-- dump date 20140619_033152 -- class Genbank::misc_feature -- table misc_feature_note -- id note 707185000001 Uncharacterized conserved protein [Function unknown]; Region: COG2155 707185000002 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 707185000003 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 707185000004 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 707185000005 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 707185000006 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 707185000007 GatB domain; Region: GatB_Yqey; pfam02637 707185000008 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 707185000009 ribonuclease HIII; Region: rnhC; TIGR00716 707185000010 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 707185000011 RNA/DNA hybrid binding site [nucleotide binding]; other site 707185000012 active site 707185000013 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 707185000014 Helix-turn-helix domain; Region: HTH_25; pfam13413 707185000015 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906 707185000016 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 707185000017 putative acyl-acceptor binding pocket; other site 707185000018 Uncharacterized conserved protein [Function unknown]; Region: COG1624 707185000019 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 707185000020 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 707185000021 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 707185000022 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 707185000023 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 707185000024 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 707185000025 putative active site [active] 707185000026 PhoH-like protein; Region: PhoH; pfam02562 707185000027 Bacterial SH3 domain homologues; Region: SH3b; smart00287 707185000028 Bacterial SH3 domain homologues; Region: SH3b; smart00287 707185000029 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 707185000030 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 707185000031 HIGH motif; other site 707185000032 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 707185000033 active site 707185000034 KMSKS motif; other site 707185000035 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 707185000036 tRNA binding surface [nucleotide binding]; other site 707185000037 anticodon binding site; other site 707185000038 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 707185000039 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 707185000040 Catalytic site [active] 707185000041 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 707185000042 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 707185000043 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 707185000044 peptide chain release factor 1; Validated; Region: prfA; PRK00591 707185000045 PCRF domain; Region: PCRF; pfam03462 707185000046 RF-1 domain; Region: RF-1; pfam00472 707185000047 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 707185000048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707185000049 S-adenosylmethionine binding site [chemical binding]; other site 707185000050 signal recognition particle protein; Provisional; Region: PRK10867 707185000051 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 707185000052 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 707185000053 P loop; other site 707185000054 GTP binding site [chemical binding]; other site 707185000055 Signal peptide binding domain; Region: SRP_SPB; pfam02978 707185000056 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 707185000057 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 707185000058 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 707185000059 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 707185000060 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 707185000061 RNA/DNA hybrid binding site [nucleotide binding]; other site 707185000062 active site 707185000063 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 707185000064 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 707185000065 catalytic site [active] 707185000066 G-X2-G-X-G-K; other site 707185000067 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 707185000068 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 707185000069 active site 707185000070 HIGH motif; other site 707185000071 KMSKS motif; other site 707185000072 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 707185000073 tRNA binding surface [nucleotide binding]; other site 707185000074 anticodon binding site; other site 707185000075 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 707185000076 AAA domain; Region: AAA_30; pfam13604 707185000077 Family description; Region: UvrD_C_2; pfam13538 707185000078 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 707185000079 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 707185000080 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 707185000081 conserved cys residue [active] 707185000082 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 707185000083 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 707185000084 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 707185000085 trimer interface [polypeptide binding]; other site 707185000086 active site 707185000087 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 707185000088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707185000089 Walker A motif; other site 707185000090 ATP binding site [chemical binding]; other site 707185000091 Walker B motif; other site 707185000092 arginine finger; other site 707185000093 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 707185000094 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 707185000095 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 707185000096 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 707185000097 active site 707185000098 catalytic site [active] 707185000099 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 707185000100 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 707185000101 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 707185000102 dimer interface [polypeptide binding]; other site 707185000103 ssDNA binding site [nucleotide binding]; other site 707185000104 tetramer (dimer of dimers) interface [polypeptide binding]; other site 707185000105 multifunctional aminopeptidase A; Provisional; Region: PRK00913 707185000106 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 707185000107 interface (dimer of trimers) [polypeptide binding]; other site 707185000108 Substrate-binding/catalytic site; other site 707185000109 Zn-binding sites [ion binding]; other site 707185000110 hypothetical protein; Provisional; Region: PRK05907 707185000111 Predicted methyltransferases [General function prediction only]; Region: COG0313 707185000112 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 707185000113 putative SAM binding site [chemical binding]; other site 707185000114 homodimer interface [polypeptide binding]; other site 707185000115 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 707185000116 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 707185000117 FeS/SAM binding site; other site 707185000118 HemN C-terminal domain; Region: HemN_C; pfam06969 707185000119 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 707185000120 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 707185000121 TPP-binding site [chemical binding]; other site 707185000122 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 707185000123 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 707185000124 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 707185000125 E3 interaction surface; other site 707185000126 lipoyl attachment site [posttranslational modification]; other site 707185000127 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 707185000128 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 707185000129 uncharacterized protein, YfiH family; Region: TIGR00726 707185000130 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 707185000131 1-hydroxy-2-methyl-2-(e)-butenyl 4-diphosphate synthase [Lipid metabolism]; Region: gcpE; COG0821 707185000132 IncA protein; Region: IncA; pfam04156 707185000133 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 707185000134 ADP-ribose binding site [chemical binding]; other site 707185000135 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 707185000136 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 707185000137 catalytic loop [active] 707185000138 iron binding site [ion binding]; other site 707185000139 type III secretion system protein; Validated; Region: PRK05910 707185000140 FHIPEP family; Region: FHIPEP; pfam00771 707185000141 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 707185000142 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 707185000143 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 707185000144 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 707185000145 DNA binding residues [nucleotide binding] 707185000146 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 707185000147 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 707185000148 active site 707185000149 HIGH motif; other site 707185000150 dimer interface [polypeptide binding]; other site 707185000151 KMSKS motif; other site 707185000152 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 707185000153 RNA binding surface [nucleotide binding]; other site 707185000154 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 707185000155 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 707185000156 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 707185000157 GTP-binding protein LepA; Provisional; Region: PRK05433 707185000158 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 707185000159 G1 box; other site 707185000160 putative GEF interaction site [polypeptide binding]; other site 707185000161 GTP/Mg2+ binding site [chemical binding]; other site 707185000162 Switch I region; other site 707185000163 G2 box; other site 707185000164 G3 box; other site 707185000165 Switch II region; other site 707185000166 G4 box; other site 707185000167 G5 box; other site 707185000168 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 707185000169 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 707185000170 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 707185000171 ADP/ATP carrier protein family; Region: AAA; TIGR00769 707185000172 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 707185000173 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 707185000174 intersubunit interface [polypeptide binding]; other site 707185000175 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 707185000176 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 707185000177 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 707185000178 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 707185000179 ABC-ATPase subunit interface; other site 707185000180 dimer interface [polypeptide binding]; other site 707185000181 putative PBP binding regions; other site 707185000182 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 707185000183 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 707185000184 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 707185000185 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 707185000186 ABC-ATPase subunit interface; other site 707185000187 dimer interface [polypeptide binding]; other site 707185000188 putative PBP binding regions; other site 707185000189 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 707185000190 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 707185000191 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 707185000192 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 707185000193 RIP metalloprotease RseP; Region: TIGR00054 707185000194 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 707185000195 active site 707185000196 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 707185000197 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 707185000198 putative substrate binding region [chemical binding]; other site 707185000199 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 707185000200 Putative serine esterase (DUF676); Region: DUF676; pfam05057 707185000201 recF protein; Region: recf; TIGR00611 707185000202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707185000203 Walker A/P-loop; other site 707185000204 ATP binding site [chemical binding]; other site 707185000205 Q-loop/lid; other site 707185000206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707185000207 ABC transporter signature motif; other site 707185000208 Walker B; other site 707185000209 DNA polymerase III subunit beta; Validated; Region: PRK05643 707185000210 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 707185000211 putative DNA binding surface [nucleotide binding]; other site 707185000212 dimer interface [polypeptide binding]; other site 707185000213 beta-clamp/clamp loader binding surface; other site 707185000214 beta-clamp/translesion DNA polymerase binding surface; other site 707185000215 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 707185000216 SmpB-tmRNA interface; other site 707185000217 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 707185000218 ApbE family; Region: ApbE; pfam02424 707185000219 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 707185000220 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 707185000221 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 707185000222 homodimer interface [polypeptide binding]; other site 707185000223 NADP binding site [chemical binding]; other site 707185000224 substrate binding site [chemical binding]; other site 707185000225 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 707185000226 PLD-like domain; Region: PLDc_2; pfam13091 707185000227 putative active site [active] 707185000228 catalytic site [active] 707185000229 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 707185000230 PLD-like domain; Region: PLDc_2; pfam13091 707185000231 putative active site [active] 707185000232 catalytic site [active] 707185000233 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 707185000234 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 707185000235 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 707185000236 4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446 707185000237 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 707185000238 HrpJ-like domain; Region: HrpJ; cl15454 707185000239 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 707185000240 FHIPEP family; Region: FHIPEP; pfam00771 707185000241 type III secretion system protein; Validated; Region: PRK06298 707185000242 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 707185000243 GTP-binding protein YchF; Reviewed; Region: PRK09601 707185000244 YchF GTPase; Region: YchF; cd01900 707185000245 G1 box; other site 707185000246 GTP/Mg2+ binding site [chemical binding]; other site 707185000247 Switch I region; other site 707185000248 G2 box; other site 707185000249 Switch II region; other site 707185000250 G3 box; other site 707185000251 G4 box; other site 707185000252 G5 box; other site 707185000253 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 707185000254 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 707185000255 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 707185000256 active site 707185000257 Riboflavin kinase; Region: Flavokinase; smart00904 707185000258 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 707185000259 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 707185000260 RNA binding site [nucleotide binding]; other site 707185000261 active site 707185000262 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 707185000263 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 707185000264 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 707185000265 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 707185000266 G1 box; other site 707185000267 putative GEF interaction site [polypeptide binding]; other site 707185000268 GTP/Mg2+ binding site [chemical binding]; other site 707185000269 Switch I region; other site 707185000270 G2 box; other site 707185000271 G3 box; other site 707185000272 Switch II region; other site 707185000273 G4 box; other site 707185000274 G5 box; other site 707185000275 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 707185000276 Translation-initiation factor 2; Region: IF-2; pfam11987 707185000277 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 707185000278 transcription termination factor NusA; Region: NusA; TIGR01953 707185000279 NusA N-terminal domain; Region: NusA_N; pfam08529 707185000280 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 707185000281 RNA binding site [nucleotide binding]; other site 707185000282 homodimer interface [polypeptide binding]; other site 707185000283 NusA-like KH domain; Region: KH_5; pfam13184 707185000284 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 707185000285 G-X-X-G motif; other site 707185000286 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 707185000287 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 707185000288 RNA binding site [nucleotide binding]; other site 707185000289 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 707185000290 RNA binding site [nucleotide binding]; other site 707185000291 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 707185000292 RNA binding site [nucleotide binding]; other site 707185000293 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 707185000294 RNA binding site [nucleotide binding]; other site 707185000295 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 707185000296 RNA binding site [nucleotide binding]; other site 707185000297 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 707185000298 RNA binding site [nucleotide binding]; other site 707185000299 domain interface; other site 707185000300 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 707185000301 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 707185000302 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 707185000303 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 707185000304 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 707185000305 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 707185000306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 707185000307 active site 707185000308 motif I; other site 707185000309 motif II; other site 707185000310 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 707185000311 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 707185000312 NAD binding site [chemical binding]; other site 707185000313 homotetramer interface [polypeptide binding]; other site 707185000314 homodimer interface [polypeptide binding]; other site 707185000315 substrate binding site [chemical binding]; other site 707185000316 active site 707185000317 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 707185000318 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 707185000319 RNA binding surface [nucleotide binding]; other site 707185000320 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 707185000321 active site 707185000322 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 707185000323 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 707185000324 minor groove reading motif; other site 707185000325 helix-hairpin-helix signature motif; other site 707185000326 substrate binding pocket [chemical binding]; other site 707185000327 active site 707185000328 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 707185000329 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 707185000330 DNA binding and oxoG recognition site [nucleotide binding] 707185000331 Uncharacterized conserved protein [Function unknown]; Region: COG0327 707185000332 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 707185000333 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 707185000334 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 707185000335 ring oligomerisation interface [polypeptide binding]; other site 707185000336 ATP/Mg binding site [chemical binding]; other site 707185000337 stacking interactions; other site 707185000338 hinge regions; other site 707185000339 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 707185000340 oligomerisation interface [polypeptide binding]; other site 707185000341 mobile loop; other site 707185000342 roof hairpin; other site 707185000343 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 707185000344 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 707185000345 active site 707185000346 Zn binding site [ion