-- dump date 20140619_032222 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272561000001 Uncharacterized conserved protein [Function unknown]; Region: COG2155 272561000002 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 272561000003 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 272561000004 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 272561000005 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272561000006 GatB domain; Region: GatB_Yqey; pfam02637 272561000007 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 272561000008 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 272561000009 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 272561000010 ribonuclease HIII; Region: rnhC; TIGR00716 272561000011 Bacterial type 2 ribonuclease, HII and HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 272561000012 RNA/DNA hybrid binding site [nucleotide binding]; other site 272561000013 active site 272561000014 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 272561000015 Helix-turn-helix domain; Region: HTH_25; pfam13413 272561000016 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 272561000017 putative acyl-acceptor binding pocket; other site 272561000018 Uncharacterized conserved protein [Function unknown]; Region: COG1624 272561000019 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 272561000020 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 272561000021 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 272561000022 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 272561000023 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 272561000024 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 272561000025 putative active site [active] 272561000026 PhoH-like protein; Region: PhoH; cl17668 272561000027 Bacterial SH3 domain homologues; Region: SH3b; smart00287 272561000028 Bacterial SH3 domain homologues; Region: SH3b; smart00287 272561000029 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 272561000030 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272561000031 active site 272561000032 HIGH motif; other site 272561000033 KMSKS motif; other site 272561000034 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 272561000035 tRNA binding surface [nucleotide binding]; other site 272561000036 anticodon binding site; other site 272561000037 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272561000038 Catalytic site [active] 272561000039 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 272561000040 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272561000041 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 272561000042 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272561000043 PCRF domain; Region: PCRF; pfam03462 272561000044 RF-1 domain; Region: RF-1; pfam00472 272561000045 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 272561000046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272561000047 S-adenosylmethionine binding site [chemical binding]; other site 272561000048 signal recognition particle protein; Region: ffh; TIGR00959 272561000049 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272561000050 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272561000051 P loop; other site 272561000052 GTP binding site [chemical binding]; other site 272561000053 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272561000054 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 272561000055 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 272561000056 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 272561000057 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272561000058 active site 272561000059 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 272561000060 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272561000061 RNA/DNA hybrid binding site [nucleotide binding]; other site 272561000062 active site 272561000063 Guanylate kinase; Region: Guanylate_kin; pfam00625 272561000064 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272561000065 catalytic site [active] 272561000066 G-X2-G-X-G-K; other site 272561000067 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 272561000068 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272561000069 active site 272561000070 HIGH motif; other site 272561000071 KMSKS motif; other site 272561000072 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272561000073 tRNA binding surface [nucleotide binding]; other site 272561000074 anticodon binding site; other site 272561000075 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 272561000076 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272561000077 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 272561000078 AAA domain; Region: AAA_30; pfam13604 272561000079 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272561000080 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272561000081 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 272561000082 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 272561000083 conserved cys residue [active] 272561000084 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272561000085 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272561000086 trimer interface [polypeptide binding]; other site 272561000087 active site 272561000088 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 272561000089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272561000090 Walker A motif; other site 272561000091 ATP binding site [chemical binding]; other site 272561000092 Walker B motif; other site 272561000093 arginine finger; other site 272561000094 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272561000095 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 272561000096 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 272561000097 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 272561000098 active site 272561000099 catalytic site [active] 272561000100 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 272561000101 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272561000102 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272561000103 dimer interface [polypeptide binding]; other site 272561000104 ssDNA binding site [nucleotide binding]; other site 272561000105 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272561000106 multifunctional aminopeptidase A; Provisional; Region: PRK00913 272561000107 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272561000108 interface (dimer of trimers) [polypeptide binding]; other site 272561000109 Substrate-binding/catalytic site; other site 272561000110 Zn-binding sites [ion binding]; other site 272561000111 Histone H1-like nucleoprotein HC2; Region: HC2; pfam07382 272561000112 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 272561000113 hypothetical protein; Provisional; Region: PRK05907 272561000114 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 272561000115 putative SAM binding site [chemical binding]; other site 272561000116 homodimer interface [polypeptide binding]; other site 272561000117 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cl00322 272561000118 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 272561000119 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272561000120 FeS/SAM binding site; other site 272561000121 HemN C-terminal domain; Region: HemN_C; pfam06969 272561000122 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 272561000123 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 272561000124 TPP-binding site [chemical binding]; other site 272561000125 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 272561000126 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 272561000127 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272561000128 E3 interaction surface; other site 272561000129 lipoyl attachment site [posttranslational modification]; other site 272561000130 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272561000131 uncharacterized protein, YfiH family; Region: TIGR00726 272561000132 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 272561000133 GcpE protein; Region: GcpE; pfam04551 272561000134 IncA protein; Region: IncA; pfam04156 272561000135 Appr-1"-p processing enzyme; Region: A1pp; smart00506 272561000136 ADP-ribose binding site [chemical binding]; other site 272561000137 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272561000138 catalytic loop [active] 272561000139 iron binding site [ion binding]; other site 272561000140 type III secretion system protein; Validated; Region: PRK05910 272561000141 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 272561000142 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272561000143 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272561000144 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272561000145 DNA binding residues [nucleotide binding] 272561000146 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 272561000147 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272561000148 active site 272561000149 HIGH motif; other site 272561000150 dimer interface [polypeptide binding]; other site 272561000151 KMSKS motif; other site 272561000152 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272561000153 RNA binding surface [nucleotide binding]; other site 272561000154 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 272561000155 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 272561000156 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 272561000157 GTP-binding protein LepA; Provisional; Region: PRK05433 272561000158 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272561000159 G1 box; other site 272561000160 putative GEF interaction site [polypeptide binding]; other site 272561000161 GTP/Mg2+ binding site [chemical binding]; other site 272561000162 Switch I region; other site 272561000163 G2 box; other site 272561000164 G3 box; other site 272561000165 Switch II region; other site 272561000166 G4 box; other site 272561000167 G5 box; other site 272561000168 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272561000169 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272561000170 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272561000171 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272561000172 ADP/ATP carrier protein family; Region: AAA; TIGR00769 272561000173 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272561000174 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272561000175 intersubunit interface [polypeptide binding]; other site 272561000176 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272561000177 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 272561000178 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272561000179 ABC-ATPase subunit interface; other site 272561000180 dimer interface [polypeptide binding]; other site 272561000181 putative PBP binding regions; other site 272561000182 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 272561000183 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 272561000184 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 272561000185 ABC-ATPase subunit interface; other site 272561000186 dimer interface [polypeptide binding]; other site 272561000187 putative PBP binding regions; other site 272561000188 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 272561000189 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 272561000190 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 272561000191 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 272561000192 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 272561000193 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272561000194 active site 272561000195 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 272561000196 putative substrate binding region [chemical binding]; other site 272561000197 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272561000198 Putative serine esterase (DUF676); Region: DUF676; pfam05057 272561000199 recF protein; Region: recf; TIGR00611 272561000200 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272561000201 Walker A/P-loop; other site 272561000202 ATP binding site [chemical binding]; other site 272561000203 Q-loop/lid; other site 272561000204 ABC transporter signature motif; other site 272561000205 Walker B; other site 272561000206 D-loop; other site 272561000207 H-loop/switch region; other site 272561000208 DNA polymerase III subunit beta; Validated; Region: PRK05643 272561000209 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272561000210 putative DNA binding surface [nucleotide binding]; other site 272561000211 dimer interface [polypeptide binding]; other site 272561000212 beta-clamp/clamp loader binding surface; other site 272561000213 beta-clamp/translesion DNA polymerase binding surface; other site 272561000214 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272561000215 SmpB-tmRNA interface; other site 272561000216 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 272561000217 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 272561000218 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272561000219 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 272561000220 homodimer interface [polypeptide binding]; other site 272561000221 NADP binding site [chemical binding]; other site 272561000222 substrate binding site [chemical binding]; other site 272561000223 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272561000224 PLD-like domain; Region: PLDc_2; pfam13091 272561000225 putative active site [active] 272561000226 catalytic site [active] 272561000227 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 272561000228 PLD-like domain; Region: PLDc_2; pfam13091 272561000229 putative active site [active] 272561000230 catalytic site [active] 272561000231 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 272561000232 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 272561000233 4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446 272561000234 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 272561000235 HrpJ-like domain; Region: HrpJ; cl15454 272561000236 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 272561000237 type III secretion system protein; Validated; Region: PRK06298 272561000238 GTP-binding protein YchF; Reviewed; Region: PRK09601 272561000239 YchF GTPase; Region: YchF; cd01900 272561000240 G1 box; other site 272561000241 GTP/Mg2+ binding site [chemical binding]; other site 272561000242 Switch I region; other site 272561000243 G2 box; other site 272561000244 Switch II region; other site 272561000245 G3 box; other site 272561000246 G4 box; other site 272561000247 G5 box; other site 272561000248 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 272561000249 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 272561000250 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 272561000251 active site 272561000252 Riboflavin kinase; Region: Flavokinase; smart00904 272561000253 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 272561000254 RNA binding site [nucleotide binding]; other site 272561000255 active site 272561000256 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 272561000257 translation initiation factor IF-2; Validated; Region: infB; PRK05306 272561000258 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272561000259 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272561000260 G1 box; other site 272561000261 putative GEF interaction site [polypeptide binding]; other site 272561000262 GTP/Mg2+ binding site [chemical binding]; other site 272561000263 Switch I region; other site 272561000264 G2 box; other site 272561000265 G3 box; other site 272561000266 Switch II region; other site 272561000267 G4 box; other site 272561000268 G5 box; other site 272561000269 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272561000270 Translation-initiation factor 2; Region: IF-2; pfam11987 272561000271 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272561000272 transcription termination factor NusA; Region: NusA; TIGR01953 272561000273 NusA N-terminal domain; Region: NusA_N; pfam08529 272561000274 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 272561000275 RNA binding site [nucleotide binding]; other site 272561000276 homodimer interface [polypeptide binding]; other site 272561000277 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272561000278 G-X-X-G motif; other site 272561000279 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272561000280 G-X-X-G motif; other site 272561000281 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272561000282 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 272561000283 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 272561000284 RNA binding site [nucleotide binding]; other site 272561000285 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 272561000286 RNA binding site [nucleotide binding]; other site 272561000287 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 272561000288 RNA binding site [nucleotide binding]; other site 272561000289 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272561000290 RNA binding site [nucleotide binding]; other site 272561000291 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272561000292 RNA binding site [nucleotide binding]; other site 272561000293 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 272561000294 RNA binding site [nucleotide binding]; other site 272561000295 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272561000296 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272561000297 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272561000298 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 272561000299 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 272561000300 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272561000301 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272561000302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272561000303 active site 272561000304 motif I; other site 272561000305 motif II; other site 272561000306 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 272561000307 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 272561000308 NAD binding site [chemical binding]; other site 272561000309 homotetramer interface [polypeptide binding]; other site 272561000310 homodimer interface [polypeptide binding]; other site 272561000311 substrate binding site [chemical binding]; other site 272561000312 active site 272561000313 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272561000314 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272561000315 RNA binding surface [nucleotide binding]; other site 272561000316 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272561000317 active site 272561000318 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 272561000319 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272561000320 minor groove reading motif; other site 272561000321 helix-hairpin-helix signature motif; other site 272561000322 substrate binding pocket [chemical binding]; other site 272561000323 active site 272561000324 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 272561000325 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 272561000326 DNA binding and oxoG recognition site [nucleotide binding] 272561000327 Uncharacterized conserved protein [Function unknown]; Region: COG0327 272561000328 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 272561000329 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272561000330 ring oligomerisation interface [polypeptide binding]; other site 272561000331 ATP/Mg binding site [chemical binding]; other site 272561000332 stacking interactions; other site 272561000333 hinge regions; other site 272561000334 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272561000335 oligomerisation interface [polypeptide binding]; other site 272561000336 mobile loop; other site 272561000337 roof hairpin; other site 272561000338 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 272561000339 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 272561000340 active site 272561000341 Zn binding site [ion binding]; other site 272561000342 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 272561000343 Clp amino terminal domain; Region: Clp_N; pfam02861 272561000344 Clp amino terminal domain; Region: Clp_N; pfam02861 