-- dump date 20140619_030905 -- class Genbank::misc_feature -- table misc_feature_note -- id note 266779000001 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 266779000002 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 266779000003 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 266779000004 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 266779000005 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266779000006 Domain of unknown function DUF; Region: DUF204; pfam02659 266779000007 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 266779000008 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 266779000009 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 266779000010 catalytic residues [active] 266779000011 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 266779000012 pseudoazurin; Region: pseudoazurin; TIGR02375 266779000013 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 266779000014 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 266779000015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266779000016 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266779000017 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 266779000018 Thioredoxin; Region: Thioredoxin_4; pfam13462 266779000019 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 266779000020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266779000021 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266779000022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 266779000023 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 266779000024 Protein of unknown function (DUF461); Region: DUF461; pfam04314 266779000025 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 266779000026 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 266779000027 DNA binding residues [nucleotide binding] 266779000028 dimer interface [polypeptide binding]; other site 266779000029 putative metal binding site [ion binding]; other site 266779000030 manganese transport protein MntH; Reviewed; Region: PRK00701 266779000031 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 266779000032 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266779000033 putative catalytic site [active] 266779000034 putative metal binding site [ion binding]; other site 266779000035 putative phosphate binding site [ion binding]; other site 266779000036 osmolarity response regulator; Provisional; Region: ompR; PRK09468 266779000037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779000038 active site 266779000039 phosphorylation site [posttranslational modification] 266779000040 intermolecular recognition site; other site 266779000041 dimerization interface [polypeptide binding]; other site 266779000042 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266779000043 DNA binding site [nucleotide binding] 266779000044 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 266779000045 HAMP domain; Region: HAMP; pfam00672 266779000046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779000047 dimer interface [polypeptide binding]; other site 266779000048 phosphorylation site [posttranslational modification] 266779000049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779000050 ATP binding site [chemical binding]; other site 266779000051 Mg2+ binding site [ion binding]; other site 266779000052 G-X-G motif; other site 266779000053 Cation efflux family; Region: Cation_efflux; cl00316 266779000054 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 266779000055 HflK protein; Region: hflK; TIGR01933 266779000056 HflC protein; Region: hflC; TIGR01932 266779000057 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 266779000058 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 266779000059 HflK protein; Region: hflK; TIGR01933 266779000060 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 266779000061 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 266779000062 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266779000063 metal-binding site [ion binding] 266779000064 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 266779000065 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266779000066 metal-binding site [ion binding] 266779000067 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266779000068 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 266779000069 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 266779000070 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 266779000071 Cu(I) binding site [ion binding]; other site 266779000072 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 266779000073 Thioredoxin; Region: Thioredoxin_4; pfam13462 266779000074 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 266779000075 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 266779000076 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 266779000077 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266779000078 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266779000079 active site 266779000080 catalytic residues [active] 266779000081 DNA binding site [nucleotide binding] 266779000082 Int/Topo IB signature motif; other site 266779000083 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 266779000084 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266779000085 ParB-like nuclease domain; Region: ParB; smart00470 266779000086 Protein of unknown function (DUF1419); Region: DUF1419; pfam07215 266779000087 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 266779000088 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 266779000089 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 266779000090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779000091 S-adenosylmethionine binding site [chemical binding]; other site 266779000092 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 266779000093 Helicase_C-like; Region: Helicase_C_4; pfam13871 266779000094 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 266779000095 active site 266779000096 metal binding site [ion binding]; metal-binding site 266779000097 interdomain interaction site; other site 266779000098 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 266779000099 Protein of unknown function (DUF736); Region: DUF736; pfam05284 266779000100 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 266779000101 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266779000102 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266779000103 Magnesium ion binding site [ion binding]; other site 266779000104 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 266779000105 RES domain; Region: RES; pfam08808 266779000106 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 266779000107 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266779000108 Walker A motif; other site 266779000109 ATP binding site [chemical binding]; other site 266779000110 Walker B motif; other site 266779000111 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 266779000112 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266779000113 Walker A motif; other site 266779000114 hexamer interface [polypeptide binding]; other site 266779000115 ATP binding site [chemical binding]; other site 266779000116 Walker B motif; other site 266779000117 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 266779000118 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266779000119 VirB7 interaction site; other site 266779000120 VirB8 protein; Region: VirB8; pfam04335 266779000121 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 266779000122 Type IV secretion system proteins; Region: T4SS; pfam07996 266779000123 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266779000124 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266779000125 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266779000126 catalytic residue [active] 266779000127 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 266779000128 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266779000129 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 266779000130 TrbC/VIRB2 family; Region: TrbC; pfam04956 266779000131 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266779000132 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266779000133 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266779000134 catalytic residue [active] 266779000135 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 266779000136 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 266779000137 Staphylococcal nuclease homologues; Region: SNc; smart00318 266779000138 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 266779000139 Catalytic site; other site 266779000140 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266779000141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779000142 active site 266779000143 phosphorylation site [posttranslational modification] 266779000144 intermolecular recognition site; other site 266779000145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779000146 S-adenosylmethionine binding site [chemical binding]; other site 266779000147 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 266779000148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266779000149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779000150 ATP binding site [chemical binding]; other site 266779000151 G-X-G motif; other site 266779000152 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 266779000153 MerR family regulatory protein; Region: MerR; pfam00376 266779000154 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266779000155 P-loop; other site 266779000156 Magnesium ion binding site [ion binding]; other site 266779000157 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266779000158 Magnesium ion binding site [ion binding]; other site 266779000159 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 266779000160 ParB-like nuclease domain; Region: ParBc; pfam02195 266779000161 replication initiation protein RepC; Provisional; Region: PRK13824 266779000162 Helix-turn-helix domain; Region: HTH_36; pfam13730 266779000163 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779000164 putative DNA binding site [nucleotide binding]; other site 266779000165 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 266779000166 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 266779000167 DNA binding site [nucleotide binding] 266779000168 dimer interface [polypeptide binding]; other site 266779000169 active site 266779000170 Int/Topo IB signature motif; other site 266779000171 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 266779000172 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 266779000173 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779000174 putative DNA binding site [nucleotide binding]; other site 266779000175 putative Zn2+ binding site [ion binding]; other site 266779000176 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266779000177 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 266779000178 active site 266779000179 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 266779000180 amphipathic channel; other site 266779000181 Asn-Pro-Ala signature motifs; other site 266779000182 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 266779000183 ArsC family; Region: ArsC; pfam03960 266779000184 catalytic residues [active] 266779000185 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779000186 dimerization interface [polypeptide binding]; other site 266779000187 putative DNA binding site [nucleotide binding]; other site 266779000188 putative Zn2+ binding site [ion binding]; other site 266779000189 NAD synthetase; Reviewed; Region: nadE; PRK02628 266779000190 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 266779000191 multimer interface [polypeptide binding]; other site 266779000192 active site 266779000193 catalytic triad [active] 266779000194 protein interface 1 [polypeptide binding]; other site 266779000195 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 266779000196 homodimer interface [polypeptide binding]; other site 266779000197 NAD binding pocket [chemical binding]; other site 266779000198 ATP binding pocket [chemical binding]; other site 266779000199 Mg binding site [ion binding]; other site 266779000200 active-site loop [active] 266779000201 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 266779000202 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 266779000203 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 266779000204 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266779000205 Heavy-metal-associated domain; Region: HMA; pfam00403 266779000206 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266779000207 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266779000208 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266779000209 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 266779000210 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 266779000211 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 266779000212 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 266779000213 DNA binding residues [nucleotide binding] 266779000214 dimer interface [polypeptide binding]; other site 266779000215 putative metal binding site [ion binding]; other site 266779000216 YtkA-like; Region: YtkA; pfam13115 266779000217 Bacterial TniB protein; Region: TniB; pfam05621 266779000218 AAA domain; Region: AAA_22; pfam13401 266779000219 Helix-turn-helix domain; Region: HTH_28; pfam13518 266779000220 Winged helix-turn helix; Region: HTH_29; pfam13551 266779000221 Integrase core domain; Region: rve; pfam00665 266779000222 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 266779000223 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 266779000224 Helicase_C-like; Region: Helicase_C_4; pfam13871 266779000225 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 266779000226 active site 266779000227 metal binding site [ion binding]; metal-binding site 266779000228 interdomain interaction site; other site 266779000229 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 266779000230 PemK-like protein; Region: PemK; pfam02452 266779000231 Protein of unknown function (DUF736); Region: DUF736; pfam05284 266779000232 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 266779000233 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266779000234 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266779000235 DNA binding site [nucleotide binding] 266779000236 active site 266779000237 Int/Topo IB signature motif; other site 266779000238 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 266779000239 WGR domain; Region: WGR; cl01581 266779000240 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266779000241 IHF dimer interface [polypeptide binding]; other site 266779000242 IHF - DNA interface [nucleotide binding]; other site 266779000243 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 266779000244 putative active site [active] 266779000245 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266779000246 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266779000247 non-specific DNA binding site [nucleotide binding]; other site 266779000248 salt bridge; other site 266779000249 sequence-specific DNA binding site [nucleotide binding]; other site 266779000250 stage V sporulation protein K; Region: spore_V_K; TIGR02881 266779000251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779000252 Walker A motif; other site 266779000253 ATP binding site [chemical binding]; other site 266779000254 Walker B motif; other site 266779000255 arginine finger; other site 266779000256 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 266779000257 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266779000258 Walker A motif; other site 266779000259 ATP binding site [chemical binding]; other site 266779000260 Walker B motif; other site 266779000261 Conjugal transfer protein TraD; Region: TraD; pfam06412 266779000262 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 266779000263 MobA/MobL family; Region: MobA_MobL; pfam03389 266779000264 AAA domain; Region: AAA_30; pfam13604 266779000265 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 266779000266 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266779000267 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266779000268 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 266779000269 NAD binding site [chemical binding]; other site 266779000270 aminotransferase; Provisional; Region: PRK06105 266779000271 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266779000272 inhibitor-cofactor binding pocket; inhibition site 266779000273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779000274 catalytic residue [active] 266779000275 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 266779000276 homodimer interface [polypeptide binding]; other site 266779000277 homotetramer interface [polypeptide binding]; other site 266779000278 active site pocket [active] 266779000279 cleavage site 266779000280 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266779000281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779000282 Walker A/P-loop; other site 266779000283 ATP binding site [chemical binding]; other site 266779000284 Q-loop/lid; other site 266779000285 ABC transporter signature motif; other site 266779000286 Walker B; other site 266779000287 D-loop; other site 266779000288 H-loop/switch region; other site 266779000289 TOBE domain; Region: TOBE_2; pfam08402 266779000290 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266779000291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779000292 dimer interface [polypeptide binding]; other site 266779000293 conserved gate region; other site 266779000294 putative PBP binding loops; other site 266779000295 ABC-ATPase subunit interface; other site 266779000296 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266779000297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779000298 dimer interface [polypeptide binding]; other site 266779000299 conserved gate region; other site 266779000300 putative PBP binding loops; other site 266779000301 ABC-ATPase subunit interface; other site 266779000302 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266779000303 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266779000304 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 266779000305 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779000306 DNA-binding site [nucleotide binding]; DNA binding site 266779000307 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266779000308 FCD domain; Region: FCD; pfam07729 266779000309 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266779000310 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266779000311 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 266779000312 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 266779000313 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 266779000314 glycine dehydrogenase; Provisional; Region: PRK05367 266779000315 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 266779000316 tetramer interface [polypeptide binding]; other site 266779000317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779000318 catalytic residue [active] 266779000319 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 266779000320 tetramer interface [polypeptide binding]; other site 266779000321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779000322 catalytic residue [active] 266779000323 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 266779000324 lipoyl attachment site [posttranslational modification]; other site 266779000325 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 266779000326 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266779000327 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 266779000328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266779000329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266779000330 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266779000331 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 266779000332 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 266779000333 dimer interface [polypeptide binding]; other site 266779000334 active site 266779000335 glycine-pyridoxal phosphate binding site [chemical binding]; other site 266779000336 folate binding site [chemical binding]; other site 266779000337 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779000338 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266779000339 dimerization interface [polypeptide binding]; other site 266779000340 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 266779000341 Uncharacterized conserved protein [Function unknown]; Region: COG1262 266779000342 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 266779000343 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 266779000344 Multicopper oxidase; Region: Cu-oxidase; pfam00394 266779000345 NnrS protein; Region: NnrS; pfam05940 266779000346 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 266779000347 pseudoazurin; Region: pseudoazurin; TIGR02375 266779000348 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266779000349 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266779000350 ligand binding site [chemical binding]; other site 266779000351 flexible hinge region; other site 266779000352 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266779000353 putative switch regulator; other site 266779000354 non-specific DNA interactions [nucleotide binding]; other site 266779000355 DNA binding site [nucleotide binding] 266779000356 sequence specific DNA binding site [nucleotide binding]; other site 266779000357 putative cAMP binding site [chemical binding]; other site 266779000358 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 266779000359 Rrf2 family protein; Region: rrf2_super; TIGR00738 266779000360 Transcriptional regulator; Region: Rrf2; cl17282 266779000361 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 266779000362 apolar tunnel; other site 266779000363 heme binding site [chemical binding]; other site 266779000364 dimerization interface [polypeptide binding]; other site 266779000365 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 266779000366 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 266779000367 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 266779000368 CPxP motif; other site 266779000369 Fe2+ transport protein; Region: Iron_transport; pfam10634 266779000370 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 266779000371 Iron permease FTR1 family; Region: FTR1; cl00475 266779000372 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 266779000373 4Fe-4S binding domain; Region: Fer4_5; pfam12801 266779000374 NnrS protein; Region: NnrS; pfam05940 266779000375 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 266779000376 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 266779000377 Flavoprotein; Region: Flavoprotein; pfam02441 266779000378 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 266779000379 SCP-2 sterol transfer family; Region: SCP2; cl01225 266779000380 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 266779000381 Peptidase family U32; Region: Peptidase_U32; pfam01136 266779000382 putative protease; Provisional; Region: PRK15447 266779000383 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 266779000384 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 266779000385 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266779000386 FeS/SAM binding site; other site 266779000387 HemN C-terminal domain; Region: HemN_C; pfam06969 266779000388 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 266779000389 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 266779000390 active site 266779000391 metal binding site [ion binding]; metal-binding site 266779000392 nudix motif; other site 266779000393 Hemerythrin; Region: Hemerythrin; cd12107 266779000394 Fe binding site [ion binding]; other site 266779000395 heme bH binding site [chemical binding]; other site 266779000396 Qi binding site; other site 266779000397 intrachain domain interface; other site 266779000398 heme bL binding site [chemical binding]; other site 266779000399 interchain domain interface [polypeptide binding]; other site 266779000400 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 266779000401 Qo binding site; other site 266779000402 4Fe-4S binding domain; Region: Fer4_6; pfam12837 266779000403 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 266779000404 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 266779000405 Bacterial TniB protein; Region: TniB; pfam05621 266779000406 AAA domain; Region: AAA_22; pfam13401 266779000407 Helix-turn-helix domain; Region: HTH_28; pfam13518 266779000408 Winged helix-turn helix; Region: HTH_29; pfam13551 266779000409 Integrase core domain; Region: rve; pfam00665 266779000410 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 266779000411 RibD C-terminal domain; Region: RibD_C; cl17279 266779000412 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 266779000413 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 266779000414 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 266779000415 active site 266779000416 metal binding site [ion binding]; metal-binding site 266779000417 Protein of unknown function (DUF1419); Region: DUF1419; pfam07215 266779000418 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 266779000419 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 266779000420 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266779000421 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266779000422 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266779000423 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 266779000424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779000425 S-adenosylmethionine binding site [chemical binding]; other site 266779000426 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 266779000427 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266779000428 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 266779000429 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 266779000430 helicase superfamily c-terminal domain; Region: HELICc; smart00490 266779000431 plasmid partitioning protein; Provisional; Region: PRK13832 266779000432 ParB-like nuclease domain; Region: ParB; smart00470 266779000433 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 266779000434 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 266779000435 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 266779000436 Ligand Binding Site [chemical binding]; other site 266779000437 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 266779000438 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 266779000439 putative active site [active] 266779000440 Uncharacterized conserved protein [Function unknown]; Region: COG5489 266779000441 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 266779000442 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 266779000443 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 266779000444 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cl00559 266779000445 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266779000446 Walker A motif; other site 266779000447 ATP binding site [chemical binding]; other site 266779000448 Walker B motif; other site 266779000449 Conjugal transfer protein TraD; Region: TraD; pfam06412 266779000450 TraC-like protein; Region: TraC; cl06725 266779000451 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 266779000452 MobA/MobL family; Region: MobA_MobL; pfam03389 266779000453 AAA domain; Region: AAA_30; pfam13604 266779000454 Family description; Region: UvrD_C_2; pfam13538 266779000455 Zeta toxin; Region: Zeta_toxin; pfam06414 266779000456 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 266779000457 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266779000458 Walker A motif; other site 266779000459 hexamer interface [polypeptide binding]; other site 266779000460 ATP binding site [chemical binding]; other site 266779000461 Walker B motif; other site 266779000462 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 266779000463 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266779000464 VirB7 interaction site; other site 266779000465 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 266779000466 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 266779000467 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 266779000468 Type IV secretion system proteins; Region: T4SS; pfam07996 266779000469 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 266779000470 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266779000471 Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702 266779000472 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 266779000473 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 266779000474 Replication protein C N-terminal domain; Region: RP-C; pfam03428 266779000475 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 266779000476 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 266779000477 hypothetical protein; Provisional; Region: PRK06518 266779000478 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 266779000479 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266779000480 P-loop; other site 266779000481 Magnesium ion binding site [ion binding]; other site 266779000482 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266779000483 Magnesium ion binding site [ion binding]; other site 266779000484 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 266779000485 ParB-like nuclease domain; Region: ParBc; pfam02195 266779000486 replication initiation protein RepC; Provisional; Region: PRK13824 266779000487 Replication protein C N-terminal domain; Region: RP-C; pfam03428 266779000488 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 266779000489 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266779000490 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266779000491 catalytic residues [active] 266779000492 catalytic nucleophile [active] 266779000493 Presynaptic Site I dimer interface [polypeptide binding]; other site 266779000494 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266779000495 Synaptic Flat tetramer interface [polypeptide binding]; other site 266779000496 Synaptic Site I dimer interface [polypeptide binding]; other site 266779000497 DNA binding site [nucleotide binding] 266779000498 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 266779000499 DNA binding site [nucleotide binding] 266779000500 dimer interface [polypeptide binding]; other site 266779000501 active site 266779000502 Int/Topo IB signature motif; other site 266779000503 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 266779000504 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266779000505 Integrase core domain; Region: rve; pfam00665 266779000506 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 266779000507 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779000508 DNA-binding site [nucleotide binding]; DNA binding site 266779000509 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266779000510 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 266779000511 homotrimer interaction site [polypeptide binding]; other site 266779000512 putative active site [active] 266779000513 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266779000514 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266779000515 homotrimer interaction site [polypeptide binding]; other site 266779000516 putative active site [active] 266779000517 serine racemase; Region: PLN02970 266779000518 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266779000519 tetramer interface [polypeptide binding]; other site 266779000520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779000521 catalytic residue [active] 266779000522 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 266779000523 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 266779000524 dimer interface [polypeptide binding]; other site 266779000525 active site 266779000526 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266779000527 substrate binding site [chemical binding]; other site 266779000528 catalytic residue [active] 266779000529 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 266779000530 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266779000531 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 266779000532 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779000533 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266779000534 dimerization interface [polypeptide binding]; other site 266779000535 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 266779000536 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266779000537 substrate binding pocket [chemical binding]; other site 266779000538 membrane-bound complex binding site; other site 266779000539 hinge residues; other site 266779000540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779000541 dimer interface [polypeptide binding]; other site 266779000542 conserved gate region; other site 266779000543 putative PBP binding loops; other site 266779000544 ABC-ATPase subunit interface; other site 266779000545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779000546 dimer interface [polypeptide binding]; other site 266779000547 conserved gate region; other site 266779000548 putative PBP binding loops; other site 266779000549 ABC-ATPase subunit interface; other site 266779000550 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266779000551 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266779000552 Walker A/P-loop; other site 266779000553 ATP binding site [chemical binding]; other site 266779000554 Q-loop/lid; other site 266779000555 ABC transporter signature motif; other site 266779000556 Walker B; other site 266779000557 D-loop; other site 266779000558 H-loop/switch region; other site 266779000559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779000560 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266779000561 dimerization interface [polypeptide binding]; other site 266779000562 substrate binding pocket [chemical binding]; other site 266779000563 Integrase core domain; Region: rve; pfam00665 266779000564 DDE domain; Region: DDE_Tnp_IS240; pfam13610 266779000565 Integrase core domain; Region: rve_3; pfam13683 266779000566 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266779000567 Transposase; Region: HTH_Tnp_1; cl17663 266779000568 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 266779000569 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 266779000570 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266779000571 multiple promoter invertase; Provisional; Region: mpi; PRK13413 266779000572 catalytic residues [active] 266779000573 catalytic nucleophile [active] 266779000574 Presynaptic Site I dimer interface [polypeptide binding]; other site 266779000575 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266779000576 Synaptic Flat tetramer interface [polypeptide binding]; other site 266779000577 Synaptic Site I dimer interface [polypeptide binding]; other site 266779000578 DNA binding site [nucleotide binding] 266779000579 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266779000580 DNA-binding interface [nucleotide binding]; DNA binding site 266779000581 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266779000582 Bacterial TniB protein; Region: TniB; pfam05621 266779000583 AAA domain; Region: AAA_22; pfam13401 266779000584 Helix-turn-helix domain; Region: HTH_28; pfam13518 266779000585 Winged helix-turn helix; Region: HTH_29; pfam13551 266779000586 Integrase core domain; Region: rve; pfam00665 266779000587 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 266779000588 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 266779000589 HlyD family secretion protein; Region: HlyD_3; pfam13437 266779000590 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 266779000591 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 266779000592 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 266779000593 Multicopper oxidase; Region: Cu-oxidase; pfam00394 266779000594 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 266779000595 Protein of unknown function, DUF; Region: DUF411; cl01142 266779000596 TniQ; Region: TniQ; pfam06527 266779000597 Bacterial TniB protein; Region: TniB; pfam05621 266779000598 AAA domain; Region: AAA_22; pfam13401 266779000599 Integrase core domain; Region: rve; pfam00665 266779000600 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 266779000601 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 266779000602 HTH DNA binding domain; Region: HTH_13; pfam11972 266779000603 RES domain; Region: RES; pfam08808 266779000604 Helix-turn-helix domain; Region: HTH_19; pfam12844 266779000605 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 266779000606 active site 266779000607 NTP binding site [chemical binding]; other site 266779000608 metal binding triad [ion binding]; metal-binding site 266779000609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779000610 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266779000611 Walker A motif; other site 266779000612 ATP binding site [chemical binding]; other site 266779000613 Walker B motif; other site 266779000614 arginine finger; other site 266779000615 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 266779000616 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266779000617 ATP binding site [chemical binding]; other site 266779000618 putative Mg++ binding site [ion binding]; other site 266779000619 nucleotide binding region [chemical binding]; other site 266779000620 helicase superfamily c-terminal domain; Region: HELICc; smart00490 266779000621 ATP-binding site [chemical binding]; other site 266779000622 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 266779000623 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 266779000624 Competence protein CoiA-like family; Region: CoiA; cl11541 266779000625 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 266779000626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266779000627 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266779000628 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 266779000629 HTH DNA binding domain; Region: HTH_13; pfam11972 266779000630 Cytochrome C' Region: Cytochrom_C_2; pfam01322 266779000631 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 266779000632 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 266779000633 manganese transport regulator MntR; Provisional; Region: PRK11050 266779000634 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 266779000635 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 266779000636 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266779000637 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 266779000638 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266779000639 DNA binding residues [nucleotide binding] 266779000640 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266779000641 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266779000642 Walker A/P-loop; other site 266779000643 ATP binding site [chemical binding]; other site 266779000644 Q-loop/lid; other site 266779000645 ABC transporter signature motif; other site 266779000646 Walker B; other site 266779000647 D-loop; other site 266779000648 H-loop/switch region; other site 266779000649 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266779000650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779000651 dimer interface [polypeptide binding]; other site 266779000652 conserved gate region; other site 266779000653 putative PBP binding loops; other site 266779000654 ABC-ATPase subunit interface; other site 266779000655 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 266779000656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779000657 conserved gate region; other site 266779000658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779000659 putative PBP binding loops; other site 266779000660 dimer interface [polypeptide binding]; other site 266779000661 ABC-ATPase subunit interface; other site 266779000662 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 266779000663 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266779000664 substrate binding pocket [chemical binding]; other site 266779000665 membrane-bound complex binding site; other site 266779000666 hinge residues; other site 266779000667 cystathionine beta-lyase; Provisional; Region: PRK07050 266779000668 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266779000669 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266779000670 catalytic residue [active] 266779000671 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779000672 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 266779000673 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 266779000674 putative dimerization interface [polypeptide binding]; other site 266779000675 Renin receptor-like protein; Region: Renin_r; pfam07850 266779000676 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266779000677 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266779000678 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266779000679 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266779000680 metal binding site 2 [ion binding]; metal-binding site 266779000681 putative DNA binding helix; other site 266779000682 metal binding site 1 [ion binding]; metal-binding site 266779000683 dimer interface [polypeptide binding]; other site 266779000684 structural Zn2+ binding site [ion binding]; other site 266779000685 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266779000686 Ligand Binding Site [chemical binding]; other site 266779000687 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 266779000688 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 266779000689 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 266779000690 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 266779000691 putative active site [active] 266779000692 catalytic triad [active] 266779000693 putative dimer interface [polypeptide binding]; other site 266779000694 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 266779000695 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 266779000696 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 266779000697 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266779000698 NAD binding site [chemical binding]; other site 266779000699 ligand binding site [chemical binding]; other site 266779000700 catalytic site [active] 266779000701 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266779000702 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 266779000703 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779000704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779000705 dimer interface [polypeptide binding]; other site 266779000706 conserved gate region; other site 266779000707 putative PBP binding loops; other site 266779000708 ABC-ATPase subunit interface; other site 266779000709 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266779000710 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266779000711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779000712 dimer interface [polypeptide binding]; other site 266779000713 conserved gate region; other site 266779000714 putative PBP binding loops; other site 266779000715 ABC-ATPase subunit interface; other site 266779000716 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266779000717 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779000718 Walker A/P-loop; other site 266779000719 ATP binding site [chemical binding]; other site 266779000720 Q-loop/lid; other site 266779000721 ABC transporter signature motif; other site 266779000722 Walker B; other site 266779000723 D-loop; other site 266779000724 H-loop/switch region; other site 266779000725 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266779000726 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266779000727 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779000728 Walker A/P-loop; other site 266779000729 ATP binding site [chemical binding]; other site 266779000730 Q-loop/lid; other site 266779000731 ABC transporter signature motif; other site 266779000732 Walker B; other site 266779000733 D-loop; other site 266779000734 H-loop/switch region; other site 266779000735 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266779000736 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 266779000737 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266779000738 NAD binding site [chemical binding]; other site 266779000739 ligand binding site [chemical binding]; other site 266779000740 catalytic site [active] 266779000741 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 266779000742 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 266779000743 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 266779000744 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 266779000745 succinic semialdehyde dehydrogenase; Region: PLN02278 266779000746 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266779000747 tetramerization interface [polypeptide binding]; other site 266779000748 NAD(P) binding site [chemical binding]; other site 266779000749 catalytic residues [active] 266779000750 6-hydroxyhexanoate dehydrogenase (HHD) catalyzes the oxidation of 6-hydroxyhexanoate to 6-oxohexanoate; Region: HHD; cd08191 266779000751 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 266779000752 putative active site [active] 266779000753 metal binding site [ion binding]; metal-binding site 266779000754 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 266779000755 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266779000756 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266779000757 active site pocket [active] 266779000758 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266779000759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779000760 Walker A/P-loop; other site 266779000761 ATP binding site [chemical binding]; other site 266779000762 Q-loop/lid; other site 266779000763 ABC transporter signature motif; other site 266779000764 Walker B; other site 266779000765 D-loop; other site 266779000766 H-loop/switch region; other site 266779000767 TOBE domain; Region: TOBE_2; pfam08402 266779000768 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266779000769 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266779000770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779000771 dimer interface [polypeptide binding]; other site 266779000772 conserved gate region; other site 266779000773 putative PBP binding loops; other site 266779000774 ABC-ATPase subunit interface; other site 266779000775 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266779000776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779000777 dimer interface [polypeptide binding]; other site 266779000778 conserved gate region; other site 266779000779 putative PBP binding loops; other site 266779000780 ABC-ATPase subunit interface; other site 266779000781 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 266779000782 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266779000783 putative active site pocket [active] 266779000784 metal binding site [ion binding]; metal-binding site 266779000785 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 266779000786 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266779000787 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266779000788 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266779000789 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779000790 DNA-binding site [nucleotide binding]; DNA binding site 266779000791 FCD domain; Region: FCD; pfam07729 266779000792 DDE domain; Region: DDE_Tnp_IS240; pfam13610 266779000793 hypothetical protein; Validated; Region: PRK08245 266779000794 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266779000795 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266779000796 inhibitor site; inhibition site 266779000797 active site 266779000798 dimer interface [polypeptide binding]; other site 266779000799 catalytic residue [active] 266779000800 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 266779000801 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266779000802 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 266779000803 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266779000804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779000805 DNA-binding site [nucleotide binding]; DNA binding site 266779000806 FCD domain; Region: FCD; pfam07729 266779000807 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 266779000808 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779000809 DNA-binding site [nucleotide binding]; DNA binding site 266779000810 FCD domain; Region: FCD; pfam07729 266779000811 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 266779000812 Putative transposase; Region: Y2_Tnp; pfam04986 266779000813 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 266779000814 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266779000815 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266779000816 acyl-activating enzyme (AAE) consensus motif; other site 266779000817 acyl-activating enzyme (AAE) consensus motif; other site 266779000818 putative AMP binding site [chemical binding]; other site 266779000819 putative active site [active] 266779000820 putative CoA binding site [chemical binding]; other site 266779000821 Amidohydrolase; Region: Amidohydro_2; pfam04909 266779000822 enoyl-CoA hydratase; Provisional; Region: PRK06688 266779000823 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266779000824 substrate binding site [chemical binding]; other site 266779000825 oxyanion hole (OAH) forming residues; other site 266779000826 trimer interface [polypeptide binding]; other site 266779000827 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 266779000828 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266779000829 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266779000830 active site 266779000831 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266779000832 MarR family; Region: MarR_2; pfam12802 266779000833 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 266779000834 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 266779000835 active site 266779000836 oxalacetate binding site [chemical binding]; other site 266779000837 citrylCoA binding site [chemical binding]; other site 266779000838 coenzyme A binding site [chemical binding]; other site 266779000839 catalytic triad [active] 266779000840 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266779000841 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266779000842 Walker A/P-loop; other site 266779000843 ATP binding site [chemical binding]; other site 266779000844 Q-loop/lid; other site 266779000845 ABC transporter signature motif; other site 266779000846 Walker B; other site 266779000847 D-loop; other site 266779000848 H-loop/switch region; other site 266779000849 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266779000850 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266779000851 Walker A/P-loop; other site 266779000852 ATP binding site [chemical binding]; other site 266779000853 Q-loop/lid; other site 266779000854 ABC transporter signature motif; other site 266779000855 Walker B; other site 266779000856 D-loop; other site 266779000857 H-loop/switch region; other site 266779000858 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266779000859 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266779000860 TM-ABC transporter signature motif; other site 266779000861 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266779000862 TM-ABC transporter signature motif; other site 266779000863 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266779000864 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 266779000865 ligand binding site [chemical binding]; other site 266779000866 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266779000867 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 266779000868 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266779000869 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266779000870 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266779000871 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266779000872 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266779000873 active site 266779000874 metal binding site [ion binding]; metal-binding site 266779000875 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779000876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779000877 dimer interface [polypeptide binding]; other site 266779000878 conserved gate region; other site 266779000879 putative PBP binding loops; other site 266779000880 ABC-ATPase subunit interface; other site 266779000881 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266779000882 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 266779000883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779000884 dimer interface [polypeptide binding]; other site 266779000885 conserved gate region; other site 266779000886 putative PBP binding loops; other site 266779000887 ABC-ATPase subunit interface; other site 266779000888 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266779000889 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779000890 Walker A/P-loop; other site 266779000891 ATP binding site [chemical binding]; other site 266779000892 Q-loop/lid; other site 266779000893 ABC transporter signature motif; other site 266779000894 Walker B; other site 266779000895 D-loop; other site 266779000896 H-loop/switch region; other site 266779000897 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779000898 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 266779000899 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779000900 Walker A/P-loop; other site 266779000901 ATP binding site [chemical binding]; other site 266779000902 Q-loop/lid; other site 266779000903 ABC transporter signature motif; other site 266779000904 Walker B; other site 266779000905 D-loop; other site 266779000906 H-loop/switch region; other site 266779000907 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266779000908 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266779000909 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266779000910 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266779000911 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266779000912 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266779000913 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266779000914 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266779000915 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266779000916 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 266779000917 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 266779000918 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266779000919 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266779000920 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266779000921 substrate binding site [chemical binding]; other site 266779000922 ATP binding site [chemical binding]; other site 266779000923 glucuronate isomerase; Reviewed; Region: PRK02925 266779000924 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 266779000925 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 266779000926 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 266779000927 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 266779000928 mannonate dehydratase; Provisional; Region: PRK03906 266779000929 mannonate dehydratase; Region: uxuA; TIGR00695 266779000930 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266779000931 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779000932 DNA-binding site [nucleotide binding]; DNA binding site 266779000933 FCD domain; Region: FCD; pfam07729 266779000934 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266779000935 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 266779000936 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 266779000937 putative active site [active] 266779000938 metal binding site [ion binding]; metal-binding site 266779000939 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 266779000940 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266779000941 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 266779000942 active site 266779000943 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 266779000944 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266779000945 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 266779000946 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 266779000947 DctM-like transporters; Region: DctM; pfam06808 266779000948 DDE domain; Region: DDE_Tnp_IS240; pfam13610 266779000949 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266779000950 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266779000951 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266779000952 Walker A/P-loop; other site 266779000953 ATP binding site [chemical binding]; other site 266779000954 Q-loop/lid; other site 266779000955 ABC transporter signature motif; other site 266779000956 Walker B; other site 266779000957 D-loop; other site 266779000958 H-loop/switch region; other site 266779000959 TOBE domain; Region: TOBE_2; pfam08402 266779000960 hypothetical protein; Validated; Region: PRK08245 266779000961 Domain of unknown function (DUF336); Region: DUF336; cl01249 266779000962 classical (c) SDRs; Region: SDR_c; cd05233 266779000963 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 266779000964 NAD(P) binding site [chemical binding]; other site 266779000965 active site 266779000966 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266779000967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779000968 dimer interface [polypeptide binding]; other site 266779000969 conserved gate region; other site 266779000970 putative PBP binding loops; other site 266779000971 ABC-ATPase subunit interface; other site 266779000972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779000973 dimer interface [polypeptide binding]; other site 266779000974 conserved gate region; other site 266779000975 putative PBP binding loops; other site 266779000976 ABC-ATPase subunit interface; other site 266779000977 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266779000978 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266779000979 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266779000980 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779000981 DNA-binding site [nucleotide binding]; DNA binding site 266779000982 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266779000983 D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312 266779000984 mannonate dehydratase; Region: uxuA; TIGR00695 266779000985 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266779000986 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266779000987 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266779000988 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266779000989 active site pocket [active] 266779000990 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266779000991 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 266779000992 putative NAD(P) binding site [chemical binding]; other site 266779000993 putative active site [active] 266779000994 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 266779000995 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266779000996 putative ligand binding site [chemical binding]; other site 266779000997 NAD binding site [chemical binding]; other site 266779000998 catalytic site [active] 266779000999 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266779001000 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779001001 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266779001002 dimerization interface [polypeptide binding]; other site 266779001003 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266779001004 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266779001005 substrate binding pocket [chemical binding]; other site 266779001006 membrane-bound complex binding site; other site 266779001007 hinge residues; other site 266779001008 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266779001009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779001010 dimer interface [polypeptide binding]; other site 266779001011 conserved gate region; other site 266779001012 putative PBP binding loops; other site 266779001013 ABC-ATPase subunit interface; other site 266779001014 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266779001015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779001016 dimer interface [polypeptide binding]; other site 266779001017 conserved gate region; other site 266779001018 putative PBP binding loops; other site 266779001019 ABC-ATPase subunit interface; other site 266779001020 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266779001021 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266779001022 Walker A/P-loop; other site 266779001023 ATP binding site [chemical binding]; other site 266779001024 Q-loop/lid; other site 266779001025 ABC transporter signature motif; other site 266779001026 Walker B; other site 266779001027 D-loop; other site 266779001028 H-loop/switch region; other site 266779001029 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 266779001030 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266779001031 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779001032 putative DNA binding site [nucleotide binding]; other site 266779001033 putative Zn2+ binding site [ion binding]; other site 266779001034 Bacterial transcriptional regulator; Region: IclR; pfam01614 266779001035 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266779001036 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266779001037 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266779001038 active site pocket [active] 266779001039 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266779001040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779001041 Walker A/P-loop; other site 266779001042 ATP binding site [chemical binding]; other site 266779001043 Q-loop/lid; other site 266779001044 ABC transporter signature motif; other site 266779001045 Walker B; other site 266779001046 D-loop; other site 266779001047 H-loop/switch region; other site 266779001048 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 266779001049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779001050 dimer interface [polypeptide binding]; other site 266779001051 conserved gate region; other site 266779001052 putative PBP binding loops; other site 266779001053 ABC-ATPase subunit interface; other site 266779001054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779001055 dimer interface [polypeptide binding]; other site 266779001056 conserved gate region; other site 266779001057 putative PBP binding loops; other site 266779001058 ABC-ATPase subunit interface; other site 266779001059 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266779001060 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266779001061 galactonate dehydratase; Provisional; Region: PRK14017 266779001062 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266779001063 active site pocket [active] 266779001064 tartrate dehydrogenase; Region: TTC; TIGR02089 266779001065 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 266779001066 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266779001067 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 266779001068 putative active site pocket [active] 266779001069 metal binding site [ion binding]; metal-binding site 266779001070 cell density-dependent motility repressor; Provisional; Region: PRK10082 266779001071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779001072 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266779001073 dimerization interface [polypeptide binding]; other site 266779001074 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 266779001075 MerR family regulatory protein; Region: MerR; pfam00376 266779001076 DNA binding residues [nucleotide binding] 266779001077 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266779001078 P-loop; other site 266779001079 Magnesium ion binding site [ion binding]; other site 266779001080 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266779001081 Magnesium ion binding site [ion binding]; other site 266779001082 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 266779001083 ParB-like nuclease domain; Region: ParB; smart00470 266779001084 replication initiation protein RepC; Provisional; Region: PRK13824 266779001085 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779001086 putative DNA binding site [nucleotide binding]; other site 266779001087 putative Zn2+ binding site [ion binding]; other site 266779001088 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 266779001089 RES domain; Region: RES; cl02411 266779001090 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 266779001091 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 266779001092 DNA binding site [nucleotide binding] 266779001093 dimer interface [polypeptide binding]; other site 266779001094 active site 266779001095 Int/Topo IB signature motif; other site 266779001096 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 266779001097 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 266779001098 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 266779001099 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 266779001100 putative active site [active] 266779001101 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 266779001102 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 266779001103 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266779001104 multiple promoter invertase; Provisional; Region: mpi; PRK13413 266779001105 catalytic residues [active] 266779001106 catalytic nucleophile [active] 266779001107 Presynaptic Site I dimer interface [polypeptide binding]; other site 266779001108 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266779001109 Synaptic Flat tetramer interface [polypeptide binding]; other site 266779001110 Synaptic Site I dimer interface [polypeptide binding]; other site 266779001111 DNA binding site [nucleotide binding] 266779001112 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266779001113 DNA-binding interface [nucleotide binding]; DNA binding site 266779001114 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 266779001115 Integrase core domain; Region: rve; pfam00665 266779001116 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266779001117 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266779001118 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266779001119 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266779001120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779001121 DNA-binding site [nucleotide binding]; DNA binding site 266779001122 FCD domain; Region: FCD; pfam07729 266779001123 dihydroxy-acid dehydratase; Validated; Region: PRK06131 266779001124 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 266779001125 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266779001126 ATP binding site [chemical binding]; other site 266779001127 putative Mg++ binding site [ion binding]; other site 266779001128 nucleotide binding region [chemical binding]; other site 266779001129 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 266779001130 ATP-binding site [chemical binding]; other site 266779001131 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 266779001132 Protein of unknown function DUF262; Region: DUF262; pfam03235 266779001133 Uncharacterized conserved protein [Function unknown]; Region: COG1479 266779001134 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 266779001135 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 266779001136 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 266779001137 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266779001138 catalytic residue [active] 266779001139 DNA sulfur modification protein DndE; Region: DNA_S_dndE; TIGR03184 266779001140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779001141 AAA domain; Region: AAA_23; pfam13476 266779001142 Walker A/P-loop; other site 266779001143 ATP binding site [chemical binding]; other site 266779001144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779001145 ABC transporter signature motif; other site 266779001146 Walker B; other site 266779001147 D-loop; other site 266779001148 H-loop/switch region; other site 266779001149 hypothetical protein; Provisional; Region: PRK06850 266779001150 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 266779001151 Active Sites [active] 266779001152 DNA-sulfur modification-associated; Region: DndB; pfam14072 266779001153 DGQHR domain; Region: DGQHR; TIGR03187 266779001154 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 266779001155 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 266779001156 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 266779001157 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 266779001158 DNA binding site [nucleotide binding] 266779001159 dimer interface [polypeptide binding]; other site 266779001160 active site 266779001161 Int/Topo IB signature motif; other site 266779001162 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 266779001163 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 266779001164 oligomeric interface; other site 266779001165 putative active site [active] 266779001166 homodimer interface [polypeptide binding]; other site 266779001167 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 266779001168 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 266779001169 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266779001170 P-loop; other site 266779001171 Magnesium ion binding site [ion binding]; other site 266779001172 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 266779001173 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266779001174 Magnesium ion binding site [ion binding]; other site 266779001175 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 266779001176 ParB-like nuclease domain; Region: ParB; smart00470 266779001177 replication initiation protein RepC; Provisional; Region: PRK13824 266779001178 Replication protein C N-terminal domain; Region: RP-C; pfam03428 266779001179 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 266779001180 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266779001181 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266779001182 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 266779001183 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 266779001184 ParB-like nuclease domain; Region: ParBc; cl02129 266779001185 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 266779001186 Protein of unknown function (DUF1419); Region: DUF1419; pfam07215 266779001187 Antirestriction protein; Region: Antirestrict; pfam03230 266779001188 Methyltransferase domain; Region: Methyltransf_26; pfam13659 266779001189 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 266779001190 Bacterial TniB protein; Region: TniB; pfam05621 266779001191 AAA domain; Region: AAA_22; pfam13401 266779001192 Helix-turn-helix domain; Region: HTH_28; pfam13518 266779001193 Winged helix-turn helix; Region: HTH_29; pfam13551 266779001194 Integrase core domain; Region: rve; pfam00665 266779001195 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 266779001196 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266779001197 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266779001198 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 266779001199 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266779001200 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 266779001201 NAD(P) binding site [chemical binding]; other site 266779001202 catalytic residues [active] 266779001203 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266779001204 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 266779001205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266779001206 non-specific DNA binding site [nucleotide binding]; other site 266779001207 salt bridge; other site 266779001208 sequence-specific DNA binding site [nucleotide binding]; other site 266779001209 Cupin domain; Region: Cupin_2; pfam07883 266779001210 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 266779001211 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 266779001212 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 266779001213 DnaA N-terminal domain; Region: DnaA_N; pfam11638 266779001214 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 266779001215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 266779001216 Walker A motif; other site 266779001217 ATP binding site [chemical binding]; other site 266779001218 Walker B motif; other site 266779001219 arginine finger; other site 266779001220 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 266779001221 DnaA box-binding interface [nucleotide binding]; other site 266779001222 DNA polymerase III subunit beta; Validated; Region: PRK05643 266779001223 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 266779001224 putative DNA binding surface [nucleotide binding]; other site 266779001225 dimer interface [polypeptide binding]; other site 266779001226 beta-clamp/clamp loader binding surface; other site 266779001227 beta-clamp/translesion DNA polymerase binding surface; other site 266779001228 recombination protein F; Reviewed; Region: recF; PRK00064 266779001229 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 266779001230 Walker A/P-loop; other site 266779001231 ATP binding site [chemical binding]; other site 266779001232 Q-loop/lid; other site 266779001233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779001234 ABC transporter signature motif; other site 266779001235 Walker B; other site 266779001236 D-loop; other site 266779001237 H-loop/switch region; other site 266779001238 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 266779001239 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 266779001240 ATP binding site [chemical binding]; other site 266779001241 substrate interface [chemical binding]; other site 266779001242 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 266779001243 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 266779001244 substrate binding site [chemical binding]; other site 266779001245 hexamer interface [polypeptide binding]; other site 266779001246 metal binding site [ion binding]; metal-binding site 266779001247 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 266779001248 putative hydrophobic ligand binding site [chemical binding]; other site 266779001249 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 266779001250 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 266779001251 dimerization interface [polypeptide binding]; other site 266779001252 domain crossover interface; other site 266779001253 redox-dependent activation switch; other site 266779001254 ornithine carbamoyltransferase; Provisional; Region: PRK00779 266779001255 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266779001256 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 266779001257 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 266779001258 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266779001259 inhibitor-cofactor binding pocket; inhibition site 266779001260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779001261 catalytic residue [active] 266779001262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352 266779001263 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 266779001264 PhoU domain; Region: PhoU; pfam01895 266779001265 PhoU domain; Region: PhoU; pfam01895 266779001266 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266779001267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779001268 dimer interface [polypeptide binding]; other site 266779001269 phosphorylation site [posttranslational modification] 266779001270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779001271 ATP binding site [chemical binding]; other site 266779001272 Mg2+ binding site [ion binding]; other site 266779001273 G-X-G motif; other site 266779001274 Uncharacterized conserved protein [Function unknown]; Region: COG2326 266779001275 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 266779001276 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 266779001277 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266779001278 DXD motif; other site 266779001279 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266779001280 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266779001281 substrate binding pocket [chemical binding]; other site 266779001282 membrane-bound complex binding site; other site 266779001283 hinge residues; other site 266779001284 tellurite resistance protein terB; Region: terB; cd07176 266779001285 putative metal binding site [ion binding]; other site 266779001286 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 266779001287 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266779001288 active site 266779001289 nucleotide binding site [chemical binding]; other site 266779001290 HIGH motif; other site 266779001291 KMSKS motif; other site 266779001292 Predicted transcriptional regulator [Transcription]; Region: COG2932 266779001293 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 266779001294 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 266779001295 Catalytic site [active] 266779001296 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 266779001297 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 266779001298 putative catalytic residue [active] 266779001299 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266779001300 active site 266779001301 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 266779001302 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266779001303 substrate binding site [chemical binding]; other site 266779001304 oxyanion hole (OAH) forming residues; other site 266779001305 trimer interface [polypeptide binding]; other site 266779001306 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266779001307 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266779001308 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266779001309 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 266779001310 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266779001311 dimer interface [polypeptide binding]; other site 266779001312 active site 266779001313 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 266779001314 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 266779001315 FAD binding site [chemical binding]; other site 266779001316 substrate binding site [chemical binding]; other site 266779001317 catalytic residues [active] 266779001318 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 266779001319 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 266779001320 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 266779001321 DNA binding residues [nucleotide binding] 266779001322 putative dimer interface [polypeptide binding]; other site 266779001323 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266779001324 Sel1-like repeats; Region: SEL1; smart00671 266779001325 Sel1-like repeats; Region: SEL1; smart00671 266779001326 Sel1-like repeats; Region: SEL1; smart00671 266779001327 Sel1-like repeats; Region: SEL1; smart00671 266779001328 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266779001329 Predicted permeases [General function prediction only]; Region: COG0730 266779001330 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 266779001331 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266779001332 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 266779001333 putative active site [active] 266779001334 putative metal binding site [ion binding]; other site 266779001335 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 266779001336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266779001337 ATP binding site [chemical binding]; other site 266779001338 putative Mg++ binding site [ion binding]; other site 266779001339 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266779001340 nucleotide binding region [chemical binding]; other site 266779001341 ATP-binding site [chemical binding]; other site 266779001342 DEAD/H associated; Region: DEAD_assoc; pfam08494 266779001343 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 266779001344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779001345 S-adenosylmethionine binding site [chemical