binding]; other site 707185000347 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 707185000348 Clp amino terminal domain; Region: Clp_N; pfam02861 707185000349 Clp amino terminal domain; Region: Clp_N; pfam02861 707185000350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707185000351 Walker A motif; other site 707185000352 ATP binding site [chemical binding]; other site 707185000353 Walker B motif; other site 707185000354 arginine finger; other site 707185000355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707185000356 Walker A motif; other site 707185000357 ATP binding site [chemical binding]; other site 707185000358 Walker B motif; other site 707185000359 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 707185000360 Uncharacterized conserved protein [Function unknown]; Region: COG2912 707185000361 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 707185000362 IncA protein; Region: IncA; pfam04156 707185000363 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 707185000364 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 707185000365 substrate binding site [chemical binding]; other site 707185000366 hexamer interface [polypeptide binding]; other site 707185000367 metal binding site [ion binding]; metal-binding site 707185000368 elongation factor P; Provisional; Region: PRK12426 707185000369 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 707185000370 RNA binding site [nucleotide binding]; other site 707185000371 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 707185000372 RNA binding site [nucleotide binding]; other site 707185000373 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 707185000374 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 707185000375 carboxyltransferase (CT) interaction site; other site 707185000376 biotinylation site [posttranslational modification]; other site 707185000377 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 707185000378 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 707185000379 ATP-grasp domain; Region: ATP-grasp_4; cl17255 707185000380 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 707185000381 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 707185000382 23S rRNA interface [nucleotide binding]; other site 707185000383 L3 interface [polypeptide binding]; other site 707185000384 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 707185000385 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 707185000386 NlpC/P60 family; Region: NLPC_P60; cl17555 707185000387 adenylate kinase; Region: adk; TIGR01351 707185000388 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 707185000389 AMP-binding site [chemical binding]; other site 707185000390 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 707185000391 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 707185000392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707185000393 dimer interface [polypeptide binding]; other site 707185000394 conserved gate region; other site 707185000395 putative PBP binding loops; other site 707185000396 ABC-ATPase subunit interface; other site 707185000397 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 707185000398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707185000399 Walker A/P-loop; other site 707185000400 ATP binding site [chemical binding]; other site 707185000401 Q-loop/lid; other site 707185000402 ABC transporter signature motif; other site 707185000403 Walker B; other site 707185000404 D-loop; other site 707185000405 H-loop/switch region; other site 707185000406 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 707185000407 Methyltransferase domain; Region: Methyltransf_23; pfam13489 707185000408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707185000409 S-adenosylmethionine binding site [chemical binding]; other site 707185000410 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 707185000411 Serine hydrolase (FSH1); Region: FSH1; pfam03959 707185000412 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 707185000413 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 707185000414 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 707185000415 active site 707185000416 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 707185000417 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 707185000418 conserved hypothetical integral membrane protein; Region: TIGR00697 707185000419 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 707185000420 SEC-C motif; Region: SEC-C; pfam02810 707185000421 potential protein location (hypothetical protein G9768_00730 [Chlamydia trachomatis G/9768]) that overlaps RNA (tRNA-T) 707185000422 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 707185000423 Catalytic domain of Protein Kinases; Region: PKc; cd00180 707185000424 active site 707185000425 ATP binding site [chemical binding]; other site 707185000426 substrate binding site [chemical binding]; other site 707185000427 activation loop (A-loop); other site 707185000428 Uncharacterized conserved protein [Function unknown]; Region: COG1262 707185000429 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 707185000430 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 707185000431 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 707185000432 nucleotide binding pocket [chemical binding]; other site 707185000433 K-X-D-G motif; other site 707185000434 catalytic site [active] 707185000435 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 707185000436 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 707185000437 Helix-hairpin-helix motif; Region: HHH; pfam00633 707185000438 helix-hairpin-helix signature motif; other site 707185000439 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 707185000440 Dimer interface [polypeptide binding]; other site 707185000441 BRCT sequence motif; other site 707185000442 hypothetical protein; Provisional; Region: PRK06184 707185000443 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 707185000444 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 707185000445 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 707185000446 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 707185000447 FtsX-like permease family; Region: FtsX; pfam02687 707185000448 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 707185000449 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 707185000450 Walker A/P-loop; other site 707185000451 ATP binding site [chemical binding]; other site 707185000452 Q-loop/lid; other site 707185000453 ABC transporter signature motif; other site 707185000454 Walker B; other site 707185000455 D-loop; other site 707185000456 H-loop/switch region; other site 707185000457 membrane-attack complex / perforin; Region: MACPF; smart00457 707185000458 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 707185000459 potential frameshift: common BLAST hit: gi|15604873|ref|NP_219657.1| phospholipase D endonuclease superfamily protein 707185000460 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 707185000461 PLD-like domain; Region: PLDc_2; pfam13091 707185000462 putative active site [active] 707185000463 catalytic site [active] 707185000464 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 707185000465 PLD-like domain; Region: PLDc_2; pfam13091 707185000466 putative active site [active] 707185000467 catalytic site [active] 707185000468 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 707185000469 PLD-like domain; Region: PLDc_2; pfam13091 707185000470 putative active site [active] 707185000471 catalytic site [active] 707185000472 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 707185000473 PLD-like domain; Region: PLDc_2; pfam13091 707185000474 putative active site [active] 707185000475 catalytic site [active] 707185000476 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 707185000477 PLD-like domain; Region: PLDc_2; pfam13091 707185000478 putative active site [active] 707185000479 catalytic site [active] 707185000480 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 707185000481 potential frameshift: common BLAST hit: gi|15835056|ref|NP_296815.1| adherence factor 707185000482 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 707185000483 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 707185000484 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 707185000485 trp operon repressor, proteobacterial; Region: TrpR; TIGR01321 707185000486 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 707185000487 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 707185000488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707185000489 catalytic residue [active] 707185000490 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 707185000491 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 707185000492 substrate binding site [chemical binding]; other site 707185000493 active site 707185000494 catalytic residues [active] 707185000495 heterodimer interface [polypeptide binding]; other site 707185000496 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 707185000497 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 707185000498 peptide binding site [polypeptide binding]; other site 707185000499 putative disulfide oxidoreductase; Provisional; Region: PRK00611 707185000500 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 707185000501 Thioredoxin; Region: Thioredoxin_4; cl17273 707185000502 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 707185000503 putative active site [active] 707185000504 redox center [active] 707185000505 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 707185000506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707185000507 Walker A/P-loop; other site 707185000508 ATP binding site [chemical binding]; other site 707185000509 Q-loop/lid; other site 707185000510 ABC transporter signature motif; other site 707185000511 Walker B; other site 707185000512 D-loop; other site 707185000513 H-loop/switch region; other site 707185000514 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 707185000515 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 707185000516 Ligand binding site; other site 707185000517 oligomer interface; other site 707185000518 CTP synthetase; Validated; Region: pyrG; PRK05380 707185000519 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 707185000520 Catalytic site [active] 707185000521 active site 707185000522 UTP binding site [chemical binding]; other site 707185000523 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 707185000524 active site 707185000525 putative oxyanion hole; other site 707185000526 catalytic triad [active] 707185000527 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 707185000528 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 707185000529 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 707185000530 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 707185000531 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 707185000532 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 707185000533 putative active site [active] 707185000534 DNA polymerase III subunit delta'; Validated; Region: PRK05917 707185000535 DNA polymerase III subunit delta'; Validated; Region: PRK08485 707185000536 thymidylate kinase; Validated; Region: tmk; PRK00698 707185000537 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 707185000538 TMP-binding site; other site 707185000539 ATP-binding site [chemical binding]; other site 707185000540 DNA gyrase, A subunit; Region: gyrA; TIGR01063 707185000541 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 707185000542 CAP-like domain; other site 707185000543 active site 707185000544 primary dimer interface [polypeptide binding]; other site 707185000545 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 707185000546 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 707185000547 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 707185000548 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 707185000549 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 707185000550 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 707185000551 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 707185000552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 707185000553 ATP binding site [chemical binding]; other site 707185000554 Mg2+ binding site [ion binding]; other site 707185000555 G-X-G motif; other site 707185000556 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 707185000557 anchoring element; other site 707185000558 dimer interface [polypeptide binding]; other site 707185000559 ATP binding site [chemical binding]; other site 707185000560 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 707185000561 active site 707185000562 putative metal-binding site [ion binding]; other site 707185000563 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 707185000564 Protein of unknown function (DUF721); Region: DUF721; pfam05258 707185000565 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 707185000566 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 707185000567 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 707185000568 MgtE intracellular N domain; Region: MgtE_N; pfam03448 707185000569 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 707185000570 Divalent cation transporter; Region: MgtE; pfam01769 707185000571 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 707185000572 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 707185000573 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 707185000574 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 707185000575 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 707185000576 peptide binding site [polypeptide binding]; other site 707185000577 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 707185000578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707185000579 dimer interface [polypeptide binding]; other site 707185000580 conserved gate region; other site 707185000581 putative PBP binding loops; other site 707185000582 ABC-ATPase subunit interface; other site 707185000583 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 707185000584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707185000585 dimer interface [polypeptide binding]; other site 707185000586 conserved gate region; other site 707185000587 putative PBP binding loops; other site 707185000588 ABC-ATPase subunit interface; other site 707185000589 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 707185000590 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 707185000591 Walker A/P-loop; other site 707185000592 ATP binding site [chemical binding]; other site 707185000593 Q-loop/lid; other site 707185000594 ABC transporter signature motif; other site 707185000595 Walker B; other site 707185000596 D-loop; other site 707185000597 H-loop/switch region; other site 707185000598 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 707185000599 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 707185000600 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 707185000601 Walker A/P-loop; other site 707185000602 ATP binding site [chemical binding]; other site 707185000603 Q-loop/lid; other site 707185000604 ABC transporter signature motif; other site 707185000605 Walker B; other site 707185000606 D-loop; other site 707185000607 H-loop/switch region; other site 707185000608 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 707185000609 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 707185000610 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 707185000611 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 707185000612 transmembrane helices; other site 707185000613 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 707185000614 active site 707185000615 ADP/pyrophosphate binding site [chemical binding]; other site 707185000616 dimerization interface [polypeptide binding]; other site 707185000617 allosteric effector site; other site 707185000618 fructose-1,6-bisphosphate binding site; other site 707185000619 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 707185000620 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 707185000621 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 707185000622 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 707185000623 active site 707185000624 ADP/pyrophosphate binding site [chemical binding]; other site 707185000625 dimerization interface [polypeptide binding]; other site 707185000626 allosteric effector site; other site 707185000627 fructose-1,6-bisphosphate binding site; other site 707185000628 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 707185000629 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 707185000630 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 707185000631 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 707185000632 HIGH motif; other site 707185000633 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 707185000634 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 707185000635 active site 707185000636 KMSKS motif; other site 707185000637 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 707185000638 tRNA binding surface [nucleotide binding]; other site 707185000639 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00615 707185000640 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 707185000641 inhibitor-cofactor binding pocket; inhibition site 707185000642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707185000643 catalytic residue [active] 707185000644 Putative transcriptional regulator [Transcription]; Region: COG1678 707185000645 Uncharacterized conserved protein [Function unknown]; Region: COG1259 707185000646 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 707185000647 tetramer (dimer of dimers) interface [polypeptide binding]; other site 707185000648 active site 707185000649 dimer interface [polypeptide binding]; other site 707185000650 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 707185000651 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 707185000652 putative active site; other site 707185000653 catalytic residue [active] 707185000654 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 707185000655 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 707185000656 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 707185000657 Ligand Binding Site [chemical binding]; other site 707185000658 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 707185000659 prenyltransferase; Reviewed; Region: ubiA; PRK12876 707185000660 UbiA prenyltransferase family; Region: UbiA; pfam01040 707185000661 aromatic acid decarboxylase; Validated; Region: PRK05920 707185000662 Flavoprotein; Region: Flavoprotein; pfam02441 707185000663 Uncharacterized conserved protein [Function unknown]; Region: COG1284 707185000664 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 707185000665 IncA protein; Region: IncA; pfam04156 707185000666 IncA protein; Region: IncA; pfam04156 707185000667 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 707185000668 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 707185000669 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 707185000670 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 707185000671 Na2 binding site [ion binding]; other site 707185000672 putative substrate binding site 1 [chemical binding]; other site 707185000673 Na binding site 1 [ion binding]; other site 707185000674 putative substrate binding site 2 [chemical binding]; other site 707185000675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707185000676 putative substrate translocation pore; other site 707185000677 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 707185000678 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 707185000679 ligand binding site [chemical binding]; other site 707185000680 flexible hinge region; other site 707185000681 acyl carrier protein; Provisional; Region: acpP; PRK00982 707185000682 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 707185000683 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 707185000684 NAD(P) binding site [chemical binding]; other site 707185000685 homotetramer interface [polypeptide binding]; other site 707185000686 homodimer interface [polypeptide binding]; other site 707185000687 active site 707185000688 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 707185000689 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 707185000690 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 707185000691 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 707185000692 dimer interface [polypeptide binding]; other site 707185000693 active site 707185000694 CoA binding pocket [chemical binding]; other site 