272561000345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272561000346 Walker A motif; other site 272561000347 ATP binding site [chemical binding]; other site 272561000348 Walker B motif; other site 272561000349 arginine finger; other site 272561000350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272561000351 Walker A motif; other site 272561000352 ATP binding site [chemical binding]; other site 272561000353 Walker B motif; other site 272561000354 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272561000355 Uncharacterized conserved protein [Function unknown]; Region: COG2912 272561000356 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 272561000357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272561000358 TPR motif; other site 272561000359 binding surface 272561000360 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 272561000361 IncA protein; Region: IncA; pfam04156 272561000362 IncA protein; Region: IncA; pfam04156 272561000363 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272561000364 substrate binding site [chemical binding]; other site 272561000365 hexamer interface [polypeptide binding]; other site 272561000366 metal binding site [ion binding]; metal-binding site 272561000367 elongation factor P; Provisional; Region: PRK12426 272561000368 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272561000369 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272561000370 RNA binding site [nucleotide binding]; other site 272561000371 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272561000372 RNA binding site [nucleotide binding]; other site 272561000373 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 272561000374 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272561000375 carboxyltransferase (CT) interaction site; other site 272561000376 biotinylation site [posttranslational modification]; other site 272561000377 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 272561000378 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272561000379 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272561000380 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272561000381 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272561000382 23S rRNA interface [nucleotide binding]; other site 272561000383 L3 interface [polypeptide binding]; other site 272561000384 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 272561000385 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272561000386 NlpC/P60 family; Region: NLPC_P60; cl17555 272561000387 adenylate kinase; Reviewed; Region: adk; PRK00279 272561000388 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272561000389 AMP-binding site [chemical binding]; other site 272561000390 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272561000391 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272561000392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272561000393 dimer interface [polypeptide binding]; other site 272561000394 conserved gate region; other site 272561000395 putative PBP binding loops; other site 272561000396 ABC-ATPase subunit interface; other site 272561000397 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272561000398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272561000399 Walker A/P-loop; other site 272561000400 ATP binding site [chemical binding]; other site 272561000401 Q-loop/lid; other site 272561000402 ABC transporter signature motif; other site 272561000403 Walker B; other site 272561000404 D-loop; other site 272561000405 H-loop/switch region; other site 272561000406 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 272561000407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272561000408 S-adenosylmethionine binding site [chemical binding]; other site 272561000409 Predicted esterase [General function prediction only]; Region: COG0400 272561000410 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 272561000411 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 272561000412 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 272561000413 active site 272561000414 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272561000415 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 272561000416 conserved hypothetical integral membrane protein; Region: TIGR00697 272561000417 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 272561000418 SEC-C motif; Region: SEC-C; cl19389 272561000419 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272561000420 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272561000421 active site 272561000422 ATP binding site [chemical binding]; other site 272561000423 substrate binding site [chemical binding]; other site 272561000424 activation loop (A-loop); other site 272561000425 Uncharacterized conserved protein [Function unknown]; Region: COG1262 272561000426 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; pfam03781 272561000427 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272561000428 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 272561000429 nucleotide binding pocket [chemical binding]; other site 272561000430 K-X-D-G motif; other site 272561000431 catalytic site [active] 272561000432 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272561000433 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 272561000434 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272561000435 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 272561000436 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272561000437 Dimer interface [polypeptide binding]; other site 272561000438 BRCT sequence motif; other site 272561000439 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 272561000440 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272561000441 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 272561000442 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272561000443 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 272561000444 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272561000445 FtsX-like permease family; Region: FtsX; pfam02687 272561000446 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272561000447 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272561000448 Walker A/P-loop; other site 272561000449 ATP binding site [chemical binding]; other site 272561000450 Q-loop/lid; other site 272561000451 ABC transporter signature motif; other site 272561000452 Walker B; other site 272561000453 D-loop; other site 272561000454 H-loop/switch region; other site 272561000455 membrane-attack complex / perforin; Region: MACPF; smart00457 272561000456 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 272561000457 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272561000458 PLD-like domain; Region: PLDc_2; pfam13091 272561000459 putative active site [active] 272561000460 catalytic site [active] 272561000461 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 272561000462 PLD-like domain; Region: PLDc_2; pfam13091 272561000463 putative active site [active] 272561000464 catalytic site [active] 272561000465 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272561000466 PLD-like domain; Region: PLDc_2; pfam13091 272561000467 putative active site [active] 272561000468 catalytic site [active] 272561000469 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272561000470 PLD-like domain; Region: PLDc_2; pfam13091 272561000471 putative active site [active] 272561000472 catalytic site [active] 272561000473 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272561000474 PLD-like domain; Region: PLDc_2; pfam13091 272561000475 putative active site [active] 272561000476 catalytic site [active] 272561000477 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 272561000478 PLD-like domain; Region: PLDc_2; pfam13091 272561000479 putative active site [active] 272561000480 catalytic site [active] 272561000481 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272561000482 PLD-like domain; Region: PLDc_2; pfam13091 272561000483 putative active site [active] 272561000484 catalytic site [active] 272561000485 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 272561000486 PLD-like domain; Region: PLDc_2; pfam13091 272561000487 putative active site [active] 272561000488 catalytic site [active] 272561000489 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272561000490 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 272561000491 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 272561000492 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 272561000493 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272561000494 trp operon repressor, proteobacterial; Region: TrpR; TIGR01321 272561000495 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 272561000496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272561000497 catalytic residue [active] 272561000498 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 272561000499 substrate binding site [chemical binding]; other site 272561000500 active site 272561000501 catalytic residues [active] 272561000502 heterodimer interface [polypeptide binding]; other site 272561000503 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272561000504 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272561000505 peptide binding site [polypeptide binding]; other site 272561000506 putative disulfide oxidoreductase; Provisional; Region: PRK00611 272561000507 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 272561000508 Thioredoxin; Region: Thioredoxin_4; cl17273 272561000509 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 272561000510 putative active site [active] 272561000511 redox center [active] 272561000512 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272561000513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272561000514 Walker A/P-loop; other site 272561000515 ATP binding site [chemical binding]; other site 272561000516 Q-loop/lid; other site 272561000517 ABC transporter signature motif; other site 272561000518 Walker B; other site 272561000519 D-loop; other site 272561000520 H-loop/switch region; other site 272561000521 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 272561000522 Ligand binding site; other site 272561000523 oligomer interface; other site 272561000524 CTP synthetase; Validated; Region: pyrG; PRK05380 272561000525 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272561000526 Catalytic site [active] 272561000527 active site 272561000528 UTP binding site [chemical binding]; other site 272561000529 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272561000530 active site 272561000531 putative oxyanion hole; other site 272561000532 catalytic triad [active] 272561000533 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 272561000534 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 272561000535 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 272561000536 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 272561000537 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 272561000538 putative active site [active] 272561000539 DNA polymerase III subunit delta'; Validated; Region: PRK05917 272561000540 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272561000541 thymidylate kinase; Validated; Region: tmk; PRK00698 272561000542 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272561000543 TMP-binding site; other site 272561000544 ATP-binding site [chemical binding]; other site 272561000545 DNA gyrase, A subunit; Region: gyrA; TIGR01063 272561000546 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272561000547 CAP-like domain; other site 272561000548 active site 272561000549 primary dimer interface [polypeptide binding]; other site 272561000550 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272561000551 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272561000552 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272561000553 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272561000554 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272561000555 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272561000556 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 272561000557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272561000558 ATP binding site [chemical binding]; other site 272561000559 Mg2+ binding site [ion binding]; other site 272561000560 G-X-G motif; other site 272561000561 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272561000562 anchoring element; other site 272561000563 dimer interface [polypeptide binding]; other site 272561000564 ATP binding site [chemical binding]; other site 272561000565 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272561000566 active site 272561000567 putative metal-binding site [ion binding]; other site 272561000568 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272561000569 Protein of unknown function (DUF721); Region: DUF721; pfam05258 272561000570 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 272561000571 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 272561000572 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 272561000573 MgtE intracellular N domain; Region: MgtE_N; pfam03448 272561000574 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 272561000575 Divalent cation transporter; Region: MgtE; pfam01769 272561000576 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 272561000577 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 272561000578 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272561000579 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272561000580 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272561000581 peptide binding site [polypeptide binding]; other site 272561000582 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272561000583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272561000584 dimer interface [polypeptide binding]; other site 272561000585 conserved gate region; other site 272561000586 putative PBP binding loops; other site 272561000587 ABC-ATPase subunit interface; other site 272561000588 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272561000589 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272561000590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272561000591 dimer interface [polypeptide binding]; other site 272561000592 conserved gate region; other site 272561000593 putative PBP binding loops; other site 272561000594 ABC-ATPase subunit interface; other site 272561000595 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272561000596 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 272561000597 Walker A/P-loop; other site 272561000598 ATP binding site [chemical binding]; other site 272561000599 Q-loop/lid; other site 272561000600 ABC transporter signature motif; other site 272561000601 Walker B; other site 272561000602 D-loop; other site 272561000603 H-loop/switch region; other site 272561000604 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272561000605 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272561000606 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272561000607 Walker A/P-loop; other site 272561000608 ATP binding site [chemical binding]; other site 272561000609 Q-loop/lid; other site 272561000610 ABC transporter signature motif; other site 272561000611 Walker B; other site 272561000612 D-loop; other site 272561000613 H-loop/switch region; other site 272561000614 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272561000615 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 272561000616 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 272561000617 anion transporter; Region: dass; TIGR00785 272561000618 transmembrane helices; other site 272561000619 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 272561000620 active site 272561000621 ADP/pyrophosphate binding site [chemical binding]; other site 272561000622 dimerization interface [polypeptide binding]; other site 272561000623 allosteric effector site; other site 272561000624 fructose-1,6-bisphosphate binding site; other site 272561000625 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272561000626 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272561000627 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272561000628 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 272561000629 active site 272561000630 ADP/pyrophosphate binding site [chemical binding]; other site 272561000631 dimerization interface [polypeptide binding]; other site 272561000632 allosteric effector site; other site 272561000633 fructose-1,6-bisphosphate binding site; other site 272561000634 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 272561000635 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 272561000636 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272561000637 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272561000638 active site 272561000639 HIGH motif; other site 272561000640 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272561000641 KMSKS motif; other site 272561000642 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272561000643 tRNA binding surface [nucleotide binding]; other site 272561000644 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 272561000645 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272561000646 inhibitor-cofactor binding pocket; inhibition site 272561000647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272561000648 catalytic residue [active] 272561000649 Putative transcriptional regulator [Transcription]; Region: COG1678 272561000650 Uncharacterized conserved protein [Function unknown]; Region: COG1259 272561000651 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 272561000652 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272561000653 active site 272561000654 dimer interface [polypeptide binding]; other site 272561000655 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 272561000656 putative active site; other site 272561000657 catalytic residue [active] 272561000658 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 272561000659 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272561000660 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 272561000661 Ligand Binding Site [chemical binding]; other site 272561000662 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 272561000663 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 272561000664 putative active site [active] 272561000665 aromatic acid decarboxylase; Validated; Region: PRK05920 272561000666 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272561000667 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272561000668 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272561000669 IncA protein; Region: IncA; pfam04156 272561000670 IncA protein; Region: IncA; pfam04156 272561000671 Orbivirus outer capsid protein VP5; Region: Orbi_VP5; pfam00901 272561000672 IncA protein; Region: IncA; pfam04156 272561000673 IncA protein; Region: IncA; pfam04156 272561000674 IncA protein; Region: IncA; pfam04156 272561000675 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 272561000676 Na+-dependent transporters of the SNF family [General function prediction only]; Region: COG0733 272561000677 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 272561000678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272561000679 putative substrate translocation pore; other site 272561000680 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272561000681 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272561000682 ligand binding site [chemical binding]; other site 272561000683 flexible hinge region; other site 272561000684 acyl carrier protein; Provisional; Region: acpP; PRK00982 272561000685 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 272561000686 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 272561000687 NAD(P) binding site [chemical binding]; other site 272561000688 homotetramer interface [polypeptide binding]; other site 272561000689 homodimer interface [polypeptide binding]; other site 272561000690 active site 272561000691 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272561000692 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 272561000693 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272561000694 dimer interface [polypeptide binding]; other site 272561000695 active site 272561000696 CoA binding pocket [chemical binding]; other