binding]; other site 266779001346 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 266779001347 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266779001348 ATP-dependent DNA ligase; Validated; Region: PRK09247 266779001349 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 266779001350 active site 266779001351 DNA binding site [nucleotide binding] 266779001352 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 266779001353 DNA binding site [nucleotide binding] 266779001354 ATP synthase A chain; Region: ATP-synt_A; cl00413 266779001355 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 266779001356 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 266779001357 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779001358 Walker A/P-loop; other site 266779001359 ATP binding site [chemical binding]; other site 266779001360 Q-loop/lid; other site 266779001361 ABC transporter signature motif; other site 266779001362 Walker B; other site 266779001363 D-loop; other site 266779001364 H-loop/switch region; other site 266779001365 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779001366 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779001367 Walker A/P-loop; other site 266779001368 ATP binding site [chemical binding]; other site 266779001369 Q-loop/lid; other site 266779001370 ABC transporter signature motif; other site 266779001371 Walker B; other site 266779001372 D-loop; other site 266779001373 H-loop/switch region; other site 266779001374 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779001375 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266779001376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779001377 dimer interface [polypeptide binding]; other site 266779001378 conserved gate region; other site 266779001379 ABC-ATPase subunit interface; other site 266779001380 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 266779001381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779001382 dimer interface [polypeptide binding]; other site 266779001383 conserved gate region; other site 266779001384 putative PBP binding loops; other site 266779001385 ABC-ATPase subunit interface; other site 266779001386 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 266779001387 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 266779001388 peptide binding site [polypeptide binding]; other site 266779001389 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266779001390 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266779001391 Walker A/P-loop; other site 266779001392 ATP binding site [chemical binding]; other site 266779001393 Q-loop/lid; other site 266779001394 ABC transporter signature motif; other site 266779001395 Walker B; other site 266779001396 D-loop; other site 266779001397 H-loop/switch region; other site 266779001398 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266779001399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779001400 dimer interface [polypeptide binding]; other site 266779001401 conserved gate region; other site 266779001402 putative PBP binding loops; other site 266779001403 ABC-ATPase subunit interface; other site 266779001404 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266779001405 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266779001406 substrate binding pocket [chemical binding]; other site 266779001407 membrane-bound complex binding site; other site 266779001408 hinge residues; other site 266779001409 Predicted amidohydrolase [General function prediction only]; Region: COG0388 266779001410 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 266779001411 putative active site [active] 266779001412 catalytic triad [active] 266779001413 putative dimer interface [polypeptide binding]; other site 266779001414 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266779001415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779001416 DNA-binding site [nucleotide binding]; DNA binding site 266779001417 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266779001418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779001419 homodimer interface [polypeptide binding]; other site 266779001420 catalytic residue [active] 266779001421 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 266779001422 Domain of unknown function DUF11; Region: DUF11; cl17728 266779001423 Domain of unknown function DUF11; Region: DUF11; cl17728 266779001424 Domain of unknown function DUF11; Region: DUF11; pfam01345 266779001425 Domain of unknown function DUF11; Region: DUF11; cl17728 266779001426 conserved repeat domain; Region: B_ant_repeat; TIGR01451 266779001427 DctM-like transporters; Region: DctM; pfam06808 266779001428 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 266779001429 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 266779001430 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266779001431 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 266779001432 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266779001433 Bacterial transcriptional regulator; Region: IclR; pfam01614 266779001434 salicylate hydroxylase; Provisional; Region: PRK08163 266779001435 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266779001436 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 266779001437 Cupin domain; Region: Cupin_2; pfam07883 266779001438 Cupin domain; Region: Cupin_2; cl17218 266779001439 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266779001440 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266779001441 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 266779001442 maleylacetoacetate isomerase; Region: maiA; TIGR01262 266779001443 C-terminal domain interface [polypeptide binding]; other site 266779001444 GSH binding site (G-site) [chemical binding]; other site 266779001445 putative dimer interface [polypeptide binding]; other site 266779001446 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 266779001447 N-terminal domain interface [polypeptide binding]; other site 266779001448 dimer interface [polypeptide binding]; other site 266779001449 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 266779001450 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 266779001451 Fumarase C-terminus; Region: Fumerase_C; pfam05683 266779001452 outer membrane protease; Reviewed; Region: PRK10993 266779001453 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266779001454 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266779001455 catalytic loop [active] 266779001456 iron binding site [ion binding]; other site 266779001457 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266779001458 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266779001459 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266779001460 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266779001461 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266779001462 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 266779001463 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 266779001464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779001465 putative substrate translocation pore; other site 266779001466 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266779001467 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779001468 Walker A/P-loop; other site 266779001469 ATP binding site [chemical binding]; other site 266779001470 Q-loop/lid; other site 266779001471 ABC transporter signature motif; other site 266779001472 Walker B; other site 266779001473 D-loop; other site 266779001474 H-loop/switch region; other site 266779001475 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266779001476 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266779001477 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779001478 Walker A/P-loop; other site 266779001479 ATP binding site [chemical binding]; other site 266779001480 Q-loop/lid; other site 266779001481 ABC transporter signature motif; other site 266779001482 Walker B; other site 266779001483 D-loop; other site 266779001484 H-loop/switch region; other site 266779001485 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266779001486 dipeptide transporter; Provisional; Region: PRK10913 266779001487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779001488 dimer interface [polypeptide binding]; other site 266779001489 conserved gate region; other site 266779001490 putative PBP binding loops; other site 266779001491 ABC-ATPase subunit interface; other site 266779001492 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779001493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779001494 dimer interface [polypeptide binding]; other site 266779001495 conserved gate region; other site 266779001496 putative PBP binding loops; other site 266779001497 ABC-ATPase subunit interface; other site 266779001498 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266779001499 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 266779001500 peptide binding site [polypeptide binding]; other site 266779001501 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 266779001502 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 266779001503 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 266779001504 acyl-activating enzyme (AAE) consensus motif; other site 266779001505 putative AMP binding site [chemical binding]; other site 266779001506 putative active site [active] 266779001507 putative CoA binding site [chemical binding]; other site 266779001508 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 266779001509 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 266779001510 active site 266779001511 dimer interface [polypeptide binding]; other site 266779001512 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 266779001513 dimer interface [polypeptide binding]; other site 266779001514 active site 266779001515 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266779001516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779001517 DNA-binding site [nucleotide binding]; DNA binding site 266779001518 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266779001519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779001520 homodimer interface [polypeptide binding]; other site 266779001521 catalytic residue [active] 266779001522 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 266779001523 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 266779001524 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266779001525 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 266779001526 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779001527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779001528 dimer interface [polypeptide binding]; other site 266779001529 conserved gate region; other site 266779001530 putative PBP binding loops; other site 266779001531 ABC-ATPase subunit interface; other site 266779001532 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266779001533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779001534 dimer interface [polypeptide binding]; other site 266779001535 conserved gate region; other site 266779001536 putative PBP binding loops; other site 266779001537 ABC-ATPase subunit interface; other site 266779001538 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266779001539 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779001540 Walker A/P-loop; other site 266779001541 ATP binding site [chemical binding]; other site 266779001542 Q-loop/lid; other site 266779001543 ABC transporter signature motif; other site 266779001544 Walker B; other site 266779001545 D-loop; other site 266779001546 H-loop/switch region; other site 266779001547 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266779001548 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779001549 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 266779001550 Walker A/P-loop; other site 266779001551 ATP binding site [chemical binding]; other site 266779001552 Q-loop/lid; other site 266779001553 ABC transporter signature motif; other site 266779001554 Walker B; other site 266779001555 D-loop; other site 266779001556 H-loop/switch region; other site 266779001557 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779001558 Creatinine amidohydrolase; Region: Creatininase; pfam02633 266779001559 nitrilase; Region: PLN02798 266779001560 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 266779001561 putative active site [active] 266779001562 catalytic triad [active] 266779001563 dimer interface [polypeptide binding]; other site 266779001564 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779001565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779001566 LysR substrate binding domain; Region: LysR_substrate; pfam03466 266779001567 dimerization interface [polypeptide binding]; other site 266779001568 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266779001569 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266779001570 active site 266779001571 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266779001572 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266779001573 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266779001574 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 266779001575 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 266779001576 substrate-cofactor binding pocket; other site 266779001577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779001578 catalytic residue [active] 266779001579 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 266779001580 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 266779001581 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 266779001582 Na binding site [ion binding]; other site 266779001583 PAS fold; Region: PAS_7; pfam12860 266779001584 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266779001585 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779001586 dimer interface [polypeptide binding]; other site 266779001587 phosphorylation site [posttranslational modification] 266779001588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779001589 ATP binding site [chemical binding]; other site 266779001590 Mg2+ binding site [ion binding]; other site 266779001591 G-X-G motif; other site 266779001592 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266779001593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779001594 active site 266779001595 phosphorylation site [posttranslational modification] 266779001596 intermolecular recognition site; other site 266779001597 dimerization interface [polypeptide binding]; other site 266779001598 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266779001599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779001600 active site 266779001601 phosphorylation site [posttranslational modification] 266779001602 intermolecular recognition site; other site 266779001603 dimerization interface [polypeptide binding]; other site 266779001604 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266779001605 DNA binding residues [nucleotide binding] 266779001606 dimerization interface [polypeptide binding]; other site 266779001607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 266779001608 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 266779001609 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 266779001610 quinone interaction residues [chemical binding]; other site 266779001611 active site 266779001612 catalytic residues [active] 266779001613 FMN binding site [chemical binding]; other site 266779001614 substrate binding site [chemical binding]; other site 266779001615 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 266779001616 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 266779001617 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 266779001618 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 266779001619 trimer interface [polypeptide binding]; other site 266779001620 active site 266779001621 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 266779001622 trimer interface [polypeptide binding]; other site 266779001623 active site 266779001624 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 266779001625 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266779001626 homodimer interface [polypeptide binding]; other site 266779001627 substrate-cofactor binding pocket; other site 266779001628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779001629 catalytic residue [active] 266779001630 Right handed beta helix region; Region: Beta_helix; pfam13229 266779001631 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 266779001632 phosphopeptide binding site; other site 266779001633 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 266779001634 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 266779001635 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 266779001636 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 266779001637 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 266779001638 Walker A motif/ATP binding site; other site 266779001639 Walker B motif; other site 266779001640 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 266779001641 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 266779001642 type III secretion system protein YscR; Provisional; Region: PRK12797 266779001643 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 266779001644 Bacterial export proteins, family 1; Region: Bac_export_1; pfam01311 266779001645 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 266779001646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266779001647 binding surface 266779001648 TPR motif; other site 266779001649 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266779001650 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266779001651 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266779001652 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 266779001653 FHIPEP family; Region: FHIPEP; pfam00771 266779001654 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779001655 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779001656 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266779001657 dimerization interface [polypeptide binding]; other site 266779001658 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266779001659 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266779001660 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 266779001661 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 266779001662 active site 266779001663 Zn binding site [ion binding]; other site 266779001664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266779001665 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 266779001666 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 266779001667 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266779001668 HlyD family secretion protein; Region: HlyD_3; pfam13437 266779001669 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266779001670 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 266779001671 Walker A/P-loop; other site 266779001672 ATP binding site [chemical binding]; other site 266779001673 Q-loop/lid; other site 266779001674 ABC transporter signature motif; other site 266779001675 Walker B; other site 266779001676 D-loop; other site 266779001677 H-loop/switch region; other site 266779001678 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 266779001679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779001680 Walker A/P-loop; other site 266779001681 ATP binding site [chemical binding]; other site 266779001682 Q-loop/lid; other site 266779001683 ABC transporter signature motif; other site 266779001684 Walker B; other site 266779001685 D-loop; other site 266779001686 H-loop/switch region; other site 266779001687 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266779001688 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 266779001689 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266779001690 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 266779001691 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 266779001692 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 266779001693 siderophore binding site; other site 266779001694 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 266779001695 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266779001696 ABC-ATPase subunit interface; other site 266779001697 dimer interface [polypeptide binding]; other site 266779001698 putative PBP binding regions; other site 266779001699 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 266779001700 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266779001701 ABC-ATPase subunit interface; other site 266779001702 dimer interface [polypeptide binding]; other site 266779001703 putative PBP binding regions; other site 266779001704 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 266779001705 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 266779001706 Walker A/P-loop; other site 266779001707 ATP binding site [chemical binding]; other site 266779001708 Q-loop/lid; other site 266779001709 ABC transporter signature motif; other site 266779001710 Walker B; other site 266779001711 D-loop; other site 266779001712 H-loop/switch region; other site 266779001713 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 266779001714 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 266779001715 Autotransporter beta-domain; Region: Autotransporter; smart00869 266779001716 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 266779001717 dimer interface [polypeptide binding]; other site 266779001718 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 266779001719 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 266779001720 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 266779001721 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 266779001722 putative active site [active] 266779001723 putative metal binding site [ion binding]; other site 266779001724 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 266779001725 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 266779001726 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 266779001727 PhoU domain; Region: PhoU; pfam01895 266779001728 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266779001729 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266779001730 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266779001731 Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813 266779001732 conserved cys residue [active] 266779001733 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 266779001734 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 266779001735 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266779001736 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266779001737 DNA binding residues [nucleotide binding] 266779001738 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 266779001739 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 266779001740 Uncharacterized conserved protein [Function unknown]; Region: COG2353 266779001741 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 266779001742 purine nucleoside phosphorylase; Provisional; Region: PRK08202 266779001743 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 266779001744 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 266779001745 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 266779001746 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 266779001747 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 266779001748 homodimer interface [polypeptide binding]; other site 266779001749 NADP binding site [chemical binding]; other site 266779001750 substrate binding site [chemical binding]; other site 266779001751 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 266779001752 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 266779001753 Chromate transporter; Region: Chromate_transp; pfam02417 266779001754 Sulfatase; Region: Sulfatase; cl17466 266779001755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779001756 S-adenosylmethionine binding site [chemical binding]; other site 266779001757 6-phosphogluconate dehydratase; Region: edd; TIGR01196 266779001758 phosphogluconate dehydratase; Validated; Region: PRK09054 266779001759 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 266779001760 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 266779001761 putative active site [active] 266779001762 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 266779001763 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 266779001764 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 266779001765 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266779001766 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266779001767 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 266779001768 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266779001769 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266779001770 cheY-homologous receiver domain; Region: REC; smart00448 266779001771 active site 266779001772 phosphorylation site [posttranslational modification] 266779001773 intermolecular recognition site; other site 266779001774 dimerization interface [polypeptide binding]; other site 266779001775 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 266779001776 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266779001777 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266779001778 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 266779001779 Walker A/P-loop; other site 266779001780 ATP binding site [chemical binding]; other site 266779001781 Q-loop/lid; other site 266779001782 ABC transporter signature motif; other site 266779001783 Walker B; other site 266779001784 D-loop; other site 266779001785 H-loop/switch region; other site 266779001786 TOBE domain; Region: TOBE_2; pfam08402 266779001787 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 266779001788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779001789 dimer interface [polypeptide binding]; other site 266779001790 conserved gate region; other site 266779001791 putative PBP binding loops; other site 266779001792 ABC-ATPase subunit interface; other site 266779001793 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266779001794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779001795 dimer interface [polypeptide binding]; other site 266779001796 conserved gate region; other site 266779001797 putative PBP binding loops; other site 266779001798 ABC-ATPase subunit interface; other site 266779001799 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 266779001800 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 266779001801 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 266779001802 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 266779001803 acyl-activating enzyme (AAE) consensus motif; other site 266779001804 putative AMP binding site [chemical binding]; other site 266779001805 putative active site [active] 266779001806 putative CoA binding site [chemical binding]; other site 266779001807 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 266779001808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779001809 ABC-ATPase subunit interface; other site 266779001810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779001811 dimer interface [polypeptide binding]; other site 266779001812 conserved gate region; other site 266779001813 putative PBP binding loops; other site 266779001814 ABC-ATPase subunit interface; other site 266779001815 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 266779001816 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266779001817 PAS domain; Region: PAS_9; pfam13426 266779001818 PAS domain; Region: PAS_8; pfam13188 266779001819 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266779001820 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266779001821 putative active site [active] 266779001822 heme pocket [chemical binding]; other site 266779001823 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779001824 dimer interface [polypeptide binding]; other site 266779001825 phosphorylation site [posttranslational modification] 266779001826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779001827 ATP binding site [chemical binding]; other site 266779001828 Mg2+ binding site [ion binding]; other site 266779001829 G-X-G motif; other site 266779001830 Phasin protein; Region: Phasin_2; cl11491 266779001831 Uncharacterized conserved protein [Function unknown]; Region: COG5276 266779001832 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266779001833 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266779001834 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266779001835 putative active site [active] 266779001836 hypothetical protein; Provisional; Region: PRK07483 266779001837 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266779001838 inhibitor-cofactor binding pocket; inhibition site 266779001839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779001840 catalytic residue [active] 266779001841 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 266779001842 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 266779001843 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 266779001844 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 266779001845 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 266779001846 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266779001847 Ligand Binding Site [chemical binding]; other site 266779001848 PAS fold; Region: PAS_4; pfam08448 266779001849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266779001850 HWE histidine kinase; Region: HWE_HK; smart00911 266779001851 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 266779001852 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 266779001853 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 266779001854 generic binding surface II; other site 266779001855 generic binding surface I; other site 266779001856 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779001857 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779001858 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266779001859 dimerization interface [polypeptide binding]; other site 266779001860 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 266779001861 zinc-binding protein; Provisional; Region: PRK01343 266779001862 Maf-like protein; Region: Maf; pfam02545 266779001863 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 266779001864 active site 266779001865 dimer interface [polypeptide binding]; other site 266779001866 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 266779001867 rRNA binding site [nucleotide binding]; other site 266779001868 predicted 30S ribosome binding site; other site 266779001869 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 266779001870 Low molecular weight phosphatase family; Region: LMWPc; cl00105 266779001871 active site 266779001872 Uncharacterized protein family (UPF0262); Region: UPF0262; pfam06793 266779001873 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 266779001874 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 266779001875 NAD binding site [chemical binding]; other site 266779001876 dimerization interface [polypeptide binding]; other site 266779001877 product binding site; other site 266779001878 substrate binding site [chemical binding]; other site 266779001879 zinc binding site [ion binding]; other site 266779001880 catalytic residues [active] 266779001881 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 266779001882 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 266779001883 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 266779001884 hinge; other site 266779001885 active site 266779001886 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266779001887 active site 266779001888 catalytic residues [active] 266779001889 DNA binding site [nucleotide binding] 266779001890 Int/Topo IB signature motif; other site 266779001891 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 266779001892 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266779001893 active site 266779001894 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 266779001895 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 266779001896 dimer interface [polypeptide binding]; other site 266779001897 ssDNA binding site [nucleotide binding]; other site 266779001898 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266779001899 Helix-turn-helix domain; Region: HTH_36; pfam13730 266779001900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266779001901 non-specific DNA binding site [nucleotide binding]; other site 266779001902 salt bridge; other site 266779001903 sequence-specific DNA binding site [nucleotide binding]; other site 266779001904 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 266779001905 Catalytic site [active] 266779001906 T5orf172 domain; Region: T5orf172; pfam10544 266779001907 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 266779001908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 266779001909 Terminase-like family; Region: Terminase_6; pfam03237 266779001910 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 266779001911 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 266779001912 HNH endonuclease; Region: HNH_3; pfam13392 266779001913 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266779001914 DNA-binding interface [nucleotide binding]; DNA binding site 266779001915 HNH endonuclease; Region: HNH_3; pfam13392 266779001916 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266779001917 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 266779001918 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 266779001919 Phage Tail Collar Domain; Region: Collar; pfam07484 266779001920 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 266779001921 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 266779001922 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266779001923 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266779001924 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 266779001925 putative lipid kinase; Reviewed; Region: PRK13057 266779001926 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266779001927 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779001928 DNA-binding site [nucleotide binding]; DNA binding site 266779001929 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266779001930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779001931 homodimer interface [polypeptide binding]; other site 266779001932 catalytic residue [active] 266779001933 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266779001934 PrkA family serine protein kinase; Provisional; Region: PRK15455 266779001935 AAA ATPase domain; Region: AAA_16; pfam13191 266779001936 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 266779001937 hypothetical protein; Provisional; Region: PRK05325 266779001938 SpoVR family protein; Provisional; Region: PRK11767 266779001939 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 266779001940 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 266779001941 Transglycosylase; Region: Transgly; pfam00912 266779001942 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 266779001943 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 266779001944 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 266779001945 putative binding site; other site 266779001946 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 266779001947 MG2 domain; Region: A2M_N; pfam01835 266779001948 Alpha-2-macroglobulin family; Region: A2M; pfam00207 266779001949 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 266779001950 surface patch; other site 266779001951 thioester region; other site 266779001952 specificity defining residues; other site 266779001953 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 266779001954 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 266779001955 NADP binding site [chemical binding]; other site 266779001956 homodimer interface [polypeptide binding]; other site 266779001957 active site 266779001958 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266779001959 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266779001960 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 266779001961 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266779001962 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266779001963 DNA binding site [nucleotide binding] 266779001964 domain linker motif; other site 266779001965 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 266779001966 dimerization interface [polypeptide binding]; other site 266779001967 ligand binding site [chemical binding]; other site 266779001968 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266779001969 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266779001970 TM-ABC transporter signature motif; other site 266779001971 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266779001972 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266779001973 TM-ABC transporter signature motif; other site 266779001974 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266779001975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779001976 Walker A/P-loop; other site 266779001977 ATP binding site [chemical binding]; other site 266779001978 Q-loop/lid; other site 266779001979 ABC transporter signature motif; other site 266779001980 Walker B; other site 266779001981 D-loop; other site 266779001982 H-loop/switch region; other site 266779001983 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266779001984 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 266779001985 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266779001986 putative ligand binding site [chemical binding]; other site 266779001987 Rod binding protein; Region: Rod-binding; pfam10135 266779001988 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 266779001989 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 266779001990 FHIPEP family; Region: FHIPEP; pfam00771 266779001991 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 266779001992 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 266779001993 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 266779001994 flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794 266779001995 Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442 266779001996 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 266779001997 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 266779001998 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266779001999 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 266779002000 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 266779002001 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266779002002 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 266779002003 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 266779002004 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 266779002005 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266779002006 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266779002007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779002008 active site 266779002009 intermolecular recognition site; other site 266779002010 dimerization interface [polypeptide binding]; other site 266779002011 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266779002012 DNA binding site [nucleotide binding] 266779002013 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266779002014 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266779002015 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266779002016 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 266779002017 chemotaxis protein; Reviewed; Region: PRK12798 266779002018 flagellar motor protein MotB; Validated; Region: motB; PRK05996 266779002019 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 266779002020 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266779002021 ligand binding site [chemical binding]; other site 266779002022 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 266779002023 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 266779002024 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 266779002025 flagellin; Reviewed; Region: PRK12687 266779002026 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266779002027 flagellin; Reviewed; Region: PRK12687 266779002028 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266779002029 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 266779002030 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 266779002031 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 266779002032 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 266779002033 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 266779002034 Uncharacterized conserved protein [Function unknown]; Region: COG3334 266779002035 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 266779002036 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 266779002037 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 266779002038 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 266779002039 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 266779002040 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266779002041 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 266779002042 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 266779002043 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266779002044 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 266779002045 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 266779002046 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266779002047 Walker A motif; other site 266779002048 ATP binding site [chemical binding]; other site 266779002049 Walker B motif; other site 266779002050 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 266779002051 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 266779002052 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 266779002053 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 266779002054 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 266779002055 flagellar motor protein MotA; Validated; Region: PRK09110 266779002056 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 266779002057 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 266779002058 flagellar motor switch protein FliN; Region: fliN; TIGR02480 266779002059 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 266779002060 FliG C-terminal domain; Region: FliG_C; pfam01706 266779002061 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 266779002062 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 266779002063 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 266779002064 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266779002065 tetramer interface [polypeptide binding]; other site 266779002066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779002067 catalytic residue [active] 266779002068 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266779002069 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266779002070 non-specific DNA binding site [nucleotide binding]; other site 266779002071 salt bridge; other site 266779002072 sequence-specific DNA binding site [nucleotide binding]; other site 266779002073 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 266779002074 Domain of unknown function (DUF955); Region: DUF955; pfam06114 266779002075 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 266779002076 isocitrate lyase; Provisional; Region: PRK15063 266779002077 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266779002078 tetramer interface [polypeptide binding]; other site 266779002079 active site 266779002080 Mg2+/Mn2+ binding site [ion binding]; other site 266779002081 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 266779002082 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266779002083 NAD(P) binding site [chemical binding]; other site 266779002084 catalytic residues [active] 266779002085 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266779002086 NAD(P) binding site [chemical binding]; other site 266779002087 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 266779002088 intersubunit interface [polypeptide binding]; other site 266779002089 active site 266779002090 catalytic residue [active] 266779002091 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266779002092 EamA-like transporter family; Region: EamA; pfam00892 266779002093 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 266779002094 ATP-binding site [chemical binding]; other site 266779002095 Gluconate-6-phosphate binding site [chemical binding]; other site 266779002096 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 266779002097 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 266779002098 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 266779002099 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 266779002100 RNA binding site [nucleotide binding]; other site 266779002101 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 266779002102 septum formation inhibitor; Reviewed; Region: minC; PRK05177 266779002103 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 266779002104 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 266779002105 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 266779002106 Switch I; other site 266779002107 Switch II; other site 266779002108 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 266779002109 putative S-transferase; Provisional; Region: PRK11752 266779002110 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 266779002111 C-terminal domain interface [polypeptide binding]; other site 266779002112 GSH binding site (G-site) [chemical binding]; other site 266779002113 dimer interface [polypeptide binding]; other site 266779002114 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 266779002115 dimer interface [polypeptide binding]; other site 266779002116 N-terminal domain interface [polypeptide binding]; other site 266779002117 active site 266779002118 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 266779002119 arsenical-resistance protein; Region: acr3; TIGR00832 266779002120 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 266779002121 ArsC family; Region: ArsC; pfam03960 266779002122 catalytic residues [active] 266779002123 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 266779002124 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266779002125 active site 266779002126 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779002127 putative DNA binding site [nucleotide binding]; other site 266779002128 putative Zn2+ binding site [ion binding]; other site 266779002129 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 266779002130 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 266779002131 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 266779002132 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 266779002133 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 266779002134 substrate binding pocket [chemical binding]; other site 266779002135 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 266779002136 B12 binding site [chemical binding]; other site 266779002137 cobalt ligand [ion binding]; other site 266779002138 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 266779002139 Domain of unknown function (DUF892); Region: DUF892; pfam05974 266779002140 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 266779002141 nucleobase-cation-symport-1 (NCS1) transporter Mhp1-like; solute-binding domain; Region: SLC-NCS1sbd_Mhp1-like; cd11483 266779002142 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 266779002143 Na binding site [ion binding]; other site 266779002144 substrate binding site [chemical binding]; other site 266779002145 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266779002146 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779002147 DNA-binding site [nucleotide binding]; DNA binding site 266779002148 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266779002149 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 266779002150 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 266779002151 Na binding site [ion binding]; other site 266779002152 putative substrate binding site [chemical binding]; other site 266779002153 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 266779002154 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 266779002155 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 266779002156 FAD binding pocket [chemical binding]; other site 266779002157 FAD binding motif [chemical binding]; other site 266779002158 phosphate binding motif [ion binding]; other site 266779002159 NAD binding pocket [chemical binding]; other site 266779002160 muropeptide transporter; Validated; Region: ampG; cl17669 266779002161 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 266779002162 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266779002163 N-terminal plug; other site 266779002164 ligand-binding site [chemical binding]; other site 266779002165 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266779002166 HAMP domain; Region: HAMP; pfam00672 266779002167 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266779002168 dimerization interface [polypeptide binding]; other site 266779002169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779002170 dimer interface [polypeptide binding]; other site 266779002171 phosphorylation site [posttranslational modification] 266779002172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779002173 ATP binding site [chemical binding]; other site 266779002174 Mg2+ binding site [ion binding]; other site 266779002175 G-X-G motif; other site 266779002176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779002177 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266779002178 active site 266779002179 phosphorylation site [posttranslational modification] 266779002180 intermolecular recognition site; other site 266779002181 dimerization interface [polypeptide binding]; other site 266779002182 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266779002183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779002184 active site 266779002185 phosphorylation site [posttranslational modification] 266779002186 intermolecular recognition site; other site 266779002187 dimerization interface [polypeptide binding]; other site 266779002188 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266779002189 DNA binding residues [nucleotide binding] 266779002190 dimerization interface [polypeptide binding]; other site 266779002191 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266779002192 Amidase; Region: Amidase; cl11426 266779002193 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 266779002194 DctM-like transporters; Region: DctM; pfam06808 266779002195 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 266779002196 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266779002197 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266779002198 FAD binding domain; Region: FAD_binding_4; pfam01565 266779002199 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 266779002200 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266779002201 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266779002202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779002203 ATP binding site [chemical binding]; other site 266779002204 Mg2+ binding site [ion binding]; other site 266779002205 G-X-G motif; other site 266779002206 mercuric reductase; Validated; Region: PRK06370 266779002207 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266779002208 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266779002209 Uncharacterized conserved protein [Function unknown]; Region: COG0398 266779002210 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 266779002211 Predicted membrane protein [Function unknown]; Region: COG2259 266779002212 fumarate hydratase; Reviewed; Region: fumC; PRK00485 266779002213 Class II fumarases; Region: Fumarase_classII; cd01362 266779002214 active site 266779002215 tetramer interface [polypeptide binding]; other site 266779002216 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266779002217 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266779002218 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266779002219 ring oligomerisation interface [polypeptide binding]; other site 266779002220 ATP/Mg binding site [chemical binding]; other site 266779002221 stacking interactions; other site 266779002222 hinge regions; other site 266779002223 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266779002224 oligomerisation interface [polypeptide binding]; other site 266779002225 mobile loop; other site 266779002226 roof hairpin; other site 266779002227 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 266779002228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266779002229 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266779002230 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 266779002231 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266779002232 Cysteine-rich domain; Region: CCG; pfam02754 266779002233 Cysteine-rich domain; Region: CCG; pfam02754 266779002234 Predicted membrane protein [Function unknown]; Region: COG3671 266779002235 FAD binding domain; Region: FAD_binding_4; pfam01565 266779002236 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 266779002237 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 266779002238 FAD binding domain; Region: FAD_binding_4; pfam01565 266779002239 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4949 266779002240 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 266779002241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779002242 DNA-binding site [nucleotide binding]; DNA binding site 266779002243 FCD domain; Region: FCD; pfam07729 266779002244 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 266779002245 Cysteine-rich domain; Region: CCG; pfam02754 266779002246 Cysteine-rich domain; Region: CCG; pfam02754 266779002247 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 266779002248 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 266779002249 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266779002250 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 266779002251 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 266779002252 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266779002253 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 266779002254 active site 266779002255 metal binding site [ion binding]; metal-binding site 266779002256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 266779002257 RNA methyltransferase, RsmE family; Region: TIGR00046 266779002258 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 266779002259 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 266779002260 ribonuclease P; Reviewed; Region: rnpA; PRK01313 266779002261 membrane protein insertase; Provisional; Region: PRK01318 266779002262 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 266779002263 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 266779002264 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 266779002265 trimer interface [polypeptide binding]; other site 266779002266 active site 266779002267 substrate binding site [chemical binding]; other site 266779002268 CoA binding site [chemical binding]; other site 266779002269 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 266779002270 G1 box; other site 266779002271 GTP/Mg2+ binding site [chemical binding]; other site 266779002272 Switch I region; other site 266779002273 G2 box; other site 266779002274 G3 box; other site 266779002275 Switch II region; other site 266779002276 G4 box; other site 266779002277 G5 box; other site 266779002278 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 266779002279 SelR domain; Region: SelR; pfam01641 266779002280 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 266779002281 homohexameric interface [polypeptide binding]; other site 266779002282 nucleotide binding site [chemical binding]; other site 266779002283 N-acetyl-L-glutamate binding site [chemical binding]; other site 266779002284 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266779002285 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266779002286 metal binding site [ion binding]; metal-binding site 266779002287 active site 266779002288 I-site; other site 266779002289 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 266779002290 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 266779002291 Protein of unknown function (DUF461); Region: DUF461; pfam04314 266779002292 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 266779002293 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 266779002294 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 266779002295 trimer interface [polypeptide binding]; other site 266779002296 active site 266779002297 substrate binding site [chemical binding]; other site 266779002298 CoA binding site [chemical binding]; other site 266779002299 Protein of unknown function (DUF805); Region: DUF805; pfam05656 266779002300 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 266779002301 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 266779002302 metal binding site [ion binding]; metal-binding site 266779002303 dimer interface [polypeptide binding]; other site 266779002304 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 266779002305 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 266779002306 dimerization interface 3.5A [polypeptide binding]; other site 266779002307 active site 266779002308 Predicted acetyltransferase [General function prediction only]; Region: COG3153 266779002309 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 266779002310 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 266779002311 putative active site [active] 266779002312 substrate binding site [chemical binding]; other site 266779002313 putative cosubstrate binding site; other site 266779002314 catalytic site [active] 266779002315 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 266779002316 substrate binding site [chemical binding]; other site 266779002317 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 266779002318 active site 266779002319 catalytic residues [active] 266779002320 metal binding site [ion binding]; metal-binding site 266779002321 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266779002322 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266779002323 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 266779002324 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 266779002325 active site 266779002326 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266779002327 substrate binding site [chemical binding]; other site 266779002328 dimer interface [polypeptide binding]; other site 266779002329 catalytic residues [active] 266779002330 Uncharacterized conserved protein [Function unknown]; Region: COG5476 266779002331 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 266779002332 MlrC C-terminus; Region: MlrC_C; pfam07171 266779002333 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266779002334 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266779002335 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266779002336 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266779002337 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 266779002338 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266779002339 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779002340 Walker A/P-loop; other site 266779002341 ATP binding site [chemical binding]; other site 266779002342 Q-loop/lid; other site 266779002343 ABC transporter signature motif; other site 266779002344 Walker B; other site 266779002345 D-loop; other site 266779002346 H-loop/switch region; other site 266779002347 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779002348 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266779002349 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779002350 Walker A/P-loop; other site 266779002351 ATP binding site [chemical binding]; other site 266779002352 Q-loop/lid; other site 266779002353 ABC transporter signature motif; other site 266779002354 Walker B; other site 266779002355 D-loop; other site 266779002356 H-loop/switch region; other site 266779002357 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266779002358 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266779002359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779002360 dimer interface [polypeptide binding]; other site 266779002361 conserved gate region; other site 266779002362 putative PBP binding loops; other site 266779002363 ABC-ATPase subunit interface; other site 266779002364 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779002365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779002366 dimer interface [polypeptide binding]; other site 266779002367 conserved gate region; other site 266779002368 putative PBP binding loops; other site 266779002369 ABC-ATPase subunit interface; other site 266779002370 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266779002371 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 266779002372 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779002373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779002374 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266779002375 dimerization interface [polypeptide binding]; other site 266779002376 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 266779002377 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 266779002378 active site residue [active] 266779002379 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 266779002380 active site residue [active] 266779002381 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266779002382 FAD binding domain; Region: FAD_binding_4; pfam01565 266779002383 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266779002384 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 266779002385 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266779002386 Beta-lactamase; Region: Beta-lactamase; cl17358 266779002387 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266779002388 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266779002389 Bacterial transcriptional regulator; Region: IclR; pfam01614 266779002390 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_15; cd12180 266779002391 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266779002392 putative ligand binding site [chemical binding]; other site 266779002393 putative NAD binding site [chemical binding]; other site 266779002394 catalytic site [active] 266779002395 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266779002396 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266779002397 classical (c) SDRs; Region: SDR_c; cd05233 266779002398 NAD(P) binding site [chemical binding]; other site 266779002399 active site 266779002400 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 266779002401 NIPSNAP; Region: NIPSNAP; pfam07978 266779002402 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266779002403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 266779002404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266779002405 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 266779002406 RmuC family; Region: RmuC; pfam02646 266779002407 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 266779002408 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 266779002409 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 266779002410 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 266779002411 motif 1; other site 266779002412 dimer interface [polypeptide binding]; other site 266779002413 active site 266779002414 motif 2; other site 266779002415 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 266779002416 active site 266779002417 motif 3; other site 266779002418 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 266779002419 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 266779002420 dimer interface [polypeptide binding]; other site 266779002421 motif 1; other site 266779002422 active site 266779002423 motif 2; other site 266779002424 motif 3; other site 266779002425 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 266779002426 anticodon binding site; other site 266779002427 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 266779002428 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 266779002429 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 266779002430 motif II; other site 266779002431 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 266779002432 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 266779002433 active site 266779002434 Riboflavin kinase; Region: Flavokinase; smart00904 266779002435 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 266779002436 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266779002437 active site 266779002438 HIGH motif; other site 266779002439 nucleotide binding site [chemical binding]; other site 266779002440 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 266779002441 active site 266779002442 KMSKS motif; other site 266779002443 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 266779002444 tRNA binding surface [nucleotide binding]; other site 266779002445 anticodon binding site; other site 266779002446 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266779002447 nucleoside/Zn binding site; other site 266779002448 dimer interface [polypeptide binding]; other site 266779002449 catalytic motif [active] 266779002450 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 266779002451 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266779002452 RNA binding surface [nucleotide binding]; other site 266779002453 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 266779002454 active site 266779002455 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 266779002456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779002457 S-adenosylmethionine binding site [chemical binding]; other site 266779002458 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266779002459 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 266779002460 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266779002461 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266779002462 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 266779002463 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266779002464 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266779002465 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 266779002466 nucleophile elbow; other site 266779002467 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 266779002468 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 266779002469 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 266779002470 TrkA-N domain; Region: TrkA_N; pfam02254 266779002471 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 266779002472 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 266779002473 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 266779002474 active site 266779002475 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 266779002476 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 266779002477 putative acyl-acceptor binding pocket; other site 266779002478 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 266779002479 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 266779002480 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266779002481 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 266779002482 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 266779002483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 266779002484 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 266779002485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779002486 ATP binding site [chemical binding]; other site 266779002487 Mg2+ binding site [ion binding]; other site 266779002488 G-X-G motif; other site 266779002489 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 266779002490 ATP binding site [chemical binding]; other site 266779002491 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 266779002492 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 266779002493 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 266779002494 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 266779002495 substrate-cofactor binding pocket; other site 266779002496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779002497 catalytic residue [active] 266779002498 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 266779002499 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266779002500 NAD(P) binding site [chemical binding]; other site 266779002501 Putative phosphatase (DUF442); Region: DUF442; cl17385 266779002502 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266779002503 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 266779002504 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266779002505 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266779002506 active site 266779002507 catalytic tetrad [active] 266779002508 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266779002509 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266779002510 Metal-binding active site; metal-binding site 266779002511 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 266779002512 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266779002513 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266779002514 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266779002515 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 266779002516 active site 266779002517 catalytic residues [active] 266779002518 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 266779002519 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 266779002520 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 266779002521 putative active site [active] 266779002522 putative substrate binding site [chemical binding]; other site 266779002523 putative cosubstrate binding site; other site 266779002524 catalytic site [active] 266779002525 Root hair defective 3 GTP-binding protein (RHD3); Region: RHD3; pfam05879 266779002526 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 266779002527 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 266779002528 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 266779002529 Substrate binding site; other site 266779002530 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 266779002531 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 266779002532 OsmC-like protein; Region: OsmC; pfam02566 266779002533 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266779002534 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 266779002535 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779002536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779002537 dimer interface [polypeptide binding]; other site 266779002538 conserved gate region; other site 266779002539 putative PBP binding loops; other site 266779002540 ABC-ATPase subunit interface; other site 266779002541 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266779002542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779002543 ABC-ATPase subunit interface; other site 266779002544 putative PBP binding loops; other site 266779002545 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266779002546 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779002547 Walker A/P-loop; other site 266779002548 ATP binding site [chemical binding]; other site 266779002549 Q-loop/lid; other site 266779002550 ABC transporter signature motif; other site 266779002551 Walker B; other site 266779002552 D-loop; other site 266779002553 H-loop/switch region; other site 266779002554 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779002555 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266779002556 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779002557 Walker A/P-loop; other site 266779002558 ATP binding site [chemical binding]; other site 266779002559 Q-loop/lid; other site 266779002560 ABC transporter signature motif; other site 266779002561 Walker B; other site 266779002562 D-loop; other site 266779002563 H-loop/switch region; other site 266779002564 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266779002565 16S rRNA methyltransferase B; Provisional; Region: PRK14901 266779002566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779002567 S-adenosylmethionine binding site [chemical binding]; other site 266779002568 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 266779002569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779002570 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 266779002571 dimerization interface [polypeptide binding]; other site 266779002572 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 266779002573 amphipathic channel; other site 266779002574 Asn-Pro-Ala signature motifs; other site 266779002575 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 266779002576 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 266779002577 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 266779002578 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 266779002579 active site 266779002580 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 266779002581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779002582 putative substrate translocation pore; other site 266779002583 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 266779002584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779002585 S-adenosylmethionine binding site [chemical binding]; other site 266779002586 exopolyphosphatase; Region: exo_poly_only; TIGR03706 266779002587 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 266779002588 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266779002589 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266779002590 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266779002591 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 266779002592 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266779002593 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266779002594 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266779002595 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266779002596 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266779002597 Walker A/P-loop; other site 266779002598 ATP binding site [chemical binding]; other site 266779002599 Q-loop/lid; other site 266779002600 ABC transporter signature motif; other site 266779002601 Walker B; other site 266779002602 D-loop; other site 266779002603 H-loop/switch region; other site 266779002604 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266779002605 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266779002606 Walker A/P-loop; other site 266779002607 ATP binding site [chemical binding]; other site 266779002608 Q-loop/lid; other site 266779002609 ABC transporter signature motif; other site 266779002610 Walker B; other site 266779002611 D-loop; other site 266779002612 H-loop/switch region; other site 266779002613 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266779002614 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266779002615 TM-ABC transporter signature motif; other site 266779002616 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266779002617 TM-ABC transporter signature motif; other site 266779002618 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266779002619 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266779002620 Putative cyclase; Region: Cyclase; pfam04199 266779002621 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266779002622 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266779002623 substrate binding site [chemical binding]; other site 266779002624 oxyanion hole (OAH) forming residues; other site 266779002625 trimer interface [polypeptide binding]; other site 266779002626 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 266779002627 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266779002628 Predicted oxidoreductase [General function prediction only]; Region: COG3573 266779002629 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266779002630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266779002631 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 266779002632 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 266779002633 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 266779002634 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 266779002635 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266779002636 Methyltransferase domain; Region: Methyltransf_24; pfam13578 266779002637 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 266779002638 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 266779002639 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 266779002640 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 266779002641 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266779002642 active site 266779002643 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 266779002644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779002645 Walker A/P-loop; other site 266779002646 ATP binding site [chemical binding]; other site 266779002647 Q-loop/lid; other site 266779002648 ABC transporter signature motif; other site 266779002649 Walker B; other site 266779002650 D-loop; other site 266779002651 H-loop/switch region; other site 266779002652 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 266779002653 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 266779002654 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266779002655 CoenzymeA binding site [chemical binding]; other site 266779002656 subunit interaction site [polypeptide binding]; other site 266779002657 PHB binding site; other site 266779002658 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 266779002659 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 266779002660 GMP synthase; Reviewed; Region: guaA; PRK00074 266779002661 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 266779002662 AMP/PPi binding site [chemical binding]; other site 266779002663 candidate oxyanion hole; other site 266779002664 catalytic triad [active] 266779002665 potential glutamine specificity residues [chemical binding]; other site 266779002666 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 266779002667 ATP Binding subdomain [chemical binding]; other site 266779002668 Ligand Binding sites [chemical binding]; other site 266779002669 Dimerization subdomain; other site 266779002670 integrase; Provisional; Region: PRK09692 266779002671 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266779002672 active site 266779002673 Int/Topo IB signature motif; other site 266779002674 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 266779002675 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779002676 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779002677 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266779002678 dimerization interface [polypeptide binding]; other site 266779002679 substrate binding pocket [chemical binding]; other site 266779002680 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 266779002681 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 266779002682 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 266779002683 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266779002684 VirB7 interaction site; other site 266779002685 conjugal transfer protein TrbF; Provisional; Region: PRK13872 266779002686 conjugal transfer protein TrbL; Provisional; Region: PRK13875 266779002687 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 266779002688 conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360 266779002689 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 266779002690 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 266779002691 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266779002692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779002693 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266779002694 Walker A motif; other site 266779002695 Walker A/P-loop; other site 266779002696 ATP binding site [chemical binding]; other site 266779002697 ATP binding site [chemical binding]; other site 266779002698 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 266779002699 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 266779002700 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 266779002701 Type II/IV secretion system protein; Region: T2SE; pfam00437 266779002702 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266779002703 Walker A motif; other site 266779002704 ATP binding site [chemical binding]; other site 266779002705 Walker