other site 813021506 G5 box; other site 813021507 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 813021508 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 813021509 active site 813021510 NTP binding site [chemical binding]; other site 813021511 metal binding triad [ion binding]; metal-binding site 813021512 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 813021513 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 813021514 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 813021515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813021516 Walker A motif; other site 813021517 ATP binding site [chemical binding]; other site 813021518 Walker B motif; other site 813021519 arginine finger; other site 813021520 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 813021521 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 813021522 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 813021523 oligomer interface [polypeptide binding]; other site 813021524 active site residues [active] 813021525 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 813021526 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 813021527 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 813021528 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 813021529 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813021530 ATP binding site [chemical binding]; other site 813021531 putative Mg++ binding site [ion binding]; other site 813021532 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813021533 nucleotide binding region [chemical binding]; other site 813021534 ATP-binding site [chemical binding]; other site 813021535 rod shape-determining protein MreB; Provisional; Region: PRK13927 813021536 MreB and similar proteins; Region: MreB_like; cd10225 813021537 nucleotide binding site [chemical binding]; other site 813021538 Mg binding site [ion binding]; other site 813021539 putative protofilament interaction site [polypeptide binding]; other site 813021540 RodZ interaction site [polypeptide binding]; other site 813021541 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 813021542 active site 813021543 substrate-binding site [chemical binding]; other site 813021544 metal-binding site [ion binding] 813021545 GTP binding site [chemical binding]; other site 813021546 Effector from type III secretion system; Region: Effector_1; pfam04518 813021547 Effector from type III secretion system; Region: Effector_1; pfam04518 813021548 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 813021549 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 813021550 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 813021551 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 813021552 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 813021553 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 813021554 active site 813021555 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 813021556 type III secretion system ATPase; Validated; Region: PRK05922 813021557 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813021558 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 813021559 Walker A motif; other site 813021560 ATP binding site [chemical binding]; other site 813021561 Walker B motif; other site 813021562 type III secretion system protein; Validated; Region: PRK05934 813021563 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 813021564 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 813021565 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 813021566 active site 813021567 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 813021568 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 813021569 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813021570 catalytic residue [active] 813021571 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 813021572 catalytic core [active] 813021573 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 813021574 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813021575 RNA binding surface [nucleotide binding]; other site 813021576 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 813021577 active site 813021578 biotin--protein ligase; Provisional; Region: PRK05935 813021579 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 813021580 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 813021581 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 813021582 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 813021583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 813021584 motif II; other site 813021585 CCC1-related protein family; Region: CCC1_like_1; cd02437 813021586 seryl-tRNA synthetase; Provisional; Region: PRK05431 813021587 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 813021588 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 813021589 dimer interface [polypeptide binding]; other site 813021590 active site 813021591 motif 1; other site 813021592 motif 2; other site 813021593 motif 3; other site 813021594 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 813021595 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 813021596 catalytic motif [active] 813021597 Zn binding site [ion binding]; other site 813021598 RibD C-terminal domain; Region: RibD_C; pfam01872 813021599 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 813021600 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 813021601 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 813021602 dimerization interface [polypeptide binding]; other site 813021603 active site 813021604 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 813021605 homopentamer interface [polypeptide binding]; other site 813021606 active site 813021607 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 813021608 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 813021609 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 813021610 substrate binding site [chemical binding]; other site 813021611 Proteins containing SET domain [General function prediction only]; Region: COG2940 813021612 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 813021613 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 813021614 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 813021615 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 813021616 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 813021617 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 813021618 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 813021619 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 813021620 catalytic loop [active] 813021621 iron binding site [ion binding]; other site 813021622 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 813021623 FAD binding pocket [chemical binding]; other site 813021624 FAD binding motif [chemical binding]; other site 813021625 phosphate binding motif [ion binding]; other site 813021626 beta-alpha-beta structure motif; other site 813021627 NAD binding pocket [chemical binding]; other site 813021628 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 813021629 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 813021630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813021631 S-adenosylmethionine binding site [chemical binding]; other site 813021632 Histone H1-like protein Hc1; Region: Hc1; pfam07432 813021633 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 813021634 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 813021635 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 813021636 HemN C-terminal domain; Region: HemN_C; pfam06969 813021637 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 813021638 substrate binding site [chemical binding]; other site 813021639 active site 813021640 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 813021641 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 813021642 motif 1; other site 813021643 active site 813021644 motif 2; other site 813021645 motif 3; other site 813021646 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 813021647 DHHA1 domain; Region: DHHA1; pfam02272 813021648 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 813021649 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 813021650 TPP-binding site [chemical binding]; other site 813021651 dimer interface [polypeptide binding]; other site 813021652 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 813021653 PYR/PP interface [polypeptide binding]; other site 813021654 dimer interface [polypeptide binding]; other site 813021655 TPP binding site [chemical binding]; other site 813021656 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813021657 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 813021658 elongation factor P; Validated; Region: PRK00529 813021659 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 813021660 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 813021661 RNA binding site [nucleotide binding]; other site 813021662 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 813021663 RNA binding site [nucleotide binding]; other site 813021664 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813021665 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 813021666 putative active site [active] 813021667 putative metal binding site [ion binding]; other site 813021668 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 813021669 active site 813021670 metal binding site [ion binding]; metal-binding site 813021671 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 813021672 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 813021673 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 813021674 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813021675 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813021676 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 813021677 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 813021678 Mg++ binding site [ion binding]; other site 813021679 putative catalytic motif [active] 813021680 putative substrate binding site [chemical binding]; other site 813021681 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 813021682 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 813021683 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813021684 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813021685 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 813021686 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813021687 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813021688 cell division protein FtsW; Region: ftsW; TIGR02614 813021689 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 813021690 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409 813021691 G-X-X-G motif; other site 813021692 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 813021693 anti sigma factor interaction site; other site 813021694 regulatory phosphorylation site [posttranslational modification]; other site 813021695 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 813021696 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 813021697 hypothetical protein; Provisional; Region: PRK05927 813021698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 813021699 FeS/SAM binding site; other site 813021700 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813021701 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 813021702 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 813021703 active site 813021704 Ap4A binding cleft/pocket [chemical binding]; other site 813021705 P4 phosphate binding site; other site 813021706 nudix motif; other site 813021707 putative P2/P3 phosphate binding site [ion binding]; other site 813021708 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 813021709 dimer interface [polypeptide binding]; other site 813021710 substrate binding site [chemical binding]; other site 813021711 metal binding sites [ion binding]; metal-binding site 813021712 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 813021713 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 813021714 active site 813021715 putative lithium-binding site [ion binding]; other site 813021716 substrate binding site [chemical binding]; other site 813021717 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 813021718 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 813021719 putative acyl-acceptor binding pocket; other site 813021720 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 813021721 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 813021722 acyl-activating enzyme (AAE) consensus motif; other site 813021723 AMP binding site [chemical binding]; other site 813021724 active site 813021725 CoA binding site [chemical binding]; other site 813021726 8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937 813021727 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 813021728 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813021729 catalytic residue [active] 813021730 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 813021731 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813021732 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 813021733 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 813021734 dimer interface [polypeptide binding]; other site 813021735 putative anticodon binding site; other site 813021736 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813021737 motif 1; other site 813021738 dimer interface [polypeptide binding]; other site 813021739 active site 813021740 motif 2; other site 813021741 motif 3; other site 813021742 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 813021743 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 813021744 active site 813021745 HIGH motif; other site 813021746 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 813021747 KMSKS motif; other site 813021748 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813021749 tRNA binding surface [nucleotide binding]; other site 813021750 anticodon binding site; other site 813021751 ribonuclease P; Reviewed; Region: rnpA; PRK00730 813021752 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 813021753 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 813021754 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 813021755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 813021756 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 813021757 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 813021758 GIY-YIG motif/motif A; other site 813021759 active site 813021760 catalytic site [active] 813021761 putative DNA binding site [nucleotide binding]; other site 813021762 metal binding site [ion binding]; metal-binding site 813021763 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 813021764 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 813021765 MutS domain I; Region: MutS_I; pfam01624 813021766 MutS domain II; Region: MutS_II; pfam05188 813021767 MutS domain III; Region: MutS_III; pfam05192 813021768 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 813021769 Walker A/P-loop; other site 813021770 ATP binding site [chemical binding]; other site 813021771 Q-loop/lid; other site 813021772 ABC transporter signature motif; other site 813021773 Walker B; other site 813021774 D-loop; other site 813021775 H-loop/switch region; other site 813021776 DNA primase; Validated; Region: dnaG; PRK05667 813021777 CHC2 zinc finger; Region: zf-CHC2; pfam01807 813021778 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 813021779 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 813021780 active site 813021781 metal binding site [ion binding]; metal-binding site 813021782 interdomain interaction site; other site 813021783 glycyl-tRNA synthetase; Provisional; Region: PRK14908 813021784 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 813021785 dimer interface [polypeptide binding]; other site 813021786 motif 1; other site 813021787 active site 813021788 motif 2; other site 813021789 motif 3; other site 813021790 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813021791 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 813021792 glycogen synthase; Provisional; Region: glgA; PRK00654 813021793 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 813021794 ADP-binding pocket [chemical binding]; other site 813021795 homodimer interface [polypeptide binding]; other site 813021796 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 813021797 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 813021798 5S rRNA interface [nucleotide binding]; other site 813021799 CTC domain interface [polypeptide binding]; other site 813021800 L16 interface [polypeptide binding]; other site 813021801 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 813021802 putative active site [active] 813021803 catalytic residue [active] 813021804 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 813021805 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 813021806 Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359 813021807 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 813021808 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 813021809 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 813021810 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 813021811 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 813021812 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813021813 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813021814 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 813021815 putative acyl-acceptor binding pocket; other site 813021816 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 813021817 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 813021818 homodimer interface [polypeptide binding]; other site 813021819 oligonucleotide binding site [chemical binding]; other site 813021820 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 813021821 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 813021822 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813021823 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813021824 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 813021825 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 813021826 active site 813021827 substrate binding site [chemical binding]; other site 813021828 metal binding site [ion binding]; metal-binding site 813021829 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 813021830 aromatic amino acid transport protein; Region: araaP; TIGR00837 813021831 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 813021832 aromatic amino acid transport protein; Region: araaP; TIGR00837 813021833 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 813021834 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 813021835 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 813021836 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 813021837 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 813021838 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 813021839 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 813021840 CoA-ligase; Region: Ligase_CoA; pfam00549 813021841 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 813021842 CoA binding domain; Region: CoA_binding; smart00881 813021843 CoA-ligase; Region: Ligase_CoA; pfam00549 813021844 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 813021845 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 813021846 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 813021847 protein binding site [polypeptide binding]; other site 813021848 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 813021849 protein binding site [polypeptide binding]; other site 813021850 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 813021851 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 813021852 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813021853 Peptidase M16C associated; Region: M16C_assoc; pfam08367 813021854 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813021855 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 813021856 RmuC family; Region: RmuC; pfam02646 813021857 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 813021858 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 813021859 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 813021860 ATP cone domain; Region: ATP-cone; pfam03477 813021861 ATP cone domain; Region: ATP-cone; pfam03477 813021862 Class I ribonucleotide reductase; Region: RNR_I; cd01679 813021863 active site 813021864 dimer interface [polypeptide binding]; other site 813021865 catalytic residues [active] 813021866 effector binding site; other site 813021867 R2 peptide binding site; other site 813021868 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 813021869 dimer interface [polypeptide binding]; other site 813021870 putative radical transfer pathway; other site 813021871 diiron center [ion binding]; other site 813021872 tyrosyl radical; other site 813021873 Putative methyltransferase; Region: Methyltransf_4; pfam02390 813021874 Methyltransferase domain; Region: Methyltransf_18; pfam12847 813021875 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 813021876 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 813021877 FAD binding domain; Region: FAD_binding_4; pfam01565 813021878 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 813021879 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 813021880 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 813021881 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 813021882 Ribosomal protein L35 [Translation, ribosomal structure and biogenesis]; Region: RpmI; COG0291 813021883 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 813021884 23S rRNA binding site [nucleotide binding]; other site 813021885 L21 binding site [polypeptide binding]; other site 813021886 L13 binding site [polypeptide binding]; other