site 272561000697 recombination protein RecR; Region: recR; TIGR00615 272561000698 RecR protein; Region: RecR; pfam02132 272561000699 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 272561000700 putative active site [active] 272561000701 putative metal-binding site [ion binding]; other site 272561000702 tetramer interface [polypeptide binding]; other site 272561000703 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 272561000704 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272561000705 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272561000706 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272561000707 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272561000708 Surface antigen; Region: Bac_surface_Ag; pfam01103 272561000709 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 272561000710 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 272561000711 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 272561000712 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 272561000713 trimer interface [polypeptide binding]; other site 272561000714 active site 272561000715 UDP-GlcNAc binding site [chemical binding]; other site 272561000716 lipid binding site [chemical binding]; lipid-binding site 272561000717 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272561000718 tetramer interface [polypeptide binding]; other site 272561000719 TPP-binding site [chemical binding]; other site 272561000720 heterodimer interface [polypeptide binding]; other site 272561000721 phosphorylation loop region [posttranslational modification] 272561000722 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272561000723 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272561000724 alpha subunit interface [polypeptide binding]; other site 272561000725 TPP binding site [chemical binding]; other site 272561000726 heterodimer interface [polypeptide binding]; other site 272561000727 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272561000728 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 272561000729 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272561000730 E3 interaction surface; other site 272561000731 lipoyl attachment site [posttranslational modification]; other site 272561000732 e3 binding domain; Region: E3_binding; pfam02817 272561000733 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272561000734 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 272561000735 homodimer interface [polypeptide binding]; other site 272561000736 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 272561000737 active site pocket [active] 272561000738 chromosomal replication initiation protein; Provisional; Region: PRK12422 272561000739 DnaA N-terminal domain; Region: DnaA_N; pfam11638 272561000740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272561000741 Walker A motif; other site 272561000742 ATP binding site [chemical binding]; other site 272561000743 Walker B motif; other site 272561000744 arginine finger; other site 272561000745 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272561000746 DnaA box-binding interface [nucleotide binding]; other site 272561000747 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 272561000748 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 272561000749 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 272561000750 CAAX protease self-immunity; Region: Abi; pfam02517 272561000751 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 272561000752 homodimer interface [polypeptide binding]; other site 272561000753 metal binding site [ion binding]; metal-binding site 272561000754 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272561000755 Domain of unknown function DUF21; Region: DUF21; pfam01595 272561000756 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272561000757 Transporter associated domain; Region: CorC_HlyC; smart01091 272561000758 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272561000759 Domain of unknown function DUF21; Region: DUF21; pfam01595 272561000760 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272561000761 Transporter associated domain; Region: CorC_HlyC; smart01091 272561000762 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272561000763 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272561000764 catalytic residue [active] 272561000765 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272561000766 active site 272561000767 Uncharacterized conserved protein [Function unknown]; Region: COG5465 272561000768 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 272561000769 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272561000770 active site 272561000771 catalytic site [active] 272561000772 substrate binding site [chemical binding]; other site 272561000773 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 272561000774 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 272561000775 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 272561000776 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272561000777 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272561000778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272561000779 Walker A/P-loop; other site 272561000780 ATP binding site [chemical binding]; other site 272561000781 Q-loop/lid; other site 272561000782 ABC transporter signature motif; other site 272561000783 Walker B; other site 272561000784 D-loop; other site 272561000785 H-loop/switch region; other site 272561000786 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 272561000787 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 272561000788 dimer interface [polypeptide binding]; other site 272561000789 DNA binding site [nucleotide binding] 272561000790 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 272561000791 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272561000792 active site 272561000793 metal binding site [ion binding]; metal-binding site 272561000794 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 272561000795 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272561000796 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272561000797 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272561000798 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272561000799 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272561000800 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272561000801 MraW methylase family; Region: Methyltransf_5; pfam01795 272561000802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272561000803 TPR motif; other site 272561000804 binding surface 272561000805 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 272561000806 DnaA N-terminal domain; Region: DnaA_N; pfam11638 272561000807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272561000808 Walker A motif; other site 272561000809 ATP binding site [chemical binding]; other site 272561000810 Walker B motif; other site 272561000811 arginine finger; other site 272561000812 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272561000813 DnaA box-binding interface [nucleotide binding]; other site 272561000814 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 272561000815 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 272561000816 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 272561000817 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 272561000818 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 272561000819 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 272561000820 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 272561000821 lipoyl attachment site [posttranslational modification]; other site 272561000822 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 272561000823 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 272561000824 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272561000825 putative active site [active] 272561000826 catalytic site [active] 272561000827 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272561000828 putative active site [active] 272561000829 catalytic site [active] 272561000830 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 272561000831 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 272561000832 Clp amino terminal domain; Region: Clp_N; pfam02861 272561000833 Clp amino terminal domain; Region: Clp_N; pfam02861 272561000834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272561000835 Walker A motif; other site 272561000836 ATP binding site [chemical binding]; other site 272561000837 Walker B motif; other site 272561000838 arginine finger; other site 272561000839 UvrB/uvrC motif; Region: UVR; pfam02151 272561000840 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272561000841 Walker A motif; other site 272561000842 ATP binding site [chemical binding]; other site 272561000843 Walker B motif; other site 272561000844 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272561000845 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 272561000846 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272561000847 Ligand Binding Site [chemical binding]; other site 272561000848 IncA protein; Region: IncA; pfam04156 272561000849 IncA protein; Region: IncA; pfam04156 272561000850 Helix-turn-helix domain; Region: HTH_17; pfam12728 272561000851 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272561000852 active site 272561000853 phosphorylation site [posttranslational modification] 272561000854 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272561000855 active site 272561000856 phosphorylation site [posttranslational modification] 272561000857 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272561000858 trimer interface [polypeptide binding]; other site 272561000859 active site 272561000860 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 272561000861 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 272561000862 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 272561000863 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 272561000864 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272561000865 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 272561000866 active site 272561000867 substrate binding site [chemical binding]; other site 272561000868 metal binding site [ion binding]; metal-binding site 272561000869 ribonuclease III; Reviewed; Region: rnc; PRK00102 272561000870 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272561000871 dimerization interface [polypeptide binding]; other site 272561000872 active site 272561000873 metal binding site [ion binding]; metal-binding site 272561000874 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272561000875 dsRNA binding site [nucleotide binding]; other site 272561000876 DNA repair protein RadA; Provisional; Region: PRK11823 272561000877 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 272561000878 Walker A motif/ATP binding site; other site 272561000879 ATP binding site [chemical binding]; other site 272561000880 Walker B motif; other site 272561000881 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272561000882 porphobilinogen deaminase; Provisional; Region: PRK01066 272561000883 Porphobilinogen deaminase [Coenzyme metabolism]; Region: HemC; COG0181 272561000884 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 272561000885 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272561000886 active site 272561000887 ATP binding site [chemical binding]; other site 272561000888 substrate binding site [chemical binding]; other site 272561000889 activation loop (A-loop); other site 272561000890 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 272561000891 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272561000892 active site 272561000893 HIGH motif; other site 272561000894 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272561000895 KMSKS motif; other site 272561000896 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272561000897 tRNA binding surface [nucleotide binding]; other site 272561000898 anticodon binding site; other site 272561000899 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 272561000900 V-type ATP synthase subunit K; Provisional; Region: PRK09621 272561000901 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 272561000902 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 272561000903 V-type ATP synthase subunit I; Validated; Region: PRK05771 272561000904 Protein of unknown function (DUF1319); Region: DUF1319; pfam07028 272561000905 V-type ATP synthase subunit D; Provisional; Region: PRK02195 272561000906 V-type ATP synthase subunit B; Provisional; Region: PRK02118 272561000907 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272561000908 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 272561000909 Walker A motif homologous position; other site 272561000910 Walker B motif; other site 272561000911 V-type ATP synthase subunit A; Provisional; Region: PRK04192 272561000912 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272561000913 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 272561000914 Walker A motif/ATP binding site; other site 272561000915 Walker B motif; other site 272561000916 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272561000917 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 272561000918 V-type ATP synthase subunit E; Provisional; Region: PRK01005 272561000919 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 272561000920 transaldolase-like protein; Provisional; Region: PTZ00411 272561000921 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 272561000922 active site 272561000923 dimer interface [polypeptide binding]; other site 272561000924 catalytic residue [active] 272561000925 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 272561000926 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 272561000927 beta and beta' interface [polypeptide binding]; other site 272561000928 beta' and sigma factor interface [polypeptide binding]; other site 272561000929 Zn-binding [ion binding]; other site 272561000930 active site region [active] 272561000931 catalytic site [active] 272561000932 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272561000933 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 272561000934 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272561000935 G-loop; other site 272561000936 DNA binding site [nucleotide binding] 272561000937 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272561000938 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272561000939 RPB12 interaction site [polypeptide binding]; other site 272561000940 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 272561000941 RPB1 interaction site [polypeptide binding]; other site 272561000942 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 272561000943 RPB10 interaction site [polypeptide binding]; other site 272561000944 RPB11 interaction site [polypeptide binding]; other site 272561000945 RPB3 interaction site [polypeptide binding]; other site 272561000946 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272561000947 core dimer interface [polypeptide binding]; other site 272561000948 peripheral dimer interface [polypeptide binding]; other site 272561000949 L10 interface [polypeptide binding]; other site 272561000950 L11 interface [polypeptide binding]; other site 272561000951 putative EF-Tu interaction site [polypeptide binding]; other site 272561000952 putative EF-G interaction site [polypeptide binding]; other site 272561000953 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272561000954 23S rRNA interface [nucleotide binding]; other site 272561000955 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272561000956 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272561000957 mRNA/rRNA interface [nucleotide binding]; other site 272561000958 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272561000959 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272561000960 putative thiostrepton binding site; other site 272561000961 23S rRNA interface [nucleotide binding]; other site 272561000962 L7/L12 interface [polypeptide binding]; other site 272561000963 L25 interface [polypeptide binding]; other site 272561000964 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272561000965 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 272561000966 putative homodimer interface [polypeptide binding]; other site 272561000967 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 272561000968 heterodimer interface [polypeptide binding]; other site 272561000969 homodimer interface [polypeptide binding]; other site 272561000970 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 272561000971 elongation factor Tu; Reviewed; Region: PRK12735 272561000972 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272561000973 G1 box; other site 272561000974 GEF interaction site [polypeptide binding]; other site 272561000975 GTP/Mg2+ binding site [chemical binding]; other site 272561000976 Switch I region; other site 272561000977 G2 box; other site 272561000978 G3 box; other site 272561000979 Switch II region; other site 272561000980 G4 box; other site 272561000981 G5 box; other site 272561000982 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272561000983 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272561000984 Antibiotic Binding Site [chemical binding]; other site 272561000985 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272561000986 rRNA binding site [nucleotide binding]; other site 272561000987 predicted 30S ribosome binding site; other site 272561000988 Colicin pore forming domain; Region: Colicin; pfam01024 272561000989 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 272561000990 Protein of unknown function (DUF687); Region: DUF687; pfam05095 272561000991 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 272561000992 active site 272561000993 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272561000994 substrate binding site [chemical binding]; other site 272561000995 dimer interface [polypeptide binding]; other site 272561000996 catalytic triad [active] 272561000997 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 272561000998 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 272561000999 generic binding surface II; other site 272561001000 generic binding surface I; other site 272561001001 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 272561001002 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272561001003 TPP-binding site; other site 272561001004 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272561001005 PYR/PP interface [polypeptide binding]; other site 272561001006 dimer interface [polypeptide binding]; other site 272561001007 TPP binding site [chemical binding]; other site 272561001008 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272561001009 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 272561001010 pyruvate kinase; Region: pyruv_kin; TIGR01064 272561001011 domain interfaces; other site 272561001012 active site 272561001013 excinuclease ABC subunit A; Provisional; Region: PRK00635 272561001014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272561001015 Walker A/P-loop; other site 272561001016 ATP binding site [chemical binding]; other site 272561001017 Q-loop/lid; other site 272561001018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272561001019 ABC transporter signature motif; other site 272561001020 Walker B; other site 272561001021 D-loop; other site 272561001022 H-loop/switch region; other site 272561001023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272561001024 Walker A/P-loop; other site 272561001025 ATP binding site [chemical binding]; other site 272561001026 Q-loop/lid; other site 272561001027 ABC transporter signature motif; other site 272561001028 Walker B; other site 272561001029 D-loop; other site 272561001030 H-loop/switch region; other site 272561001031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272561001032 Walker A/P-loop; other site 272561001033 ATP binding site [chemical binding]; other site 272561001034 Q-loop/lid; other site 272561001035 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272561001036 ABC transporter signature motif; other site 272561001037 Walker B; other site 272561001038 D-loop; other site 272561001039 H-loop/switch region; other site 272561001040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272561001041 Walker