B motif; other site 266779002706 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266779002707 non-specific DNA binding site [nucleotide binding]; other site 266779002708 salt bridge; other site 266779002709 sequence-specific DNA binding site [nucleotide binding]; other site 266779002710 HipA N-terminal domain; Region: Couple_hipA; pfam13657 266779002711 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 266779002712 HipA-like N-terminal domain; Region: HipA_N; pfam07805 266779002713 HipA-like C-terminal domain; Region: HipA_C; pfam07804 266779002714 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 266779002715 active site 266779002716 catalytic triad [active] 266779002717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779002718 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266779002719 Walker A motif; other site 266779002720 ATP binding site [chemical binding]; other site 266779002721 Walker B motif; other site 266779002722 arginine finger; other site 266779002723 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 266779002724 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 266779002725 Walker A motif; other site 266779002726 ATP binding site [chemical binding]; other site 266779002727 Walker B motif; other site 266779002728 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 266779002729 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 266779002730 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266779002731 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266779002732 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266779002733 catalytic residue [active] 266779002734 Protein of unknown function (DUF736); Region: DUF736; pfam05284 266779002735 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 266779002736 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 266779002737 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 266779002738 ParA-like protein; Provisional; Region: PHA02518 266779002739 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266779002740 P-loop; other site 266779002741 Magnesium ion binding site [ion binding]; other site 266779002742 Replication initiator protein A; Region: RPA; pfam10134 266779002743 Helix-turn-helix domain; Region: HTH_17; pfam12728 266779002744 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 266779002745 Uncharacterized conserved protein [Function unknown]; Region: COG5489 266779002746 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 266779002747 Toprim domain; Region: Toprim_3; pfam13362 266779002748 Methyltransferase domain; Region: Methyltransf_26; pfam13659 266779002749 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 266779002750 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266779002751 Helicase_C-like; Region: Helicase_C_4; pfam13871 266779002752 ParB-like nuclease domain; Region: ParBc; pfam02195 266779002753 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 266779002754 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 266779002755 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 266779002756 AAA domain; Region: AAA_14; pfam13173 266779002757 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 266779002758 putative active site [active] 266779002759 catalytic site [active] 266779002760 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 266779002761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266779002762 ATP binding site [chemical binding]; other site 266779002763 putative Mg++ binding site [ion binding]; other site 266779002764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266779002765 nucleotide binding region [chemical binding]; other site 266779002766 ATP-binding site [chemical binding]; other site 266779002767 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 266779002768 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 266779002769 DNA methylase; Region: N6_N4_Mtase; cl17433 266779002770 DNA methylase; Region: N6_N4_Mtase; pfam01555 266779002771 DNA methylase; Region: N6_N4_Mtase; cl17433 266779002772 Restriction endonuclease [Defense mechanisms]; Region: COG3587 266779002773 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 266779002774 ATP binding site [chemical binding]; other site 266779002775 putative Mg++ binding site [ion binding]; other site 266779002776 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 266779002777 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 266779002778 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 266779002779 active site 266779002780 metal binding site [ion binding]; metal-binding site 266779002781 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 266779002782 Part of AAA domain; Region: AAA_19; pfam13245 266779002783 Family description; Region: UvrD_C_2; pfam13538 266779002784 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 266779002785 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 266779002786 active site 266779002787 nucleophile elbow; other site 266779002788 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 266779002789 active site 266779002790 NTP binding site [chemical binding]; other site 266779002791 metal binding triad [ion binding]; metal-binding site 266779002792 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266779002793 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266779002794 non-specific DNA binding site [nucleotide binding]; other site 266779002795 salt bridge; other site 266779002796 sequence-specific DNA binding site [nucleotide binding]; other site 266779002797 Domain of unknown function (DUF955); Region: DUF955; pfam06114 266779002798 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266779002799 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266779002800 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 266779002801 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 266779002802 putative homodimer interface [polypeptide binding]; other site 266779002803 putative homotetramer interface [polypeptide binding]; other site 266779002804 putative metal binding site [ion binding]; other site 266779002805 putative homodimer-homodimer interface [polypeptide binding]; other site 266779002806 putative allosteric switch controlling residues; other site 266779002807 High-affinity nickel-transport protein; Region: NicO; cl00964 266779002808 High-affinity nickel-transport protein; Region: NicO; cl00964 266779002809 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266779002810 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779002811 Walker A/P-loop; other site 266779002812 ATP binding site [chemical binding]; other site 266779002813 Q-loop/lid; other site 266779002814 ABC transporter signature motif; other site 266779002815 Walker B; other site 266779002816 D-loop; other site 266779002817 H-loop/switch region; other site 266779002818 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779002819 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779002820 Walker A/P-loop; other site 266779002821 ATP binding site [chemical binding]; other site 266779002822 Q-loop/lid; other site 266779002823 ABC transporter signature motif; other site 266779002824 Walker B; other site 266779002825 D-loop; other site 266779002826 H-loop/switch region; other site 266779002827 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779002828 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266779002829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779002830 dimer interface [polypeptide binding]; other site 266779002831 conserved gate region; other site 266779002832 putative PBP binding loops; other site 266779002833 ABC-ATPase subunit interface; other site 266779002834 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779002835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779002836 dimer interface [polypeptide binding]; other site 266779002837 conserved gate region; other site 266779002838 putative PBP binding loops; other site 266779002839 ABC-ATPase subunit interface; other site 266779002840 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266779002841 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 266779002842 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 266779002843 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266779002844 active sites [active] 266779002845 tetramer interface [polypeptide binding]; other site 266779002846 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 266779002847 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266779002848 Coenzyme A binding pocket [chemical binding]; other site 266779002849 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266779002850 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 266779002851 NAD(P) binding site [chemical binding]; other site 266779002852 catalytic residues [active] 266779002853 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266779002854 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266779002855 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266779002856 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779002857 DNA-binding site [nucleotide binding]; DNA binding site 266779002858 FCD domain; Region: FCD; pfam07729 266779002859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266779002860 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 266779002861 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 266779002862 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 266779002863 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 266779002864 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 266779002865 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266779002866 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266779002867 conserved cys residue [active] 266779002868 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779002869 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779002870 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266779002871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779002872 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266779002873 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266779002874 active site 266779002875 catalytic tetrad [active] 266779002876 Uncharacterized conserved protein [Function unknown]; Region: COG1262 266779002877 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 266779002878 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266779002879 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266779002880 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779002881 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779002882 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779002883 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266779002884 dimerization interface [polypeptide binding]; other site 266779002885 substrate binding pocket [chemical binding]; other site 266779002886 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 266779002887 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266779002888 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266779002889 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266779002890 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266779002891 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 266779002892 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266779002893 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266779002894 catalytic loop [active] 266779002895 iron binding site [ion binding]; other site 266779002896 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266779002897 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 266779002898 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 266779002899 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 266779002900 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 266779002901 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 266779002902 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 266779002903 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 266779002904 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 266779002905 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 266779002906 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 266779002907 Autotransporter beta-domain; Region: Autotransporter; smart00869 266779002908 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 266779002909 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 266779002910 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266779002911 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 266779002912 substrate binding pocket [chemical binding]; other site 266779002913 FAD binding site [chemical binding]; other site 266779002914 catalytic base [active] 266779002915 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266779002916 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266779002917 conserved cys residue [active] 266779002918 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779002919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779002920 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 266779002921 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266779002922 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 266779002923 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 266779002924 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 266779002925 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266779002926 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 266779002927 CHASE4 domain; Region: CHASE4; pfam05228 266779002928 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266779002929 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266779002930 metal binding site [ion binding]; metal-binding site 266779002931 active site 266779002932 I-site; other site 266779002933 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266779002934 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266779002935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779002936 active site 266779002937 phosphorylation site [posttranslational modification] 266779002938 intermolecular recognition site; other site 266779002939 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266779002940 DNA binding residues [nucleotide binding] 266779002941 dimerization interface [polypeptide binding]; other site 266779002942 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 266779002943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779002944 S-adenosylmethionine binding site [chemical binding]; other site 266779002945 CheW-like domain; Region: CheW; pfam01584 266779002946 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266779002947 dimerization interface [polypeptide binding]; other site 266779002948 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266779002949 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266779002950 dimer interface [polypeptide binding]; other site 266779002951 putative CheW interface [polypeptide binding]; other site 266779002952 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266779002953 putative binding surface; other site 266779002954 active site 266779002955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779002956 ATP binding site [chemical binding]; other site 266779002957 Mg2+ binding site [ion binding]; other site 266779002958 G-X-G motif; other site 266779002959 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 266779002960 Response regulator receiver domain; Region: Response_reg; pfam00072 266779002961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779002962 active site 266779002963 phosphorylation site [posttranslational modification] 266779002964 intermolecular recognition site; other site 266779002965 dimerization interface [polypeptide binding]; other site 266779002966 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 266779002967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779002968 active site 266779002969 phosphorylation site [posttranslational modification] 266779002970 intermolecular recognition site; other site 266779002971 CheB methylesterase; Region: CheB_methylest; pfam01339 266779002972 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 266779002973 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266779002974 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 266779002975 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266779002976 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 266779002977 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266779002978 ATP binding site [chemical binding]; other site 266779002979 Walker A motif; other site 266779002980 hexamer interface [polypeptide binding]; other site 266779002981 Walker B motif; other site 266779002982 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 266779002983 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266779002984 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266779002985 TadE-like protein; Region: TadE; pfam07811 266779002986 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 266779002987 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 266779002988 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 266779002989 TadE-like protein; Region: TadE; pfam07811 266779002990 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 266779002991 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 266779002992 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 266779002993 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 266779002994 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266779002995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266779002996 TPR motif; other site 266779002997 binding surface 266779002998 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266779002999 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 266779003000 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266779003001 BON domain; Region: BON; pfam04972 266779003002 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266779003003 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 266779003004 active site 266779003005 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 266779003006 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 266779003007 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266779003008 HlyD family secretion protein; Region: HlyD_3; pfam13437 266779003009 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 266779003010 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266779003011 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 266779003012 Walker A/P-loop; other site 266779003013 ATP binding site [chemical binding]; other site 266779003014 Q-loop/lid; other site 266779003015 ABC transporter signature motif; other site 266779003016 Walker B; other site 266779003017 D-loop; other site 266779003018 H-loop/switch region; other site 266779003019 PAS fold; Region: PAS_4; pfam08448 266779003020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266779003021 putative active site [active] 266779003022 heme pocket [chemical binding]; other site 266779003023 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266779003024 metal binding site [ion binding]; metal-binding site 266779003025 active site 266779003026 I-site; other site 266779003027 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266779003028 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266779003029 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 266779003030 putative active site [active] 266779003031 heme pocket [chemical binding]; other site 266779003032 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266779003033 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 266779003034 putative active site [active] 266779003035 heme pocket [chemical binding]; other site 266779003036 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266779003037 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 266779003038 putative active site [active] 266779003039 heme pocket [chemical binding]; other site 266779003040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266779003041 putative active site [active] 266779003042 heme pocket [chemical binding]; other site 266779003043 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266779003044 HWE histidine kinase; Region: HWE_HK; pfam07536 266779003045 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266779003046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779003047 active site 266779003048 phosphorylation site [posttranslational modification] 266779003049 intermolecular recognition site; other site 266779003050 dimerization interface [polypeptide binding]; other site 266779003051 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266779003052 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 266779003053 conserved cys residue [active] 266779003054 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779003055 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266779003056 Methyltransferase domain; Region: Methyltransf_12; pfam08242 266779003057 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 266779003058 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 266779003059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266779003060 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266779003061 Coenzyme A binding pocket [chemical binding]; other site 266779003062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266779003063 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 266779003064 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 266779003065 dimer interface [polypeptide binding]; other site 266779003066 active site 266779003067 heme binding site [chemical binding]; other site 266779003068 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 266779003069 Uncharacterized conserved protein [Function unknown]; Region: COG5649 266779003070 Uncharacterized conserved protein [Function unknown]; Region: COG5649 266779003071 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266779003072 putative hydrophobic ligand binding site [chemical binding]; other site 266779003073 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779003074 dimerization interface [polypeptide binding]; other site 266779003075 putative DNA binding site [nucleotide binding]; other site 266779003076 putative Zn2+ binding site [ion binding]; other site 266779003077 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266779003078 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266779003079 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266779003080 Serine hydrolase (FSH1); Region: FSH1; pfam03959 266779003081 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 266779003082 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 266779003083 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 266779003084 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 266779003085 active site 266779003086 TIGR02588 family protein; Region: TIGR02588 266779003087 Putative integral membrane protein (DUF2391); Region: DUF2391; pfam09622 266779003088 RES domain; Region: RES; smart00953 266779003089 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 266779003090 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 266779003091 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 266779003092 Imelysin; Region: Peptidase_M75; cl09159 266779003093 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 266779003094 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 266779003095 Imelysin; Region: Peptidase_M75; cl09159 266779003096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 266779003097 PGAP1-like protein; Region: PGAP1; pfam07819 266779003098 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266779003099 nudix motif; other site 266779003100 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266779003101 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266779003102 active site 266779003103 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266779003104 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266779003105 active site 266779003106 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 266779003107 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 266779003108 active site 266779003109 catalytic residues [active] 266779003110 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 266779003111 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 266779003112 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 266779003113 O-Antigen ligase; Region: Wzy_C; cl04850 266779003114 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266779003115 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 266779003116 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266779003117 glycosyltransferase, MGT family; Region: MGT; TIGR01426 266779003118 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266779003119 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 266779003120 Ligand binding site; other site 266779003121 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266779003122 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 266779003123 active site 266779003124 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 266779003125 active site 266779003126 tetramer interface; other site 266779003127 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 266779003128 Chain length determinant protein; Region: Wzz; pfam02706 266779003129 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266779003130 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 266779003131 active site 266779003132 metal binding site [ion binding]; metal-binding site 266779003133 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 266779003134 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 266779003135 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 266779003136 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 266779003137 substrate binding site [chemical binding]; other site 266779003138 active site 266779003139 catalytic residues [active] 266779003140 heterodimer interface [polypeptide binding]; other site 266779003141 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 266779003142 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 266779003143 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 266779003144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779003145 catalytic residue [active] 266779003146 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 266779003147 active site 266779003148 Protein of unknown function DUF45; Region: DUF45; pfam01863 266779003149 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 266779003150 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266779003151 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 266779003152 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 266779003153 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 266779003154 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266779003155 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 266779003156 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 266779003157 23S rRNA binding site [nucleotide binding]; other site 266779003158 L21 binding site [polypeptide binding]; other site 266779003159 L13 binding site [polypeptide binding]; other site 266779003160 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 266779003161 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 266779003162 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 266779003163 dimer interface [polypeptide binding]; other site 266779003164 motif 1; other site 266779003165 active site 266779003166 motif 2; other site 266779003167 motif 3; other site 266779003168 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 266779003169 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 266779003170 putative tRNA-binding site [nucleotide binding]; other site 266779003171 B3/4 domain; Region: B3_4; pfam03483 266779003172 tRNA synthetase B5 domain; Region: B5; smart00874 266779003173 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 266779003174 dimer interface [polypeptide binding]; other site 266779003175 motif 1; other site 266779003176 motif 3; other site 266779003177 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 266779003178 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266779003179 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266779003180 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266779003181 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 266779003182 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 266779003183 nucleotide binding site [chemical binding]; other site 266779003184 NEF interaction site [polypeptide binding]; other site 266779003185 SBD interface [polypeptide binding]; other site 266779003186 chaperone protein DnaJ; Provisional; Region: PRK10767 266779003187 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266779003188 HSP70 interaction site [polypeptide binding]; other site 266779003189 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 266779003190 substrate binding site [polypeptide binding]; other site 266779003191 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 266779003192 Zn binding sites [ion binding]; other site 266779003193 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 266779003194 dimer interface [polypeptide binding]; other site 266779003195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779003196 S-adenosylmethionine binding site [chemical binding]; other site 266779003197 Predicted flavoprotein [General function prediction only]; Region: COG0431 266779003198 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266779003199 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 266779003200 active site 266779003201 dimer interface [polypeptide binding]; other site 266779003202 Uncharacterized conserved protein [Function unknown]; Region: COG5470 266779003203 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 266779003204 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 266779003205 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 266779003206 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 266779003207 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 266779003208 NodB motif; other site 266779003209 putative active site [active] 266779003210 putative catalytic site [active] 266779003211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 266779003212 GTP-binding protein Der; Reviewed; Region: PRK00093 266779003213 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 266779003214 G1 box; other site 266779003215 GTP/Mg2+ binding site [chemical binding]; other site 266779003216 Switch I region; other site 266779003217 G2 box; other site 266779003218 Switch II region; other site 266779003219 G3 box; other site 266779003220 G4 box; other site 266779003221 G5 box; other site 266779003222 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 266779003223 G1 box; other site 266779003224 GTP/Mg2+ binding site [chemical binding]; other site 266779003225 Switch I region; other site 266779003226 G2 box; other site 266779003227 G3 box; other site 266779003228 Switch II region; other site 266779003229 G4 box; other site 266779003230 G5 box; other site 266779003231 OsmC-like protein; Region: OsmC; pfam02566 266779003232 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 266779003233 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 266779003234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 266779003235 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 266779003236 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 266779003237 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 266779003238 F0F1 ATP synthase subunit B'; Validated; Region: PRK09174 266779003239 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 266779003240 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 266779003241 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 266779003242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266779003243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266779003244 NnrU protein; Region: NnrU; pfam07298 266779003245 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 266779003246 RNA/DNA hybrid binding site [nucleotide binding]; other site 266779003247 active site 266779003248 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 266779003249 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266779003250 FeS/SAM binding site; other site 266779003251 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 266779003252 MPT binding site; other site 266779003253 trimer interface [polypeptide binding]; other site 266779003254 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 266779003255 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 266779003256 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 266779003257 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 266779003258 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 266779003259 tandem repeat interface [polypeptide binding]; other site 266779003260 oligomer interface [polypeptide binding]; other site 266779003261 active site residues [active] 266779003262 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 266779003263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779003264 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 266779003265 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 266779003266 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 266779003267 substrate binding pocket [chemical binding]; other site 266779003268 chain length determination region; other site 266779003269 substrate-Mg2+ binding site; other site 266779003270 catalytic residues [active] 266779003271 aspartate-rich region 1; other site 266779003272 active site lid residues [active] 266779003273 aspartate-rich region 2; other site 266779003274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266779003275 binding surface 266779003276 TPR motif; other site 266779003277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266779003278 binding surface 266779003279 TPR motif; other site 266779003280 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 266779003281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266779003282 binding surface 266779003283 TPR motif; other site 266779003284 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266779003285 binding surface 266779003286 TPR motif; other site 266779003287 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266779003288 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 266779003289 dimer interface [polypeptide binding]; other site 266779003290 motif 1; other site 266779003291 active site 266779003292 motif 2; other site 266779003293 motif 3; other site 266779003294 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 266779003295 DALR anticodon binding domain; Region: DALR_1; pfam05746 266779003296 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 266779003297 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 266779003298 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266779003299 FAD binding domain; Region: FAD_binding_4; pfam01565 266779003300 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 266779003301 UbiA prenyltransferase family; Region: UbiA; pfam01040 266779003302 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 266779003303 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 266779003304 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 266779003305 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 266779003306 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 266779003307 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 266779003308 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 266779003309 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266779003310 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266779003311 active site 266779003312 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 266779003313 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 266779003314 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 266779003315 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 266779003316 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 266779003317 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266779003318 HSP70 interaction site [polypeptide binding]; other site 266779003319 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 266779003320 substrate binding site [polypeptide binding]; other site 266779003321 dimer interface [polypeptide binding]; other site 266779003322 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 266779003323 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 266779003324 NAD binding site [chemical binding]; other site 266779003325 homotetramer interface [polypeptide binding]; other site 266779003326 homodimer interface [polypeptide binding]; other site 266779003327 substrate binding site [chemical binding]; other site 266779003328 active site 266779003329 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266779003330 catalytic core [active] 266779003331 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 266779003332 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 266779003333 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 266779003334 Tetramer interface [polypeptide binding]; other site 266779003335 active site 266779003336 FMN-binding site [chemical binding]; other site 266779003337 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 266779003338 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 266779003339 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 266779003340 dimerization interface [polypeptide binding]; other site 266779003341 active site 266779003342 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266779003343 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 266779003344 putative active site [active] 266779003345 Zn binding site [ion binding]; other site 266779003346 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 266779003347 Pirin-related protein [General function prediction only]; Region: COG1741 266779003348 Pirin; Region: Pirin; pfam02678 266779003349 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 266779003350 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 266779003351 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 266779003352 TPP-binding site; other site 266779003353 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266779003354 PYR/PP interface [polypeptide binding]; other site 266779003355 dimer interface [polypeptide binding]; other site 266779003356 TPP binding site [chemical binding]; other site 266779003357 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266779003358 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 266779003359 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266779003360 RNA binding surface [nucleotide binding]; other site 266779003361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779003362 S-adenosylmethionine binding site [chemical binding]; other site 266779003363 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 266779003364 TRAM domain; Region: TRAM; pfam01938 266779003365 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266779003366 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266779003367 catalytic residue [active] 266779003368 protease TldD; Provisional; Region: tldD; PRK10735 266779003369 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 266779003370 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 266779003371 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 266779003372 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266779003373 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266779003374 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 266779003375 Subunit I/III interface [polypeptide binding]; other site 266779003376 D-pathway; other site 266779003377 Subunit I/VIIc interface [polypeptide binding]; other site 266779003378 Subunit I/IV interface [polypeptide binding]; other site 266779003379 Subunit I/II interface [polypeptide binding]; other site 266779003380 Low-spin heme (heme a) binding site [chemical binding]; other site 266779003381 Subunit I/VIIa interface [polypeptide binding]; other site 266779003382 Subunit I/VIa interface [polypeptide binding]; other site 266779003383 Dimer interface; other site 266779003384 Putative water exit pathway; other site 266779003385 Binuclear center (heme a3/CuB) [ion binding]; other site 266779003386 K-pathway; other site 266779003387 Subunit I/Vb interface [polypeptide binding]; other site 266779003388 Putative proton exit pathway; other site 266779003389 Subunit I/VIb interface; other site 266779003390 Subunit I/VIc interface [polypeptide binding]; other site 266779003391 Electron transfer pathway; other site 266779003392 Subunit I/VIIIb interface [polypeptide binding]; other site 266779003393 Subunit I/VIIb interface [polypeptide binding]; other site 266779003394 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 266779003395 UbiA prenyltransferase family; Region: UbiA; pfam01040 266779003396 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 266779003397 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 266779003398 Subunit III/VIIa interface [polypeptide binding]; other site 266779003399 Phospholipid binding site [chemical binding]; other site 266779003400 Subunit I/III interface [polypeptide binding]; other site 266779003401 Subunit III/VIb interface [polypeptide binding]; other site 266779003402 Subunit III/VIa interface; other site 266779003403 Subunit III/Vb interface [polypeptide binding]; other site 266779003404 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 266779003405 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 266779003406 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 266779003407 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 266779003408 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 266779003409 putative active site [active] 266779003410 putative substrate binding site [chemical binding]; other site 266779003411 ATP binding site [chemical binding]; other site 266779003412 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 266779003413 RNA/DNA hybrid binding site [nucleotide binding]; other site 266779003414 active site 266779003415 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 266779003416 catalytic triad [active] 266779003417 dimer interface [polypeptide binding]; other site 266779003418 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 266779003419 hypothetical protein; Validated; Region: PRK00228 266779003420 Uncharacterized conserved protein [Function unknown]; Region: COG3339 266779003421 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266779003422 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 266779003423 putative metal binding site [ion binding]; other site 266779003424 putative homodimer interface [polypeptide binding]; other site 266779003425 putative homotetramer interface [polypeptide binding]; other site 266779003426 putative homodimer-homodimer interface [polypeptide binding]; other site 266779003427 putative allosteric switch controlling residues; other site 266779003428 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 266779003429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266779003430 putative active site [active] 266779003431 PAS fold; Region: PAS_3; pfam08447 266779003432 heme pocket [chemical binding]; other site 266779003433 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266779003434 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266779003435 metal binding site [ion binding]; metal-binding site 266779003436 active site 266779003437 I-site; other site 266779003438 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266779003439 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266779003440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266779003441 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266779003442 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 266779003443 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266779003444 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 266779003445 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 266779003446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779003447 catalytic residue [active] 266779003448 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266779003449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266779003450 motif II; other site 266779003451 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 266779003452 DNA methylase; Region: N6_N4_Mtase; pfam01555 266779003453 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 266779003454 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 266779003455 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 266779003456 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266779003457 minor groove reading motif; other site 266779003458 helix-hairpin-helix signature motif; other site 266779003459 substrate binding pocket [chemical binding]; other site 266779003460 active site 266779003461 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 266779003462 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 266779003463 DNA binding and oxoG recognition site [nucleotide binding] 266779003464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389 266779003465 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 266779003466 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 266779003467 catalytic residues [active] 266779003468 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 266779003469 AAA domain; Region: AAA_23; pfam13476 266779003470 Walker A/P-loop; other site 266779003471 ATP binding site [chemical binding]; other site 266779003472 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 266779003473 ABC transporter signature motif; other site 266779003474 Walker B; other site 266779003475 D-loop; other site 266779003476 H-loop/switch region; other site 266779003477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779003478 AAA domain; Region: AAA_18; pfam13238 266779003479 Walker A motif; other site 266779003480 ATP binding site [chemical binding]; other site 266779003481 Walker B motif; other site 266779003482 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 266779003483 pyruvate phosphate dikinase; Provisional; Region: PRK09279 266779003484 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 266779003485 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 266779003486 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 266779003487 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 266779003488 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266779003489 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 266779003490 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 266779003491 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 266779003492 NAD binding site [chemical binding]; other site 266779003493 homodimer interface [polypeptide binding]; other site 266779003494 active site 266779003495 substrate binding site [chemical binding]; other site 266779003496 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266779003497 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 266779003498 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 266779003499 NAD(P) binding site [chemical binding]; other site 266779003500 homodimer interface [polypeptide binding]; other site 266779003501 substrate binding site [chemical binding]; other site 266779003502 active site 266779003503 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266779003504 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 266779003505 Sulfate transporter family; Region: Sulfate_transp; pfam00916 266779003506 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266779003507 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266779003508 Ligand Binding Site [chemical binding]; other site 266779003509 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266779003510 Ligand Binding Site [chemical binding]; other site 266779003511 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266779003512 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 266779003513 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 266779003514 dimer interface [polypeptide binding]; other site 266779003515 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 266779003516 active site 266779003517 Fe binding site [ion binding]; other site 266779003518 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266779003519 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266779003520 classical (c) SDRs; Region: SDR_c; cd05233 266779003521 NAD(P) binding site [chemical binding]; other site 266779003522 active site 266779003523 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266779003524 extended (e) SDRs; Region: SDR_e; cd08946 266779003525 NAD(P) binding site [chemical binding]; other site 266779003526 active site 266779003527 substrate binding site [chemical binding]; other site 266779003528 DctM-like transporters; Region: DctM; pfam06808 266779003529 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 266779003530 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 266779003531 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 266779003532 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 266779003533 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266779003534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779003535 DNA-binding site [nucleotide binding]; DNA binding site 266779003536 FCD domain; Region: FCD; pfam07729 266779003537 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 266779003538 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 266779003539 heme binding site [chemical binding]; other site 266779003540 substrate binding site [chemical binding]; other site 266779003541 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 266779003542 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 266779003543 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 266779003544 Walker A/P-loop; other site 266779003545 ATP binding site [chemical binding]; other site 266779003546 Q-loop/lid; other site 266779003547 ABC transporter signature motif; other site 266779003548 Walker B; other site 266779003549 D-loop; other site 266779003550 H-loop/switch region; other site 266779003551 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 266779003552 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 266779003553 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266779003554 HlyD family secretion protein; Region: HlyD_3; pfam13437 266779003555 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266779003556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779003557 ATP binding site [chemical binding]; other site 266779003558 Mg2+ binding site [ion binding]; other site 266779003559 G-X-G motif; other site 266779003560 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266779003561 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266779003562 DNA binding residues [nucleotide binding] 266779003563 dimerization interface [polypeptide binding]; other site 266779003564 Response regulator receiver domain; Region: Response_reg; pfam00072 266779003565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779003566 active site 266779003567 phosphorylation site [posttranslational modification] 266779003568 intermolecular recognition site; other site 266779003569 dimerization interface [polypeptide binding]; other site 266779003570 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779003571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779003572 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 266779003573 putative dimerization interface [polypeptide binding]; other site 266779003574 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 266779003575 Catalytic domain of bacterial PuuE allantoinases, Helicobacter pylori peptidoglycan deacetylase (HpPgdA), and similar proteins; Region: CE4_PuuE_HpPgdA_like; cd10916 266779003576 active site 266779003577 catalytic site [active] 266779003578 tetramer interface [polypeptide binding]; other site 266779003579 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266779003580 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 266779003581 DNA binding residues [nucleotide binding] 266779003582 dimerization interface [polypeptide binding]; other site 266779003583 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266779003584 PYR/PP interface [polypeptide binding]; other site 266779003585 dimer interface [polypeptide binding]; other site 266779003586 TPP binding site [chemical binding]; other site 266779003587 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266779003588 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 266779003589 TPP-binding site [chemical binding]; other site 266779003590 dimer interface [polypeptide binding]; other site 266779003591 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266779003592 PYR/PP interface [polypeptide binding]; other site 266779003593 dimer interface [polypeptide binding]; other site 266779003594 TPP binding site [chemical binding]; other site 266779003595 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 266779003596 TPP-binding site [chemical binding]; other site 266779003597 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266779003598 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 266779003599 NAD(P) binding site [chemical binding]; other site 266779003600 catalytic residues [active] 266779003601 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266779003602 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266779003603 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266779003604 substrate binding pocket [chemical binding]; other site 266779003605 membrane-bound complex binding site; other site 266779003606 hinge residues; other site 266779003607 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266779003608 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266779003609 Walker A/P-loop; other site 266779003610 ATP binding site [chemical binding]; other site 266779003611 Q-loop/lid; other site 266779003612 ABC transporter signature motif; other site 266779003613 Walker B; other site 266779003614 D-loop; other site 266779003615 H-loop/switch region; other site 266779003616 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266779003617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779003618 ABC-ATPase subunit interface; other site 266779003619 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266779003620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779003621 ABC-ATPase subunit interface; other site 266779003622 MarR family; Region: MarR_2; cl17246 266779003623 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266779003624 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 266779003625 FAD binding pocket [chemical binding]; other site 266779003626 FAD binding motif [chemical binding]; other site 266779003627 phosphate binding motif [ion binding]; other site 266779003628 NAD binding pocket [chemical binding]; other site 266779003629 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266779003630 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266779003631 FAD binding domain; Region: FAD_binding_3; pfam01494 266779003632 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266779003633 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266779003634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779003635 dimer interface [polypeptide binding]; other site 266779003636 conserved gate region; other site 266779003637 putative PBP binding loops; other site 266779003638 ABC-ATPase subunit interface; other site 266779003639 NMT1/THI5 like; Region: NMT1; pfam09084 266779003640 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 266779003641 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266779003642 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266779003643 Walker A/P-loop; other site 266779003644 ATP binding site [chemical binding]; other site 266779003645 Q-loop/lid; other site 266779003646 ABC transporter signature motif; other site 266779003647 Walker B; other site 266779003648 D-loop; other site 266779003649 H-loop/switch region; other site 266779003650 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266779003651 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266779003652 Bacterial transcriptional regulator; Region: IclR; pfam01614 266779003653 Cupin domain; Region: Cupin_2; pfam07883 266779003654 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266779003655 N-terminal, non-catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Rhodococcus rhodochrous K37, and similar proteins; Region: BphC5-RrK37_N_like; cd08362 266779003656 putative oligomer interface [polypeptide binding]; other site 266779003657 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 266779003658 C-terminal, catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacterium Rhodococcus rhodochrous K37 and similar proteins; Region: BphC5-RK37_C_like; cd07239 266779003659 putative active site [active] 266779003660 Mn binding site [ion binding]; other site 266779003661 putative oligomer interface [polypeptide binding]; other site 266779003662 short chain dehydrogenase; Provisional; Region: PRK07062 266779003663 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 266779003664 putative NAD(P) binding site [chemical binding]; other site 266779003665 putative active site [active] 266779003666 hypothetical protein; Provisional; Region: PRK07064 266779003667 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266779003668 PYR/PP interface [polypeptide binding]; other site 266779003669 dimer interface [polypeptide binding]; other site 266779003670 TPP binding site [chemical binding]; other site 266779003671 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266779003672 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266779003673 TPP-binding site [chemical binding]; other site 266779003674 L-aspartate dehydrogenase; Provisional; Region: PRK13303 266779003675 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 266779003676 Domain of unknown function DUF108; Region: DUF108; pfam01958 266779003677 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266779003678 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 266779003679 NAD(P) binding site [chemical binding]; other site 266779003680 catalytic residues [active] 266779003681 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266779003682 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 266779003683 Walker A/P-loop; other site 266779003684 ATP binding site [chemical binding]; other site 266779003685 Q-loop/lid; other site 266779003686 ABC transporter signature motif; other site 266779003687 Walker B; other site 266779003688 D-loop; other site 266779003689 H-loop/switch region; other site 266779003690 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 266779003691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779003692 dimer interface [polypeptide binding]; other site 266779003693 conserved gate region; other site 266779003694 putative PBP binding loops; other site 266779003695 ABC-ATPase subunit interface; other site 266779003696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779003697 dimer interface [polypeptide binding]; other site 266779003698 conserved gate region; other site 266779003699 putative PBP binding loops; other site 266779003700 ABC-ATPase subunit interface; other site 266779003701 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266779003702 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266779003703 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266779003704 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266779003705 active site 266779003706 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266779003707 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779003708 DNA-binding site [nucleotide binding]; DNA binding site 266779003709 FCD domain; Region: FCD; pfam07729 266779003710 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 266779003711 phosphomannomutase CpsG; Provisional; Region: PRK15414 266779003712 active site 266779003713 substrate binding site [chemical binding]; other site 266779003714 metal binding site [ion binding]; metal-binding site 266779003715 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 266779003716 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 266779003717 inhibitor-cofactor binding pocket; inhibition site 266779003718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779003719 catalytic residue [active] 266779003720 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 266779003721 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 266779003722 Active Sites [active] 266779003723 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 266779003724 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 266779003725 CysD dimerization site [polypeptide binding]; other site 266779003726 G1 box; other site 266779003727 putative GEF interaction site [polypeptide binding]; other site 266779003728 GTP/Mg2+ binding site [chemical binding]; other site 266779003729 Switch I region; other site 266779003730 G2 box; other site 266779003731 G3 box; other site 266779003732 Switch II region; other site 266779003733 G4 box; other site 266779003734 G5 box; other site 266779003735 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 266779003736 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 266779003737 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 266779003738 ligand-binding site [chemical binding]; other site 266779003739 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 266779003740 active site 266779003741 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 266779003742 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266779003743 putative substrate binding site [chemical binding]; other site 266779003744 putative ATP binding site [chemical binding]; other site 266779003745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779003746 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266779003747 dimerization interface [polypeptide binding]; other site 266779003748 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 266779003749 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 266779003750 putative ligand binding site [chemical binding]; other site 266779003751 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266779003752 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266779003753 Walker A/P-loop; other site 266779003754 ATP binding site [chemical binding]; other site 266779003755 Q-loop/lid; other site 266779003756 ABC transporter signature motif; other site 266779003757 Walker B; other site 266779003758 D-loop; other site 266779003759 H-loop/switch region; other site 266779003760 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266779003761 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266779003762 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266779003763 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266779003764 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266779003765 TM-ABC transporter signature motif; other site 266779003766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 266779003767 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266779003768 dihydroxy-acid dehydratase; Validated; Region: PRK06131 266779003769 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266779003770 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266779003771 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 266779003772 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 266779003773 dimer interface [polypeptide binding]; other site 266779003774 NADP binding site [chemical binding]; other site 266779003775 catalytic residues [active] 266779003776 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 266779003777 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 266779003778 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 266779003779 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 266779003780 active site 266779003781 intersubunit interface [polypeptide binding]; other site 266779003782 catalytic residue [active] 266779003783 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 266779003784 EF-hand domain pair; Region: EF_hand_5; pfam13499 266779003785 Ca2+ binding site [ion binding]; other site 266779003786 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266779003787 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266779003788 active site 266779003789 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266779003790 classical (c) SDRs; Region: SDR_c; cd05233 266779003791 NAD(P) binding site [chemical binding]; other site 266779003792 active site 266779003793 L-asparaginase II; Region: Asparaginase_II; pfam06089 266779003794 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 266779003795 putative addiction module antidote; Region: doc_partner; TIGR02609 266779003796 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266779003797 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266779003798 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 266779003799 Cl binding site [ion binding]; other site 266779003800 oligomer interface [polypeptide binding]; other site 266779003801 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 266779003802 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 266779003803 active site 266779003804 substrate binding site [chemical binding]; other site 266779003805 coenzyme B12 binding site [chemical binding]; other site 266779003806 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 266779003807 B12 binding site [chemical binding]; other site 266779003808 cobalt ligand [ion binding]; other site 266779003809 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 266779003810 heterodimer interface [polypeptide binding]; other site 266779003811 substrate interaction site [chemical binding]; other site 266779003812 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 266779003813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266779003814 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266779003815 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 266779003816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266779003817 motif II; other site 266779003818 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 266779003819 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 266779003820 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 266779003821 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 266779003822 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266779003823 methionine sulfoxide reductase B; Provisional; Region: PRK00222 266779003824 SelR domain; Region: SelR; pfam01641 266779003825 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 266779003826 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 266779003827 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266779003828 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 266779003829 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 266779003830 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12658 266779003831 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 266779003832 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266779003833 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 266779003834 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 266779003835 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 266779003836 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 266779003837 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 266779003838 DnaA box-binding interface [nucleotide binding]; other site 266779003839 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 266779003840 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266779003841 putative active site [active] 266779003842 heme pocket [chemical binding]; other site 266779003843 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266779003844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779003845 dimer interface [polypeptide binding]; other site 266779003846 phosphorylation site [posttranslational modification] 266779003847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779003848 ATP binding site [chemical binding]; other site 266779003849 Mg2+ binding site [ion binding]; other site 266779003850 G-X-G motif; other site 266779003851 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 266779003852 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266779003853 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266779003854 Uncharacterized conserved protein [Function unknown]; Region: COG5447 266779003855 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 266779003856 Predicted integral membrane protein [Function unknown]; Region: COG5436 266779003857 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 266779003858 Transglycosylase; Region: Transgly; pfam00912 266779003859 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 266779003860 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266779003861 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 266779003862 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 266779003863 Domain of unknown function (DUF955); Region: DUF955; pfam06114 266779003864 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266779003865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779003866 active site 266779003867 phosphorylation site [posttranslational modification] 266779003868 intermolecular recognition site; other site 266779003869 dimerization interface [polypeptide binding]; other site 266779003870 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266779003871 DNA binding site [nucleotide binding] 266779003872 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266779003873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779003874 ATP binding site [chemical binding]; other site 266779003875 Mg2+ binding site [ion binding]; other site 266779003876 G-X-G motif; other site 266779003877 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 266779003878 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 266779003879 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 266779003880 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266779003881 TPR motif; other site 266779003882 binding surface 266779003883 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 266779003884 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 266779003885 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 266779003886 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266779003887 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266779003888 protein binding site [polypeptide binding]; other site 266779003889 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266779003890 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266779003891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779003892 active site 266779003893 phosphorylation site [posttranslational modification] 266779003894 intermolecular recognition site; other site 266779003895 dimerization interface [polypeptide binding]; other site 266779003896 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266779003897 DNA binding site [nucleotide binding] 266779003898 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266779003899 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266779003900 dimerization interface [polypeptide binding]; other site 266779003901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779003902 dimer interface [polypeptide binding]; other site 266779003903 phosphorylation site [posttranslational modification] 266779003904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779003905 ATP binding site [chemical binding]; other site 266779003906 Mg2+ binding site [ion binding]; other site 266779003907 G-X-G motif; other site 266779003908 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 266779003909 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266779003910 metal binding triad; other site 266779003911 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 266779003912 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266779003913 metal binding triad; other site 266779003914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266779003915 PAS fold; Region: PAS_3; pfam08447 266779003916 putative active site [active] 266779003917 heme pocket [chemical binding]; other site 266779003918 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266779003919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779003920 dimer interface [polypeptide binding]; other site 266779003921 phosphorylation site [posttranslational modification] 266779003922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779003923 ATP binding site [chemical binding]; other site 266779003924 Mg2+ binding site [ion binding]; other site 266779003925 G-X-G motif; other site 266779003926 aminopeptidase N; Provisional; Region: pepN; PRK14015 266779003927 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 266779003928 active site 266779003929 Zn binding site [ion binding]; other site 266779003930 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266779003931 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266779003932 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266779003933 EamA-like transporter family; Region: EamA; pfam00892 266779003934 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266779003935 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 266779003936 Fe-S cluster binding site [ion binding]; other site 266779003937 active site 266779003938 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 266779003939 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266779003940 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 266779003941 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 266779003942 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 266779003943 active site 266779003944 catalytic triad [active] 266779003945 oxyanion hole [active] 266779003946 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266779003947 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266779003948 putative catalytic site [active] 266779003949 putative metal binding site [ion binding]; other site 266779003950 putative phosphate binding site [ion binding]; other site 266779003951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779003952 S-adenosylmethionine binding site [chemical binding]; other site 266779003953 AMP nucleosidase; Provisional; Region: PRK08292 266779003954 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 266779003955 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 266779003956 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266779003957 Sel1 repeat; Region: Sel1; cl02723 266779003958 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 266779003959 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266779003960 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266779003961 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266779003962 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266779003963 carboxyltransferase (CT) interaction site; other site 266779003964 biotinylation site [posttranslational modification]; other site 266779003965 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 266779003966 Protein of unknown function DUF262; Region: DUF262; pfam03235 266779003967 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266779003968 active site 266779003969 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 266779003970 putative ADP-ribose binding site [chemical binding]; other site 266779003971 putative active site [active] 266779003972 major curlin subunit; Provisional; Region: csgA; PRK10051 266779003973 Curlin associated repeat; Region: Curlin_rpt; pfam07012 266779003974 Curlin associated repeat; Region: Curlin_rpt; pfam07012 266779003975 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 266779003976 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 266779003977 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 266779003978 isovaleryl-CoA dehydrogenase; Region: PLN02519 266779003979 substrate binding site [chemical binding]; other site 266779003980 FAD binding site [chemical binding]; other site 266779003981 catalytic base [active] 266779003982 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 266779003983 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266779003984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779003985 homodimer interface [polypeptide binding]; other site 266779003986 catalytic residue [active] 266779003987 Predicted membrane protein [Function unknown]; Region: COG2259 266779003988 TIGR02594 family protein; Region: TIGR02594 266779003989 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 266779003990 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266779003991 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266779003992 catalytic residue [active] 266779003993 Porin subfamily; Region: Porin_2; pfam02530 266779003994 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266779003995 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266779003996 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266779003997 catalytic residue [active] 266779003998 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266779003999 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 266779004000 dimer interface [polypeptide binding]; other site 266779004001 active site 266779004002 catalytic residue [active] 266779004003 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 266779004004 SmpB-tmRNA interface; other site 266779004005 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 266779004006 Fe-S cluster binding site [ion binding]; other site 266779004007 DNA binding site [nucleotide binding] 266779004008 active site 266779004009 Uncharacterized conserved protein [Function unknown]; Region: COG1432 266779004010 LabA_like proteins; Region: LabA; cd10911 266779004011 putative metal binding site [ion binding]; other site 266779004012 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 266779004013 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 266779004014 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266779004015 Zn2+ binding site [ion binding]; other site 266779004016 Mg2+ binding site [ion binding]; other site 266779004017 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 266779004018 synthetase active site [active] 266779004019 NTP binding site [chemical binding]; other site 266779004020 metal binding site [ion binding]; metal-binding site 266779004021 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 266779004022 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 266779004023 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 266779004024 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 266779004025 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 266779004026 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266779004027 Catalytic site [active] 266779004028 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266779004029 ribonuclease III; Reviewed; Region: PRK12371 266779004030 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 266779004031 dimerization interface [polypeptide binding]; other site 266779004032 active site 266779004033 metal binding site [ion binding]; metal-binding site 266779004034 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 266779004035 dsRNA binding site [nucleotide binding]; other site 266779004036 GTPase Era; Reviewed; Region: era; PRK00089 266779004037 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 266779004038 G1 box; other site 266779004039 GTP/Mg2+ binding site [chemical binding]; other site 266779004040 Switch I region; other site 266779004041 G2 box; other site 266779004042 Switch II region; other site 266779004043 G3 box; other site 266779004044 G4 box; other site 266779004045 G5 box; other site 266779004046 KH domain; Region: KH_2; pfam07650 266779004047 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 266779004048 Recombination protein O N terminal; Region: RecO_N; pfam11967 266779004049 Recombination protein O C terminal; Region: RecO_C; pfam02565 266779004050 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 266779004051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779004052 putative substrate translocation pore; other site 266779004053 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 266779004054 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266779004055 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266779004056 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 266779004057 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266779004058 Coenzyme A binding pocket [chemical