site 813021887 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 813021888 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 813021889 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 813021890 motif 1; other site 813021891 dimer interface [polypeptide binding]; other site 813021892 active site 813021893 motif 2; other site 813021894 motif 3; other site 813021895 Predicted permeases [General function prediction only]; Region: COG0795 813021896 Predicted permeases [General function prediction only]; Region: COG0795 813021897 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 813021898 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 813021899 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 813021900 Ligand Binding Site [chemical binding]; other site 813021901 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 813021902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813021903 Walker A motif; other site 813021904 ATP binding site [chemical binding]; other site 813021905 Walker B motif; other site 813021906 arginine finger; other site 813021907 Peptidase family M41; Region: Peptidase_M41; pfam01434 813021908 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 813021909 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 813021910 RNase E interface [polypeptide binding]; other site 813021911 trimer interface [polypeptide binding]; other site 813021912 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 813021913 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 813021914 RNase E interface [polypeptide binding]; other site 813021915 trimer interface [polypeptide binding]; other site 813021916 active site 813021917 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 813021918 putative nucleic acid binding region [nucleotide binding]; other site 813021919 G-X-X-G motif; other site 813021920 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 813021921 RNA binding site [nucleotide binding]; other site 813021922 domain interface; other site 813021923 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 813021924 16S/18S rRNA binding site [nucleotide binding]; other site 813021925 S13e-L30e interaction site [polypeptide binding]; other site 813021926 25S rRNA binding site [nucleotide binding]; other site 813021927 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 813021928 nucleoside/Zn binding site; other site 813021929 dimer interface [polypeptide binding]; other site 813021930 catalytic motif [active] 813021931 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813021932 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813021933 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813021934 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813021935 methionine aminopeptidase; Provisional; Region: PRK12318 813021936 SEC-C motif; Region: SEC-C; pfam02810 813021937 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 813021938 active site 813021939 MarC family integral membrane protein; Region: MarC; pfam01914 813021940 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 813021941 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 813021942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813021943 dimer interface [polypeptide binding]; other site 813021944 conserved gate region; other site 813021945 putative PBP binding loops; other site 813021946 ABC-ATPase subunit interface; other site 813021947 NMT1/THI5 like; Region: NMT1; pfam09084 813021948 fumarate hydratase, class II; Region: fumC_II; TIGR00979 813021949 Class II fumarases; Region: Fumarase_classII; cd01362 813021950 active site 813021951 tetramer interface [polypeptide binding]; other site 813021952 high affinity sulphate transporter 1; Region: sulP; TIGR00815 813021953 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 813021954 Sulfate transporter family; Region: Sulfate_transp; pfam00916 813021955 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 813021956 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 813021957 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 813021958 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 813021959 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 813021960 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 813021961 active site triad [active] 813021962 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 813021963 LytB protein; Region: LYTB; pfam02401 813021964 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 813021965 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 813021966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813021967 binding surface 813021968 TPR motif; other site 813021969 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 813021970 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 813021971 active site 813021972 DNA binding site [nucleotide binding] 813021973 Int/Topo IB signature motif; other site 813021974 glycogen branching enzyme; Provisional; Region: PRK05402 813021975 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 813021976 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 813021977 active site 813021978 catalytic site [active] 813021979 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 813021980 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 813021981 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813021982 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813021983 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813021984 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813021985 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813021986 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813021987 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813021988 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813021989 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813021990 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813021991 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813021992 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813021993 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813021994 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813021995 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813021996 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813021997 Uncharacterized conserved protein [Function unknown]; Region: COG2155 813021998 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 813021999 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 813022000 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 813022001 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 813022002 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 813022003 GatB domain; Region: GatB_Yqey; pfam02637 813022004 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 813022005 ribonuclease HIII; Region: rnhC; TIGR00716 813022006 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 813022007 RNA/DNA hybrid binding site [nucleotide binding]; other site 813022008 active site 813022009 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 813022010 Helix-turn-helix domain; Region: HTH_25; pfam13413 813022011 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906 813022012 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 813022013 putative acyl-acceptor binding pocket; other site 813022014 Uncharacterized conserved protein [Function unknown]; Region: COG1624 813022015 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 813022016 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 813022017 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 813022018 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 813022019 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 813022020 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 813022021 putative active site [active] 813022022 PhoH-like protein; Region: PhoH; pfam02562 813022023 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 813022024 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 813022025 HIGH motif; other site 813022026 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 813022027 active site 813022028 KMSKS motif; other site 813022029 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 813022030 tRNA binding surface [nucleotide binding]; other site 813022031 anticodon binding site; other site 813022032 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 813022033 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 813022034 Catalytic site [active] 813022035 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 813022036 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 813022037 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 813022038 peptide chain release factor 1; Validated; Region: prfA; PRK00591 813022039 PCRF domain; Region: PCRF; pfam03462 813022040 RF-1 domain; Region: RF-1; pfam00472 813022041 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 813022042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813022043 S-adenosylmethionine binding site [chemical binding]; other site 813022044 signal recognition particle protein; Provisional; Region: PRK10867 813022045 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 813022046 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 813022047 P loop; other site 813022048 GTP binding site [chemical binding]; other site 813022049 Signal peptide binding domain; Region: SRP_SPB; pfam02978 813022050 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 813022051 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 813022052 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 813022053 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 813022054 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 813022055 RNA/DNA hybrid binding site [nucleotide binding]; other site 813022056 active site 813022057 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 813022058 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 813022059 catalytic site [active] 813022060 G-X2-G-X-G-K; other site 813022061 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 813022062 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 813022063 active site 813022064 HIGH motif; other site 813022065 KMSKS motif; other site 813022066 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 813022067 tRNA binding surface [nucleotide binding]; other site 813022068 anticodon binding site; other site 813022069 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 813022070 AAA domain; Region: AAA_30; pfam13604 813022071 Family description; Region: UvrD_C_2; pfam13538 813022072 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 813022073 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 813022074 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 813022075 conserved cys residue [active] 813022076 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 813022077 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 813022078 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 813022079 trimer interface [polypeptide binding]; other site 813022080 active site 813022081 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 813022082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813022083 Walker A motif; other site 813022084 ATP binding site [chemical binding]; other site 813022085 Walker B motif; other site 813022086 arginine finger; other site 813022087 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 813022088 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813022089 multifunctional aminopeptidase A; Provisional; Region: PRK00913 813022090 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 813022091 interface (dimer of trimers) [polypeptide binding]; other site 813022092 Substrate-binding/catalytic site; other site 813022093 Zn-binding sites [ion binding]; other site 813022094 hypothetical protein; Provisional; Region: PRK05907 813022095 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 813022096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813022097 FeS/SAM binding site; other site 813022098 HemN C-terminal domain; Region: HemN_C; pfam06969 813022099 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 813022100 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 813022101 TPP-binding site [chemical binding]; other site 813022102 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 813022103 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 813022104 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813022105 E3 interaction surface; other site 813022106 lipoyl attachment site [posttranslational modification]; other site 813022107 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813022108 IncA protein; Region: IncA; pfam04156 813022109 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 813022110 ADP-ribose binding site [chemical binding]; other site 813022111 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 813022112 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 813022113 catalytic loop [active] 813022114 iron binding site [ion binding]; other site 813022115 type III secretion system protein; Validated; Region: PRK05910 813022116 FHIPEP family; Region: FHIPEP; pfam00771 813022117 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 813022118 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 813022119 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 813022120 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 813022121 DNA binding residues [nucleotide binding] 813022122 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 813022123 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 813022124 active site 813022125 HIGH motif; other site 813022126 dimer interface [polypeptide binding]; other site 813022127 KMSKS motif; other site 813022128 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813022129 RNA binding surface [nucleotide binding]; other site 813022130 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 813022131 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 813022132 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 813022133 GTP-binding protein LepA; Provisional; Region: PRK05433 813022134 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 813022135 G1 box; other site 813022136 putative GEF interaction site [polypeptide binding]; other site 813022137 GTP/Mg2+ binding site [chemical binding]; other site 813022138 Switch I region; other site 813022139 G2 box; other site 813022140 G3 box; other site 813022141 Switch II region; other site 813022142 G4 box; other site 813022143 G5 box; other site 813022144 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 813022145 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 813022146 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 813022147 ADP/ATP carrier protein family; Region: AAA; TIGR00769 813022148 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 813022149 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 813022150 intersubunit interface [polypeptide binding]; other site 813022151 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 813022152 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 813022153 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813022154 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813022155 ABC-ATPase subunit interface; other site 813022156 dimer interface [polypeptide binding]; other site 813022157 putative PBP binding regions; other site 813022158 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 813022159 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 813022160 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813022161 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813022162 ABC-ATPase subunit interface; other site 813022163 dimer interface [polypeptide binding]; other site 813022164 putative PBP binding regions; other site 813022165 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 813022166 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 813022167 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 813022168 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 813022169 RIP metalloprotease RseP; Region: TIGR00054 813022170 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 813022171 active site 813022172 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 813022173 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 813022174 putative substrate binding region [chemical binding]; other site 813022175 recF protein; Region: recf; TIGR00611 813022176 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813022177 Walker A/P-loop; other site 813022178 ATP binding site [chemical binding]; other site 813022179 Q-loop/lid; other site 813022180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813022181 ABC transporter signature motif; other site 813022182 Walker B; other site 813022183 DNA polymerase III subunit beta; Validated; Region: PRK05643 813022184 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 813022185 putative DNA binding surface [nucleotide binding]; other site 813022186 dimer interface [polypeptide binding]; other site 813022187 beta-clamp/clamp loader binding surface; other site 813022188 beta-clamp/translesion DNA polymerase binding surface; other site 813022189 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 813022190 SmpB-tmRNA interface; other site 813022191 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 813022192 ApbE family; Region: ApbE; pfam02424 813022193 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 813022194 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 813022195 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 813022196 homodimer interface [polypeptide binding]; other site 813022197 NADP binding site [chemical binding]; other site 813022198 substrate binding site [chemical binding]; other site 813022199 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813022200 PLD-like domain; Region: PLDc_2; pfam13091 813022201 putative active site [active] 813022202 catalytic site [active] 813022203 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813022204 PLD-like domain; Region: PLDc_2; pfam13091 813022205 putative active site [active] 813022206 catalytic site [active] 813022207 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 813022208 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 813022209 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 813022210 4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446 813022211 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813022212 HrpJ-like domain; Region: HrpJ; pfam07201 813022213 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 813022214 FHIPEP family; Region: FHIPEP; pfam00771 813022215 type III secretion system protein; Validated; Region: PRK06298 813022216 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 813022217 GTP-binding protein YchF; Reviewed; Region: PRK09601 813022218 YchF GTPase; Region: YchF; cd01900 813022219 G1 box; other site 813022220 GTP/Mg2+ binding site [chemical binding]; other site 813022221 Switch I region; other site 813022222 G2 box; other site 813022223 Switch II region; other site 813022224 G3 box; other site 813022225 G4 box; other site 813022226 G5 box; other site 813022227 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 813022228 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 813022229 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 813022230 active site 813022231 Riboflavin kinase; Region: Flavokinase; smart00904 813022232 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 813022233 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 813022234 RNA binding site [nucleotide binding]; other site 813022235 active site 813022236 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 813022237 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 813022238 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 813022239 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 813022240 G1 box; other site 813022241 putative GEF interaction site [polypeptide binding]; other site 813022242 GTP/Mg2+ binding site [chemical binding]; other site 813022243 Switch I region; other site 813022244 G2 box; other site 813022245 G3 box; other site 813022246 Switch II region; other site 813022247 G4 box; other site 813022248 G5 box; other site 813022249 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 813022250 Translation-initiation factor 2; Region: IF-2; pfam11987 813022251 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 813022252 transcription termination factor NusA; Region: NusA; TIGR01953 813022253 NusA N-terminal domain; Region: NusA_N; pfam08529 813022254 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 813022255 RNA binding site [nucleotide binding]; other site 813022256 homodimer interface [polypeptide binding]; other site 813022257 NusA-like KH domain; Region: KH_5; pfam13184 813022258 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 813022259 G-X-X-G motif; other site 813022260 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 813022261 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 813022262 RNA binding site [nucleotide binding]; other site 813022263 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 813022264 RNA binding site [nucleotide binding]; other site 813022265 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813022266 RNA binding site [nucleotide binding]; other site 813022267 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813022268 RNA binding site [nucleotide binding]; other site 813022269 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 813022270 RNA binding site [nucleotide binding]; other site 813022271 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 813022272 RNA binding site [nucleotide binding]; other site 813022273 domain interface; other site 813022274 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 