A/P-loop; other site 272561001042 ATP binding site [chemical binding]; other site 272561001043 Q-loop/lid; other site 272561001044 ABC transporter signature motif; other site 272561001045 Walker B; other site 272561001046 D-loop; other site 272561001047 H-loop/switch region; other site 272561001048 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 272561001049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272561001050 Walker A motif; other site 272561001051 ATP binding site [chemical binding]; other site 272561001052 Walker B motif; other site 272561001053 arginine finger; other site 272561001054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 272561001055 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 272561001056 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 272561001057 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272561001058 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272561001059 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272561001060 dimerization domain swap beta strand [polypeptide binding]; other site 272561001061 regulatory protein interface [polypeptide binding]; other site 272561001062 active site 272561001063 regulatory phosphorylation site [posttranslational modification]; other site 272561001064 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 272561001065 Competence protein; Region: Competence; pfam03772 272561001066 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272561001067 tetramer interface [polypeptide binding]; other site 272561001068 TPP-binding site [chemical binding]; other site 272561001069 heterodimer interface [polypeptide binding]; other site 272561001070 phosphorylation loop region [posttranslational modification] 272561001071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272561001072 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272561001073 alpha subunit interface [polypeptide binding]; other site 272561001074 TPP binding site [chemical binding]; other site 272561001075 heterodimer interface [polypeptide binding]; other site 272561001076 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272561001077 chaperone protein DnaJ; Provisional; Region: PRK14284 272561001078 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272561001079 HSP70 interaction site [polypeptide binding]; other site 272561001080 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272561001081 Zn binding sites [ion binding]; other site 272561001082 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272561001083 dimer interface [polypeptide binding]; other site 272561001084 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 272561001085 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 272561001086 Glycoprotease family; Region: Peptidase_M22; pfam00814 272561001087 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 272561001088 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 272561001089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272561001090 Walker A motif; other site 272561001091 ATP binding site [chemical binding]; other site 272561001092 Walker B motif; other site 272561001093 arginine finger; other site 272561001094 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272561001095 ribonuclease Z; Region: RNase_Z; TIGR02651 272561001096 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 272561001097 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272561001098 active site 272561001099 DNA binding site [nucleotide binding] 272561001100 Int/Topo IB signature motif; other site 272561001101 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272561001102 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272561001103 ABC transporter; Region: ABC_tran_2; pfam12848 272561001104 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272561001105 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 272561001106 active site 272561001107 dimer interface [polypeptide binding]; other site 272561001108 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 272561001109 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272561001110 active site 272561001111 catalytic residues [active] 272561001112 metal binding site [ion binding]; metal-binding site 272561001113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272561001114 S-adenosylmethionine binding site [chemical binding]; other site 272561001115 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 272561001116 Protein of unknown function, DUF255; Region: Thioredox_DsbH; pfam03190 272561001117 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 272561001118 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 272561001119 inhibitor site; inhibition site 272561001120 active site 272561001121 dimer interface [polypeptide binding]; other site 272561001122 catalytic residue [active] 272561001123 aspartate kinase; Provisional; Region: PRK05925 272561001124 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 272561001125 putative catalytic residues [active] 272561001126 nucleotide binding site [chemical binding]; other site 272561001127 aspartate binding site [chemical binding]; other site 272561001128 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 272561001129 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 272561001130 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 272561001131 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 272561001132 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 272561001133 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 272561001134 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 272561001135 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 272561001136 hinge; other site 272561001137 active site 272561001138 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 272561001139 shikimate kinase; Provisional; Region: PRK00625 272561001140 active site 272561001141 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 272561001142 Tetramer interface [polypeptide binding]; other site 272561001143 active site 272561001144 FMN-binding site [chemical binding]; other site 272561001145 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 272561001146 active site 272561001147 dimer interface [polypeptide binding]; other site 272561001148 metal binding site [ion binding]; metal-binding site 272561001149 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 272561001150 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 272561001151 active site 272561001152 catalytic residue [active] 272561001153 dimer interface [polypeptide binding]; other site 272561001154 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272561001155 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272561001156 shikimate binding site; other site 272561001157 NAD(P) binding site [chemical binding]; other site 272561001158 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 272561001159 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272561001160 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 272561001161 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 272561001162 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272561001163 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272561001164 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272561001165 malate dehydrogenase; Provisional; Region: PRK05442 272561001166 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 272561001167 NAD(P) binding site [chemical binding]; other site 272561001168 LDH/MDH dimer interface [polypeptide binding]; other site 272561001169 substrate binding site [chemical binding]; other site 272561001170 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 272561001171 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272561001172 active site 272561001173 dimer interface [polypeptide binding]; other site 272561001174 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 272561001175 dimer interface [polypeptide binding]; other site 272561001176 active site 272561001177 GTPases [General function prediction only]; Region: HflX; COG2262 272561001178 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 272561001179 HflX GTPase family; Region: HflX; cd01878 272561001180 G1 box; other site 272561001181 GTP/Mg2+ binding site [chemical binding]; other site 272561001182 Switch I region; other site 272561001183 G2 box; other site 272561001184 G3 box; other site 272561001185 Switch II region; other site 272561001186 G4 box; other site 272561001187 G5 box; other site 272561001188 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 272561001189 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 272561001190 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272561001191 substrate binding pocket [chemical binding]; other site 272561001192 membrane-bound complex binding site; other site 272561001193 hinge residues; other site 272561001194 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 272561001195 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 272561001196 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 272561001197 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 272561001198 nucleotide binding site/active site [active] 272561001199 Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286 272561001200 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 272561001201 hypothetical protein; Validated; Region: PRK00647 272561001202 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 272561001203 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 272561001204 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272561001205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272561001206 homodimer interface [polypeptide binding]; other site 272561001207 catalytic residue [active] 272561001208 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984 272561001209 prolyl-tRNA synthetase; Provisional; Region: PRK09194 272561001210 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 272561001211 dimer interface [polypeptide binding]; other site 272561001212 motif 1; other site 272561001213 active site 272561001214 motif 2; other site 272561001215 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 272561001216 putative deacylase active site [active] 272561001217 motif 3; other site 272561001218 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 272561001219 anticodon binding site; other site 272561001220 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 272561001221 HrcA protein C terminal domain; Region: HrcA; pfam01628 272561001222 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272561001223 dimer interface [polypeptide binding]; other site 272561001224 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272561001225 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272561001226 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 272561001227 nucleotide binding site [chemical binding]; other site 272561001228 NEF interaction site [polypeptide binding]; other site 272561001229 SBD interface [polypeptide binding]; other site 272561001230 Exoribonuclease R [Transcription]; Region: VacB; COG0557 272561001231 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 272561001232 RNB domain; Region: RNB; pfam00773 272561001233 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 272561001234 Putative zinc ribbon domain; Region: DUF164; pfam02591 272561001235 KpsF/GutQ family protein; Region: kpsF; TIGR00393 272561001236 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 272561001237 putative active site [active] 272561001238 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 272561001239 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 272561001240 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272561001241 E3 interaction surface; other site 272561001242 lipoyl attachment site [posttranslational modification]; other site 272561001243 e3 binding domain; Region: E3_binding; pfam02817 272561001244 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272561001245 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 272561001246 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 272561001247 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272561001248 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 272561001249 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272561001250 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 272561001251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272561001252 S-adenosylmethionine binding site [chemical binding]; other site 272561001253 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 272561001254 Lumazine binding domain; Region: Lum_binding; pfam00677 272561001255 Lumazine binding domain; Region: Lum_binding; pfam00677 272561001256 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 272561001257 ATP cone domain; Region: ATP-cone; pfam03477 272561001258 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 272561001259 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 272561001260 amino acid carrier protein; Region: agcS; TIGR00835 272561001261 poly(A) polymerase; Region: pcnB; TIGR01942 272561001262 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272561001263 active site 272561001264 NTP binding site [chemical binding]; other site 272561001265 metal binding triad [ion binding]; metal-binding site 272561001266 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272561001267 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 272561001268 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 272561001269 Predicted membrane protein [Function unknown]; Region: COG3952 272561001270 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 272561001271 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 272561001272 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 272561001273 Autotransporter beta-domain; Region: Autotransporter; pfam03797 272561001274 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 272561001275 Autotransporter beta-domain; Region: Autotransporter; pfam03797 272561001276 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 272561001277 Autotransporter beta-domain; Region: Autotransporter; pfam03797 272561001278 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272561001279 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272561001280 intersubunit interface [polypeptide binding]; other site 272561001281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272561001282 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272561001283 Walker A/P-loop; other site 272561001284 ATP binding site [chemical binding]; other site 272561001285 Q-loop/lid; other site 272561001286 ABC transporter signature motif; other site 272561001287 Walker B; other site 272561001288 D-loop; other site 272561001289 H-loop/switch region; other site 272561001290 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272561001291 ABC-ATPase subunit interface; other site 272561001292 dimer interface [polypeptide binding]; other site 272561001293 putative PBP binding regions; other site 272561001294 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 272561001295 GTP1/OBG; Region: GTP1_OBG; pfam01018 272561001296 Obg GTPase; Region: Obg; cd01898 272561001297 G1 box; other site 272561001298 GTP/Mg2+ binding site [chemical binding]; other site 272561001299 Switch I region; other site 272561001300 G2 box; other site 272561001301 G3 box; other site 272561001302 Switch II region; other site 272561001303 G4 box; other site 272561001304 G5 box; other site 272561001305 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 272561001306 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 272561001307 Uncharacterized conserved protein [Function unknown]; Region: COG2928 272561001308 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 272561001309 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 272561001310 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272561001311 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272561001312 Transporter associated domain; Region: CorC_HlyC; smart01091 272561001313 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272561001314 anti sigma factor interaction site; other site 272561001315 regulatory phosphorylation site [posttranslational modification]; other site 272561001316 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 272561001317 hypothetical protein; Provisional; Region: PRK05926 272561001318 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272561001319 FeS/SAM binding site; other site 272561001320 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 272561001321 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 272561001322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272561001323 S-adenosylmethionine binding site [chemical binding]; other site 272561001324 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 272561001325 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 272561001326 diaminopimelate epimerase; Region: DapF; TIGR00652 272561001327 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 272561001328 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 272561001329 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272561001330 oligomer interface [polypeptide binding]; other site 272561001331 active site residues [active] 272561001332 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272561001333 dimer interface [polypeptide binding]; other site 272561001334 active site 272561001335 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272561001336 folate binding site [chemical binding]; other site 272561001337 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 272561001338 active site 272561001339 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 272561001340 homotrimer interaction site [polypeptide binding]; other site 272561001341 zinc binding site [ion binding]; other site 272561001342 CDP-binding sites; other site 272561001343 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 272561001344 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 272561001345 FAD binding pocket [chemical binding]; other site 272561001346 conserved FAD binding motif [chemical binding]; other site 272561001347 phosphate binding motif [ion binding]; other site 272561001348 beta-alpha-beta structure motif; other site 272561001349 NAD binding pocket [chemical binding]; other site 272561001350 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 272561001351 elongation factor G; Reviewed; Region: PRK12739 272561001352 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272561001353 G1 box; other site 272561001354 putative GEF interaction site [polypeptide binding]; other site 272561001355 GTP/Mg2+ binding site [chemical binding]; other site 272561001356 Switch I region; other site 272561001357 G2 box; other site 272561001358 G3 box; other site 272561001359 Switch II region; other site 272561001360 G4 box; other site 272561001361 G5 box; other site 272561001362 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272561001363 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272561001364 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272561001365 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272561001366 30S ribosomal protein S7; Validated; Region: PRK05302 272561001367 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272561001368 S17 interaction site [polypeptide binding]; other site 272561001369 S8 interaction site; other site 272561001370 16S rRNA interaction site [nucleotide binding]; other site 272561001371 streptomycin interaction site [chemical binding]; other site 272561001372 23S rRNA interaction site [nucleotide binding]; other site 272561001373 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272561001374 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 272561001375 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 272561001376 protein binding site [polypeptide binding]; other site 272561001377 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 272561001378 Catalytic dyad [active] 272561001379 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 272561001380 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 272561001381 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 272561001382 Domain of unknown function DUF11; Region: DUF11; pfam01345 272561001383 Domain of unknown function DUF11; Region: DUF11; pfam01345 272561001384 