707185000695 recombination protein RecR; Region: recR; TIGR00615 707185000696 RecR protein; Region: RecR; pfam02132 707185000697 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 707185000698 putative active site [active] 707185000699 putative metal-binding site [ion binding]; other site 707185000700 tetramer interface [polypeptide binding]; other site 707185000701 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 707185000702 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 707185000703 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 707185000704 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 707185000705 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 707185000706 Surface antigen; Region: Bac_surface_Ag; pfam01103 707185000707 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 707185000708 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 707185000709 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 707185000710 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 707185000711 trimer interface [polypeptide binding]; other site 707185000712 active site 707185000713 UDP-GlcNAc binding site [chemical binding]; other site 707185000714 lipid binding site [chemical binding]; lipid-binding site 707185000715 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 707185000716 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 707185000717 tetramer interface [polypeptide binding]; other site 707185000718 TPP-binding site [chemical binding]; other site 707185000719 heterodimer interface [polypeptide binding]; other site 707185000720 phosphorylation loop region [posttranslational modification] 707185000721 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 707185000722 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 707185000723 alpha subunit interface [polypeptide binding]; other site 707185000724 TPP binding site [chemical binding]; other site 707185000725 heterodimer interface [polypeptide binding]; other site 707185000726 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 707185000727 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 707185000728 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 707185000729 E3 interaction surface; other site 707185000730 lipoyl attachment site [posttranslational modification]; other site 707185000731 e3 binding domain; Region: E3_binding; pfam02817 707185000732 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 707185000733 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 707185000734 homodimer interface [polypeptide binding]; other site 707185000735 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 707185000736 active site pocket [active] 707185000737 chromosomal replication initiation protein; Provisional; Region: PRK12422 707185000738 DnaA N-terminal domain; Region: DnaA_N; pfam11638 707185000739 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707185000740 Walker A motif; other site 707185000741 ATP binding site [chemical binding]; other site 707185000742 Walker B motif; other site 707185000743 arginine finger; other site 707185000744 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 707185000745 DnaA box-binding interface [nucleotide binding]; other site 707185000746 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 707185000747 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 707185000748 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 707185000749 CAAX protease self-immunity; Region: Abi; pfam02517 707185000750 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 707185000751 homodimer interface [polypeptide binding]; other site 707185000752 metal binding site [ion binding]; metal-binding site 707185000753 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 707185000754 Domain of unknown function DUF21; Region: DUF21; pfam01595 707185000755 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 707185000756 Transporter associated domain; Region: CorC_HlyC; smart01091 707185000757 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 707185000758 Domain of unknown function DUF21; Region: DUF21; pfam01595 707185000759 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 707185000760 Transporter associated domain; Region: CorC_HlyC; smart01091 707185000761 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 707185000762 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 707185000763 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 707185000764 catalytic residue [active] 707185000765 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 707185000766 Protein phosphatase 2C; Region: PP2C; pfam00481 707185000767 active site 707185000768 Uncharacterized conserved protein [Function unknown]; Region: COG5465 707185000769 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 707185000770 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 707185000771 active site 707185000772 catalytic site [active] 707185000773 substrate binding site [chemical binding]; other site 707185000774 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 707185000775 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 707185000776 nucleosidase; Provisional; Region: PRK05634 707185000777 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 707185000778 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 707185000779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707185000780 Walker A/P-loop; other site 707185000781 ATP binding site [chemical binding]; other site 707185000782 Q-loop/lid; other site 707185000783 ABC transporter signature motif; other site 707185000784 Walker B; other site 707185000785 D-loop; other site 707185000786 H-loop/switch region; other site 707185000787 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 707185000788 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 707185000789 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 707185000790 IHF - DNA interface [nucleotide binding]; other site 707185000791 IHF dimer interface [polypeptide binding]; other site 707185000792 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 707185000793 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 707185000794 active site 707185000795 metal binding site [ion binding]; metal-binding site 707185000796 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 707185000797 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 707185000798 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 707185000799 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 707185000800 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 707185000801 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 707185000802 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 707185000803 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 707185000804 MraW methylase family; Region: Methyltransf_5; pfam01795 707185000805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 707185000806 TPR motif; other site 707185000807 binding surface 707185000808 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 707185000809 DnaA N-terminal domain; Region: DnaA_N; pfam11638 707185000810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707185000811 Walker A motif; other site 707185000812 ATP binding site [chemical binding]; other site 707185000813 Walker B motif; other site 707185000814 arginine finger; other site 707185000815 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 707185000816 DnaA box-binding interface [nucleotide binding]; other site 707185000817 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 707185000818 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 707185000819 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 707185000820 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 707185000821 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 707185000822 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 707185000823 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 707185000824 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 707185000825 lipoyl attachment site [posttranslational modification]; other site 707185000826 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 707185000827 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 707185000828 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 707185000829 putative active site [active] 707185000830 catalytic site [active] 707185000831 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 707185000832 putative active site [active] 707185000833 catalytic site [active] 707185000834 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 707185000835 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 707185000836 Clp amino terminal domain; Region: Clp_N; pfam02861 707185000837 Clp amino terminal domain; Region: Clp_N; pfam02861 707185000838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707185000839 Walker A motif; other site 707185000840 ATP binding site [chemical binding]; other site 707185000841 Walker B motif; other site 707185000842 arginine finger; other site 707185000843 UvrB/uvrC motif; Region: UVR; pfam02151 707185000844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707185000845 Walker A motif; other site 707185000846 ATP binding site [chemical binding]; other site 707185000847 Walker B motif; other site 707185000848 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 707185000849 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 707185000850 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 707185000851 Ligand Binding Site [chemical binding]; other site 707185000852 Helix-turn-helix domain; Region: HTH_17; pfam12728 707185000853 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 707185000854 active site 707185000855 phosphorylation site [posttranslational modification] 707185000856 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 707185000857 active site 707185000858 phosphorylation site [posttranslational modification] 707185000859 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 707185000860 trimer interface [polypeptide binding]; other site 707185000861 active site 707185000862 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 707185000863 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 707185000864 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 707185000865 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 707185000866 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 707185000867 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 707185000868 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 707185000869 active site 707185000870 substrate binding site [chemical binding]; other site 707185000871 metal binding site [ion binding]; metal-binding site 707185000872 ribonuclease III; Reviewed; Region: rnc; PRK00102 707185000873 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 707185000874 dimerization interface [polypeptide binding]; other site 707185000875 active site 707185000876 metal binding site [ion binding]; metal-binding site 707185000877 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 707185000878 dsRNA binding site [nucleotide binding]; other site 707185000879 DNA repair protein RadA; Provisional; Region: PRK11823 707185000880 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 707185000881 Walker A motif/ATP binding site; other site 707185000882 ATP binding site [chemical binding]; other site 707185000883 Walker B motif; other site 707185000884 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 707185000885 porphobilinogen deaminase; Provisional; Region: PRK01066 707185000886 Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379 707185000887 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 707185000888 Catalytic domain of Protein Kinases; Region: PKc; cd00180 707185000889 active site 707185000890 ATP binding site [chemical binding]; other site 707185000891 substrate binding site [chemical binding]; other site 707185000892 activation loop (A-loop); other site 707185000893 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 707185000894 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 707185000895 HIGH motif; other site 707185000896 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 707185000897 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 707185000898 active site 707185000899 KMSKS motif; other site 707185000900 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 707185000901 tRNA binding surface [nucleotide binding]; other site 707185000902 anticodon binding site; other site 707185000903 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 707185000904 V-type ATP synthase subunit K; Provisional; Region: PRK09621 707185000905 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 707185000906 V-type ATP synthase subunit I; Validated; Region: PRK05771 707185000907 Protein of unknown function (DUF1319); Region: DUF1319; pfam07028 707185000908 V-type ATP synthase subunit D; Provisional; Region: PRK02195 707185000909 V-type ATP synthase subunit B; Provisional; Region: PRK02118 707185000910 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 707185000911 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 707185000912 Walker A motif homologous position; other site 707185000913 Walker B motif; other site 707185000914 V-type ATP synthase subunit A; Provisional; Region: PRK04192 707185000915 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 707185000916 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 707185000917 Walker A motif/ATP binding site; other site 707185000918 Walker B motif; other site 707185000919 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 707185000920 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 707185000921 V-type ATP synthase subunit E; Provisional; Region: PRK01005 707185000922 V-type ATP synthase subunit E; Provisional; Region: PRK01558 707185000923 transaldolase-like protein; Provisional; Region: PTZ00411 707185000924 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 707185000925 active site 707185000926 dimer interface [polypeptide binding]; other site 707185000927 catalytic residue [active] 707185000928 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 707185000929 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 707185000930 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 707185000931 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 707185000932 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 707185000933 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 707185000934 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 707185000935 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 707185000936 DNA binding site [nucleotide binding] 707185000937 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 707185000938 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 707185000939 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 707185000940 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 707185000941 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 707185000942 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 707185000943 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 707185000944 RPB12 interaction site [polypeptide binding]; other site 707185000945 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 707185000946 RPB3 interaction site [polypeptide binding]; other site 707185000947 RPB1 interaction site [polypeptide binding]; other site 707185000948 RPB11 interaction site [polypeptide binding]; other site 707185000949 RPB10 interaction site [polypeptide binding]; other site 707185000950 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 707185000951 L11 interface [polypeptide binding]; other site 707185000952 putative EF-Tu interaction site [polypeptide binding]; other site 707185000953 putative EF-G interaction site [polypeptide binding]; other site 707185000954 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 707185000955 23S rRNA interface [nucleotide binding]; other site 707185000956 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 707185000957 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 707185000958 mRNA/rRNA interface [nucleotide binding]; other site 707185000959 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 707185000960 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 707185000961 putative thiostrepton binding site; other site 707185000962 23S rRNA interface [nucleotide binding]; other site 707185000963 L7/L12 interface [polypeptide binding]; other site 707185000964 L25 interface [polypeptide binding]; other site 707185000965 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 707185000966 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 707185000967 putative homodimer interface [polypeptide binding]; other site 707185000968 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 707185000969 heterodimer interface [polypeptide binding]; other site 707185000970 homodimer interface [polypeptide binding]; other site 707185000971 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 707185000972 elongation factor Tu; Reviewed; Region: PRK12735 707185000973 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 707185000974 G1 box; other site 707185000975 GEF interaction site [polypeptide binding]; other site 707185000976 GTP/Mg2+ binding site [chemical binding]; other site 707185000977 Switch I region; other site 707185000978 G2 box; other site 707185000979 G3 box; other site 707185000980 Switch II region; other site 707185000981 G4 box; other site 707185000982 G5 box; other site 707185000983 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 707185000984 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 707185000985 Antibiotic Binding Site [chemical binding]; other site 707185000986 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 707185000987 rRNA binding site [nucleotide binding]; other site 707185000988 predicted 30S ribosome binding site; other site 707185000989 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 707185000990 Protein of unknown function (DUF687); Region: DUF687; pfam05095 707185000991 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 707185000992 active site 707185000993 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 707185000994 triosephosphate isomerase; Provisional; Region: PRK14565 707185000995 substrate binding site [chemical binding]; other site 707185000996 dimer interface [polypeptide binding]; other site 707185000997 catalytic triad [active] 707185000998 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 707185000999 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 707185001000 generic binding surface II; other site 707185001001 generic binding surface I; other site 707185001002 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 707185001003 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 707185001004 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 707185001005 TPP-binding site [chemical binding]; other site 707185001006 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 707185001007 PYR/PP interface [polypeptide binding]; other site 707185001008 dimer interface [polypeptide binding]; other site 707185001009 TPP binding site [chemical binding]; other site 707185001010 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 707185001011 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 707185001012 pyruvate kinase; Region: pyruv_kin; TIGR01064 707185001013 domain interfaces; other site 707185001014 active site 707185001015 excinuclease ABC subunit A; Provisional; Region: PRK00635 707185001016 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 707185001017 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 707185001018 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 707185001019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707185001020 Walker A/P-loop; other site 707185001021 ATP binding site [chemical binding]; other site 707185001022 Q-loop/lid; other site 707185001023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707185001024 ABC transporter signature motif; other site 707185001025 Walker B; other site 707185001026 D-loop; other site 707185001027 H-loop/switch region; other site 707185001028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707185001029 Walker A/P-loop; other site 707185001030 ATP binding site [chemical binding]; other site 707185001031 Q-loop/lid; other site 707185001032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707185001033 Q-loop/lid; other site 707185001034 ABC transporter signature motif; other site 707185001035 Walker B; other site 707185001036 D-loop; other site 707185001037 H-loop/switch region; other site 707185001038 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 