binding]; other site 266779004059 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 266779004060 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 266779004061 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 266779004062 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 266779004063 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 266779004064 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 266779004065 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266779004066 Protein of unknown function (DUF2385); Region: DUF2385; pfam09539 266779004067 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 266779004068 nudix motif; other site 266779004069 Uncharacterized conserved protein [Function unknown]; Region: COG2135 266779004070 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 266779004071 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 266779004072 active site 266779004073 HIGH motif; other site 266779004074 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 266779004075 KMSKS motif; other site 266779004076 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 266779004077 tRNA binding surface [nucleotide binding]; other site 266779004078 anticodon binding site; other site 266779004079 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 266779004080 putative active site [active] 266779004081 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 266779004082 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266779004083 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266779004084 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 266779004085 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 266779004086 active site 266779004087 catalytic residues [active] 266779004088 metal binding site [ion binding]; metal-binding site 266779004089 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 266779004090 Predicted permeases [General function prediction only]; Region: RarD; COG2962 266779004091 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 266779004092 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 266779004093 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 266779004094 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 266779004095 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779004096 dimerization interface [polypeptide binding]; other site 266779004097 putative DNA binding site [nucleotide binding]; other site 266779004098 putative Zn2+ binding site [ion binding]; other site 266779004099 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 266779004100 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266779004101 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 266779004102 Walker A/P-loop; other site 266779004103 ATP binding site [chemical binding]; other site 266779004104 Q-loop/lid; other site 266779004105 ABC transporter signature motif; other site 266779004106 Walker B; other site 266779004107 D-loop; other site 266779004108 H-loop/switch region; other site 266779004109 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266779004110 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266779004111 active site 266779004112 catalytic tetrad [active] 266779004113 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 266779004114 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 266779004115 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 266779004116 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 266779004117 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266779004118 classical (c) SDRs; Region: SDR_c; cd05233 266779004119 NAD(P) binding site [chemical binding]; other site 266779004120 active site 266779004121 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 266779004122 amidophosphoribosyltransferase; Provisional; Region: PRK09123 266779004123 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 266779004124 active site 266779004125 tetramer interface [polypeptide binding]; other site 266779004126 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266779004127 active site 266779004128 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 266779004129 Colicin V production protein; Region: Colicin_V; pfam02674 266779004130 DNA repair protein RadA; Provisional; Region: PRK11823 266779004131 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266779004132 Walker A motif; other site 266779004133 ATP binding site [chemical binding]; other site 266779004134 Walker B motif; other site 266779004135 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 266779004136 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 266779004137 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 266779004138 active site 266779004139 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266779004140 dimer interface [polypeptide binding]; other site 266779004141 substrate binding site [chemical binding]; other site 266779004142 catalytic residues [active] 266779004143 replicative DNA helicase; Provisional; Region: PRK09165 266779004144 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 266779004145 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 266779004146 Walker A motif; other site 266779004147 ATP binding site [chemical binding]; other site 266779004148 Walker B motif; other site 266779004149 DNA binding loops [nucleotide binding] 266779004150 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 266779004151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779004152 S-adenosylmethionine binding site [chemical binding]; other site 266779004153 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 266779004154 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 266779004155 putative active site [active] 266779004156 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 266779004157 DHH family; Region: DHH; pfam01368 266779004158 DHHA1 domain; Region: DHHA1; pfam02272 266779004159 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 266779004160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 266779004161 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266779004162 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266779004163 AP (apurinic/apyrimidinic) site pocket; other site 266779004164 DNA interaction; other site 266779004165 Metal-binding active site; metal-binding site 266779004166 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 266779004167 Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_pAtGDE_like; cd08565 266779004168 active site 266779004169 catalytic site [active] 266779004170 metal binding site [ion binding]; metal-binding site 266779004171 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266779004172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779004173 dimer interface [polypeptide binding]; other site 266779004174 conserved gate region; other site 266779004175 putative PBP binding loops; other site 266779004176 ABC-ATPase subunit interface; other site 266779004177 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779004178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779004179 dimer interface [polypeptide binding]; other site 266779004180 conserved gate region; other site 266779004181 putative PBP binding loops; other site 266779004182 ABC-ATPase subunit interface; other site 266779004183 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 266779004184 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779004185 Walker A/P-loop; other site 266779004186 ATP binding site [chemical binding]; other site 266779004187 Q-loop/lid; other site 266779004188 ABC transporter signature motif; other site 266779004189 Walker B; other site 266779004190 D-loop; other site 266779004191 H-loop/switch region; other site 266779004192 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266779004193 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266779004194 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779004195 Walker A/P-loop; other site 266779004196 ATP binding site [chemical binding]; other site 266779004197 Q-loop/lid; other site 266779004198 ABC transporter signature motif; other site 266779004199 Walker B; other site 266779004200 D-loop; other site 266779004201 H-loop/switch region; other site 266779004202 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266779004203 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 266779004204 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266779004205 hypothetical protein; Provisional; Region: PRK10279 266779004206 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 266779004207 nucleophile elbow; other site 266779004208 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 266779004209 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 266779004210 GTP cyclohydrolase I; Provisional; Region: PLN03044 266779004211 active site 266779004212 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 266779004213 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 266779004214 trimerization site [polypeptide binding]; other site 266779004215 active site 266779004216 hypothetical protein; Validated; Region: PRK00041 266779004217 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 266779004218 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 266779004219 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 266779004220 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 266779004221 active site 266779004222 dimer interface [polypeptide binding]; other site 266779004223 motif 1; other site 266779004224 motif 2; other site 266779004225 motif 3; other site 266779004226 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 266779004227 anticodon binding site; other site 266779004228 Domain of unknown function (DUF955); Region: DUF955; pfam06114 266779004229 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 266779004230 putative FMN binding site [chemical binding]; other site 266779004231 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266779004232 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 266779004233 putative active site [active] 266779004234 putative catalytic site [active] 266779004235 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 266779004236 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 266779004237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779004238 Mg2+ binding site [ion binding]; other site 266779004239 G-X-G motif; other site 266779004240 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 266779004241 anchoring element; other site 266779004242 dimer interface [polypeptide binding]; other site 266779004243 ATP binding site [chemical binding]; other site 266779004244 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 266779004245 active site 266779004246 metal binding site [ion binding]; metal-binding site 266779004247 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 266779004248 glycine dehydrogenase; Provisional; Region: PRK05367 266779004249 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 266779004250 tetramer interface [polypeptide binding]; other site 266779004251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779004252 catalytic residue [active] 266779004253 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 266779004254 tetramer interface [polypeptide binding]; other site 266779004255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779004256 catalytic residue [active] 266779004257 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 266779004258 lipoyl attachment site [posttranslational modification]; other site 266779004259 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 266779004260 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266779004261 hypothetical protein; Validated; Region: PRK00124 266779004262 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 266779004263 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266779004264 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 266779004265 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266779004266 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266779004267 carboxyltransferase (CT) interaction site; other site 266779004268 biotinylation site [posttranslational modification]; other site 266779004269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 266779004270 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 266779004271 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 266779004272 NADH dehydrogenase subunit B; Validated; Region: PRK06411 266779004273 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 266779004274 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 266779004275 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 266779004276 NADH dehydrogenase subunit D; Validated; Region: PRK06075 266779004277 NADH dehydrogenase subunit E; Validated; Region: PRK07539 266779004278 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 266779004279 putative dimer interface [polypeptide binding]; other site 266779004280 [2Fe-2S] cluster binding site [ion binding]; other site 266779004281 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 266779004282 SLBB domain; Region: SLBB; pfam10531 266779004283 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 266779004284 NADH dehydrogenase subunit G; Validated; Region: PRK09130 266779004285 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266779004286 catalytic loop [active] 266779004287 iron binding site [ion binding]; other site 266779004288 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 266779004289 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 266779004290 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 266779004291 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 266779004292 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 266779004293 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 266779004294 4Fe-4S binding domain; Region: Fer4; cl02805 266779004295 4Fe-4S binding domain; Region: Fer4; pfam00037 266779004296 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 266779004297 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 266779004298 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 266779004299 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 266779004300 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 266779004301 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 266779004302 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266779004303 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 266779004304 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 266779004305 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266779004306 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 266779004307 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266779004308 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 266779004309 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 266779004310 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 266779004311 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 266779004312 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266779004313 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 266779004314 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266779004315 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 266779004316 dimer interface [polypeptide binding]; other site 266779004317 substrate binding site [chemical binding]; other site 266779004318 metal binding site [ion binding]; metal-binding site 266779004319 Protein of unknown function (DUF1467); Region: DUF1467; cl11569 266779004320 prolyl-tRNA synthetase; Provisional; Region: PRK12325 266779004321 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 266779004322 dimer interface [polypeptide binding]; other site 266779004323 motif 1; other site 266779004324 active site 266779004325 motif 2; other site 266779004326 motif 3; other site 266779004327 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 266779004328 anticodon binding site; other site 266779004329 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 266779004330 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266779004331 FtsX-like permease family; Region: FtsX; pfam02687 266779004332 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266779004333 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266779004334 Walker A/P-loop; other site 266779004335 ATP binding site [chemical binding]; other site 266779004336 Q-loop/lid; other site 266779004337 ABC transporter signature motif; other site 266779004338 Walker B; other site 266779004339 D-loop; other site 266779004340 H-loop/switch region; other site 266779004341 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 266779004342 dimer interface [polypeptide binding]; other site 266779004343 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266779004344 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 266779004345 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266779004346 lipoate-protein ligase B; Provisional; Region: PRK14341 266779004347 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 266779004348 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 266779004349 putative ion selectivity filter; other site 266779004350 putative pore gating glutamate residue; other site 266779004351 putative H+/Cl- coupling transport residue; other site 266779004352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266779004353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 266779004354 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266779004355 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 266779004356 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 266779004357 Uncharacterized conserved protein [Function unknown]; Region: COG3391 266779004358 NHL repeat; Region: NHL; pfam01436 266779004359 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266779004360 PYR/PP interface [polypeptide binding]; other site 266779004361 dimer interface [polypeptide binding]; other site 266779004362 TPP binding site [chemical binding]; other site 266779004363 hypothetical protein; Provisional; Region: PRK06163 266779004364 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 266779004365 TPP-binding site [chemical binding]; other site 266779004366 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266779004367 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266779004368 tetramerization interface [polypeptide binding]; other site 266779004369 NAD(P) binding site [chemical binding]; other site 266779004370 catalytic residues [active] 266779004371 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266779004372 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 266779004373 putative NAD(P) binding site [chemical binding]; other site 266779004374 putative active site [active] 266779004375 EamA-like transporter family; Region: EamA; cl17759 266779004376 NHL repeat; Region: NHL; pfam01436 266779004377 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 266779004378 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 266779004379 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266779004380 putative ligand binding site [chemical binding]; other site 266779004381 putative NAD binding site [chemical binding]; other site 266779004382 catalytic site [active] 266779004383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266779004384 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266779004385 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266779004386 active site 266779004387 metal binding site [ion binding]; metal-binding site 266779004388 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266779004389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779004390 DNA-binding site [nucleotide binding]; DNA binding site 266779004391 FCD domain; Region: FCD; pfam07729 266779004392 thiamine pyrophosphate protein; Validated; Region: PRK08199 266779004393 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266779004394 PYR/PP interface [polypeptide binding]; other site 266779004395 dimer interface [polypeptide binding]; other site 266779004396 TPP binding site [chemical binding]; other site 266779004397 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266779004398 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266779004399 TPP-binding site [chemical binding]; other site 266779004400 hypothetical protein; Validated; Region: PRK06201 266779004401 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 266779004402 tricarballylate dehydrogenase; Validated; Region: PRK08274 266779004403 Predicted oxidoreductase [General function prediction only]; Region: COG3573 266779004404 Predicted oxidoreductase [General function prediction only]; Region: COG3573 266779004405 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 266779004406 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266779004407 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 266779004408 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266779004409 PYR/PP interface [polypeptide binding]; other site 266779004410 dimer interface [polypeptide binding]; other site 266779004411 TPP binding site [chemical binding]; other site 266779004412 hypothetical protein; Provisional; Region: PRK06163 266779004413 Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six...; Region: TPP_ComE; cd03372 266779004414 TPP-binding site; other site 266779004415 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266779004416 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 266779004417 putative active site pocket [active] 266779004418 metal binding site [ion binding]; metal-binding site 266779004419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266779004420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266779004421 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266779004422 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266779004423 active site pocket [active] 266779004424 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266779004425 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 266779004426 putative ligand binding site [chemical binding]; other site 266779004427 NAD binding site [chemical binding]; other site 266779004428 catalytic site [active] 266779004429 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266779004430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266779004431 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 266779004432 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266779004433 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 266779004434 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266779004435 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 266779004436 putative ligand binding site [chemical binding]; other site 266779004437 NAD binding site [chemical binding]; other site 266779004438 catalytic site [active] 266779004439 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266779004440 Predicted dehydrogenase [General function prediction only]; Region: COG0579 266779004441 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 266779004442 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266779004443 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266779004444 active site 266779004445 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 266779004446 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 266779004447 MgtE intracellular N domain; Region: MgtE_N; smart00924 266779004448 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 266779004449 Divalent cation transporter; Region: MgtE; pfam01769 266779004450 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 266779004451 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 266779004452 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 266779004453 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 266779004454 putative catalytic site [active] 266779004455 putative phosphate binding site [ion binding]; other site 266779004456 active site 266779004457 metal binding site A [ion binding]; metal-binding site 266779004458 DNA binding site [nucleotide binding] 266779004459 putative AP binding site [nucleotide binding]; other site 266779004460 putative metal binding site B [ion binding]; other site 266779004461 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 266779004462 Domain of unknown function (DUF305); Region: DUF305; cl17794 266779004463 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266779004464 MarR family; Region: MarR_2; pfam12802 266779004465 MarR family; Region: MarR_2; cl17246 266779004466 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 266779004467 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 266779004468 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 266779004469 DctM-like transporters; Region: DctM; pfam06808 266779004470 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 266779004471 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266779004472 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266779004473 DNA binding site [nucleotide binding] 266779004474 domain linker motif; other site 266779004475 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266779004476 dimerization interface [polypeptide binding]; other site 266779004477 ligand binding site [chemical binding]; other site 266779004478 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266779004479 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266779004480 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 266779004481 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 266779004482 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266779004483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779004484 dimer interface [polypeptide binding]; other site 266779004485 conserved gate region; other site 266779004486 putative PBP binding loops; other site 266779004487 ABC-ATPase subunit interface; other site 266779004488 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 266779004489 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266779004490 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266779004491 Walker A/P-loop; other site 266779004492 ATP binding site [chemical binding]; other site 266779004493 Q-loop/lid; other site 266779004494 ABC transporter signature motif; other site 266779004495 Walker B; other site 266779004496 D-loop; other site 266779004497 H-loop/switch region; other site 266779004498 TOBE domain; Region: TOBE_2; pfam08402 266779004499 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 266779004500 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 266779004501 cystathionine beta-lyase; Provisional; Region: PRK05967 266779004502 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266779004503 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266779004504 catalytic residue [active] 266779004505 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 266779004506 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266779004507 substrate binding pocket [chemical binding]; other site 266779004508 membrane-bound complex binding site; other site 266779004509 hinge residues; other site 266779004510 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 266779004511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779004512 conserved gate region; other site 266779004513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779004514 dimer interface [polypeptide binding]; other site 266779004515 conserved gate region; other site 266779004516 putative PBP binding loops; other site 266779004517 ABC-ATPase subunit interface; other site 266779004518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779004519 dimer interface [polypeptide binding]; other site 266779004520 conserved gate region; other site 266779004521 putative PBP binding loops; other site 266779004522 ABC-ATPase subunit interface; other site 266779004523 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266779004524 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266779004525 Walker A/P-loop; other site 266779004526 ATP binding site [chemical binding]; other site 266779004527 Q-loop/lid; other site 266779004528 ABC transporter signature motif; other site 266779004529 Walker B; other site 266779004530 D-loop; other site 266779004531 H-loop/switch region; other site 266779004532 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266779004533 salicylate hydroxylase; Provisional; Region: PRK08163 266779004534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 266779004535 polyphosphate kinase; Provisional; Region: PRK05443 266779004536 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 266779004537 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 266779004538 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 266779004539 putative domain interface [polypeptide binding]; other site 266779004540 putative active site [active] 266779004541 catalytic site [active] 266779004542 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 266779004543 putative domain interface [polypeptide binding]; other site 266779004544 putative active site [active] 266779004545 catalytic site [active] 266779004546 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 266779004547 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 266779004548 ribonuclease D; Region: rnd; TIGR01388 266779004549 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 266779004550 catalytic site [active] 266779004551 putative active site [active] 266779004552 putative substrate binding site [chemical binding]; other site 266779004553 HRDC domain; Region: HRDC; pfam00570 266779004554 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 266779004555 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 266779004556 dimer interface [polypeptide binding]; other site 266779004557 anticodon binding site; other site 266779004558 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 266779004559 homodimer interface [polypeptide binding]; other site 266779004560 motif 1; other site 266779004561 active site 266779004562 motif 2; other site 266779004563 GAD domain; Region: GAD; pfam02938 266779004564 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 266779004565 active site 266779004566 motif 3; other site 266779004567 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 266779004568 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 266779004569 CAP-like domain; other site 266779004570 active site 266779004571 primary dimer interface [polypeptide binding]; other site 266779004572 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 266779004573 putative hydrophobic ligand binding site [chemical binding]; other site 266779004574 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 266779004575 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 266779004576 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 266779004577 RDD family; Region: RDD; pfam06271 266779004578 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 266779004579 dimer interface [polypeptide binding]; other site 266779004580 allosteric magnesium binding site [ion binding]; other site 266779004581 active site 266779004582 aspartate-rich active site metal binding site; other site 266779004583 Schiff base residues; other site 266779004584 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 266779004585 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266779004586 substrate binding site [chemical binding]; other site 266779004587 oxyanion hole (OAH) forming residues; other site 266779004588 trimer interface [polypeptide binding]; other site 266779004589 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 266779004590 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266779004591 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 266779004592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 266779004593 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266779004594 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266779004595 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266779004596 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 266779004597 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 266779004598 dimer interface [polypeptide binding]; other site 266779004599 active site 266779004600 glycine-pyridoxal phosphate binding site [chemical binding]; other site 266779004601 folate binding site [chemical binding]; other site 266779004602 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 266779004603 ATP cone domain; Region: ATP-cone; pfam03477 266779004604 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 266779004605 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 266779004606 catalytic motif [active] 266779004607 Zn binding site [ion binding]; other site 266779004608 RibD C-terminal domain; Region: RibD_C; cl17279 266779004609 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 266779004610 Lumazine binding domain; Region: Lum_binding; pfam00677 266779004611 Lumazine binding domain; Region: Lum_binding; pfam00677 266779004612 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 266779004613 homopentamer interface [polypeptide binding]; other site 266779004614 active site 266779004615 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 266779004616 putative RNA binding site [nucleotide binding]; other site 266779004617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779004618 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266779004619 putative substrate translocation pore; other site 266779004620 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 266779004621 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 266779004622 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 266779004623 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 266779004624 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 266779004625 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 266779004626 putative phosphate acyltransferase; Provisional; Region: PRK05331 266779004627 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 266779004628 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 266779004629 dimer interface [polypeptide binding]; other site 266779004630 active site 266779004631 CoA binding pocket [chemical binding]; other site 266779004632 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266779004633 IHF dimer interface [polypeptide binding]; other site 266779004634 IHF - DNA interface [nucleotide binding]; other site 266779004635 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 266779004636 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266779004637 DNA binding residues [nucleotide binding] 266779004638 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 266779004639 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 266779004640 putative DNA binding site [nucleotide binding]; other site 266779004641 putative homodimer interface [polypeptide binding]; other site 266779004642 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 266779004643 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 266779004644 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 266779004645 active site 266779004646 DNA binding site [nucleotide binding] 266779004647 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 266779004648 DNA binding site [nucleotide binding] 266779004649 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 266779004650 nucleotide binding site [chemical binding]; other site 266779004651 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 266779004652 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 266779004653 putative DNA binding site [nucleotide binding]; other site 266779004654 putative homodimer interface [polypeptide binding]; other site 266779004655 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 266779004656 O-Antigen ligase; Region: Wzy_C; cl04850 266779004657 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 266779004658 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 266779004659 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266779004660 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266779004661 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266779004662 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 266779004663 SLBB domain; Region: SLBB; pfam10531 266779004664 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 266779004665 Chain length determinant protein; Region: Wzz; pfam02706 266779004666 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 266779004667 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 266779004668 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 266779004669 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 266779004670 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 266779004671 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 266779004672 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266779004673 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 266779004674 agmatinase; Region: agmatinase; TIGR01230 266779004675 oligomer interface [polypeptide binding]; other site 266779004676 putative active site [active] 266779004677 Mn binding site [ion binding]; other site 266779004678 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 266779004679 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 266779004680 23S rRNA interface [nucleotide binding]; other site 266779004681 L3 interface [polypeptide binding]; other site 266779004682 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266779004683 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 266779004684 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 266779004685 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 266779004686 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266779004687 homodimer interface [polypeptide binding]; other site 266779004688 substrate-cofactor binding pocket; other site 266779004689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779004690 catalytic residue [active] 266779004691 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 266779004692 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 266779004693 oligomer interface [polypeptide binding]; other site 266779004694 active site residues [active] 266779004695 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 266779004696 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 266779004697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779004698 Walker A motif; other site 266779004699 ATP binding site [chemical binding]; other site 266779004700 Walker B motif; other site 266779004701 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 266779004702 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 266779004703 Found in ATP-dependent protease La (LON); Region: LON; smart00464 266779004704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779004705 Walker A motif; other site 266779004706 ATP binding site [chemical binding]; other site 266779004707 Walker B motif; other site 266779004708 arginine finger; other site 266779004709 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 266779004710 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266779004711 IHF dimer interface [polypeptide binding]; other site 266779004712 IHF - DNA interface [nucleotide binding]; other site 266779004713 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266779004714 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 266779004715 active site 266779004716 FMN binding site [chemical binding]; other site 266779004717 substrate binding site [chemical binding]; other site 266779004718 homotetramer interface [polypeptide binding]; other site 266779004719 catalytic residue [active] 266779004720 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 266779004721 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 266779004722 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 266779004723 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 266779004724 LssY C-terminus; Region: LssY_C; pfam14067 266779004725 Ion channel; Region: Ion_trans_2; pfam07885 266779004726 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 266779004727 nudix motif; other site 266779004728 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266779004729 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266779004730 active site 266779004731 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266779004732 HSP70 interaction site [polypeptide binding]; other site 266779004733 RecT family; Region: RecT; cl04285 266779004734 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 266779004735 Domain of unknown function (DUF955); Region: DUF955; pfam06114 266779004736 Predicted transcriptional regulator [Transcription]; Region: COG2932 266779004737 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 266779004738 Catalytic site [active] 266779004739 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266779004740 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266779004741 ATP binding site [chemical binding]; other site 266779004742 putative Mg++ binding site [ion binding]; other site 266779004743 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266779004744 nucleotide binding region [chemical binding]; other site 266779004745 ATP-binding site [chemical binding]; other site 266779004746 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 266779004747 DNA methylase; Region: N6_N4_Mtase; pfam01555 266779004748 replicative DNA helicase; Provisional; Region: PRK09165 266779004749 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 266779004750 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266779004751 Walker A motif; other site 266779004752 ATP binding site [chemical binding]; other site 266779004753 Walker B motif; other site 266779004754 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266779004755 active site 266779004756 catalytic residues [active] 266779004757 DNA binding site [nucleotide binding] 266779004758 Int/Topo IB signature motif; other site 266779004759 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 266779004760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 266779004761 Terminase-like family; Region: Terminase_6; pfam03237 266779004762 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 266779004763 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 266779004764 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 266779004765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566 266779004766 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 266779004767 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 266779004768 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 266779004769 CsbD-like; Region: CsbD; pfam05532 266779004770 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 266779004771 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 266779004772 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 266779004773 Putative phage tail protein; Region: Phage-tail_3; pfam13550 266779004774 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 266779004775 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 266779004776 RNA polymerase sigma factor; Provisional; Region: PRK11922 266779004777 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266779004778 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266779004779 DNA binding residues [nucleotide binding] 266779004780 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 266779004781 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 266779004782 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 266779004783 oligomer interface [polypeptide binding]; other site 266779004784 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 266779004785 pentamer interface [polypeptide binding]; other site 266779004786 dodecaamer interface [polypeptide binding]; other site 266779004787 Uncharacterized conserved protein [Function unknown]; Region: COG2135 266779004788 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 266779004789 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 266779004790 Catalytic site; other site 266779004791 glucose-1-dehydrogenase; Provisional; Region: PRK06947 266779004792 classical (c) SDRs; Region: SDR_c; cd05233 266779004793 NAD(P) binding site [chemical binding]; other site 266779004794 active site 266779004795 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 266779004796 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 266779004797 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 266779004798 putative active site [active] 266779004799 putative PHP Thumb interface [polypeptide binding]; other site 266779004800 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 266779004801 generic binding surface II; other site 266779004802 generic binding surface I; other site 266779004803 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 266779004804 Uncharacterized conserved protein [Function unknown]; Region: COG1434 266779004805 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 266779004806 putative active site [active] 266779004807 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 266779004808 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 266779004809 DNA binding residues [nucleotide binding] 266779004810 putative dimer interface [polypeptide binding]; other site 266779004811 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266779004812 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 266779004813 putative outer membrane lipoprotein; Provisional; Region: PRK10510 266779004814 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266779004815 ligand binding site [chemical binding]; other site 266779004816 recombinase A; Provisional; Region: recA; PRK09354 266779004817 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 266779004818 hexamer interface [polypeptide binding]; other site 266779004819 Walker A motif; other site 266779004820 ATP binding site [chemical binding]; other site 266779004821 Walker B motif; other site 266779004822 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266779004823 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 266779004824 substrate binding site [chemical binding]; other site 266779004825 ATP binding site [chemical binding]; other site 266779004826 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 266779004827 Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013 266779004828 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 266779004829 motif 1; other site 266779004830 active site 266779004831 motif 2; other site 266779004832 motif 3; other site 266779004833 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 266779004834 isocitrate dehydrogenase; Validated; Region: PRK08299 266779004835 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 266779004836 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 266779004837 glutamate racemase; Provisional; Region: PRK00865 266779004838 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 266779004839 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 266779004840 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266779004841 RNA binding surface [nucleotide binding]; other site 266779004842 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 266779004843 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 266779004844 Ligand Binding Site [chemical binding]; other site 266779004845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779004846 putative substrate translocation pore; other site 266779004847 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 266779004848 putative GSH binding site [chemical binding]; other site 266779004849 catalytic residues [active] 266779004850 BioY family; Region: BioY; pfam02632 266779004851 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 266779004852 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 266779004853 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 266779004854 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 266779004855 dimerization interface [polypeptide binding]; other site 266779004856 ATP binding site [chemical binding]; other site 266779004857 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 266779004858 dimerization interface [polypeptide binding]; other site 266779004859 ATP binding site [chemical binding]; other site 266779004860 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 266779004861 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 266779004862 putative active site [active] 266779004863 catalytic triad [active] 266779004864 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 266779004865 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 266779004866 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 266779004867 ATP binding site [chemical binding]; other site 266779004868 active site 266779004869 substrate binding site [chemical binding]; other site 266779004870 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 266779004871 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 266779004872 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266779004873 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 266779004874 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 266779004875 putative metal binding site [ion binding]; other site 266779004876 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266779004877 active site 266779004878 adenylosuccinate lyase; Provisional; Region: PRK07492 266779004879 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 266779004880 tetramer interface [polypeptide binding]; other site 266779004881 active site 266779004882 Predicted secreted protein (DUF2259); Region: DUF2259; pfam10016 266779004883 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 266779004884 putative active site pocket [active] 266779004885 cleavage site 266779004886 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266779004887 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 266779004888 ligand binding site [chemical binding]; other site 266779004889 Flavin Reductases; Region: FlaRed; cl00801 266779004890 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 266779004891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779004892 Walker A motif; other site 266779004893 ATP binding site [chemical binding]; other site 266779004894 Walker B motif; other site 266779004895 arginine finger; other site 266779004896 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 266779004897 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266779004898 metal ion-dependent adhesion site (MIDAS); other site 266779004899 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266779004900 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 266779004901 XdhC Rossmann domain; Region: XdhC_C; pfam13478 266779004902 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 266779004903 putative MPT binding site; other site 266779004904 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 266779004905 Ligand binding site; other site 266779004906 metal-binding site 266779004907 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266779004908 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 266779004909 multidrug efflux protein; Reviewed; Region: PRK01766 266779004910 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 266779004911 cation binding site [ion binding]; other site 266779004912 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266779004913 metal ion-dependent adhesion site (MIDAS); other site 266779004914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779004915 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266779004916 dimerization interface [polypeptide binding]; other site 266779004917 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 266779004918 nucleotide binding site [chemical binding]; other site 266779004919 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 266779004920 Domain of unknown function (DUF4354); Region: DUF4354; pfam14263 266779004921 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266779004922 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 266779004923 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 266779004924 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266779004925 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 266779004926 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779004927 Walker A/P-loop; other site 266779004928 ATP binding site [chemical binding]; other site 266779004929 Q-loop/lid; other site 266779004930 ABC transporter signature motif; other site 266779004931 Walker B; other site 266779004932 D-loop; other site 266779004933 H-loop/switch region; other site 266779004934 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779004935 Walker A/P-loop; other site 266779004936 ATP binding site [chemical binding]; other site 266779004937 Q-loop/lid; other site 266779004938 ABC transporter signature motif; other site 266779004939 Walker B; other site 266779004940 D-loop; other site 266779004941 H-loop/switch region; other site 266779004942 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266779004943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779004944 dimer interface [polypeptide binding]; other site 266779004945 conserved gate region; other site 266779004946 putative PBP binding loops; other site 266779004947 ABC-ATPase subunit interface; other site 266779004948 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779004949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779004950 dimer interface [polypeptide binding]; other site 266779004951 conserved gate region; other site 266779004952 putative PBP binding loops; other site 266779004953 ABC-ATPase subunit interface; other site 266779004954 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266779004955 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 266779004956 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266779004957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266779004958 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 266779004959 putative acyl-acceptor binding pocket; other site 266779004960 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266779004961 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266779004962 NAD(P) binding site [chemical binding]; other site 266779004963 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 266779004964 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266779004965 dimer interface [polypeptide binding]; other site 266779004966 active site 266779004967 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 266779004968 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 266779004969 active site 266779004970 acyl carrier protein; Provisional; Region: PRK06508 266779004971 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266779004972 catalytic core [active] 266779004973 Predicted permeases [General function prediction only]; Region: COG0679 266779004974 succinic semialdehyde dehydrogenase; Region: PLN02278 266779004975 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266779004976 tetramerization interface [polypeptide binding]; other site 266779004977 NAD(P) binding site [chemical binding]; other site 266779004978 catalytic residues [active] 266779004979 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779004980 putative DNA binding site [nucleotide binding]; other site 266779004981 putative Zn2+ binding site [ion binding]; other site 266779004982 AsnC family; Region: AsnC_trans_reg; pfam01037 266779004983 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 266779004984 Proline dehydrogenase; Region: Pro_dh; pfam01619 266779004985 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 266779004986 Glutamate binding site [chemical binding]; other site 266779004987 NAD binding site [chemical binding]; other site 266779004988 catalytic residues [active] 266779004989 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266779004990 hydrophobic ligand binding site; other site 266779004991 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266779004992 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 266779004993 GIY-YIG motif/motif A; other site 266779004994 putative active site [active] 266779004995 putative metal binding site [ion binding]; other site 266779004996 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 266779004997 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 266779004998 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 266779004999 C2 domain; Region: C2; cl14603 266779005000 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 266779005001 active site 266779005002 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 266779005003 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 266779005004 TSCPD domain; Region: TSCPD; pfam12637 266779005005 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 266779005006 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 266779005007 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 266779005008 nudix motif; other site 266779005009 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266779005010 active site 266779005011 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 266779005012 oligomer interface [polypeptide binding]; other site 266779005013 active site residues [active] 266779005014 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 266779005015 Domain of unknown function (DUF305); Region: DUF305; cl17794 266779005016 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266779005017 Ligand Binding Site [chemical binding]; other site 266779005018 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266779005019 Ligand Binding Site [chemical binding]; other site 266779005020 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 266779005021 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 266779005022 putative MPT binding site; other site 266779005023 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 266779005024 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266779005025 Predicted membrane protein [Function unknown]; Region: COG4655 266779005026 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 266779005027 DNA polymerase IV; Provisional; Region: PRK02794 266779005028 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 266779005029 active site 266779005030 DNA binding site [nucleotide binding] 266779005031 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266779005032 Coenzyme A binding pocket [chemical binding]; other site 266779005033 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 266779005034 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266779005035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779005036 active site 266779005037 phosphorylation site [posttranslational modification] 266779005038 intermolecular recognition site; other site 266779005039 dimerization interface [polypeptide binding]; other site 266779005040 response regulator PleD; Reviewed; Region: pleD; PRK09581 266779005041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779005042 active site 266779005043 phosphorylation site [posttranslational modification] 266779005044 intermolecular recognition site; other site 266779005045 dimerization interface [polypeptide binding]; other site 266779005046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779005047 active site 266779005048 phosphorylation site [posttranslational modification] 266779005049 dimerization interface [polypeptide binding]; other site 266779005050 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266779005051 metal binding site [ion binding]; metal-binding site 266779005052 active site 266779005053 I-site; other site 266779005054 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 266779005055 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266779005056 nudix motif; other site 266779005057 hypothetical protein; Provisional; Region: PRK05978 266779005058 ribonuclease R; Region: RNase_R; TIGR02063 266779005059 RNB domain; Region: RNB; pfam00773 266779005060 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 266779005061 RNA binding site [nucleotide binding]; other site 266779005062 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 266779005063 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 266779005064 active site 266779005065 interdomain interaction site; other site 266779005066 putative metal-binding site [ion binding]; other site 266779005067 nucleotide binding site [chemical binding]; other site 266779005068 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 266779005069 domain I; other site 266779005070 DNA binding groove [nucleotide binding] 266779005071 phosphate binding site [ion binding]; other site 266779005072 domain II; other site 266779005073 domain III; other site 266779005074 nucleotide binding site [chemical binding]; other site 266779005075 catalytic site [active] 266779005076 domain IV; other site 266779005077 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 266779005078 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 266779005079 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 266779005080 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 266779005081 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 266779005082 DNA protecting protein DprA; Region: dprA; TIGR00732 266779005083 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 266779005084 dihydroorotase; Validated; Region: PRK09059 266779005085 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266779005086 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 266779005087 active site 266779005088 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 266779005089 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266779005090 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 266779005091 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266779005092 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266779005093 active site 266779005094 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 266779005095 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 266779005096 metal-dependent hydrolase; Provisional; Region: PRK00685 266779005097 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 266779005098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266779005099 Coenzyme A binding pocket [chemical binding]; other site 266779005100 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266779005101 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 266779005102 Uncharacterized conserved protein [Function unknown]; Region: COG1434 266779005103 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 266779005104 putative active site [active] 266779005105 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 266779005106 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 266779005107 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 266779005108 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 266779005109 von Willebrand factor type A domain; Region: VWA_2; pfam13519 266779005110 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266779005111 HSP70 interaction site [polypeptide binding]; other site 266779005112 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 266779005113 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 266779005114 Sporulation related domain; Region: SPOR; pfam05036 266779005115 Uncharacterized conserved protein [Function unknown]; Region: COG2127 266779005116 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 266779005117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779005118 Walker A motif; other site 266779005119 ATP binding site [chemical binding]; other site 266779005120 Walker B motif; other site 266779005121 arginine finger; other site 266779005122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779005123 Walker A motif; other site 266779005124 ATP binding site [chemical binding]; other site 266779005125 Walker B motif; other site 266779005126 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 266779005127 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 266779005128 O-Antigen ligase; Region: Wzy_C; pfam04932 266779005129 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 266779005130 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 266779005131 HIT family signature motif; other site 266779005132 catalytic residue [active] 266779005133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 266779005134 Protein of unknown function, DUF482; Region: DUF482; pfam04339 266779005135 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 266779005136 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 266779005137 putative active site [active] 266779005138 catalytic site [active] 266779005139 putative metal binding site [ion binding]; other site 266779005140 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 266779005141 homotrimer interaction site [polypeptide binding]; other site 266779005142 putative active site [active] 266779005143 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 266779005144 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 266779005145 rRNA interaction site [nucleotide binding]; other site 266779005146 S8 interaction site; other site 266779005147 putative laminin-1 binding site; other site 266779005148 elongation factor Ts; Provisional; Region: tsf; PRK09377 266779005149 UBA/TS-N domain; Region: UBA; pfam00627 266779005150 Elongation factor TS; Region: EF_TS; pfam00889 266779005151 Elongation factor TS; Region: EF_TS; pfam00889 266779005152 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 266779005153 putative nucleotide binding site [chemical binding]; other site 266779005154 uridine monophosphate binding site [chemical binding]; other site 266779005155 homohexameric interface [polypeptide binding]; other site 266779005156 ribosome recycling factor; Reviewed; Region: frr; PRK00083 266779005157 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 266779005158 hinge region; other site 266779005159 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 266779005160 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 266779005161 catalytic residue [active] 266779005162 putative FPP diphosphate binding site; other site 266779005163 putative FPP binding hydrophobic cleft; other site 266779005164 dimer interface [polypeptide binding]; other site 266779005165 putative IPP diphosphate binding site; other site 266779005166 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 266779005167 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 266779005168 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 266779005169 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 266779005170 active site 266779005171 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 266779005172 protein binding site [polypeptide binding]; other site 266779005173 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 266779005174 putative substrate binding region [chemical binding]; other site 266779005175 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 266779005176 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 266779005177 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266779005178 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266779005179 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266779005180 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266779005181 Surface antigen; Region: Bac_surface_Ag; pfam01103 266779005182 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 266779005183 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 266779005184 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 266779005185 trimer interface [polypeptide binding]; other site 266779005186 active site 266779005187 UDP-GlcNAc binding site [chemical binding]; other site 266779005188 lipid binding site [chemical binding]; lipid-binding site 266779005189 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 266779005190 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 266779005191 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 266779005192 active site 266779005193 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 266779005194 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 266779005195 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 266779005196 Protein of unknown function DUF72; Region: DUF72; pfam01904 266779005197 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266779005198 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266779005199 C-terminal domain interface [polypeptide binding]; other site 266779005200 GSH binding site (G-site) [chemical binding]; other site 266779005201 dimer interface [polypeptide binding]; other site 266779005202 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 266779005203 N-terminal domain interface [polypeptide binding]; other site 266779005204 dimer interface [polypeptide binding]; other site 266779005205 substrate binding pocket (H-site) [chemical binding]; other site 266779005206 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 266779005207 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266779005208 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266779005209 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 266779005210 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 266779005211 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 266779005212 dimer interface [polypeptide binding]; other site 266779005213 ssDNA binding site [nucleotide binding]; other site 266779005214 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266779005215 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 266779005216 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 266779005217 DNA gyrase subunit A; Validated; Region: PRK05560 266779005218 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 266779005219 CAP-like domain; other site 266779005220 active site 266779005221 primary dimer interface [polypeptide binding]; other site 266779005222 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266779005223 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266779005224 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266779005225 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266779005226 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266779005227 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266779005228 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 266779005229 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 266779005230 active site 266779005231 (T/H)XGH motif; other site 266779005232 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 266779005233 active site 266779005234 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 266779005235 active site 266779005236 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 266779005237 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 266779005238 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 266779005239 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 266779005240 Autoinducer binding domain; Region: Autoind_bind; pfam03472 266779005241 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266779005242 DNA binding residues [nucleotide binding] 266779005243 dimerization interface [polypeptide binding]; other site 266779005244 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 266779005245 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 266779005246 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266779005247 catalytic loop [active] 266779005248 iron binding site [ion binding]; other site 266779005249 Bacterial protein of unknown function (DUF922); Region: DUF922; pfam06037 266779005250 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 266779005251 dihydropteroate synthase; Region: DHPS; TIGR01496 266779005252 substrate binding pocket [chemical binding]; other site 266779005253 dimer interface [polypeptide binding]; other site 266779005254 inhibitor binding site; inhibition site 266779005255 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 266779005256 homooctamer interface [polypeptide binding]; other site 266779005257 active site 266779005258 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 266779005259 catalytic center binding site [active] 266779005260 ATP binding site [chemical binding]; other site 266779005261 Predicted membrane protein [Function unknown]; Region: COG3768 266779005262 Domain of unknown function (DUF697); Region: DUF697; cl12064 266779005263 YcjX-like family, DUF463; Region: DUF463; pfam04317 266779005264 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266779005265 catalytic core [active] 266779005266 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 266779005267 threonine dehydratase; Validated; Region: PRK08639 266779005268 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266779005269 tetramer interface [polypeptide binding]; other site 266779005270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779005271 catalytic residue [active] 266779005272 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 266779005273 putative Ile/Val binding site [chemical binding]; other site 266779005274 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 266779005275 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 266779005276 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266779005277 ATP binding site [chemical binding]; other site 266779005278 Mg++ binding site [ion binding]; other site 266779005279 motif III; other site 266779005280 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266779005281 nucleotide binding region [chemical binding]; other site 266779005282 ATP-binding site [chemical binding]; other site 266779005283 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266779005284 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266779005285 dimer interface [polypeptide binding]; other site 266779005286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779005287 catalytic residue [active] 266779005288 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266779005289 Secretory lipase; Region: LIP; pfam03583 266779005290 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 266779005291 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 266779005292 active site residue [active] 266779005293 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 266779005294 active site residue [active] 266779005295 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266779005296 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 266779005297 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 266779005298 hexamer interface [polypeptide binding]; other site 266779005299 ligand binding site [chemical binding]; other site 266779005300 putative active site [active] 266779005301 NAD(P) binding site [chemical binding]; other site 266779005302 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266779005303 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779005304 putative DNA binding site [nucleotide binding]; other site 266779005305 putative Zn2+ binding site [ion binding]; other site 266779005306 AsnC family; Region: AsnC_trans_reg; pfam01037 266779005307 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 266779005308 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 266779005309 Transglycosylase; Region: Transgly; pfam00912 266779005310 BA14K-like protein; Region: BA14K; pfam07886 266779005311 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 266779005312 active site 266779005313 DNA binding site [nucleotide binding] 266779005314 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 266779005315 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 266779005316 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 266779005317 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 266779005318 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 266779005319 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 266779005320 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266779005321 N-terminal plug; other site 266779005322 ligand-binding site [chemical binding]; other site 266779005323 Hemin uptake protein hemP; Region: hemP; pfam10636 266779005324 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 266779005325 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 266779005326 putative hemin binding site; other site 266779005327 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 266779005328 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266779005329 ABC-ATPase subunit interface; other site 266779005330 dimer interface [polypeptide binding]; other site 266779005331 putative PBP binding regions; other site 266779005332 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 266779005333 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 266779005334 Walker A/P-loop; other site 266779005335 ATP binding site [chemical binding]; other site 266779005336 Q-loop/lid; other site 266779005337 ABC transporter signature motif; other site 266779005338 Walker B; other site 266779005339 D-loop; other site 266779005340 H-loop/switch region; other site 266779005341 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 266779005342 Rrf2 family protein; Region: rrf2_super; TIGR00738 266779005343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266779005344 Coenzyme A binding pocket [chemical binding]; other site 266779005345 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 266779005346 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266779005347 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266779005348 DNA binding residues [nucleotide binding] 266779005349 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 266779005350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779005351 active site 266779005352 phosphorylation site [posttranslational modification] 266779005353 intermolecular recognition site; other site 266779005354 ANTAR domain; Region: ANTAR; pfam03861 266779005355 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266779005356 NMT1-like family; Region: NMT1_2; pfam13379 266779005357 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 266779005358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779005359 putative substrate translocation pore; other site 266779005360 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 266779005361 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266779005362 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 266779005363 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 266779005364 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266779005365 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 266779005366 [2Fe-2S] cluster binding site [ion binding]; other site 266779005367 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 266779005368 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 266779005369 [4Fe-4S] binding site [ion binding]; other site 266779005370 molybdopterin cofactor binding site; other site 266779005371 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 266779005372 molybdopterin cofactor binding site; other site 266779005373 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 266779005374 hypothetical protein; Reviewed; Region: PRK00024 266779005375 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 266779005376 MPN+ (JAMM) motif; other site 266779005377 Zinc-binding site [ion binding]; other site 266779005378 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 266779005379 active site 266779005380 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 266779005381 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266779005382 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266779005383 phosphoglycolate phosphatase; Provisional; Region: PRK13222 266779005384 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266779005385 motif II; other site 266779005386 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 266779005387 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266779005388 active site 266779005389 dimer interface [polypeptide binding]; other site 266779005390 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 266779005391 glutathione reductase; Validated; Region: PRK06116 266779005392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266779005393 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266779005394 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266779005395 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 266779005396 NAD synthetase; Provisional; Region: PRK13981 266779005397 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 266779005398 multimer interface [polypeptide binding]; other site 266779005399 active site 266779005400 catalytic triad [active] 266779005401 protein interface 1 [polypeptide binding]; other site 266779005402 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 266779005403 homodimer interface [polypeptide binding]; other site 266779005404 NAD binding pocket [chemical binding]; other site 266779005405 ATP binding pocket [chemical binding]; other site 266779005406 Mg binding site [ion binding]; other site 266779005407 active-site loop [active] 266779005408 DNA