-- dump date 20140619_033034 -- class Genbank::misc_feature -- table misc_feature_note -- id note 718219000001 Uncharacterized conserved protein [Function unknown]; Region: COG2155 718219000002 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 718219000003 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 718219000004 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 718219000005 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 718219000006 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 718219000007 GatB domain; Region: GatB_Yqey; pfam02637 718219000008 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 718219000009 ribonuclease HIII; Region: rnhC; TIGR00716 718219000010 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 718219000011 RNA/DNA hybrid binding site [nucleotide binding]; other site 718219000012 active site 718219000013 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 718219000014 Helix-turn-helix domain; Region: HTH_25; pfam13413 718219000015 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906 718219000016 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 718219000017 putative acyl-acceptor binding pocket; other site 718219000018 Uncharacterized conserved protein [Function unknown]; Region: COG1624 718219000019 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 718219000020 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 718219000021 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 718219000022 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 718219000023 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 718219000024 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 718219000025 putative active site [active] 718219000026 PhoH-like protein; Region: PhoH; pfam02562 718219000027 Bacterial SH3 domain homologues; Region: SH3b; smart00287 718219000028 Bacterial SH3 domain homologues; Region: SH3b; smart00287 718219000029 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 718219000030 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 718219000031 HIGH motif; other site 718219000032 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 718219000033 active site 718219000034 KMSKS motif; other site 718219000035 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 718219000036 tRNA binding surface [nucleotide binding]; other site 718219000037 anticodon binding site; other site 718219000038 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 718219000039 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 718219000040 Catalytic site [active] 718219000041 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 718219000042 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 718219000043 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 718219000044 peptide chain release factor 1; Validated; Region: prfA; PRK00591 718219000045 PCRF domain; Region: PCRF; pfam03462 718219000046 RF-1 domain; Region: RF-1; pfam00472 718219000047 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 718219000048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718219000049 S-adenosylmethionine binding site [chemical binding]; other site 718219000050 signal recognition particle protein; Provisional; Region: PRK10867 718219000051 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 718219000052 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 718219000053 P loop; other site 718219000054 GTP binding site [chemical binding]; other site 718219000055 Signal peptide binding domain; Region: SRP_SPB; pfam02978 718219000056 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 718219000057 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 718219000058 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 718219000059 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 718219000060 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 718219000061 RNA/DNA hybrid binding site [nucleotide binding]; other site 718219000062 active site 718219000063 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 718219000064 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 718219000065 catalytic site [active] 718219000066 G-X2-G-X-G-K; other site 718219000067 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 718219000068 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 718219000069 active site 718219000070 HIGH motif; other site 718219000071 KMSKS motif; other site 718219000072 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 718219000073 tRNA binding surface [nucleotide binding]; other site 718219000074 anticodon binding site; other site 718219000075 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 718219000076 AAA domain; Region: AAA_30; pfam13604 718219000077 Family description; Region: UvrD_C_2; pfam13538 718219000078 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 718219000079 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 718219000080 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 718219000081 conserved cys residue [active] 718219000082 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 718219000083 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 718219000084 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 718219000085 trimer interface [polypeptide binding]; other site 718219000086 active site 718219000087 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 718219000088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718219000089 Walker A motif; other site 718219000090 ATP binding site [chemical binding]; other site 718219000091 Walker B motif; other site 718219000092 arginine finger; other site 718219000093 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 718219000094 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 718219000095 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 718219000096 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 718219000097 active site 718219000098 catalytic site [active] 718219000099 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 718219000100 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 718219000101 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 718219000102 dimer interface [polypeptide binding]; other site 718219000103 ssDNA binding site [nucleotide binding]; other site 718219000104 tetramer (dimer of dimers) interface [polypeptide binding]; other site 718219000105 multifunctional aminopeptidase A; Provisional; Region: PRK00913 718219000106 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 718219000107 interface (dimer of trimers) [polypeptide binding]; other site 718219000108 Substrate-binding/catalytic site; other site 718219000109 Zn-binding sites [ion binding]; other site 718219000110 hypothetical protein; Provisional; Region: PRK05907 718219000111 Predicted methyltransferases [General function prediction only]; Region: COG0313 718219000112 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 718219000113 putative SAM binding site [chemical binding]; other site 718219000114 homodimer interface [polypeptide binding]; other site 718219000115 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 718219000116 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718219000117 FeS/SAM binding site; other site 718219000118 HemN C-terminal domain; Region: HemN_C; pfam06969 718219000119 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 718219000120 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 718219000121 TPP-binding site [chemical binding]; other site 718219000122 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 718219000123 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 718219000124 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 718219000125 E3 interaction surface; other site 718219000126 lipoyl attachment site [posttranslational modification]; other site 718219000127 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 718219000128 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 718219000129 uncharacterized protein, YfiH family; Region: TIGR00726 718219000130 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 718219000131 1-hydroxy-2-methyl-2-(e)-butenyl 4-diphosphate synthase [Lipid metabolism]; Region: gcpE; COG0821 718219000132 IncA protein; Region: IncA; pfam04156 718219000133 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 718219000134 ADP-ribose binding site [chemical binding]; other site 718219000135 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 718219000136 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 718219000137 catalytic loop [active] 718219000138 iron binding site [ion binding]; other site 718219000139 type III secretion system protein; Validated; Region: PRK05910 718219000140 FHIPEP family; Region: FHIPEP; pfam00771 718219000141 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 718219000142 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 718219000143 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 718219000144 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 718219000145 DNA binding residues [nucleotide binding] 718219000146 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 718219000147 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 718219000148 active site 718219000149 HIGH motif; other site 718219000150 dimer interface [polypeptide binding]; other site 718219000151 KMSKS motif; other site 718219000152 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718219000153 RNA binding surface [nucleotide binding]; other site 718219000154 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 718219000155 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 718219000156 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 718219000157 GTP-binding protein LepA; Provisional; Region: PRK05433 718219000158 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 718219000159 G1 box; other site 718219000160 putative GEF interaction site [polypeptide binding]; other site 718219000161 GTP/Mg2+ binding site [chemical binding]; other site 718219000162 Switch I region; other site 718219000163 G2 box; other site 718219000164 G3 box; other site 718219000165 Switch II region; other site 718219000166 G4 box; other site 718219000167 G5 box; other site 718219000168 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 718219000169 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 718219000170 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 718219000171 ADP/ATP carrier protein family; Region: AAA; TIGR00769 718219000172 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 718219000173 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 718219000174 intersubunit interface [polypeptide binding]; other site 718219000175 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 718219000176 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 718219000177 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 718219000178 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718219000179 ABC-ATPase subunit interface; other site 718219000180 dimer interface [polypeptide binding]; other site 718219000181 putative PBP binding regions; other site 718219000182 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 718219000183 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 718219000184 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 718219000185 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718219000186 ABC-ATPase subunit interface; other site 718219000187 dimer interface [polypeptide binding]; other site 718219000188 putative PBP binding regions; other site 718219000189 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 718219000190 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 718219000191 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 718219000192 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 718219000193 RIP metalloprotease RseP; Region: TIGR00054 718219000194 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 718219000195 active site 718219000196 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 718219000197 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 718219000198 putative substrate binding region [chemical binding]; other site 718219000199 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 718219000200 Putative serine esterase (DUF676); Region: DUF676; pfam05057 718219000201 recF protein; Region: recf; TIGR00611 718219000202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718219000203 Walker A/P-loop; other site 718219000204 ATP binding site [chemical binding]; other site 718219000205 Q-loop/lid; other site 718219000206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718219000207 ABC transporter signature motif; other site 718219000208 Walker B; other site 718219000209 DNA polymerase III subunit beta; Validated; Region: PRK05643 718219000210 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 718219000211 putative DNA binding surface [nucleotide binding]; other site 718219000212 dimer interface [polypeptide binding]; other site 718219000213 beta-clamp/clamp loader binding surface; other site 718219000214 beta-clamp/translesion DNA polymerase binding surface; other site 718219000215 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 718219000216 SmpB-tmRNA interface; other site 718219000217 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 718219000218 ApbE family; Region: ApbE; pfam02424 718219000219 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 718219000220 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 718219000221 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 718219000222 homodimer interface [polypeptide binding]; other site 718219000223 NADP binding site [chemical binding]; other site 718219000224 substrate binding site [chemical binding]; other site 718219000225 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 718219000226 PLD-like domain; Region: PLDc_2; pfam13091 718219000227 putative active site [active] 718219000228 catalytic site [active] 718219000229 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 718219000230 PLD-like domain; Region: PLDc_2; pfam13091 718219000231 putative active site [active] 718219000232 catalytic site [active] 718219000233 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 718219000234 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 718219000235 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 718219000236 4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446 718219000237 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 718219000238 HrpJ-like domain; Region: HrpJ; cl15454 718219000239 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 718219000240 FHIPEP family; Region: FHIPEP; pfam00771 718219000241 type III secretion system protein; Validated; Region: PRK06298 718219000242 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 718219000243 GTP-binding protein YchF; Reviewed; Region: PRK09601 718219000244 YchF GTPase; Region: YchF; cd01900 718219000245 G1 box; other site 718219000246 GTP/Mg2+ binding site [chemical binding]; other site 718219000247 Switch I region; other site 718219000248 G2 box; other site 718219000249 Switch II region; other site 718219000250 G3 box; other site 718219000251 G4 box; other site 718219000252 G5 box; other site 718219000253 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 718219000254 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 718219000255 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 718219000256 active site 718219000257 Riboflavin kinase; Region: Flavokinase; smart00904 718219000258 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 718219000259 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 718219000260 RNA binding site [nucleotide binding]; other site 718219000261 active site 718219000262 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 718219000263 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 718219000264 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 718219000265 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 718219000266 G1 box; other site 718219000267 putative GEF interaction site [polypeptide binding]; other site 718219000268 GTP/Mg2+ binding site [chemical binding]; other site 718219000269 Switch I region; other site 718219000270 G2 box; other site 718219000271 G3 box; other site 718219000272 Switch II region; other site 718219000273 G4 box; other site 718219000274 G5 box; other site 718219000275 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 718219000276 Translation-initiation factor 2; Region: IF-2; pfam11987 718219000277 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 718219000278 transcription termination factor NusA; Region: NusA; TIGR01953 718219000279 NusA N-terminal domain; Region: NusA_N; pfam08529 718219000280 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 718219000281 RNA binding site [nucleotide binding]; other site 718219000282 homodimer interface [polypeptide binding]; other site 718219000283 NusA-like KH domain; Region: KH_5; pfam13184 718219000284 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 718219000285 G-X-X-G motif; other site 718219000286 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 718219000287 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 718219000288 RNA binding site [nucleotide binding]; other site 718219000289 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 718219000290 RNA binding site [nucleotide binding]; other site 718219000291 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 718219000292 RNA binding site [nucleotide binding]; other site 718219000293 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 718219000294 RNA binding site [nucleotide binding]; other site 718219000295 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 718219000296 RNA binding site [nucleotide binding]; other site 718219000297 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 718219000298 RNA binding site [nucleotide binding]; other site 718219000299 domain interface; other site 718219000300 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 718219000301 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 718219000302 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718219000303 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 718219000304 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 718219000305 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 718219000306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 718219000307 active site 718219000308 motif I; other site 718219000309 motif II; other site 718219000310 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 718219000311 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 718219000312 NAD binding site [chemical binding]; other site 718219000313 homotetramer interface [polypeptide binding]; other site 718219000314 homodimer interface [polypeptide binding]; other site 718219000315 substrate binding site [chemical binding]; other site 718219000316 active site 718219000317 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 718219000318 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718219000319 RNA binding surface [nucleotide binding]; other site 718219000320 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 718219000321 active site 718219000322 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 718219000323 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 718219000324 minor groove reading motif; other site 718219000325 helix-hairpin-helix signature motif; other site 718219000326 substrate binding pocket [chemical binding]; other site 718219000327 active site 718219000328 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 718219000329 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 718219000330 DNA binding and oxoG recognition site [nucleotide binding] 718219000331 Uncharacterized conserved protein [Function unknown]; Region: COG0327 718219000332 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 718219000333 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 718219000334 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 718219000335 ring oligomerisation interface [polypeptide binding]; other site 718219000336 ATP/Mg binding site [chemical binding]; other site 718219000337 stacking interactions; other site 718219000338 hinge regions; other site 718219000339 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 718219000340 oligomerisation interface [polypeptide binding]; other site 718219000341 mobile loop; other site 718219000342 roof hairpin; other site 718219000343 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 718219000344 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 718219000345 active site 718219000346 Zn binding site [ion binding]; other site 718219000347 