707185001039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707185001040 Walker A motif; other site 707185001041 ATP binding site [chemical binding]; other site 707185001042 Walker B motif; other site 707185001043 arginine finger; other site 707185001044 hypothetical protein; Validated; Region: PRK00153 707185001045 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 707185001046 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 707185001047 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 707185001048 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 707185001049 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 707185001050 dimerization domain swap beta strand [polypeptide binding]; other site 707185001051 regulatory protein interface [polypeptide binding]; other site 707185001052 active site 707185001053 regulatory phosphorylation site [posttranslational modification]; other site 707185001054 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 707185001055 Competence protein; Region: Competence; pfam03772 707185001056 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 707185001057 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 707185001058 tetramer interface [polypeptide binding]; other site 707185001059 TPP-binding site [chemical binding]; other site 707185001060 heterodimer interface [polypeptide binding]; other site 707185001061 phosphorylation loop region [posttranslational modification] 707185001062 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 707185001063 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 707185001064 alpha subunit interface [polypeptide binding]; other site 707185001065 TPP binding site [chemical binding]; other site 707185001066 heterodimer interface [polypeptide binding]; other site 707185001067 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 707185001068 chaperone protein DnaJ; Provisional; Region: PRK14284 707185001069 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 707185001070 HSP70 interaction site [polypeptide binding]; other site 707185001071 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 707185001072 Zn binding sites [ion binding]; other site 707185001073 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 707185001074 dimer interface [polypeptide binding]; other site 707185001075 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 707185001076 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 707185001077 Glycoprotease family; Region: Peptidase_M22; pfam00814 707185001078 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 707185001079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707185001080 Walker A motif; other site 707185001081 ATP binding site [chemical binding]; other site 707185001082 Walker B motif; other site 707185001083 arginine finger; other site 707185001084 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 707185001085 ribonuclease Z; Region: RNase_Z; TIGR02651 707185001086 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 707185001087 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 707185001088 active site 707185001089 Int/Topo IB signature motif; other site 707185001090 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 707185001091 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 707185001092 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 707185001093 ABC transporter; Region: ABC_tran_2; pfam12848 707185001094 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 707185001095 Maf-like protein; Region: Maf; pfam02545 707185001096 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 707185001097 active site 707185001098 dimer interface [polypeptide binding]; other site 707185001099 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 707185001100 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 707185001101 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 707185001102 active site 707185001103 catalytic residues [active] 707185001104 metal binding site [ion binding]; metal-binding site 707185001105 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 707185001106 dimethyladenosine transferase; Region: ksgA; TIGR00755 707185001107 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 707185001108 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 707185001109 catalytic residues [active] 707185001110 potential protein location (hypothetical protein G9768_01835 [Chlamydia trachomatis G/9768]) that overlaps RNA (tRNA-S) 707185001111 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 707185001112 dihydrodipicolinate synthase; Region: dapA; TIGR00674 707185001113 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 707185001114 inhibitor site; inhibition site 707185001115 active site 707185001116 dimer interface [polypeptide binding]; other site 707185001117 catalytic residue [active] 707185001118 aspartate kinase; Provisional; Region: PRK05925 707185001119 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 707185001120 putative catalytic residues [active] 707185001121 nucleotide binding site [chemical binding]; other site 707185001122 aspartate binding site [chemical binding]; other site 707185001123 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 707185001124 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 707185001125 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 707185001126 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 707185001127 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 707185001128 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 707185001129 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 707185001130 hinge; other site 707185001131 active site 707185001132 shikimate kinase; Provisional; Region: PRK00625 707185001133 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 707185001134 ADP binding site [chemical binding]; other site 707185001135 magnesium binding site [ion binding]; other site 707185001136 putative shikimate binding site; other site 707185001137 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 707185001138 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 707185001139 Tetramer interface [polypeptide binding]; other site 707185001140 active site 707185001141 FMN-binding site [chemical binding]; other site 707185001142 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 707185001143 active site 707185001144 dimer interface [polypeptide binding]; other site 707185001145 metal binding site [ion binding]; metal-binding site 707185001146 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 707185001147 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 707185001148 active site 707185001149 catalytic residue [active] 707185001150 dimer interface [polypeptide binding]; other site 707185001151 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 707185001152 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 707185001153 shikimate binding site; other site 707185001154 NAD(P) binding site [chemical binding]; other site 707185001155 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 707185001156 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 707185001157 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 707185001158 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 707185001159 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 707185001160 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 707185001161 malate dehydrogenase; Provisional; Region: PRK05442 707185001162 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 707185001163 NAD(P) binding site [chemical binding]; other site 707185001164 dimer interface [polypeptide binding]; other site 707185001165 malate binding site [chemical binding]; other site 707185001166 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 707185001167 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 707185001168 active site 707185001169 dimer interface [polypeptide binding]; other site 707185001170 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 707185001171 dimer interface [polypeptide binding]; other site 707185001172 active site 707185001173 GTPases [General function prediction only]; Region: HflX; COG2262 707185001174 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 707185001175 HflX GTPase family; Region: HflX; cd01878 707185001176 G1 box; other site 707185001177 GTP/Mg2+ binding site [chemical binding]; other site 707185001178 Switch I region; other site 707185001179 G2 box; other site 707185001180 G3 box; other site 707185001181 Switch II region; other site 707185001182 G4 box; other site 707185001183 G5 box; other site 707185001184 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 707185001185 putative hydrolase; Provisional; Region: PRK02113 707185001186 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 707185001187 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 707185001188 substrate binding pocket [chemical binding]; other site 707185001189 membrane-bound complex binding site; other site 707185001190 hinge residues; other site 707185001191 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 707185001192 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 707185001193 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 707185001194 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 707185001195 nucleotide binding site/active site [active] 707185001196 Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286 707185001197 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 707185001198 hypothetical protein; Validated; Region: PRK00647 707185001199 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 707185001200 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 707185001201 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 707185001202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707185001203 homodimer interface [polypeptide binding]; other site 707185001204 catalytic residue [active] 707185001205 ABC transporter substrate binding protein; Region: ABC_sub_bind; pfam04392 707185001206 prolyl-tRNA synthetase; Provisional; Region: PRK09194 707185001207 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 707185001208 dimer interface [polypeptide binding]; other site 707185001209 motif 1; other site 707185001210 active site 707185001211 motif 2; other site 707185001212 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 707185001213 putative deacylase active site [active] 707185001214 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 707185001215 active site 707185001216 motif 3; other site 707185001217 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 707185001218 anticodon binding site; other site 707185001219 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 707185001220 GrpE; Region: GrpE; pfam01025 707185001221 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 707185001222 dimer interface [polypeptide binding]; other site 707185001223 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 707185001224 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 707185001225 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 707185001226 nucleotide binding site [chemical binding]; other site 707185001227 NEF interaction site [polypeptide binding]; other site 707185001228 SBD interface [polypeptide binding]; other site 707185001229 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 707185001230 Exoribonuclease R [Transcription]; Region: VacB; COG0557 707185001231 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 707185001232 RNB domain; Region: RNB; pfam00773 707185001233 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 707185001234 Putative zinc ribbon domain; Region: DUF164; pfam02591 707185001235 KpsF/GutQ family protein; Region: kpsF; TIGR00393 707185001236 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 707185001237 putative active site [active] 707185001238 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 707185001239 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 707185001240 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 707185001241 E3 interaction surface; other site 707185001242 lipoyl attachment site [posttranslational modification]; other site 707185001243 e3 binding domain; Region: E3_binding; pfam02817 707185001244 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 707185001245 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 707185001246 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 707185001247 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 707185001248 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 707185001249 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 707185001250 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 707185001251 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 707185001252 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 707185001253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707185001254 S-adenosylmethionine binding site [chemical binding]; other site 707185001255 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 707185001256 Lumazine binding domain; Region: Lum_binding; pfam00677 707185001257 Lumazine binding domain; Region: Lum_binding; pfam00677 707185001258 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 707185001259 ATP cone domain; Region: ATP-cone; pfam03477 707185001260 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 707185001261 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 707185001262 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 707185001263 amino acid carrier protein; Region: agcS; TIGR00835 707185001264 poly(A) polymerase; Region: pcnB; TIGR01942 707185001265 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 707185001266 active site 707185001267 NTP binding site [chemical binding]; other site 707185001268 metal binding triad [ion binding]; metal-binding site 707185001269 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 707185001270 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 707185001271 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 707185001272 Predicted membrane protein [Function unknown]; Region: COG3952 707185001273 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 707185001274 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 707185001275 Autotransporter beta-domain; Region: Autotransporter; pfam03797 707185001276 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 707185001277 Autotransporter beta-domain; Region: Autotransporter; pfam03797 707185001278 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 707185001279 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 707185001280 Autotransporter beta-domain; Region: Autotransporter; pfam03797 707185001281 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 707185001282 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 707185001283 intersubunit interface [polypeptide binding]; other site 707185001284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 707185001285 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 707185001286 Walker A/P-loop; other site 707185001287 ATP binding site [chemical binding]; other site 707185001288 Q-loop/lid; other site 707185001289 ABC transporter signature motif; other site 707185001290 Walker B; other site 707185001291 D-loop; other site 707185001292 H-loop/switch region; other site 707185001293 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 707185001294 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 707185001295 ABC-ATPase subunit interface; other site 707185001296 dimer interface [polypeptide binding]; other site 707185001297 putative PBP binding regions; other site 707185001298 GTPase CgtA; Reviewed; Region: obgE; PRK12299 707185001299 GTP1/OBG; Region: GTP1_OBG; pfam01018 707185001300 Obg GTPase; Region: Obg; cd01898 707185001301 G1 box; other site 707185001302 GTP/Mg2+ binding site [chemical binding]; other site 707185001303 Switch I region; other site 707185001304 G2 box; other site 707185001305 G3 box; other site 707185001306 Switch II region; other site 707185001307 G4 box; other site 707185001308 G5 box; other site 707185001309 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 707185001310 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 707185001311 Uncharacterized conserved protein [Function unknown]; Region: COG2928 707185001312 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 707185001313 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 707185001314 FOG: CBS domain [General function prediction only]; Region: COG0517 707185001315 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 707185001316 Transporter associated domain; Region: CorC_HlyC; smart01091 707185001317 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 707185001318 anti sigma factor interaction site; other site 707185001319 regulatory phosphorylation site [posttranslational modification]; other site 707185001320 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 707185001321 hypothetical protein; Provisional; Region: PRK05926 707185001322 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 707185001323 FeS/SAM binding site; other site 707185001324 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 707185001325 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 707185001326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707185001327 S-adenosylmethionine binding site [chemical binding]; other site 707185001328 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 707185001329 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 707185001330 diaminopimelate epimerase; Region: DapF; TIGR00652 707185001331 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 707185001332 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 707185001333 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 707185001334 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 707185001335 oligomer interface [polypeptide binding]; other site 707185001336 active site residues [active] 707185001337 serine hydroxymethyltransferase; Provisional; Region: PRK13580 707185001338 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 707185001339 dimer interface [polypeptide binding]; other site 707185001340 active site 707185001341 glycine-pyridoxal phosphate binding site [chemical binding]; other site 707185001342 folate binding site [chemical binding]; other site 707185001343 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 707185001344 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 707185001345 active site 707185001346 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 707185001347 homotrimer interaction site [polypeptide binding]; other site 707185001348 zinc binding site [ion binding]; other site 707185001349 CDP-binding sites; other site 707185001350 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 707185001351 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 707185001352 FAD binding pocket [chemical binding]; other site 707185001353 conserved FAD binding motif [chemical binding]; other site 707185001354 phosphate binding motif [ion binding]; other site 707185001355 beta-alpha-beta structure motif; other site 707185001356 NAD binding pocket [chemical binding]; other site 707185001357 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 707185001358 elongation factor G; Reviewed; Region: PRK12739 707185001359 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 707185001360 G1 box; other site 707185001361 putative GEF interaction site [polypeptide binding]; other site 707185001362 GTP/Mg2+ binding site [chemical binding]; other site 707185001363 Switch I region; other site 707185001364 G2 box; other site 707185001365 G3 box; other site 707185001366 Switch II region; other site 707185001367 G4 box; other site 707185001368 G5 box; other site 707185001369 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 707185001370 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 707185001371 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 707185001372 30S ribosomal protein S7; Validated; Region: PRK05302 707185001373 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 707185001374 S17 interaction site [polypeptide binding]; other site 707185001375 S8 interaction site; other site 707185001376 16S rRNA interaction site [nucleotide binding]; other site 707185001377 streptomycin interaction site [chemical binding]; other site 707185001378 23S rRNA interaction site [nucleotide binding]; other site 707185001379 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 707185001380 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 707185001381 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 707185001382 protein binding site [polypeptide binding]; other site 