primase; Validated; Region: dnaG; PRK05667 266779005409 CHC2 zinc finger; Region: zf-CHC2; pfam01807 266779005410 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 266779005411 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 266779005412 active site 266779005413 metal binding site [ion binding]; metal-binding site 266779005414 interdomain interaction site; other site 266779005415 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 266779005416 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 266779005417 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 266779005418 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266779005419 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 266779005420 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266779005421 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266779005422 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266779005423 DNA binding residues [nucleotide binding] 266779005424 Uncharacterized conserved protein [Function unknown]; Region: COG4274 266779005425 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 266779005426 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 266779005427 dimer interface [polypeptide binding]; other site 266779005428 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 266779005429 putative C-terminal domain interface [polypeptide binding]; other site 266779005430 putative GSH binding site (G-site) [chemical binding]; other site 266779005431 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266779005432 putative dimer interface [polypeptide binding]; other site 266779005433 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 266779005434 dimer interface [polypeptide binding]; other site 266779005435 N-terminal domain interface [polypeptide binding]; other site 266779005436 putative substrate binding pocket (H-site) [chemical binding]; other site 266779005437 Transcriptional activator HlyU; Region: HlyU; pfam10115 266779005438 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 266779005439 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 266779005440 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 266779005441 putative dimer interface [polypeptide binding]; other site 266779005442 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266779005443 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 266779005444 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266779005445 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 266779005446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 266779005447 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 266779005448 active site 266779005449 substrate binding pocket [chemical binding]; other site 266779005450 dimer interface [polypeptide binding]; other site 266779005451 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266779005452 active site 266779005453 Domain of unknown function (DUF378); Region: DUF378; pfam04070 266779005454 Homo sapiens Nbla03831 and related proteins, metallophosphatase domain; Region: MPP_Nbla03831; cd07396 266779005455 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266779005456 active site 266779005457 metal binding site [ion binding]; metal-binding site 266779005458 aspartate aminotransferase; Provisional; Region: PRK05764 266779005459 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266779005460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779005461 homodimer interface [polypeptide binding]; other site 266779005462 catalytic residue [active] 266779005463 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 266779005464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266779005465 non-specific DNA binding site [nucleotide binding]; other site 266779005466 salt bridge; other site 266779005467 sequence-specific DNA binding site [nucleotide binding]; other site 266779005468 Cupin domain; Region: Cupin_2; pfam07883 266779005469 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 266779005470 putative FMN binding site [chemical binding]; other site 266779005471 EF-hand domain pair; Region: EF_hand_5; pfam13499 266779005472 GAF domain; Region: GAF_2; pfam13185 266779005473 GAF domain; Region: GAF; pfam01590 266779005474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266779005475 HWE histidine kinase; Region: HWE_HK; pfam07536 266779005476 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 266779005477 intracellular protease, PfpI family; Region: PfpI; TIGR01382 266779005478 proposed catalytic triad [active] 266779005479 conserved cys residue [active] 266779005480 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266779005481 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266779005482 ligand binding site [chemical binding]; other site 266779005483 flexible hinge region; other site 266779005484 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 266779005485 HerA helicase [Replication, recombination, and repair]; Region: COG0433 266779005486 Domain of unknown function DUF87; Region: DUF87; pfam01935 266779005487 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 266779005488 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266779005489 PYR/PP interface [polypeptide binding]; other site 266779005490 dimer interface [polypeptide binding]; other site 266779005491 TPP binding site [chemical binding]; other site 266779005492 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266779005493 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 266779005494 TPP-binding site [chemical binding]; other site 266779005495 dimer interface [polypeptide binding]; other site 266779005496 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 266779005497 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 266779005498 putative valine binding site [chemical binding]; other site 266779005499 dimer interface [polypeptide binding]; other site 266779005500 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 266779005501 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266779005502 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 266779005503 AAA domain; Region: AAA_30; pfam13604 266779005504 Family description; Region: UvrD_C_2; pfam13538 266779005505 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 266779005506 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541 266779005507 active site 266779005508 hydrophilic channel; other site 266779005509 dimerization interface [polypeptide binding]; other site 266779005510 catalytic residues [active] 266779005511 active site lid [active] 266779005512 ketol-acid reductoisomerase; Provisional; Region: PRK05479 266779005513 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 266779005514 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 266779005515 BA14K-like protein; Region: BA14K; pfam07886 266779005516 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266779005517 putative catalytic site [active] 266779005518 putative metal binding site [ion binding]; other site 266779005519 putative phosphate binding site [ion binding]; other site 266779005520 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 266779005521 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266779005522 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266779005523 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 266779005524 conserved cys residue [active] 266779005525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779005526 Helix-turn-helix domain; Region: HTH_18; pfam12833 266779005527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779005528 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266779005529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779005530 S-adenosylmethionine binding site [chemical binding]; other site 266779005531 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266779005532 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266779005533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779005534 putative PBP binding loops; other site 266779005535 ABC-ATPase subunit interface; other site 266779005536 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779005537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779005538 dimer interface [polypeptide binding]; other site 266779005539 conserved gate region; other site 266779005540 putative PBP binding loops; other site 266779005541 ABC-ATPase subunit interface; other site 266779005542 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 266779005543 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266779005544 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266779005545 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266779005546 non-specific DNA interactions [nucleotide binding]; other site 266779005547 DNA binding site [nucleotide binding] 266779005548 sequence specific DNA binding site [nucleotide binding]; other site 266779005549 putative cAMP binding site [chemical binding]; other site 266779005550 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266779005551 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 266779005552 nucleotide binding site [chemical binding]; other site 266779005553 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 266779005554 active site 266779005555 trimer interface [polypeptide binding]; other site 266779005556 allosteric site; other site 266779005557 active site lid [active] 266779005558 hexamer (dimer of trimers) interface [polypeptide binding]; other site 266779005559 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 266779005560 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266779005561 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266779005562 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779005563 Walker A/P-loop; other site 266779005564 ATP binding site [chemical binding]; other site 266779005565 Q-loop/lid; other site 266779005566 ABC transporter signature motif; other site 266779005567 Walker B; other site 266779005568 D-loop; other site 266779005569 H-loop/switch region; other site 266779005570 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779005571 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779005572 Walker A/P-loop; other site 266779005573 ATP binding site [chemical binding]; other site 266779005574 Q-loop/lid; other site 266779005575 ABC transporter signature motif; other site 266779005576 Walker B; other site 266779005577 D-loop; other site 266779005578 H-loop/switch region; other site 266779005579 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779005580 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266779005581 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266779005582 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266779005583 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266779005584 catalytic residue [active] 266779005585 Sporulation related domain; Region: SPOR; cl10051 266779005586 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 266779005587 conserved repeat domain; Region: B_ant_repeat; TIGR01451 266779005588 Right handed beta helix region; Region: Beta_helix; pfam13229 266779005589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 266779005590 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 266779005591 Family of unknown function (DUF490); Region: DUF490; pfam04357 266779005592 Family of unknown function (DUF490); Region: DUF490; pfam04357 266779005593 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 266779005594 Surface antigen; Region: Bac_surface_Ag; pfam01103 266779005595 acetyl-CoA acetyltransferase; Provisional; Region: PRK08170 266779005596 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266779005597 dimer interface [polypeptide binding]; other site 266779005598 active site 266779005599 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 266779005600 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266779005601 substrate binding site [chemical binding]; other site 266779005602 oxyanion hole (OAH) forming residues; other site 266779005603 trimer interface [polypeptide binding]; other site 266779005604 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266779005605 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266779005606 short chain dehydrogenase; Provisional; Region: PRK06701 266779005607 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 266779005608 NAD binding site [chemical binding]; other site 266779005609 metal binding site [ion binding]; metal-binding site 266779005610 active site 266779005611 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 266779005612 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 266779005613 active site 266779005614 homotetramer interface [polypeptide binding]; other site 266779005615 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 266779005616 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 266779005617 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266779005618 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 266779005619 active site 266779005620 motif I; other site 266779005621 motif II; other site 266779005622 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 266779005623 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 266779005624 oligomer interface [polypeptide binding]; other site 266779005625 active site residues [active] 266779005626 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266779005627 putative hydrophobic ligand binding site [chemical binding]; other site 266779005628 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779005629 dimerization interface [polypeptide binding]; other site 266779005630 putative DNA binding site [nucleotide binding]; other site 266779005631 putative Zn2+ binding site [ion binding]; other site 266779005632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779005633 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266779005634 putative substrate translocation pore; other site 266779005635 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 266779005636 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266779005637 active site 266779005638 HIGH motif; other site 266779005639 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266779005640 active site 266779005641 KMSKS motif; other site 266779005642 malic enzyme; Reviewed; Region: PRK12862 266779005643 Malic enzyme, N-terminal domain; Region: malic; pfam00390 266779005644 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 266779005645 putative NAD(P) binding site [chemical binding]; other site 266779005646 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 266779005647 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 266779005648 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266779005649 putative NAD(P) binding site [chemical binding]; other site 266779005650 putative active site [active] 266779005651 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 266779005652 putative active site [active] 266779005653 putative metal binding site [ion binding]; other site 266779005654 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 266779005655 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 266779005656 active site 266779005657 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 266779005658 anti sigma factor interaction site; other site 266779005659 regulatory phosphorylation site [posttranslational modification]; other site 266779005660 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 266779005661 Permease; Region: Permease; pfam02405 266779005662 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 266779005663 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779005664 Walker A/P-loop; other site 266779005665 ATP binding site [chemical binding]; other site 266779005666 Q-loop/lid; other site 266779005667 ABC transporter signature motif; other site 266779005668 Walker B; other site 266779005669 D-loop; other site 266779005670 H-loop/switch region; other site 266779005671 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 266779005672 mce related protein; Region: MCE; pfam02470 266779005673 Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1; Region: Peptidase_C12; cl08306 266779005674 catalytic site [active] 266779005675 Protein of unknown function (DUF330); Region: DUF330; cl01135 266779005676 glutamine synthetase; Provisional; Region: glnA; PRK09469 266779005677 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266779005678 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266779005679 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 266779005680 Nitrogen regulatory protein P-II; Region: P-II; smart00938 266779005681 Uncharacterized conserved protein [Function unknown]; Region: COG0062 266779005682 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 266779005683 putative substrate binding site [chemical binding]; other site 266779005684 putative ATP binding site [chemical binding]; other site 266779005685 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266779005686 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266779005687 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 266779005688 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 266779005689 FMN binding site [chemical binding]; other site 266779005690 active site 266779005691 catalytic residues [active] 266779005692 substrate binding site [chemical binding]; other site 266779005693 Predicted aspartyl protease [General function prediction only]; Region: COG3577 266779005694 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 266779005695 catalytic motif [active] 266779005696 Catalytic residue [active] 266779005697 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 266779005698 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 266779005699 putative dimer interface [polypeptide binding]; other site 266779005700 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 266779005701 active site pocket [active] 266779005702 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266779005703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779005704 dimer interface [polypeptide binding]; other site 266779005705 phosphorylation site [posttranslational modification] 266779005706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779005707 ATP binding site [chemical binding]; other site 266779005708 Mg2+ binding site [ion binding]; other site 266779005709 G-X-G motif; other site 266779005710 Staphylococcal nuclease homologues; Region: SNc; smart00318 266779005711 Catalytic site; other site 266779005712 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 266779005713 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266779005714 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 266779005715 putative C-terminal domain interface [polypeptide binding]; other site 266779005716 putative GSH binding site (G-site) [chemical binding]; other site 266779005717 putative dimer interface [polypeptide binding]; other site 266779005718 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 266779005719 putative N-terminal domain interface [polypeptide binding]; other site 266779005720 putative dimer interface [polypeptide binding]; other site 266779005721 putative substrate binding pocket (H-site) [chemical binding]; other site 266779005722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 266779005723 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266779005724 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266779005725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 266779005726 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 266779005727 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266779005728 FeS/SAM binding site; other site 266779005729 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 266779005730 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266779005731 EamA-like transporter family; Region: EamA; cl17759 266779005732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779005733 putative substrate translocation pore; other site 266779005734 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 266779005735 Walker A motif; other site 266779005736 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266779005737 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266779005738 substrate binding pocket [chemical binding]; other site 266779005739 membrane-bound complex binding site; other site 266779005740 hinge residues; other site 266779005741 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266779005742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779005743 dimer interface [polypeptide binding]; other site 266779005744 conserved gate region; other site 266779005745 putative PBP binding loops; other site 266779005746 ABC-ATPase subunit interface; other site 266779005747 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266779005748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779005749 dimer interface [polypeptide binding]; other site 266779005750 conserved gate region; other site 266779005751 putative PBP binding loops; other site 266779005752 ABC-ATPase subunit interface; other site 266779005753 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266779005754 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266779005755 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266779005756 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779005757 putative DNA binding site [nucleotide binding]; other site 266779005758 putative Zn2+ binding site [ion binding]; other site 266779005759 AsnC family; Region: AsnC_trans_reg; pfam01037 266779005760 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 266779005761 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 266779005762 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266779005763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779005764 S-adenosylmethionine binding site [chemical binding]; other site 266779005765 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 266779005766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827 266779005767 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 266779005768 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 266779005769 HIGH motif; other site 266779005770 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 266779005771 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 266779005772 active site 266779005773 KMSKS motif; other site 266779005774 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 266779005775 tRNA binding surface [nucleotide binding]; other site 266779005776 anticodon binding site; other site 266779005777 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 266779005778 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 266779005779 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 266779005780 Uncharacterized conserved protein [Function unknown]; Region: COG2433 266779005781 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 266779005782 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 266779005783 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 266779005784 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 266779005785 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 266779005786 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 266779005787 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 266779005788 thymidylate kinase; Validated; Region: tmk; PRK00698 266779005789 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 266779005790 TMP-binding site; other site 266779005791 ATP-binding site [chemical binding]; other site 266779005792 DNA polymerase III subunit delta'; Validated; Region: PRK09112 266779005793 DNA polymerase III subunit delta'; Validated; Region: PRK08485 266779005794 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 266779005795 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 266779005796 active site 266779005797 HIGH motif; other site 266779005798 KMSKS motif; other site 266779005799 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 266779005800 tRNA binding surface [nucleotide binding]; other site 266779005801 anticodon binding site; other site 266779005802 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 266779005803 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 266779005804 active site 266779005805 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 266779005806 putative hydrolase; Provisional; Region: PRK02113 266779005807 malonyl-CoA synthase; Validated; Region: PRK07514 266779005808 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 266779005809 acyl-activating enzyme (AAE) consensus motif; other site 266779005810 active site 266779005811 AMP binding site [chemical binding]; other site 266779005812 CoA binding site [chemical binding]; other site 266779005813 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 266779005814 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 266779005815 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 266779005816 Cytochrome c; Region: Cytochrom_C; cl11414 266779005817 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266779005818 Cytochrome c553 [Energy production and conversion]; Region: COG2863 266779005819 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266779005820 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 266779005821 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266779005822 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 266779005823 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 266779005824 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266779005825 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 266779005826 Walker A/P-loop; other site 266779005827 ATP binding site [chemical binding]; other site 266779005828 Q-loop/lid; other site 266779005829 ABC transporter signature motif; other site 266779005830 Walker B; other site 266779005831 D-loop; other site 266779005832 H-loop/switch region; other site 266779005833 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266779005834 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 266779005835 Walker A/P-loop; other site 266779005836 ATP binding site [chemical binding]; other site 266779005837 Q-loop/lid; other site 266779005838 ABC transporter signature motif; other site 266779005839 Walker B; other site 266779005840 D-loop; other site 266779005841 H-loop/switch region; other site 266779005842 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 266779005843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779005844 dimer interface [polypeptide binding]; other site 266779005845 conserved gate region; other site 266779005846 putative PBP binding loops; other site 266779005847 ABC-ATPase subunit interface; other site 266779005848 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266779005849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779005850 dimer interface [polypeptide binding]; other site 266779005851 conserved gate region; other site 266779005852 ABC-ATPase subunit interface; other site 266779005853 Predicted small integral membrane protein [Function unknown]; Region: COG5477 266779005854 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266779005855 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 266779005856 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 266779005857 N- and C-terminal domain interface [polypeptide binding]; other site 266779005858 active site 266779005859 MgATP binding site [chemical binding]; other site 266779005860 catalytic site [active] 266779005861 metal binding site [ion binding]; metal-binding site 266779005862 glycerol binding site [chemical binding]; other site 266779005863 homotetramer interface [polypeptide binding]; other site 266779005864 homodimer interface [polypeptide binding]; other site 266779005865 FBP binding site [chemical binding]; other site 266779005866 protein IIAGlc interface [polypeptide binding]; other site 266779005867 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266779005868 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 266779005869 conserved cys residue [active] 266779005870 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779005871 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266779005872 Methyltransferase domain; Region: Methyltransf_18; pfam12847 266779005873 S-adenosylmethionine binding site [chemical binding]; other site 266779005874 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 266779005875 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 266779005876 active site 266779005877 catalytic residues [active] 266779005878 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266779005879 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266779005880 Bacterial transcriptional regulator; Region: IclR; pfam01614 266779005881 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 266779005882 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266779005883 ligand binding site [chemical binding]; other site 266779005884 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266779005885 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266779005886 TM-ABC transporter signature motif; other site 266779005887 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266779005888 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266779005889 TM-ABC transporter signature motif; other site 266779005890 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266779005891 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266779005892 Walker A/P-loop; other site 266779005893 ATP binding site [chemical binding]; other site 266779005894 Q-loop/lid; other site 266779005895 ABC transporter signature motif; other site 266779005896 Walker B; other site 266779005897 D-loop; other site 266779005898 H-loop/switch region; other site 266779005899 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266779005900 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266779005901 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266779005902 active site 266779005903 catalytic tetrad [active] 266779005904 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266779005905 Amidohydrolase; Region: Amidohydro_2; pfam04909 266779005906 active site 266779005907 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 266779005908 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 266779005909 homodimer interface [polypeptide binding]; other site 266779005910 metal binding site [ion binding]; metal-binding site 266779005911 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 266779005912 homodimer interface [polypeptide binding]; other site 266779005913 active site 266779005914 putative chemical substrate binding site [chemical binding]; other site 266779005915 metal binding site [ion binding]; metal-binding site 266779005916 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 266779005917 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 266779005918 HflX GTPase family; Region: HflX; cd01878 266779005919 G1 box; other site 266779005920 GTP/Mg2+ binding site [chemical binding]; other site 266779005921 Switch I region; other site 266779005922 G2 box; other site 266779005923 G3 box; other site 266779005924 Switch II region; other site 266779005925 G4 box; other site 266779005926 G5 box; other site 266779005927 bacterial Hfq-like; Region: Hfq; cd01716 266779005928 hexamer interface [polypeptide binding]; other site 266779005929 Sm1 motif; other site 266779005930 RNA binding site [nucleotide binding]; other site 266779005931 Sm2 motif; other site 266779005932 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266779005933 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 266779005934 homodimer interface [polypeptide binding]; other site 266779005935 substrate-cofactor binding pocket; other site 266779005936 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779005937 catalytic residue [active] 266779005938 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 266779005939 TrkA-N domain; Region: TrkA_N; pfam02254 266779005940 TrkA-C domain; Region: TrkA_C; pfam02080 266779005941 TrkA-N domain; Region: TrkA_N; pfam02254 266779005942 TrkA-C domain; Region: TrkA_C; pfam02080 266779005943 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266779005944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779005945 active site 266779005946 phosphorylation site [posttranslational modification] 266779005947 intermolecular recognition site; other site 266779005948 dimerization interface [polypeptide binding]; other site 266779005949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779005950 Walker A motif; other site 266779005951 ATP binding site [chemical binding]; other site 266779005952 Walker B motif; other site 266779005953 arginine finger; other site 266779005954 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266779005955 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 266779005956 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266779005957 dimerization interface [polypeptide binding]; other site 266779005958 PAS domain; Region: PAS; smart00091 266779005959 putative active site [active] 266779005960 heme pocket [chemical binding]; other site 266779005961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779005962 dimer interface [polypeptide binding]; other site 266779005963 phosphorylation site [posttranslational modification] 266779005964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779005965 ATP binding site [chemical binding]; other site 266779005966 Mg2+ binding site [ion binding]; other site 266779005967 G-X-G motif; other site 266779005968 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 266779005969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779005970 active site 266779005971 phosphorylation site [posttranslational modification] 266779005972 intermolecular recognition site; other site 266779005973 dimerization interface [polypeptide binding]; other site 266779005974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779005975 Walker A motif; other site 266779005976 ATP binding site [chemical binding]; other site 266779005977 Walker B motif; other site 266779005978 arginine finger; other site 266779005979 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 266779005980 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266779005981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779005982 dimer interface [polypeptide binding]; other site 266779005983 phosphorylation site [posttranslational modification] 266779005984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779005985 ATP binding site [chemical binding]; other site 266779005986 Mg2+ binding site [ion binding]; other site 266779005987 G-X-G motif; other site 266779005988 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 266779005989 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 266779005990 FMN binding site [chemical binding]; other site 266779005991 active site 266779005992 catalytic residues [active] 266779005993 substrate binding site [chemical binding]; other site 266779005994 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 266779005995 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 266779005996 substrate binding site; other site 266779005997 dimer interface; other site 266779005998 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 266779005999 homotrimer interaction site [polypeptide binding]; other site 266779006000 zinc binding site [ion binding]; other site 266779006001 CDP-binding sites; other site 266779006002 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 266779006003 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 266779006004 putative coenzyme Q binding site [chemical binding]; other site 266779006005 lipoyl synthase; Provisional; Region: PRK05481 266779006006 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266779006007 FeS/SAM binding site; other site 266779006008 Predicted membrane protein [Function unknown]; Region: COG2261 266779006009 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 266779006010 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 266779006011 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266779006012 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266779006013 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 266779006014 active site 266779006015 catalytic triad [active] 266779006016 oxyanion hole [active] 266779006017 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266779006018 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 266779006019 E3 interaction surface; other site 266779006020 lipoyl attachment site [posttranslational modification]; other site 266779006021 e3 binding domain; Region: E3_binding; pfam02817 266779006022 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 266779006023 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 266779006024 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266779006025 E3 interaction surface; other site 266779006026 lipoyl attachment site [posttranslational modification]; other site 266779006027 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 266779006028 alpha subunit interface [polypeptide binding]; other site 266779006029 TPP binding site [chemical binding]; other site 266779006030 heterodimer interface [polypeptide binding]; other site 266779006031 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266779006032 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 266779006033 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 266779006034 tetramer interface [polypeptide binding]; other site 266779006035 TPP-binding site [chemical binding]; other site 266779006036 heterodimer interface [polypeptide binding]; other site 266779006037 phosphorylation loop region [posttranslational modification] 266779006038 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 266779006039 Septum formation initiator; Region: DivIC; pfam04977 266779006040 enolase; Provisional; Region: eno; PRK00077 266779006041 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 266779006042 dimer interface [polypeptide binding]; other site 266779006043 metal binding site [ion binding]; metal-binding site 266779006044 substrate binding pocket [chemical binding]; other site 266779006045 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 266779006046 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 266779006047 CTP synthetase; Validated; Region: pyrG; PRK05380 266779006048 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 266779006049 Catalytic site [active] 266779006050 active site 266779006051 UTP binding site [chemical binding]; other site 266779006052 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 266779006053 active site 266779006054 putative oxyanion hole; other site 266779006055 catalytic triad [active] 266779006056 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 266779006057 triosephosphate isomerase; Provisional; Region: PRK14565 266779006058 substrate binding site [chemical binding]; other site 266779006059 dimer interface [polypeptide binding]; other site 266779006060 catalytic triad [active] 266779006061 periplasmic folding chaperone; Provisional; Region: PRK10788 266779006062 SurA N-terminal domain; Region: SurA_N_3; cl07813 266779006063 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 266779006064 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 266779006065 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 266779006066 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 266779006067 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 266779006068 active site 266779006069 ribulose/triose binding site [chemical binding]; other site 266779006070 phosphate binding site [ion binding]; other site 266779006071 substrate (anthranilate) binding pocket [chemical binding]; other site 266779006072 product (indole) binding pocket [chemical binding]; other site 266779006073 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 266779006074 trimer interface [polypeptide binding]; other site 266779006075 dimer interface [polypeptide binding]; other site 266779006076 putative active site [active] 266779006077 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 266779006078 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 266779006079 dimer interface [polypeptide binding]; other site 266779006080 putative functional site; other site 266779006081 putative MPT binding site; other site 266779006082 LexA repressor; Validated; Region: PRK00215 266779006083 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 266779006084 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 266779006085 Catalytic site [active] 266779006086 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266779006087 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 266779006088 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 266779006089 Competence protein; Region: Competence; pfam03772 266779006090 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 266779006091 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266779006092 active site 266779006093 HIGH motif; other site 266779006094 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266779006095 active site 266779006096 KMSKS motif; other site 266779006097 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 266779006098 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 266779006099 dimer interface [polypeptide binding]; other site 266779006100 active site 266779006101 citrylCoA binding site [chemical binding]; other site 266779006102 NADH binding [chemical binding]; other site 266779006103 cationic pore residues; other site 266779006104 oxalacetate/citrate binding site [chemical binding]; other site 266779006105 coenzyme A binding site [chemical binding]; other site 266779006106 catalytic triad [active] 266779006107 ATP12 chaperone protein; Region: ATP12; cl02228 266779006108 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 266779006109 S4 RNA-binding domain; Region: S4; smart00363 266779006110 RNA binding surface [nucleotide binding]; other site 266779006111 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 266779006112 active site 266779006113 camphor resistance protein CrcB; Provisional; Region: PRK14195 266779006114 recombination factor protein RarA; Reviewed; Region: PRK13342 266779006115 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779006116 Walker A motif; other site 266779006117 ATP binding site [chemical binding]; other site 266779006118 Walker B motif; other site 266779006119 arginine finger; other site 266779006120 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 266779006121 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 266779006122 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266779006123 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266779006124 protein binding site [polypeptide binding]; other site 266779006125 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266779006126 protein binding site [polypeptide binding]; other site 266779006127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3169 266779006128 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 266779006129 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 266779006130 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 266779006131 alphaNTD homodimer interface [polypeptide binding]; other site 266779006132 alphaNTD - beta interaction site [polypeptide binding]; other site 266779006133 alphaNTD - beta' interaction site [polypeptide binding]; other site 266779006134 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 266779006135 30S ribosomal protein S11; Validated; Region: PRK05309 266779006136 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 266779006137 30S ribosomal protein S13; Region: bact_S13; TIGR03631 266779006138 adenylate kinase; Reviewed; Region: adk; PRK00279 266779006139 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 266779006140 AMP-binding site [chemical binding]; other site 266779006141 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 266779006142 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 266779006143 SecY translocase; Region: SecY; pfam00344 266779006144 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 266779006145 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 266779006146 23S rRNA binding site [nucleotide binding]; other site 266779006147 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 266779006148 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 266779006149 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 266779006150 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 266779006151 23S rRNA interface [nucleotide binding]; other site 266779006152 L21e interface [polypeptide binding]; other site 266779006153 5S rRNA interface [nucleotide binding]; other site 266779006154 L27 interface [polypeptide binding]; other site 266779006155 L5 interface [polypeptide binding]; other site 266779006156 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 266779006157 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 266779006158 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 266779006159 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 266779006160 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 266779006161 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 266779006162 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 266779006163 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 266779006164 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 266779006165 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 266779006166 RNA binding site [nucleotide binding]; other site 266779006167 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 266779006168 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 266779006169 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 266779006170 23S rRNA interface [nucleotide binding]; other site 266779006171 putative translocon interaction site; other site 266779006172 signal recognition particle (SRP54) interaction site; other site 266779006173 L23 interface [polypeptide binding]; other site 266779006174 trigger factor interaction site; other site 266779006175 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 266779006176 23S rRNA interface [nucleotide binding]; other site 266779006177 5S rRNA interface [nucleotide binding]; other site 266779006178 putative antibiotic binding site [chemical binding]; other site 266779006179 L25 interface [polypeptide binding]; other site 266779006180 L27 interface [polypeptide binding]; other site 266779006181 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 266779006182 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 266779006183 G-X-X-G motif; other site 266779006184 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 266779006185 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 266779006186 putative translocon binding site; other site 266779006187 protein-rRNA interface [nucleotide binding]; other site 266779006188 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 266779006189 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 266779006190 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 266779006191 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 266779006192 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 266779006193 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 266779006194 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 266779006195 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 266779006196 elongation factor Tu; Reviewed; Region: PRK00049 266779006197 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 266779006198 G1 box; other site 266779006199 GEF interaction site [polypeptide binding]; other site 266779006200 GTP/Mg2+ binding site [chemical binding]; other site 266779006201 Switch I region; other site 266779006202 G2 box; other site 266779006203 G3 box; other site 266779006204 Switch II region; other site 266779006205 G4 box; other site 266779006206 G5 box; other site 266779006207 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 266779006208 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 266779006209 Antibiotic Binding Site [chemical binding]; other site 266779006210 elongation factor G; Reviewed; Region: PRK00007 266779006211 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 266779006212 G1 box; other site 266779006213 putative GEF interaction site [polypeptide binding]; other site 266779006214 GTP/Mg2+ binding site [chemical binding]; other site 266779006215 Switch I region; other site 266779006216 G2 box; other site 266779006217 G3 box; other site 266779006218 Switch II region; other site 266779006219 G4 box; other site 266779006220 G5 box; other site 266779006221 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 266779006222 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 266779006223 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 266779006224 30S ribosomal protein S7; Validated; Region: PRK05302 266779006225 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 266779006226 S17 interaction site [polypeptide binding]; other site 266779006227 S8 interaction site; other site 266779006228 16S rRNA interaction site [nucleotide binding]; other site 266779006229 streptomycin interaction site [chemical binding]; other site 266779006230 23S rRNA interaction site [nucleotide binding]; other site 266779006231 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 266779006232 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 266779006233 putative catalytic site [active] 266779006234 putative phosphate binding site [ion binding]; other site 266779006235 active site 266779006236 metal binding site A [ion binding]; metal-binding site 266779006237 DNA binding site [nucleotide binding] 266779006238 putative AP binding site [nucleotide binding]; other site 266779006239 putative metal binding site B [ion binding]; other site 266779006240 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266779006241 Sel1-like repeats; Region: SEL1; smart00671 266779006242 Sel1-like repeats; Region: SEL1; smart00671 266779006243 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 266779006244 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266779006245 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 266779006246 putative C-terminal domain interface [polypeptide binding]; other site 266779006247 putative GSH binding site (G-site) [chemical binding]; other site 266779006248 putative dimer interface [polypeptide binding]; other site 266779006249 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 266779006250 N-terminal domain interface [polypeptide binding]; other site 266779006251 dimer interface [polypeptide binding]; other site 266779006252 substrate binding pocket (H-site) [chemical binding]; other site 266779006253 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 266779006254 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 266779006255 putative ligand binding site [chemical binding]; other site 266779006256 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266779006257 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266779006258 TM-ABC transporter signature motif; other site 266779006259 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266779006260 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266779006261 TM-ABC transporter signature motif; other site 266779006262 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266779006263 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266779006264 Walker A/P-loop; other site 266779006265 ATP binding site [chemical binding]; other site 266779006266 Q-loop/lid; other site 266779006267 ABC transporter signature motif; other site 266779006268 Walker B; other site 266779006269 D-loop; other site 266779006270 H-loop/switch region; other site 266779006271 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266779006272 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 266779006273 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 266779006274 NADP binding site [chemical binding]; other site 266779006275 dimer interface [polypeptide binding]; other site 266779006276 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 266779006277 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 266779006278 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 266779006279 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266779006280 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 266779006281 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 266779006282 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 266779006283 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 266779006284 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 266779006285 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 266779006286 catalytic residues [active] 266779006287 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 266779006288 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 266779006289 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 266779006290 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266779006291 ATP binding site [chemical binding]; other site 266779006292 putative Mg++ binding site [ion binding]; other site 266779006293 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266779006294 nucleotide binding region [chemical binding]; other site 266779006295 ATP-binding site [chemical binding]; other site 266779006296 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 266779006297 Uncharacterized conserved protein [Function unknown]; Region: COG2938 266779006298 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 266779006299 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 266779006300 generic binding surface II; other site 266779006301 ssDNA binding site; other site 266779006302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266779006303 ATP binding site [chemical binding]; other site 266779006304 putative Mg++ binding site [ion binding]; other site 266779006305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266779006306 nucleotide binding region [chemical binding]; other site 266779006307 ATP-binding site [chemical binding]; other site 266779006308 Uncharacterized conserved protein [Function unknown]; Region: COG2928 266779006309 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 266779006310 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 266779006311 glutaminase active site [active] 266779006312 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 266779006313 dimer interface [polypeptide binding]; other site 266779006314 active site 266779006315 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266779006316 dimer interface [polypeptide binding]; other site 266779006317 active site 266779006318 peptide chain release factor 2; Provisional; Region: PRK07342 266779006319 This domain is found in peptide chain release factors; Region: PCRF; smart00937 266779006320 RF-1 domain; Region: RF-1; pfam00472 266779006321 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 266779006322 Transglycosylase; Region: Transgly; pfam00912 266779006323 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266779006324 AMIN domain; Region: AMIN; pfam11741 266779006325 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 266779006326 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 266779006327 active site 266779006328 metal binding site [ion binding]; metal-binding site 266779006329 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 266779006330 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 266779006331 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 266779006332 Peptidase family M48; Region: Peptidase_M48; cl12018 266779006333 TPR repeat; Region: TPR_11; pfam13414 266779006334 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266779006335 TPR motif; other site 266779006336 binding surface 266779006337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266779006338 TPR motif; other site 266779006339 binding surface 266779006340 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 266779006341 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 266779006342 catalytic residues [active] 266779006343 Dehydroquinase class II; Region: DHquinase_II; pfam01220 266779006344 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 266779006345 trimer interface [polypeptide binding]; other site 266779006346 active site 266779006347 dimer interface [polypeptide binding]; other site 266779006348 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 266779006349 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266779006350 carboxyltransferase (CT) interaction site; other site 266779006351 biotinylation site [posttranslational modification]; other site 266779006352 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 266779006353 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266779006354 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 266779006355 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266779006356 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 266779006357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 266779006358 NADH dehydrogenase; Validated; Region: PRK08183 266779006359 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 266779006360 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 266779006361 GatB domain; Region: GatB_Yqey; smart00845 266779006362 Uncharacterized protein conserved in bacteria (DUF2084); Region: DUF2084; pfam09857 266779006363 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 266779006364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 266779006365 PAS domain; Region: PAS_5; pfam07310 266779006366 PilZ domain; Region: PilZ; pfam07238 266779006367 PilZ domain; Region: PilZ; pfam07238 266779006368 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 266779006369 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 266779006370 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 266779006371 trimer interface [polypeptide binding]; other site 266779006372 putative metal binding site [ion binding]; other site 266779006373 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 266779006374 serine acetyltransferase; Provisional; Region: cysE; PRK11132 266779006375 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 266779006376 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 266779006377 trimer interface [polypeptide binding]; other site 266779006378 active site 266779006379 substrate binding site [chemical binding]; other site 266779006380 CoA binding site [chemical binding]; other site 266779006381 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 266779006382 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266779006383 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266779006384 Uncharacterized conserved protein [Function unknown]; Region: COG1430 266779006385 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266779006386 DNA-binding site [nucleotide binding]; DNA binding site 266779006387 RNA-binding motif; other site 266779006388 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266779006389 DNA-binding site [nucleotide binding]; DNA binding site 266779006390 RNA-binding motif; other site 266779006391 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266779006392 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 266779006393 dimer interface [polypeptide binding]; other site 266779006394 active site 266779006395 metal binding site [ion binding]; metal-binding site 266779006396 glutathione binding site [chemical binding]; other site 266779006397 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 266779006398 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 266779006399 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 266779006400 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 266779006401 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 266779006402 active site 266779006403 PAS domain; Region: PAS; smart00091 266779006404 PAS domain; Region: PAS_9; pfam13426 266779006405 putative active site [active] 266779006406 heme pocket [chemical binding]; other site 266779006407 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 266779006408 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266779006409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779006410 dimer interface [polypeptide binding]; other site 266779006411 phosphorylation site [posttranslational modification] 266779006412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779006413 ATP binding site [chemical binding]; other site 266779006414 Mg2+ binding site [ion binding]; other site 266779006415 G-X-G motif; other site 266779006416 Response regulator receiver domain; Region: Response_reg; pfam00072 266779006417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779006418 active site 266779006419 phosphorylation site [posttranslational modification] 266779006420 intermolecular recognition site; other site 266779006421 dimerization interface [polypeptide binding]; other site 266779006422 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266779006423 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266779006424 metal binding site [ion binding]; metal-binding site 266779006425 active site 266779006426 I-site; other site 266779006427 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 266779006428 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 266779006429 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 266779006430 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266779006431 motif II; other site 266779006432 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266779006433 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266779006434 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 266779006435 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266779006436 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266779006437 protein binding site [polypeptide binding]; other site 266779006438 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 266779006439 protein binding site [polypeptide binding]; other site 266779006440 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 266779006441 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 266779006442 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 266779006443 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 266779006444 HflK protein; Region: hflK; TIGR01933 266779006445 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 266779006446 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 266779006447 folate binding site [chemical binding]; other site 266779006448 NADP+ binding site [chemical binding]; other site 266779006449 thymidylate synthase; Reviewed; Region: thyA; PRK01827 266779006450 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 266779006451 dimerization interface [polypeptide binding]; other site 266779006452 active site 266779006453 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 266779006454 Predicted ATPase [General function prediction only]; Region: COG3911 266779006455 AAA domain; Region: AAA_28; pfam13521 266779006456 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 266779006457 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266779006458 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266779006459 ABC transporter; Region: ABC_tran_2; pfam12848 266779006460 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266779006461 DNA polymerase III subunit chi; Validated; Region: PRK05728 266779006462 multifunctional aminopeptidase A; Provisional; Region: PRK00913 266779006463 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 266779006464 interface (dimer of trimers) [polypeptide binding]; other site 266779006465 Substrate-binding/catalytic site; other site 266779006466 Zn-binding sites [ion binding]; other site 266779006467 Predicted permeases [General function prediction only]; Region: COG0795 266779006468 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 266779006469 Predicted permeases [General function prediction only]; Region: COG0795 266779006470 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 266779006471 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 266779006472 Organic solvent tolerance protein; Region: OstA_C; pfam04453 266779006473 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 266779006474 SurA N-terminal domain; Region: SurA_N; pfam09312 266779006475 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 266779006476 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 266779006477 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 266779006478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779006479 S-adenosylmethionine binding site [chemical binding]; other site 266779006480 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 266779006481 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 266779006482 catalytic site [active] 266779006483 G-X2-G-X-G-K; other site 266779006484 hypothetical protein; Provisional; Region: PRK11820 266779006485 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 266779006486 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 266779006487 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 266779006488 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 266779006489 dimerization interface [polypeptide binding]; other site 266779006490 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 266779006491 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266779006492 dimer interface [polypeptide binding]; other site 266779006493 active site 266779006494 acyl carrier protein; Provisional; Region: acpP; PRK00982 266779006495 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 266779006496 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266779006497 NAD(P) binding site [chemical binding]; other site 266779006498 homotetramer interface [polypeptide binding]; other site 266779006499 homodimer interface [polypeptide binding]; other site 266779006500 active site 266779006501 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 266779006502 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 266779006503 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 266779006504 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 266779006505 Substrate binding site; other site 266779006506 Mg++ binding site; other site 266779006507 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 266779006508 active site 266779006509 substrate binding site [chemical binding]; other site 266779006510 CoA binding site [chemical binding]; other site 266779006511 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 266779006512 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 266779006513 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 266779006514 ATP-NAD kinase; Region: NAD_kinase; pfam01513 266779006515 helicase 45; Provisional; Region: PTZ00424 266779006516 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266779006517 ATP binding site [chemical binding]; other site 266779006518 Mg++ binding site [ion binding]; other site 266779006519 motif III; other site 266779006520 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266779006521 nucleotide binding region [chemical binding]; other site 266779006522 ATP-binding site [chemical binding]; other site 266779006523 TfoX N-terminal domain; Region: TfoX_N; pfam04993 266779006524 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266779006525 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 266779006526 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 266779006527 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266779006528 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 266779006529 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266779006530 catalytic residue [active] 266779006531 FeS assembly protein SufD; Region: sufD; TIGR01981 266779006532 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 266779006533 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 266779006534 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 266779006535 Walker A/P-loop; other site 266779006536 ATP binding site [chemical binding]; other site 266779006537 Q-loop/lid; other site 266779006538 ABC transporter signature motif; other site 266779006539 Walker B; other site 266779006540 D-loop; other site 266779006541 H-loop/switch region; other site 266779006542 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 266779006543 putative ABC transporter; Region: ycf24; CHL00085 266779006544 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 266779006545 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 266779006546 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266779006547 catalytic residue [active] 266779006548 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 266779006549 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266779006550 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 266779006551 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 266779006552 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 266779006553 active site 266779006554 HIGH motif; other site 266779006555 dimer interface [polypeptide binding]; other site 266779006556 KMSKS motif; other site 266779006557 Protein of unknown function; Region: DUF3971; pfam13116 266779006558 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266779006559 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 266779006560 catalytic triad [active] 266779006561 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 266779006562 Peptidase family M23; Region: Peptidase_M23; pfam01551 266779006563 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 266779006564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779006565 putative substrate translocation pore; other site 266779006566 trigger factor; Provisional; Region: tig; PRK01490 266779006567 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 266779006568 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 266779006569 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 266779006570 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 266779006571 Glucose inhibited division protein A; Region: GIDA; pfam01134 266779006572 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 266779006573 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 266779006574 substrate binding pocket [chemical binding]; other site 266779006575 substrate-Mg2+ binding site; other site 266779006576 aspartate-rich region 2; other site 266779006577 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 266779006578 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 266779006579 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 266779006580 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 266779006581 Protein export membrane protein; Region: SecD_SecF; pfam02355 266779006582 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 266779006583 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 266779006584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779006585 Walker A motif; other site 266779006586 ATP binding site [chemical binding]; other site 266779006587 Walker B motif; other site 266779006588 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266779006589 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 266779006590 Peptidase family M23; Region: Peptidase_M23; pfam01551 266779006591 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 266779006592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779006593 S-adenosylmethionine binding site [chemical binding]; other site 266779006594 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 266779006595 seryl-tRNA synthetase; Provisional; Region: PRK05431 266779006596 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 266779006597 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 266779006598 dimer interface [polypeptide binding]; other site 266779006599 active site 266779006600 motif 1; other site 266779006601 motif 2; other site 266779006602 motif 3; other site 266779006603 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 266779006604 sec-independent translocase; Provisional; Region: PRK00708 266779006605 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 266779006606 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 266779006607 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266779006608 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 266779006609 Walker A/P-loop; other site 266779006610 ATP binding site [chemical binding]; other site 266779006611 Q-loop/lid; other site 266779006612 ABC transporter signature motif; other site 266779006613 Walker B; other site 266779006614 D-loop; other site 266779006615 H-loop/switch region; other site 266779006616 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 266779006617 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 266779006618 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 266779006619 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 266779006620 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266779006621 Beta-lactamase; Region: Beta-lactamase; pfam00144 266779006622 Sporulation related domain; Region: SPOR; pfam05036 266779006623 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 266779006624 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 266779006625 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 266779006626 active site 266779006627 HIGH motif; other site 266779006628 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266779006629 KMSK motif region; other site 266779006630 tRNA binding surface [nucleotide binding]; other site 266779006631 DALR anticodon binding domain; Region: DALR_1; smart00836 266779006632 anticodon binding site; other site 266779006633 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 266779006634 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266779006635 Zn2+ binding site [ion binding]; other site 266779006636 Mg2+ binding site [ion binding]; other site 266779006637 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 266779006638 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 266779006639 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 266779006640 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 266779006641 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 266779006642 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 266779006643 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 266779006644 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 266779006645 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 266779006646 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 266779006647 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 266779006648 DNA binding site [nucleotide binding] 266779006649 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 266779006650 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 266779006651 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 266779006652 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 266779006653 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 266779006654 RPB11 interaction site [polypeptide binding]; other site 266779006655 RPB12 interaction site [polypeptide binding]; other site 266779006656 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 266779006657 RPB1 interaction site [polypeptide binding]; other site 266779006658 RPB11 interaction site [polypeptide binding]; other site 266779006659 RPB10 interaction site [polypeptide binding]; other site 266779006660 RPB3 interaction site [polypeptide binding]; other site 266779006661 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 266779006662 core dimer interface [polypeptide binding]; other site 266779006663 peripheral dimer interface [polypeptide binding]; other site 266779006664 L10 interface [polypeptide binding]; other site 266779006665 L11 interface [polypeptide binding]; other site 266779006666 putative EF-Tu interaction site [polypeptide binding]; other site 266779006667 putative EF-G interaction site [polypeptide binding]; other site 266779006668 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 266779006669 23S rRNA interface [nucleotide binding]; other site 266779006670 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 266779006671 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 266779006672 mRNA/rRNA interface [nucleotide binding]; other site 266779006673 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 266779006674 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 266779006675 23S rRNA interface [nucleotide binding]; other site 266779006676 L7/L12 interface [polypeptide binding]; other site 266779006677 putative thiostrepton binding site; other site 266779006678 L25 interface [polypeptide binding]; other site 266779006679 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 266779006680 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 266779006681 putative homodimer interface [polypeptide binding]; other site 266779006682 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 266779006683 heterodimer interface [polypeptide binding]; other site 266779006684 homodimer interface [polypeptide binding]; other site 266779006685 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 266779006686 elongation factor Tu; Reviewed; Region: PRK00049 266779006687 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 266779006688 G1 box; other site 266779006689 GEF interaction site [polypeptide binding]; other site 266779006690 GTP/Mg2+ binding site [chemical binding]; other site 266779006691 Switch I region; other site 266779006692 G2 box; other site 266779006693 G3 box; other site 266779006694 Switch II region; other site 266779006695 G4 box; other site 266779006696 G5 box; other site 266779006697 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 266779006698 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 266779006699 Antibiotic Binding Site [chemical binding]; other site 266779006700 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 266779006701 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 266779006702 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266779006703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779006704 DNA-binding site [nucleotide binding]; DNA binding site 266779006705 FCD domain; Region: FCD; pfam07729 266779006706 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 266779006707 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266779006708 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266779006709 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266779006710 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266779006711 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266779006712 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779006713 Walker A/P-loop; other site 266779006714 ATP binding site [chemical binding]; other site 266779006715 Q-loop/lid; other site 266779006716 ABC transporter signature motif; other site 266779006717 Walker B; other site 266779006718 D-loop; other site 266779006719 H-loop/switch region; other site 266779006720 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779006721 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779006722 Walker A/P-loop; other site 266779006723 ATP binding site [chemical binding]; other site 266779006724 Q-loop/lid; other site 266779006725 ABC transporter signature motif; other site 266779006726 Walker B; other site 266779006727 D-loop; other site 266779006728 H-loop/switch region; other site 266779006729 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266779006730 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 266779006731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779006732 dimer interface [polypeptide binding]; other site 266779006733 conserved gate region; other site 266779006734 putative PBP binding loops; other site 266779006735 ABC-ATPase subunit interface; other site 266779006736 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779006737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779006738 dimer interface [polypeptide binding]; other site 266779006739 conserved gate region; other site 266779006740 putative PBP binding loops; other site 266779006741 ABC-ATPase subunit interface; other site 266779006742 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 266779006743 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266779006744 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 266779006745 homotrimer interaction site [polypeptide binding]; other site 266779006746 putative active site [active] 266779006747 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 266779006748 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 266779006749 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266779006750 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266779006751 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 266779006752 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 266779006753 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266779006754 