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 718219000348 Clp amino terminal domain; Region: Clp_N; pfam02861 718219000349 Clp amino terminal domain; Region: Clp_N; pfam02861 718219000350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718219000351 Walker A motif; other site 718219000352 ATP binding site [chemical binding]; other site 718219000353 Walker B motif; other site 718219000354 arginine finger; other site 718219000355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718219000356 Walker A motif; other site 718219000357 ATP binding site [chemical binding]; other site 718219000358 Walker B motif; other site 718219000359 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 718219000360 Uncharacterized conserved protein [Function unknown]; Region: COG2912 718219000361 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 718219000362 IncA protein; Region: IncA; pfam04156 718219000363 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 718219000364 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 718219000365 substrate binding site [chemical binding]; other site 718219000366 hexamer interface [polypeptide binding]; other site 718219000367 metal binding site [ion binding]; metal-binding site 718219000368 elongation factor P; Provisional; Region: PRK12426 718219000369 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 718219000370 RNA binding site [nucleotide binding]; other site 718219000371 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 718219000372 RNA binding site [nucleotide binding]; other site 718219000373 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 718219000374 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 718219000375 carboxyltransferase (CT) interaction site; other site 718219000376 biotinylation site [posttranslational modification]; other site 718219000377 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 718219000378 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 718219000379 ATP-grasp domain; Region: ATP-grasp_4; cl17255 718219000380 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 718219000381 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 718219000382 23S rRNA interface [nucleotide binding]; other site 718219000383 L3 interface [polypeptide binding]; other site 718219000384 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 718219000385 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 718219000386 NlpC/P60 family; Region: NLPC_P60; cl17555 718219000387 adenylate kinase; Region: adk; TIGR01351 718219000388 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 718219000389 AMP-binding site [chemical binding]; other site 718219000390 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 718219000391 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 718219000392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718219000393 dimer interface [polypeptide binding]; other site 718219000394 conserved gate region; other site 718219000395 putative PBP binding loops; other site 718219000396 ABC-ATPase subunit interface; other site 718219000397 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 718219000398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718219000399 Walker A/P-loop; other site 718219000400 ATP binding site [chemical binding]; other site 718219000401 Q-loop/lid; other site 718219000402 ABC transporter signature motif; other site 718219000403 Walker B; other site 718219000404 D-loop; other site 718219000405 H-loop/switch region; other site 718219000406 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 718219000407 Methyltransferase domain; Region: Methyltransf_23; pfam13489 718219000408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718219000409 S-adenosylmethionine binding site [chemical binding]; other site 718219000410 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 718219000411 Serine hydrolase (FSH1); Region: FSH1; pfam03959 718219000412 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 718219000413 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 718219000414 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 718219000415 active site 718219000416 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 718219000417 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 718219000418 conserved hypothetical integral membrane protein; Region: TIGR00697 718219000419 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 718219000420 SEC-C motif; Region: SEC-C; pfam02810 718219000421 potential protein location (hypothetical protein CTG9301_00730 [Chlamydia trachomatis G/9301]) that overlaps RNA (tRNA-T) 718219000422 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 718219000423 Catalytic domain of Protein Kinases; Region: PKc; cd00180 718219000424 active site 718219000425 ATP binding site [chemical binding]; other site 718219000426 substrate binding site [chemical binding]; other site 718219000427 activation loop (A-loop); other site 718219000428 Uncharacterized conserved protein [Function unknown]; Region: COG1262 718219000429 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 718219000430 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 718219000431 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 718219000432 nucleotide binding pocket [chemical binding]; other site 718219000433 K-X-D-G motif; other site 718219000434 catalytic site [active] 718219000435 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 718219000436 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 718219000437 Helix-hairpin-helix motif; Region: HHH; pfam00633 718219000438 helix-hairpin-helix signature motif; other site 718219000439 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 718219000440 Dimer interface [polypeptide binding]; other site 718219000441 BRCT sequence motif; other site 718219000442 hypothetical protein; Provisional; Region: PRK06184 718219000443 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 718219000444 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 718219000445 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 718219000446 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 718219000447 FtsX-like permease family; Region: FtsX; pfam02687 718219000448 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 718219000449 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 718219000450 Walker A/P-loop; other site 718219000451 ATP binding site [chemical binding]; other site 718219000452 Q-loop/lid; other site 718219000453 ABC transporter signature motif; other site 718219000454 Walker B; other site 718219000455 D-loop; other site 718219000456 H-loop/switch region; other site 718219000457 membrane-attack complex / perforin; Region: MACPF; smart00457 718219000458 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 718219000459 potential frameshift: common BLAST hit: gi|15604873|ref|NP_219657.1| phospholipase D endonuclease superfamily protein 718219000460 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 718219000461 PLD-like domain; Region: PLDc_2; pfam13091 718219000462 putative active site [active] 718219000463 catalytic site [active] 718219000464 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 718219000465 PLD-like domain; Region: PLDc_2; pfam13091 718219000466 putative active site [active] 718219000467 catalytic site [active] 718219000468 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 718219000469 PLD-like domain; Region: PLDc_2; pfam13091 718219000470 putative active site [active] 718219000471 catalytic site [active] 718219000472 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 718219000473 PLD-like domain; Region: PLDc_2; pfam13091 718219000474 putative active site [active] 718219000475 catalytic site [active] 718219000476 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 718219000477 PLD-like domain; Region: PLDc_2; pfam13091 718219000478 putative active site [active] 718219000479 catalytic site [active] 718219000480 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 718219000481 potential frameshift: common BLAST hit: gi|15835056|ref|NP_296815.1| adherence factor 718219000482 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 718219000483 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 718219000484 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 718219000485 trp operon repressor, proteobacterial; Region: TrpR; TIGR01321 718219000486 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 718219000487 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 718219000488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718219000489 catalytic residue [active] 718219000490 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 718219000491 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 718219000492 substrate binding site [chemical binding]; other site 718219000493 active site 718219000494 catalytic residues [active] 718219000495 heterodimer interface [polypeptide binding]; other site 718219000496 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 718219000497 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 718219000498 peptide binding site [polypeptide binding]; other site 718219000499 putative disulfide oxidoreductase; Provisional; Region: PRK00611 718219000500 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 718219000501 Thioredoxin; Region: Thioredoxin_4; cl17273 718219000502 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 718219000503 putative active site [active] 718219000504 redox center [active] 718219000505 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 718219000506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718219000507 Walker A/P-loop; other site 718219000508 ATP binding site [chemical binding]; other site 718219000509 Q-loop/lid; other site 718219000510 ABC transporter signature motif; other site 718219000511 Walker B; other site 718219000512 D-loop; other site 718219000513 H-loop/switch region; other site 718219000514 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 718219000515 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 718219000516 Ligand binding site; other site 718219000517 oligomer interface; other site 718219000518 CTP synthetase; Validated; Region: pyrG; PRK05380 718219000519 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 718219000520 Catalytic site [active] 718219000521 active site 718219000522 UTP binding site [chemical binding]; other site 718219000523 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 718219000524 active site 718219000525 putative oxyanion hole; other site 718219000526 catalytic triad [active] 718219000527 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 718219000528 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 718219000529 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 718219000530 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 718219000531 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 718219000532 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 718219000533 putative active site [active] 718219000534 DNA polymerase III subunit delta'; Validated; Region: PRK05917 718219000535 DNA polymerase III subunit delta'; Validated; Region: PRK08485 718219000536 thymidylate kinase; Validated; Region: tmk; PRK00698 718219000537 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 718219000538 TMP-binding site; other site 718219000539 ATP-binding site [chemical binding]; other site 718219000540 DNA gyrase, A subunit; Region: gyrA; TIGR01063 718219000541 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 718219000542 CAP-like domain; other site 718219000543 active site 718219000544 primary dimer interface [polypeptide binding]; other site 718219000545 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718219000546 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718219000547 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718219000548 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718219000549 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718219000550 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718219000551 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 718219000552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718219000553 ATP binding site [chemical binding]; other site 718219000554 Mg2+ binding site [ion binding]; other site 718219000555 G-X-G motif; other site 718219000556 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 718219000557 anchoring element; other site 718219000558 dimer interface [polypeptide binding]; other site 718219000559 ATP binding site [chemical binding]; other site 718219000560 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 718219000561 active site 718219000562 putative metal-binding site [ion binding]; other site 718219000563 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 718219000564 Protein of unknown function (DUF721); Region: DUF721; pfam05258 718219000565 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 718219000566 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 718219000567 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 718219000568 MgtE intracellular N domain; Region: MgtE_N; pfam03448 718219000569 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 718219000570 Divalent cation transporter; Region: MgtE; pfam01769 718219000571 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 718219000572 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 718219000573 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 718219000574 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 718219000575 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 718219000576 peptide binding site [polypeptide binding]; other site 718219000577 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 718219000578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718219000579 dimer interface [polypeptide binding]; other site 718219000580 conserved gate region; other site 718219000581 putative PBP binding loops; other site 718219000582 ABC-ATPase subunit interface; other site 718219000583 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 718219000584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718219000585 dimer interface [polypeptide binding]; other site 718219000586 conserved gate region; other site 718219000587 putative PBP binding loops; other site 718219000588 ABC-ATPase subunit interface; other site 718219000589 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718219000590 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 718219000591 Walker A/P-loop; other site 718219000592 ATP binding site [chemical binding]; other site 718219000593 Q-loop/lid; other site 718219000594 ABC transporter signature motif; other site 718219000595 Walker B; other site 718219000596 D-loop; other site 718219000597 H-loop/switch region; other site 718219000598 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 718219000599 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 718219000600 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718219000601 Walker A/P-loop; other site 718219000602 ATP binding site [chemical binding]; other site 718219000603 Q-loop/lid; other site 718219000604 ABC transporter signature motif; other site 718219000605 Walker B; other site 718219000606 D-loop; other site 718219000607 H-loop/switch region; other site 718219000608 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 718219000609 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 718219000610 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 718219000611 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 718219000612 transmembrane helices; other site 718219000613 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 718219000614 active site 718219000615 ADP/pyrophosphate binding site [chemical binding]; other site 718219000616 dimerization interface [polypeptide binding]; other site 718219000617 allosteric effector site; other site 718219000618 fructose-1,6-bisphosphate binding site; other site 718219000619 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 718219000620 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 718219000621 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 718219000622 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 718219000623 active site 718219000624 ADP/pyrophosphate binding site [chemical binding]; other site 718219000625 dimerization interface [polypeptide binding]; other site 718219000626 allosteric effector site; other site 718219000627 fructose-1,6-bisphosphate binding site; other site 718219000628 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 718219000629 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 718219000630 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 718219000631 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 718219000632 HIGH motif; other site 718219000633 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 718219000634 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 718219000635 active site 718219000636 KMSKS motif; other site 718219000637 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 718219000638 tRNA binding surface [nucleotide binding]; other site 718219000639 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00615 718219000640 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 718219000641 inhibitor-cofactor binding pocket; inhibition site 718219000642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718219000643 catalytic residue [active] 718219000644 Putative transcriptional regulator [Transcription]; Region: COG1678 718219000645 Uncharacterized conserved protein [Function unknown]; Region: COG1259 718219000646 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 718219000647 tetramer (dimer of dimers) interface [polypeptide binding]; other site 718219000648 active site 718219000649 dimer interface [polypeptide binding]; other site 718219000650 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 718219000651 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 718219000652 putative active site; other site 718219000653 catalytic residue [active] 718219000654 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 718219000655 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 718219000656 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 718219000657 Ligand Binding Site [chemical binding]; other site 718219000658 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 718219000659 prenyltransferase; Reviewed; Region: ubiA; PRK12876 718219000660 UbiA prenyltransferase family; Region: UbiA; pfam01040 718219000661 aromatic acid decarboxylase; Validated; Region: PRK05920 718219000662 Flavoprotein; Region: Flavoprotein; pfam02441 718219000663 Uncharacterized conserved protein [Function unknown]; Region: COG1284 718219000664 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 718219000665 IncA protein; Region: IncA; pfam04156 718219000666 IncA protein; Region: IncA; pfam04156 718219000667 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 718219000668 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 718219000669 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 718219000670 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 718219000671 Na2 binding site [ion binding]; other site 718219000672 putative substrate binding site 1 [chemical binding]; other site 718219000673 Na binding site 1 [ion binding]; other site 718219000674 putative substrate binding site 2 [chemical binding]; other site 718219000675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718219000676 putative substrate translocation pore; other site 718219000677 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 718219000678 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 718219000679 ligand binding site [chemical binding]; other site 718219000680 flexible hinge region; other site 718219000681 acyl carrier protein; Provisional; Region: acpP; PRK00982 718219000682 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 718219000683 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 718219000684 NAD(P) binding site [chemical binding]; other site 718219000685 homotetramer interface [polypeptide binding]; other site 718219000686 homodimer interface [polypeptide binding]; other site 718219000687 active site 718219000688 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 718219000689 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 718219000690 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 718219000691 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 718219000692 dimer interface [polypeptide binding]; other site 718219000693 active site 718219000694 CoA binding pocket [chemical binding]; other site 718219000695 recombination protein RecR; Region: recR; TIGR00615 718219000696 RecR protein; Region: RecR; pfam02132 718219000697 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 718219000698 putative active site [active] 718219000699 putative metal-binding site [ion binding]; other site 718219000700 tetramer interface [polypeptide binding]; other site 718219000701 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 718219000702 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 718219000703 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 718219000704 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 718219000705 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 718219000706 Surface antigen; Region: Bac_surface_Ag; pfam01103 718219000707 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 718219000708 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 718219000709 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 718219000710 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 718219000711 trimer interface [polypeptide binding]; other site 718219000712 active site 718219000713 UDP-GlcNAc binding site [chemical binding]; other site 718219000714 lipid binding site [chemical binding]; lipid-binding site 718219000715 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 718219000716 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 718219000717 tetramer interface [polypeptide binding]; other site 718219000718 TPP-binding site [chemical binding]; other site 718219000719 heterodimer interface [polypeptide binding]; other site 718219000720 phosphorylation loop region [posttranslational modification] 718219000721 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 718219000722 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 718219000723 alpha subunit interface [polypeptide binding]; other site 718219000724 TPP binding site [chemical binding]; other site 718219000725 heterodimer interface [polypeptide binding]; other site 718219000726 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 718219000727 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 718219000728 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 718219000729 E3 interaction surface; other site 718219000730 lipoyl attachment site [posttranslational modification]; other site 718219000731 e3 binding domain; Region: E3_binding; pfam02817 718219000732 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 718219000733 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 718219000734 homodimer interface [polypeptide binding]; other site 718219000735 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 718219000736 active site pocket [active] 718219000737 chromosomal replication initiation protein; Provisional; Region: PRK12422 718219000738 DnaA N-terminal domain; Region: DnaA_N; pfam11638 718219000739 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718219000740 Walker A motif; other site 718219000741 ATP binding site [chemical binding]; other site 718219000742 Walker B motif; other site 718219000743 arginine finger; other site 718219000744 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 718219000745 DnaA box-binding interface [nucleotide binding]; other site 718219000746 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 718219000747 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 718219000748 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 718219000749 CAAX protease self-immunity; Region: Abi; pfam02517 718219000750 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 718219000751 homodimer interface [polypeptide binding]; other site 718219000752 metal binding site [ion binding]; metal-binding site 718219000753 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 718219000754 Domain of unknown function DUF21; Region: DUF21; pfam01595 718219000755 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 718219000756 Transporter associated domain; Region: CorC_HlyC; smart01091 718219000757 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 718219000758 Domain of unknown function DUF21; Region: DUF21; pfam01595 718219000759 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 718219000760 Transporter associated domain; Region: CorC_HlyC; smart01091 718219000761 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 718219000762 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 718219000763 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718219000764 catalytic residue [active] 718219000765 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 718219000766 Protein phosphatase 2C; Region: PP2C; pfam00481 718219000767 active site 718219000768 Uncharacterized conserved protein [Function unknown]; Region: COG5465 718219000769 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 718219000770 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 718219000771 active site 718219000772 catalytic site [active] 718219000773 substrate binding site [chemical binding]; other site 718219000774 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 718219000775 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 718219000776 nucleosidase; Provisional; Region: PRK05634 718219000777 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 718219000778 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 718219000779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718219000780 Walker A/P-loop; other site 718219000781 ATP binding site [chemical binding]; other site 718219000782 Q-loop/lid; other site 718219000783 ABC transporter signature motif; other site 718219000784 Walker B; other site 718219000785 D-loop; other site 718219000786 H-loop/switch region; other site 718219000787 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 718219000788 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 718219000789 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 718219000790 IHF - DNA interface [nucleotide binding]; other site 718219000791 IHF dimer interface [polypeptide binding]; other site 718219000792 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 718219000793 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 718219000794 active site 718219000795 metal binding site [ion binding]; metal-binding site 718219000796 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 718219000797 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 718219000798 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718219000799 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 718219000800 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 718219000801 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 718219000802 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 718219000803 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 718219000804 MraW methylase family; Region: Methyltransf_5; pfam01795 718219000805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718219000806 TPR motif; other site 718219000807 binding surface 718219000808 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 718219000809 DnaA N-terminal domain; Region: DnaA_N; pfam11638 718219000810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718219000811 Walker A motif; other site 718219000812 ATP binding site [chemical binding]; other site 718219000813 Walker B motif; other site 718219000814 arginine finger; other site 718219000815 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 718219000816 DnaA box-binding interface [nucleotide binding]; other site 718219000817 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 718219000818 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 718219000819 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 718219000820 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 718219000821 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 718219000822 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 718219000823 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 718219000824 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 718219000825 lipoyl attachment site [posttranslational modification]; other site 718219000826 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 718219000827 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 718219000828 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 718219000829 putative active site [active] 718219000830 catalytic site [active] 718219000831 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 718219000832 putative active site [active] 718219000833 catalytic site [active] 718219000834 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 718219000835 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 718219000836 Clp amino terminal domain; Region: Clp_N; pfam02861 718219000837 Clp amino terminal domain; Region: Clp_N; pfam02861 718219000838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718219000839 Walker A motif; other site 718219000840 ATP binding site [chemical binding]; other site 718219000841 Walker B motif; other site 718219000842 arginine finger; other site 718219000843 UvrB/uvrC motif; Region: UVR; pfam02151 718219000844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718219000845 Walker A motif; other site 718219000846 ATP binding site [chemical binding]; other site 718219000847 Walker B motif; other site 718219000848 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 718219000849 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 718219000850 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 718219000851 Ligand Binding Site [chemical binding]; other site 718219000852 Helix-turn-helix domain; Region: HTH_17; pfam12728 718219000853 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 718219000854 active site 718219000855 phosphorylation site [posttranslational modification] 718219000856 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 718219000857 active site 718219000858 phosphorylation site [posttranslational modification] 718219000859 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 718219000860 trimer interface [polypeptide binding]; other site 718219000861 active site 718219000862 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 718219000863 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 718219000864 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 718219000865 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 718219000866 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 718219000867 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 718219000868 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 718219000869 active site 718219000870 substrate binding site [chemical binding]; other site 718219000871 metal binding site [ion binding]; metal-binding site 718219000872 ribonuclease III; Reviewed; Region: rnc; PRK00102 718219000873 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 718219000874 dimerization interface [polypeptide binding]; other site 718219000875 active site 718219000876 metal binding site [ion binding]; metal-binding site 718219000877 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 718219000878 dsRNA binding site [nucleotide binding]; other site 718219000879 DNA repair protein RadA; Provisional; Region: PRK11823 718219000880 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 718219000881 Walker A motif/ATP binding site; other site 718219000882 ATP binding site [chemical binding]; other site 718219000883 Walker B motif; other site 718219000884 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 718219000885 porphobilinogen deaminase; Provisional; Region: PRK01066 718219000886 Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379 718219000887 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 718219000888 Catalytic domain of Protein Kinases; Region: PKc; cd00180 718219000889 active site 718219000890 ATP binding site [chemical binding]; other site 718219000891 substrate binding site [chemical binding]; other site 718219000892 activation loop (A-loop); other site 718219000893 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 718219000894 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 718219000895 HIGH motif; other site 718219000896 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 718219000897 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 718219000898 active site 718219000899 KMSKS motif; other site 718219000900 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 718219000901 tRNA binding surface [nucleotide binding]; other site 718219000902 anticodon binding site; other site 718219000903 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 718219000904 V-type ATP synthase subunit K; Provisional; Region: PRK09621 718219000905 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 718219000906 V-type ATP synthase subunit I; Validated; Region: PRK05771 718219000907 Protein of unknown function (DUF1319); Region: DUF1319; pfam07028 718219000908 V-type ATP synthase subunit D; Provisional; Region: PRK02195 718219000909 V-type ATP synthase subunit B; Provisional; Region: PRK02118 718219000910 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 718219000911 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 718219000912 Walker A motif homologous position; other site 718219000913 Walker B motif; other site 718219000914 V-type ATP synthase subunit A; Provisional; Region: PRK04192 718219000915 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 718219000916 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 718219000917 Walker A motif/ATP binding site; other site 718219000918 Walker B motif; other site 718219000919 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 718219000920 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 718219000921 V-type ATP synthase subunit E; Provisional; Region: PRK01005 718219000922 V-type ATP synthase subunit E; Provisional; Region: PRK01558 718219000923 transaldolase-like protein; Provisional; Region: PTZ00411 718219000924 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 718219000925 active site 718219000926 dimer interface [polypeptide binding]; other site 718219000927 catalytic residue [active] 718219000928 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 718219000929 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 718219000930 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 718219000931 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 718219000932 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 718219000933 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 718219000934 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 718219000935 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 718219000936 DNA binding site [nucleotide binding] 718219000937 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 718219000938 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 718219000939 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 718219000940 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 718219000941 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 718219000942 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 718219000943 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 718219000944 RPB12 interaction site [polypeptide binding]; other site 718219000945 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 718219000946 RPB3 interaction site [polypeptide binding]; other site 718219000947 RPB1 interaction site [polypeptide binding]; other site 718219000948 RPB11 interaction site [polypeptide binding]; other site 718219000949 RPB10 interaction site [polypeptide binding]; other site 718219000950 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 718219000951 L11 interface [polypeptide binding]; other site 718219000952 putative EF-Tu interaction site [polypeptide binding]; other site 718219000953 putative EF-G interaction site [polypeptide binding]; other site 718219000954 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 718219000955 23S rRNA interface [nucleotide binding]; other site 718219000956 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 718219000957 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 718219000958 mRNA/rRNA interface [nucleotide binding]; other site 718219000959 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 718219000960 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 718219000961 putative thiostrepton binding site; other site 718219000962 23S rRNA interface [nucleotide binding]; other site 718219000963 L7/L12 interface [polypeptide binding]; other site 718219000964 L25 interface [polypeptide binding]; other site 718219000965 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 718219000966 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 718219000967 putative homodimer interface [polypeptide binding]; other site 718219000968 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 718219000969 heterodimer interface [polypeptide binding]; other site 718219000970 homodimer interface [polypeptide binding]; other site 718219000971 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 718219000972 elongation factor Tu; Reviewed; Region: PRK12735 718219000973 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 718219000974 G1 box; other site 718219000975 GEF interaction site [polypeptide binding]; other site 718219000976 GTP/Mg2+ binding site [chemical binding]; other site 718219000977 Switch I region; other site 718219000978 G2 box; other site 718219000979 G3 box; other site 718219000980 Switch II region; other site 718219000981 G4 box; other site 718219000982 G5 box; other site 718219000983 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 718219000984 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 718219000985 Antibiotic Binding Site [chemical binding]; other site 718219000986 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 718219000987 rRNA binding site [nucleotide binding]; other site 718219000988 predicted 30S ribosome binding site; other site 718219000989 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 718219000990 Protein of unknown function (DUF687); Region: DUF687; pfam05095 718219000991 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 718219000992 active site 718219000993 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 718219000994 triosephosphate isomerase; Provisional; Region: PRK14565 718219000995 substrate binding site [chemical binding]; other site 718219000996 dimer interface [polypeptide binding]; other site 718219000997 catalytic triad [active] 718219000998 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 718219000999 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 718219001000 generic binding surface II; other site 718219001001 generic binding surface I; other site 718219001002 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 718219001003 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 718219001004 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 718219001005 TPP-binding site [chemical binding]; other site 718219001006 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 718219001007 PYR/PP interface [polypeptide binding]; other site 718219001008 dimer interface [polypeptide binding]; other site 718219001009 TPP binding site [chemical binding]; other site 718219001010 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 718219001011 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 718219001012 pyruvate kinase; Region: pyruv_kin; TIGR01064 718219001013 domain interfaces; other site 718219001014 active site 718219001015 excinuclease ABC subunit A; Provisional; Region: PRK00635 718219001016 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 718219001017 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 718219001018 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 718219001019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718219001020 Walker A/P-loop; other site 718219001021 ATP binding site [chemical binding]; other site 718219001022 Q-loop/lid; other site 718219001023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718219001024 ABC transporter signature motif; other site 718219001025 Walker B; other site 718219001026 D-loop; other site 718219001027 H-loop/switch region; other site 718219001028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718219001029 Walker A/P-loop; other site 718219001030 ATP binding site [chemical binding]; other site 718219001031 Q-loop/lid; other site 718219001032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718219001033 Q-loop/lid; other site 718219001034 ABC transporter signature motif; other site 718219001035 Walker B; other site 718219001036 D-loop; other site 718219001037 H-loop/switch region; other site 718219001038 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 718219001039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718219001040 