707185001383 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 707185001384 Catalytic dyad [active] 707185001385 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 707185001386 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 707185001387 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 707185001388 Domain of unknown function DUF11; Region: DUF11; pfam01345 707185001389 Domain of unknown function DUF11; Region: DUF11; pfam01345 707185001390 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 707185001391 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 707185001392 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 707185001393 HIGH motif; other site 707185001394 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 707185001395 active site 707185001396 KMSKS motif; other site 707185001397 Helix-turn-helix domain; Region: HTH_17; pfam12728 707185001398 Helix-turn-helix domain; Region: HTH_17; cl17695 707185001399 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 707185001400 DHH family; Region: DHH; pfam01368 707185001401 DHHA1 domain; Region: DHHA1; pfam02272 707185001402 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 707185001403 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 707185001404 Protein export membrane protein; Region: SecD_SecF; pfam02355 707185001405 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 707185001406 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 707185001407 catalytic residue [active] 707185001408 putative FPP diphosphate binding site; other site 707185001409 putative FPP binding hydrophobic cleft; other site 707185001410 dimer interface [polypeptide binding]; other site 707185001411 putative IPP diphosphate binding site; other site 707185001412 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 707185001413 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 707185001414 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 707185001415 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 707185001416 CMP-binding site; other site 707185001417 The sites determining sugar specificity; other site 707185001418 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 707185001419 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 707185001420 putative acyl-acceptor binding pocket; other site 707185001421 arginine-tRNA ligase; Region: PLN02286 707185001422 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 707185001423 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 707185001424 active site 707185001425 HIGH motif; other site 707185001426 KMSK motif region; other site 707185001427 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 707185001428 tRNA binding surface [nucleotide binding]; other site 707185001429 anticodon binding site; other site 707185001430 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 707185001431 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 707185001432 hinge; other site 707185001433 active site 707185001434 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 707185001435 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 707185001436 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 707185001437 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 707185001438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 707185001439 Coenzyme A binding pocket [chemical binding]; other site 707185001440 PCRF domain; Region: PCRF; pfam03462 707185001441 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 707185001442 RF-1 domain; Region: RF-1; pfam00472 707185001443 SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531 707185001444 SWI complex, BAF60b domains; Region: SWIB; smart00151 707185001445 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 707185001446 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 707185001447 putative active site [active] 707185001448 putative metal binding site [ion binding]; other site 707185001449 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 707185001450 substrate binding site; other site 707185001451 dimer interface; other site 707185001452 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 707185001453 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 707185001454 dimerization interface 3.5A [polypeptide binding]; other site 707185001455 active site 707185001456 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 707185001457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 707185001458 active site 707185001459 motif I; other site 707185001460 motif II; other site 707185001461 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 707185001462 PAS domain; Region: PAS; smart00091 707185001463 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 707185001464 dimer interface [polypeptide binding]; other site 707185001465 phosphorylation site [posttranslational modification] 707185001466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 707185001467 ATP binding site [chemical binding]; other site 707185001468 Mg2+ binding site [ion binding]; other site 707185001469 G-X-G motif; other site 707185001470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 707185001471 Response regulator receiver domain; Region: Response_reg; pfam00072 707185001472 active site 707185001473 phosphorylation site [posttranslational modification] 707185001474 intermolecular recognition site; other site 707185001475 dimerization interface [polypeptide binding]; other site 707185001476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707185001477 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 707185001478 Walker A motif; other site 707185001479 ATP binding site [chemical binding]; other site 707185001480 Walker B motif; other site 707185001481 arginine finger; other site 707185001482 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 707185001483 Recombination protein O N terminal; Region: RecO_N; pfam11967 707185001484 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 707185001485 Recombination protein O C terminal; Region: RecO_C; pfam02565 707185001486 potential protein location (hypothetical protein G9768_02460 [Chlamydia trachomatis G/9768]) that overlaps RNA (tRNA-L) 707185001487 Uncharacterized conserved protein [Function unknown]; Region: COG1723 707185001488 hypothetical protein; Provisional; Region: PRK14377 707185001489 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 707185001490 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 707185001491 putative tRNA-binding site [nucleotide binding]; other site 707185001492 B3/4 domain; Region: B3_4; pfam03483 707185001493 tRNA synthetase B5 domain; Region: B5; smart00874 707185001494 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 707185001495 dimer interface [polypeptide binding]; other site 707185001496 motif 1; other site 707185001497 motif 3; other site 707185001498 motif 2; other site 707185001499 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 707185001500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 707185001501 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 707185001502 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 707185001503 DNA binding site [nucleotide binding] 707185001504 active site 707185001505 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 707185001506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707185001507 dimer interface [polypeptide binding]; other site 707185001508 conserved gate region; other site 707185001509 putative PBP binding loops; other site 707185001510 ABC-ATPase subunit interface; other site 707185001511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 707185001512 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 707185001513 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 707185001514 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 707185001515 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 707185001516 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 707185001517 putative active site [active] 707185001518 putative metal binding site [ion binding]; other site 707185001519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 707185001520 binding surface 707185001521 TPR motif; other site 707185001522 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 707185001523 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 707185001524 C-terminal domain interface [polypeptide binding]; other site 707185001525 active site 707185001526 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 707185001527 active site 707185001528 N-terminal domain interface [polypeptide binding]; other site 707185001529 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 707185001530 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 707185001531 substrate binding pocket [chemical binding]; other site 707185001532 membrane-bound complex binding site; other site 707185001533 hinge residues; other site 707185001534 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 707185001535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707185001536 S-adenosylmethionine binding site [chemical binding]; other site 707185001537 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 707185001538 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 707185001539 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 707185001540 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 707185001541 ligand binding site; other site 707185001542 oligomer interface; other site 707185001543 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 707185001544 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 707185001545 N-terminal domain interface [polypeptide binding]; other site 707185001546 sulfate 1 binding site; other site 707185001547 transcription termination factor Rho; Region: rho; TIGR00767 707185001548 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 707185001549 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 707185001550 RNA binding site [nucleotide binding]; other site 707185001551 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 707185001552 multimer interface [polypeptide binding]; other site 707185001553 Walker A motif; other site 707185001554 ATP binding site [chemical binding]; other site 707185001555 Walker B motif; other site 707185001556 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 707185001557 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 707185001558 CoA-binding site [chemical binding]; other site 707185001559 ATP-binding [chemical binding]; other site 707185001560 DNA polymerase I; Provisional; Region: PRK05755 707185001561 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 707185001562 active site 707185001563 metal binding site 1 [ion binding]; metal-binding site 707185001564 putative 5' ssDNA interaction site; other site 707185001565 metal binding site 3; metal-binding site 707185001566 metal binding site 2 [ion binding]; metal-binding site 707185001567 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 707185001568 putative DNA binding site [nucleotide binding]; other site 707185001569 putative metal binding site [ion binding]; other site 707185001570 3'-5' exonuclease; Region: 35EXOc; smart00474 707185001571 active site 707185001572 substrate binding site [chemical binding]; other site 707185001573 catalytic site [active] 707185001574 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 707185001575 active site 707185001576 DNA binding site [nucleotide binding] 707185001577 catalytic site [active] 707185001578 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 707185001579 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 707185001580 tandem repeat interface [polypeptide binding]; other site 707185001581 oligomer interface [polypeptide binding]; other site 707185001582 active site residues [active] 707185001583 TLC ATP/ADP transporter; Region: TLC; pfam03219 707185001584 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 707185001585 replicative DNA helicase; Provisional; Region: PRK06321 707185001586 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 707185001587 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 707185001588 Walker A motif; other site 707185001589 ATP binding site [chemical binding]; other site 707185001590 Walker B motif; other site 707185001591 DNA binding loops [nucleotide binding] 707185001592 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 707185001593 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 707185001594 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 707185001595 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 707185001596 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 707185001597 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 707185001598 active site 707185001599 multimer interface [polypeptide binding]; other site 707185001600 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 707185001601 RuvA N terminal domain; Region: RuvA_N; pfam01330 707185001602 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 707185001603 active site 707185001604 putative DNA-binding cleft [nucleotide binding]; other site 707185001605 dimer interface [polypeptide binding]; other site 707185001606 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 707185001607 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 707185001608 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 707185001609 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 707185001610 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 707185001611 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 707185001612 alphaNTD - beta interaction site [polypeptide binding]; other site 707185001613 alphaNTD homodimer interface [polypeptide binding]; other site 707185001614 alphaNTD - beta' interaction site [polypeptide binding]; other site 707185001615 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 707185001616 30S ribosomal protein S11; Validated; Region: PRK05309 707185001617 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 707185001618 30S ribosomal protein S13; Region: bact_S13; TIGR03631 707185001619 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 707185001620 SecY translocase; Region: SecY; pfam00344 707185001621 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 707185001622 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 707185001623 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 707185001624 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 707185001625 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 707185001626 5S rRNA interface [nucleotide binding]; other site 707185001627 23S rRNA interface [nucleotide binding]; other site 707185001628 L5 interface [polypeptide binding]; other site 707185001629 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 707185001630 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 707185001631 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 707185001632 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 707185001633 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 707185001634 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 707185001635 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 707185001636 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 707185001637 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 707185001638 RNA binding site [nucleotide binding]; other site 707185001639 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 707185001640 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 707185001641 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 707185001642 23S rRNA interface [nucleotide binding]; other site 707185001643 putative translocon interaction site; other site 707185001644 signal recognition particle (SRP54) interaction site; other site 707185001645 L23 interface [polypeptide binding]; other site 707185001646 trigger factor interaction site; other site 707185001647 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 707185001648 23S rRNA interface [nucleotide binding]; other site 707185001649 5S rRNA interface [nucleotide binding]; other site 707185001650 putative antibiotic binding site [chemical binding]; other site 707185001651 L25 interface [polypeptide binding]; other site 707185001652 L27 interface [polypeptide binding]; other site 707185001653 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 707185001654 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 707185001655 G-X-X-G motif; other site 707185001656 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 707185001657 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 707185001658 putative translocon binding site; other site 707185001659 protein-rRNA interface [nucleotide binding]; other site 707185001660 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 707185001661 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 707185001662 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 707185001663 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 707185001664 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 707185001665 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 707185001666 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 707185001667 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 707185001668 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 707185001669 putative active site [active] 707185001670 substrate binding site [chemical binding]; other site 707185001671 putative cosubstrate binding site; other site 707185001672 catalytic site [active] 707185001673 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 707185001674 substrate binding site [chemical binding]; other site 707185001675 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 707185001676 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 707185001677 active site 707185001678 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 707185001679 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 707185001680 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 707185001681 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 707185001682 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 707185001683 putative active site [active] 707185001684 catalytic triad [active] 707185001685 putative dimer interface [polypeptide binding]; other site 707185001686 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 707185001687 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 707185001688 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 707185001689 active site 707185001690 catalytic site [active] 707185001691 substrate binding site [chemical binding]; other site 707185001692 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 707185001693 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 707185001694 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 707185001695 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 707185001696 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 707185001697 catalytic residues [active] 707185001698 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 707185001699 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 707185001700 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 707185001701 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 707185001702 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 707185001703 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 707185001704 dimer interface [polypeptide binding]; other site 707185001705 anticodon binding site; other site 707185001706 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 707185001707 homodimer interface [polypeptide binding]; other site 707185001708 motif 1; other site 707185001709 active site 707185001710 motif 2; other site 707185001711 GAD domain; Region: GAD; pfam02938 707185001712 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 707185001713 active site 707185001714 motif 3; other site 707185001715 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 707185001716 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 707185001717 dimer interface [polypeptide binding]; other site 707185001718 motif 1; other site 707185001719 active site 707185001720 motif 2; other site 707185001721 motif 3; other site 707185001722 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 707185001723 anticodon binding site; other site 707185001724 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 707185001725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707185001726 putative substrate translocation pore; other site 707185001727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707185001728 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 707185001729 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 