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 272561001385 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 272561001386 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272561001387 active site 272561001388 HIGH motif; other site 272561001389 KMSKS motif; other site 272561001390 Helix-turn-helix domain; Region: HTH_17; pfam12728 272561001391 Helix-turn-helix domain; Region: HTH_17; pfam12728 272561001392 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 272561001393 DHH family; Region: DHH; pfam01368 272561001394 DHHA1 domain; Region: DHHA1; pfam02272 272561001395 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 272561001396 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 272561001397 Protein export membrane protein; Region: SecD_SecF; pfam02355 272561001398 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 272561001399 active site 272561001400 dimer interface [polypeptide binding]; other site 272561001401 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 272561001402 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 272561001403 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272561001404 CMP-binding site; other site 272561001405 The sites determining sugar specificity; other site 272561001406 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272561001407 putative acyl-acceptor binding pocket; other site 272561001408 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 272561001409 arginine-tRNA ligase; Region: PLN02286 272561001410 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272561001411 active site 272561001412 HIGH motif; other site 272561001413 KMSK motif region; other site 272561001414 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272561001415 tRNA binding surface [nucleotide binding]; other site 272561001416 anticodon binding site; other site 272561001417 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 272561001418 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272561001419 hinge; other site 272561001420 active site 272561001421 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 272561001422 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 272561001423 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 272561001424 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 272561001425 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272561001426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272561001427 Coenzyme A binding pocket [chemical binding]; other site 272561001428 peptide chain release factor 2; Validated; Region: prfB; PRK00578 272561001429 PCRF domain; Region: PCRF; pfam03462 272561001430 RF-1 domain; Region: RF-1; pfam00472 272561001431 SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531 272561001432 SWI complex, BAF60b domains; Region: SWIB; smart00151 272561001433 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 272561001434 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272561001435 putative active site [active] 272561001436 putative metal binding site [ion binding]; other site 272561001437 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 272561001438 substrate binding site; other site 272561001439 dimer interface; other site 272561001440 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 272561001441 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 272561001442 dimerization interface 3.5A [polypeptide binding]; other site 272561001443 active site 272561001444 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272561001445 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272561001446 active site 272561001447 motif I; other site 272561001448 motif II; other site 272561001449 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 272561001450 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272561001451 putative active site [active] 272561001452 heme pocket [chemical binding]; other site 272561001453 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272561001454 dimer interface [polypeptide binding]; other site 272561001455 phosphorylation site [posttranslational modification] 272561001456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272561001457 ATP binding site [chemical binding]; other site 272561001458 Mg2+ binding site [ion binding]; other site 272561001459 G-X-G motif; other site 272561001460 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272561001461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272561001462 active site 272561001463 phosphorylation site [posttranslational modification] 272561001464 intermolecular recognition site; other site 272561001465 dimerization interface [polypeptide binding]; other site 272561001466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272561001467 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272561001468 Walker A motif; other site 272561001469 ATP binding site [chemical binding]; other site 272561001470 Walker B motif; other site 272561001471 arginine finger; other site 272561001472 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 272561001473 Recombination protein O N terminal; Region: RecO_N; pfam11967 272561001474 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 272561001475 Recombination protein O C terminal; Region: RecO_C; pfam02565 272561001476 Uncharacterized conserved protein [Function unknown]; Region: COG1723 272561001477 hypothetical protein; Provisional; Region: PRK14377 272561001478 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 272561001479 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272561001480 putative tRNA-binding site [nucleotide binding]; other site 272561001481 B3/4 domain; Region: B3_4; pfam03483 272561001482 tRNA synthetase B5 domain; Region: B5; pfam03484 272561001483 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 272561001484 dimer interface [polypeptide binding]; other site 272561001485 motif 1; other site 272561001486 motif 3; other site 272561001487 motif 2; other site 272561001488 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 272561001489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 272561001490 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272561001491 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272561001492 DNA binding site [nucleotide binding] 272561001493 active site 272561001494 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272561001495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272561001496 dimer interface [polypeptide binding]; other site 272561001497 conserved gate region; other site 272561001498 putative PBP binding loops; other site 272561001499 ABC-ATPase subunit interface; other site 272561001500 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272561001501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272561001502 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272561001503 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 272561001504 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272561001505 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 272561001506 putative active site [active] 272561001507 putative metal binding site [ion binding]; other site 272561001508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272561001509 binding surface 272561001510 TPR motif; other site 272561001511 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 272561001512 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 272561001513 C-terminal domain interface [polypeptide binding]; other site 272561001514 active site 272561001515 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 272561001516 active site 272561001517 N-terminal domain interface [polypeptide binding]; other site 272561001518 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 272561001519 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272561001520 substrate binding pocket [chemical binding]; other site 272561001521 membrane-bound complex binding site; other site 272561001522 hinge residues; other site 272561001523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272561001524 S-adenosylmethionine binding site [chemical binding]; other site 272561001525 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 272561001526 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 272561001527 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 272561001528 ligand binding site; other site 272561001529 oligomer interface; other site 272561001530 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 272561001531 N-terminal domain interface [polypeptide binding]; other site 272561001532 sulfate 1 binding site; other site 272561001533 transcription termination factor Rho; Region: rho; TIGR00767 272561001534 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 272561001535 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 272561001536 RNA binding site [nucleotide binding]; other site 272561001537 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 272561001538 multimer interface [polypeptide binding]; other site 272561001539 Walker A motif; other site 272561001540 ATP binding site [chemical binding]; other site 272561001541 Walker B motif; other site 272561001542 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 272561001543 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272561001544 CoA-binding site [chemical binding]; other site 272561001545 ATP-binding [chemical binding]; other site 272561001546 DNA polymerase I; Provisional; Region: PRK05755 272561001547 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272561001548 active site 272561001549 metal binding site 1 [ion binding]; metal-binding site 272561001550 putative 5' ssDNA interaction site; other site 272561001551 metal binding site 3; metal-binding site 272561001552 metal binding site 2 [ion binding]; metal-binding site 272561001553 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272561001554 putative DNA binding site [nucleotide binding]; other site 272561001555 putative metal binding site [ion binding]; other site 272561001556 3'-5' exonuclease; Region: 35EXOc; smart00474 272561001557 active site 272561001558 substrate binding site [chemical binding]; other site 272561001559 catalytic site [active] 272561001560 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 272561001561 active site 272561001562 DNA binding site [nucleotide binding] 272561001563 catalytic site [active] 272561001564 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 272561001565 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 272561001566 tandem repeat interface [polypeptide binding]; other site 272561001567 oligomer interface [polypeptide binding]; other site 272561001568 active site residues [active] 272561001569 TLC ATP/ADP transporter; Region: TLC; pfam03219 272561001570 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 272561001571 replicative DNA helicase; Provisional; Region: PRK06321 272561001572 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272561001573 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272561001574 Walker A motif; other site 272561001575 ATP binding site [chemical binding]; other site 272561001576 Walker B motif; other site 272561001577 DNA binding loops [nucleotide binding] 272561001578 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272561001579 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272561001580 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 272561001581 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 272561001582 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 272561001583 Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; Region: NDK; smart00562 272561001584 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 272561001585 active site 272561001586 multimer interface [polypeptide binding]; other site 272561001587 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 272561001588 RuvA N terminal domain; Region: RuvA_N; pfam01330 272561001589 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272561001590 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 272561001591 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 272561001592 active site 272561001593 putative DNA-binding cleft [nucleotide binding]; other site 272561001594 dimer interface [polypeptide binding]; other site 272561001595 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 272561001596 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 272561001597 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272561001598 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272561001599 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 272561001600 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 272561001601 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272561001602 alphaNTD - beta interaction site [polypeptide binding]; other site 272561001603 alphaNTD homodimer interface [polypeptide binding]; other site 272561001604 alphaNTD - beta' interaction site [polypeptide binding]; other site 272561001605 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 272561001606 30S ribosomal protein S11; Validated; Region: PRK05309 272561001607 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 272561001608 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272561001609 SecY translocase; Region: SecY; pfam00344 272561001610 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 272561001611 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 272561001612 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272561001613 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272561001614 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272561001615 5S rRNA interface [nucleotide binding]; other site 272561001616 L27 interface [polypeptide binding]; other site 272561001617 23S rRNA interface [nucleotide binding]; other site 272561001618 L5 interface [polypeptide binding]; other site 272561001619 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272561001620 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272561001621 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272561001622 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 272561001623 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272561001624 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272561001625 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272561001626 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 272561001627 RNA binding site [nucleotide binding]; other site 272561001628 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 272561001629 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 272561001630 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272561001631 23S rRNA interface [nucleotide binding]; other site 272561001632 putative translocon interaction site; other site 272561001633 signal recognition particle (SRP54) interaction site; other site 272561001634 L23 interface [polypeptide binding]; other site 272561001635 trigger factor interaction site; other site 272561001636 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272561001637 23S rRNA interface [nucleotide binding]; other site 272561001638 5S rRNA interface [nucleotide binding]; other site 272561001639 putative antibiotic binding site [chemical binding]; other site 272561001640 L25 interface [polypeptide binding]; other site 272561001641 L27 interface [polypeptide binding]; other site 272561001642 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 272561001643 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272561001644 G-X-X-G motif; other site 272561001645 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272561001646 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272561001647 putative translocon binding site; other site 272561001648 protein-rRNA interface [nucleotide binding]; other site 272561001649 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 272561001650 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272561001651 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272561001652 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272561001653 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 272561001654 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 272561001655 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 272561001656 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 272561001657 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272561001658 putative active site [active] 272561001659 substrate binding site [chemical binding]; other site 272561001660 putative cosubstrate binding site; other site 272561001661 catalytic site [active] 272561001662 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272561001663 substrate binding site [chemical binding]; other site 272561001664 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 272561001665 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 272561001666 active site 272561001667 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272561001668 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 272561001669 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 272561001670 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 272561001671 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 272561001672 putative active site [active] 272561001673 catalytic triad [active] 272561001674 putative dimer interface [polypeptide binding]; other site 272561001675 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 272561001676 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 272561001677 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272561001678 active site 272561001679 catalytic site [active] 272561001680 substrate binding site [chemical binding]; other site 272561001681 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 272561001682 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 272561001683 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 272561001684 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272561001685 catalytic residues [active] 272561001686 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 272561001687 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 272561001688 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 272561001689 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272561001690 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272561001691 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272561001692 dimer interface [polypeptide binding]; other site 272561001693 anticodon binding site; other site 272561001694 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 272561001695 homodimer interface [polypeptide binding]; other site 272561001696 motif 1; other site 272561001697 active site 272561001698 motif 2; other site 272561001699 GAD domain; Region: GAD; pfam02938 272561001700 motif 3; other site 272561001701 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 272561001702 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272561001703 dimer interface [polypeptide binding]; other site 272561001704 motif 1; other site 272561001705 active site 272561001706 motif 2; other site 272561001707 motif 3; other site 272561001708 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 272561001709 anticodon binding site; other site 272561001710 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 272561001711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272561001712 putative substrate translocation pore; other site 272561001713 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 272561001714 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 272561001715 active site 272561001716 PHP Thumb interface [polypeptide binding]; other site 272561001717 metal binding site [ion binding]; metal-binding site 272561001718 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272561001719 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 272561001720 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272561001721 generic binding surface I; other site 272561001722 generic binding surface II; other site 272561001723 TPR repeat; Region: TPR_11; pfam13414 272561001724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272561001725 binding surface 272561001726 TPR motif; other site 272561001727 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 272561001728 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 272561001729 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272561001730 