Walker A motif; other site 718219001041 ATP binding site [chemical binding]; other site 718219001042 Walker B motif; other site 718219001043 arginine finger; other site 718219001044 hypothetical protein; Validated; Region: PRK00153 718219001045 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 718219001046 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 718219001047 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 718219001048 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 718219001049 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 718219001050 dimerization domain swap beta strand [polypeptide binding]; other site 718219001051 regulatory protein interface [polypeptide binding]; other site 718219001052 active site 718219001053 regulatory phosphorylation site [posttranslational modification]; other site 718219001054 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 718219001055 Competence protein; Region: Competence; pfam03772 718219001056 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 718219001057 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 718219001058 tetramer interface [polypeptide binding]; other site 718219001059 TPP-binding site [chemical binding]; other site 718219001060 heterodimer interface [polypeptide binding]; other site 718219001061 phosphorylation loop region [posttranslational modification] 718219001062 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 718219001063 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 718219001064 alpha subunit interface [polypeptide binding]; other site 718219001065 TPP binding site [chemical binding]; other site 718219001066 heterodimer interface [polypeptide binding]; other site 718219001067 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 718219001068 chaperone protein DnaJ; Provisional; Region: PRK14284 718219001069 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 718219001070 HSP70 interaction site [polypeptide binding]; other site 718219001071 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 718219001072 Zn binding sites [ion binding]; other site 718219001073 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 718219001074 dimer interface [polypeptide binding]; other site 718219001075 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 718219001076 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 718219001077 Glycoprotease family; Region: Peptidase_M22; pfam00814 718219001078 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 718219001079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718219001080 Walker A motif; other site 718219001081 ATP binding site [chemical binding]; other site 718219001082 Walker B motif; other site 718219001083 arginine finger; other site 718219001084 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 718219001085 ribonuclease Z; Region: RNase_Z; TIGR02651 718219001086 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 718219001087 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 718219001088 active site 718219001089 Int/Topo IB signature motif; other site 718219001090 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 718219001091 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718219001092 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718219001093 ABC transporter; Region: ABC_tran_2; pfam12848 718219001094 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718219001095 Maf-like protein; Region: Maf; pfam02545 718219001096 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 718219001097 active site 718219001098 dimer interface [polypeptide binding]; other site 718219001099 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 718219001100 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 718219001101 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 718219001102 active site 718219001103 catalytic residues [active] 718219001104 metal binding site [ion binding]; metal-binding site 718219001105 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 718219001106 dimethyladenosine transferase; Region: ksgA; TIGR00755 718219001107 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 718219001108 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 718219001109 catalytic residues [active] 718219001110 potential protein location (hypothetical protein CTG9301_01835 [Chlamydia trachomatis G/9301]) that overlaps RNA (tRNA-S) 718219001111 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 718219001112 dihydrodipicolinate synthase; Region: dapA; TIGR00674 718219001113 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 718219001114 inhibitor site; inhibition site 718219001115 active site 718219001116 dimer interface [polypeptide binding]; other site 718219001117 catalytic residue [active] 718219001118 aspartate kinase; Provisional; Region: PRK05925 718219001119 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 718219001120 putative catalytic residues [active] 718219001121 nucleotide binding site [chemical binding]; other site 718219001122 aspartate binding site [chemical binding]; other site 718219001123 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 718219001124 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 718219001125 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 718219001126 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 718219001127 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 718219001128 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 718219001129 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 718219001130 hinge; other site 718219001131 active site 718219001132 shikimate kinase; Provisional; Region: PRK00625 718219001133 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 718219001134 ADP binding site [chemical binding]; other site 718219001135 magnesium binding site [ion binding]; other site 718219001136 putative shikimate binding site; other site 718219001137 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 718219001138 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 718219001139 Tetramer interface [polypeptide binding]; other site 718219001140 active site 718219001141 FMN-binding site [chemical binding]; other site 718219001142 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 718219001143 active site 718219001144 dimer interface [polypeptide binding]; other site 718219001145 metal binding site [ion binding]; metal-binding site 718219001146 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 718219001147 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 718219001148 active site 718219001149 catalytic residue [active] 718219001150 dimer interface [polypeptide binding]; other site 718219001151 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 718219001152 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 718219001153 shikimate binding site; other site 718219001154 NAD(P) binding site [chemical binding]; other site 718219001155 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 718219001156 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 718219001157 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 718219001158 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 718219001159 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 718219001160 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 718219001161 malate dehydrogenase; Provisional; Region: PRK05442 718219001162 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 718219001163 NAD(P) binding site [chemical binding]; other site 718219001164 dimer interface [polypeptide binding]; other site 718219001165 malate binding site [chemical binding]; other site 718219001166 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 718219001167 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 718219001168 active site 718219001169 dimer interface [polypeptide binding]; other site 718219001170 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 718219001171 dimer interface [polypeptide binding]; other site 718219001172 active site 718219001173 GTPases [General function prediction only]; Region: HflX; COG2262 718219001174 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 718219001175 HflX GTPase family; Region: HflX; cd01878 718219001176 G1 box; other site 718219001177 GTP/Mg2+ binding site [chemical binding]; other site 718219001178 Switch I region; other site 718219001179 G2 box; other site 718219001180 G3 box; other site 718219001181 Switch II region; other site 718219001182 G4 box; other site 718219001183 G5 box; other site 718219001184 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 718219001185 putative hydrolase; Provisional; Region: PRK02113 718219001186 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 718219001187 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718219001188 substrate binding pocket [chemical binding]; other site 718219001189 membrane-bound complex binding site; other site 718219001190 hinge residues; other site 718219001191 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 718219001192 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 718219001193 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 718219001194 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 718219001195 nucleotide binding site/active site [active] 718219001196 Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286 718219001197 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 718219001198 hypothetical protein; Validated; Region: PRK00647 718219001199 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 718219001200 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 718219001201 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718219001202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718219001203 homodimer interface [polypeptide binding]; other site 718219001204 catalytic residue [active] 718219001205 ABC transporter substrate binding protein; Region: ABC_sub_bind; pfam04392 718219001206 prolyl-tRNA synthetase; Provisional; Region: PRK09194 718219001207 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 718219001208 dimer interface [polypeptide binding]; other site 718219001209 motif 1; other site 718219001210 active site 718219001211 motif 2; other site 718219001212 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 718219001213 putative deacylase active site [active] 718219001214 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 718219001215 active site 718219001216 motif 3; other site 718219001217 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 718219001218 anticodon binding site; other site 718219001219 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 718219001220 GrpE; Region: GrpE; pfam01025 718219001221 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 718219001222 dimer interface [polypeptide binding]; other site 718219001223 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 718219001224 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 718219001225 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 718219001226 nucleotide binding site [chemical binding]; other site 718219001227 NEF interaction site [polypeptide binding]; other site 718219001228 SBD interface [polypeptide binding]; other site 718219001229 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 718219001230 Exoribonuclease R [Transcription]; Region: VacB; COG0557 718219001231 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 718219001232 RNB domain; Region: RNB; pfam00773 718219001233 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 718219001234 Putative zinc ribbon domain; Region: DUF164; pfam02591 718219001235 KpsF/GutQ family protein; Region: kpsF; TIGR00393 718219001236 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 718219001237 putative active site [active] 718219001238 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 718219001239 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 718219001240 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 718219001241 E3 interaction surface; other site 718219001242 lipoyl attachment site [posttranslational modification]; other site 718219001243 e3 binding domain; Region: E3_binding; pfam02817 718219001244 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 718219001245 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 718219001246 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 718219001247 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 718219001248 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 718219001249 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 718219001250 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 718219001251 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 718219001252 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 718219001253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718219001254 S-adenosylmethionine binding site [chemical binding]; other site 718219001255 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 718219001256 Lumazine binding domain; Region: Lum_binding; pfam00677 718219001257 Lumazine binding domain; Region: Lum_binding; pfam00677 718219001258 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 718219001259 ATP cone domain; Region: ATP-cone; pfam03477 718219001260 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 718219001261 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 718219001262 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 718219001263 amino acid carrier protein; Region: agcS; TIGR00835 718219001264 poly(A) polymerase; Region: pcnB; TIGR01942 718219001265 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 718219001266 active site 718219001267 NTP binding site [chemical binding]; other site 718219001268 metal binding triad [ion binding]; metal-binding site 718219001269 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 718219001270 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 718219001271 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 718219001272 Predicted membrane protein [Function unknown]; Region: COG3952 718219001273 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 718219001274 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 718219001275 Autotransporter beta-domain; Region: Autotransporter; pfam03797 718219001276 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 718219001277 Autotransporter beta-domain; Region: Autotransporter; pfam03797 718219001278 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 718219001279 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 718219001280 Autotransporter beta-domain; Region: Autotransporter; pfam03797 718219001281 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 718219001282 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 718219001283 intersubunit interface [polypeptide binding]; other site 718219001284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718219001285 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 718219001286 Walker A/P-loop; other site 718219001287 ATP binding site [chemical binding]; other site 718219001288 Q-loop/lid; other site 718219001289 ABC transporter signature motif; other site 718219001290 Walker B; other site 718219001291 D-loop; other site 718219001292 H-loop/switch region; other site 718219001293 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 718219001294 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718219001295 ABC-ATPase subunit interface; other site 718219001296 dimer interface [polypeptide binding]; other site 718219001297 putative PBP binding regions; other site 718219001298 GTPase CgtA; Reviewed; Region: obgE; PRK12299 718219001299 GTP1/OBG; Region: GTP1_OBG; pfam01018 718219001300 Obg GTPase; Region: Obg; cd01898 718219001301 G1 box; other site 718219001302 GTP/Mg2+ binding site [chemical binding]; other site 718219001303 Switch I region; other site 718219001304 G2 box; other site 718219001305 G3 box; other site 718219001306 Switch II region; other site 718219001307 G4 box; other site 718219001308 G5 box; other site 718219001309 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 718219001310 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 718219001311 Uncharacterized conserved protein [Function unknown]; Region: COG2928 718219001312 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 718219001313 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 718219001314 FOG: CBS domain [General function prediction only]; Region: COG0517 718219001315 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 718219001316 Transporter associated domain; Region: CorC_HlyC; smart01091 718219001317 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 718219001318 anti sigma factor interaction site; other site 718219001319 regulatory phosphorylation site [posttranslational modification]; other site 718219001320 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 718219001321 hypothetical protein; Provisional; Region: PRK05926 718219001322 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718219001323 FeS/SAM binding site; other site 718219001324 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 718219001325 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 718219001326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718219001327 S-adenosylmethionine binding site [chemical binding]; other site 718219001328 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 718219001329 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 718219001330 diaminopimelate epimerase; Region: DapF; TIGR00652 718219001331 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 718219001332 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 718219001333 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 718219001334 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 718219001335 oligomer interface [polypeptide binding]; other site 718219001336 active site residues [active] 718219001337 serine hydroxymethyltransferase; Provisional; Region: PRK13580 718219001338 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 718219001339 dimer interface [polypeptide binding]; other site 718219001340 active site 718219001341 glycine-pyridoxal phosphate binding site [chemical binding]; other site 718219001342 folate binding site [chemical binding]; other site 718219001343 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 718219001344 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 718219001345 active site 718219001346 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 718219001347 homotrimer interaction site [polypeptide binding]; other site 718219001348 zinc binding site [ion binding]; other site 718219001349 CDP-binding sites; other site 718219001350 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 718219001351 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 718219001352 FAD binding pocket [chemical binding]; other site 718219001353 conserved FAD binding motif [chemical binding]; other site 718219001354 phosphate binding motif [ion binding]; other site 718219001355 beta-alpha-beta structure motif; other site 718219001356 NAD binding pocket [chemical binding]; other site 718219001357 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 718219001358 elongation factor G; Reviewed; Region: PRK12739 718219001359 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 718219001360 G1 box; other site 718219001361 putative GEF interaction site [polypeptide binding]; other site 718219001362 GTP/Mg2+ binding site [chemical binding]; other site 718219001363 Switch I region; other site 718219001364 G2 box; other site 718219001365 G3 box; other site 718219001366 Switch II region; other site 718219001367 G4 box; other site 718219001368 G5 box; other site 718219001369 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 718219001370 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 718219001371 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 718219001372 30S ribosomal protein S7; Validated; Region: PRK05302 718219001373 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 718219001374 S17 interaction site [polypeptide binding]; other site 718219001375 S8 interaction site; other site 718219001376 16S rRNA interaction site [nucleotide binding]; other site 718219001377 streptomycin interaction site [chemical binding]; other site 718219001378 23S rRNA interaction site [nucleotide binding]; other site 718219001379 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 718219001380 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 718219001381 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 718219001382 protein binding site [polypeptide binding]; other site 718219001383 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 718219001384 Catalytic