707185001730 active site 707185001731 PHP Thumb interface [polypeptide binding]; other site 707185001732 metal binding site [ion binding]; metal-binding site 707185001733 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 707185001734 generic binding surface I; other site 707185001735 generic binding surface II; other site 707185001736 TPR repeat; Region: TPR_11; pfam13414 707185001737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 707185001738 binding surface 707185001739 TPR motif; other site 707185001740 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 707185001741 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 707185001742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 707185001743 Mg2+ binding site [ion binding]; other site 707185001744 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 707185001745 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 707185001746 potential frameshift: common BLAST hit: gi|237804904|ref|YP_002889058.1| putative methyltransferase 707185001747 branched-chain amino acid uptake carrier; Region: livcs; TIGR00796 707185001748 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 707185001749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 707185001750 ATP binding site [chemical binding]; other site 707185001751 putative Mg++ binding site [ion binding]; other site 707185001752 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 707185001753 nucleotide binding region [chemical binding]; other site 707185001754 ATP-binding site [chemical binding]; other site 707185001755 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 707185001756 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 707185001757 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 707185001758 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 707185001759 lipoate synthase; Region: lipA; TIGR00510 707185001760 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 707185001761 FeS/SAM binding site; other site 707185001762 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 707185001763 type III secretion system protein; Validated; Region: PRK06328 707185001764 Flagellar assembly protein FliH; Region: FliH; pfam02108 707185001765 type III secretion system protein; Reviewed; Region: PRK09617 707185001766 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 707185001767 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 707185001768 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 707185001769 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 707185001770 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 707185001771 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 707185001772 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 707185001773 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 707185001774 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 707185001775 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 707185001776 Walker A motif; other site 707185001777 ATP binding site [chemical binding]; other site 707185001778 Walker B motif; other site 707185001779 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 707185001780 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 707185001781 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 707185001782 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 707185001783 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 707185001784 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 707185001785 active site 707185001786 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 707185001787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 707185001788 ATP binding site [chemical binding]; other site 707185001789 Mg2+ binding site [ion binding]; other site 707185001790 G-X-G motif; other site 707185001791 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 707185001792 ATP binding site [chemical binding]; other site 707185001793 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 707185001794 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 707185001795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 707185001796 binding surface 707185001797 TPR motif; other site 707185001798 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 707185001799 EamA-like transporter family; Region: EamA; pfam00892 707185001800 EamA-like transporter family; Region: EamA; pfam00892 707185001801 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 707185001802 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cd01616 707185001803 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 707185001804 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 707185001805 active site 707185001806 dimer interface [polypeptide binding]; other site 707185001807 motif 1; other site 707185001808 motif 2; other site 707185001809 motif 3; other site 707185001810 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 707185001811 anticodon binding site; other site 707185001812 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 707185001813 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 707185001814 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 707185001815 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 707185001816 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 707185001817 active site 707185001818 HIGH motif; other site 707185001819 dimer interface [polypeptide binding]; other site 707185001820 KMSKS motif; other site 707185001821 excinuclease ABC subunit B; Provisional; Region: PRK05298 707185001822 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 707185001823 ATP binding site [chemical binding]; other site 707185001824 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 707185001825 nucleotide binding region [chemical binding]; other site 707185001826 ATP-binding site [chemical binding]; other site 707185001827 Ultra-violet resistance protein B; Region: UvrB; pfam12344 707185001828 enolase; Provisional; Region: eno; PRK00077 707185001829 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 707185001830 dimer interface [polypeptide binding]; other site 707185001831 metal binding site [ion binding]; metal-binding site 707185001832 substrate binding pocket [chemical binding]; other site 707185001833 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 707185001834 HAMP domain; Region: HAMP; pfam00672 707185001835 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 707185001836 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 707185001837 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 707185001838 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 707185001839 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 707185001840 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 707185001841 L-aspartate oxidase; Provisional; Region: PRK06175 707185001842 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 707185001843 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 707185001844 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 707185001845 proximal heme binding site [chemical binding]; other site 707185001846 Iron-sulfur protein interface; other site 707185001847 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 707185001848 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 707185001849 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 707185001850 active site 707185001851 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 707185001852 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 707185001853 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 707185001854 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 707185001855 DsbD alpha interface [polypeptide binding]; other site 707185001856 catalytic residues [active] 707185001857 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 707185001858 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 707185001859 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 707185001860 translocation protein TolB; Provisional; Region: tolB; PRK01029 707185001861 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 707185001862 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 707185001863 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 707185001864 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 707185001865 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 707185001866 ligand binding site [chemical binding]; other site 707185001867 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 707185001868 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 707185001869 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 707185001870 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 707185001871 dimer interface [polypeptide binding]; other site 707185001872 decamer (pentamer of dimers) interface [polypeptide binding]; other site 707185001873 catalytic triad [active] 707185001874 peroxidatic and resolving cysteines [active] 707185001875 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 707185001876 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 707185001877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 707185001878 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 707185001879 active site 707185001880 dimerization interface [polypeptide binding]; other site 707185001881 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 707185001882 ligand binding site [chemical binding]; other site 707185001883 active site 707185001884 UGI interface [polypeptide binding]; other site 707185001885 catalytic site [active] 707185001886 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 707185001887 Part of AAA domain; Region: AAA_19; pfam13245 707185001888 Family description; Region: UvrD_C_2; pfam13538 707185001889 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 707185001890 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 707185001891 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 707185001892 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 707185001893 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 707185001894 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 707185001895 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 707185001896 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 707185001897 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 707185001898 folate binding site [chemical binding]; other site 707185001899 NADP+ binding site [chemical binding]; other site 707185001900 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 707185001901 catalytic center binding site [active] 707185001902 ATP binding site [chemical binding]; other site 707185001903 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 707185001904 dihydropteroate synthase; Region: DHPS; TIGR01496 707185001905 substrate binding pocket [chemical binding]; other site 707185001906 dimer interface [polypeptide binding]; other site 707185001907 inhibitor binding site; inhibition site 707185001908 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 707185001909 homooctamer interface [polypeptide binding]; other site 707185001910 active site 707185001911 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 707185001912 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 707185001913 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 707185001914 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 707185001915 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 707185001916 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 707185001917 DNA binding residues [nucleotide binding] 707185001918 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 707185001919 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 707185001920 Effector from type III secretion system; Region: Effector_1; pfam04518 707185001921 Effector from type III secretion system; Region: Effector_1; pfam04518 707185001922 Effector from type III secretion system; Region: Effector_1; pfam04518 707185001923 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 707185001924 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 707185001925 MviN-like protein; Region: MVIN; pfam03023 707185001926 endonuclease IV; Provisional; Region: PRK01060 707185001927 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 707185001928 AP (apurinic/apyrimidinic) site pocket; other site 707185001929 DNA interaction; other site 707185001930 Metal-binding active site; metal-binding site 707185001931 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 707185001932 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 707185001933 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 707185001934 RNA binding surface [nucleotide binding]; other site 707185001935 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 707185001936 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 707185001937 active site residue [active] 707185001938 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 707185001939 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 707185001940 substrate binding pocket [chemical binding]; other site 707185001941 chain length determination region; other site 707185001942 substrate-Mg2+ binding site; other site 707185001943 catalytic residues [active] 707185001944 aspartate-rich region 1; other site 707185001945 active site lid residues [active] 707185001946 aspartate-rich region 2; other site 707185001947 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 707185001948 putative trimer interface [polypeptide binding]; other site 707185001949 putative CoA binding site [chemical binding]; other site 707185001950 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 707185001951 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 707185001952 DNA binding site [nucleotide binding] 707185001953 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 707185001954 Thymidylate synthase complementing protein; Region: Thy1; cl03630 707185001955 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 707185001956 dimer interface [polypeptide binding]; other site 707185001957 active site 707185001958 aspartate-rich active site metal binding site; other site 707185001959 allosteric magnesium binding site [ion binding]; other site 707185001960 Schiff base residues; other site 707185001961 NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit; Region: nqrA; TIGR01936 707185001962 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 707185001963 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 707185001964 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 707185001965 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 707185001966 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 707185001967 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 707185001968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 707185001969 homodimer interface [polypeptide binding]; other site 707185001970 catalytic residue [active] 707185001971 rod shape-determining protein MreC; Provisional; Region: PRK14872 707185001972 rod shape-determining protein MreC; Region: MreC; pfam04085 707185001973 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 707185001974 Part of AAA domain; Region: AAA_19; pfam13245 707185001975 Family description; Region: UvrD_C_2; pfam13538 707185001976 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 707185001977 Major Facilitator Superfamily; Region: MFS_1; pfam07690 707185001978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 707185001979 putative substrate translocation pore; other site 707185001980 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 707185001981 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 707185001982 active site 707185001983 interdomain interaction site; other site 707185001984 putative metal-binding site [ion binding]; other site 707185001985 nucleotide binding site [chemical binding]; other site 707185001986 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 707185001987 domain I; other site 707185001988 DNA binding groove [nucleotide binding] 707185001989 phosphate binding site [ion binding]; other site 707185001990 domain II; other site 707185001991 domain III; other site 707185001992 nucleotide binding site [chemical binding]; other site 707185001993 catalytic site [active] 707185001994 domain IV; other site 707185001995 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 707185001996 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 707185001997 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 707185001998 SWI complex, BAF60b domains; Region: SWIB; smart00151 707185001999 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 707185002000 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 707185002001 FMN binding site [chemical binding]; other site 707185002002 active site 707185002003 catalytic residues [active] 707185002004 substrate binding site [chemical binding]; other site 707185002005 Predicted integral membrane protein [Function unknown]; Region: COG0762 707185002006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 707185002007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 707185002008 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 707185002009 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 707185002010 recombinase A; Provisional; Region: recA; PRK09354 707185002011 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 707185002012 hexamer interface [polypeptide binding]; other site 707185002013 Walker A motif; other site 707185002014 ATP binding site [chemical binding]; other site 707185002015 Walker B motif; other site 707185002016 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 707185002017 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 707185002018 AAA domain; Region: AAA_30; pfam13604 707185002019 Family description; Region: UvrD_C_2; pfam13538 707185002020 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 707185002021 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 707185002022 Walker A/P-loop; other site 707185002023 ATP binding site [chemical binding]; other site 707185002024 Q-loop/lid; other site 707185002025 ABC transporter signature motif; other site 707185002026 Walker B; other site 707185002027 D-loop; other site 707185002028 H-loop/switch region; other site 707185002029 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 707185002030 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 707185002031 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 707185002032 potential protein location (hypothetical protein G9768_03455 [Chlamydia trachomatis G/9768]) that overlaps RNA (tRNA-R) 707185002033 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 707185002034 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 707185002035 RNA binding surface [nucleotide binding]; other site 707185002036 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 707185002037 active site 707185002038 hypothetical protein; Provisional; Region: PRK01064 707185002039 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 707185002040 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 707185002041 DNA Topoisomerase IV; Region: TOP4c; smart00434 707185002042 CAP-like domain; other site 707185002043 active site 707185002044 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 707185002045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 707185002046 ATP binding site [chemical binding]; other site 707185002047 Mg2+ binding site [ion binding]; other site 707185002048 G-X-G motif; other site 707185002049 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 707185002050 ATP binding site [chemical binding]; other site 707185002051 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 707185002052 active site 707185002053 putative metal-binding site [ion binding]; other site 707185002054 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 707185002055 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 707185002056 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 707185002057 NAD(P) binding pocket [chemical binding]; other site 707185002058 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 707185002059 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 707185002060 phosphopeptide binding site; other site 707185002061 MARCKS family; Region: MARCKS; pfam02063 707185002062 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 707185002063 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 707185002064 phosphopeptide binding site; other site 707185002065 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 707185002066 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 707185002067 binding surface 707185002068 Tetratricopeptide repeat; Region: TPR_16; pfam13432 707185002069 TPR motif; other