813022275 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 813022276 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 813022277 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 813022278 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 813022279 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 813022280 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 813022281 active site 813022282 motif I; other site 813022283 motif II; other site 813022284 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 813022285 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 813022286 NAD binding site [chemical binding]; other site 813022287 homotetramer interface [polypeptide binding]; other site 813022288 homodimer interface [polypeptide binding]; other site 813022289 substrate binding site [chemical binding]; other site 813022290 active site 813022291 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 813022292 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813022293 RNA binding surface [nucleotide binding]; other site 813022294 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 813022295 active site 813022296 Uncharacterized conserved protein [Function unknown]; Region: COG0327 813022297 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 813022298 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 813022299 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 813022300 ring oligomerisation interface [polypeptide binding]; other site 813022301 ATP/Mg binding site [chemical binding]; other site 813022302 stacking interactions; other site 813022303 hinge regions; other site 813022304 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 813022305 oligomerisation interface [polypeptide binding]; other site 813022306 mobile loop; other site 813022307 roof hairpin; other site 813022308 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 813022309 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 813022310 active site 813022311 Zn binding site [ion binding]; other site 813022312 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 813022313 Clp amino terminal domain; Region: Clp_N; pfam02861 813022314 Clp amino terminal domain; Region: Clp_N; pfam02861 813022315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813022316 Walker A motif; other site 813022317 ATP binding site [chemical binding]; other site 813022318 Walker B motif; other site 813022319 arginine finger; other site 813022320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813022321 Walker A motif; other site 813022322 ATP binding site [chemical binding]; other site 813022323 Walker B motif; other site 813022324 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 813022325 Uncharacterized conserved protein [Function unknown]; Region: COG2912 813022326 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 813022327 IncA protein; Region: IncA; pfam04156 813022328 elongation factor P; Provisional; Region: PRK12426 813022329 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 813022330 RNA binding site [nucleotide binding]; other site 813022331 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 813022332 RNA binding site [nucleotide binding]; other site 813022333 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 813022334 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 813022335 carboxyltransferase (CT) interaction site; other site 813022336 biotinylation site [posttranslational modification]; other site 813022337 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 813022338 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 813022339 ATP-grasp domain; Region: ATP-grasp_4; cl17255 813022340 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 813022341 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 813022342 23S rRNA interface [nucleotide binding]; other site 813022343 L3 interface [polypeptide binding]; other site 813022344 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 813022345 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 813022346 NlpC/P60 family; Region: NLPC_P60; cl17555 813022347 adenylate kinase; Region: adk; TIGR01351 813022348 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 813022349 AMP-binding site [chemical binding]; other site 813022350 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 813022351 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 813022352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813022353 dimer interface [polypeptide binding]; other site 813022354 conserved gate region; other site 813022355 putative PBP binding loops; other site 813022356 ABC-ATPase subunit interface; other site 813022357 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 813022358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813022359 Walker A/P-loop; other site 813022360 ATP binding site [chemical binding]; other site 813022361 Q-loop/lid; other site 813022362 ABC transporter signature motif; other site 813022363 Walker B; other site 813022364 D-loop; other site 813022365 H-loop/switch region; other site 813022366 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 813022367 Methyltransferase domain; Region: Methyltransf_23; pfam13489 813022368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813022369 S-adenosylmethionine binding site [chemical binding]; other site 813022370 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 813022371 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 813022372 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 813022373 active site 813022374 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 813022375 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 813022376 conserved hypothetical integral membrane protein; Region: TIGR00697 813022377 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 813022378 SEC-C motif; Region: SEC-C; pfam02810 813022379 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 813022380 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813022381 active site 813022382 ATP binding site [chemical binding]; other site 813022383 substrate binding site [chemical binding]; other site 813022384 activation loop (A-loop); other site 813022385 Uncharacterized conserved protein [Function unknown]; Region: COG1262 813022386 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 813022387 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 813022388 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 813022389 nucleotide binding pocket [chemical binding]; other site 813022390 K-X-D-G motif; other site 813022391 catalytic site [active] 813022392 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 813022393 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 813022394 Helix-hairpin-helix motif; Region: HHH; pfam00633 813022395 helix-hairpin-helix signature motif; other site 813022396 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 813022397 Dimer interface [polypeptide binding]; other site 813022398 BRCT sequence motif; other site 813022399 hypothetical protein; Provisional; Region: PRK06184 813022400 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 813022401 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 813022402 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 813022403 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 813022404 FtsX-like permease family; Region: FtsX; pfam02687 813022405 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 813022406 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 813022407 Walker A/P-loop; other site 813022408 ATP binding site [chemical binding]; other site 813022409 Q-loop/lid; other site 813022410 ABC transporter signature motif; other site 813022411 Walker B; other site 813022412 D-loop; other site 813022413 H-loop/switch region; other site 813022414 membrane-attack complex / perforin; Region: MACPF; smart00457 813022415 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 813022416 PLD-like domain; Region: PLDc_2; pfam13091 813022417 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813022418 putative active site [active] 813022419 catalytic site [active] 813022420 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813022421 PLD-like domain; Region: PLDc_2; pfam13091 813022422 putative active site [active] 813022423 catalytic site [active] 813022424 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813022425 PLD-like domain; Region: PLDc_2; pfam13091 813022426 putative active site [active] 813022427 catalytic site [active] 813022428 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813022429 PLD-like domain; Region: PLDc_2; pfam13091 813022430 putative active site [active] 813022431 catalytic site [active] 813022432 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813022433 PLD-like domain; Region: PLDc_2; pfam13091 813022434 putative active site [active] 813022435 catalytic site [active] 813022436 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 813022437 PLD-like domain; Region: PLDc_2; pfam13091 813022438 putative active site [active] 813022439 catalytic site [active] 813022440 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813022441 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 813022442 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 813022443 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 813022444 trp operon repressor, proteobacterial; Region: TrpR; TIGR01321 813022445 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 813022446 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 813022447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813022448 catalytic residue [active] 813022449 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 813022450 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 813022451 substrate binding site [chemical binding]; other site 813022452 active site 813022453 catalytic residues [active] 813022454 heterodimer interface [polypeptide binding]; other site 813022455 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 813022456 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 813022457 peptide binding site [polypeptide binding]; other site 813022458 putative disulfide oxidoreductase; Provisional; Region: PRK00611 813022459 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 813022460 putative active site [active] 813022461 redox center [active] 813022462 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 813022463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813022464 Walker A/P-loop; other site 813022465 ATP binding site [chemical binding]; other site 813022466 Q-loop/lid; other site 813022467 ABC transporter signature motif; other site 813022468 Walker B; other site 813022469 D-loop; other site 813022470 H-loop/switch region; other site 813022471 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 813022472 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 813022473 Ligand binding site; other site 813022474 oligomer interface; other site 813022475 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 813022476 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 813022477 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 813022478 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 813022479 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 813022480 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 813022481 putative active site [active] 813022482 DNA polymerase III subunit delta'; Validated; Region: PRK05917 813022483 DNA polymerase III subunit delta'; Validated; Region: PRK08485 813022484 thymidylate kinase; Validated; Region: tmk; PRK00698 813022485 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 813022486 TMP-binding site; other site 813022487 ATP-binding site [chemical binding]; other site 813022488 DNA gyrase, A subunit; Region: gyrA; TIGR01063 813022489 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 813022490 CAP-like domain; other site 813022491 active site 813022492 primary dimer interface [polypeptide binding]; other site 813022493 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813022494 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813022495 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813022496 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813022497 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813022498 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 813022499 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 813022500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813022501 ATP binding site [chemical binding]; other site 813022502 Mg2+ binding site [ion binding]; other site 813022503 G-X-G motif; other site 813022504 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 813022505 anchoring element; other site 813022506 dimer interface [polypeptide binding]; other site 813022507 ATP binding site [chemical binding]; other site 813022508 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 813022509 active site 813022510 putative metal-binding site [ion binding]; other site 813022511 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 813022512 Protein of unknown function (DUF721); Region: DUF721; pfam05258 813022513 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 813022514 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 813022515 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 813022516 MgtE intracellular N domain; Region: MgtE_N; pfam03448 813022517 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 813022518 Divalent cation transporter; Region: MgtE; pfam01769 813022519 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 813022520 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 813022521 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 813022522 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 813022523 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 813022524 peptide binding site [polypeptide binding]; other site 813022525 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 813022526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813022527 dimer interface [polypeptide binding]; other site 813022528 conserved gate region; other site 813022529 putative PBP binding loops; other site 813022530 ABC-ATPase subunit interface; other site 813022531 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 813022532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813022533 dimer interface [polypeptide binding]; other site 813022534 conserved gate region; other site 813022535 putative PBP binding loops; other site 813022536 ABC-ATPase subunit interface; other site 813022537 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813022538 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 813022539 Walker A/P-loop; other site 813022540 ATP binding site [chemical binding]; other site 813022541 Q-loop/lid; other site 813022542 ABC transporter signature motif; other site 813022543 Walker B; other site 813022544 D-loop; other site 813022545 H-loop/switch region; other site 813022546 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 813022547 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 813022548 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813022549 Walker A/P-loop; other site 813022550 ATP binding site [chemical binding]; other site 813022551 Q-loop/lid; other site 813022552 ABC transporter signature motif; other site 813022553 Walker B; other site 813022554 D-loop; other site 813022555 H-loop/switch region; other site 813022556 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813022557 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 813022558 active site 813022559 ADP/pyrophosphate binding site [chemical binding]; other site 813022560 dimerization interface [polypeptide binding]; other site 813022561 allosteric effector site; other site 813022562 fructose-1,6-bisphosphate binding site; other site 813022563 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 813022564 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 813022565 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 813022566 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 813022567 active site 813022568 ADP/pyrophosphate binding site [chemical binding]; other site 813022569 dimerization interface [polypeptide binding]; other site 813022570 allosteric effector site; other site 813022571 fructose-1,6-bisphosphate binding site; other site 813022572 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 813022573 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 813022574 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 813022575 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 813022576 HIGH motif; other site 813022577 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 813022578 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 813022579 active site 813022580 KMSKS motif; other site 813022581 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 813022582 tRNA binding surface [nucleotide binding]; other site 813022583 Putative transcriptional regulator [Transcription]; Region: COG1678 813022584 Uncharacterized conserved protein [Function unknown]; Region: COG1259 813022585 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 813022586 tetramer (dimer of dimers) interface [polypeptide binding]; other site 813022587 active site 813022588 dimer interface [polypeptide binding]; other site 813022589 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 813022590 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 813022591 putative active site; other site 813022592 catalytic residue [active] 813022593 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 813022594 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 813022595 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 813022596 Ligand Binding Site [chemical binding]; other site 813022597 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 813022598 prenyltransferase; Reviewed; Region: ubiA; PRK12876 813022599 UbiA prenyltransferase family; Region: UbiA; pfam01040 813022600 aromatic acid decarboxylase; Validated; Region: PRK05920 813022601 Flavoprotein; Region: Flavoprotein; pfam02441 813022602 Uncharacterized conserved protein [Function unknown]; Region: COG1284 813022603 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 813022604 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813022605 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 813022606 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 813022607 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 813022608 Na2 binding site [ion binding]; other site 813022609 putative substrate binding site 1 [chemical binding]; other site 813022610 Na binding site 1 [ion binding]; other site 813022611 putative substrate binding site 2 [chemical binding]; other site 813022612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813022613 putative substrate translocation pore; other site 813022614 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 813022615 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 813022616 ligand binding site [chemical binding]; other site 813022617 flexible hinge region; other site 813022618 acyl carrier protein; Provisional; Region: acpP; PRK00982 813022619 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 813022620 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 813022621 NAD(P) binding site [chemical binding]; other site 813022622 homotetramer interface [polypeptide binding]; other site 813022623 homodimer interface [polypeptide binding]; other site 813022624 active site 813022625 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 813022626 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 813022627 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 813022628 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 813022629 dimer interface [polypeptide binding]; other site 813022630 active site 813022631 CoA binding pocket [chemical binding]; other site 813022632 recombination protein RecR; Region: recR; TIGR00615 813022633 RecR protein; Region: RecR; pfam02132 813022634 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 813022635 putative active site [active] 813022636 putative metal-binding site [ion binding]; other site 813022637 tetramer interface [polypeptide binding]; other site 813022638 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 813022639 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813022640 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813022641 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813022642 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 813022643 Surface antigen; Region: Bac_surface_Ag; pfam01103 813022644 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 813022645 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 813022646 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 813022647 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 813022648 trimer interface [polypeptide binding]; other site 813022649 active site 813022650 UDP-GlcNAc binding site [chemical binding]; other site 813022651 lipid binding site [chemical binding]; lipid-binding site 813022652 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 813022653 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 813022654 tetramer interface [polypeptide binding]; other site 813022655 TPP-binding site [chemical binding]; other site 813022656 heterodimer interface [polypeptide binding]; other site 813022657 phosphorylation loop region [posttranslational modification] 813022658 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 813022659 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 813022660 alpha subunit interface [polypeptide binding]; other site 813022661 TPP binding site [chemical binding]; other site 813022662 heterodimer interface [polypeptide binding]; other site 813022663 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813022664 