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 272561001731 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 272561001732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272561001733 S-adenosylmethionine binding site [chemical binding]; other site 272561001734 branched-chain amino acid uptake carrier; Region: livcs; TIGR00796 272561001735 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 272561001736 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272561001737 ATP binding site [chemical binding]; other site 272561001738 putative Mg++ binding site [ion binding]; other site 272561001739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272561001740 ATP-binding site [chemical binding]; other site 272561001741 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 272561001742 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272561001743 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272561001744 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272561001745 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272561001746 lipoate synthase; Region: lipA; TIGR00510 272561001747 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272561001748 FeS/SAM binding site; other site 272561001749 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 272561001750 type III secretion system protein; Validated; Region: PRK06328 272561001751 Flagellar assembly protein FliH; Region: FliH; pfam02108 272561001752 type III secretion system protein; Reviewed; Region: PRK09617 272561001753 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 272561001754 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 272561001755 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 272561001756 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 272561001757 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 272561001758 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272561001759 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272561001760 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 272561001761 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 272561001762 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 272561001763 Walker A motif; other site 272561001764 ATP binding site [chemical binding]; other site 272561001765 Walker B motif; other site 272561001766 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 272561001767 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 272561001768 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 272561001769 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272561001770 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272561001771 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272561001772 active site 272561001773 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 272561001774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272561001775 ATP binding site [chemical binding]; other site 272561001776 Mg2+ binding site [ion binding]; other site 272561001777 G-X-G motif; other site 272561001778 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 272561001779 ATP binding site [chemical binding]; other site 272561001780 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 272561001781 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 272561001782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272561001783 binding surface 272561001784 TPR motif; other site 272561001785 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 272561001786 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272561001787 EamA-like transporter family; Region: EamA; pfam00892 272561001788 EamA-like transporter family; Region: EamA; pfam00892 272561001789 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 272561001790 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cd01616 272561001791 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272561001792 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272561001793 active site 272561001794 dimer interface [polypeptide binding]; other site 272561001795 motif 1; other site 272561001796 motif 2; other site 272561001797 motif 3; other site 272561001798 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272561001799 anticodon binding site; other site 272561001800 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272561001801 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272561001802 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272561001803 P-loop; other site 272561001804 Magnesium ion binding site [ion binding]; other site 272561001805 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 272561001806 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 272561001807 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272561001808 active site 272561001809 HIGH motif; other site 272561001810 dimer interface [polypeptide binding]; other site 272561001811 KMSKS motif; other site 272561001812 excinuclease ABC subunit B; Provisional; Region: PRK05298 272561001813 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272561001814 ATP binding site [chemical binding]; other site 272561001815 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272561001816 nucleotide binding region [chemical binding]; other site 272561001817 ATP-binding site [chemical binding]; other site 272561001818 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272561001819 UvrB/uvrC motif; Region: UVR; pfam02151 272561001820 phosphopyruvate hydratase; Region: eno; TIGR01060 272561001821 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272561001822 dimer interface [polypeptide binding]; other site 272561001823 metal binding site [ion binding]; metal-binding site 272561001824 substrate binding pocket [chemical binding]; other site 272561001825 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 272561001826 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272561001827 dimerization interface [polypeptide binding]; other site 272561001828 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 272561001829 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 272561001830 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 272561001831 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 272561001832 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 272561001833 L-aspartate oxidase; Provisional; Region: PRK06175 272561001834 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 272561001835 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272561001836 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 272561001837 Iron-sulfur protein interface; other site 272561001838 proximal heme binding site [chemical binding]; other site 272561001839 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 272561001840 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272561001841 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 272561001842 active site 272561001843 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 272561001844 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 272561001845 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 272561001846 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 272561001847 DsbD alpha interface [polypeptide binding]; other site 272561001848 catalytic residues [active] 272561001849 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 272561001850 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 272561001851 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297 272561001852 translocation protein TolB; Provisional; Region: tolB; PRK01029 272561001853 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272561001854 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272561001855 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272561001856 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 272561001857 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272561001858 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272561001859 ligand binding site [chemical binding]; other site 272561001860 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 272561001861 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272561001862 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272561001863 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 272561001864 dimer interface [polypeptide binding]; other site 272561001865 decamer (pentamer of dimers) interface [polypeptide binding]; other site 272561001866 catalytic triad [active] 272561001867 peroxidatic and resolving cysteines [active] 272561001868 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 272561001869 chaperonin GroEL; Reviewed; Region: groEL; PRK12851 272561001870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 272561001871 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 272561001872 active site 272561001873 dimerization interface [polypeptide binding]; other site 272561001874 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 272561001875 ligand binding site [chemical binding]; other site 272561001876 active site 272561001877 UGI interface [polypeptide binding]; other site 272561001878 catalytic site [active] 272561001879 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 272561001880 Part of AAA domain; Region: AAA_19; pfam13245 272561001881 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272561001882 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 272561001883 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 272561001884 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 272561001885 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 272561001886 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 272561001887 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 272561001888 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272561001889 folate binding site [chemical binding]; other site 272561001890 NADP+ binding site [chemical binding]; other site 272561001891 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 272561001892 catalytic center binding site [active] 272561001893 ATP binding site [chemical binding]; other site 272561001894 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 272561001895 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 272561001896 substrate binding pocket [chemical binding]; other site 272561001897 dimer interface [polypeptide binding]; other site 272561001898 inhibitor binding site; inhibition site 272561001899 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 272561001900 homooctamer interface [polypeptide binding]; other site 272561001901 active site 272561001902 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 272561001903 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 272561001904 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272561001905 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272561001906 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272561001907 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272561001908 DNA binding residues [nucleotide binding] 272561001909 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 272561001910 Ribosomal protein S20 [Translation, ribosomal structure and biogenesis]; Region: RpsT; COG0268 272561001911 Effector from type III secretion system; Region: Effector_1; pfam04518 272561001912 Effector from type III secretion system; Region: Effector_1; pfam04518 272561001913 Effector from type III secretion system; Region: Effector_1; pfam04518 272561001914 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 272561001915 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 272561001916 MviN-like protein; Region: MVIN; pfam03023 272561001917 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 272561001918 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 272561001919 AP (apurinic/apyrimidinic) site pocket; other site 272561001920 DNA interaction; other site 272561001921 Metal-binding active site; metal-binding site 272561001922 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272561001923 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 272561001924 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272561001925 RNA binding surface [nucleotide binding]; other site 272561001926 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 272561001927 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 272561001928 active site residue [active] 272561001929 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272561001930 substrate binding pocket [chemical binding]; other site 272561001931 aspartate-rich region 2; other site 272561001932 substrate-Mg2+ binding site; other site 272561001933 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272561001934 putative trimer interface [polypeptide binding]; other site 272561001935 putative CoA binding site [chemical binding]; other site 272561001936 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272561001937 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 272561001938 DNA binding site [nucleotide binding] 272561001939 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 272561001940 Thymidylate synthase complementing protein; Region: Thy1; cl03630 272561001941 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 272561001942 dimer interface [polypeptide binding]; other site 272561001943 allosteric magnesium binding site [ion binding]; other site 272561001944 active site 272561001945 aspartate-rich active site metal binding site; other site 272561001946 Schiff base residues; other site 272561001947 NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit; Region: nqrA; TIGR01936 272561001948 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 272561001949 Putative bacteriophage terminase small subunit; Region: Phage_term_sma; pfam07141 272561001950 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 272561001951 Uncharacterized N-terminal domain of the transcription elongation factor GreA [Function unknown]; Region: COG1747 272561001952 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272561001953 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272561001954 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 272561001955 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272561001956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272561001957 homodimer interface [polypeptide binding]; other site 272561001958 catalytic residue [active] 272561001959 rod shape-determining protein MreC; Region: MreC; cl19252 272561001960 rod shape-determining protein MreC; Region: MreC; cl19252 272561001961 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 272561001962 Part of AAA domain; Region: AAA_19; pfam13245 272561001963 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272561001964 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 272561001965 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 272561001966 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272561001967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272561001968 putative substrate translocation pore; other site 272561001969 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 272561001970 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272561001971 active site 272561001972 interdomain interaction site; other site 272561001973 putative metal-binding site [ion binding]; other site 272561001974 nucleotide binding site [chemical binding]; other site 272561001975 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272561001976 domain I; other site 272561001977 DNA binding groove [nucleotide binding] 272561001978 phosphate binding site [ion binding]; other site 272561001979 domain II; other site 272561001980 domain III; other site 272561001981 nucleotide binding site [chemical binding]; other site 272561001982 catalytic site [active] 272561001983 domain IV; other site 272561001984 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272561001985 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272561001986 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272561001987 SWI complex, BAF60b domains; Region: SWIB; smart00151 272561001988 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 272561001989 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272561001990 FMN binding site [chemical binding]; other site 272561001991 active site 272561001992 catalytic residues [active] 272561001993 substrate binding site [chemical binding]; other site 272561001994 Predicted integral membrane protein [Function unknown]; Region: COG0762 272561001995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 272561001996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 272561001997 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 272561001998 recombinase A; Provisional; Region: recA; PRK09354 272561001999 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 272561002000 hexamer interface [polypeptide binding]; other site 272561002001 Walker A motif; other site 272561002002 ATP binding site [chemical binding]; other site 272561002003 Walker B motif; other site 272561002004 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 272561002005 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 272561002006 AAA domain; Region: AAA_30; pfam13604 272561002007 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272561002008 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 272561002009 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 272561002010 Walker A/P-loop; other site 272561002011 ATP binding site [chemical binding]; other site 272561002012 Q-loop/lid; other site 272561002013 ABC transporter signature motif; other site 272561002014 Walker B; other site 272561002015 D-loop; other site 272561002016 H-loop/switch region; other site 272561002017 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 272561002018 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 272561002019 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272561002020 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272561002021 RNA binding surface [nucleotide binding]; other site 272561002022 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272561002023 active site 272561002024 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409 272561002025 G-X-X-G motif; other site 272561002026 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 272561002027 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272561002028 CAP-like domain; other site 272561002029 active site 272561002030 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 272561002031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272561002032 ATP binding site [chemical binding]; other site 272561002033 Mg2+ binding site [ion binding]; other site 272561002034 G-X-G motif; other site 272561002035 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272561002036 anchoring element; other site 272561002037 dimer interface [polypeptide binding]; other site 272561002038 ATP binding site [chemical binding]; other site 272561002039 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 272561002040 active site 272561002041 putative metal-binding site [ion binding]; other site 272561002042 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272561002043 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 272561002044 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 272561002045 NAD(P) binding pocket [chemical binding]; other site 272561002046 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 272561002047 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272561002048 phosphopeptide binding site; other site 272561002049 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 272561002050 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 272561002051 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 272561002052 phosphopeptide binding site; other site 272561002053 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272561002054 binding surface 272561002055 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272561002056 TPR motif; other site 272561002057 type III secretion system ATPase; Provisional; Region: PRK06315 272561002058 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272561002059 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 272561002060 Walker A motif/ATP binding site; other site 272561002061 Walker B motif; other site 272561002062 Autophagy protein Apg6; Region: APG6; pfam04111 272561002063 type III secretion system protein; Validated; Region: PRK05933 272561002064 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 272561002065 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272561002066 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272561002067 active site 272561002068 ATP binding site [chemical binding]; other site 272561002069 substrate binding site [chemical binding]; other site 272561002070 activation loop (A-loop); other site 272561002071 MAP7 (E-MAP-115) family; Region: MAP7; pfam05672 272561002072 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 272561002073 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 272561002074 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 272561002075 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 272561002076 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 272561002077 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 272561002078 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 272561002079 ADP binding site [chemical binding]; other site 272561002080 phosphagen binding site; other site 272561002081 substrate specificity loop; other site 272561002082 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 272561002083 UvrB/uvrC motif; Region: UVR; pfam02151 272561002084 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 272561002085 hinge region; other site 272561002086 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 272561002087 putative nucleotide binding site [chemical binding]; other site 272561002088 uridine monophosphate binding site [chemical binding]; other site 272561002089 homohexameric interface [polypeptide binding]; other site 272561002090 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 272561002091 UBA/TS-N domain; Region: UBA; pfam00627 272561002092 40S ribosomal protein SA; Provisional; Region: PTZ00254 272561002093 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272561002094 rRNA interaction site [nucleotide binding]; other site 272561002095 S8 interaction site; other site 272561002096 putative laminin-1 binding site; other site 272561002097 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 272561002098 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272561002099 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272561002100 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272561002101 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272561002102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272561002103 TPR motif; other site 272561002104 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272561002105 binding surface 272561002106 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272561002107 binding surface 272561002108 TPR motif; other site 272561002109 TPR repeat; Region: TPR_11; pfam13414 272561002110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272561002111 binding surface 272561002112 TPR repeat; Region: TPR_11; pfam13414 272561002113 TPR motif; other site 272561002114 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 272561002115 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 272561002116 FeS assembly ATPase SufC; Region: sufC; TIGR01978 272561002117 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 272561002118 Walker A/P-loop; other site 272561002119 ATP binding site [chemical binding]; other site 272561002120 Q-loop/lid; other site 272561002121 ABC transporter signature motif; other site 272561002122 Walker B; other site 272561002123 D-loop; other site 272561002124 H-loop/switch region; other site 272561002125 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 272561002126 FeS assembly protein SufD; Region: sufD; TIGR01981 272561002127 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 272561002128 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272561002129 catalytic residue [active] 272561002130 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 272561002131 ParB-like nuclease domain; Region: ParBc; pfam02195 272561002132 KorB domain; Region: KorB; pfam08535 272561002133 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272561002134 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272561002135 Walker A/P-loop; other site 272561002136 ATP binding site [chemical binding]; other site 272561002137 Q-loop/lid; other site 272561002138 ABC transporter signature motif; other site 272561002139 Walker B; other site 272561002140 D-loop; other site 272561002141 H-loop/switch region; other site 272561002142 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272561002143 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272561002144 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272561002145 Walker A/P-loop; other site 272561002146 ATP binding site [chemical binding]; other site 272561002147 Q-loop/lid; other site 272561002148 ABC transporter signature motif; other site 272561002149 Walker B; other site 272561002150 D-loop; other site 272561002151 H-loop/switch region; other site 272561002152 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272561002153 TIGR00153 family protein; Region: TIGR00153 272561002154 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 272561002155 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 272561002156 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 272561002157 substrate binding site [chemical binding]; other site 272561002158 hinge regions; other site 272561002159 ADP binding site [chemical binding]; other site 272561002160 catalytic site [active] 272561002161 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 272561002162 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272561002163 minor groove reading motif; other site 272561002164 helix-hairpin-helix signature motif; other site 272561002165 substrate binding pocket [chemical binding]; other site 272561002166 active site 272561002167 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 272561002168 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272561002169 trmE is a tRNA modification GTPase; Region: trmE; cd04164 272561002170 G1 box; other site 272561002171 GTP/Mg2+ binding site [chemical binding]; other site 272561002172 Switch I region; other site 272561002173 G2 box; other site 272561002174 Switch II region; other site 272561002175 G3 box; other site 272561002176 G4 box; other site 272561002177 G5 box; other site 272561002178 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272561002179 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 272561002180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272561002181 binding surface 272561002182 TPR motif; other site 272561002183 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 272561002184 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272561002185 ATP binding site [chemical binding]; other site 272561002186 putative Mg++ binding site [ion binding]; other site 272561002187 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 272561002188 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272561002189 nucleotide binding region [chemical binding]; other site 272561002190 ATP-binding site [chemical binding]; other site 272561002191 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 272561002192 Predicted GTPases [General function prediction only]; Region: COG1160 272561002193 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272561002194 G1 box; other site 272561002195 GTP/Mg2+ binding site [chemical binding]; other site 272561002196 Switch I region; other site 272561002197 G2 box; other site 272561002198 Switch II region; other site 272561002199 G3 box; other site 272561002200 G4 box; other site 272561002201 G5 box; other site 272561002202 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272561002203 G1 box; other site 272561002204 GTP/Mg2+ binding site [chemical binding]; other site 272561002205 Switch I region; other site 272561002206 G2 box; other site 272561002207 G3 box; other site 272561002208 Switch II region; other site 272561002209 G4 box; other site 272561002210 G5 box; other site 272561002211 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 272561002212 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 272561002213 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272561002214 active site 272561002215 NTP binding site [chemical binding]; other site 272561002216 metal binding triad [ion binding]; metal-binding site 272561002217 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272561002218 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 272561002219 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 272561002220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272561002221 Walker A motif; other site 272561002222 ATP binding site [chemical binding]; other site 272561002223 Walker B motif; other site 272561002224 arginine finger; other site 272561002225 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272561002226 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272561002227 oligomer interface [polypeptide binding]; other site 272561002228 active site residues [active] 272561002229 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 272561002230 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 272561002231 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272561002232 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 272561002233 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 272561002234 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272561002235 ATP binding site [chemical binding]; other site 272561002236 putative Mg++ binding site [ion binding]; other site 272561002237 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272561002238 nucleotide binding region [chemical binding]; other site 272561002239 ATP-binding site [chemical binding]; other site 272561002240 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 272561002241 MreB and similar proteins; Region: MreB_like; cd10225 272561002242 nucleotide binding site [chemical binding]; other site 272561002243 Mg binding site [ion binding]; other site 272561002244 putative protofilament interaction site [polypeptide binding]; other site 272561002245 RodZ interaction site [polypeptide binding]; other site 272561002246 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 272561002247 active site 272561002248 substrate-binding site [chemical binding]; other site 272561002249 metal-binding site [ion binding] 272561002250 GTP binding site [chemical binding]; other site 272561002251 Effector from type III secretion system; Region: Effector_1; pfam04518 272561002252 Effector from type III secretion system; Region: Effector_1; pfam04518 272561002253 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 272561002254 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 272561002255 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272561002256 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272561002257 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 272561002258 active site 272561002259 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 272561002260 type III secretion system ATPase; Validated; Region: PRK05922 272561002261 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272561002262 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272561002263 Walker A motif; other site 272561002264 ATP binding site [chemical binding]; other site 272561002265 Walker B motif; other site 272561002266 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 272561002267 type III secretion system protein; Validated; Region: PRK05934 272561002268 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 272561002269 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 272561002270 active site 272561002271 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 272561002272 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272561002273 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272561002274 catalytic residue [active] 272561002275 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272561002276 catalytic core [active] 272561002277 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272561002278 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272561002279 RNA binding surface [nucleotide binding]; other site 272561002280 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 272561002281 active site 272561002282 biotin--protein ligase; Provisional; Region: PRK05935 272561002283 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 272561002284 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 272561002285 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 272561002286 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272561002287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272561002288 motif II; other site 272561002289 CCC1-related protein family; Region: CCC1_like_1; cd02437 272561002290 seryl-tRNA synthetase; Provisional; Region: PRK05431 272561002291 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272561002292 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 272561002293 dimer interface [polypeptide binding]; other site 272561002294 active site 272561002295 motif 1; other site 272561002296 motif 2; other site 272561002297 motif 3; other site 272561002298 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 272561002299 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 272561002300 catalytic motif [active] 272561002301 Zn binding site [ion binding]; other site 272561002302 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 272561002303 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 272561002304 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 272561002305 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 272561002306 dimerization interface [polypeptide binding]; other site 272561002307 active site 272561002308 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 272561002309 homopentamer interface [polypeptide binding]; other site 272561002310 active site 272561002311 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 272561002312 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 272561002313 substrate binding site [chemical binding]; other site 272561002314 Proteins containing SET domain [General function prediction only]; Region: COG2940 272561002315 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 272561002316 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 272561002317 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 272561002318 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 272561002319 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272561002320 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 272561002321 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 272561002322 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272561002323 catalytic loop [active] 272561002324 iron binding site [ion binding]; other site 272561002325 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 272561002326 FAD binding pocket [chemical binding]; other site 272561002327 FAD binding motif [chemical binding]; other site 272561002328 phosphate binding motif [ion binding]; other site 272561002329 beta-alpha-beta structure motif; other site 272561002330 NAD binding pocket [chemical binding]; other site 272561002331 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 272561002332 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 272561002333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272561002334 S-adenosylmethionine binding site [chemical binding]; other site 272561002335 Histone H1-like protein Hc1; Region: Hc1; pfam07432 272561002336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272561002337 binding surface 272561002338 TPR motif; other site 272561002339 Tetratricopeptide repeat; Region: TPR_12; pfam13424 272561002340 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 272561002341 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272561002342 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 272561002343 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 272561002344 HemN C-terminal domain; Region: HemN_C; pfam06969 272561002345 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 272561002346 substrate binding site [chemical binding]; other site 272561002347 active site 272561002348 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 272561002349 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 272561002350 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 272561002351 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272561002352 ATP binding site [chemical binding]; other site 272561002353 putative Mg++ binding site [ion binding]; other site 272561002354 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272561002355 nucleotide binding region [chemical binding]; other site 272561002356 ATP-binding site [chemical binding]; other site 272561002357 TRCF domain; Region: TRCF; pfam03461 272561002358 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272561002359 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 272561002360 motif 1; other site 272561002361 active site 272561002362 motif 2; other site 272561002363 motif 3; other site 272561002364 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 272561002365 DHHA1 domain; Region: DHHA1; pfam02272 272561002366 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272561002367 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272561002368 TPP-binding site [chemical binding]; other site 272561002369 dimer interface [polypeptide binding]; other site 272561002370 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272561002371 PYR/PP interface [polypeptide binding]; other site 272561002372 dimer interface [polypeptide binding]; other site 272561002373 TPP binding site [chemical binding]; other site 272561002374 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272561002375 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 272561002376 translation elongation factor P; Region: efp; TIGR00038 272561002377 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272561002378 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272561002379 RNA binding site [nucleotide binding]; other site 272561002380 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272561002381 RNA binding site [nucleotide binding]; other site 272561002382 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272561002383 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272561002384 active site 272561002385 metal binding site [ion binding]; metal-binding site 272561002386 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272561002387 active site 272561002388 metal binding site [ion binding]; metal-binding site 272561002389 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 272561002390 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272561002391 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 272561002392 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272561002393 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272561002394 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 272561002395 Mg++ binding site [ion binding]; other site 272561002396 putative catalytic motif [active] 272561002397 putative substrate binding site [chemical binding]; other site 272561002398 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 272561002399 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272561002400 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272561002401 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272561002402 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272561002403 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272561002404 cell division protein FtsW; Region: ftsW; TIGR02614 272561002405 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 272561002406 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 272561002407 active site 272561002408 homodimer interface [polypeptide binding]; other site 272561002409 bifunctional D-alanyl-alanine synthetase A/UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: PRK14573 272561002410 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272561002411 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272561002412 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272561002413 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 272561002414 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 272561002415 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409 