dyad [active] 718219001385 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 718219001386 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 718219001387 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 718219001388 Domain of unknown function DUF11; Region: DUF11; pfam01345 718219001389 Domain of unknown function DUF11; Region: DUF11; pfam01345 718219001390 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 718219001391 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 718219001392 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 718219001393 HIGH motif; other site 718219001394 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 718219001395 active site 718219001396 KMSKS motif; other site 718219001397 Helix-turn-helix domain; Region: HTH_17; pfam12728 718219001398 Helix-turn-helix domain; Region: HTH_17; cl17695 718219001399 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 718219001400 DHH family; Region: DHH; pfam01368 718219001401 DHHA1 domain; Region: DHHA1; pfam02272 718219001402 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 718219001403 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 718219001404 Protein export membrane protein; Region: SecD_SecF; pfam02355 718219001405 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 718219001406 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 718219001407 catalytic residue [active] 718219001408 putative FPP diphosphate binding site; other site 718219001409 putative FPP binding hydrophobic cleft; other site 718219001410 dimer interface [polypeptide binding]; other site 718219001411 putative IPP diphosphate binding site; other site 718219001412 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 718219001413 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 718219001414 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 718219001415 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 718219001416 CMP-binding site; other site 718219001417 The sites determining sugar specificity; other site 718219001418 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 718219001419 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 718219001420 putative acyl-acceptor binding pocket; other site 718219001421 arginine-tRNA ligase; Region: PLN02286 718219001422 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 718219001423 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 718219001424 active site 718219001425 HIGH motif; other site 718219001426 KMSK motif region; other site 718219001427 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 718219001428 tRNA binding surface [nucleotide binding]; other site 718219001429 anticodon binding site; other site 718219001430 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 718219001431 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 718219001432 hinge; other site 718219001433 active site 718219001434 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 718219001435 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 718219001436 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 718219001437 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 718219001438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718219001439 Coenzyme A binding pocket [chemical binding]; other site 718219001440 PCRF domain; Region: PCRF; pfam03462 718219001441 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 718219001442 RF-1 domain; Region: RF-1; pfam00472 718219001443 SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531 718219001444 SWI complex, BAF60b domains; Region: SWIB; smart00151 718219001445 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 718219001446 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 718219001447 putative active site [active] 718219001448 putative metal binding site [ion binding]; other site 718219001449 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 718219001450 substrate binding site; other site 718219001451 dimer interface; other site 718219001452 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 718219001453 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 718219001454 dimerization interface 3.5A [polypeptide binding]; other site 718219001455 active site 718219001456 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 718219001457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718219001458 active site 718219001459 motif I; other site 718219001460 motif II; other site 718219001461 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 718219001462 PAS domain; Region: PAS; smart00091 718219001463 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718219001464 dimer interface [polypeptide binding]; other site 718219001465 phosphorylation site [posttranslational modification] 718219001466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718219001467 ATP binding site [chemical binding]; other site 718219001468 Mg2+ binding site [ion binding]; other site 718219001469 G-X-G motif; other site 718219001470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718219001471 Response regulator receiver domain; Region: Response_reg; pfam00072 718219001472 active site 718219001473 phosphorylation site [posttranslational modification] 718219001474 intermolecular recognition site; other site 718219001475 dimerization interface [polypeptide binding]; other site 718219001476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718219001477 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 718219001478 Walker A motif; other site 718219001479 ATP binding site [chemical binding]; other site 718219001480 Walker B motif; other site 718219001481 arginine finger; other site 718219001482 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 718219001483 Recombination protein O N terminal; Region: RecO_N; pfam11967 718219001484 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 718219001485 Recombination protein O C terminal; Region: RecO_C; pfam02565 718219001486 potential protein location (hypothetical protein CTG9301_02470 [Chlamydia trachomatis G/9301]) that overlaps RNA (tRNA-L) 718219001487 Uncharacterized conserved protein [Function unknown]; Region: COG1723 718219001488 hypothetical protein; Provisional; Region: PRK14377 718219001489 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 718219001490 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 718219001491 putative tRNA-binding site [nucleotide binding]; other site 718219001492 B3/4 domain; Region: B3_4; pfam03483 718219001493 tRNA synthetase B5 domain; Region: B5; smart00874 718219001494 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 718219001495 dimer interface [polypeptide binding]; other site 718219001496 motif 1; other site 718219001497 motif 3; other site 718219001498 motif 2; other site 718219001499 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 718219001500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 718219001501 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 718219001502 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 718219001503 DNA binding site [nucleotide binding] 718219001504 active site 718219001505 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 718219001506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718219001507 dimer interface [polypeptide binding]; other site 718219001508 conserved gate region; other site 718219001509 putative PBP binding loops; other site 718219001510 ABC-ATPase subunit interface; other site 718219001511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 718219001512 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 718219001513 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 718219001514 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 718219001515 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 718219001516 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 718219001517 putative active site [active] 718219001518 putative metal binding site [ion binding]; other site 718219001519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718219001520 binding surface 718219001521 TPR motif; other site 718219001522 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 718219001523 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 718219001524 C-terminal domain interface [polypeptide binding]; other site 718219001525 active site 718219001526 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 718219001527 active site 718219001528 N-terminal domain interface [polypeptide binding]; other site 718219001529 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 718219001530 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718219001531 substrate binding pocket [chemical binding]; other site 718219001532 membrane-bound complex binding site; other site 718219001533 hinge residues; other site 718219001534 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 718219001535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718219001536 S-adenosylmethionine binding site [chemical binding]; other site 718219001537 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 718219001538 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 718219001539 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 718219001540 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 718219001541 ligand binding site; other site 718219001542 oligomer interface; other site 718219001543 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 718219001544 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 718219001545 N-terminal domain interface [polypeptide binding]; other site 718219001546 sulfate 1 binding site; other site 718219001547 transcription termination factor Rho; Region: rho; TIGR00767 718219001548 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 718219001549 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 718219001550 RNA binding site [nucleotide binding]; other site 718219001551 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 718219001552 multimer interface [polypeptide binding]; other site 718219001553 Walker A motif; other site 718219001554 ATP binding site [chemical binding]; other site 718219001555 Walker B motif; other site 718219001556 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 718219001557 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 718219001558 CoA-binding site [chemical binding]; other site 718219001559 ATP-binding [chemical binding]; other site 718219001560 DNA polymerase I; Provisional; Region: PRK05755 718219001561 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 718219001562 active site 718219001563 metal binding site 1 [ion binding]; metal-binding site 718219001564 putative 5' ssDNA interaction site; other site 718219001565 metal binding site 3; metal-binding site 718219001566 metal binding site 2 [ion binding]; metal-binding site 718219001567 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 718219001568 putative DNA binding site [nucleotide binding]; other site 718219001569 putative metal binding site [ion binding]; other site 718219001570 3'-5' exonuclease; Region: 35EXOc; smart00474 718219001571 active site 718219001572 substrate binding site [chemical binding]; other site 718219001573 catalytic site [active] 718219001574 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 718219001575 active site 718219001576 DNA binding site [nucleotide binding] 718219001577 catalytic site [active] 718219001578 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 718219001579 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 718219001580 tandem repeat interface [polypeptide binding]; other site 718219001581 oligomer interface [polypeptide binding]; other site 718219001582 active site residues [active] 718219001583 TLC ATP/ADP transporter; Region: TLC; pfam03219 718219001584 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 718219001585 replicative DNA helicase; Provisional; Region: PRK06321 718219001586 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 718219001587 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 718219001588 Walker A motif; other site 718219001589 ATP binding site [chemical binding]; other site 718219001590 Walker B motif; other site 718219001591 DNA binding loops [nucleotide binding] 718219001592 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 718219001593 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 718219001594 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 718219001595 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 718219001596 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 718219001597 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 718219001598 active site 718219001599 multimer interface [polypeptide binding]; other site 718219001600 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 718219001601 RuvA N terminal domain; Region: RuvA_N; pfam01330 718219001602 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 718219001603 active site 718219001604 putative DNA-binding cleft [nucleotide binding]; other site 718219001605 dimer interface [polypeptide binding]; other site 718219001606 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 718219001607 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 718219001608 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 718219001609 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 718219001610 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 718219001611 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 718219001612 alphaNTD - beta interaction site [polypeptide binding]; other site 718219001613 alphaNTD homodimer interface [polypeptide binding]; other site 718219001614 alphaNTD - beta' interaction site [polypeptide binding]; other site 718219001615 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 718219001616 30S ribosomal protein S11; Validated; Region: PRK05309 718219001617 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 718219001618 30S ribosomal protein S13; Region: bact_S13; TIGR03631 718219001619 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 718219001620 SecY translocase; Region: SecY; pfam00344 718219001621 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 718219001622 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 718219001623 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 718219001624 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 718219001625 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 718219001626 5S rRNA interface [nucleotide binding]; other site 718219001627 23S rRNA interface [nucleotide binding]; other site 718219001628 L5 interface [polypeptide binding]; other site 718219001629 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 718219001630 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 718219001631 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 718219001632 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 718219001633 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 718219001634 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 718219001635 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 718219001636 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 718219001637 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 718219001638 RNA binding site [nucleotide binding]; other site 718219001639 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 718219001640 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 718219001641 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 718219001642 23S rRNA interface [nucleotide binding]; other site 718219001643 putative translocon interaction site; other site 718219001644 signal recognition particle (SRP54) interaction site; other site 718219001645 L23 interface [polypeptide binding]; other site 718219001646 trigger factor interaction site; other site 718219001647 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 718219001648 23S rRNA interface [nucleotide binding]; other site 718219001649 5S rRNA interface [nucleotide binding]; other site 718219001650 putative antibiotic binding site [chemical binding]; other site 718219001651 L25 interface [polypeptide binding]; other site 718219001652 L27 interface [polypeptide binding]; other site 718219001653 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 718219001654 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 718219001655 G-X-X-G motif; other site 718219001656 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 718219001657 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 718219001658 putative translocon binding site; other site 718219001659 protein-rRNA interface [nucleotide binding]; other site 718219001660 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 718219001661 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 718219001662 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 718219001663 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 718219001664 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 718219001665 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 718219001666 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 718219001667 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 718219001668 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 718219001669 putative active site [active] 718219001670 substrate binding site [chemical binding]; other site 718219001671 putative cosubstrate binding site; other site 718219001672 catalytic site [active] 718219001673 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 718219001674 substrate binding site [chemical binding]; other site 718219001675 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 718219001676 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 718219001677 active site 718219001678 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 718219001679 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 718219001680 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 718219001681 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 718219001682 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 718219001683 putative active site [active] 718219001684 catalytic triad [active] 718219001685 putative dimer interface [polypeptide binding]; other site 718219001686 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 718219001687 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 718219001688 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 718219001689 active site 718219001690 catalytic site [active] 718219001691 substrate binding site [chemical binding]; other site 718219001692 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 718219001693 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 718219001694 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 718219001695 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 718219001696 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 718219001697 catalytic residues [active] 718219001698 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 718219001699 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 718219001700 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 718219001701 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 718219001702 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 718219001703 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 718219001704 dimer interface [polypeptide binding]; other site 718219001705 anticodon binding site; other site 718219001706 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 718219001707 homodimer interface [polypeptide binding]; other site 718219001708 motif 1; other site 718219001709 active site 718219001710 motif 2; other site 718219001711 GAD domain; Region: GAD; pfam02938 718219001712 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 718219001713 active site 718219001714 motif 3; other site 718219001715 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 718219001716 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 718219001717 dimer interface [polypeptide binding]; other site 718219001718 motif 1; other site 718219001719 active site 718219001720 motif 2; other site 718219001721 motif 3; other site 718219001722 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 718219001723 anticodon binding site; other site 718219001724 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 718219001725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718219001726 putative substrate translocation pore; other site 718219001727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718219001728 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 718219001729 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 718219001730 active site 718219001731 PHP Thumb interface [polypeptide binding]; other site 718219001732 metal