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266779006755 Bacterial transcriptional regulator; Region: IclR; pfam01614 266779006756 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 266779006757 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 266779006758 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 266779006759 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266779006760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266779006761 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 266779006762 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 266779006763 active site 266779006764 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 266779006765 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779006766 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 266779006767 putative dimerization interface [polypeptide binding]; other site 266779006768 Protein of unknown function (DUF917); Region: DUF917; pfam06032 266779006769 Protein of unknown function (DUF917); Region: DUF917; pfam06032 266779006770 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266779006771 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266779006772 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266779006773 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 266779006774 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266779006775 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266779006776 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266779006777 active site 266779006778 non-prolyl cis peptide bond; other site 266779006779 AroM protein; Region: AroM; pfam07302 266779006780 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266779006781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266779006782 DNA binding residues [nucleotide binding] 266779006783 dimerization interface [polypeptide binding]; other site 266779006784 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266779006785 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 266779006786 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779006787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779006788 dimer interface [polypeptide binding]; other site 266779006789 conserved gate region; other site 266779006790 putative PBP binding loops; other site 266779006791 ABC-ATPase subunit interface; other site 266779006792 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266779006793 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266779006794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779006795 dimer interface [polypeptide binding]; other site 266779006796 conserved gate region; other site 266779006797 putative PBP binding loops; other site 266779006798 ABC-ATPase subunit interface; other site 266779006799 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266779006800 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779006801 Walker A/P-loop; other site 266779006802 ATP binding site [chemical binding]; other site 266779006803 Q-loop/lid; other site 266779006804 ABC transporter signature motif; other site 266779006805 Walker B; other site 266779006806 D-loop; other site 266779006807 H-loop/switch region; other site 266779006808 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266779006809 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 266779006810 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779006811 Walker A/P-loop; other site 266779006812 ATP binding site [chemical binding]; other site 266779006813 Q-loop/lid; other site 266779006814 ABC transporter signature motif; other site 266779006815 Walker B; other site 266779006816 D-loop; other site 266779006817 H-loop/switch region; other site 266779006818 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266779006819 Creatinine amidohydrolase; Region: Creatininase; pfam02633 266779006820 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 266779006821 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266779006822 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266779006823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779006824 dimer interface [polypeptide binding]; other site 266779006825 conserved gate region; other site 266779006826 putative PBP binding loops; other site 266779006827 ABC-ATPase subunit interface; other site 266779006828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779006829 dimer interface [polypeptide binding]; other site 266779006830 conserved gate region; other site 266779006831 putative PBP binding loops; other site 266779006832 ABC-ATPase subunit interface; other site 266779006833 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266779006834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779006835 Walker A/P-loop; other site 266779006836 ATP binding site [chemical binding]; other site 266779006837 Q-loop/lid; other site 266779006838 ABC transporter signature motif; other site 266779006839 Walker B; other site 266779006840 D-loop; other site 266779006841 H-loop/switch region; other site 266779006842 TOBE domain; Region: TOBE_2; pfam08402 266779006843 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266779006844 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 266779006845 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266779006846 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266779006847 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266779006848 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779006849 DNA-binding site [nucleotide binding]; DNA binding site 266779006850 FCD domain; Region: FCD; pfam07729 266779006851 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 266779006852 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 266779006853 putative active site [active] 266779006854 metal binding site [ion binding]; metal-binding site 266779006855 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 266779006856 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 266779006857 NAD(P) binding site [chemical binding]; other site 266779006858 catalytic residues [active] 266779006859 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 266779006860 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266779006861 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266779006862 N-formylglutamate amidohydrolase; Region: FGase; cl01522 266779006863 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266779006864 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266779006865 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266779006866 putative active site [active] 266779006867 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 266779006868 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 266779006869 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 266779006870 dimanganese center [ion binding]; other site 266779006871 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 266779006872 BA14K-like protein; Region: BA14K; pfam07886 266779006873 BA14K-like protein; Region: BA14K; pfam07886 266779006874 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 266779006875 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 266779006876 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 266779006877 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266779006878 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266779006879 catalytic residue [active] 266779006880 Phage minor tail protein; Region: Phage_min_tail; cl01940 266779006881 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 266779006882 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 266779006883 nucleophile elbow; other site 266779006884 Phage Terminase; Region: Terminase_1; pfam03354 266779006885 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 266779006886 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 266779006887 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 266779006888 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 266779006889 oligomerization interface [polypeptide binding]; other site 266779006890 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266779006891 active site 266779006892 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 266779006893 Phage capsid family; Region: Phage_capsid; pfam05065 266779006894 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 266779006895 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 266779006896 Phage-related protein [Function unknown]; Region: COG4695 266779006897 Phage portal protein; Region: Phage_portal; pfam04860 266779006898 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266779006899 active site 266779006900 DNA binding site [nucleotide binding] 266779006901 Int/Topo IB signature motif; other site 266779006902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266779006903 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 266779006904 putative active site [active] 266779006905 heme pocket [chemical binding]; other site 266779006906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266779006907 putative active site [active] 266779006908 heme pocket [chemical binding]; other site 266779006909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779006910 dimer interface [polypeptide binding]; other site 266779006911 phosphorylation site [posttranslational modification] 266779006912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779006913 ATP binding site [chemical binding]; other site 266779006914 Mg2+ binding site [ion binding]; other site 266779006915 G-X-G motif; other site 266779006916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779006917 active site 266779006918 phosphorylation site [posttranslational modification] 266779006919 intermolecular recognition site; other site 266779006920 dimerization interface [polypeptide binding]; other site 266779006921 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266779006922 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266779006923 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266779006924 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266779006925 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266779006926 catalytic loop [active] 266779006927 iron binding site [ion binding]; other site 266779006928 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266779006929 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266779006930 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266779006931 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266779006932 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266779006933 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266779006934 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 266779006935 ATP binding site [chemical binding]; other site 266779006936 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266779006937 DNA-binding site [nucleotide binding]; DNA binding site 266779006938 RNA-binding motif; other site 266779006939 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266779006940 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266779006941 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266779006942 Walker A/P-loop; other site 266779006943 ATP binding site [chemical binding]; other site 266779006944 Q-loop/lid; other site 266779006945 ABC transporter signature motif; other site 266779006946 Walker B; other site 266779006947 D-loop; other site 266779006948 H-loop/switch region; other site 266779006949 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266779006950 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266779006951 SnoaL-like domain; Region: SnoaL_2; pfam12680 266779006952 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266779006953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779006954 S-adenosylmethionine binding site [chemical binding]; other site 266779006955 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 266779006956 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 266779006957 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 266779006958 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 266779006959 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 266779006960 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266779006961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779006962 putative substrate translocation pore; other site 266779006963 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 266779006964 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266779006965 HlyD family secretion protein; Region: HlyD_3; pfam13437 266779006966 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266779006967 MarR family; Region: MarR_2; pfam12802 266779006968 homoserine dehydrogenase; Provisional; Region: PRK06349 266779006969 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 266779006970 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 266779006971 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 266779006972 aminotransferase; Validated; Region: PRK09148 266779006973 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266779006974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779006975 homodimer interface [polypeptide binding]; other site 266779006976 catalytic residue [active] 266779006977 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 266779006978 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 266779006979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 266779006980 Peptidase M15; Region: Peptidase_M15_3; cl01194 266779006981 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 266779006982 histidinol dehydrogenase; Region: hisD; TIGR00069 266779006983 NAD binding site [chemical binding]; other site 266779006984 dimerization interface [polypeptide binding]; other site 266779006985 product binding site; other site 266779006986 substrate binding site [chemical binding]; other site 266779006987 zinc binding site [ion binding]; other site 266779006988 catalytic residues [active] 266779006989 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266779006990 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266779006991 DNA binding site [nucleotide binding] 266779006992 domain linker motif; other site 266779006993 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 266779006994 putative dimerization interface [polypeptide binding]; other site 266779006995 putative ligand binding site [chemical binding]; other site 266779006996 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 266779006997 homotrimer interaction site [polypeptide binding]; other site 266779006998 putative active site [active] 266779006999 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 266779007000 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 266779007001 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266779007002 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266779007003 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266779007004 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266779007005 CoA binding domain; Region: CoA_binding_2; pfam13380 266779007006 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 266779007007 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 266779007008 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266779007009 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779007010 Walker A/P-loop; other site 266779007011 ATP binding site [chemical binding]; other site 266779007012 Q-loop/lid; other site 266779007013 ABC transporter signature motif; other site 266779007014 Walker B; other site 266779007015 D-loop; other site 266779007016 H-loop/switch region; other site 266779007017 TOBE domain; Region: TOBE_2; pfam08402 266779007018 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266779007019 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266779007020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779007021 dimer interface [polypeptide binding]; other site 266779007022 conserved gate region; other site 266779007023 putative PBP binding loops; other site 266779007024 ABC-ATPase subunit interface; other site 266779007025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266779007026 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266779007027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779007028 dimer interface [polypeptide binding]; other site 266779007029 conserved gate region; other site 266779007030 putative PBP binding loops; other site 266779007031 ABC-ATPase subunit interface; other site 266779007032 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266779007033 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266779007034 substrate binding site [chemical binding]; other site 266779007035 oxyanion hole (OAH) forming residues; other site 266779007036 trimer interface [polypeptide binding]; other site 266779007037 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266779007038 active site 266779007039 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 266779007040 dimer interaction site [polypeptide binding]; other site 266779007041 substrate-binding tunnel; other site 266779007042 active site 266779007043 catalytic site [active] 266779007044 substrate binding site [chemical binding]; other site 266779007045 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266779007046 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266779007047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779007048 dimer interface [polypeptide binding]; other site 266779007049 phosphorylation site [posttranslational modification] 266779007050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779007051 ATP binding site [chemical binding]; other site 266779007052 Mg2+ binding site [ion binding]; other site 266779007053 G-X-G motif; other site 266779007054 Response regulator receiver domain; Region: Response_reg; pfam00072 266779007055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779007056 active site 266779007057 phosphorylation site [posttranslational modification] 266779007058 intermolecular recognition site; other site 266779007059 dimerization interface [polypeptide binding]; other site 266779007060 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266779007061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779007062 active site 266779007063 phosphorylation site [posttranslational modification] 266779007064 intermolecular recognition site; other site 266779007065 Response regulator receiver domain; Region: Response_reg; pfam00072 266779007066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779007067 active site 266779007068 phosphorylation site [posttranslational modification] 266779007069 intermolecular recognition site; other site 266779007070 dimerization interface [polypeptide binding]; other site 266779007071 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 266779007072 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 266779007073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779007074 Response regulator receiver domain; Region: Response_reg; pfam00072 266779007075 active site 266779007076 phosphorylation site [posttranslational modification] 266779007077 intermolecular recognition site; other site 266779007078 dimerization interface [polypeptide binding]; other site 266779007079 PAS domain S-box; Region: sensory_box; TIGR00229 266779007080 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266779007081 putative active site [active] 266779007082 heme pocket [chemical binding]; other site 266779007083 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266779007084 HWE histidine kinase; Region: HWE_HK; smart00911 266779007085 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266779007086 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 266779007087 active site 266779007088 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266779007089 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266779007090 active site pocket [active] 266779007091 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 266779007092 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266779007093 putative active site [active] 266779007094 catalytic residue [active] 266779007095 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266779007096 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779007097 DNA-binding site [nucleotide binding]; DNA binding site 266779007098 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266779007099 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 266779007100 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266779007101 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 266779007102 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266779007103 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779007104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779007105 dimer interface [polypeptide binding]; other site 266779007106 conserved gate region; other site 266779007107 putative PBP binding loops; other site 266779007108 ABC-ATPase subunit interface; other site 266779007109 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266779007110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779007111 dimer interface [polypeptide binding]; other site 266779007112 conserved gate region; other site 266779007113 putative PBP binding loops; other site 266779007114 ABC-ATPase subunit interface; other site 266779007115 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266779007116 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779007117 Walker A/P-loop; other site 266779007118 ATP binding site [chemical binding]; other site 266779007119 Q-loop/lid; other site 266779007120 ABC transporter signature motif; other site 266779007121 Walker B; other site 266779007122 D-loop; other site 266779007123 H-loop/switch region; other site 266779007124 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779007125 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266779007126 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779007127 Walker A/P-loop; other site 266779007128 ATP binding site [chemical binding]; other site 266779007129 Q-loop/lid; other site 266779007130 ABC transporter signature motif; other site 266779007131 Walker B; other site 266779007132 D-loop; other site 266779007133 H-loop/switch region; other site 266779007134 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779007135 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165 266779007136 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266779007137 putative ligand binding site [chemical binding]; other site 266779007138 NAD binding site [chemical binding]; other site 266779007139 dimer interface [polypeptide binding]; other site 266779007140 putative catalytic site [active] 266779007141 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266779007142 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 266779007143 putative active site pocket [active] 266779007144 metal binding site [ion binding]; metal-binding site 266779007145 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266779007146 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266779007147 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266779007148 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 266779007149 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266779007150 NAD(P) binding site [chemical binding]; other site 266779007151 catalytic residues [active] 266779007152 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 266779007153 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 266779007154 classical (c) SDRs; Region: SDR_c; cd05233 266779007155 NAD(P) binding site [chemical binding]; other site 266779007156 active site 266779007157 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 266779007158 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 266779007159 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 266779007160 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 266779007161 hypothetical protein; Validated; Region: PRK09087 266779007162 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266779007163 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266779007164 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 266779007165 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 266779007166 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 266779007167 dimerization interface [polypeptide binding]; other site 266779007168 putative ATP binding site [chemical binding]; other site 266779007169 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 266779007170 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 266779007171 active site 266779007172 substrate binding site [chemical binding]; other site 266779007173 cosubstrate binding site; other site 266779007174 catalytic site [active] 266779007175 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 266779007176 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 266779007177 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 266779007178 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 266779007179 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 266779007180 putative [4Fe-4S] binding site [ion binding]; other site 266779007181 putative molybdopterin cofactor binding site [chemical binding]; other site 266779007182 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 266779007183 putative molybdopterin cofactor binding site; other site 266779007184 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 266779007185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266779007186 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 266779007187 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 266779007188 B1 nucleotide binding pocket [chemical binding]; other site 266779007189 B2 nucleotide binding pocket [chemical binding]; other site 266779007190 CAS motifs; other site 266779007191 active site 266779007192 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 266779007193 short chain dehydrogenase; Provisional; Region: PRK09134 266779007194 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 266779007195 NADP binding site [chemical binding]; other site 266779007196 substrate binding pocket [chemical binding]; other site 266779007197 active site 266779007198 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 266779007199 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 266779007200 GIY-YIG motif/motif A; other site 266779007201 active site 266779007202 catalytic site [active] 266779007203 putative DNA binding site [nucleotide binding]; other site 266779007204 metal binding site [ion binding]; metal-binding site 266779007205 UvrB/uvrC motif; Region: UVR; pfam02151 266779007206 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 266779007207 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 266779007208 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 266779007209 MoaE interaction surface [polypeptide binding]; other site 266779007210 MoeB interaction surface [polypeptide binding]; other site 266779007211 thiocarboxylated glycine; other site 266779007212 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 266779007213 MoaE homodimer interface [polypeptide binding]; other site 266779007214 MoaD interaction [polypeptide binding]; other site 266779007215 active site residues [active] 266779007216 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 266779007217 active site 266779007218 multimer interface [polypeptide binding]; other site 266779007219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 266779007220 DinB superfamily; Region: DinB_2; pfam12867 266779007221 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266779007222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266779007223 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 266779007224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 266779007225 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 266779007226 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 266779007227 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266779007228 FAD binding domain; Region: FAD_binding_4; pfam01565 266779007229 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266779007230 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 266779007231 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 266779007232 Part of AAA domain; Region: AAA_19; pfam13245 266779007233 Family description; Region: UvrD_C_2; pfam13538 266779007234 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 266779007235 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 266779007236 trimer interface [polypeptide binding]; other site 266779007237 active site 266779007238 substrate binding site [chemical binding]; other site 266779007239 CoA binding site [chemical binding]; other site 266779007240 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 266779007241 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 266779007242 Cu(I) binding site [ion binding]; other site 266779007243 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 266779007244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779007245 S-adenosylmethionine binding site [chemical binding]; other site 266779007246 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266779007247 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266779007248 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 266779007249 active site 266779007250 Predicted membrane protein [Function unknown]; Region: COG4541 266779007251 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 266779007252 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 266779007253 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 266779007254 nucleotide binding pocket [chemical binding]; other site 266779007255 K-X-D-G motif; other site 266779007256 catalytic site [active] 266779007257 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 266779007258 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 266779007259 Dimer interface [polypeptide binding]; other site 266779007260 BRCT sequence motif; other site 266779007261 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 266779007262 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 266779007263 Walker A/P-loop; other site 266779007264 ATP binding site [chemical binding]; other site 266779007265 Q-loop/lid; other site 266779007266 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 266779007267 ABC transporter signature motif; other site 266779007268 Walker B; other site 266779007269 D-loop; other site 266779007270 H-loop/switch region; other site 266779007271 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 266779007272 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 266779007273 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 266779007274 cell division protein FtsZ; Provisional; Region: PRK13018 266779007275 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 266779007276 nucleotide binding site [chemical binding]; other site 266779007277 SulA interaction site; other site 266779007278 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 266779007279 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 266779007280 Cell division protein FtsA; Region: FtsA; smart00842 266779007281 Cell division protein FtsA; Region: FtsA; pfam14450 266779007282 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 266779007283 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 266779007284 Cell division protein FtsQ; Region: FtsQ; pfam03799 266779007285 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 266779007286 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 266779007287 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266779007288 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 266779007289 FAD binding domain; Region: FAD_binding_4; pfam01565 266779007290 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 266779007291 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 266779007292 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266779007293 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266779007294 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266779007295 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 266779007296 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 266779007297 active site 266779007298 homodimer interface [polypeptide binding]; other site 266779007299 cell division protein FtsW; Region: ftsW; TIGR02614 266779007300 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 266779007301 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266779007302 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266779007303 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 266779007304 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 266779007305 Mg++ binding site [ion binding]; other site 266779007306 putative catalytic motif [active] 266779007307 putative substrate binding site [chemical binding]; other site 266779007308 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 266779007309 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266779007310 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266779007311 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266779007312 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 266779007313 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266779007314 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266779007315 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266779007316 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 266779007317 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 266779007318 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266779007319 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 266779007320 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 266779007321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779007322 S-adenosylmethionine binding site [chemical binding]; other site 266779007323 cell division protein MraZ; Reviewed; Region: PRK00326 266779007324 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266779007325 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266779007326 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266779007327 catalytic residue [active] 266779007328 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 266779007329 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 266779007330 amidase catalytic site [active] 266779007331 Zn binding residues [ion binding]; other site 266779007332 substrate binding site [chemical binding]; other site 266779007333 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266779007334 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 266779007335 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 266779007336 putative metal binding site [ion binding]; other site 266779007337 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266779007338 5-oxoprolinase; Region: PLN02666 266779007339 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266779007340 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266779007341 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266779007342 S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase [Lipid metabolism]; Region: BtaA; COG5379 266779007343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779007344 S-adenosylmethionine binding site [chemical binding]; other site 266779007345 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266779007346 Beta-lactamase; Region: Beta-lactamase; pfam00144 266779007347 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 266779007348 active site 266779007349 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 266779007350 lytic murein transglycosylase; Region: MltB_2; TIGR02283 266779007351 murein hydrolase B; Provisional; Region: PRK10760; cl17906 266779007352 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266779007353 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 266779007354 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 266779007355 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266779007356 catalytic residue [active] 266779007357 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 266779007358 FAD binding site [chemical binding]; other site 266779007359 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779007360 dimerization interface [polypeptide binding]; other site 266779007361 putative DNA binding site [nucleotide binding]; other site 266779007362 putative Zn2+ binding site [ion binding]; other site 266779007363 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266779007364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779007365 S-adenosylmethionine binding site [chemical binding]; other site 266779007366 Uncharacterized conserved protein [Function unknown]; Region: COG5586 266779007367 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 266779007368 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 266779007369 dimer interface [polypeptide binding]; other site 266779007370 active site 266779007371 CoA binding pocket [chemical binding]; other site 266779007372 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266779007373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 266779007374 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 266779007375 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266779007376 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266779007377 ABC transporter; Region: ABC_tran_2; pfam12848 266779007378 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266779007379 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 266779007380 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266779007381 FOG: CBS domain [General function prediction only]; Region: COG0517 266779007382 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 266779007383 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266779007384 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266779007385 thiamine pyrophosphate protein; Validated; Region: PRK08199 266779007386 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266779007387 PYR/PP interface [polypeptide binding]; other site 266779007388 dimer interface [polypeptide binding]; other site 266779007389 TPP binding site [chemical binding]; other site 266779007390 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266779007391 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266779007392 TPP-binding site [chemical binding]; other site 266779007393 Domain of unknown function (DUF2019); Region: DUF2019; pfam09450 266779007394 Domain of unknown function (DUF2019); Region: DUF2019; pfam09450 266779007395 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266779007396 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 266779007397 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 266779007398 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266779007399 inhibitor-cofactor binding pocket; inhibition site 266779007400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779007401 catalytic residue [active] 266779007402 allantoate amidohydrolase; Reviewed; Region: PRK12893 266779007403 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266779007404 active site 266779007405 metal binding site [ion binding]; metal-binding site 266779007406 dimer interface [polypeptide binding]; other site 266779007407 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266779007408 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266779007409 Walker A/P-loop; other site 266779007410 ATP binding site [chemical binding]; other site 266779007411 Q-loop/lid; other site 266779007412 ABC transporter signature motif; other site 266779007413 Walker B; other site 266779007414 D-loop; other site 266779007415 H-loop/switch region; other site 266779007416 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266779007417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779007418 dimer interface [polypeptide binding]; other site 266779007419 conserved gate region; other site 266779007420 putative PBP binding loops; other site 266779007421 ABC-ATPase subunit interface; other site 266779007422 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266779007423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779007424 dimer interface [polypeptide binding]; other site 266779007425 conserved gate region; other site 266779007426 putative PBP binding loops; other site 266779007427 ABC-ATPase subunit interface; other site 266779007428 NMT1/THI5 like; Region: NMT1; pfam09084 266779007429 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 266779007430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779007431 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 266779007432 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 266779007433 heterodimer interface [polypeptide binding]; other site 266779007434 multimer interface [polypeptide binding]; other site 266779007435 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 266779007436 active site 266779007437 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 266779007438 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 266779007439 heterodimer interface [polypeptide binding]; other site 266779007440 active site 266779007441 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975 266779007442 tetramer interface [polypeptide binding]; other site 266779007443 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266779007444 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266779007445 Predicted transcriptional regulator [Transcription]; Region: COG1959 266779007446 Transcriptional regulator; Region: Rrf2; pfam02082 266779007447 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 266779007448 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 266779007449 homodimer interface [polypeptide binding]; other site 266779007450 active site 266779007451 FMN binding site [chemical binding]; other site 266779007452 substrate binding site [chemical binding]; other site 266779007453 4Fe-4S binding domain; Region: Fer4_6; pfam12837 266779007454 4Fe-4S binding domain; Region: Fer4; pfam00037 266779007455 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266779007456 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 266779007457 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 266779007458 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266779007459 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 266779007460 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266779007461 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266779007462 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 266779007463 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 266779007464 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779007465 Walker A/P-loop; other site 266779007466 ATP binding site [chemical binding]; other site 266779007467 Q-loop/lid; other site 266779007468 ABC transporter signature motif; other site 266779007469 Walker B; other site 266779007470 D-loop; other site 266779007471 H-loop/switch region; other site 266779007472 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779007473 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779007474 Walker A/P-loop; other site 266779007475 ATP binding site [chemical binding]; other site 266779007476 Q-loop/lid; other site 266779007477 ABC transporter signature motif; other site 266779007478 Walker B; other site 266779007479 D-loop; other site 266779007480 H-loop/switch region; other site 266779007481 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779007482 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266779007483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779007484 dimer interface [polypeptide binding]; other site 266779007485 conserved gate region; other site 266779007486 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779007487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779007488 dimer interface [polypeptide binding]; other site 266779007489 conserved gate region; other site 266779007490 putative PBP binding loops; other site 266779007491 ABC-ATPase subunit interface; other site 266779007492 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266779007493 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266779007494 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 266779007495 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266779007496 N-terminal plug; other site 266779007497 ligand-binding site [chemical binding]; other site 266779007498 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 266779007499 intersubunit interface [polypeptide binding]; other site 266779007500 FecCD transport family; Region: FecCD; pfam01032 266779007501 ABC-ATPase subunit interface; other site 266779007502 dimer interface [polypeptide binding]; other site 266779007503 putative PBP binding regions; other site 266779007504 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 266779007505 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 266779007506 Walker A/P-loop; other site 266779007507 ATP binding site [chemical binding]; other site 266779007508 Q-loop/lid; other site 266779007509 ABC transporter signature motif; other site 266779007510 Walker B; other site 266779007511 D-loop; other site 266779007512 H-loop/switch region; other site 266779007513 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 266779007514 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 266779007515 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266779007516 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266779007517 ligand binding site [chemical binding]; other site 266779007518 hypothetical protein; Provisional; Region: PRK05170 266779007519 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266779007520 Uncharacterized conserved protein [Function unknown]; Region: COG2968 266779007521 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 266779007522 Protein of unknown function (DUF983); Region: DUF983; cl02211 266779007523 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266779007524 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266779007525 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 266779007526 active site 266779007527 catalytic residue [active] 266779007528 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 266779007529 pseudoazurin; Region: pseudoazurin; TIGR02375 266779007530 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266779007531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779007532 dimer interface [polypeptide binding]; other site 266779007533 conserved gate region; other site 266779007534 putative PBP binding loops; other site 266779007535 ABC-ATPase subunit interface; other site 266779007536 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266779007537 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266779007538 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266779007539 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266779007540 Walker A/P-loop; other site 266779007541 ATP binding site [chemical binding]; other site 266779007542 Q-loop/lid; other site 266779007543 ABC transporter signature motif; other site 266779007544 Walker B; other site 266779007545 D-loop; other site 266779007546 H-loop/switch region; other site 266779007547 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 266779007548 transmembrane helices; other site 266779007549 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 266779007550 TrkA-C domain; Region: TrkA_C; pfam02080 266779007551 TrkA-C domain; Region: TrkA_C; pfam02080 266779007552 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 266779007553 Uncharacterized conserved protein [Function unknown]; Region: COG1610 266779007554 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 266779007555 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 266779007556 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 266779007557 catalytic site [active] 266779007558 subunit interface [polypeptide binding]; other site 266779007559 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266779007560 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 266779007561 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 266779007562 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266779007563 SeqA protein; Region: SeqA; cl11470 266779007564 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266779007565 metal ion-dependent adhesion site (MIDAS); other site 266779007566 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 266779007567 Predicted metalloprotease [General function prediction only]; Region: COG2321 266779007568 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 266779007569 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266779007570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779007571 S-adenosylmethionine binding site [chemical binding]; other site 266779007572 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 266779007573 putative hydrophobic ligand binding site [chemical binding]; other site 266779007574 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779007575 dimerization interface [polypeptide binding]; other site 266779007576 putative DNA binding site [nucleotide binding]; other site 266779007577 putative Zn2+ binding site [ion binding]; other site 266779007578 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266779007579 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266779007580 active site 266779007581 Predicted transcriptional regulators [Transcription]; Region: COG1733 266779007582 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779007583 dimerization interface [polypeptide binding]; other site 266779007584 putative Zn2+ binding site [ion binding]; other site 266779007585 putative DNA binding site [nucleotide binding]; other site 266779007586 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779007587 dimerization interface [polypeptide binding]; other site 266779007588 putative DNA binding site [nucleotide binding]; other site 266779007589 putative Zn2+ binding site [ion binding]; other site 266779007590 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 266779007591 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 266779007592 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266779007593 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266779007594 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 266779007595 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266779007596 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266779007597 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 266779007598 IMP binding site; other site 266779007599 dimer interface [polypeptide binding]; other site 266779007600 partial ornithine binding site; other site 266779007601 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 266779007602 putative active site [active] 266779007603 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 266779007604 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266779007605 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266779007606 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779007607 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 266779007608 Walker A/P-loop; other site 266779007609 ATP binding site [chemical binding]; other site 266779007610 Q-loop/lid; other site 266779007611 ABC transporter signature motif; other site 266779007612 Walker B; other site 266779007613 D-loop; other site 266779007614 H-loop/switch region; other site 266779007615 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 266779007616 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 266779007617 catalytic triad [active] 266779007618 putative active site [active] 266779007619 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 266779007620 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 266779007621 Autotransporter beta-domain; Region: Autotransporter; smart00869 266779007622 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266779007623 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266779007624 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266779007625 catalytic residue [active] 266779007626 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 266779007627 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266779007628 DNA binding site [nucleotide binding] 266779007629 active site 266779007630 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266779007631 aspartate aminotransferase; Provisional; Region: PRK05764 266779007632 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266779007633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779007634 homodimer interface [polypeptide binding]; other site 266779007635 catalytic residue [active] 266779007636 Amidinotransferase; Region: Amidinotransf; cl12043 266779007637 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 266779007638 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266779007639 MarR family; Region: MarR_2; pfam12802 266779007640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266779007641 Coenzyme A binding pocket [chemical binding]; other site 266779007642 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 266779007643 elongation factor G; Reviewed; Region: PRK12740 266779007644 G1 box; other site 266779007645 putative GEF interaction site [polypeptide binding]; other site 266779007646 GTP/Mg2+ binding site [chemical binding]; other site 266779007647 Switch I region; other site 266779007648 G2 box; other site 266779007649 G3 box; other site 266779007650 Switch II region; other site 266779007651 G4 box; other site 266779007652 G5 box; other site 266779007653 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 266779007654 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 266779007655 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 266779007656 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779007657 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779007658 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266779007659 putative effector binding pocket; other site 266779007660 dimerization interface [polypeptide binding]; other site 266779007661 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 266779007662 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266779007663 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266779007664 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266779007665 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779007666 putative DNA binding site [nucleotide binding]; other site 266779007667 putative Zn2+ binding site [ion binding]; other site 266779007668 AsnC family; Region: AsnC_trans_reg; pfam01037 266779007669 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 266779007670 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 266779007671 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266779007672 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266779007673 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 266779007674 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 266779007675 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266779007676 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 266779007677 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 266779007678 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 266779007679 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 266779007680 Domain of unknown function DUF21; Region: DUF21; pfam01595 266779007681 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266779007682 Transporter associated domain; Region: CorC_HlyC; smart01091 266779007683 Predicted flavoprotein [General function prediction only]; Region: COG0431 266779007684 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266779007685 Predicted transcriptional regulators [Transcription]; Region: COG1733 266779007686 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779007687 dimerization interface [polypeptide binding]; other site 266779007688 putative DNA binding site [nucleotide binding]; other site 266779007689 putative Zn2+ binding site [ion binding]; other site 266779007690 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 266779007691 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266779007692 extended (e) SDRs; Region: SDR_e; cd08946 266779007693 NAD(P) binding site [chemical binding]; other site 266779007694 active site 266779007695 substrate binding site [chemical binding]; other site 266779007696 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 266779007697 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 266779007698 substrate binding site; other site 266779007699 Manganese binding site; other site 266779007700 dimer interface; other site 266779007701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266779007702 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266779007703 NAD(P) binding site [chemical binding]; other site 266779007704 active site 266779007705 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 266779007706 excinuclease ABC subunit B; Provisional; Region: PRK05298 266779007707 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266779007708 ATP binding site [chemical binding]; other site 266779007709 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266779007710 nucleotide binding region [chemical binding]; other site 266779007711 ATP-binding site [chemical binding]; other site 266779007712 Ultra-violet resistance protein B; Region: UvrB; pfam12344 266779007713 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266779007714 DNA-binding site [nucleotide binding]; DNA binding site 266779007715 RNA-binding motif; other site 266779007716 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266779007717 DNA-binding site [nucleotide binding]; DNA binding site 266779007718 RNA-binding motif; other site 266779007719 BA14K-like protein; Region: BA14K; pfam07886 266779007720 BA14K-like protein; Region: BA14K; pfam07886 266779007721 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266779007722 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266779007723 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 266779007724 homodimer interface [polypeptide binding]; other site 266779007725 substrate-cofactor binding pocket; other site 266779007726 catalytic residue [active] 266779007727 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266779007728 MarR family; Region: MarR_2; pfam12802 266779007729 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266779007730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779007731 active site 266779007732 phosphorylation site [posttranslational modification] 266779007733 intermolecular recognition site; other site 266779007734 dimerization interface [polypeptide binding]; other site 266779007735 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266779007736 DNA binding site [nucleotide binding] 266779007737 SPW repeat; Region: SPW; pfam03779 266779007738 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266779007739 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266779007740 HAMP domain; Region: HAMP; pfam00672 266779007741 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266779007742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779007743 ATP binding site [chemical binding]; other site 266779007744 Mg2+ binding site [ion binding]; other site 266779007745 G-X-G motif; other site 266779007746 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK14607 266779007747 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 266779007748 dimer interface [polypeptide binding]; other site 266779007749 putative tRNA-binding site [nucleotide binding]; other site 266779007750 Uncharacterized conserved protein [Function unknown]; Region: COG5465 266779007751 Membrane fusogenic activity; Region: BMFP; pfam04380 266779007752 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 266779007753 Uncharacterized conserved protein [Function unknown]; Region: COG1565 266779007754 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 266779007755 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 266779007756 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266779007757 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266779007758 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266779007759 active site 266779007760 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 266779007761 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 266779007762 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266779007763 active site 266779007764 Protein of unknown function, DUF488; Region: DUF488; cl01246 266779007765 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 266779007766 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 266779007767 5S rRNA interface [nucleotide binding]; other site 266779007768 CTC domain interface [polypeptide binding]; other site 266779007769 L16 interface [polypeptide binding]; other site 266779007770 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 266779007771 putative active site [active] 266779007772 catalytic residue [active] 266779007773 GTP-binding protein YchF; Reviewed; Region: PRK09601 266779007774 YchF GTPase; Region: YchF; cd01900 266779007775 G1 box; other site 266779007776 GTP/Mg2+ binding site [chemical binding]; other site 266779007777 Switch I region; other site 266779007778 G2 box; other site 266779007779 Switch II region; other site 266779007780 G3 box; other site 266779007781 G4 box; other site 266779007782 G5 box; other site 266779007783 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 266779007784 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 266779007785 putative active site [active] 266779007786 putative catalytic site [active] 266779007787 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 266779007788 putative active site [active] 266779007789 putative catalytic site [active] 266779007790 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 266779007791 transmembrane helices; other site 266779007792 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 266779007793 TrkA-C domain; Region: TrkA_C; pfam02080 266779007794 TrkA-C domain; Region: TrkA_C; pfam02080 266779007795 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 266779007796 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 266779007797 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266779007798 active site 266779007799 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 266779007800 cytochrome b; Provisional; Region: CYTB; MTH00191 266779007801 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 266779007802 Qi binding site; other site 266779007803 intrachain domain interface; other site 266779007804 interchain domain interface [polypeptide binding]; other site 266779007805 heme bH binding site [chemical binding]; other site 266779007806 heme bL binding site [chemical binding]; other site 266779007807 Qo binding site; other site 266779007808 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 266779007809 interchain domain interface [polypeptide binding]; other site 266779007810 intrachain domain interface; other site 266779007811 Qi binding site; other site 266779007812 Qo binding site; other site 266779007813 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 266779007814 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 266779007815 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 266779007816 [2Fe-2S] cluster binding site [ion binding]; other site 266779007817 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266779007818 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 266779007819 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 266779007820 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 266779007821 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266779007822 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266779007823 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 266779007824 Walker A/P-loop; other site 266779007825 ATP binding site [chemical binding]; other site 266779007826 Q-loop/lid; other site 266779007827 ABC transporter signature motif; other site 266779007828 Walker B; other site 266779007829 D-loop; other site 266779007830 H-loop/switch region; other site 266779007831 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266779007832 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266779007833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779007834 Walker A/P-loop; other site 266779007835 ATP binding site [chemical binding]; other site 266779007836 Q-loop/lid; other site 266779007837 ABC transporter signature motif; other site 266779007838 Walker B; other site 266779007839 D-loop; other site 266779007840 H-loop/switch region; other site 266779007841 Protein of unknown function (DUF1059); Region: DUF1059; cl02284 266779007842 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 266779007843 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 266779007844 active site 266779007845 NTP binding site [chemical binding]; other site 266779007846 metal binding triad [ion binding]; metal-binding site 266779007847 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 266779007848 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 266779007849 putative active site [active] 266779007850 putative CoA binding site [chemical binding]; other site 266779007851 nudix motif; other site 266779007852 metal binding site [ion binding]; metal-binding site 266779007853 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 266779007854 MoxR-like ATPases [General function prediction only]; Region: COG0714 266779007855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 266779007856 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 266779007857 Protein of unknown function DUF58; Region: DUF58; pfam01882 266779007858 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 266779007859 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 266779007860 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 266779007861 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 266779007862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266779007863 Coenzyme A binding pocket [chemical binding]; other site 266779007864 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 266779007865 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 266779007866 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 266779007867 putative dimer interface [polypeptide binding]; other site 266779007868 N-terminal domain interface [polypeptide binding]; other site 266779007869 putative substrate binding pocket (H-site) [chemical binding]; other site 266779007870 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 266779007871 nudix motif; other site 266779007872 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266779007873 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 266779007874 putative active site [active] 266779007875 putative metal binding site [ion binding]; other site 266779007876 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266779007877 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 266779007878 2-isopropylmalate synthase; Validated; Region: PRK03739 266779007879 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 266779007880 active site 266779007881 catalytic residues [active] 266779007882 metal binding site [ion binding]; metal-binding site 266779007883 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 266779007884 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779007885 dimerization interface [polypeptide binding]; other site 266779007886 putative DNA binding site [nucleotide binding]; other site 266779007887 putative Zn2+ binding site [ion binding]; other site 266779007888 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266779007889 putative hydrophobic ligand binding site [chemical binding]; other site 266779007890 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266779007891 Predicted transcriptional regulators [Transcription]; Region: COG1733 266779007892 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266779007893 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266779007894 TAP-like protein; Region: Abhydrolase_4; pfam08386 266779007895 RibD C-terminal domain; Region: RibD_C; cl17279 266779007896 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 266779007897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 266779007898 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 266779007899 Cation efflux family; Region: Cation_efflux; pfam01545 266779007900 anthranilate synthase; Provisional; Region: PRK13566 266779007901 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 266779007902 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 266779007903 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 266779007904 glutamine binding [chemical binding]; other site 266779007905 catalytic triad [active] 266779007906 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 266779007907 active site 266779007908 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 266779007909 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 266779007910 Peptidase family M50; Region: Peptidase_M50; pfam02163 266779007911 active site 266779007912 putative substrate binding region [chemical binding]; other site 266779007913 FOG: CBS domain [General function prediction only]; Region: COG0517 266779007914 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 266779007915 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 266779007916 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266779007917 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 266779007918 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 266779007919 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 266779007920 Potassium binding sites [ion binding]; other site 266779007921 Cesium cation binding sites [ion binding]; other site 266779007922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345 266779007923 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 266779007924 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 266779007925 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 266779007926 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 266779007927 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 266779007928 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 266779007929 AAA domain; Region: AAA_13; pfam13166 266779007930 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 266779007931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 266779007932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779007933 Response regulator receiver domain; Region: Response_reg; pfam00072 266779007934 active site 266779007935 phosphorylation site [posttranslational modification] 266779007936 intermolecular recognition site; other site 266779007937 dimerization interface [polypeptide binding]; other site 266779007938 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266779007939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779007940 active site 266779007941 phosphorylation site [posttranslational modification] 266779007942 intermolecular recognition site; other site 266779007943 dimerization interface [polypeptide binding]; other site 266779007944 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266779007945 DNA binding site [nucleotide binding] 266779007946 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 266779007947 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 266779007948 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 266779007949 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 266779007950 Ligand Binding Site [chemical binding]; other site 266779007951 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266779007952 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266779007953 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266779007954 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266779007955 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 266779007956 catalytic residues [active] 266779007957 catalytic nucleophile [active] 266779007958 Recombinase; Region: Recombinase; pfam07508 266779007959 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 266779007960 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 266779007961 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266779007962 ligand binding site [chemical binding]; other site 266779007963 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266779007964 putative switch regulator; other site 266779007965 non-specific DNA interactions [nucleotide binding]; other site 266779007966 DNA binding site [nucleotide binding] 266779007967 sequence specific DNA binding site [nucleotide binding]; other site 266779007968 putative cAMP binding site [chemical binding]; other site 266779007969 Response regulator receiver domain; Region: Response_reg; pfam00072 266779007970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779007971 active site 266779007972 phosphorylation site [posttranslational modification] 266779007973 intermolecular recognition site; other site 266779007974 dimerization interface [polypeptide binding]; other site 266779007975 response regulator FixJ; Provisional; Region: fixJ; PRK09390 266779007976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779007977 active site 266779007978 phosphorylation site [posttranslational modification] 266779007979 intermolecular recognition site; other site 266779007980 dimerization interface [polypeptide binding]; other site 266779007981 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266779007982 DNA binding residues [nucleotide binding] 266779007983 dimerization interface [polypeptide binding]; other site 266779007984 PAS domain S-box; Region: sensory_box; TIGR00229 266779007985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266779007986 putative active site [active] 266779007987 heme pocket [chemical binding]; other site 266779007988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779007989 dimer interface [polypeptide binding]; other site 266779007990 phosphorylation site [posttranslational modification] 266779007991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779007992 ATP binding site [chemical binding]; other site 266779007993 Mg2+ binding site [ion binding]; other site 266779007994 G-X-G motif; other site 266779007995 short chain dehydrogenase; Provisional; Region: PRK06172 266779007996 classical (c) SDRs; Region: SDR_c; cd05233 266779007997 NAD(P) binding site [chemical binding]; other site 266779007998 active site 266779007999 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 266779008000 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 266779008001 active site 266779008002 catalytic site [active] 266779008003 substrate binding site [chemical binding]; other site 266779008004 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 266779008005 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 266779008006 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 266779008007 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266779008008 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266779008009 CoA binding domain; Region: CoA_binding_2; pfam13380 266779008010 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 266779008011 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 266779008012 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266779008013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266779008014 Coenzyme A binding pocket [chemical binding]; other site 266779008015 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266779008016 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266779008017 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266779008018 Ligand Binding Site [chemical binding]; other site 266779008019 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 266779008020 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 266779008021 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266779008022 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 266779008023 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266779008024 motif II; other site 266779008025 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 266779008026 FOG: CBS domain [General function prediction only]; Region: COG0517 266779008027 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 266779008028 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266779008029 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 266779008030 Acetokinase family; Region: Acetate_kinase; cl17229 266779008031 propionate/acetate kinase; Provisional; Region: PRK12379 266779008032 putative phosphoketolase; Provisional; Region: PRK05261 266779008033 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 266779008034 TPP-binding site; other site 266779008035 XFP C-terminal domain; Region: XFP_C; pfam09363 266779008036 Cytochrome c; Region: Cytochrom_C; cl11414 266779008037 Cytochrome c; Region: Cytochrom_C; pfam00034 266779008038 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266779008039 Ligand Binding Site [chemical binding]; other site 266779008040 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 266779008041 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 266779008042 putative substrate binding site [chemical binding]; other site 266779008043 nucleotide binding site [chemical binding]; other site 266779008044 nucleotide binding site [chemical binding]; other site 266779008045 homodimer interface [polypeptide binding]; other site 266779008046 ornithine carbamoyltransferase; Validated; Region: PRK02102 266779008047 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266779008048 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 266779008049 arginine deiminase; Provisional; Region: PRK01388 266779008050 Predicted membrane protein [Function unknown]; Region: COG1288 266779008051 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 266779008052 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 266779008053 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 266779008054 Multicopper oxidase; Region: Cu-oxidase; pfam00394 266779008055 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 266779008056 pseudoazurin; Region: pseudoazurin; TIGR02375 266779008057 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266779008058 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266779008059 ligand binding site [chemical binding]; other site 266779008060 flexible hinge region; other site 266779008061 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266779008062 putative switch regulator; other site 266779008063 non-specific DNA interactions [nucleotide binding]; other site 266779008064 DNA binding site [nucleotide binding] 266779008065 sequence specific DNA binding site [nucleotide binding]; other site 266779008066 putative cAMP binding site [chemical binding]; other site 266779008067 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 266779008068 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266779008069 Ligand Binding Site [chemical binding]; other site 266779008070 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 266779008071 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266779008072 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 266779008073 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 266779008074 Low-spin heme binding site [chemical binding]; other site 266779008075 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 266779008076 Putative water exit pathway; other site 266779008077 Binuclear center (active site) [active] 266779008078 Putative proton exit pathway; other site 266779008079 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 266779008080 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 266779008081 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 266779008082 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 266779008083 Cytochrome c; Region: Cytochrom_C; pfam00034 266779008084 Cytochrome c; Region: Cytochrom_C; pfam00034 266779008085 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 266779008086 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266779008087 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266779008088 metal-binding site [ion binding] 266779008089 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266779008090 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266779008091 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 266779008092 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266779008093 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 266779008094 Sulfate transporter family; Region: Sulfate_transp; pfam00916 266779008095 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266779008096 Helix-turn-helix; Region: HTH_3; pfam01381 266779008097 sequence-specific DNA binding site [nucleotide binding]; other site 266779008098 salt bridge; other site 266779008099 thioredoxin 2; Provisional; Region: PRK10996 266779008100 