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 813022665 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813022666 E3 interaction surface; other site 813022667 lipoyl attachment site [posttranslational modification]; other site 813022668 e3 binding domain; Region: E3_binding; pfam02817 813022669 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813022670 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 813022671 homodimer interface [polypeptide binding]; other site 813022672 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 813022673 active site pocket [active] 813022674 chromosomal replication initiation protein; Provisional; Region: PRK12422 813022675 DnaA N-terminal domain; Region: DnaA_N; pfam11638 813022676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813022677 Walker A motif; other site 813022678 ATP binding site [chemical binding]; other site 813022679 Walker B motif; other site 813022680 arginine finger; other site 813022681 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 813022682 DnaA box-binding interface [nucleotide binding]; other site 813022683 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 813022684 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 813022685 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 813022686 CAAX protease self-immunity; Region: Abi; pfam02517 813022687 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 813022688 homodimer interface [polypeptide binding]; other site 813022689 metal binding site [ion binding]; metal-binding site 813022690 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 813022691 Domain of unknown function DUF21; Region: DUF21; pfam01595 813022692 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813022693 Transporter associated domain; Region: CorC_HlyC; smart01091 813022694 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 813022695 Domain of unknown function DUF21; Region: DUF21; pfam01595 813022696 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813022697 Transporter associated domain; Region: CorC_HlyC; smart01091 813022698 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 813022699 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 813022700 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813022701 catalytic residue [active] 813022702 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 813022703 Protein phosphatase 2C; Region: PP2C; pfam00481 813022704 active site 813022705 Uncharacterized conserved protein [Function unknown]; Region: COG5465 813022706 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 813022707 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 813022708 active site 813022709 catalytic site [active] 813022710 substrate binding site [chemical binding]; other site 813022711 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 813022712 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 813022713 nucleosidase; Provisional; Region: PRK05634 813022714 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 813022715 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 813022716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813022717 Walker A/P-loop; other site 813022718 ATP binding site [chemical binding]; other site 813022719 Q-loop/lid; other site 813022720 ABC transporter signature motif; other site 813022721 Walker B; other site 813022722 D-loop; other site 813022723 H-loop/switch region; other site 813022724 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 813022725 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 813022726 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 813022727 IHF - DNA interface [nucleotide binding]; other site 813022728 IHF dimer interface [polypeptide binding]; other site 813022729 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 813022730 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 813022731 active site 813022732 metal binding site [ion binding]; metal-binding site 813022733 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 813022734 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 813022735 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813022736 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813022737 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 813022738 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 813022739 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 813022740 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 813022741 MraW methylase family; Region: Methyltransf_5; pfam01795 813022742 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813022743 TPR motif; other site 813022744 binding surface 813022745 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 813022746 DnaA N-terminal domain; Region: DnaA_N; pfam11638 813022747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813022748 Walker A motif; other site 813022749 ATP binding site [chemical binding]; other site 813022750 Walker B motif; other site 813022751 arginine finger; other site 813022752 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 813022753 DnaA box-binding interface [nucleotide binding]; other site 813022754 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 813022755 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 813022756 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 813022757 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 813022758 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 813022759 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 813022760 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 813022761 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 813022762 lipoyl attachment site [posttranslational modification]; other site 813022763 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 813022764 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 813022765 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813022766 putative active site [active] 813022767 catalytic site [active] 813022768 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 813022769 putative active site [active] 813022770 catalytic site [active] 813022771 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 813022772 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 813022773 Clp amino terminal domain; Region: Clp_N; pfam02861 813022774 Clp amino terminal domain; Region: Clp_N; pfam02861 813022775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813022776 Walker A motif; other site 813022777 ATP binding site [chemical binding]; other site 813022778 Walker B motif; other site 813022779 arginine finger; other site 813022780 UvrB/uvrC motif; Region: UVR; pfam02151 813022781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813022782 Walker A motif; other site 813022783 ATP binding site [chemical binding]; other site 813022784 Walker B motif; other site 813022785 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 813022786 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 813022787 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 813022788 Ligand Binding Site [chemical binding]; other site 813022789 Helix-turn-helix domain; Region: HTH_17; pfam12728 813022790 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 813022791 active site 813022792 phosphorylation site [posttranslational modification] 813022793 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 813022794 active site 813022795 phosphorylation site [posttranslational modification] 813022796 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 813022797 trimer interface [polypeptide binding]; other site 813022798 active site 813022799 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 813022800 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 813022801 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 813022802 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 813022803 active site 813022804 substrate binding site [chemical binding]; other site 813022805 metal binding site [ion binding]; metal-binding site 813022806 ribonuclease III; Reviewed; Region: rnc; PRK00102 813022807 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 813022808 dimerization interface [polypeptide binding]; other site 813022809 active site 813022810 metal binding site [ion binding]; metal-binding site 813022811 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 813022812 dsRNA binding site [nucleotide binding]; other site 813022813 DNA repair protein RadA; Provisional; Region: PRK11823 813022814 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 813022815 Walker A motif/ATP binding site; other site 813022816 ATP binding site [chemical binding]; other site 813022817 Walker B motif; other site 813022818 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 813022819 porphobilinogen deaminase; Provisional; Region: PRK01066 813022820 Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379 813022821 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 813022822 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813022823 active site 813022824 ATP binding site [chemical binding]; other site 813022825 substrate binding site [chemical binding]; other site 813022826 activation loop (A-loop); other site 813022827 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 813022828 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 813022829 HIGH motif; other site 813022830 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 813022831 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 813022832 active site 813022833 KMSKS motif; other site 813022834 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 813022835 tRNA binding surface [nucleotide binding]; other site 813022836 anticodon binding site; other site 813022837 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 813022838 V-type ATP synthase subunit K; Provisional; Region: PRK09621 813022839 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 813022840 V-type ATP synthase subunit I; Validated; Region: PRK05771 813022841 Protein of unknown function (DUF1319); Region: DUF1319; pfam07028 813022842 V-type ATP synthase subunit D; Provisional; Region: PRK02195 813022843 V-type ATP synthase subunit B; Provisional; Region: PRK02118 813022844 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813022845 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 813022846 Walker A motif homologous position; other site 813022847 Walker B motif; other site 813022848 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 813022849 V-type ATP synthase subunit E; Provisional; Region: PRK01005 813022850 V-type ATP synthase subunit E; Provisional; Region: PRK01558 813022851 transaldolase-like protein; Provisional; Region: PTZ00411 813022852 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 813022853 active site 813022854 dimer interface [polypeptide binding]; other site 813022855 catalytic residue [active] 813022856 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 813022857 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 813022858 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 813022859 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 813022860 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 813022861 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 813022862 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 813022863 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 813022864 DNA binding site [nucleotide binding] 813022865 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 813022866 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 813022867 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 813022868 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 813022869 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 813022870 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 813022871 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 813022872 RPB12 interaction site [polypeptide binding]; other site 813022873 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 813022874 RPB3 interaction site [polypeptide binding]; other site 813022875 RPB1 interaction site [polypeptide binding]; other site 813022876 RPB11 interaction site [polypeptide binding]; other site 813022877 RPB10 interaction site [polypeptide binding]; other site 813022878 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 813022879 L11 interface [polypeptide binding]; other site 813022880 putative EF-Tu interaction site [polypeptide binding]; other site 813022881 putative EF-G interaction site [polypeptide binding]; other site 813022882 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 813022883 23S rRNA interface [nucleotide binding]; other site 813022884 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 813022885 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 813022886 mRNA/rRNA interface [nucleotide binding]; other site 813022887 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 813022888 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 813022889 putative thiostrepton binding site; other site 813022890 23S rRNA interface [nucleotide binding]; other site 813022891 L7/L12 interface [polypeptide binding]; other site 813022892 L25 interface [polypeptide binding]; other site 813022893 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 813022894 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 813022895 putative homodimer interface [polypeptide binding]; other site 813022896 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 813022897 heterodimer interface [polypeptide binding]; other site 813022898 homodimer interface [polypeptide binding]; other site 813022899 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 813022900 elongation factor Tu; Reviewed; Region: PRK12735 813022901 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 813022902 G1 box; other site 813022903 GEF interaction site [polypeptide binding]; other site 813022904 GTP/Mg2+ binding site [chemical binding]; other site 813022905 Switch I region; other site 813022906 G2 box; other site 813022907 G3 box; other site 813022908 Switch II region; other site 813022909 G4 box; other site 813022910 G5 box; other site 813022911 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 813022912 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 813022913 Antibiotic Binding Site [chemical binding]; other site 813022914 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 813022915 rRNA binding site [nucleotide binding]; other site 813022916 predicted 30S ribosome binding site; other site 813022917 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 813022918 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 813022919 active site 813022920 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 813022921 triosephosphate isomerase; Provisional; Region: PRK14565 813022922 substrate binding site [chemical binding]; other site 813022923 dimer interface [polypeptide binding]; other site 813022924 catalytic triad [active] 813022925 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 813022926 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 813022927 generic binding surface II; other site 813022928 generic binding surface I; other site 813022929 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 813022930 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 813022931 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 813022932 TPP-binding site [chemical binding]; other site 813022933 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 813022934 PYR/PP interface [polypeptide binding]; other site 813022935 dimer interface [polypeptide binding]; other site 813022936 TPP binding site [chemical binding]; other site 813022937 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813022938 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 813022939 pyruvate kinase; Region: pyruv_kin; TIGR01064 813022940 domain interfaces; other site 813022941 active site 813022942 excinuclease ABC subunit A; Provisional; Region: PRK00635 813022943 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 813022944 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 813022945 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 813022946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813022947 Walker A/P-loop; other site 813022948 ATP binding site [chemical binding]; other site 813022949 Q-loop/lid; other site 813022950 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813022951 ABC transporter signature motif; other site 813022952 Walker B; other site 813022953 D-loop; other site 813022954 H-loop/switch region; other site 813022955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813022956 Walker A/P-loop; other site 813022957 ATP binding site [chemical binding]; other site 813022958 Q-loop/lid; other site 813022959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813022960 Q-loop/lid; other site 813022961 ABC transporter signature motif; other site 813022962 Walker B; other site 813022963 D-loop; other site 813022964 H-loop/switch region; other site 813022965 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 813022966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813022967 Walker A motif; other site 813022968 ATP binding site [chemical binding]; other site 813022969 Walker B motif; other site 813022970 arginine finger; other site 813022971 hypothetical protein; Validated; Region: PRK00153 813022972 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 813022973 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 813022974 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 813022975 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 813022976 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 813022977 dimerization domain swap beta strand [polypeptide binding]; other site 813022978 regulatory protein interface [polypeptide binding]; other site 813022979 active site 813022980 regulatory phosphorylation site [posttranslational modification]; other site 813022981 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 813022982 Competence protein; Region: Competence; pfam03772 813022983 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 813022984 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 813022985 tetramer interface [polypeptide binding]; other site 813022986 TPP-binding site [chemical binding]; other site 813022987 heterodimer interface [polypeptide binding]; other site 813022988 phosphorylation loop region [posttranslational modification] 813022989 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 813022990 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 813022991 alpha subunit interface [polypeptide binding]; other site 813022992 TPP binding site [chemical binding]; other site 813022993 heterodimer interface [polypeptide binding]; other site 813022994 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813022995 chaperone protein DnaJ; Provisional; Region: PRK14284 813022996 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 813022997 HSP70 interaction site [polypeptide binding]; other site 813022998 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 813022999 Zn binding sites [ion binding]; other site 813023000 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 813023001 dimer interface [polypeptide binding]; other site 813023002 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 813023003 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 813023004 Glycoprotease family; Region: Peptidase_M22; pfam00814 813023005 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 813023006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813023007 Walker A motif; other site 813023008 ATP binding site [chemical binding]; other site 813023009 Walker B motif; other site 813023010 arginine finger; other site 813023011 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 813023012 ribonuclease Z; Region: RNase_Z; TIGR02651 813023013 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 813023014 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 813023015 active site 813023016 Int/Topo IB signature motif; other site 813023017 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 813023018 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813023019 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813023020 ABC transporter; Region: ABC_tran_2; pfam12848 813023021 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 813023022 Maf-like protein; Region: Maf; pfam02545 813023023 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 813023024 active site 813023025 dimer interface [polypeptide binding]; other site 813023026 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 813023027 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 813023028 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 813023029 dimethyladenosine transferase; Region: ksgA; TIGR00755 813023030 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 813023031 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 813023032 catalytic residues [active] 813023033 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 813023034 dihydrodipicolinate synthase; Region: dapA; TIGR00674 813023035 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 813023036 inhibitor site; inhibition site 813023037 active site 813023038 dimer interface [polypeptide binding]; other site 813023039 catalytic residue [active] 813023040 aspartate kinase; Provisional; Region: PRK05925 813023041 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 813023042 putative catalytic residues [active] 813023043 nucleotide binding site [chemical binding]; other site 813023044 aspartate binding site [chemical binding]; other site 813023045 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 813023046 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 813023047 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 813023048 