binding site [ion binding]; metal-binding site 718219001733 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 718219001734 generic binding surface I; other site 718219001735 generic binding surface II; other site 718219001736 TPR repeat; Region: TPR_11; pfam13414 718219001737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 718219001738 binding surface 718219001739 TPR motif; other site 718219001740 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 718219001741 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 718219001742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 718219001743 Mg2+ binding site [ion binding]; other site 718219001744 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 718219001745 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 718219001746 potential frameshift: common BLAST hit: gi|237804904|ref|YP_002889058.1| putative methyltransferase 718219001747 branched-chain amino acid uptake carrier; Region: livcs; TIGR00796 718219001748 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 718219001749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718219001750 ATP binding site [chemical binding]; other site 718219001751 putative Mg++ binding site [ion binding]; other site 718219001752 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718219001753 nucleotide binding region [chemical binding]; other site 718219001754 ATP-binding site [chemical binding]; other site 718219001755 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 718219001756 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 718219001757 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718219001758 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 718219001759 lipoate synthase; Region: lipA; TIGR00510 718219001760 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718219001761 FeS/SAM binding site; other site 718219001762 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 718219001763 type III secretion system protein; Validated; Region: PRK06328 718219001764 Flagellar assembly protein FliH; Region: FliH; pfam02108 718219001765 type III secretion system protein; Reviewed; Region: PRK09617 718219001766 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 718219001767 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 718219001768 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 718219001769 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 718219001770 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 718219001771 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 718219001772 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 718219001773 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 718219001774 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 718219001775 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 718219001776 Walker A motif; other site 718219001777 ATP binding site [chemical binding]; other site 718219001778 Walker B motif; other site 718219001779 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 718219001780 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 718219001781 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 718219001782 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 718219001783 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 718219001784 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 718219001785 active site 718219001786 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 718219001787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718219001788 ATP binding site [chemical binding]; other site 718219001789 Mg2+ binding site [ion binding]; other site 718219001790 G-X-G motif; other site 718219001791 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 718219001792 ATP binding site [chemical binding]; other site 718219001793 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 718219001794 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 718219001795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718219001796 binding surface 718219001797 TPR motif; other site 718219001798 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 718219001799 EamA-like transporter family; Region: EamA; pfam00892 718219001800 EamA-like transporter family; Region: EamA; pfam00892 718219001801 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 718219001802 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cd01616 718219001803 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 718219001804 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 718219001805 active site 718219001806 dimer interface [polypeptide binding]; other site 718219001807 motif 1; other site 718219001808 motif 2; other site 718219001809 motif 3; other site 718219001810 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 718219001811 anticodon binding site; other site 718219001812 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 718219001813 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718219001814 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 718219001815 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 718219001816 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 718219001817 active site 718219001818 HIGH motif; other site 718219001819 dimer interface [polypeptide binding]; other site 718219001820 KMSKS motif; other site 718219001821 excinuclease ABC subunit B; Provisional; Region: PRK05298 718219001822 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718219001823 ATP binding site [chemical binding]; other site 718219001824 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718219001825 nucleotide binding region [chemical binding]; other site 718219001826 ATP-binding site [chemical binding]; other site 718219001827 Ultra-violet resistance protein B; Region: UvrB; pfam12344 718219001828 enolase; Provisional; Region: eno; PRK00077 718219001829 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 718219001830 dimer interface [polypeptide binding]; other site 718219001831 metal binding site [ion binding]; metal-binding site 718219001832 substrate binding pocket [chemical binding]; other site 718219001833 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 718219001834 HAMP domain; Region: HAMP; pfam00672 718219001835 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 718219001836 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 718219001837 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 718219001838 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 718219001839 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 718219001840 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 718219001841 L-aspartate oxidase; Provisional; Region: PRK06175 718219001842 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 718219001843 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 718219001844 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 718219001845 proximal heme binding site [chemical binding]; other site 718219001846 Iron-sulfur protein interface; other site 718219001847 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 718219001848 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 718219001849 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 718219001850 active site 718219001851 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 718219001852 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 718219001853 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 718219001854 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 718219001855 DsbD alpha interface [polypeptide binding]; other site 718219001856 catalytic residues [active] 718219001857 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 718219001858 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 718219001859 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 718219001860 translocation protein TolB; Provisional; Region: tolB; PRK01029 718219001861 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 718219001862 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 718219001863 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 718219001864 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 718219001865 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 718219001866 ligand binding site [chemical binding]; other site 718219001867 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 718219001868 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 718219001869 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 718219001870 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 718219001871 dimer interface [polypeptide binding]; other site 718219001872 decamer (pentamer of dimers) interface [polypeptide binding]; other site 718219001873 catalytic triad [active] 718219001874 peroxidatic and resolving cysteines [active] 718219001875 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 718219001876 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 718219001877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 718219001878 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 718219001879 active site 718219001880 dimerization interface [polypeptide binding]; other site 718219001881 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 718219001882 ligand binding site [chemical binding]; other site 718219001883 active site 718219001884 UGI interface [polypeptide binding]; other site 718219001885 catalytic site [active] 718219001886 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 718219001887 Part of AAA domain; Region: AAA_19; pfam13245 718219001888 Family description; Region: UvrD_C_2; pfam13538 718219001889 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 718219001890 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 718219001891 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 718219001892 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 718219001893 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 718219001894 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 718219001895 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 718219001896 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 718219001897 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 718219001898 folate binding site [chemical binding]; other site 718219001899 NADP+ binding site [chemical binding]; other site 718219001900 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 718219001901 catalytic center binding site [active] 718219001902 ATP binding site [chemical binding]; other site 718219001903 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 718219001904 dihydropteroate synthase; Region: DHPS; TIGR01496 718219001905 substrate binding pocket [chemical binding]; other site 718219001906 dimer interface [polypeptide binding]; other site 718219001907 inhibitor binding site; inhibition site 718219001908 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 718219001909 homooctamer interface [polypeptide binding]; other site 718219001910 active site 718219001911 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 718219001912 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 718219001913 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 718219001914 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 718219001915 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 718219001916 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 718219001917 DNA binding residues [nucleotide binding] 718219001918 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 718219001919 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 718219001920 Effector from type III secretion system; Region: Effector_1; pfam04518 718219001921 Effector from type III secretion system; Region: Effector_1; pfam04518 718219001922 Effector from type III secretion system; Region: Effector_1; pfam04518 718219001923 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 718219001924 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 718219001925 MviN-like protein; Region: MVIN; pfam03023 718219001926 endonuclease IV; Provisional; Region: PRK01060 718219001927 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 718219001928 AP (apurinic/apyrimidinic) site pocket; other site 718219001929 DNA interaction; other site 718219001930 Metal-binding active site; metal-binding site 718219001931 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 718219001932 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 718219001933 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718219001934 RNA binding surface [nucleotide binding]; other site 718219001935 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 718219001936 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 718219001937 active site residue [active] 718219001938 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 718219001939 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 718219001940 substrate binding pocket [chemical binding]; other site 718219001941 chain length determination region; other site 718219001942 substrate-Mg2+ binding site; other site 718219001943 catalytic residues [active] 718219001944 aspartate-rich region 1; other site 718219001945 active site lid residues [active] 718219001946 aspartate-rich region 2; other site 718219001947 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 718219001948 putative trimer interface [polypeptide binding]; other site 718219001949 putative CoA binding site [chemical binding]; other site 718219001950 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 718219001951 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718219001952 DNA binding site [nucleotide binding] 718219001953 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 718219001954 Thymidylate synthase complementing protein; Region: Thy1; cl03630 718219001955 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 718219001956 dimer interface [polypeptide binding]; other site 718219001957 active site 718219001958 aspartate-rich active site metal binding site; other site 718219001959 allosteric magnesium binding site [ion binding]; other site 718219001960 Schiff base residues; other site 718219001961 NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit; Region: nqrA; TIGR01936 718219001962 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 718219001963 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 718219001964 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 718219001965 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 718219001966 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 718219001967 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718219001968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718219001969 homodimer interface [polypeptide binding]; other site 718219001970 catalytic residue [active] 718219001971 rod shape-determining protein MreC; Provisional; Region: PRK14872 718219001972 rod shape-determining protein MreC; Region: MreC; pfam04085 718219001973 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 718219001974 Part of AAA domain; Region: AAA_19; pfam13245 718219001975 Family description; Region: UvrD_C_2; pfam13538 718219001976 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 718219001977 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718219001978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718219001979 putative substrate translocation pore; other site 718219001980 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 718219001981 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 718219001982 active site 718219001983 interdomain interaction site; other site 718219001984 putative metal-binding site [ion binding]; other site 718219001985 nucleotide binding site [chemical binding]; other site 718219001986 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 718219001987 domain I; other site 718219001988 DNA binding groove [nucleotide binding] 718219001989 phosphate binding site [ion binding]; other site 718219001990 domain II; other site 718219001991 domain III; other site 718219001992 nucleotide binding site [chemical binding]; other site 718219001993 catalytic site [active] 718219001994 domain IV; other site 718219001995 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 718219001996 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 718219001997 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 718219001998 SWI complex, BAF60b domains; Region: SWIB; smart00151 718219001999 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 718219002000 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 718219002001 FMN binding site [chemical binding]; other site 718219002002 active site 718219002003 catalytic residues [active] 718219002004 substrate binding site [chemical binding]; other site 718219002005 Predicted integral membrane protein [Function unknown]; Region: COG0762 718219002006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 718219002007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 718219002008 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 718219002009 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 718219002010 recombinase A; Provisional; Region: recA; PRK09354 718219002011 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 718219002012 hexamer interface [polypeptide binding]; other site 718219002013 Walker A motif; other site 718219002014 ATP binding site [chemical binding]; other site 718219002015 Walker B motif; other site 718219002016 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 718219002017 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 718219002018 AAA domain; Region: AAA_30; pfam13604 718219002019 Family description; Region: UvrD_C_2; pfam13538 718219002020 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 718219002021 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 718219002022 Walker A/P-loop; other site 718219002023 ATP binding site [chemical binding]; other site 718219002024 Q-loop/lid; other site 718219002025 ABC transporter signature motif; other site 718219002026 Walker B; other site 718219002027 D-loop; other site 718219002028 H-loop/switch region; other site 718219002029 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 718219002030 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 718219002031 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 718219002032 potential protein location (hypothetical protein CTG9301_03470 [Chlamydia trachomatis G/9301]) that overlaps RNA (tRNA-R) 718219002033 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 718219002034 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718219002035 RNA binding surface [nucleotide binding]; other site 718219002036 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 718219002037 active site 718219002038 hypothetical protein; Provisional; Region: PRK01064 718219002039 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 718219002040 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 718219002041 DNA Topoisomerase IV; Region: TOP4c; smart00434 718219002042 CAP-like domain; other site 718219002043 active site 718219002044 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 718219002045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718219002046 ATP binding site [chemical binding]; other site 718219002047 Mg2+ binding site [ion binding]; other site 718219002048 G-X-G motif; other site 718219002049 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 718219002050 ATP binding site [chemical binding]; other site 718219002051 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 718219002052 active site 718219002053 putative metal-binding site [ion binding]; other site 718219002054 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 718219002055 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 718219002056 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 718219002057 NAD(P) binding pocket [chemical binding]; other site 718219002058 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 718219002059 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 718219002060 phosphopeptide binding site; other site 718219002061 MARCKS family; Region: MARCKS; pfam02063 718219002062 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 718219002063 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 718219002064 phosphopeptide binding site; other site 718219002065 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 718219002066 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 718219002067 binding surface 718219002068 Tetratricopeptide repeat; Region: TPR_16; pfam13432 718219002069 TPR motif; other site 718219002070 type III secretion system ATPase; Provisional; Region: PRK06315 718219002071 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 