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266779008101 catalytic residues [active] 266779008102 Predicted membrane protein [Function unknown]; Region: COG3174 266779008103 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 266779008104 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266779008105 nudix motif; other site 266779008106 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266779008107 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 266779008108 putative NAD(P) binding site [chemical binding]; other site 266779008109 putative substrate binding site [chemical binding]; other site 266779008110 catalytic Zn binding site [ion binding]; other site 266779008111 structural Zn binding site [ion binding]; other site 266779008112 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 266779008113 BON domain; Region: BON; pfam04972 266779008114 BON domain; Region: BON; pfam04972 266779008115 BON domain; Region: BON; pfam04972 266779008116 Protein required for attachment to host cells; Region: Host_attach; pfam10116 266779008117 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 266779008118 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 266779008119 tetramer interface [polypeptide binding]; other site 266779008120 TPP-binding site [chemical binding]; other site 266779008121 heterodimer interface [polypeptide binding]; other site 266779008122 phosphorylation loop region [posttranslational modification] 266779008123 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 266779008124 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 266779008125 PYR/PP interface [polypeptide binding]; other site 266779008126 dimer interface [polypeptide binding]; other site 266779008127 TPP binding site [chemical binding]; other site 266779008128 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266779008129 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 266779008130 Zn binding site [ion binding]; other site 266779008131 toxin interface [polypeptide binding]; other site 266779008132 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 266779008133 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 266779008134 catalytic triad [active] 266779008135 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 266779008136 putative FMN binding site [chemical binding]; other site 266779008137 NADPH bind site [chemical binding]; other site 266779008138 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 266779008139 30S subunit binding site; other site 266779008140 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266779008141 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266779008142 putative dimer interface [polypeptide binding]; other site 266779008143 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 266779008144 Ca2+ binding site [ion binding]; other site 266779008145 Short C-terminal domain; Region: SHOCT; pfam09851 266779008146 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266779008147 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266779008148 ligand binding site [chemical binding]; other site 266779008149 flexible hinge region; other site 266779008150 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266779008151 putative switch regulator; other site 266779008152 non-specific DNA interactions [nucleotide binding]; other site 266779008153 DNA binding site [nucleotide binding] 266779008154 sequence specific DNA binding site [nucleotide binding]; other site 266779008155 putative cAMP binding site [chemical binding]; other site 266779008156 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 266779008157 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266779008158 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266779008159 Walker A/P-loop; other site 266779008160 ATP binding site [chemical binding]; other site 266779008161 Q-loop/lid; other site 266779008162 ABC transporter signature motif; other site 266779008163 Walker B; other site 266779008164 D-loop; other site 266779008165 H-loop/switch region; other site 266779008166 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266779008167 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 266779008168 FtsX-like permease family; Region: FtsX; pfam02687 266779008169 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266779008170 FtsX-like permease family; Region: FtsX; pfam02687 266779008171 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266779008172 HlyD family secretion protein; Region: HlyD_3; pfam13437 266779008173 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 266779008174 Domain of unknown function DUF302; Region: DUF302; pfam03625 266779008175 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266779008176 Protein export membrane protein; Region: SecD_SecF; cl14618 266779008177 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 266779008178 HlyD family secretion protein; Region: HlyD_3; pfam13437 266779008179 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 266779008180 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 266779008181 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779008182 dimerization interface [polypeptide binding]; other site 266779008183 putative DNA binding site [nucleotide binding]; other site 266779008184 putative Zn2+ binding site [ion binding]; other site 266779008185 putative succinate dehydrogenase; Reviewed; Region: PRK12842 266779008186 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 266779008187 NIPSNAP; Region: NIPSNAP; pfam07978 266779008188 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 266779008189 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 266779008190 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 266779008191 shikimate binding site; other site 266779008192 NAD(P) binding site [chemical binding]; other site 266779008193 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 266779008194 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266779008195 Amidase; Region: Amidase; cl11426 266779008196 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266779008197 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266779008198 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266779008199 Beta-lactamase; Region: Beta-lactamase; pfam00144 266779008200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779008201 putative DNA binding site [nucleotide binding]; other site 266779008202 Predicted transcriptional regulators [Transcription]; Region: COG1777 266779008203 putative Zn2+ binding site [ion binding]; other site 266779008204 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266779008205 putative hydrophobic ligand binding site [chemical binding]; other site 266779008206 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 266779008207 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266779008208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779008209 Walker A/P-loop; other site 266779008210 ATP binding site [chemical binding]; other site 266779008211 Q-loop/lid; other site 266779008212 ABC transporter signature motif; other site 266779008213 Walker B; other site 266779008214 D-loop; other site 266779008215 H-loop/switch region; other site 266779008216 TOBE domain; Region: TOBE_2; pfam08402 266779008217 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266779008218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779008219 dimer interface [polypeptide binding]; other site 266779008220 conserved gate region; other site 266779008221 putative PBP binding loops; other site 266779008222 ABC-ATPase subunit interface; other site 266779008223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779008224 dimer interface [polypeptide binding]; other site 266779008225 conserved gate region; other site 266779008226 putative PBP binding loops; other site 266779008227 ABC-ATPase subunit interface; other site 266779008228 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266779008229 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266779008230 Isochorismatase family; Region: Isochorismatase; pfam00857 266779008231 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266779008232 catalytic triad [active] 266779008233 conserved cis-peptide bond; other site 266779008234 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266779008235 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266779008236 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 266779008237 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266779008238 Bacterial transcriptional regulator; Region: IclR; pfam01614 266779008239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266779008240 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266779008241 NAD(P) binding site [chemical binding]; other site 266779008242 active site 266779008243 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 266779008244 active site 266779008245 catalytic residue [active] 266779008246 Autoinducer binding domain; Region: Autoind_bind; pfam03472 266779008247 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266779008248 DNA binding residues [nucleotide binding] 266779008249 dimerization interface [polypeptide binding]; other site 266779008250 Autoinducer synthetase; Region: Autoind_synth; cl17404 266779008251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779008252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779008253 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266779008254 dimerization interface [polypeptide binding]; other site 266779008255 substrate binding pocket [chemical binding]; other site 266779008256 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 266779008257 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 266779008258 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266779008259 VirB7 interaction site; other site 266779008260 conjugal transfer protein TrbF; Provisional; Region: PRK13872 266779008261 conjugal transfer protein TrbL; Provisional; Region: PRK13875 266779008262 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 266779008263 conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360 266779008264 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 266779008265 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 266779008266 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 266779008267 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266779008268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779008269 Walker A/P-loop; other site 266779008270 ATP binding site [chemical binding]; other site 266779008271 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 266779008272 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 266779008273 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 266779008274 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266779008275 Walker A motif; other site 266779008276 ATP binding site [chemical binding]; other site 266779008277 Walker B motif; other site 266779008278 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 266779008279 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266779008280 motif II; other site 266779008281 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 266779008282 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 266779008283 Walker A motif; other site 266779008284 ATP binding site [chemical binding]; other site 266779008285 Walker B motif; other site 266779008286 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266779008287 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266779008288 non-specific DNA binding site [nucleotide binding]; other site 266779008289 salt bridge; other site 266779008290 sequence-specific DNA binding site [nucleotide binding]; other site 266779008291 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 266779008292 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 266779008293 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266779008294 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266779008295 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266779008296 catalytic residue [active] 266779008297 Protein of unknown function (DUF736); Region: DUF736; pfam05284 266779008298 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 266779008299 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 266779008300 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 266779008301 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 266779008302 ParA-like protein; Provisional; Region: PHA02518 266779008303 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266779008304 P-loop; other site 266779008305 Magnesium ion binding site [ion binding]; other site 266779008306 Helix-turn-helix domain; Region: HTH_17; pfam12728 266779008307 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 266779008308 Uncharacterized conserved protein [Function unknown]; Region: COG5489 266779008309 Protein of unknown function (DUF736); Region: DUF736; cl02303 266779008310 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 266779008311 Toprim domain; Region: Toprim_3; pfam13362 266779008312 ParB-like nuclease domain; Region: ParB; smart00470 266779008313 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 266779008314 putative active site [active] 266779008315 hypothetical protein; Provisional; Region: PRK01184 266779008316 hypothetical protein; Provisional; Region: PRK08356 266779008317 beta-RFAP synthase; Region: beta_RFAP_syn; TIGR00144 266779008318 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 266779008319 Active Sites [active] 266779008320 Methyltransferase domain; Region: Methyltransf_26; pfam13659 266779008321 HTH domain; Region: HTH_11; pfam08279 266779008322 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266779008323 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779008324 DNA-binding site [nucleotide binding]; DNA binding site 266779008325 FCD domain; Region: FCD; pfam07729 266779008326 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266779008327 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 266779008328 homodimer interface [polypeptide binding]; other site 266779008329 substrate-cofactor binding pocket; other site 266779008330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779008331 catalytic residue [active] 266779008332 Creatinine amidohydrolase; Region: Creatininase; pfam02633 266779008333 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266779008334 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266779008335 active site 266779008336 non-prolyl cis peptide bond; other site 266779008337 H+ Antiporter protein; Region: 2A0121; TIGR00900 266779008338 cystathionine beta-lyase; Provisional; Region: PRK07050 266779008339 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266779008340 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266779008341 catalytic residue [active] 266779008342 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266779008343 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266779008344 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266779008345 active site 266779008346 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266779008347 active sites [active] 266779008348 argininosuccinate lyase; Provisional; Region: PRK00855 266779008349 tetramer interface [polypeptide binding]; other site 266779008350 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266779008351 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266779008352 Bacterial transcriptional regulator; Region: IclR; pfam01614 266779008353 chaperonin GroEL; Reviewed; Region: groEL; PRK12851 266779008354 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 266779008355 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266779008356 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779008357 Walker A/P-loop; other site 266779008358 ATP binding site [chemical binding]; other site 266779008359 Q-loop/lid; other site 266779008360 ABC transporter signature motif; other site 266779008361 Walker B; other site 266779008362 D-loop; other site 266779008363 H-loop/switch region; other site 266779008364 TOBE domain; Region: TOBE_2; pfam08402 266779008365 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266779008366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779008367 dimer interface [polypeptide binding]; other site 266779008368 conserved gate region; other site 266779008369 putative PBP binding loops; other site 266779008370 ABC-ATPase subunit interface; other site 266779008371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779008372 dimer interface [polypeptide binding]; other site 266779008373 conserved gate region; other site 266779008374 putative PBP binding loops; other site 266779008375 ABC-ATPase subunit interface; other site 266779008376 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266779008377 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266779008378 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266779008379 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266779008380 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266779008381 catalytic residue [active] 266779008382 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266779008383 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266779008384 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266779008385 active site 266779008386 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 266779008387 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266779008388 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266779008389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779008390 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266779008391 dimerization interface [polypeptide binding]; other site 266779008392 substrate binding pocket [chemical binding]; other site 266779008393 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266779008394 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266779008395 active site 266779008396 non-prolyl cis peptide bond; other site 266779008397 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266779008398 Amidase; Region: Amidase; pfam01425 266779008399 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266779008400 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266779008401 Bacterial transcriptional regulator; Region: IclR; pfam01614 266779008402 cystathionine beta-lyase; Provisional; Region: PRK07050 266779008403 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266779008404 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266779008405 catalytic residue [active] 266779008406 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779008407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779008408 dimer interface [polypeptide binding]; other site 266779008409 conserved gate region; other site 266779008410 putative PBP binding loops; other site 266779008411 ABC-ATPase subunit interface; other site 266779008412 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266779008413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779008414 dimer interface [polypeptide binding]; other site 266779008415 conserved gate region; other site 266779008416 ABC-ATPase subunit interface; other site 266779008417 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266779008418 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779008419 Walker A/P-loop; other site 266779008420 ATP binding site [chemical binding]; other site 266779008421 Q-loop/lid; other site 266779008422 ABC transporter signature motif; other site 266779008423 Walker B; other site 266779008424 D-loop; other site 266779008425 H-loop/switch region; other site 266779008426 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779008427 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 266779008428 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266779008429 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779008430 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266779008431 dimerization interface [polypeptide binding]; other site 266779008432 substrate binding pocket [chemical binding]; other site 266779008433 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 266779008434 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266779008435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266779008436 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266779008437 active sites [active] 266779008438 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 266779008439 tetramer interface [polypeptide binding]; other site 266779008440 Helix-turn-helix domain; Region: HTH_17; pfam12728 266779008441 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 266779008442 dimer interface [polypeptide binding]; other site 266779008443 active site 266779008444 coenzyme A binding site [chemical binding]; other site 266779008445 citrylCoA binding site [chemical binding]; other site 266779008446 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 266779008447 oxalacetate/citrate binding site [chemical binding]; other site 266779008448 catalytic triad [active] 266779008449 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 266779008450 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266779008451 active sites [active] 266779008452 tetramer interface [polypeptide binding]; other site 266779008453 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 266779008454 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 266779008455 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266779008456 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266779008457 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266779008458 active site 266779008459 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 266779008460 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 266779008461 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 266779008462 active site 266779008463 Enolase C-terminal domain-like; Region: MR_MLE_C; pfam13378 266779008464 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 266779008465 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266779008466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266779008467 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 266779008468 homotrimer interaction site [polypeptide binding]; other site 266779008469 putative active site [active] 266779008470 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 266779008471 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 266779008472 phosphate binding site [ion binding]; other site 266779008473 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266779008474 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779008475 Walker A/P-loop; other site 266779008476 ATP binding site [chemical binding]; other site 266779008477 Q-loop/lid; other site 266779008478 ABC transporter signature motif; other site 266779008479 Walker B; other site 266779008480 D-loop; other site 266779008481 H-loop/switch region; other site 266779008482 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266779008483 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779008484 Walker A/P-loop; other site 266779008485 ATP binding site [chemical binding]; other site 266779008486 Q-loop/lid; other site 266779008487 ABC transporter signature motif; other site 266779008488 Walker B; other site 266779008489 D-loop; other site 266779008490 H-loop/switch region; other site 266779008491 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266779008492 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 266779008493 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 266779008494 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 266779008495 active site 266779008496 putative substrate binding pocket [chemical binding]; other site 266779008497 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266779008498 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 266779008499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779008500 dimer interface [polypeptide binding]; other site 266779008501 conserved gate region; other site 266779008502 putative PBP binding loops; other site 266779008503 ABC-ATPase subunit interface; other site 266779008504 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779008505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779008506 dimer interface [polypeptide binding]; other site 266779008507 conserved gate region; other site 266779008508 putative PBP binding loops; other site 266779008509 ABC-ATPase subunit interface; other site 266779008510 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266779008511 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 266779008512 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779008513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779008514 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266779008515 putative effector binding pocket; other site 266779008516 dimerization interface [polypeptide binding]; other site 266779008517 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266779008518 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 266779008519 putative binding site; other site 266779008520 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266779008521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779008522 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779008523 Domain of unknown function DUF11; Region: DUF11; cl17728 266779008524 conserved repeat domain; Region: B_ant_repeat; TIGR01451 266779008525 conserved repeat domain; Region: B_ant_repeat; TIGR01451 266779008526 Domain of unknown function DUF11; Region: DUF11; cl17728 266779008527 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 266779008528 hypothetical protein; Provisional; Region: PRK07482 266779008529 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266779008530 inhibitor-cofactor binding pocket; inhibition site 266779008531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779008532 catalytic residue [active] 266779008533 succinic semialdehyde dehydrogenase; Region: PLN02278 266779008534 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266779008535 tetramerization interface [polypeptide binding]; other site 266779008536 NAD(P) binding site [chemical binding]; other site 266779008537 catalytic residues [active] 266779008538 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266779008539 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779008540 putative DNA binding site [nucleotide binding]; other site 266779008541 putative Zn2+ binding site [ion binding]; other site 266779008542 AsnC family; Region: AsnC_trans_reg; pfam01037 266779008543 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 266779008544 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266779008545 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266779008546 active site 266779008547 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266779008548 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 266779008549 metal binding site [ion binding]; metal-binding site 266779008550 putative dimer interface [polypeptide binding]; other site 266779008551 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 266779008552 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 266779008553 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 266779008554 catalytic site [active] 266779008555 active site 266779008556 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 266779008557 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 266779008558 UV-endonuclease UvdE; Region: UvdE; cl10036 266779008559 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 266779008560 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 266779008561 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 266779008562 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 266779008563 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 266779008564 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266779008565 catalytic loop [active] 266779008566 iron binding site [ion binding]; other site 266779008567 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266779008568 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 266779008569 [4Fe-4S] binding site [ion binding]; other site 266779008570 molybdopterin cofactor binding site; other site 266779008571 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 266779008572 molybdopterin cofactor binding site; other site 266779008573 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 266779008574 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 266779008575 putative dimer interface [polypeptide binding]; other site 266779008576 [2Fe-2S] cluster binding site [ion binding]; other site 266779008577 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 266779008578 SLBB domain; Region: SLBB; pfam10531 266779008579 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 266779008580 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 266779008581 CPxP motif; other site 266779008582 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 266779008583 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 266779008584 dimer interface [polypeptide binding]; other site 266779008585 putative functional site; other site 266779008586 putative MPT binding site; other site 266779008587 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 266779008588 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 266779008589 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 266779008590 GTP binding site; other site 266779008591 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 266779008592 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 266779008593 dimer interface [polypeptide binding]; other site 266779008594 putative functional site; other site 266779008595 putative MPT binding site; other site 266779008596 PBP superfamily domain; Region: PBP_like; pfam12727 266779008597 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 266779008598 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 266779008599 MPT binding site; other site 266779008600 PBP superfamily domain; Region: PBP_like_2; pfam12849 266779008601 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266779008602 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266779008603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779008604 Walker A/P-loop; other site 266779008605 ATP binding site [chemical binding]; other site 266779008606 Q-loop/lid; other site 266779008607 ABC transporter signature motif; other site 266779008608 Walker B; other site 266779008609 D-loop; other site 266779008610 H-loop/switch region; other site 266779008611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779008612 dimer interface [polypeptide binding]; other site 266779008613 conserved gate region; other site 266779008614 putative PBP binding loops; other site 266779008615 ABC-ATPase subunit interface; other site 266779008616 Helix-turn-helix domain; Region: HTH_17; pfam12728 266779008617 PBP superfamily domain; Region: PBP_like; pfam12727 266779008618 FOG: WD40 repeat [General function prediction only]; Region: COG2319 266779008619 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 266779008620 structural tetrad; other site 266779008621 Cytochrome c; Region: Cytochrom_C; cl11414 266779008622 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 266779008623 4Fe-4S binding domain; Region: Fer4; pfam00037 266779008624 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 266779008625 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 266779008626 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 266779008627 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 266779008628 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 266779008629 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 266779008630 [4Fe-4S] binding site [ion binding]; other site 266779008631 molybdopterin cofactor binding site; other site 266779008632 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266779008633 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 266779008634 molybdopterin cofactor binding site; other site 266779008635 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 266779008636 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 266779008637 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 266779008638 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266779008639 active site 266779008640 metal binding site [ion binding]; metal-binding site 266779008641 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266779008642 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266779008643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266779008644 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 266779008645 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266779008646 MarR family; Region: MarR; pfam01047 266779008647 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 266779008648 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266779008649 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266779008650 dimerization interface [polypeptide binding]; other site 266779008651 DNA binding residues [nucleotide binding] 266779008652 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266779008653 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 266779008654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779008655 S-adenosylmethionine binding site [chemical binding]; other site 266779008656 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266779008657 FAD binding domain; Region: FAD_binding_4; pfam01565 266779008658 Berberine and berberine like; Region: BBE; pfam08031 266779008659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779008660 Domain of unknown function (DUF718); Region: DUF718; cl01281 266779008661 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779008662 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779008663 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266779008664 dimerization interface [polypeptide binding]; other site 266779008665 MarR family; Region: MarR_2; cl17246 266779008666 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266779008667 Flavin Reductases; Region: FlaRed; cl00801 266779008668 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 266779008669 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 266779008670 Cupin domain; Region: Cupin_2; cl17218 266779008671 Helix-turn-helix domain; Region: HTH_18; pfam12833 266779008672 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779008673 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266779008674 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266779008675 metal binding site [ion binding]; metal-binding site 266779008676 active site 266779008677 I-site; other site 266779008678 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 266779008679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266779008680 Coenzyme A binding pocket [chemical binding]; other site 266779008681 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266779008682 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 266779008683 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 266779008684 active site 266779008685 dimer interface [polypeptide binding]; other site 266779008686 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 266779008687 Ligand Binding Site [chemical binding]; other site 266779008688 Molecular Tunnel; other site 266779008689 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266779008690 MarR family; Region: MarR; pfam01047 266779008691 BCCT family transporter; Region: BCCT; pfam02028 266779008692 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 266779008693 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266779008694 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266779008695 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 266779008696 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 266779008697 Subunit I/III interface [polypeptide binding]; other site 266779008698 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 266779008699 Subunit I/III interface [polypeptide binding]; other site 266779008700 Predicted small integral membrane protein [Function unknown]; Region: COG5605 266779008701 Predicted integral membrane protein [Function unknown]; Region: COG5473 266779008702 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266779008703 homotrimer interaction site [polypeptide binding]; other site 266779008704 putative active site [active] 266779008705 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 266779008706 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266779008707 FAD binding site [chemical binding]; other site 266779008708 substrate binding pocket [chemical binding]; other site 266779008709 catalytic base [active] 266779008710 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266779008711 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779008712 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266779008713 dimerization interface [polypeptide binding]; other site 266779008714 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 266779008715 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 266779008716 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 266779008717 Predicted integral membrane protein [Function unknown]; Region: COG0392 266779008718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 266779008719 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266779008720 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 266779008721 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266779008722 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779008723 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 266779008724 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266779008725 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 266779008726 DctM-like transporters; Region: DctM; pfam06808 266779008727 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 266779008728 Cupin domain; Region: Cupin_2; cl17218 266779008729 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266779008730 classical (c) SDRs; Region: SDR_c; cd05233 266779008731 NAD(P) binding site [chemical binding]; other site 266779008732 active site 266779008733 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266779008734 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 266779008735 NAD(P) binding site [chemical binding]; other site 266779008736 catalytic residues [active] 266779008737 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266779008738 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266779008739 Walker A/P-loop; other site 266779008740 ATP binding site [chemical binding]; other site 266779008741 Q-loop/lid; other site 266779008742 ABC transporter signature motif; other site 266779008743 Walker B; other site 266779008744 D-loop; other site 266779008745 H-loop/switch region; other site 266779008746 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266779008747 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266779008748 Walker A/P-loop; other site 266779008749 ATP binding site [chemical binding]; other site 266779008750 Q-loop/lid; other site 266779008751 ABC transporter signature motif; other site 266779008752 Walker B; other site 266779008753 D-loop; other site 266779008754 H-loop/switch region; other site 266779008755 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266779008756 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266779008757 TM-ABC transporter signature motif; other site 266779008758 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266779008759 TM-ABC transporter signature motif; other site 266779008760 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266779008761 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 266779008762 putative ligand binding site [chemical binding]; other site 266779008763 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266779008764 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 266779008765 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 266779008766 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 266779008767 FeS/SAM binding site; other site 266779008768 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 266779008769 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 266779008770 Fe-S cluster binding site [ion binding]; other site 266779008771 active site 266779008772 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 266779008773 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266779008774 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266779008775 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266779008776 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 266779008777 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 266779008778 tetramer interface [polypeptide binding]; other site 266779008779 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 266779008780 tetramer interface [polypeptide binding]; other site 266779008781 active site 266779008782 metal binding site [ion binding]; metal-binding site 266779008783 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 266779008784 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 266779008785 NAD binding site [chemical binding]; other site 266779008786 catalytic residues [active] 266779008787 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 266779008788 putative substrate binding pocket [chemical binding]; other site 266779008789 trimer interface [polypeptide binding]; other site 266779008790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266779008791 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266779008792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 266779008793 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 266779008794 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266779008795 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266779008796 tetramer interface [polypeptide binding]; other site 266779008797 active site 266779008798 Mg2+/Mn2+ binding site [ion binding]; other site 266779008799 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266779008800 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779008801 DNA-binding site [nucleotide binding]; DNA binding site 266779008802 FCD domain; Region: FCD; pfam07729 266779008803 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 266779008804 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266779008805 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266779008806 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 266779008807 DctM-like transporters; Region: DctM; pfam06808 266779008808 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 266779008809 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 266779008810 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266779008811 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266779008812 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779008813 DNA-binding site [nucleotide binding]; DNA binding site 266779008814 FCD domain; Region: FCD; pfam07729 266779008815 Amino acid synthesis; Region: AA_synth; pfam06684 266779008816 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 266779008817 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 266779008818 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 266779008819 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266779008820 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 266779008821 NAD(P) binding site [chemical binding]; other site 266779008822 catalytic residues [active] 266779008823 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266779008824 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 266779008825 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266779008826 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266779008827 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 266779008828 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266779008829 NIPSNAP; Region: NIPSNAP; pfam07978 266779008830 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 266779008831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779008832 Walker A/P-loop; other site 266779008833 ATP binding site [chemical binding]; other site 266779008834 Q-loop/lid; other site 266779008835 ABC transporter signature motif; other site 266779008836 Walker B; other site 266779008837 D-loop; other site 266779008838 H-loop/switch region; other site 266779008839 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 266779008840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779008841 dimer interface [polypeptide binding]; other site 266779008842 conserved gate region; other site 266779008843 putative PBP binding loops; other site 266779008844 ABC-ATPase subunit interface; other site 266779008845 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 266779008846 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266779008847 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266779008848 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 266779008849 metal binding site [ion binding]; metal-binding site 266779008850 putative dimer interface [polypeptide binding]; other site 266779008851 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266779008852 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266779008853 acyl-CoA synthetase; Validated; Region: PRK08162 266779008854 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 266779008855 acyl-activating enzyme (AAE) consensus motif; other site 266779008856 putative active site [active] 266779008857 AMP binding site [chemical binding]; other site 266779008858 putative CoA binding site [chemical binding]; other site 266779008859 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 266779008860 active site 266779008861 catalytic residue [active] 266779008862 Cupin domain; Region: Cupin_2; pfam07883 266779008863 Helix-turn-helix domain; Region: HTH_18; pfam12833 266779008864 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779008865 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 266779008866 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 266779008867 molybdopterin cofactor binding site [chemical binding]; other site 266779008868 substrate binding site [chemical binding]; other site 266779008869 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 266779008870 molybdopterin cofactor binding site; other site 266779008871 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266779008872 active sites [active] 266779008873 tetramer interface [polypeptide binding]; other site 266779008874 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266779008875 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779008876 Walker A/P-loop; other site 266779008877 ATP binding site [chemical binding]; other site 266779008878 Q-loop/lid; other site 266779008879 ABC transporter signature motif; other site 266779008880 Walker B; other site 266779008881 D-loop; other site 266779008882 H-loop/switch region; other site 266779008883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779008884 dimer interface [polypeptide binding]; other site 266779008885 conserved gate region; other site 266779008886 putative PBP binding loops; other site 266779008887 ABC-ATPase subunit interface; other site 266779008888 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 266779008889 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266779008890 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 266779008891 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266779008892 active site 266779008893 urocanate hydratase; Provisional; Region: PRK05414 266779008894 allantoate amidohydrolase; Reviewed; Region: PRK09290 266779008895 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266779008896 active site 266779008897 metal binding site [ion binding]; metal-binding site 266779008898 dimer interface [polypeptide binding]; other site 266779008899 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 266779008900 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266779008901 putative C-terminal domain interface [polypeptide binding]; other site 266779008902 putative GSH binding site (G-site) [chemical binding]; other site 266779008903 putative dimer interface [polypeptide binding]; other site 266779008904 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 266779008905 N-terminal domain interface [polypeptide binding]; other site 266779008906 dimer interface [polypeptide binding]; other site 266779008907 substrate binding pocket (H-site) [chemical binding]; other site 266779008908 Protein of unknown function (DUF917); Region: DUF917; cl17829 266779008909 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779008910 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779008911 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779008912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779008913 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266779008914 dimerization interface [polypeptide binding]; other site 266779008915 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 266779008916 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 266779008917 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266779008918 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266779008919 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 266779008920 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 266779008921 dimerization interface [polypeptide binding]; other site 266779008922 active site 266779008923 L-aspartate oxidase; Provisional; Region: PRK07512 266779008924 L-aspartate oxidase; Provisional; Region: PRK06175 266779008925 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266779008926 quinolinate synthetase; Provisional; Region: PRK09375 266779008927 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 266779008928 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 266779008929 oligomerization interface [polypeptide binding]; other site 266779008930 active site 266779008931 metal binding site [ion binding]; metal-binding site 266779008932 pantoate--beta-alanine ligase; Region: panC; TIGR00018 266779008933 Pantoate-beta-alanine ligase; Region: PanC; cd00560 266779008934 active site 266779008935 ATP-binding site [chemical binding]; other site 266779008936 pantoate-binding site; other site 266779008937 HXXH motif; other site 266779008938 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 266779008939 ThiC-associated domain; Region: ThiC-associated; pfam13667 266779008940 ThiC family; Region: ThiC; pfam01964 266779008941 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266779008942 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 266779008943 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 266779008944 thiS-thiF/thiG interaction site; other site 266779008945 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 266779008946 ThiS interaction site; other site 266779008947 putative active site [active] 266779008948 tetramer interface [polypeptide binding]; other site 266779008949 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 266779008950 thiamine phosphate binding site [chemical binding]; other site 266779008951 active site 266779008952 pyrophosphate binding site [ion binding]; other site 266779008953 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 266779008954 dimer interface [polypeptide binding]; other site 266779008955 substrate binding site [chemical binding]; other site 266779008956 ATP binding site [chemical binding]; other site 266779008957 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 266779008958 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266779008959 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266779008960 inhibitor site; inhibition site 266779008961 active site 266779008962 dimer interface [polypeptide binding]; other site 266779008963 catalytic residue [active] 266779008964 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266779008965 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779008966 DNA-binding site [nucleotide binding]; DNA binding site 266779008967 FCD domain; Region: FCD; pfam07729 266779008968 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 266779008969 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 266779008970 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 266779008971 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 266779008972 Cupin; Region: Cupin_6; pfam12852 266779008973 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779008974 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 266779008975 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266779008976 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266779008977 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266779008978 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266779008979 dimerization interface [polypeptide binding]; other site 266779008980 DNA binding residues [nucleotide binding] 266779008981 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266779008982 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266779008983 ligand binding site [chemical binding]; other site 266779008984 flexible hinge region; other site 266779008985 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266779008986 putative switch regulator; other site 266779008987 non-specific DNA interactions [nucleotide binding]; other site 266779008988 DNA binding site [nucleotide binding] 266779008989 sequence specific DNA binding site [nucleotide binding]; other site 266779008990 putative cAMP binding site [chemical binding]; other site 266779008991 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 266779008992 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 266779008993 active site 266779008994 catalytic residues [active] 266779008995 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 266779008996 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 266779008997 acyl-activating enzyme (AAE) consensus motif; other site 266779008998 AMP binding site [chemical binding]; other site 266779008999 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 266779009000 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 266779009001 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 266779009002 active site 266779009003 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 266779009004 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 266779009005 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 266779009006 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 266779009007 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266779009008 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266779009009 catalytic residue [active] 266779009010 Condensation domain; Region: Condensation; pfam00668 266779009011 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 266779009012 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 266779009013 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 266779009014 acyl-activating enzyme (AAE) consensus motif; other site 266779009015 AMP binding site [chemical binding]; other site 266779009016 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 266779009017 Condensation domain; Region: Condensation; pfam00668 266779009018 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 266779009019 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 266779009020 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 266779009021 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 266779009022 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 266779009023 inhibitor-cofactor binding pocket; inhibition site 266779009024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779009025 catalytic residue [active] 266779009026 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266779009027 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266779009028 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266779009029 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266779009030 putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325 266779009031 colanic acid exporter; Provisional; Region: PRK10459 266779009032 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 266779009033 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266779009034 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266779009035 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266779009036 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 266779009037 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266779009038 active site 266779009039 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 266779009040 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 266779009041 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266779009042 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266779009043 SLBB domain; Region: SLBB; pfam10531 266779009044 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 266779009045 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266779009046 putative ADP-binding pocket [chemical binding]; other site 266779009047 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 266779009048 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 266779009049 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 266779009050 Walker A/P-loop; other site 266779009051 ATP binding site [chemical binding]; other site 266779009052 Q-loop/lid; other site 266779009053 ABC transporter signature motif; other site 266779009054 Walker B; other site 266779009055 D-loop; other site 266779009056 H-loop/switch region; other site 266779009057 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 266779009058 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266779009059 HlyD family secretion protein; Region: HlyD_3; pfam13437 266779009060 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266779009061 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 266779009062 iron-sulfur cluster [ion binding]; other site 266779009063 [2Fe-2S] cluster binding site [ion binding]; other site 266779009064 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 266779009065 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 266779009066 dimer interface [polypeptide binding]; other site 266779009067 Trp docking motif [polypeptide binding]; other site 266779009068 active site 266779009069 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 266779009070 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 266779009071 Trp docking motif [polypeptide binding]; other site 266779009072 active site 266779009073 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 266779009074 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 266779009075 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 266779009076 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 266779009077 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 266779009078 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 266779009079 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 266779009080 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266779009081 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266779009082 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266779009083 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 266779009084 ligand binding site [chemical binding]; other site 266779009085 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266779009086 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266779009087 multidrug efflux protein; Reviewed; Region: PRK09579 266779009088 Protein export membrane protein; Region: SecD_SecF; cl14618 266779009089 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266779009090 HlyD family secretion protein; Region: HlyD_3; pfam13437 266779009091 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266779009092 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266779009093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 266779009094 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266779009095 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_1; cd08508 266779009096 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779009097 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 266779009098 Walker A/P-loop; other site 266779009099 ATP binding site [chemical binding]; other site 266779009100 Q-loop/lid; other site 266779009101 ABC transporter signature motif; other site 266779009102 Walker B; other site 266779009103 D-loop; other site 266779009104 H-loop/switch region; other site 266779009105 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779009106 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266779009107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779009108 dimer interface [polypeptide binding]; other site 266779009109 conserved gate region; other site 266779009110 putative PBP binding loops; other site 266779009111 ABC-ATPase subunit interface; other site 266779009112 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779009113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779009114 dimer interface [polypeptide binding]; other site 266779009115 conserved gate region; other site 266779009116 putative PBP binding loops; other site 266779009117 ABC-ATPase subunit interface; other site 266779009118 H+ Antiporter protein; Region: 2A0121; TIGR00900 266779009119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779009120 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266779009121 active sites [active] 266779009122 tetramer interface [polypeptide binding]; other site 266779009123 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266779009124 argininosuccinate lyase; Region: argH; TIGR00838 266779009125 active sites [active] 266779009126 tetramer interface [polypeptide binding]; other site 266779009127 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779009128 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779009129 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779009130 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779009131 LysR substrate binding domain; Region: LysR_substrate; pfam03466 266779009132 dimerization interface [polypeptide binding]; other site 266779009133 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266779009134 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 266779009135 active site 266779009136 FMN binding site [chemical binding]; other site 266779009137 substrate binding site [chemical binding]; other site 266779009138 homotetramer interface [polypeptide binding]; other site 266779009139 catalytic residue [active] 266779009140 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266779009141 active sites [active] 266779009142 tetramer interface [polypeptide binding]; other site 266779009143 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_1; cd08508 266779009144 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266779009145 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779009146 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 266779009147 Walker A/P-loop; other site 266779009148 ATP binding site [chemical binding]; other site 266779009149 Q-loop/lid; other site 266779009150 ABC transporter signature motif; other site 266779009151 Walker B; other site 266779009152 D-loop; other site 266779009153 H-loop/switch region; other site 266779009154 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266779009155 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266779009156 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779009157 Walker A/P-loop; other site 266779009158 ATP binding site [chemical binding]; other site 266779009159 Q-loop/lid; other site 266779009160 ABC transporter signature motif; other site 266779009161 Walker B; other site 266779009162 D-loop; other site 266779009163 H-loop/switch region; other site 266779009164 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779009165 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266779009166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779009167 putative PBP binding loops; other site 266779009168 ABC-ATPase subunit interface; other site 266779009169 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779009170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779009171 dimer interface [polypeptide binding]; other site 266779009172 conserved gate region; other site 266779009173 putative PBP binding loops; other site 266779009174 ABC-ATPase subunit interface; other site 266779009175 urocanate hydratase; Provisional; Region: PRK05414 266779009176 Protein of unknown function (DUF917); Region: DUF917; pfam06032 266779009177 allantoate amidohydrolase; Reviewed; Region: PRK12890 266779009178 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266779009179 active site 266779009180 metal binding site [ion binding]; metal-binding site 266779009181 dimer interface [polypeptide binding]; other site 266779009182 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 266779009183 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266779009184 active site 266779009185 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 266779009186 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 266779009187 active site residue [active] 266779009188 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 266779009189 active site residue [active] 266779009190 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266779009191 catalytic residues [active] 266779009192 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 266779009193 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266779009194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779009195 homodimer interface [polypeptide binding]; other site 266779009196 catalytic residue [active] 266779009197 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266779009198 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266779009199 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 266779009200 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 266779009201 molybdopterin cofactor binding site [chemical binding]; other site 266779009202 substrate binding site [chemical binding]; other site 266779009203 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 266779009204 molybdopterin cofactor binding site; other site 266779009205 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266779009206 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 266779009207 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266779009208 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266779009209 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266779009210 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266779009211 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 266779009212 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779009213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779009214 dimer interface [polypeptide binding]; other site 266779009215 conserved gate region; other site 266779009216 putative PBP binding loops; other site 266779009217 ABC-ATPase subunit interface; other site 266779009218 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266779009219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779009220 dimer interface [polypeptide binding]; other site 266779009221 conserved gate region; other site 266779009222 putative PBP binding loops; other site 266779009223 ABC-ATPase subunit interface; other site 266779009224 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266779009225 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779009226 Walker A/P-loop; other site 266779009227 ATP binding site [chemical binding]; other site 266779009228 Q-loop/lid; other site 266779009229 ABC transporter signature motif; other site 266779009230 Walker B; other site 266779009231 D-loop; other site 266779009232 H-loop/switch region; other site 266779009233 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779009234 Walker A/P-loop; other site 266779009235 ATP binding site [chemical binding]; other site 266779009236 Q-loop/lid; other site 266779009237 ABC transporter signature motif; other site 266779009238 Walker B; other site 266779009239 D-loop; other site 266779009240 H-loop/switch region; other site 266779009241 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266779009242 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266779009243 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266779009244 tetramerization interface [polypeptide binding]; other site 266779009245 NAD(P) binding site [chemical binding]; other site 266779009246 catalytic residues [active] 266779009247 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 266779009248 6-hydroxyhexanoate dehydrogenase (HHD) catalyzes the oxidation of 6-hydroxyhexanoate to 6-oxohexanoate; Region: HHD; cd08191 266779009249 putative active site [active] 266779009250 metal binding site [ion binding]; metal-binding site 266779009251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266779009252 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 266779009253 NAD(P) binding site [chemical binding]; other site 266779009254 active site 266779009255 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 266779009256 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266779009257 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266779009258 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 266779009259 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 266779009260 putative active site [active] 266779009261 putative metal binding site [ion binding]; other site 266779009262 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 266779009263 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 266779009264 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266779009265 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266779009266 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266779009267 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 266779009268 Walker A/P-loop; other site 266779009269 ATP binding site [chemical binding]; other site 266779009270 Q-loop/lid; other site 266779009271 ABC transporter signature motif; other site 266779009272 Walker B; other site 266779009273 D-loop; other site 266779009274 H-loop/switch region; other site 266779009275 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 266779009276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779009277 dimer interface [polypeptide binding]; other site 266779009278 conserved gate region; other site 266779009279 putative PBP binding loops; other site 266779009280 ABC-ATPase subunit interface; other site 266779009281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779009282 dimer interface [polypeptide binding]; other site 266779009283 conserved gate region; other site 266779009284 putative PBP binding loops; other site 266779009285 ABC-ATPase subunit interface; other site 266779009286 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 266779009287 NMT1/THI5 like; Region: NMT1; pfam09084 266779009288 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779009289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779009290 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266779009291 putative effector binding pocket; other site 266779009292 dimerization interface [polypeptide binding]; other site 266779009293 phenylhydantoinase; Validated; Region: PRK08323 266779009294 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 266779009295 tetramer interface [polypeptide binding]; other site 266779009296 active site 266779009297 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 266779009298 YHS domain; Region: YHS; pfam04945 266779009299 YHS domain; Region: YHS; pfam04945 266779009300 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266779009301 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266779009302 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266779009303 Transmembrane secretion effector; Region: MFS_3; pfam05977 266779009304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779009305 putative substrate translocation pore; other site 266779009306 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266779009307 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266779009308 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 266779009309 Walker A/P-loop; other site 266779009310 ATP binding site [chemical binding]; other site 266779009311 Q-loop/lid; other site 266779009312 ABC transporter signature motif; other site 266779009313 Walker B; other site 266779009314 D-loop; other site 266779009315 H-loop/switch region; other site 266779009316 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266779009317 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266779009318 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779009319 Walker A/P-loop; other site 266779009320 ATP binding site [chemical binding]; other site 266779009321 Q-loop/lid; other site 266779009322 ABC transporter signature motif; other site 266779009323 Walker B; other site 266779009324 D-loop; other site 266779009325 H-loop/switch region; other site 266779009326 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 266779009327 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 266779009328 substrate binding site [chemical binding]; other site 266779009329 catalytic Zn binding site [ion binding]; other site 266779009330 NAD binding site [chemical binding]; other site 266779009331 structural Zn binding site [ion binding]; other site 266779009332 dimer interface [polypeptide binding]; other site 266779009333 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 266779009334 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 266779009335 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 266779009336 active site 266779009337 catalytic site [active] 266779009338 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 266779009339 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 266779009340 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 266779009341 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 266779009342 catalytic site [active] 266779009343 active site 266779009344 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 266779009345 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 266779009346 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 266779009347 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 266779009348 active site 266779009349 catalytic site [active] 266779009350 glycogen branching enzyme; Provisional; Region: PRK05402 266779009351 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 266779009352 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 266779009353 active site 266779009354 catalytic site [active] 266779009355 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 266779009356 trehalose synthase; Region: treS_nterm; TIGR02456 266779009357 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 266779009358 active site 266779009359 catalytic site [active] 266779009360 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 266779009361 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 266779009362 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 266779009363 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 266779009364 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 266779009365 active site 266779009366 homodimer interface [polypeptide binding]; other site 266779009367 catalytic site [active] 266779009368 acceptor binding site [chemical binding]; other site 266779009369 UreD urease accessory protein; Region: UreD; cl00530 266779009370 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 266779009371 alpha-gamma subunit interface [polypeptide binding]; other site 266779009372 beta-gamma subunit interface [polypeptide binding]; other site 266779009373 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 266779009374 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 266779009375 gamma-beta subunit interface [polypeptide binding]; other site 266779009376 alpha-beta subunit interface [polypeptide binding]; other site 266779009377 urease subunit alpha; Reviewed; Region: ureC; PRK13207 266779009378 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 266779009379 subunit interactions [polypeptide binding]; other site 266779009380 active site 266779009381 flap region; other site 266779009382 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 266779009383 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 266779009384 dimer interface [polypeptide binding]; other site 266779009385 catalytic residues [active] 266779009386 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 266779009387 UreF; Region: UreF; pfam01730 266779009388 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266779009389 AAA domain; Region: AAA_18; pfam13238 266779009390 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 266779009391 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266779009392 putative ADP-binding pocket [chemical binding]; other site 266779009393 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 266779009394 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 266779009395 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 266779009396 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 266779009397 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 266779009398 active site 266779009399 Substrate binding site; other site 266779009400 Mg++ binding site; other site 266779009401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 266779009402 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 266779009403 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266779009404 catalytic core [active] 266779009405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266779009406 Coenzyme A binding pocket [chemical binding]; other site 266779009407 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 266779009408 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 266779009409 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 266779009410 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 266779009411 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266779009412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779009413 S-adenosylmethionine binding site [chemical binding]; other site 266779009414 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 266779009415 substrate binding site [chemical binding]; other site 266779009416 THF binding site; other site 266779009417 zinc-binding site [ion binding]; other site 266779009418 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 266779009419 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 266779009420 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 266779009421 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 266779009422 active site 266779009423 DNA binding site [nucleotide binding] 266779009424 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 266779009425 DNA binding site [nucleotide binding] 266779009426 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 266779009427 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 266779009428 THF binding site; other site 266779009429 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 266779009430 substrate binding site [chemical binding]; other site 266779009431 THF binding site; other site 266779009432 zinc-binding site [ion binding]; other site 266779009433 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 266779009434 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 266779009435 dimer interface [polypeptide binding]; other site 266779009436 putative radical transfer pathway; other site 266779009437 diiron center [ion binding]; other site 266779009438 tyrosyl radical; other site 266779009439 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 266779009440 ATP cone domain; Region: ATP-cone; pfam03477 266779009441 ATP cone domain; Region: ATP-cone; pfam03477 266779009442 Class I ribonucleotide reductase; Region: RNR_I; cd01679 266779009443 active site 266779009444 dimer interface [polypeptide binding]; other site 266779009445 catalytic residues [active] 266779009446 effector binding site; other site 266779009447 R2 peptide binding site; other site 266779009448 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 266779009449 nucleotide binding site [chemical binding]; other site 266779009450 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266779009451 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266779009452 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266779009453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779009454 dimer interface [polypeptide binding]; other site 266779009455 conserved gate region; other site 266779009456 putative PBP binding loops; other site 266779009457 ABC-ATPase subunit interface; other site 266779009458 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266779009459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779009460 dimer interface [polypeptide binding]; other site 266779009461 conserved gate region; other site 