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 813023049 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 813023050 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 813023051 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 813023052 hinge; other site 813023053 active site 813023054 shikimate kinase; Provisional; Region: PRK00625 813023055 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 813023056 ADP binding site [chemical binding]; other site 813023057 magnesium binding site [ion binding]; other site 813023058 putative shikimate binding site; other site 813023059 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 813023060 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 813023061 Tetramer interface [polypeptide binding]; other site 813023062 active site 813023063 FMN-binding site [chemical binding]; other site 813023064 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 813023065 active site 813023066 dimer interface [polypeptide binding]; other site 813023067 metal binding site [ion binding]; metal-binding site 813023068 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 813023069 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 813023070 active site 813023071 catalytic residue [active] 813023072 dimer interface [polypeptide binding]; other site 813023073 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 813023074 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 813023075 shikimate binding site; other site 813023076 NAD(P) binding site [chemical binding]; other site 813023077 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 813023078 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 813023079 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 813023080 malate dehydrogenase; Provisional; Region: PRK05442 813023081 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 813023082 NAD(P) binding site [chemical binding]; other site 813023083 dimer interface [polypeptide binding]; other site 813023084 malate binding site [chemical binding]; other site 813023085 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 813023086 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 813023087 active site 813023088 dimer interface [polypeptide binding]; other site 813023089 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 813023090 dimer interface [polypeptide binding]; other site 813023091 active site 813023092 GTPases [General function prediction only]; Region: HflX; COG2262 813023093 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 813023094 HflX GTPase family; Region: HflX; cd01878 813023095 G1 box; other site 813023096 GTP/Mg2+ binding site [chemical binding]; other site 813023097 Switch I region; other site 813023098 G2 box; other site 813023099 G3 box; other site 813023100 Switch II region; other site 813023101 G4 box; other site 813023102 G5 box; other site 813023103 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 813023104 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 813023105 substrate binding pocket [chemical binding]; other site 813023106 membrane-bound complex binding site; other site 813023107 hinge residues; other site 813023108 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 813023109 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 813023110 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 813023111 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 813023112 nucleotide binding site/active site [active] 813023113 Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286 813023114 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 813023115 hypothetical protein; Validated; Region: PRK00647 813023116 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 813023117 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 813023118 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 813023119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813023120 homodimer interface [polypeptide binding]; other site 813023121 catalytic residue [active] 813023122 ABC transporter substrate binding protein; Region: ABC_sub_bind; pfam04392 813023123 prolyl-tRNA synthetase; Provisional; Region: PRK09194 813023124 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 813023125 dimer interface [polypeptide binding]; other site 813023126 motif 1; other site 813023127 active site 813023128 motif 2; other site 813023129 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 813023130 putative deacylase active site [active] 813023131 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813023132 active site 813023133 motif 3; other site 813023134 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 813023135 anticodon binding site; other site 813023136 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 813023137 GrpE; Region: GrpE; pfam01025 813023138 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 813023139 dimer interface [polypeptide binding]; other site 813023140 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 813023141 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 813023142 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 813023143 nucleotide binding site [chemical binding]; other site 813023144 NEF interaction site [polypeptide binding]; other site 813023145 SBD interface [polypeptide binding]; other site 813023146 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 813023147 Exoribonuclease R [Transcription]; Region: VacB; COG0557 813023148 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 813023149 RNB domain; Region: RNB; pfam00773 813023150 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 813023151 Putative zinc ribbon domain; Region: DUF164; pfam02591 813023152 KpsF/GutQ family protein; Region: kpsF; TIGR00393 813023153 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 813023154 putative active site [active] 813023155 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 813023156 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 813023157 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 813023158 E3 interaction surface; other site 813023159 lipoyl attachment site [posttranslational modification]; other site 813023160 e3 binding domain; Region: E3_binding; pfam02817 813023161 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 813023162 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 813023163 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 813023164 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 813023165 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 813023166 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 813023167 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 813023168 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 813023169 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 813023170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813023171 S-adenosylmethionine binding site [chemical binding]; other site 813023172 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 813023173 Lumazine binding domain; Region: Lum_binding; pfam00677 813023174 Lumazine binding domain; Region: Lum_binding; pfam00677 813023175 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 813023176 ATP cone domain; Region: ATP-cone; pfam03477 813023177 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 813023178 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 813023179 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 813023180 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 813023181 Predicted membrane protein [Function unknown]; Region: COG3952 813023182 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 813023183 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813023184 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813023185 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813023186 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813023187 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813023188 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813023189 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813023190 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813023191 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 813023192 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 813023193 intersubunit interface [polypeptide binding]; other site 813023194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 813023195 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 813023196 Walker A/P-loop; other site 813023197 ATP binding site [chemical binding]; other site 813023198 Q-loop/lid; other site 813023199 ABC transporter signature motif; other site 813023200 Walker B; other site 813023201 D-loop; other site 813023202 H-loop/switch region; other site 813023203 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 813023204 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 813023205 ABC-ATPase subunit interface; other site 813023206 dimer interface [polypeptide binding]; other site 813023207 putative PBP binding regions; other site 813023208 GTPase CgtA; Reviewed; Region: obgE; PRK12299 813023209 GTP1/OBG; Region: GTP1_OBG; pfam01018 813023210 Obg GTPase; Region: Obg; cd01898 813023211 G1 box; other site 813023212 GTP/Mg2+ binding site [chemical binding]; other site 813023213 Switch I region; other site 813023214 G2 box; other site 813023215 G3 box; other site 813023216 Switch II region; other site 813023217 G4 box; other site 813023218 G5 box; other site 813023219 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 813023220 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 813023221 Uncharacterized conserved protein [Function unknown]; Region: COG2928 813023222 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 813023223 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 813023224 FOG: CBS domain [General function prediction only]; Region: COG0517 813023225 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 813023226 Transporter associated domain; Region: CorC_HlyC; smart01091 813023227 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 813023228 anti sigma factor interaction site; other site 813023229 regulatory phosphorylation site [posttranslational modification]; other site 813023230 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 813023231 hypothetical protein; Provisional; Region: PRK05926 813023232 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813023233 FeS/SAM binding site; other site 813023234 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 813023235 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 813023236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813023237 S-adenosylmethionine binding site [chemical binding]; other site 813023238 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 813023239 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 813023240 diaminopimelate epimerase; Region: DapF; TIGR00652 813023241 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 813023242 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 813023243 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 813023244 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 813023245 oligomer interface [polypeptide binding]; other site 813023246 active site residues [active] 813023247 serine hydroxymethyltransferase; Provisional; Region: PRK13580 813023248 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 813023249 dimer interface [polypeptide binding]; other site 813023250 active site 813023251 glycine-pyridoxal phosphate binding site [chemical binding]; other site 813023252 folate binding site [chemical binding]; other site 813023253 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 813023254 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 813023255 active site 813023256 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 813023257 homotrimer interaction site [polypeptide binding]; other site 813023258 zinc binding site [ion binding]; other site 813023259 CDP-binding sites; other site 813023260 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 813023261 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 813023262 FAD binding pocket [chemical binding]; other site 813023263 conserved FAD binding motif [chemical binding]; other site 813023264 phosphate binding motif [ion binding]; other site 813023265 beta-alpha-beta structure motif; other site 813023266 NAD binding pocket [chemical binding]; other site 813023267 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 813023268 elongation factor G; Reviewed; Region: PRK12739 813023269 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 813023270 G1 box; other site 813023271 putative GEF interaction site [polypeptide binding]; other site 813023272 GTP/Mg2+ binding site [chemical binding]; other site 813023273 Switch I region; other site 813023274 G2 box; other site 813023275 G3 box; other site 813023276 Switch II region; other site 813023277 G4 box; other site 813023278 G5 box; other site 813023279 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 813023280 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 813023281 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 813023282 30S ribosomal protein S7; Validated; Region: PRK05302 813023283 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 813023284 S17 interaction site [polypeptide binding]; other site 813023285 S8 interaction site; other site 813023286 16S rRNA interaction site [nucleotide binding]; other site 813023287 streptomycin interaction site [chemical binding]; other site 813023288 23S rRNA interaction site [nucleotide binding]; other site 813023289 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 813023290 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 813023291 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 813023292 protein binding site [polypeptide binding]; other site 813023293 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 813023294 Catalytic dyad [active] 813023295 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 813023296 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 813023297 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 813023298 Domain of unknown function DUF11; Region: DUF11; pfam01345 813023299 Domain of unknown function DUF11; Region: DUF11; pfam01345 813023300 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 813023301 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 813023302 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 813023303 HIGH motif; other site 813023304 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 813023305 active site 813023306 KMSKS motif; other site 813023307 Helix-turn-helix domain; Region: HTH_17; pfam12728 813023308 Helix-turn-helix domain; Region: HTH_17; cl17695 813023309 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 813023310 DHH family; Region: DHH; pfam01368 813023311 DHHA1 domain; Region: DHHA1; pfam02272 813023312 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 813023313 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 813023314 Protein export membrane protein; Region: SecD_SecF; pfam02355 813023315 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 813023316 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 813023317 catalytic residue [active] 813023318 putative FPP diphosphate binding site; other site 813023319 putative FPP binding hydrophobic cleft; other site 813023320 dimer interface [polypeptide binding]; other site 813023321 putative IPP diphosphate binding site; other site 813023322 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 813023323 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 813023324 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 813023325 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 813023326 putative acyl-acceptor binding pocket; other site 813023327 arginine-tRNA ligase; Region: PLN02286 813023328 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 813023329 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 813023330 active site 813023331 HIGH motif; other site 813023332 KMSK motif region; other site 813023333 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813023334 tRNA binding surface [nucleotide binding]; other site 813023335 anticodon binding site; other site 813023336 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 813023337 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 813023338 hinge; other site 813023339 active site 813023340 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 813023341 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 813023342 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 813023343 Coenzyme A binding pocket [chemical binding]; other site 813023344 PCRF domain; Region: PCRF; pfam03462 813023345 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 813023346 RF-1 domain; Region: RF-1; pfam00472 813023347 SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531 813023348 SWI complex, BAF60b domains; Region: SWIB; smart00151 813023349 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 813023350 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813023351 putative active site [active] 813023352 putative metal binding site [ion binding]; other site 813023353 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 813023354 substrate binding site; other site 813023355 dimer interface; other site 813023356 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 813023357 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 813023358 dimerization interface 3.5A [polypeptide binding]; other site 813023359 active site 813023360 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 813023361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 813023362 active site 813023363 motif I; other site 813023364 motif II; other site 813023365 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 813023366 PAS domain; Region: PAS; smart00091 813023367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 813023368 dimer interface [polypeptide binding]; other site 813023369 phosphorylation site [posttranslational modification] 813023370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813023371 ATP binding site [chemical binding]; other site 813023372 Mg2+ binding site [ion binding]; other site 813023373 G-X-G motif; other site 813023374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 813023375 Response regulator receiver domain; Region: Response_reg; pfam00072 813023376 active site 813023377 phosphorylation site [posttranslational modification] 813023378 intermolecular recognition site; other site 813023379 dimerization interface [polypeptide binding]; other site 813023380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813023381 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 813023382 Walker A motif; other site 813023383 ATP binding site [chemical binding]; other site 813023384 Walker B motif; other site 813023385 arginine finger; other site 813023386 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 813023387 Uncharacterized conserved protein [Function unknown]; Region: COG1723 813023388 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 813023389 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 813023390 putative tRNA-binding site [nucleotide binding]; other site 813023391 B3/4 domain; Region: B3_4; pfam03483 813023392 tRNA synthetase B5 domain; Region: B5; pfam03484 813023393 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 813023394 dimer interface [polypeptide binding]; other site 813023395 motif 1; other site 813023396 motif 3; other site 813023397 motif 2; other site 813023398 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 813023399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813023400 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 813023401 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 813023402 DNA binding site [nucleotide binding] 813023403 active site 813023404 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 813023405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813023406 dimer interface [polypeptide binding]; other site 813023407 conserved gate region; other site 813023408 putative PBP binding loops; other site 813023409 ABC-ATPase subunit interface; other site 813023410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 813023411 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 813023412 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 813023413 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 813023414 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 813023415 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 813023416 putative active site [active] 813023417 putative metal binding site [ion binding]; other site 813023418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813023419 binding surface 813023420 TPR motif; other site 813023421 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 813023422 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 813023423 C-terminal domain interface [polypeptide binding]; other site 813023424 active site 813023425 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 813023426 active site 813023427 N-terminal domain interface [polypeptide binding]; other site 813023428 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 813023429 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 813023430 substrate binding pocket [chemical binding]; other site 813023431 membrane-bound complex binding site; other site 813023432 hinge residues; other site 813023433 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 813023434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813023435 S-adenosylmethionine binding site [chemical binding]; other site 813023436 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 813023437 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813023438 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 