718219002072 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 718219002073 Walker A motif/ATP binding site; other site 718219002074 Walker B motif; other site 718219002075 type III secretion system protein; Validated; Region: PRK05933 718219002076 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 718219002077 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 718219002078 Catalytic domain of Protein Kinases; Region: PKc; cd00180 718219002079 active site 718219002080 ATP binding site [chemical binding]; other site 718219002081 substrate binding site [chemical binding]; other site 718219002082 activation loop (A-loop); other site 718219002083 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 718219002084 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 718219002085 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 718219002086 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 718219002087 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 718219002088 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 718219002089 ADP binding site [chemical binding]; other site 718219002090 phosphagen binding site; other site 718219002091 substrate specificity loop; other site 718219002092 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 718219002093 UvrB/uvrC motif; Region: UVR; pfam02151 718219002094 ribosome recycling factor; Reviewed; Region: frr; PRK00083 718219002095 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 718219002096 hinge region; other site 718219002097 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 718219002098 putative nucleotide binding site [chemical binding]; other site 718219002099 uridine monophosphate binding site [chemical binding]; other site 718219002100 homohexameric interface [polypeptide binding]; other site 718219002101 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 718219002102 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 718219002103 Elongation factor TS; Region: EF_TS; pfam00889 718219002104 Elongation factor TS; Region: EF_TS; pfam00889 718219002105 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 718219002106 rRNA interaction site [nucleotide binding]; other site 718219002107 S8 interaction site; other site 718219002108 putative laminin-1 binding site; other site 718219002109 potential protein location (hypothetical protein CTG9301_03605 [Chlamydia trachomatis G/9301]) that overlaps RNA (tRNA-G) 718219002110 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 718219002111 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 718219002112 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 718219002113 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 718219002114 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 718219002115 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718219002116 TPR motif; other site 718219002117 Tetratricopeptide repeat; Region: TPR_16; pfam13432 718219002118 binding surface 718219002119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718219002120 binding surface 718219002121 TPR motif; other site 718219002122 TPR repeat; Region: TPR_11; pfam13414 718219002123 TPR repeat; Region: TPR_11; pfam13414 718219002124 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718219002125 binding surface 718219002126 TPR motif; other site 718219002127 TPR repeat; Region: TPR_11; pfam13414 718219002128 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 718219002129 putative ABC transporter; Region: ycf24; CHL00085 718219002130 FeS assembly ATPase SufC; Region: sufC; TIGR01978 718219002131 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 718219002132 Walker A/P-loop; other site 718219002133 ATP binding site [chemical binding]; other site 718219002134 Q-loop/lid; other site 718219002135 ABC transporter signature motif; other site 718219002136 Walker B; other site 718219002137 D-loop; other site 718219002138 H-loop/switch region; other site 718219002139 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 718219002140 FeS assembly protein SufD; Region: sufD; TIGR01981 718219002141 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 718219002142 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 718219002143 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718219002144 catalytic residue [active] 718219002145 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 718219002146 ParB-like nuclease domain; Region: ParBc; pfam02195 718219002147 KorB domain; Region: KorB; pfam08535 718219002148 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718219002149 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 718219002150 Walker A/P-loop; other site 718219002151 ATP binding site [chemical binding]; other site 718219002152 Q-loop/lid; other site 718219002153 ABC transporter signature motif; other site 718219002154 Walker B; other site 718219002155 D-loop; other site 718219002156 H-loop/switch region; other site 718219002157 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 718219002158 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 718219002159 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718219002160 Walker A/P-loop; other site 718219002161 ATP binding site [chemical binding]; other site 718219002162 Q-loop/lid; other site 718219002163 ABC transporter signature motif; other site 718219002164 Walker B; other site 718219002165 D-loop; other site 718219002166 H-loop/switch region; other site 718219002167 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 718219002168 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 718219002169 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 718219002170 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 718219002171 Phosphoglycerate kinase; Region: PGK; pfam00162 718219002172 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 718219002173 substrate binding site [chemical binding]; other site 718219002174 hinge regions; other site 718219002175 ADP binding site [chemical binding]; other site 718219002176 catalytic site [active] 718219002177 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 718219002178 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 718219002179 minor groove reading motif; other site 718219002180 helix-hairpin-helix signature motif; other site 718219002181 substrate binding pocket [chemical binding]; other site 718219002182 active site 718219002183 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 718219002184 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 718219002185 trmE is a tRNA modification GTPase; Region: trmE; cd04164 718219002186 G1 box; other site 718219002187 GTP/Mg2+ binding site [chemical binding]; other site 718219002188 Switch I region; other site 718219002189 G2 box; other site 718219002190 Switch II region; other site 718219002191 G3 box; other site 718219002192 G4 box; other site 718219002193 G5 box; other site 718219002194 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 718219002195 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 718219002196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718219002197 binding surface 718219002198 TPR motif; other site 718219002199 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 718219002200 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 718219002201 ATP binding site [chemical binding]; other site 718219002202 putative Mg++ binding site [ion binding]; other site 718219002203 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 718219002204 Predicted GTPases [General function prediction only]; Region: COG1160 718219002205 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 718219002206 G1 box; other site 718219002207 GTP/Mg2+ binding site [chemical binding]; other site 718219002208 Switch I region; other site 718219002209 G2 box; other site 718219002210 Switch II region; other site 718219002211 G3 box; other site 718219002212 G4 box; other site 718219002213 G5 box; other site 718219002214 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 718219002215 G1 box; other site 718219002216 GTP/Mg2+ binding site [chemical binding]; other site 718219002217 Switch I region; other site 718219002218 G2 box; other site 718219002219 G3 box; other site 718219002220 Switch II region; other site 718219002221 G4 box; other site 718219002222 G5 box; other site 718219002223 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 718219002224 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 718219002225 active site 718219002226 NTP binding site [chemical binding]; other site 718219002227 metal binding triad [ion binding]; metal-binding site 718219002228 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 718219002229 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 718219002230 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 718219002231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718219002232 Walker A motif; other site 718219002233 ATP binding site [chemical binding]; other site 718219002234 Walker B motif; other site 718219002235 arginine finger; other site 718219002236 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 718219002237 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 718219002238 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 718219002239 oligomer interface [polypeptide binding]; other site 718219002240 active site residues [active] 718219002241 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 718219002242 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 718219002243 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 718219002244 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 718219002245 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718219002246 ATP binding site [chemical binding]; other site 718219002247 putative Mg++ binding site [ion binding]; other site 718219002248 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718219002249 nucleotide binding region [chemical binding]; other site 718219002250 ATP-binding site [chemical binding]; other site 718219002251 rod shape-determining protein MreB; Provisional; Region: PRK13927 718219002252 MreB and similar proteins; Region: MreB_like; cd10225 718219002253 nucleotide binding site [chemical binding]; other site 718219002254 Mg binding site [ion binding]; other site 718219002255 putative protofilament interaction site [polypeptide binding]; other site 718219002256 RodZ interaction site [polypeptide binding]; other site 718219002257 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 718219002258 active site 718219002259 substrate-binding site [chemical binding]; other site 718219002260 metal-binding site [ion binding] 718219002261 GTP binding site [chemical binding]; other site 718219002262 Effector from type III secretion system; Region: Effector_1; pfam04518 718219002263 Effector from type III secretion system; Region: Effector_1; pfam04518 718219002264 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 718219002265 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 718219002266 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 718219002267 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 718219002268 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 718219002269 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 718219002270 active site 718219002271 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 718219002272 type III secretion system ATPase; Validated; Region: PRK05922 718219002273 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 718219002274 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 718219002275 Walker A motif; other site 718219002276 ATP binding site [chemical binding]; other site 718219002277 Walker B motif; other site 718219002278 type III secretion system protein; Validated; Region: PRK05934 718219002279 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 718219002280 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 718219002281 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 718219002282 active site 718219002283 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 718219002284 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 718219002285 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718219002286 catalytic residue [active] 718219002287 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 718219002288 catalytic core [active] 718219002289 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 718219002290 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718219002291 RNA binding surface [nucleotide binding]; other site 718219002292 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 718219002293 active site 718219002294 biotin--protein ligase; Provisional; Region: PRK05935 718219002295 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 718219002296 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 718219002297 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 718219002298 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 718219002299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718219002300 motif II; other site 718219002301 CCC1-related protein family; Region: CCC1_like_1; cd02437 718219002302 seryl-tRNA synthetase; Provisional; Region: PRK05431 718219002303 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 718219002304 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 718219002305 dimer interface [polypeptide binding]; other site 718219002306 active site 718219002307 motif 1; other site 718219002308 motif 2; other site 718219002309 motif 3; other site 718219002310 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 718219002311 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 718219002312 catalytic motif [active] 718219002313 Zn binding site [ion binding]; other site 718219002314 RibD C-terminal domain; Region: RibD_C; pfam01872 718219002315 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 718219002316 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 718219002317 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 718219002318 dimerization interface [polypeptide binding]; other site 718219002319 active site 718219002320 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 718219002321 homopentamer interface [polypeptide binding]; other site 718219002322 active site 718219002323 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 718219002324 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 718219002325 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 718219002326 substrate binding site [chemical binding]; other site 718219002327 Proteins containing SET domain [General function prediction only]; Region: COG2940 718219002328 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 718219002329 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 718219002330 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 718219002331 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 718219002332 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 718219002333 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 718219002334 potential protein location (hypothetical protein CTG9301_03925 [Chlamydia trachomatis G/9301]) that overlaps RNA (tRNA-H) 718219002335 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 718219002336 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 718219002337 catalytic loop [active] 718219002338 iron binding site [ion binding]; other site 718219002339 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 718219002340 FAD binding pocket [chemical binding]; other site 718219002341 FAD binding motif [chemical binding]; other site 718219002342 phosphate binding motif [ion binding]; other site 718219002343 beta-alpha-beta structure motif; other site 718219002344 NAD binding pocket [chemical binding]; other site 718219002345 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 718219002346 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 718219002347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718219002348 S-adenosylmethionine binding site [chemical binding]; other site 718219002349 Histone H1-like protein Hc1; Region: Hc1; pfam07432 718219002350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718219002351 binding surface 718219002352 TPR motif; other site 718219002353 Tetratricopeptide repeat; Region: TPR_12; pfam13424 718219002354 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 718219002355 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 718219002356 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 718219002357 HemN C-terminal domain; Region: HemN_C; pfam06969 718219002358 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 718219002359 substrate binding site [chemical binding]; other site 718219002360 active site 718219002361 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 718219002362 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 718219002363 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718219002364 ATP binding site [chemical binding]; other site 718219002365 putative Mg++ binding site [ion binding]; other site 718219002366 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718219002367 nucleotide binding region [chemical binding]; other site 718219002368 ATP-binding site [chemical binding]; other site 718219002369 TRCF domain; Region: TRCF; pfam03461 718219002370 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 718219002371 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 718219002372 motif 1; other site 718219002373 active site 718219002374 motif 2; other site 718219002375 motif 3; other site 718219002376 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 718219002377 DHHA1 domain; Region: DHHA1; pfam02272 718219002378 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 718219002379 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 718219002380 TPP-binding site [chemical binding]; other site 718219002381 dimer interface [polypeptide binding]; other site 718219002382 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 718219002383 PYR/PP interface [polypeptide binding]; other site 718219002384 dimer interface [polypeptide binding]; other site 718219002385 TPP binding site [chemical binding]; other site 718219002386 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 718219002387 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 718219002388 elongation factor P; Validated; Region: PRK00529 718219002389 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 718219002390 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 718219002391 RNA binding site [nucleotide binding]; other site 718219002392 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 718219002393 RNA binding site [nucleotide binding]; other site 718219002394 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 718219002395 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 718219002396 putative active site [active] 718219002397 putative metal binding site [ion binding]; other site 718219002398 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 718219002399 active site 718219002400 metal binding site [ion binding]; metal-binding site 718219002401 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 718219002402 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 718219002403 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 718219002404 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718219002405 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 718219002406 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 718219002407 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 718219002408 Mg++ binding site [ion binding]; other site 718219002409 putative catalytic motif [active] 718219002410 putative substrate binding site [chemical binding]; other site 718219002411 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 718219002412 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 718219002413 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718219002414 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 718219002415 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 718219002416 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 718219002417 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 718219002418 cell division protein FtsW; Region: ftsW; TIGR02614 718219002419 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 718219002420 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 718219002421 active site 718219002422 homodimer interface [polypeptide binding]; other site 718219002423 bifunctional D-alanyl-alanine synthetase A/UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: PRK14573 718219002424 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 718219002425 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718219002426 