272561002416 G-X-X-G motif; other site 272561002417 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272561002418 anti sigma factor interaction site; other site 272561002419 regulatory phosphorylation site [posttranslational modification]; other site 272561002420 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 272561002421 hypothetical protein; Provisional; Region: PRK05927 272561002422 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 272561002423 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272561002424 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 272561002425 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 272561002426 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272561002427 dimer interface [polypeptide binding]; other site 272561002428 active site 272561002429 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 272561002430 nudix motif; other site 272561002431 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 272561002432 dimer interface [polypeptide binding]; other site 272561002433 substrate binding site [chemical binding]; other site 272561002434 metal binding sites [ion binding]; metal-binding site 272561002435 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 272561002436 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 272561002437 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 272561002438 NAD binding site [chemical binding]; other site 272561002439 Phe binding site; other site 272561002440 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 272561002441 active site 272561002442 putative lithium-binding site [ion binding]; other site 272561002443 substrate binding site [chemical binding]; other site 272561002444 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272561002445 putative acyl-acceptor binding pocket; other site 272561002446 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 272561002447 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272561002448 acyl-activating enzyme (AAE) consensus motif; other site 272561002449 AMP binding site [chemical binding]; other site 272561002450 active site 272561002451 CoA binding site [chemical binding]; other site 272561002452 8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937 272561002453 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 272561002454 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272561002455 catalytic residue [active] 272561002456 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 272561002457 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 272561002458 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272561002459 ATP binding site [chemical binding]; other site 272561002460 putative Mg++ binding site [ion binding]; other site 272561002461 helicase superfamily c-terminal domain; Region: HELICc; smart00490 272561002462 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 272561002463 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 272561002464 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272561002465 dimer interface [polypeptide binding]; other site 272561002466 putative anticodon binding site; other site 272561002467 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272561002468 motif 1; other site 272561002469 dimer interface [polypeptide binding]; other site 272561002470 active site 272561002471 motif 2; other site 272561002472 motif 3; other site 272561002473 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 272561002474 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272561002475 active site 272561002476 HIGH motif; other site 272561002477 KMSKS motif; other site 272561002478 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272561002479 tRNA binding surface [nucleotide binding]; other site 272561002480 anticodon binding site; other site 272561002481 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 272561002482 ribonuclease P; Reviewed; Region: rnpA; PRK00730 272561002483 Ribosomal protein L34 [Translation, ribosomal structure and biogenesis]; Region: RpmH; COG0230 272561002484 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 272561002485 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 272561002486 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 272561002487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 272561002488 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272561002489 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272561002490 GIY-YIG motif/motif A; other site 272561002491 active site 272561002492 catalytic site [active] 272561002493 putative DNA binding site [nucleotide binding]; other site 272561002494 metal binding site [ion binding]; metal-binding site 272561002495 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272561002496 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272561002497 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 272561002498 MutS domain I; Region: MutS_I; pfam01624 272561002499 MutS domain II; Region: MutS_II; pfam05188 272561002500 MutS domain III; Region: MutS_III; pfam05192 272561002501 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 272561002502 Walker A/P-loop; other site 272561002503 ATP binding site [chemical binding]; other site 272561002504 Q-loop/lid; other site 272561002505 ABC transporter signature motif; other site 272561002506 Walker B; other site 272561002507 D-loop; other site 272561002508 H-loop/switch region; other site 272561002509 DNA primase; Validated; Region: dnaG; PRK05667 272561002510 CHC2 zinc finger; Region: zf-CHC2; pfam01807 272561002511 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272561002512 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272561002513 active site 272561002514 metal binding site [ion binding]; metal-binding site 272561002515 interdomain interaction site; other site 272561002516 glycyl-tRNA synthetase; Provisional; Region: PRK14908 272561002517 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 272561002518 dimer interface [polypeptide binding]; other site 272561002519 motif 1; other site 272561002520 active site 272561002521 motif 2; other site 272561002522 motif 3; other site 272561002523 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 272561002524 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272561002525 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 272561002526 glycogen synthase; Provisional; Region: glgA; PRK00654 272561002527 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 272561002528 ADP-binding pocket [chemical binding]; other site 272561002529 homodimer interface [polypeptide binding]; other site 272561002530 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 272561002531 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 272561002532 5S rRNA interface [nucleotide binding]; other site 272561002533 CTC domain interface [polypeptide binding]; other site 272561002534 L16 interface [polypeptide binding]; other site 272561002535 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 272561002536 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272561002537 putative active site [active] 272561002538 catalytic residue [active] 272561002539 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 272561002540 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 272561002541 Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359 272561002542 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272561002543 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 272561002544 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK00650 272561002545 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272561002546 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 272561002547 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 272561002548 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272561002549 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272561002550 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272561002551 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 272561002552 putative acyl-acceptor binding pocket; other site 272561002553 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 272561002554 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 272561002555 homodimer interface [polypeptide binding]; other site 272561002556 oligonucleotide binding site [chemical binding]; other site 272561002557 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 272561002558 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 272561002559 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 272561002560 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 272561002561 Autotransporter beta-domain; Region: Autotransporter; pfam03797 272561002562 IncA protein; Region: IncA; pfam04156 272561002563 Protein of unknown function (DUF972); Region: DUF972; pfam06156 272561002564 YtxH-like protein; Region: YtxH; pfam12732 272561002565 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 272561002566 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 272561002567 active site 272561002568 substrate binding site [chemical binding]; other site 272561002569 metal binding site [ion binding]; metal-binding site 272561002570 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 272561002571 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 272561002572 glutaminase active site [active] 272561002573 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272561002574 dimer interface [polypeptide binding]; other site 272561002575 active site 272561002576 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272561002577 dimer interface [polypeptide binding]; other site 272561002578 active site 272561002579 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 272561002580 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 272561002581 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 272561002582 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 272561002583 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 272561002584 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 272561002585 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 272561002586 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 272561002587 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 272561002588 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 272561002589 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 272561002590 CoA-ligase; Region: Ligase_CoA; pfam00549 272561002591 succinyl-CoA synthetase, alpha subunit; Region: sucCoAalpha; TIGR01019 272561002592 CoA binding domain; Region: CoA_binding; pfam02629 272561002593 CoA-ligase; Region: Ligase_CoA; pfam00549 272561002594 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 272561002595 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272561002596 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272561002597 protein binding site [polypeptide binding]; other site 272561002598 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272561002599 protein binding site [polypeptide binding]; other site 272561002600 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 272561002601 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272561002602 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272561002603 Peptidase M16C associated; Region: M16C_assoc; pfam08367 272561002604 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272561002605 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 272561002606 RmuC family; Region: RmuC; pfam02646 272561002607 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 272561002608 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272561002609 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 272561002610 ATP cone domain; Region: ATP-cone; pfam03477 272561002611 ATP cone domain; Region: ATP-cone; pfam03477 272561002612 Class I ribonucleotide reductase; Region: RNR_I; cd01679 272561002613 active site 272561002614 dimer interface [polypeptide binding]; other site 272561002615 catalytic residues [active] 272561002616 effector binding site; other site 272561002617 R2 peptide binding site; other site 272561002618 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 272561002619 dimer interface [polypeptide binding]; other site 272561002620 putative radical transfer pathway; other site 272561002621 diiron center [ion binding]; other site 272561002622 tyrosyl radical; other site 272561002623 Putative methyltransferase; Region: Methyltransf_4; pfam02390 272561002624 Methyltransferase domain; Region: Methyltransf_18; pfam12847 272561002625 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 272561002626 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 272561002627 FAD binding domain; Region: FAD_binding_4; cl19922 272561002628 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 272561002629 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 272561002630 putative RNA binding site [nucleotide binding]; other site 272561002631 Translation initiation factor 3 (IF-3) [Translation, ribosomal structure and biogenesis]; Region: InfC; COG0290 272561002632 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272561002633 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272561002634 Ribosomal protein L35 [Translation, ribosomal structure and biogenesis]; Region: RpmI; COG0291 272561002635 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272561002636 23S rRNA binding site [nucleotide binding]; other site 272561002637 L21 binding site [polypeptide binding]; other site 272561002638 L13 binding site [polypeptide binding]; other site 272561002639 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272561002640 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272561002641 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272561002642 dimer interface [polypeptide binding]; other site 272561002643 motif 1; other site 272561002644 active site 272561002645 motif 2; other site 272561002646 motif 3; other site 272561002647 Predicted permeases [General function prediction only]; Region: COG0795 272561002648 Predicted permeases [General function prediction only]; Region: COG0795 272561002649 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272561002650 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272561002651 Ligand Binding Site [chemical binding]; other site 272561002652 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 272561002653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272561002654 Walker A motif; other site 272561002655 ATP binding site [chemical binding]; other site 272561002656 Walker B motif; other site 272561002657 arginine finger; other site 272561002658 Peptidase family M41; Region: Peptidase_M41; pfam01434 272561002659 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 272561002660 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 272561002661 RNase E interface [polypeptide binding]; other site 272561002662 trimer interface [polypeptide binding]; other site 272561002663 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 272561002664 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 272561002665 RNase E interface [polypeptide binding]; other site 272561002666 trimer interface [polypeptide binding]; other site 272561002667 active site 272561002668 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 272561002669 putative nucleic acid binding region [nucleotide binding]; other site 272561002670 G-X-X-G motif; other site 272561002671 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 272561002672 RNA binding site [nucleotide binding]; other site 272561002673 domain interface; other site 272561002674 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272561002675 16S/18S rRNA binding site [nucleotide binding]; other site 272561002676 S13e-L30e interaction site [polypeptide binding]; other site 272561002677 25S rRNA binding site [nucleotide binding]; other site 272561002678 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272561002679 nucleoside/Zn binding site; other site 272561002680 dimer interface [polypeptide binding]; other site 272561002681 catalytic motif [active] 272561002682 Protein of unknown function (DUF720); Region: DUF720; pfam05302 272561002683 Protein of unknown function (DUF720); Region: DUF720; pfam05302 272561002684 Protein of unknown function (DUF720); Region: DUF720; pfam05302 272561002685 Domain of unknown function (DUF334); Region: DUF334; pfam03904 272561002686 Geminin; Region: Geminin; pfam07412 272561002687 methionine aminopeptidase; Provisional; Region: PRK12318 272561002688 SEC-C motif; Region: SEC-C; pfam02810 272561002689 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272561002690 active site 272561002691 MarC family integral membrane protein; Region: MarC; pfam01914 272561002692 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 272561002693 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272561002694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272561002695 dimer interface [polypeptide binding]; other site 272561002696 conserved gate region; other site 272561002697 putative PBP binding loops; other site 272561002698 ABC-ATPase subunit interface; other site 272561002699 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272561002700 NMT1/THI5 like; Region: NMT1; pfam09084 272561002701 fumarate hydratase, class II; Region: fumC_II; TIGR00979 272561002702 Class II fumarases; Region: Fumarase_classII; cd01362 272561002703 active site 272561002704 tetramer interface [polypeptide binding]; other site 272561002705 high affinity sulphate transporter 1; Region: sulP; TIGR00815 272561002706 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272561002707 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272561002708 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272561002709 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 272561002710 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 272561002711 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 272561002712 active site triad [active] 272561002713 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 272561002714 Fe-S cluster binding site [ion binding]; other site 272561002715 substrate binding site [chemical binding]; other site 272561002716 catalytic site [active] 272561002717 ATP synthase I chain; Region: ATP_synt_I; pfam03899 272561002718 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 272561002719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272561002720 binding surface 272561002721 TPR motif; other site 272561002722 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 272561002723 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272561002724 active site 272561002725 DNA binding site [nucleotide binding] 272561002726 Int/Topo IB signature motif; other site 272561002727 glycogen branching enzyme; Provisional; Region: PRK05402 272561002728 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 272561002729 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 272561002730 active site 272561002731 catalytic site [active] 272561002732 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 272561002733 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 272561002734 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 272561002735 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 272561002736 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 272561002737 Autotransporter beta-domain; Region: Autotransporter; pfam03797 272561002738 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 272561002739 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 272561002740 Autotransporter beta-domain; Region: Autotransporter; pfam03797 272561002741 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 272561002742 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 272561002743 Autotransporter beta-domain; Region: Autotransporter; pfam03797 272561002744 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 272561002745 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 272561002746 Autotransporter beta-domain; Region: Autotransporter; pfam03797 272561002747 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 272561002748 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 272561002749 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 272561002750 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 272561002751 Autotransporter beta-domain; Region: Autotransporter; pfam03797