813023439 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 813023440 ligand binding site; other site 813023441 oligomer interface; other site 813023442 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 813023443 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 813023444 N-terminal domain interface [polypeptide binding]; other site 813023445 sulfate 1 binding site; other site 813023446 transcription termination factor Rho; Region: rho; TIGR00767 813023447 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 813023448 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 813023449 RNA binding site [nucleotide binding]; other site 813023450 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 813023451 multimer interface [polypeptide binding]; other site 813023452 Walker A motif; other site 813023453 ATP binding site [chemical binding]; other site 813023454 Walker B motif; other site 813023455 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 813023456 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 813023457 CoA-binding site [chemical binding]; other site 813023458 ATP-binding [chemical binding]; other site 813023459 DNA polymerase I; Provisional; Region: PRK05755 813023460 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 813023461 active site 813023462 metal binding site 1 [ion binding]; metal-binding site 813023463 putative 5' ssDNA interaction site; other site 813023464 metal binding site 3; metal-binding site 813023465 metal binding site 2 [ion binding]; metal-binding site 813023466 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 813023467 putative DNA binding site [nucleotide binding]; other site 813023468 putative metal binding site [ion binding]; other site 813023469 3'-5' exonuclease; Region: 35EXOc; smart00474 813023470 active site 813023471 substrate binding site [chemical binding]; other site 813023472 catalytic site [active] 813023473 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 813023474 active site 813023475 DNA binding site [nucleotide binding] 813023476 catalytic site [active] 813023477 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 813023478 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 813023479 tandem repeat interface [polypeptide binding]; other site 813023480 oligomer interface [polypeptide binding]; other site 813023481 active site residues [active] 813023482 TLC ATP/ADP transporter; Region: TLC; pfam03219 813023483 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 813023484 replicative DNA helicase; Provisional; Region: PRK06321 813023485 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 813023486 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 813023487 Walker A motif; other site 813023488 ATP binding site [chemical binding]; other site 813023489 Walker B motif; other site 813023490 DNA binding loops [nucleotide binding] 813023491 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 813023492 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 813023493 RuvA N terminal domain; Region: RuvA_N; pfam01330 813023494 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 813023495 active site 813023496 putative DNA-binding cleft [nucleotide binding]; other site 813023497 dimer interface [polypeptide binding]; other site 813023498 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 813023499 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 813023500 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 813023501 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 813023502 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 813023503 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 813023504 alphaNTD - beta interaction site [polypeptide binding]; other site 813023505 alphaNTD homodimer interface [polypeptide binding]; other site 813023506 alphaNTD - beta' interaction site [polypeptide binding]; other site 813023507 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 813023508 30S ribosomal protein S11; Validated; Region: PRK05309 813023509 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 813023510 30S ribosomal protein S13; Region: bact_S13; TIGR03631 813023511 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 813023512 SecY translocase; Region: SecY; pfam00344 813023513 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 813023514 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 813023515 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 813023516 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 813023517 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 813023518 5S rRNA interface [nucleotide binding]; other site 813023519 23S rRNA interface [nucleotide binding]; other site 813023520 L5 interface [polypeptide binding]; other site 813023521 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 813023522 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 813023523 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 813023524 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 813023525 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 813023526 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 813023527 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 813023528 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 813023529 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 813023530 RNA binding site [nucleotide binding]; other site 813023531 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 813023532 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 813023533 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 813023534 23S rRNA interface [nucleotide binding]; other site 813023535 putative translocon interaction site; other site 813023536 signal recognition particle (SRP54) interaction site; other site 813023537 L23 interface [polypeptide binding]; other site 813023538 trigger factor interaction site; other site 813023539 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 813023540 23S rRNA interface [nucleotide binding]; other site 813023541 5S rRNA interface [nucleotide binding]; other site 813023542 putative antibiotic binding site [chemical binding]; other site 813023543 L25 interface [polypeptide binding]; other site 813023544 L27 interface [polypeptide binding]; other site 813023545 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 813023546 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 813023547 G-X-X-G motif; other site 813023548 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 813023549 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 813023550 putative translocon binding site; other site 813023551 protein-rRNA interface [nucleotide binding]; other site 813023552 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 813023553 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 813023554 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 813023555 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 813023556 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 813023557 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 813023558 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 813023559 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 813023560 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 813023561 putative active site [active] 813023562 substrate binding site [chemical binding]; other site 813023563 putative cosubstrate binding site; other site 813023564 catalytic site [active] 813023565 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 813023566 substrate binding site [chemical binding]; other site 813023567 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 813023568 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 813023569 active site 813023570 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 813023571 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 813023572 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 813023573 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 813023574 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 813023575 putative active site [active] 813023576 catalytic triad [active] 813023577 putative dimer interface [polypeptide binding]; other site 813023578 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 813023579 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 813023580 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 813023581 active site 813023582 catalytic site [active] 813023583 substrate binding site [chemical binding]; other site 813023584 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 813023585 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 813023586 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 813023587 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 813023588 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813023589 catalytic residues [active] 813023590 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 813023591 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 813023592 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 813023593 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 813023594 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 813023595 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 813023596 dimer interface [polypeptide binding]; other site 813023597 anticodon binding site; other site 813023598 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 813023599 homodimer interface [polypeptide binding]; other site 813023600 motif 1; other site 813023601 active site 813023602 motif 2; other site 813023603 GAD domain; Region: GAD; pfam02938 813023604 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813023605 active site 813023606 motif 3; other site 813023607 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 813023608 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 813023609 dimer interface [polypeptide binding]; other site 813023610 motif 1; other site 813023611 active site 813023612 motif 2; other site 813023613 motif 3; other site 813023614 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 813023615 anticodon binding site; other site 813023616 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 813023617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813023618 putative substrate translocation pore; other site 813023619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813023620 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 813023621 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 813023622 active site 813023623 PHP Thumb interface [polypeptide binding]; other site 813023624 metal binding site [ion binding]; metal-binding site 813023625 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 813023626 generic binding surface I; other site 813023627 generic binding surface II; other site 813023628 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 813023629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 813023630 Mg2+ binding site [ion binding]; other site 813023631 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 813023632 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 813023633 branched-chain amino acid uptake carrier; Region: livcs; TIGR00796 813023634 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 813023635 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813023636 ATP binding site [chemical binding]; other site 813023637 putative Mg++ binding site [ion binding]; other site 813023638 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813023639 nucleotide binding region [chemical binding]; other site 813023640 ATP-binding site [chemical binding]; other site 813023641 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 813023642 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 813023643 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 813023644 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 813023645 lipoate synthase; Region: lipA; TIGR00510 813023646 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 813023647 FeS/SAM binding site; other site 813023648 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 813023649 type III secretion system protein; Validated; Region: PRK06328 813023650 Flagellar assembly protein FliH; Region: FliH; pfam02108 813023651 type III secretion system protein; Reviewed; Region: PRK09617 813023652 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 813023653 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 813023654 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 813023655 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 813023656 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 813023657 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 813023658 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 813023659 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 813023660 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 813023661 Walker A motif; other site 813023662 ATP binding site [chemical binding]; other site 813023663 Walker B motif; other site 813023664 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 813023665 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813023666 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 813023667 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 813023668 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 813023669 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 813023670 active site 813023671 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 813023672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 813023673 ATP binding site [chemical binding]; other site 813023674 Mg2+ binding site [ion binding]; other site 813023675 G-X-G motif; other site 813023676 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 813023677 ATP binding site [chemical binding]; other site 813023678 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 813023679 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 813023680 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813023681 binding surface 813023682 TPR motif; other site 813023683 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 813023684 EamA-like transporter family; Region: EamA; pfam00892 813023685 EamA-like transporter family; Region: EamA; pfam00892 813023686 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 813023687 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cd01616 813023688 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 813023689 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 813023690 active site 813023691 dimer interface [polypeptide binding]; other site 813023692 motif 1; other site 813023693 motif 2; other site 813023694 motif 3; other site 813023695 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 813023696 anticodon binding site; other site 813023697 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 813023698 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 813023699 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 813023700 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 813023701 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 813023702 active site 813023703 HIGH motif; other site 813023704 dimer interface [polypeptide binding]; other site 813023705 KMSKS motif; other site 813023706 excinuclease ABC subunit B; Provisional; Region: PRK05298 813023707 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813023708 ATP binding site [chemical binding]; other site 813023709 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813023710 nucleotide binding region [chemical binding]; other site 813023711 ATP-binding site [chemical binding]; other site 813023712 Ultra-violet resistance protein B; Region: UvrB; pfam12344 813023713 UvrB/uvrC motif; Region: UVR; pfam02151 813023714 enolase; Provisional; Region: eno; PRK00077 813023715 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 813023716 dimer interface [polypeptide binding]; other site 813023717 metal binding site [ion binding]; metal-binding site 813023718 substrate binding pocket [chemical binding]; other site 813023719 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 813023720 HAMP domain; Region: HAMP; pfam00672 813023721 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 813023722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 813023723 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 813023724 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 813023725 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 813023726 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 813023727 L-aspartate oxidase; Provisional; Region: PRK06175 813023728 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 813023729 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 813023730 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 813023731 active site 813023732 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 813023733 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 813023734 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 813023735 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 813023736 DsbD alpha interface [polypeptide binding]; other site 813023737 catalytic residues [active] 813023738 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 813023739 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 813023740 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 813023741 translocation protein TolB; Provisional; Region: tolB; PRK01029 813023742 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813023743 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813023744 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 813023745 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 813023746 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 813023747 ligand binding site [chemical binding]; other site 813023748 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 813023749 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813023750 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 813023751 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 813023752 dimer interface [polypeptide binding]; other site 813023753 decamer (pentamer of dimers) interface [polypeptide binding]; other site 813023754 catalytic triad [active] 813023755 peroxidatic and resolving cysteines [active] 813023756 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 813023757 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 813023758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 813023759 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 813023760 active site 813023761 dimerization interface [polypeptide binding]; other site 813023762 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 813023763 ligand binding site [chemical binding]; other site 813023764 active site 813023765 UGI interface [polypeptide binding]; other site 813023766 catalytic site [active] 813023767 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 813023768 Part of AAA domain; Region: AAA_19; pfam13245 813023769 Family description; Region: UvrD_C_2; pfam13538 813023770 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 813023771 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 813023772 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 813023773 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 813023774 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 813023775 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 813023776 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 813023777 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 813023778 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 813023779 folate binding site [chemical binding]; other site 813023780 NADP+ binding site [chemical binding]; other site 813023781 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 813023782 catalytic center binding site [active] 813023783 ATP binding site [chemical binding]; other site 813023784 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 813023785 dihydropteroate synthase; Region: DHPS; TIGR01496 813023786 substrate binding pocket [chemical binding]; other site 813023787 dimer interface [polypeptide binding]; other site 813023788 inhibitor binding site; inhibition site 813023789 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 813023790 homooctamer interface [polypeptide binding]; other site 813023791 active site 813023792 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 813023793 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 813023794 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 813023795 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 813023796 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 813023797 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 813023798 DNA binding residues [nucleotide binding] 813023799 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 813023800 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 813023801 Effector from type III secretion system; Region: Effector_1; pfam04518 813023802 Effector from type III secretion system; Region: Effector_1; pfam04518 813023803 Effector from type III secretion system; Region: Effector_1; pfam04518 813023804 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 813023805 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 813023806 MviN-like protein; Region: MVIN; pfam03023 813023807 endonuclease IV; Provisional; Region: PRK01060 813023808 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 813023809 AP (apurinic/apyrimidinic) site pocket; other site 813023810 DNA interaction; other site 813023811 Metal-binding active site; metal-binding site 813023812 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 813023813 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 813023814 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813023815 RNA binding surface [nucleotide binding]; other site 813023816 