site 707185002070 type III secretion system ATPase; Provisional; Region: PRK06315 707185002071 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 707185002072 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 707185002073 Walker A motif/ATP binding site; other site 707185002074 Walker B motif; other site 707185002075 type III secretion system protein; Validated; Region: PRK05933 707185002076 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 707185002077 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 707185002078 Catalytic domain of Protein Kinases; Region: PKc; cd00180 707185002079 active site 707185002080 ATP binding site [chemical binding]; other site 707185002081 substrate binding site [chemical binding]; other site 707185002082 activation loop (A-loop); other site 707185002083 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 707185002084 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 707185002085 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 707185002086 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 707185002087 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 707185002088 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 707185002089 ADP binding site [chemical binding]; other site 707185002090 phosphagen binding site; other site 707185002091 substrate specificity loop; other site 707185002092 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 707185002093 UvrB/uvrC motif; Region: UVR; pfam02151 707185002094 ribosome recycling factor; Reviewed; Region: frr; PRK00083 707185002095 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 707185002096 hinge region; other site 707185002097 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 707185002098 putative nucleotide binding site [chemical binding]; other site 707185002099 uridine monophosphate binding site [chemical binding]; other site 707185002100 homohexameric interface [polypeptide binding]; other site 707185002101 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 707185002102 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 707185002103 Elongation factor TS; Region: EF_TS; pfam00889 707185002104 Elongation factor TS; Region: EF_TS; pfam00889 707185002105 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 707185002106 rRNA interaction site [nucleotide binding]; other site 707185002107 S8 interaction site; other site 707185002108 putative laminin-1 binding site; other site 707185002109 potential protein location (hypothetical protein G9768_03595 [Chlamydia trachomatis G/9768]) that overlaps RNA (tRNA-G) 707185002110 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 707185002111 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 707185002112 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 707185002113 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 707185002114 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 707185002115 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 707185002116 TPR motif; other site 707185002117 Tetratricopeptide repeat; Region: TPR_16; pfam13432 707185002118 binding surface 707185002119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 707185002120 binding surface 707185002121 TPR motif; other site 707185002122 TPR repeat; Region: TPR_11; pfam13414 707185002123 TPR repeat; Region: TPR_11; pfam13414 707185002124 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 707185002125 binding surface 707185002126 TPR motif; other site 707185002127 TPR repeat; Region: TPR_11; pfam13414 707185002128 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 707185002129 putative ABC transporter; Region: ycf24; CHL00085 707185002130 FeS assembly ATPase SufC; Region: sufC; TIGR01978 707185002131 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 707185002132 Walker A/P-loop; other site 707185002133 ATP binding site [chemical binding]; other site 707185002134 Q-loop/lid; other site 707185002135 ABC transporter signature motif; other site 707185002136 Walker B; other site 707185002137 D-loop; other site 707185002138 H-loop/switch region; other site 707185002139 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 707185002140 FeS assembly protein SufD; Region: sufD; TIGR01981 707185002141 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 707185002142 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 707185002143 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 707185002144 catalytic residue [active] 707185002145 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 707185002146 ParB-like nuclease domain; Region: ParBc; pfam02195 707185002147 KorB domain; Region: KorB; pfam08535 707185002148 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 707185002149 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 707185002150 Walker A/P-loop; other site 707185002151 ATP binding site [chemical binding]; other site 707185002152 Q-loop/lid; other site 707185002153 ABC transporter signature motif; other site 707185002154 Walker B; other site 707185002155 D-loop; other site 707185002156 H-loop/switch region; other site 707185002157 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 707185002158 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 707185002159 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 707185002160 Walker A/P-loop; other site 707185002161 ATP binding site [chemical binding]; other site 707185002162 Q-loop/lid; other site 707185002163 ABC transporter signature motif; other site 707185002164 Walker B; other site 707185002165 D-loop; other site 707185002166 H-loop/switch region; other site 707185002167 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 707185002168 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 707185002169 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 707185002170 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 707185002171 Phosphoglycerate kinase; Region: PGK; pfam00162 707185002172 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 707185002173 substrate binding site [chemical binding]; other site 707185002174 hinge regions; other site 707185002175 ADP binding site [chemical binding]; other site 707185002176 catalytic site [active] 707185002177 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 707185002178 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 707185002179 minor groove reading motif; other site 707185002180 helix-hairpin-helix signature motif; other site 707185002181 substrate binding pocket [chemical binding]; other site 707185002182 active site 707185002183 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 707185002184 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 707185002185 trmE is a tRNA modification GTPase; Region: trmE; cd04164 707185002186 G1 box; other site 707185002187 GTP/Mg2+ binding site [chemical binding]; other site 707185002188 Switch I region; other site 707185002189 G2 box; other site 707185002190 Switch II region; other site 707185002191 G3 box; other site 707185002192 G4 box; other site 707185002193 G5 box; other site 707185002194 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 707185002195 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 707185002196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 707185002197 binding surface 707185002198 TPR motif; other site 707185002199 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 707185002200 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 707185002201 ATP binding site [chemical binding]; other site 707185002202 putative Mg++ binding site [ion binding]; other site 707185002203 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 707185002204 Predicted GTPases [General function prediction only]; Region: COG1160 707185002205 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 707185002206 G1 box; other site 707185002207 GTP/Mg2+ binding site [chemical binding]; other site 707185002208 Switch I region; other site 707185002209 G2 box; other site 707185002210 Switch II region; other site 707185002211 G3 box; other site 707185002212 G4 box; other site 707185002213 G5 box; other site 707185002214 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 707185002215 G1 box; other site 707185002216 GTP/Mg2+ binding site [chemical binding]; other site 707185002217 Switch I region; other site 707185002218 G2 box; other site 707185002219 G3 box; other site 707185002220 Switch II region; other site 707185002221 G4 box; other site 707185002222 G5 box; other site 707185002223 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 707185002224 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 707185002225 active site 707185002226 NTP binding site [chemical binding]; other site 707185002227 metal binding triad [ion binding]; metal-binding site 707185002228 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 707185002229 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 707185002230 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 707185002231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707185002232 Walker A motif; other site 707185002233 ATP binding site [chemical binding]; other site 707185002234 Walker B motif; other site 707185002235 arginine finger; other site 707185002236 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 707185002237 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 707185002238 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 707185002239 oligomer interface [polypeptide binding]; other site 707185002240 active site residues [active] 707185002241 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 707185002242 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 707185002243 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 707185002244 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 707185002245 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 707185002246 ATP binding site [chemical binding]; other site 707185002247 putative Mg++ binding site [ion binding]; other site 707185002248 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 707185002249 nucleotide binding region [chemical binding]; other site 707185002250 ATP-binding site [chemical binding]; other site 707185002251 rod shape-determining protein MreB; Provisional; Region: PRK13927 707185002252 MreB and similar proteins; Region: MreB_like; cd10225 707185002253 nucleotide binding site [chemical binding]; other site 707185002254 Mg binding site [ion binding]; other site 707185002255 putative protofilament interaction site [polypeptide binding]; other site 707185002256 RodZ interaction site [polypeptide binding]; other site 707185002257 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 707185002258 active site 707185002259 substrate-binding site [chemical binding]; other site 707185002260 metal-binding site [ion binding] 707185002261 GTP binding site [chemical binding]; other site 707185002262 Effector from type III secretion system; Region: Effector_1; pfam04518 707185002263 Effector from type III secretion system; Region: Effector_1; pfam04518 707185002264 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 707185002265 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 707185002266 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 707185002267 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 707185002268 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 707185002269 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 707185002270 active site 707185002271 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 707185002272 type III secretion system ATPase; Validated; Region: PRK05922 707185002273 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 707185002274 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 707185002275 Walker A motif; other site 707185002276 ATP binding site [chemical binding]; other site 707185002277 Walker B motif; other site 707185002278 type III secretion system protein; Validated; Region: PRK05934 707185002279 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 707185002280 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 707185002281 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 707185002282 active site 707185002283 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 707185002284 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 707185002285 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 707185002286 catalytic residue [active] 707185002287 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 707185002288 catalytic core [active] 707185002289 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 707185002290 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 707185002291 RNA binding surface [nucleotide binding]; other site 707185002292 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 707185002293 active site 707185002294 biotin--protein ligase; Provisional; Region: PRK05935 707185002295 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 707185002296 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 707185002297 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 707185002298 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 707185002299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 707185002300 motif II; other site 707185002301 CCC1-related protein family; Region: CCC1_like_1; cd02437 707185002302 seryl-tRNA synthetase; Provisional; Region: PRK05431 707185002303 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 707185002304 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 707185002305 dimer interface [polypeptide binding]; other site 707185002306 active site 707185002307 motif 1; other site 707185002308 motif 2; other site 707185002309 motif 3; other site 707185002310 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 707185002311 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 707185002312 catalytic motif [active] 707185002313 Zn binding site [ion binding]; other site 707185002314 RibD C-terminal domain; Region: RibD_C; pfam01872 707185002315 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 707185002316 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 707185002317 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 707185002318 dimerization interface [polypeptide binding]; other site 707185002319 active site 707185002320 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 707185002321 homopentamer interface [polypeptide binding]; other site 707185002322 active site 707185002323 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 707185002324 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 707185002325 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 707185002326 substrate binding site [chemical binding]; other site 707185002327 Proteins containing SET domain [General function prediction only]; Region: COG2940 707185002328 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 707185002329 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 707185002330 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 707185002331 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 707185002332 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 707185002333 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 707185002334 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 707185002335 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 707185002336 catalytic loop [active] 707185002337 iron binding site [ion binding]; other site 707185002338 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 707185002339 FAD binding pocket [chemical binding]; other site 707185002340 FAD binding motif [chemical binding]; other site 707185002341 phosphate binding motif [ion binding]; other site 707185002342 beta-alpha-beta structure motif; other site 707185002343 NAD binding pocket [chemical binding]; other site 707185002344 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 707185002345 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 707185002346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 707185002347 S-adenosylmethionine binding site [chemical binding]; other site 707185002348 Histone H1-like protein Hc1; Region: Hc1; pfam07432 707185002349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 707185002350 binding surface 707185002351 TPR motif; other site 707185002352 Tetratricopeptide repeat; Region: TPR_12; pfam13424 707185002353 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 707185002354 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 707185002355 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 707185002356 HemN C-terminal domain; Region: HemN_C; pfam06969 707185002357 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 707185002358 substrate binding site [chemical binding]; other site 707185002359 active site 707185002360 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 707185002361 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 707185002362 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 707185002363 ATP binding site [chemical binding]; other site 707185002364 putative Mg++ binding site [ion binding]; other site 707185002365 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 707185002366 nucleotide binding region [chemical binding]; other site 707185002367 ATP-binding site [chemical binding]; other site 707185002368 TRCF domain; Region: TRCF; pfam03461 707185002369 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 707185002370 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 707185002371 motif 1; other site 707185002372 active site 707185002373 motif 2; other site 707185002374 motif 3; other site 707185002375 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 707185002376 DHHA1 domain; Region: DHHA1; pfam02272 707185002377 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 707185002378 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 707185002379 TPP-binding site [chemical binding]; other site 707185002380 dimer interface [polypeptide binding]; other site 707185002381 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 707185002382 PYR/PP interface [polypeptide binding]; other site 707185002383 dimer interface [polypeptide binding]; other site 707185002384 TPP binding site [chemical binding]; other site 707185002385 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 707185002386 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 707185002387 elongation factor P; Validated; Region: PRK00529 707185002388 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 707185002389 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 707185002390 RNA binding site [nucleotide binding]; other site 707185002391 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 707185002392 RNA binding site [nucleotide binding]; other site 707185002393 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 707185002394 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 707185002395 putative active site [active] 707185002396 putative metal binding site [ion binding]; other site 707185002397 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 707185002398 active site 707185002399 metal binding site [ion binding]; metal-binding site 707185002400 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 707185002401 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 707185002402 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 707185002403 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 707185002404 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 707185002405 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 707185002406 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 707185002407 Mg++ binding site [ion binding]; other site 707185002408 putative catalytic motif [active] 707185002409 putative substrate binding site [chemical binding]; other site 707185002410 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 707185002411 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 707185002412 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 707185002413 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 707185002414 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 707185002415 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 707185002416 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 707185002417 cell division protein FtsW; Region: ftsW; TIGR02614 707185002418 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 707185002419 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 707185002420 active site 707185002421 homodimer interface [polypeptide binding]; other site 707185002422 bifunctional D-alanyl-alanine synthetase A/UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: PRK14573 707185002423 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 707185002424 