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 718219002427 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 718219002428 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 718219002429 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 718219002430 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409 718219002431 G-X-X-G motif; other site 718219002432 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 718219002433 anti sigma factor interaction site; other site 718219002434 regulatory phosphorylation site [posttranslational modification]; other site 718219002435 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 718219002436 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 718219002437 hypothetical protein; Provisional; Region: PRK05927 718219002438 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 718219002439 FeS/SAM binding site; other site 718219002440 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 718219002441 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 718219002442 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 718219002443 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 718219002444 dimer interface [polypeptide binding]; other site 718219002445 active site 718219002446 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 718219002447 active site 718219002448 Ap4A binding cleft/pocket [chemical binding]; other site 718219002449 P4 phosphate binding site; other site 718219002450 nudix motif; other site 718219002451 putative P2/P3 phosphate binding site [ion binding]; other site 718219002452 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 718219002453 dimer interface [polypeptide binding]; other site 718219002454 substrate binding site [chemical binding]; other site 718219002455 metal binding sites [ion binding]; metal-binding site 718219002456 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 718219002457 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 718219002458 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 718219002459 NAD binding site [chemical binding]; other site 718219002460 Phe binding site; other site 718219002461 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 718219002462 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 718219002463 active site 718219002464 putative lithium-binding site [ion binding]; other site 718219002465 substrate binding site [chemical binding]; other site 718219002466 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 718219002467 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 718219002468 putative acyl-acceptor binding pocket; other site 718219002469 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 718219002470 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 718219002471 acyl-activating enzyme (AAE) consensus motif; other site 718219002472 AMP binding site [chemical binding]; other site 718219002473 active site 718219002474 CoA binding site [chemical binding]; other site 718219002475 8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937 718219002476 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 718219002477 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718219002478 catalytic residue [active] 718219002479 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 718219002480 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718219002481 ATP binding site [chemical binding]; other site 718219002482 putative Mg++ binding site [ion binding]; other site 718219002483 helicase superfamily c-terminal domain; Region: HELICc; smart00490 718219002484 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 718219002485 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 718219002486 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 718219002487 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 718219002488 dimer interface [polypeptide binding]; other site 718219002489 putative anticodon binding site; other site 718219002490 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 718219002491 motif 1; other site 718219002492 dimer interface [polypeptide binding]; other site 718219002493 active site 718219002494 motif 2; other site 718219002495 motif 3; other site 718219002496 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 718219002497 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 718219002498 active site 718219002499 HIGH motif; other site 718219002500 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 718219002501 KMSKS motif; other site 718219002502 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 718219002503 tRNA binding surface [nucleotide binding]; other site 718219002504 anticodon binding site; other site 718219002505 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 718219002506 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 718219002507 ribonuclease P; Reviewed; Region: rnpA; PRK00730 718219002508 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 718219002509 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 718219002510 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 718219002511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 718219002512 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 718219002513 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 718219002514 GIY-YIG motif/motif A; other site 718219002515 active site 718219002516 catalytic site [active] 718219002517 putative DNA binding site [nucleotide binding]; other site 718219002518 metal binding site [ion binding]; metal-binding site 718219002519 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 718219002520 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 718219002521 MutS domain I; Region: MutS_I; pfam01624 718219002522 MutS domain II; Region: MutS_II; pfam05188 718219002523 MutS domain III; Region: MutS_III; pfam05192 718219002524 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 718219002525 Walker A/P-loop; other site 718219002526 ATP binding site [chemical binding]; other site 718219002527 Q-loop/lid; other site 718219002528 ABC transporter signature motif; other site 718219002529 Walker B; other site 718219002530 D-loop; other site 718219002531 H-loop/switch region; other site 718219002532 DNA primase; Validated; Region: dnaG; PRK05667 718219002533 CHC2 zinc finger; Region: zf-CHC2; pfam01807 718219002534 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 718219002535 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 718219002536 active site 718219002537 metal binding site [ion binding]; metal-binding site 718219002538 interdomain interaction site; other site 718219002539 glycyl-tRNA synthetase; Provisional; Region: PRK14908 718219002540 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 718219002541 dimer interface [polypeptide binding]; other site 718219002542 motif 1; other site 718219002543 active site 718219002544 motif 2; other site 718219002545 motif 3; other site 718219002546 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 718219002547 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 718219002548 glycogen synthase; Provisional; Region: glgA; PRK00654 718219002549 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 718219002550 ADP-binding pocket [chemical binding]; other site 718219002551 homodimer interface [polypeptide binding]; other site 718219002552 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 718219002553 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 718219002554 5S rRNA interface [nucleotide binding]; other site 718219002555 CTC domain interface [polypeptide binding]; other site 718219002556 L16 interface [polypeptide binding]; other site 718219002557 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 718219002558 putative active site [active] 718219002559 catalytic residue [active] 718219002560 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 718219002561 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 718219002562 Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359 718219002563 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 718219002564 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 718219002565 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK00650 718219002566 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 718219002567 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 718219002568 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 718219002569 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 718219002570 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 718219002571 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 718219002572 putative acyl-acceptor binding pocket; other site 718219002573 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 718219002574 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 718219002575 homodimer interface [polypeptide binding]; other site 718219002576 oligonucleotide binding site [chemical binding]; other site 718219002577 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 718219002578 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 718219002579 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 718219002580 Autotransporter beta-domain; Region: Autotransporter; pfam03797 718219002581 YtxH-like protein; Region: YtxH; cl02079 718219002582 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 718219002583 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 718219002584 active site 718219002585 substrate binding site [chemical binding]; other site 718219002586 metal binding site [ion binding]; metal-binding site 718219002587 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 718219002588 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 718219002589 glutaminase active site [active] 718219002590 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 718219002591 dimer interface [polypeptide binding]; other site 718219002592 active site 718219002593 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 718219002594 dimer interface [polypeptide binding]; other site 718219002595 active site 718219002596 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 718219002597 aromatic amino acid transport protein; Region: araaP; TIGR00837 718219002598 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 718219002599 aromatic amino acid transport protein; Region: araaP; TIGR00837 718219002600 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 718219002601 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 718219002602 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 718219002603 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 718219002604 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718219002605 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 718219002606 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 718219002607 CoA-ligase; Region: Ligase_CoA; pfam00549 718219002608 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 718219002609 CoA binding domain; Region: CoA_binding; smart00881 718219002610 CoA-ligase; Region: Ligase_CoA; pfam00549 718219002611 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 718219002612 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 718219002613 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 718219002614 protein binding site [polypeptide binding]; other site 718219002615 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 718219002616 protein binding site [polypeptide binding]; other site 718219002617 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 718219002618 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 718219002619 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 718219002620 Peptidase M16C associated; Region: M16C_assoc; pfam08367 718219002621 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 718219002622 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 718219002623 RmuC family; Region: RmuC; pfam02646 718219002624 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 718219002625 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 718219002626 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 718219002627 ATP cone domain; Region: ATP-cone; pfam03477 718219002628 ATP cone domain; Region: ATP-cone; pfam03477 718219002629 Class I ribonucleotide reductase; Region: RNR_I; cd01679 718219002630 active site 718219002631 dimer interface [polypeptide binding]; other site 718219002632 catalytic residues [active] 718219002633 effector binding site; other site 718219002634 R2 peptide binding site; other site 718219002635 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 718219002636 dimer interface [polypeptide binding]; other site 718219002637 putative radical transfer pathway; other site 718219002638 diiron center [ion binding]; other site 718219002639 tyrosyl radical; other site 718219002640 Putative methyltransferase; Region: Methyltransf_4; pfam02390 718219002641 Methyltransferase domain; Region: Methyltransf_18; pfam12847 718219002642 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 718219002643 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 718219002644 FAD binding domain; Region: FAD_binding_4; pfam01565 718219002645 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 718219002646 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 718219002647 putative RNA binding site [nucleotide binding]; other site 718219002648 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 718219002649 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 718219002650 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 718219002651 Ribosomal protein L35 [Translation, ribosomal structure and biogenesis]; Region: RpmI; COG0291 718219002652 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 718219002653 23S rRNA binding site [nucleotide binding]; other site 718219002654 L21 binding site [polypeptide binding]; other site 718219002655 L13 binding site [polypeptide binding]; other site 718219002656 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 718219002657 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 718219002658 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 718219002659 motif 1; other site 718219002660 dimer interface [polypeptide binding]; other site 718219002661 active site 718219002662 motif 2; other site 718219002663 motif 3; other site 718219002664 potential protein location (hypothetical protein CTG9301_04460 [Chlamydia trachomatis G/9301]) that overlaps RNA (tRNA-S) 718219002665 Predicted permeases [General function prediction only]; Region: COG0795 718219002666 Predicted permeases [General function prediction only]; Region: COG0795 718219002667 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 718219002668 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 718219002669 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 718219002670 Ligand Binding Site [chemical binding]; other site 718219002671 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 718219002672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718219002673 Walker A motif; other site 718219002674 ATP binding site [chemical binding]; other site 718219002675 Walker B motif; other site 718219002676 arginine finger; other site 718219002677 Peptidase family M41; Region: Peptidase_M41; pfam01434 718219002678 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 718219002679 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 718219002680 RNase E interface [polypeptide binding]; other site 718219002681 trimer interface [polypeptide binding]; other site 718219002682 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 718219002683 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 718219002684 RNase E interface [polypeptide binding]; other site 718219002685 trimer interface [polypeptide binding]; other site 718219002686 active site 718219002687 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 718219002688 putative nucleic acid binding region [nucleotide binding]; other site 718219002689 G-X-X-G motif; other site 718219002690 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 718219002691 RNA binding site [nucleotide binding]; other site 718219002692 domain interface; other site 718219002693 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 718219002694 16S/18S rRNA binding site [nucleotide binding]; other site 718219002695 S13e-L30e interaction site [polypeptide binding]; other site 718219002696 25S rRNA binding site [nucleotide binding]; other site 718219002697 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 718219002698 nucleoside/Zn binding site; other site 718219002699 dimer interface [polypeptide binding]; other site 718219002700 catalytic motif [active] 718219002701 Protein of unknown function (DUF720); Region: DUF720; pfam05302 718219002702 Protein of unknown function (DUF720); Region: DUF720; pfam05302 718219002703 Protein of unknown function (DUF720); Region: DUF720; pfam05302 718219002704 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 718219002705 methionine aminopeptidase; Provisional; Region: PRK12318 718219002706 SEC-C motif; Region: SEC-C; pfam02810 718219002707 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 718219002708 active site 718219002709 MarC family integral membrane protein; Region: MarC; pfam01914 718219002710 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 718219002711 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 718219002712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718219002713 dimer interface [polypeptide binding]; other site 718219002714 conserved gate region; other site 718219002715 putative PBP binding loops; other site 718219002716 ABC-ATPase subunit interface; other site 718219002717 NMT1/THI5 like; Region: NMT1; pfam09084 718219002718 fumarate hydratase, class II; Region: fumC_II; TIGR00979 718219002719 Class II fumarases; Region: Fumarase_classII; cd01362 718219002720 active site 718219002721 tetramer interface [polypeptide binding]; other site 718219002722 high affinity sulphate transporter 1; Region: sulP; TIGR00815 718219002723 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 718219002724 Sulfate transporter family; Region: Sulfate_transp; pfam00916 718219002725 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 718219002726 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 718219002727 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 718219002728 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 718219002729 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 718219002730 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 718219002731 active site triad [active] 718219002732 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 718219002733 LytB protein; Region: LYTB; pfam02401 718219002734 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 718219002735 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 718219002736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718219002737 binding surface 718219002738 TPR motif; other site 718219002739 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 718219002740 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 718219002741 active site 718219002742 DNA binding site [nucleotide binding] 718219002743 Int/Topo IB signature motif; other site 718219002744 glycogen branching enzyme; Provisional; Region: PRK05402 718219002745 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 718219002746 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 718219002747 active site 718219002748 catalytic site [active] 718219002749 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 718219002750 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 718219002751 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 718219002752 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 718219002753 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 718219002754 Autotransporter beta-domain; Region: Autotransporter; pfam03797 718219002755 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 718219002756 Autotransporter beta-domain; Region: Autotransporter; pfam03797 718219002757 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 718219002758 Autotransporter beta-domain; Region: Autotransporter; pfam03797 718219002759 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 718219002760 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 718219002761 Autotransporter beta-domain; Region: Autotransporter; pfam03797 718219002762 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 718219002763 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 718219002764 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 718219002765 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 718219002766 Autotransporter beta-domain; Region: Autotransporter; pfam03797