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 813023817 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 813023818 active site residue [active] 813023819 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 813023820 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 813023821 substrate binding pocket [chemical binding]; other site 813023822 chain length determination region; other site 813023823 substrate-Mg2+ binding site; other site 813023824 catalytic residues [active] 813023825 aspartate-rich region 1; other site 813023826 active site lid residues [active] 813023827 aspartate-rich region 2; other site 813023828 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 813023829 putative trimer interface [polypeptide binding]; other site 813023830 putative CoA binding site [chemical binding]; other site 813023831 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 813023832 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 813023833 DNA binding site [nucleotide binding] 813023834 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 813023835 Thymidylate synthase complementing protein; Region: Thy1; cl03630 813023836 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 813023837 dimer interface [polypeptide binding]; other site 813023838 active site 813023839 aspartate-rich active site metal binding site; other site 813023840 allosteric magnesium binding site [ion binding]; other site 813023841 Schiff base residues; other site 813023842 NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit; Region: nqrA; TIGR01936 813023843 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 813023844 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 813023845 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 813023846 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 813023847 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 813023848 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 813023849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 813023850 homodimer interface [polypeptide binding]; other site 813023851 catalytic residue [active] 813023852 rod shape-determining protein MreC; Provisional; Region: PRK14872 813023853 rod shape-determining protein MreC; Region: MreC; pfam04085 813023854 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 813023855 Part of AAA domain; Region: AAA_19; pfam13245 813023856 Family description; Region: UvrD_C_2; pfam13538 813023857 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 813023858 Major Facilitator Superfamily; Region: MFS_1; pfam07690 813023859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 813023860 putative substrate translocation pore; other site 813023861 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 813023862 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 813023863 active site 813023864 interdomain interaction site; other site 813023865 putative metal-binding site [ion binding]; other site 813023866 nucleotide binding site [chemical binding]; other site 813023867 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 813023868 domain I; other site 813023869 DNA binding groove [nucleotide binding] 813023870 phosphate binding site [ion binding]; other site 813023871 domain II; other site 813023872 domain III; other site 813023873 nucleotide binding site [chemical binding]; other site 813023874 catalytic site [active] 813023875 domain IV; other site 813023876 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813023877 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813023878 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 813023879 SWI complex, BAF60b domains; Region: SWIB; smart00151 813023880 Predicted integral membrane protein [Function unknown]; Region: COG0762 813023881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813023882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 813023883 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 813023884 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 813023885 recombinase A; Provisional; Region: recA; PRK09354 813023886 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 813023887 hexamer interface [polypeptide binding]; other site 813023888 Walker A motif; other site 813023889 ATP binding site [chemical binding]; other site 813023890 Walker B motif; other site 813023891 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 813023892 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 813023893 AAA domain; Region: AAA_30; pfam13604 813023894 Family description; Region: UvrD_C_2; pfam13538 813023895 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 813023896 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 813023897 Walker A/P-loop; other site 813023898 ATP binding site [chemical binding]; other site 813023899 Q-loop/lid; other site 813023900 ABC transporter signature motif; other site 813023901 Walker B; other site 813023902 D-loop; other site 813023903 H-loop/switch region; other site 813023904 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 813023905 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 813023906 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 813023907 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 813023908 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813023909 RNA binding surface [nucleotide binding]; other site 813023910 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 813023911 active site 813023912 hypothetical protein; Provisional; Region: PRK01064 813023913 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 813023914 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 813023915 DNA Topoisomerase IV; Region: TOP4c; smart00434 813023916 CAP-like domain; other site 813023917 active site 813023918 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 813023919 Glutamyl-tRNAGlu reductase, N-terminal domain; Region: GlutR_N; pfam05201 813023920 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 813023921 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 813023922 phosphopeptide binding site; other site 813023923 MARCKS family; Region: MARCKS; pfam02063 813023924 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 813023925 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 813023926 phosphopeptide binding site; other site 813023927 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 813023928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 813023929 binding surface 813023930 Tetratricopeptide repeat; Region: TPR_16; pfam13432 813023931 TPR motif; other site 813023932 type III secretion system ATPase; Provisional; Region: PRK06315 813023933 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813023934 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 813023935 Walker A motif/ATP binding site; other site 813023936 Walker B motif; other site 813023937 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 813023938 Catalytic domain of Protein Kinases; Region: PKc; cd00180 813023939 active site 813023940 ATP binding site [chemical binding]; other site 813023941 substrate binding site [chemical binding]; other site 813023942 activation loop (A-loop); other site 813023943 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 813023944 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813023945 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 813023946 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 813023947 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 813023948 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 813023949 ADP binding site [chemical binding]; other site 813023950 phosphagen binding site; other site 813023951 substrate specificity loop; other site 813023952 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 813023953 UvrB/uvrC motif; Region: UVR; pfam02151 813023954 ribosome recycling factor; Reviewed; Region: frr; PRK00083 813023955 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 813023956 hinge region; other site 813023957 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 813023958 putative nucleotide binding site [chemical binding]; other site 813023959 uridine monophosphate binding site [chemical binding]; other site 813023960 homohexameric interface [polypeptide binding]; other site 813023961 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 813023962 rRNA interaction site [nucleotide binding]; other site 813023963 S8 interaction site; other site 813023964 putative laminin-1 binding site; other site 813023965 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 813023966 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 813023967 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 813023968 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 813023969 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 813023970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813023971 TPR motif; other site 813023972 Tetratricopeptide repeat; Region: TPR_16; pfam13432 813023973 binding surface 813023974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813023975 binding surface 813023976 TPR motif; other site 813023977 TPR repeat; Region: TPR_11; pfam13414 813023978 TPR repeat; Region: TPR_11; pfam13414 813023979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813023980 binding surface 813023981 TPR motif; other site 813023982 TPR repeat; Region: TPR_11; pfam13414 813023983 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 813023984 putative ABC transporter; Region: ycf24; CHL00085 813023985 FeS assembly ATPase SufC; Region: sufC; TIGR01978 813023986 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 813023987 Walker A/P-loop; other site 813023988 ATP binding site [chemical binding]; other site 813023989 Q-loop/lid; other site 813023990 ABC transporter signature motif; other site 813023991 Walker B; other site 813023992 D-loop; other site 813023993 H-loop/switch region; other site 813023994 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 813023995 FeS assembly protein SufD; Region: sufD; TIGR01981 813023996 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 813023997 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 813023998 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813023999 catalytic residue [active] 813024000 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 813024001 ParB-like nuclease domain; Region: ParBc; pfam02195 813024002 KorB domain; Region: KorB; pfam08535 813024003 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813024004 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 813024005 Walker A/P-loop; other site 813024006 ATP binding site [chemical binding]; other site 813024007 Q-loop/lid; other site 813024008 ABC transporter signature motif; other site 813024009 Walker B; other site 813024010 D-loop; other site 813024011 H-loop/switch region; other site 813024012 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813024013 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 813024014 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 813024015 Walker A/P-loop; other site 813024016 ATP binding site [chemical binding]; other site 813024017 Q-loop/lid; other site 813024018 ABC transporter signature motif; other site 813024019 Walker B; other site 813024020 D-loop; other site 813024021 H-loop/switch region; other site 813024022 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 813024023 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 813024024 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 813024025 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 813024026 Phosphoglycerate kinase; Region: PGK; pfam00162 813024027 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 813024028 substrate binding site [chemical binding]; other site 813024029 hinge regions; other site 813024030 ADP binding site [chemical binding]; other site 813024031 catalytic site [active] 813024032 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 813024033 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 813024034 minor groove reading motif; other site 813024035 helix-hairpin-helix signature motif; other site 813024036 substrate binding pocket [chemical binding]; other site 813024037 active site 813024038 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 813024039 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 813024040 trmE is a tRNA modification GTPase; Region: trmE; cd04164 813024041 G1 box; other site 813024042 GTP/Mg2+ binding site [chemical binding]; other site 813024043 Switch I region; other site 813024044 G2 box; other site 813024045 Switch II region; other site 813024046 G3 box; other site 813024047 G4 box; other site 813024048 G5 box; other site 813024049 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 813024050 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 813024051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813024052 binding surface 813024053 TPR motif; other site 813024054 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 813024055 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 813024056 ATP binding site [chemical binding]; other site 813024057 putative Mg++ binding site [ion binding]; other site 813024058 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 813024059 Predicted GTPases [General function prediction only]; Region: COG1160 813024060 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 813024061 G1 box; other site 813024062 GTP/Mg2+ binding site [chemical binding]; other site 813024063 Switch I region; other site 813024064 G2 box; other site 813024065 Switch II region; other site 813024066 G3 box; other site 813024067 G4 box; other site 813024068 G5 box; other site 813024069 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 813024070 G1 box; other site 813024071 GTP/Mg2+ binding site [chemical binding]; other site 813024072 Switch I region; other site 813024073 G2 box; other site 813024074 G3 box; other site 813024075 Switch II region; other site 813024076 G4 box; other site 813024077 G5 box; other site 813024078 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 813024079 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 813024080 active site 813024081 NTP binding site [chemical binding]; other site 813024082 metal binding triad [ion binding]; metal-binding site 813024083 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 813024084 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 813024085 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 813024086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813024087 Walker A motif; other site 813024088 ATP binding site [chemical binding]; other site 813024089 Walker B motif; other site 813024090 arginine finger; other site 813024091 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 813024092 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 813024093 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 813024094 oligomer interface [polypeptide binding]; other site 813024095 active site residues [active] 813024096 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 813024097 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 813024098 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 813024099 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 813024100 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813024101 ATP binding site [chemical binding]; other site 813024102 putative Mg++ binding site [ion binding]; other site 813024103 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813024104 nucleotide binding region [chemical binding]; other site 813024105 ATP-binding site [chemical binding]; other site 813024106 rod shape-determining protein MreB; Provisional; Region: PRK13927 813024107 MreB and similar proteins; Region: MreB_like; cd10225 813024108 nucleotide binding site [chemical binding]; other site 813024109 Mg binding site [ion binding]; other site 813024110 putative protofilament interaction site [polypeptide binding]; other site 813024111 RodZ interaction site [polypeptide binding]; other site 813024112 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 813024113 active site 813024114 substrate-binding site [chemical binding]; other site 813024115 metal-binding site [ion binding] 813024116 GTP binding site [chemical binding]; other site 813024117 Effector from type III secretion system; Region: Effector_1; pfam04518 813024118 Effector from type III secretion system; Region: Effector_1; pfam04518 813024119 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 813024120 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 813024121 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 813024122 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 813024123 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 813024124 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 813024125 active site 813024126 AAA domain; Region: AAA_13; pfam13166 813024127 type III secretion system ATPase; Validated; Region: PRK05922 813024128 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 813024129 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 813024130 Walker A motif; other site 813024131 ATP binding site [chemical binding]; other site 813024132 Walker B motif; other site 813024133 type III secretion system protein; Validated; Region: PRK05934 813024134 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 813024135 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 813024136 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 813024137 active site 813024138 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 813024139 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 813024140 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813024141 catalytic residue [active] 813024142 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 813024143 catalytic core [active] 813024144 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 813024145 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 813024146 RNA binding surface [nucleotide binding]; other site 813024147 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 813024148 active site 813024149 biotin--protein ligase; Provisional; Region: PRK05935 813024150 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 813024151 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 813024152 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 813024153 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 813024154 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 813024155 motif II; other site 813024156 CCC1-related protein family; Region: CCC1_like_1; cd02437 813024157 seryl-tRNA synthetase; Provisional; Region: PRK05431 813024158 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 813024159 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 813024160 dimer interface [polypeptide binding]; other site 813024161 active site 813024162 motif 1; other site 813024163 motif 2; other site 813024164 motif 3; other site 813024165 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 813024166 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 813024167 catalytic motif [active] 813024168 Zn binding site [ion binding]; other site 813024169 RibD C-terminal domain; Region: RibD_C; pfam01872 813024170 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 813024171 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 813024172 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 813024173 dimerization interface [polypeptide binding]; other site 813024174 active site 813024175 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 813024176 homopentamer interface [polypeptide binding]; other site 813024177 active site 813024178 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 813024179 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 813024180 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 813024181 substrate binding site [chemical binding]; other site 813024182 Proteins containing SET domain [General function prediction only]; Region: COG2940 813024183 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 813024184 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 813024185 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 813024186 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 813024187 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 813024188 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 813024189 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 813024190 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 813024191 catalytic loop [active] 813024192 iron binding site [ion binding]; other site 813024193 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 813024194 FAD binding pocket [chemical binding]; other site 813024195 FAD binding motif [chemical binding]; other site 813024196 phosphate binding motif [ion binding]; other site 813024197 beta-alpha-beta structure motif; other site 813024198 NAD binding pocket [chemical binding]; other site 813024199 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 813024200 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 813024201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 813024202 S-adenosylmethionine binding site [chemical binding]; other site 813024203 Histone H1-like protein Hc1; Region: Hc1; pfam07432 813024204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813024205 binding surface 813024206 TPR motif; other site 813024207 Tetratricopeptide repeat; Region: TPR_12; pfam13424 813024208 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 813024209 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 813024210 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 813024211 HemN C-terminal domain; Region: HemN_C; pfam06969 813024212 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 813024213 substrate binding site [chemical binding]; other site 813024214 active site 813024215 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 