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 707185002425 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 707185002426 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 707185002427 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 707185002428 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 707185002429 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409 707185002430 G-X-X-G motif; other site 707185002431 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 707185002432 anti sigma factor interaction site; other site 707185002433 regulatory phosphorylation site [posttranslational modification]; other site 707185002434 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 707185002435 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 707185002436 hypothetical protein; Provisional; Region: PRK05927 707185002437 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 707185002438 FeS/SAM binding site; other site 707185002439 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 707185002440 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 707185002441 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 707185002442 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 707185002443 dimer interface [polypeptide binding]; other site 707185002444 active site 707185002445 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 707185002446 active site 707185002447 Ap4A binding cleft/pocket [chemical binding]; other site 707185002448 P4 phosphate binding site; other site 707185002449 nudix motif; other site 707185002450 putative P2/P3 phosphate binding site [ion binding]; other site 707185002451 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 707185002452 dimer interface [polypeptide binding]; other site 707185002453 substrate binding site [chemical binding]; other site 707185002454 metal binding sites [ion binding]; metal-binding site 707185002455 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 707185002456 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 707185002457 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 707185002458 NAD binding site [chemical binding]; other site 707185002459 Phe binding site; other site 707185002460 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 707185002461 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 707185002462 active site 707185002463 putative lithium-binding site [ion binding]; other site 707185002464 substrate binding site [chemical binding]; other site 707185002465 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 707185002466 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 707185002467 putative acyl-acceptor binding pocket; other site 707185002468 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 707185002469 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 707185002470 acyl-activating enzyme (AAE) consensus motif; other site 707185002471 AMP binding site [chemical binding]; other site 707185002472 active site 707185002473 CoA binding site [chemical binding]; other site 707185002474 8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937 707185002475 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 707185002476 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 707185002477 catalytic residue [active] 707185002478 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 707185002479 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 707185002480 ATP binding site [chemical binding]; other site 707185002481 putative Mg++ binding site [ion binding]; other site 707185002482 helicase superfamily c-terminal domain; Region: HELICc; smart00490 707185002483 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 707185002484 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 707185002485 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 707185002486 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 707185002487 dimer interface [polypeptide binding]; other site 707185002488 putative anticodon binding site; other site 707185002489 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 707185002490 motif 1; other site 707185002491 dimer interface [polypeptide binding]; other site 707185002492 active site 707185002493 motif 2; other site 707185002494 motif 3; other site 707185002495 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 707185002496 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 707185002497 active site 707185002498 HIGH motif; other site 707185002499 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 707185002500 KMSKS motif; other site 707185002501 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 707185002502 tRNA binding surface [nucleotide binding]; other site 707185002503 anticodon binding site; other site 707185002504 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 707185002505 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 707185002506 ribonuclease P; Reviewed; Region: rnpA; PRK00730 707185002507 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 707185002508 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 707185002509 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 707185002510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 707185002511 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 707185002512 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 707185002513 GIY-YIG motif/motif A; other site 707185002514 active site 707185002515 catalytic site [active] 707185002516 putative DNA binding site [nucleotide binding]; other site 707185002517 metal binding site [ion binding]; metal-binding site 707185002518 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 707185002519 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 707185002520 MutS domain I; Region: MutS_I; pfam01624 707185002521 MutS domain II; Region: MutS_II; pfam05188 707185002522 MutS domain III; Region: MutS_III; pfam05192 707185002523 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 707185002524 Walker A/P-loop; other site 707185002525 ATP binding site [chemical binding]; other site 707185002526 Q-loop/lid; other site 707185002527 ABC transporter signature motif; other site 707185002528 Walker B; other site 707185002529 D-loop; other site 707185002530 H-loop/switch region; other site 707185002531 DNA primase; Validated; Region: dnaG; PRK05667 707185002532 CHC2 zinc finger; Region: zf-CHC2; pfam01807 707185002533 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 707185002534 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 707185002535 active site 707185002536 metal binding site [ion binding]; metal-binding site 707185002537 interdomain interaction site; other site 707185002538 glycyl-tRNA synthetase; Provisional; Region: PRK14908 707185002539 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 707185002540 dimer interface [polypeptide binding]; other site 707185002541 motif 1; other site 707185002542 active site 707185002543 motif 2; other site 707185002544 motif 3; other site 707185002545 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 707185002546 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 707185002547 glycogen synthase; Provisional; Region: glgA; PRK00654 707185002548 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 707185002549 ADP-binding pocket [chemical binding]; other site 707185002550 homodimer interface [polypeptide binding]; other site 707185002551 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 707185002552 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 707185002553 5S rRNA interface [nucleotide binding]; other site 707185002554 CTC domain interface [polypeptide binding]; other site 707185002555 L16 interface [polypeptide binding]; other site 707185002556 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 707185002557 putative active site [active] 707185002558 catalytic residue [active] 707185002559 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 707185002560 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 707185002561 Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359 707185002562 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 707185002563 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 707185002564 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK00650 707185002565 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 707185002566 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 707185002567 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 707185002568 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 707185002569 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 707185002570 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 707185002571 putative acyl-acceptor binding pocket; other site 707185002572 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 707185002573 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 707185002574 homodimer interface [polypeptide binding]; other site 707185002575 oligonucleotide binding site [chemical binding]; other site 707185002576 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 707185002577 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 707185002578 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 707185002579 Autotransporter beta-domain; Region: Autotransporter; pfam03797 707185002580 YtxH-like protein; Region: YtxH; cl02079 707185002581 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 707185002582 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 707185002583 active site 707185002584 substrate binding site [chemical binding]; other site 707185002585 metal binding site [ion binding]; metal-binding site 707185002586 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 707185002587 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 707185002588 glutaminase active site [active] 707185002589 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 707185002590 dimer interface [polypeptide binding]; other site 707185002591 active site 707185002592 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 707185002593 dimer interface [polypeptide binding]; other site 707185002594 active site 707185002595 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 707185002596 aromatic amino acid transport protein; Region: araaP; TIGR00837 707185002597 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 707185002598 aromatic amino acid transport protein; Region: araaP; TIGR00837 707185002599 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 707185002600 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 707185002601 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 707185002602 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 707185002603 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 707185002604 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 707185002605 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 707185002606 CoA-ligase; Region: Ligase_CoA; pfam00549 707185002607 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 707185002608 CoA binding domain; Region: CoA_binding; smart00881 707185002609 CoA-ligase; Region: Ligase_CoA; pfam00549 707185002610 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 707185002611 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 707185002612 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 707185002613 protein binding site [polypeptide binding]; other site 707185002614 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 707185002615 protein binding site [polypeptide binding]; other site 707185002616 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 707185002617 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 707185002618 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 707185002619 Peptidase M16C associated; Region: M16C_assoc; pfam08367 707185002620 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 707185002621 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 707185002622 RmuC family; Region: RmuC; pfam02646 707185002623 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 707185002624 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 707185002625 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 707185002626 ATP cone domain; Region: ATP-cone; pfam03477 707185002627 ATP cone domain; Region: ATP-cone; pfam03477 707185002628 Class I ribonucleotide reductase; Region: RNR_I; cd01679 707185002629 active site 707185002630 dimer interface [polypeptide binding]; other site 707185002631 catalytic residues [active] 707185002632 effector binding site; other site 707185002633 R2 peptide binding site; other site 707185002634 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 707185002635 dimer interface [polypeptide binding]; other site 707185002636 putative radical transfer pathway; other site 707185002637 diiron center [ion binding]; other site 707185002638 tyrosyl radical; other site 707185002639 Putative methyltransferase; Region: Methyltransf_4; pfam02390 707185002640 Methyltransferase domain; Region: Methyltransf_18; pfam12847 707185002641 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 707185002642 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 707185002643 FAD binding domain; Region: FAD_binding_4; pfam01565 707185002644 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 707185002645 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 707185002646 putative RNA binding site [nucleotide binding]; other site 707185002647 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 707185002648 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 707185002649 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 707185002650 Ribosomal protein L35 [Translation, ribosomal structure and biogenesis]; Region: RpmI; COG0291 707185002651 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 707185002652 23S rRNA binding site [nucleotide binding]; other site 707185002653 L21 binding site [polypeptide binding]; other site 707185002654 L13 binding site [polypeptide binding]; other site 707185002655 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 707185002656 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 707185002657 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 707185002658 motif 1; other site 707185002659 dimer interface [polypeptide binding]; other site 707185002660 active site 707185002661 motif 2; other site 707185002662 motif 3; other site 707185002663 potential protein location (hypothetical protein G9768_04450 [Chlamydia trachomatis G/9768]) that overlaps RNA (tRNA-S) 707185002664 Predicted permeases [General function prediction only]; Region: COG0795 707185002665 Predicted permeases [General function prediction only]; Region: COG0795 707185002666 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 707185002667 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 707185002668 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 707185002669 Ligand Binding Site [chemical binding]; other site 707185002670 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 707185002671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 707185002672 Walker A motif; other site 707185002673 ATP binding site [chemical binding]; other site 707185002674 Walker B motif; other site 707185002675 arginine finger; other site 707185002676 Peptidase family M41; Region: Peptidase_M41; pfam01434 707185002677 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 707185002678 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 707185002679 RNase E interface [polypeptide binding]; other site 707185002680 trimer interface [polypeptide binding]; other site 707185002681 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 707185002682 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 707185002683 RNase E interface [polypeptide binding]; other site 707185002684 trimer interface [polypeptide binding]; other site 707185002685 active site 707185002686 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 707185002687 putative nucleic acid binding region [nucleotide binding]; other site 707185002688 G-X-X-G motif; other site 707185002689 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 707185002690 RNA binding site [nucleotide binding]; other site 707185002691 domain interface; other site 707185002692 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 707185002693 16S/18S rRNA binding site [nucleotide binding]; other site 707185002694 S13e-L30e interaction site [polypeptide binding]; other site 707185002695 25S rRNA binding site [nucleotide binding]; other site 707185002696 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 707185002697 nucleoside/Zn binding site; other site 707185002698 dimer interface [polypeptide binding]; other site 707185002699 catalytic motif [active] 707185002700 Protein of unknown function (DUF720); Region: DUF720; pfam05302 707185002701 Protein of unknown function (DUF720); Region: DUF720; pfam05302 707185002702 Protein of unknown function (DUF720); Region: DUF720; pfam05302 707185002703 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 707185002704 methionine aminopeptidase; Provisional; Region: PRK12318 707185002705 SEC-C motif; Region: SEC-C; pfam02810 707185002706 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 707185002707 active site 707185002708 MarC family integral membrane protein; Region: MarC; pfam01914 707185002709 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 707185002710 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 707185002711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 707185002712 dimer interface [polypeptide binding]; other site 707185002713 conserved gate region; other site 707185002714 putative PBP binding loops; other site 707185002715 ABC-ATPase subunit interface; other site 707185002716 NMT1/THI5 like; Region: NMT1; pfam09084 707185002717 fumarate hydratase, class II; Region: fumC_II; TIGR00979 707185002718 Class II fumarases; Region: Fumarase_classII; cd01362 707185002719 active site 707185002720 tetramer interface [polypeptide binding]; other site 707185002721 high affinity sulphate transporter 1; Region: sulP; TIGR00815 707185002722 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 707185002723 Sulfate transporter family; Region: Sulfate_transp; pfam00916 707185002724 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 707185002725 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 707185002726 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 707185002727 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 707185002728 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 707185002729 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 707185002730 active site triad [active] 707185002731 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 707185002732 LytB protein; Region: LYTB; pfam02401 707185002733 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 707185002734 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 707185002735 binding surface 707185002736 TPR motif; other site 707185002737 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 707185002738 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 707185002739 active site 707185002740 DNA binding site [nucleotide binding] 707185002741 Int/Topo IB signature motif; other site 707185002742 glycogen branching enzyme; Provisional; Region: PRK05402 707185002743 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 707185002744 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 707185002745 active site 707185002746 catalytic site [active] 707185002747 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 707185002748 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 707185002749 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 707185002750 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 707185002751 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 707185002752 Autotransporter beta-domain; Region: Autotransporter; pfam03797 707185002753 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 707185002754 Autotransporter beta-domain; Region: Autotransporter; pfam03797 707185002755 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 707185002756 Autotransporter beta-domain; Region: Autotransporter; pfam03797 707185002757 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 707185002758 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 707185002759 Autotransporter beta-domain; Region: Autotransporter; pfam03797 707185002760 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 707185002761 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 707185002762 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 707185002763 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 707185002764 Autotransporter beta-domain; Region: Autotransporter; pfam03797