813024216 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 813024217 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813024218 ATP binding site [chemical binding]; other site 813024219 putative Mg++ binding site [ion binding]; other site 813024220 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 813024221 nucleotide binding region [chemical binding]; other site 813024222 ATP-binding site [chemical binding]; other site 813024223 TRCF domain; Region: TRCF; pfam03461 813024224 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 813024225 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 813024226 motif 1; other site 813024227 active site 813024228 motif 2; other site 813024229 motif 3; other site 813024230 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 813024231 DHHA1 domain; Region: DHHA1; pfam02272 813024232 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 813024233 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 813024234 TPP-binding site [chemical binding]; other site 813024235 dimer interface [polypeptide binding]; other site 813024236 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 813024237 PYR/PP interface [polypeptide binding]; other site 813024238 dimer interface [polypeptide binding]; other site 813024239 TPP binding site [chemical binding]; other site 813024240 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 813024241 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 813024242 elongation factor P; Validated; Region: PRK00529 813024243 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 813024244 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 813024245 RNA binding site [nucleotide binding]; other site 813024246 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 813024247 RNA binding site [nucleotide binding]; other site 813024248 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 813024249 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 813024250 putative active site [active] 813024251 putative metal binding site [ion binding]; other site 813024252 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 813024253 active site 813024254 metal binding site [ion binding]; metal-binding site 813024255 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 813024256 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 813024257 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 813024258 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813024259 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813024260 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 813024261 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 813024262 Mg++ binding site [ion binding]; other site 813024263 putative catalytic motif [active] 813024264 putative substrate binding site [chemical binding]; other site 813024265 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 813024266 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 813024267 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 813024268 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 813024269 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 813024270 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813024271 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 813024272 cell division protein FtsW; Region: ftsW; TIGR02614 813024273 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 813024274 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 813024275 active site 813024276 homodimer interface [polypeptide binding]; other site 813024277 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 813024278 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409 813024279 G-X-X-G motif; other site 813024280 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 813024281 anti sigma factor interaction site; other site 813024282 regulatory phosphorylation site [posttranslational modification]; other site 813024283 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 813024284 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 813024285 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813024286 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 813024287 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 813024288 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 813024289 dimer interface [polypeptide binding]; other site 813024290 active site 813024291 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 813024292 active site 813024293 Ap4A binding cleft/pocket [chemical binding]; other site 813024294 P4 phosphate binding site; other site 813024295 nudix motif; other site 813024296 putative P2/P3 phosphate binding site [ion binding]; other site 813024297 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 813024298 dimer interface [polypeptide binding]; other site 813024299 substrate binding site [chemical binding]; other site 813024300 metal binding sites [ion binding]; metal-binding site 813024301 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 813024302 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 813024303 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 813024304 NAD binding site [chemical binding]; other site 813024305 Phe binding site; other site 813024306 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 813024307 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 813024308 active site 813024309 putative lithium-binding site [ion binding]; other site 813024310 substrate binding site [chemical binding]; other site 813024311 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 813024312 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 813024313 putative acyl-acceptor binding pocket; other site 813024314 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 813024315 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 813024316 acyl-activating enzyme (AAE) consensus motif; other site 813024317 AMP binding site [chemical binding]; other site 813024318 active site 813024319 CoA binding site [chemical binding]; other site 813024320 8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937 813024321 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 813024322 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 813024323 catalytic residue [active] 813024324 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 813024325 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 813024326 ATP binding site [chemical binding]; other site 813024327 putative Mg++ binding site [ion binding]; other site 813024328 helicase superfamily c-terminal domain; Region: HELICc; smart00490 813024329 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 813024330 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813024331 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 813024332 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 813024333 dimer interface [polypeptide binding]; other site 813024334 putative anticodon binding site; other site 813024335 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 813024336 motif 1; other site 813024337 dimer interface [polypeptide binding]; other site 813024338 active site 813024339 motif 2; other site 813024340 motif 3; other site 813024341 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 813024342 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 813024343 active site 813024344 HIGH motif; other site 813024345 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 813024346 KMSKS motif; other site 813024347 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813024348 tRNA binding surface [nucleotide binding]; other site 813024349 anticodon binding site; other site 813024350 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 813024351 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 813024352 ribonuclease P; Reviewed; Region: rnpA; PRK00730 813024353 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 813024354 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 813024355 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 813024356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 813024357 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 813024358 MutS domain I; Region: MutS_I; pfam01624 813024359 MutS domain II; Region: MutS_II; pfam05188 813024360 MutS domain III; Region: MutS_III; pfam05192 813024361 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 813024362 Walker A/P-loop; other site 813024363 ATP binding site [chemical binding]; other site 813024364 Q-loop/lid; other site 813024365 ABC transporter signature motif; other site 813024366 Walker B; other site 813024367 D-loop; other site 813024368 H-loop/switch region; other site 813024369 DNA primase; Validated; Region: dnaG; PRK05667 813024370 CHC2 zinc finger; Region: zf-CHC2; pfam01807 813024371 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 813024372 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 813024373 active site 813024374 metal binding site [ion binding]; metal-binding site 813024375 interdomain interaction site; other site 813024376 glycyl-tRNA synthetase; Provisional; Region: PRK14908 813024377 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 813024378 dimer interface [polypeptide binding]; other site 813024379 motif 1; other site 813024380 active site 813024381 motif 2; other site 813024382 motif 3; other site 813024383 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 813024384 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 813024385 glycogen synthase; Provisional; Region: glgA; PRK00654 813024386 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 813024387 ADP-binding pocket [chemical binding]; other site 813024388 homodimer interface [polypeptide binding]; other site 813024389 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 813024390 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 813024391 5S rRNA interface [nucleotide binding]; other site 813024392 CTC domain interface [polypeptide binding]; other site 813024393 L16 interface [polypeptide binding]; other site 813024394 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 813024395 putative active site [active] 813024396 catalytic residue [active] 813024397 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 813024398 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 813024399 Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359 813024400 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 813024401 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 813024402 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 813024403 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 813024404 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 813024405 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813024406 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813024407 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 813024408 putative acyl-acceptor binding pocket; other site 813024409 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 813024410 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 813024411 homodimer interface [polypeptide binding]; other site 813024412 oligonucleotide binding site [chemical binding]; other site 813024413 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 813024414 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 813024415 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813024416 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813024417 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 813024418 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 813024419 active site 813024420 substrate binding site [chemical binding]; other site 813024421 metal binding site [ion binding]; metal-binding site 813024422 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 813024423 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 813024424 glutaminase active site [active] 813024425 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 813024426 dimer interface [polypeptide binding]; other site 813024427 active site 813024428 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 813024429 dimer interface [polypeptide binding]; other site 813024430 active site 813024431 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 813024432 aromatic amino acid transport protein; Region: araaP; TIGR00837 813024433 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 813024434 aromatic amino acid transport protein; Region: araaP; TIGR00837 813024435 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 813024436 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 813024437 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 813024438 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 813024439 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 813024440 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 813024441 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 813024442 CoA-ligase; Region: Ligase_CoA; pfam00549 813024443 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 813024444 CoA binding domain; Region: CoA_binding; smart00881 813024445 CoA-ligase; Region: Ligase_CoA; pfam00549 813024446 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 813024447 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 813024448 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 813024449 protein binding site [polypeptide binding]; other site 813024450 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 813024451 protein binding site [polypeptide binding]; other site 813024452 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 813024453 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 813024454 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813024455 Peptidase M16C associated; Region: M16C_assoc; pfam08367 813024456 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 813024457 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 813024458 RmuC family; Region: RmuC; pfam02646 813024459 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 813024460 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 813024461 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 813024462 ATP cone domain; Region: ATP-cone; pfam03477 813024463 ATP cone domain; Region: ATP-cone; pfam03477 813024464 Class I ribonucleotide reductase; Region: RNR_I; cd01679 813024465 active site 813024466 dimer interface [polypeptide binding]; other site 813024467 catalytic residues [active] 813024468 effector binding site; other site 813024469 R2 peptide binding site; other site 813024470 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 813024471 dimer interface [polypeptide binding]; other site 813024472 putative radical transfer pathway; other site 813024473 diiron center [ion binding]; other site 813024474 tyrosyl radical; other site 813024475 Putative methyltransferase; Region: Methyltransf_4; pfam02390 813024476 Methyltransferase domain; Region: Methyltransf_18; pfam12847 813024477 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 813024478 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 813024479 FAD binding domain; Region: FAD_binding_4; pfam01565 813024480 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 813024481 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 813024482 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 813024483 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 813024484 Ribosomal protein L35 [Translation, ribosomal structure and biogenesis]; Region: RpmI; COG0291 813024485 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 813024486 23S rRNA binding site [nucleotide binding]; other site 813024487 L21 binding site [polypeptide binding]; other site 813024488 L13 binding site [polypeptide binding]; other site 813024489 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 813024490 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 813024491 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 813024492 motif 1; other site 813024493 dimer interface [polypeptide binding]; other site 813024494 active site 813024495 motif 2; other site 813024496 motif 3; other site 813024497 Predicted permeases [General function prediction only]; Region: COG0795 813024498 Predicted permeases [General function prediction only]; Region: COG0795 813024499 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 813024500 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 813024501 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 813024502 Ligand Binding Site [chemical binding]; other site 813024503 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 813024504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 813024505 Walker A motif; other site 813024506 ATP binding site [chemical binding]; other site 813024507 Walker B motif; other site 813024508 arginine finger; other site 813024509 Peptidase family M41; Region: Peptidase_M41; pfam01434 813024510 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 813024511 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 813024512 RNase E interface [polypeptide binding]; other site 813024513 trimer interface [polypeptide binding]; other site 813024514 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 813024515 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 813024516 RNase E interface [polypeptide binding]; other site 813024517 trimer interface [polypeptide binding]; other site 813024518 active site 813024519 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 813024520 putative nucleic acid binding region [nucleotide binding]; other site 813024521 G-X-X-G motif; other site 813024522 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 813024523 RNA binding site [nucleotide binding]; other site 813024524 domain interface; other site 813024525 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 813024526 16S/18S rRNA binding site [nucleotide binding]; other site 813024527 S13e-L30e interaction site [polypeptide binding]; other site 813024528 25S rRNA binding site [nucleotide binding]; other site 813024529 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 813024530 nucleoside/Zn binding site; other site 813024531 dimer interface [polypeptide binding]; other site 813024532 catalytic motif [active] 813024533 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813024534 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813024535 Protein of unknown function (DUF720); Region: DUF720; pfam05302 813024536 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 813024537 methionine aminopeptidase; Provisional; Region: PRK12318 813024538 SEC-C motif; Region: SEC-C; pfam02810 813024539 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 813024540 active site 813024541 MarC family integral membrane protein; Region: MarC; pfam01914 813024542 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 813024543 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 813024544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 813024545 dimer interface [polypeptide binding]; other site 813024546 conserved gate region; other site 813024547 putative PBP binding loops; other site 813024548 ABC-ATPase subunit interface; other site 813024549 NMT1/THI5 like; Region: NMT1; pfam09084 813024550 fumarate hydratase, class II; Region: fumC_II; TIGR00979 813024551 Class II fumarases; Region: Fumarase_classII; cd01362 813024552 active site 813024553 tetramer interface [polypeptide binding]; other site 813024554 high affinity sulphate transporter 1; Region: sulP; TIGR00815 813024555 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 813024556 Sulfate transporter family; Region: Sulfate_transp; pfam00916 813024557 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 813024558 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 813024559 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 813024560 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 813024561 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 813024562 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 813024563 active site triad [active] 813024564 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 813024565 LytB protein; Region: LYTB; pfam02401 813024566 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 813024567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 813024568 binding surface 813024569 TPR motif; other site 813024570 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 813024571 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 813024572 active site 813024573 DNA binding site [nucleotide binding] 813024574 Int/Topo IB signature motif; other site 813024575 glycogen branching enzyme; Provisional; Region: PRK05402 813024576 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 813024577 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 813024578 active site 813024579 catalytic site [active] 813024580 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 813024581 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 813024582 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 813024583 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813024584 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813024585 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813024586 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813024587 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813024588 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813024589 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813024590 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813024591 Autotransporter beta-domain; Region: Autotransporter; pfam03797 813024592 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813024593 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813024594 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 813024595 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 813024596 Autotransporter beta-domain; Region: Autotransporter; pfam03797