266779009462 putative PBP binding loops; other site 266779009463 ABC-ATPase subunit interface; other site 266779009464 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266779009465 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266779009466 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266779009467 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266779009468 Walker A/P-loop; other site 266779009469 ATP binding site [chemical binding]; other site 266779009470 Q-loop/lid; other site 266779009471 ABC transporter signature motif; other site 266779009472 Walker B; other site 266779009473 D-loop; other site 266779009474 H-loop/switch region; other site 266779009475 TOBE domain; Region: TOBE_2; pfam08402 266779009476 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 266779009477 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 266779009478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779009479 LysR family transcriptional regulator; Provisional; Region: PRK14997 266779009480 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266779009481 putative effector binding pocket; other site 266779009482 dimerization interface [polypeptide binding]; other site 266779009483 amidase; Provisional; Region: PRK08310 266779009484 indole-3-acetamide amidohydrolase; Region: PLN02722 266779009485 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 266779009486 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 266779009487 active site 266779009488 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266779009489 dimer interface [polypeptide binding]; other site 266779009490 catalytic residues [active] 266779009491 substrate binding site [chemical binding]; other site 266779009492 Predicted acetyltransferase [General function prediction only]; Region: COG3153 266779009493 Coenzyme A binding pocket [chemical binding]; other site 266779009494 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266779009495 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266779009496 aspartate aminotransferase; Provisional; Region: PRK05764 266779009497 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266779009498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779009499 homodimer interface [polypeptide binding]; other site 266779009500 catalytic residue [active] 266779009501 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 266779009502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779009503 Walker A/P-loop; other site 266779009504 ATP binding site [chemical binding]; other site 266779009505 Q-loop/lid; other site 266779009506 ABC transporter signature motif; other site 266779009507 Walker B; other site 266779009508 D-loop; other site 266779009509 H-loop/switch region; other site 266779009510 TOBE domain; Region: TOBE; cl01440 266779009511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779009512 dimer interface [polypeptide binding]; other site 266779009513 conserved gate region; other site 266779009514 putative PBP binding loops; other site 266779009515 ABC-ATPase subunit interface; other site 266779009516 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 266779009517 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266779009518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 266779009519 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 266779009520 putative metal binding site [ion binding]; other site 266779009521 ferrochelatase; Reviewed; Region: hemH; PRK00035 266779009522 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 266779009523 C-terminal domain interface [polypeptide binding]; other site 266779009524 active site 266779009525 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 266779009526 active site 266779009527 N-terminal domain interface [polypeptide binding]; other site 266779009528 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 266779009529 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 266779009530 active site 266779009531 metal binding site [ion binding]; metal-binding site 266779009532 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 266779009533 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 266779009534 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266779009535 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 266779009536 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 266779009537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 266779009538 aminodeoxychorismate synthase; Provisional; Region: PRK07508 266779009539 chorismate binding enzyme; Region: Chorismate_bind; cl10555 266779009540 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 266779009541 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 266779009542 active site 266779009543 Zn binding site [ion binding]; other site 266779009544 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266779009545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779009546 active site 266779009547 phosphorylation site [posttranslational modification] 266779009548 intermolecular recognition site; other site 266779009549 dimerization interface [polypeptide binding]; other site 266779009550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779009551 Walker A motif; other site 266779009552 ATP binding site [chemical binding]; other site 266779009553 Walker B motif; other site 266779009554 arginine finger; other site 266779009555 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266779009556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 266779009557 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 266779009558 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 266779009559 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 266779009560 active site 266779009561 intersubunit interface [polypeptide binding]; other site 266779009562 catalytic residue [active] 266779009563 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 266779009564 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266779009565 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 266779009566 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 266779009567 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 266779009568 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 266779009569 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 266779009570 putative active site [active] 266779009571 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 266779009572 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 266779009573 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 266779009574 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 266779009575 active site 266779009576 tetramer interface; other site 266779009577 Transglycosylase SLT domain; Region: SLT_2; pfam13406 266779009578 murein hydrolase B; Provisional; Region: PRK10760; cl17906 266779009579 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266779009580 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 266779009581 active site 266779009582 catalytic triad [active] 266779009583 oxyanion hole [active] 266779009584 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 266779009585 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266779009586 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 266779009587 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 266779009588 active site 266779009589 dimer interface [polypeptide binding]; other site 266779009590 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 266779009591 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 266779009592 active site 266779009593 FMN binding site [chemical binding]; other site 266779009594 substrate binding site [chemical binding]; other site 266779009595 3Fe-4S cluster binding site [ion binding]; other site 266779009596 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 266779009597 domain interface; other site 266779009598 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 266779009599 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 266779009600 tetramer interface [polypeptide binding]; other site 266779009601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779009602 catalytic residue [active] 266779009603 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266779009604 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 266779009605 putative dimer interface [polypeptide binding]; other site 266779009606 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 266779009607 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266779009608 TAP-like protein; Region: Abhydrolase_4; pfam08386 266779009609 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 266779009610 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 266779009611 active site 266779009612 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 266779009613 Response regulator receiver domain; Region: Response_reg; pfam00072 266779009614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779009615 active site 266779009616 phosphorylation site [posttranslational modification] 266779009617 intermolecular recognition site; other site 266779009618 dimerization interface [polypeptide binding]; other site 266779009619 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266779009620 active site 266779009621 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 266779009622 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 266779009623 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 266779009624 putative active site [active] 266779009625 putative metal binding site [ion binding]; other site 266779009626 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 266779009627 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 266779009628 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 266779009629 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266779009630 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 266779009631 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 266779009632 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 266779009633 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266779009634 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 266779009635 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 266779009636 Walker A/P-loop; other site 266779009637 ATP binding site [chemical binding]; other site 266779009638 Q-loop/lid; other site 266779009639 ABC transporter signature motif; other site 266779009640 Walker B; other site 266779009641 D-loop; other site 266779009642 H-loop/switch region; other site 266779009643 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266779009644 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 266779009645 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 266779009646 substrate binding site; other site 266779009647 tetramer interface; other site 266779009648 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 266779009649 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 266779009650 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 266779009651 NAD binding site [chemical binding]; other site 266779009652 substrate binding site [chemical binding]; other site 266779009653 homodimer interface [polypeptide binding]; other site 266779009654 active site 266779009655 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 266779009656 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 266779009657 NADP binding site [chemical binding]; other site 266779009658 active site 266779009659 putative substrate binding site [chemical binding]; other site 266779009660 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 266779009661 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 266779009662 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266779009663 active site 266779009664 metal binding site [ion binding]; metal-binding site 266779009665 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 266779009666 30S subunit binding site; other site 266779009667 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266779009668 DNA-binding site [nucleotide binding]; DNA binding site 266779009669 RNA-binding motif; other site 266779009670 Domain of unknown function (DUF427); Region: DUF427; pfam04248 266779009671 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 266779009672 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 266779009673 active site 266779009674 DNA binding site [nucleotide binding] 266779009675 Int/Topo IB signature motif; other site 266779009676 catalytic residues [active] 266779009677 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 266779009678 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266779009679 NAD binding site [chemical binding]; other site 266779009680 putative substrate binding site 2 [chemical binding]; other site 266779009681 putative substrate binding site 1 [chemical binding]; other site 266779009682 active site 266779009683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 266779009684 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 266779009685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 266779009686 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 266779009687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 266779009688 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266779009689 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 266779009690 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266779009691 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266779009692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266779009693 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266779009694 NAD(P) binding site [chemical binding]; other site 266779009695 active site 266779009696 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266779009697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266779009698 NAD(P) binding site [chemical binding]; other site 266779009699 active site 266779009700 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 266779009701 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 266779009702 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 266779009703 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 266779009704 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266779009705 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269 266779009706 putative NAD(P) binding site [chemical binding]; other site 266779009707 catalytic Zn binding site [ion binding]; other site 266779009708 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266779009709 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266779009710 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266779009711 FOG: CBS domain [General function prediction only]; Region: COG0517 266779009712 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 266779009713 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266779009714 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 266779009715 D-pathway; other site 266779009716 Putative ubiquinol binding site [chemical binding]; other site 266779009717 Low-spin heme (heme b) binding site [chemical binding]; other site 266779009718 Putative water exit pathway; other site 266779009719 Binuclear center (heme o3/CuB) [ion binding]; other site 266779009720 K-pathway; other site 266779009721 Putative proton exit pathway; other site 266779009722 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 266779009723 Subunit I/III interface [polypeptide binding]; other site 266779009724 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 266779009725 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266779009726 Cytochrome c; Region: Cytochrom_C; pfam00034 266779009727 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266779009728 Cytochrome c; Region: Cytochrom_C; cl11414 266779009729 Cytochrome c; Region: Cytochrom_C; cl11414 266779009730 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 266779009731 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266779009732 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266779009733 HlyD family secretion protein; Region: HlyD_3; pfam13437 266779009734 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266779009735 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 266779009736 putative active site [active] 266779009737 putative catalytic site [active] 266779009738 classical (c) SDRs; Region: SDR_c; cd05233 266779009739 NAD(P) binding site [chemical binding]; other site 266779009740 active site 266779009741 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 266779009742 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266779009743 TPR motif; other site 266779009744 TPR repeat; Region: TPR_11; pfam13414 266779009745 binding surface 266779009746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266779009747 binding surface 266779009748 TPR motif; other site 266779009749 TPR repeat; Region: TPR_11; pfam13414 266779009750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266779009751 binding surface 266779009752 TPR motif; other site 266779009753 Protein of unknown function (DUF992); Region: DUF992; pfam06186 266779009754 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 266779009755 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 266779009756 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 266779009757 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 266779009758 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 266779009759 ligand binding site [chemical binding]; other site 266779009760 homodimer interface [polypeptide binding]; other site 266779009761 NAD(P) binding site [chemical binding]; other site 266779009762 trimer interface B [polypeptide binding]; other site 266779009763 trimer interface A [polypeptide binding]; other site 266779009764 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 266779009765 Protein of unknown function (DUF3096); Region: DUF3096; pfam11295 266779009766 PAS domain; Region: PAS; smart00091 266779009767 PAS fold; Region: PAS_7; pfam12860 266779009768 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266779009769 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266779009770 metal binding site [ion binding]; metal-binding site 266779009771 active site 266779009772 I-site; other site 266779009773 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266779009774 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 266779009775 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 266779009776 dimer interface [polypeptide binding]; other site 266779009777 PYR/PP interface [polypeptide binding]; other site 266779009778 TPP binding site [chemical binding]; other site 266779009779 substrate binding site [chemical binding]; other site 266779009780 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 266779009781 TPP-binding site; other site 266779009782 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 266779009783 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 266779009784 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 266779009785 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 266779009786 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 266779009787 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266779009788 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 266779009789 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 266779009790 catalytic triad [active] 266779009791 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266779009792 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 266779009793 putative ligand binding site [chemical binding]; other site 266779009794 NAD binding site [chemical binding]; other site 266779009795 catalytic site [active] 266779009796 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 266779009797 N- and C-terminal domain interface [polypeptide binding]; other site 266779009798 D-xylulose kinase; Region: XylB; TIGR01312 266779009799 active site 266779009800 MgATP binding site [chemical binding]; other site 266779009801 catalytic site [active] 266779009802 metal binding site [ion binding]; metal-binding site 266779009803 xylulose binding site [chemical binding]; other site 266779009804 homodimer interface [polypeptide binding]; other site 266779009805 xylose isomerase; Provisional; Region: PRK05474 266779009806 xylose isomerase; Region: xylose_isom_A; TIGR02630 266779009807 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 266779009808 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266779009809 Bacterial transcriptional regulator; Region: IclR; pfam01614 266779009810 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 266779009811 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 266779009812 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 266779009813 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266779009814 dimer interface [polypeptide binding]; other site 266779009815 active site 266779009816 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 266779009817 oligomeric interface; other site 266779009818 putative active site [active] 266779009819 homodimer interface [polypeptide binding]; other site 266779009820 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 266779009821 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266779009822 nucleoside/Zn binding site; other site 266779009823 dimer interface [polypeptide binding]; other site 266779009824 catalytic motif [active] 266779009825 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 266779009826 ureidoglycolate hydrolase; Provisional; Region: PRK03606 266779009827 hypothetical protein; Provisional; Region: PRK11171 266779009828 Cupin domain; Region: Cupin_2; pfam07883 266779009829 Cupin domain; Region: Cupin_2; cl17218 266779009830 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 266779009831 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 266779009832 active site 266779009833 catalytic site [active] 266779009834 tetramer interface [polypeptide binding]; other site 266779009835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 266779009836 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 266779009837 active site 266779009838 homotetramer interface [polypeptide binding]; other site 266779009839 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 266779009840 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266779009841 catalytic loop [active] 266779009842 iron binding site [ion binding]; other site 266779009843 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266779009844 FAD binding domain; Region: FAD_binding_4; pfam01565 266779009845 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 266779009846 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 266779009847 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266779009848 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266779009849 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266779009850 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 266779009851 XdhC Rossmann domain; Region: XdhC_C; pfam13478 266779009852 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779009853 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779009854 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266779009855 putative effector binding pocket; other site 266779009856 dimerization interface [polypeptide binding]; other site 266779009857 Predicted membrane protein [Function unknown]; Region: COG3748 266779009858 Protein of unknown function (DUF989); Region: DUF989; pfam06181 266779009859 Cytochrome c; Region: Cytochrom_C; pfam00034 266779009860 guanine deaminase; Provisional; Region: PRK09228 266779009861 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 266779009862 active site 266779009863 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 266779009864 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 266779009865 MOFRL family; Region: MOFRL; pfam05161 266779009866 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 266779009867 Fe-S cluster binding site [ion binding]; other site 266779009868 active site 266779009869 FOG: WD40 repeat [General function prediction only]; Region: COG2319 266779009870 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 266779009871 structural tetrad; other site 266779009872 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 266779009873 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 266779009874 P-loop, Walker A motif; other site 266779009875 Base recognition motif; other site 266779009876 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 266779009877 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 266779009878 putative active site [active] 266779009879 Creatinine amidohydrolase; Region: Creatininase; pfam02633 266779009880 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266779009881 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779009882 putative DNA binding site [nucleotide binding]; other site 266779009883 putative Zn2+ binding site [ion binding]; other site 266779009884 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266779009885 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266779009886 DNA binding site [nucleotide binding] 266779009887 domain linker motif; other site 266779009888 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 266779009889 putative dimerization interface [polypeptide binding]; other site 266779009890 putative ligand binding site [chemical binding]; other site 266779009891 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779009892 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779009893 LysR substrate binding domain; Region: LysR_substrate; pfam03466 266779009894 dimerization interface [polypeptide binding]; other site 266779009895 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 266779009896 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 266779009897 DNA binding residues [nucleotide binding] 266779009898 dimer interface [polypeptide binding]; other site 266779009899 putative metal binding site [ion binding]; other site 266779009900 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 266779009901 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266779009902 metal-binding site [ion binding] 266779009903 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266779009904 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 266779009905 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266779009906 ABC-ATPase subunit interface; other site 266779009907 dimer interface [polypeptide binding]; other site 266779009908 putative PBP binding regions; other site 266779009909 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 266779009910 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266779009911 ABC-ATPase subunit interface; other site 266779009912 dimer interface [polypeptide binding]; other site 266779009913 putative PBP binding regions; other site 266779009914 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 266779009915 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 266779009916 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 266779009917 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 266779009918 intersubunit interface [polypeptide binding]; other site 266779009919 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266779009920 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266779009921 DNA binding site [nucleotide binding] 266779009922 domain linker motif; other site 266779009923 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 266779009924 ligand binding site [chemical binding]; other site 266779009925 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266779009926 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266779009927 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266779009928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266779009929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779009930 conserved gate region; other site 266779009931 dimer interface [polypeptide binding]; other site 266779009932 putative PBP binding loops; other site 266779009933 ABC-ATPase subunit interface; other site 266779009934 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266779009935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779009936 dimer interface [polypeptide binding]; other site 266779009937 conserved gate region; other site 266779009938 putative PBP binding loops; other site 266779009939 ABC-ATPase subunit interface; other site 266779009940 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266779009941 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266779009942 Walker A/P-loop; other site 266779009943 ATP binding site [chemical binding]; other site 266779009944 Q-loop/lid; other site 266779009945 ABC transporter signature motif; other site 266779009946 Walker B; other site 266779009947 D-loop; other site 266779009948 H-loop/switch region; other site 266779009949 TOBE domain; Region: TOBE_2; pfam08402 266779009950 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 266779009951 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266779009952 FeS/SAM binding site; other site 266779009953 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779009954 dimerization interface [polypeptide binding]; other site 266779009955 putative DNA binding site [nucleotide binding]; other site 266779009956 putative Zn2+ binding site [ion binding]; other site 266779009957 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 266779009958 putative hydrophobic ligand binding site [chemical binding]; other site 266779009959 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266779009960 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 266779009961 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 266779009962 active site 266779009963 dimer interface [polypeptide binding]; other site 266779009964 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 266779009965 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 266779009966 dimer interface [polypeptide binding]; other site 266779009967 active site 266779009968 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266779009969 dimer interface [polypeptide binding]; other site 266779009970 active site 266779009971 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 266779009972 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 266779009973 putative active site [active] 266779009974 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 266779009975 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 266779009976 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266779009977 zinc binding site [ion binding]; other site 266779009978 putative ligand binding site [chemical binding]; other site 266779009979 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 266779009980 TM-ABC transporter signature motif; other site 266779009981 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 266779009982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779009983 Walker A/P-loop; other site 266779009984 ATP binding site [chemical binding]; other site 266779009985 Q-loop/lid; other site 266779009986 ABC transporter signature motif; other site 266779009987 Walker B; other site 266779009988 D-loop; other site 266779009989 H-loop/switch region; other site 266779009990 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266779009991 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 266779009992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779009993 S-adenosylmethionine binding site [chemical binding]; other site 266779009994 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 266779009995 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 266779009996 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 266779009997 Chain length determinant protein; Region: Wzz; cl15801 266779009998 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 266779009999 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 266779010000 TraB family; Region: TraB; cl12050 266779010001 O-Antigen ligase; Region: Wzy_C; pfam04932 266779010002 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 266779010003 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 266779010004 putative active site [active] 266779010005 putative metal binding site [ion binding]; other site 266779010006 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266779010007 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 266779010008 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266779010009 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 266779010010 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266779010011 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266779010012 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266779010013 active site 266779010014 NAD synthetase; Reviewed; Region: nadE; PRK00876 266779010015 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 266779010016 homodimer interface [polypeptide binding]; other site 266779010017 NAD binding pocket [chemical binding]; other site 266779010018 ATP binding pocket [chemical binding]; other site 266779010019 Mg binding site [ion binding]; other site 266779010020 active-site loop [active] 266779010021 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266779010022 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266779010023 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 266779010024 acyl-activating enzyme (AAE) consensus motif; other site 266779010025 acyl-activating enzyme (AAE) consensus motif; other site 266779010026 putative AMP binding site [chemical binding]; other site 266779010027 putative active site [active] 266779010028 putative CoA binding site [chemical binding]; other site 266779010029 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 266779010030 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 266779010031 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 266779010032 active site 266779010033 dimer interface [polypeptide binding]; other site 266779010034 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 266779010035 Ligand Binding Site [chemical binding]; other site 266779010036 Molecular Tunnel; other site 266779010037 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 266779010038 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 266779010039 dimer interface [polypeptide binding]; other site 266779010040 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 266779010041 active site 266779010042 Fe binding site [ion binding]; other site 266779010043 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266779010044 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779010045 putative DNA binding site [nucleotide binding]; other site 266779010046 putative Zn2+ binding site [ion binding]; other site 266779010047 AsnC family; Region: AsnC_trans_reg; pfam01037 266779010048 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266779010049 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266779010050 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 266779010051 putative substrate binding region [chemical binding]; other site 266779010052 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266779010053 substrate binding pocket [chemical binding]; other site 266779010054 membrane-bound complex binding site; other site 266779010055 hinge residues; other site 266779010056 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 266779010057 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 266779010058 Trp docking motif [polypeptide binding]; other site 266779010059 active site 266779010060 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266779010061 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 266779010062 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266779010063 substrate binding pocket [chemical binding]; other site 266779010064 membrane-bound complex binding site; other site 266779010065 hinge residues; other site 266779010066 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266779010067 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266779010068 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266779010069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779010070 Walker A/P-loop; other site 266779010071 ATP binding site [chemical binding]; other site 266779010072 Q-loop/lid; other site 266779010073 ABC transporter signature motif; other site 266779010074 Walker B; other site 266779010075 D-loop; other site 266779010076 H-loop/switch region; other site 266779010077 Cytochrome C' Region: Cytochrom_C_2; cl01610 266779010078 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266779010079 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266779010080 DctM-like transporters; Region: DctM; pfam06808 266779010081 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 266779010082 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 266779010083 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266779010084 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 266779010085 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 266779010086 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 266779010087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266779010088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779010089 active site 266779010090 phosphorylation site [posttranslational modification] 266779010091 intermolecular recognition site; other site 266779010092 dimerization interface [polypeptide binding]; other site 266779010093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266779010094 DNA binding site [nucleotide binding] 266779010095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266779010096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266779010097 dimerization interface [polypeptide binding]; other site 266779010098 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 266779010099 dimer interface [polypeptide binding]; other site 266779010100 phosphorylation site [posttranslational modification] 266779010101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779010102 ATP binding site [chemical binding]; other site 266779010103 Mg2+ binding site [ion binding]; other site 266779010104 G-X-G motif; other site 266779010105 benzoate transport; Region: 2A0115; TIGR00895 266779010106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779010107 putative substrate translocation pore; other site 266779010108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779010109 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266779010110 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 266779010111 Porin subfamily; Region: Porin_2; pfam02530 266779010112 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 266779010113 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266779010114 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266779010115 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266779010116 Cytochrome c2 [Energy production and conversion]; Region: COG3474 266779010117 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266779010118 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266779010119 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 266779010120 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266779010121 PYR/PP interface [polypeptide binding]; other site 266779010122 dimer interface [polypeptide binding]; other site 266779010123 TPP binding site [chemical binding]; other site 266779010124 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266779010125 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 266779010126 TPP-binding site [chemical binding]; other site 266779010127 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266779010128 Pseudomonas putida aldehyde dehydrogenase PsfA (ACA09737)-like; Region: ALDH_PsfA-ACA09737; cd07120 266779010129 NAD(P) binding site [chemical binding]; other site 266779010130 catalytic residues [active] 266779010131 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 266779010132 hypothetical protein; Provisional; Region: PRK07538 266779010133 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266779010134 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 266779010135 Flavoprotein; Region: Flavoprotein; pfam02441 266779010136 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266779010137 MarR family; Region: MarR_2; pfam12802 266779010138 MarR family; Region: MarR_2; cl17246 266779010139 MarR family; Region: MarR_2; cl17246 266779010140 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266779010141 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266779010142 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266779010143 NAD(P) binding site [chemical binding]; other site 266779010144 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 266779010145 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266779010146 active site 266779010147 metal binding site [ion binding]; metal-binding site 266779010148 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 266779010149 active site 266779010150 metal binding site [ion binding]; metal-binding site 266779010151 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266779010152 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266779010153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779010154 DNA-binding site [nucleotide binding]; DNA binding site 266779010155 FCD domain; Region: FCD; pfam07729 266779010156 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266779010157 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 266779010158 active site 266779010159 metal binding site [ion binding]; metal-binding site 266779010160 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 266779010161 active site 266779010162 metal binding site [ion binding]; metal-binding site 266779010163 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266779010164 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 266779010165 DctM-like transporters; Region: DctM; pfam06808 266779010166 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 266779010167 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266779010168 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266779010169 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 266779010170 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266779010171 PYR/PP interface [polypeptide binding]; other site 266779010172 dimer interface [polypeptide binding]; other site 266779010173 TPP binding site [chemical binding]; other site 266779010174 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266779010175 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 266779010176 TPP-binding site [chemical binding]; other site 266779010177 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266779010178 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266779010179 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266779010180 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266779010181 active site 266779010182 catalytic tetrad [active] 266779010183 short chain dehydrogenase; Provisional; Region: PRK06180 266779010184 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266779010185 NADP binding site [chemical binding]; other site 266779010186 active site 266779010187 steroid binding site; other site 266779010188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779010189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779010190 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266779010191 putative effector binding pocket; other site 266779010192 putative dimerization interface [polypeptide binding]; other site 266779010193 DJ-1 family protein; Region: not_thiJ; TIGR01383 266779010194 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 266779010195 conserved cys residue [active] 266779010196 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 266779010197 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266779010198 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 266779010199 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266779010200 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266779010201 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266779010202 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266779010203 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 266779010204 NAD(P) binding site [chemical binding]; other site 266779010205 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 266779010206 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266779010207 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266779010208 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266779010209 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266779010210 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266779010211 active site 266779010212 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266779010213 classical (c) SDRs; Region: SDR_c; cd05233 266779010214 NAD(P) binding site [chemical binding]; other site 266779010215 active site 266779010216 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266779010217 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 266779010218 substrate binding site [chemical binding]; other site 266779010219 oxyanion hole (OAH) forming residues; other site 266779010220 trimer interface [polypeptide binding]; other site 266779010221 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266779010222 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 266779010223 acyl-activating enzyme (AAE) consensus motif; other site 266779010224 putative AMP binding site [chemical binding]; other site 266779010225 putative active site [active] 266779010226 putative CoA binding site [chemical binding]; other site 266779010227 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266779010228 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266779010229 substrate binding site [chemical binding]; other site 266779010230 oxyanion hole (OAH) forming residues; other site 266779010231 trimer interface [polypeptide binding]; other site 266779010232 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266779010233 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266779010234 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 266779010235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779010236 Walker A motif; other site 266779010237 ATP binding site [chemical binding]; other site 266779010238 Walker B motif; other site 266779010239 arginine finger; other site 266779010240 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266779010241 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 266779010242 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 266779010243 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 266779010244 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 266779010245 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266779010246 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266779010247 short chain dehydrogenase; Provisional; Region: PRK06125 266779010248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266779010249 NAD(P) binding site [chemical binding]; other site 266779010250 active site 266779010251 NIPSNAP; Region: NIPSNAP; pfam07978 266779010252 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266779010253 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266779010254 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266779010255 Walker A/P-loop; other site 266779010256 ATP binding site [chemical binding]; other site 266779010257 Q-loop/lid; other site 266779010258 ABC transporter signature motif; other site 266779010259 Walker B; other site 266779010260 D-loop; other site 266779010261 H-loop/switch region; other site 266779010262 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266779010263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779010264 dimer interface [polypeptide binding]; other site 266779010265 conserved gate region; other site 266779010266 putative PBP binding loops; other site 266779010267 ABC-ATPase subunit interface; other site 266779010268 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266779010269 NMT1/THI5 like; Region: NMT1; pfam09084 266779010270 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266779010271 NMT1-like family; Region: NMT1_2; pfam13379 266779010272 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266779010273 classical (c) SDRs; Region: SDR_c; cd05233 266779010274 NAD(P) binding site [chemical binding]; other site 266779010275 active site 266779010276 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 266779010277 classical (c) SDRs; Region: SDR_c; cd05233 266779010278 NAD(P) binding site [chemical binding]; other site 266779010279 active site 266779010280 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266779010281 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266779010282 Bacterial transcriptional regulator; Region: IclR; pfam01614 266779010283 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 266779010284 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 266779010285 active site 266779010286 Coenzyme A transferase; Region: CoA_trans; smart00882 266779010287 Coenzyme A transferase; Region: CoA_trans; cl17247 266779010288 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266779010289 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266779010290 Predicted membrane protein [Function unknown]; Region: COG2855 266779010291 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 266779010292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779010293 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 266779010294 putative dimerization interface [polypeptide binding]; other site 266779010295 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 266779010296 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266779010297 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 266779010298 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266779010299 membrane-bound complex binding site; other site 266779010300 hinge residues; other site 266779010301 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779010302 DNA-binding site [nucleotide binding]; DNA binding site 266779010303 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 266779010304 UTRA domain; Region: UTRA; pfam07702 266779010305 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 266779010306 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266779010307 active sites [active] 266779010308 tetramer interface [polypeptide binding]; other site 266779010309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779010310 dimer interface [polypeptide binding]; other site 266779010311 conserved gate region; other site 266779010312 ABC-ATPase subunit interface; other site 266779010313 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 266779010314 ABC-ATPase subunit interface; other site 266779010315 putative PBP binding loops; other site 266779010316 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 266779010317 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 266779010318 Walker A/P-loop; other site 266779010319 ATP binding site [chemical binding]; other site 266779010320 Q-loop/lid; other site 266779010321 ABC transporter signature motif; other site 266779010322 Walker B; other site 266779010323 D-loop; other site 266779010324 H-loop/switch region; other site 266779010325 HutD; Region: HutD; pfam05962 266779010326 urocanate hydratase; Provisional; Region: PRK05414 266779010327 N-formylglutamate amidohydrolase; Region: FGase; cl01522 266779010328 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266779010329 active sites [active] 266779010330 tetramer interface [polypeptide binding]; other site 266779010331 imidazolonepropionase; Validated; Region: PRK09356 266779010332 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 266779010333 active site 266779010334 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 266779010335 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 266779010336 active site 266779010337 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779010338 DNA-binding site [nucleotide binding]; DNA binding site 266779010339 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 266779010340 UTRA domain; Region: UTRA; pfam07702 266779010341 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 266779010342 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 266779010343 Peptidase family M23; Region: Peptidase_M23; pfam01551 266779010344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266779010345 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266779010346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 266779010347 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 266779010348 Clp amino terminal domain; Region: Clp_N; pfam02861 266779010349 Clp amino terminal domain; Region: Clp_N; pfam02861 266779010350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779010351 Walker A motif; other site 266779010352 ATP binding site [chemical binding]; other site 266779010353 Walker B motif; other site 266779010354 arginine finger; other site 266779010355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779010356 Walker A motif; other site 266779010357 ATP binding site [chemical binding]; other site 266779010358 Walker B motif; other site 266779010359 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 266779010360 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 266779010361 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 266779010362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779010363 S-adenosylmethionine binding site [chemical binding]; other site 266779010364 peptide chain release factor 1; Validated; Region: prfA; PRK00591 266779010365 This domain is found in peptide chain release factors; Region: PCRF; smart00937 266779010366 RF-1 domain; Region: RF-1; pfam00472 266779010367 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 266779010368 GAF domain; Region: GAF; pfam01590 266779010369 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 266779010370 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 266779010371 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 266779010372 aspartate kinase; Reviewed; Region: PRK06635 266779010373 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 266779010374 putative nucleotide binding site [chemical binding]; other site 266779010375 putative catalytic residues [active] 266779010376 putative Mg ion binding site [ion binding]; other site 266779010377 putative aspartate binding site [chemical binding]; other site 266779010378 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 266779010379 putative allosteric regulatory site; other site 266779010380 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 266779010381 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 266779010382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779010383 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 266779010384 nitrilase; Region: PLN02798 266779010385 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 266779010386 putative active site [active] 266779010387 catalytic triad [active] 266779010388 dimer interface [polypeptide binding]; other site 266779010389 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 266779010390 GSH binding site [chemical binding]; other site 266779010391 catalytic residues [active] 266779010392 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 266779010393 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266779010394 active site 266779010395 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 266779010396 Methyltransferase domain; Region: Methyltransf_11; pfam08241 266779010397 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 266779010398 active site 266779010399 8-oxo-dGMP binding site [chemical binding]; other site 266779010400 nudix motif; other site 266779010401 metal binding site [ion binding]; metal-binding site 266779010402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266779010403 Coenzyme A binding pocket [chemical binding]; other site 266779010404 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 266779010405 heterotetramer interface [polypeptide binding]; other site 266779010406 active site pocket [active] 266779010407 cleavage site 266779010408 SurA N-terminal domain; Region: SurA_N_3; cl07813 266779010409 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 266779010410 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 266779010411 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 266779010412 ATP binding site [chemical binding]; other site 266779010413 putative Mg++ binding site [ion binding]; other site 266779010414 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 266779010415 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 266779010416 nucleotide binding region [chemical binding]; other site 266779010417 ATP-binding site [chemical binding]; other site 266779010418 SEC-C motif; Region: SEC-C; pfam02810 266779010419 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 266779010420 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 266779010421 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 266779010422 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 266779010423 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 266779010424 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 266779010425 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 266779010426 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 266779010427 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266779010428 active site 266779010429 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266779010430 endonuclease III; Region: ENDO3c; smart00478 266779010431 minor groove reading motif; other site 266779010432 helix-hairpin-helix signature motif; other site 266779010433 substrate binding pocket [chemical binding]; other site 266779010434 active site 266779010435 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 266779010436 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 266779010437 active site 266779010438 HIGH motif; other site 266779010439 nucleotide binding site [chemical binding]; other site 266779010440 active site 266779010441 KMSKS motif; other site 266779010442 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266779010443 EamA-like transporter family; Region: EamA; pfam00892 266779010444 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 266779010445 short chain dehydrogenase; Provisional; Region: PRK05993 266779010446 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266779010447 NADP binding site [chemical binding]; other site 266779010448 active site 266779010449 steroid binding site; other site 266779010450 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 266779010451 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 266779010452 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 266779010453 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 266779010454 Ligand binding site [chemical binding]; other site 266779010455 Electron transfer flavoprotein domain; Region: ETF; pfam01012 266779010456 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 266779010457 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 266779010458 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 266779010459 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 266779010460 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266779010461 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266779010462 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 266779010463 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 266779010464 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266779010465 active site 266779010466 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 266779010467 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 266779010468 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266779010469 catalytic residues [active] 266779010470 argininosuccinate lyase; Provisional; Region: PRK00855 266779010471 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266779010472 active sites [active] 266779010473 tetramer interface [polypeptide binding]; other site 266779010474 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 266779010475 diaminopimelate decarboxylase; Region: lysA; TIGR01048 266779010476 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 266779010477 active site 266779010478 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266779010479 substrate binding site [chemical binding]; other site 266779010480 catalytic residues [active] 266779010481 dimer interface [polypeptide binding]; other site 266779010482 OpgC protein; Region: OpgC_C; pfam10129 266779010483 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266779010484 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 266779010485 Ligand binding site; other site 266779010486 DXD motif; other site 266779010487 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 266779010488 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 266779010489 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266779010490 MarR family; Region: MarR; pfam01047 266779010491 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 266779010492 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 266779010493 phosphate binding site [ion binding]; other site 266779010494 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266779010495 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266779010496 active site pocket [active] 266779010497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266779010498 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 266779010499 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266779010500 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266779010501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779010502 putative substrate translocation pore; other site 266779010503 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266779010504 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266779010505 active site 266779010506 catalytic tetrad [active] 266779010507 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779010508 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779010509 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480 266779010510 putative effector binding pocket; other site 266779010511 putative dimerization interface [polypeptide binding]; other site 266779010512 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 266779010513 DNA binding residues [nucleotide binding] 266779010514 dimerization interface [polypeptide binding]; other site 266779010515 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266779010516 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266779010517 metal binding site [ion binding]; metal-binding site 266779010518 putative dimer interface [polypeptide binding]; other site 266779010519 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 266779010520 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 266779010521 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 266779010522 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266779010523 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 266779010524 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 266779010525 CPxP motif; other site 266779010526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 266779010527 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 266779010528 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 266779010529 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 266779010530 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266779010531 active site 266779010532 DNA binding site [nucleotide binding] 266779010533 Int/Topo IB signature motif; other site 266779010534 shikimate kinase; Provisional; Region: PRK13946 266779010535 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266779010536 ADP binding site [chemical binding]; other site 266779010537 magnesium binding site [ion binding]; other site 266779010538 putative shikimate binding site; other site 266779010539 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 266779010540 active site 266779010541 dimer interface [polypeptide binding]; other site 266779010542 metal binding site [ion binding]; metal-binding site 266779010543 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 266779010544 Domain of unknown function DUF21; Region: DUF21; pfam01595 266779010545 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266779010546 Transporter associated domain; Region: CorC_HlyC; smart01091 266779010547 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 266779010548 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 266779010549 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266779010550 HSP70 interaction site [polypeptide binding]; other site 266779010551 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 266779010552 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 266779010553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 266779010554 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266779010555 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 266779010556 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 266779010557 metal ion-dependent adhesion site (MIDAS); other site 266779010558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 266779010559 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 266779010560 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 266779010561 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 266779010562 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779010563 dimerization interface [polypeptide binding]; other site 266779010564 putative DNA binding site [nucleotide binding]; other site 266779010565 putative Zn2+ binding site [ion binding]; other site 266779010566 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266779010567 putative hydrophobic ligand binding site [chemical binding]; other site 266779010568 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 266779010569 putative C-terminal domain interface [polypeptide binding]; other site 266779010570 putative GSH binding site (G-site) [chemical binding]; other site 266779010571 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266779010572 putative dimer interface [polypeptide binding]; other site 266779010573 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 266779010574 dimer interface [polypeptide binding]; other site 266779010575 N-terminal domain interface [polypeptide binding]; other site 266779010576 putative substrate binding pocket (H-site) [chemical binding]; other site 266779010577 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 266779010578 EamA-like transporter family; Region: EamA; pfam00892 266779010579 aromatic amino acid exporter; Provisional; Region: PRK11689 266779010580 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 266779010581 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266779010582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266779010583 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 266779010584 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 266779010585 FMN binding site [chemical binding]; other site 266779010586 substrate binding site [chemical binding]; other site 266779010587 putative catalytic residue [active] 266779010588 Homoserine O-succinyltransferase; Region: HTS; pfam04204 266779010589 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 266779010590 proposed active site lysine [active] 266779010591 conserved cys residue [active] 266779010592 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 266779010593 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266779010594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779010595 homodimer interface [polypeptide binding]; other site 266779010596 catalytic residue [active] 266779010597 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 266779010598 prephenate dehydrogenase; Validated; Region: PRK08507 266779010599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 266779010600 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 266779010601 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 266779010602 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 266779010603 putative active site pocket [active] 266779010604 dimerization interface [polypeptide binding]; other site 266779010605 putative catalytic residue [active] 266779010606 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 266779010607 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266779010608 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266779010609 putative acyl-acceptor binding pocket; other site 266779010610 Uncharacterized conserved protein [Function unknown]; Region: COG1434 266779010611 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 266779010612 putative active site [active] 266779010613 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 266779010614 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 266779010615 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 266779010616 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266779010617 Walker A/P-loop; other site 266779010618 ATP binding site [chemical binding]; other site 266779010619 Q-loop/lid; other site 266779010620 ABC transporter signature motif; other site 266779010621 Walker B; other site 266779010622 D-loop; other site 266779010623 H-loop/switch region; other site 266779010624 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266779010625 active site 266779010626 Response regulator receiver domain; Region: Response_reg; pfam00072 266779010627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779010628 active site 266779010629 phosphorylation site [posttranslational modification] 266779010630 intermolecular recognition site; other site 266779010631 dimerization interface [polypeptide binding]; other site 266779010632 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266779010633 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266779010634 ring oligomerisation interface [polypeptide binding]; other site 266779010635 ATP/Mg binding site [chemical binding]; other site 266779010636 stacking interactions; other site 266779010637 hinge regions; other site 266779010638 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266779010639 oligomerisation interface [polypeptide binding]; other site 266779010640 mobile loop; other site 266779010641 roof hairpin; other site 266779010642 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 266779010643 Protein of unknown function (DUF964); Region: DUF964; cl01483 266779010644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266779010645 Coenzyme A binding pocket [chemical binding]; other site 266779010646 Predicted esterase [General function prediction only]; Region: COG0400 266779010647 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 266779010648 Zn binding site [ion binding]; other site 266779010649 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 266779010650 Zn binding site [ion binding]; other site 266779010651 PRC-barrel domain; Region: PRC; pfam05239 266779010652 PRC-barrel domain; Region: PRC; pfam05239 266779010653 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 266779010654 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 266779010655 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 266779010656 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266779010657 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266779010658 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266779010659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779010660 active site 266779010661 phosphorylation site [posttranslational modification] 266779010662 intermolecular recognition site; other site 266779010663 dimerization interface [polypeptide binding]; other site 266779010664 RNA polymerase sigma factor; Provisional; Region: PRK12547 266779010665 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266779010666 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266779010667 DNA binding residues [nucleotide binding] 266779010668 two-component response regulator; Provisional; Region: PRK09191 266779010669 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 266779010670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779010671 active site 266779010672 phosphorylation site [posttranslational modification] 266779010673 intermolecular recognition site; other site 266779010674 dimerization interface [polypeptide binding]; other site 266779010675 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266779010676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779010677 Walker A/P-loop; other site 266779010678 ATP binding site [chemical binding]; other site 266779010679 Q-loop/lid; other site 266779010680 ABC transporter signature motif; other site 266779010681 Walker B; other site 266779010682 D-loop; other site 266779010683 H-loop/switch region; other site 266779010684 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266779010685 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266779010686 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266779010687 TM-ABC transporter signature motif; other site 266779010688 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 266779010689 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 266779010690 putative ligand binding site [chemical binding]; other site 266779010691 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266779010692 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 266779010693 nucleotide binding site [chemical binding]; other site 266779010694 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266779010695 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 266779010696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779010697 active site 266779010698 phosphorylation site [posttranslational modification] 266779010699 intermolecular recognition site; other site 266779010700 dimerization interface [polypeptide binding]; other site 266779010701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266779010702 DNA binding site [nucleotide binding] 266779010703 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 266779010704 PhoU domain; Region: PhoU; pfam01895 266779010705 PhoU domain; Region: PhoU; pfam01895 266779010706 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 266779010707 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 266779010708 Walker A/P-loop; other site 266779010709 ATP binding site [chemical binding]; other site 266779010710 Q-loop/lid; other site 266779010711 ABC transporter signature motif; other site 266779010712 Walker B; other site 266779010713 D-loop; other site 266779010714 H-loop/switch region; other site 266779010715 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 266779010716 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 266779010717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779010718 dimer interface [polypeptide binding]; other site 266779010719 conserved gate region; other site 266779010720 putative PBP binding loops; other site 266779010721 ABC-ATPase subunit interface; other site 266779010722 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 266779010723 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 266779010724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779010725 dimer interface [polypeptide binding]; other site 266779010726 conserved gate region; other site 266779010727 putative PBP binding loops; other site 266779010728 ABC-ATPase subunit interface; other site 266779010729 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 266779010730 Predicted membrane protein [Function unknown]; Region: COG1470 266779010731 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 266779010732 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266779010733 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266779010734 Walker A/P-loop; other site 266779010735 ATP binding site [chemical binding]; other site 266779010736 Q-loop/lid; other site 266779010737 ABC transporter signature motif; other site 266779010738 Walker B; other site 266779010739 D-loop; other site 266779010740 H-loop/switch region; other site 266779010741 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 266779010742 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 266779010743 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 266779010744 Protein of unknown function (DUF982); Region: DUF982; pfam06169 266779010745 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266779010746 active site 266779010747 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266779010748 catalytic tetrad [active] 266779010749 Predicted transcriptional regulators [Transcription]; Region: COG1725 266779010750 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779010751 DNA-binding site [nucleotide binding]; DNA binding site 266779010752 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 266779010753 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 266779010754 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779010755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779010756 dimer interface [polypeptide binding]; other site 266779010757 conserved gate region; other site 266779010758 putative PBP binding loops; other site 266779010759 ABC-ATPase subunit interface; other site 266779010760 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266779010761 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266779010762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779010763 dimer interface [polypeptide binding]; other site 266779010764 conserved gate region; other site 266779010765 putative PBP binding loops; other site 266779010766 ABC-ATPase subunit interface; other site 266779010767 Predicted deacylase [General function prediction only]; Region: COG3608 266779010768 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_5; cd06255 266779010769 putative active site [active] 266779010770 Zn binding site [ion binding]; other site 266779010771 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266779010772 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779010773 Walker A/P-loop; other site 266779010774 ATP binding site [chemical binding]; other site 266779010775 Q-loop/lid; other site 266779010776 ABC transporter signature motif; other site 266779010777 Walker B; other site 266779010778 D-loop; other site 266779010779 H-loop/switch region; other site 266779010780 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779010781 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 266779010782 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779010783 Walker A/P-loop; other site 266779010784 ATP binding site [chemical binding]; other site 266779010785 Q-loop/lid; other site 266779010786 ABC transporter signature motif; other site 266779010787 Walker B; other site 266779010788 D-loop; other site 266779010789 H-loop/switch region; other site 266779010790 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779010791 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266779010792 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 266779010793 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 266779010794 active site 266779010795 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 266779010796 Right handed beta helix region; Region: Beta_helix; pfam13229 266779010797 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266779010798 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266779010799 inhibitor site; inhibition site 266779010800 active site 266779010801 dimer interface [polypeptide binding]; other site 266779010802 catalytic residue [active] 266779010803 hypothetical protein; Validated; Region: PRK08245 266779010804 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 266779010805 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 266779010806 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266779010807 RNA binding surface [nucleotide binding]; other site 266779010808 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 266779010809 active site 266779010810 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266779010811 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266779010812 Walker A/P-loop; other site 266779010813 ATP binding site [chemical binding]; other site 266779010814 Q-loop/lid; other site 266779010815 ABC transporter signature motif; other site 266779010816 Walker B; other site 266779010817 D-loop; other site 266779010818 H-loop/switch region; other site 266779010819 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266779010820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779010821 dimer interface [polypeptide binding]; other site 266779010822 conserved gate region; other site 266779010823 putative PBP binding loops; other site 266779010824 ABC-ATPase subunit interface; other site 266779010825 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266779010826 substrate binding pocket [chemical binding]; other site 266779010827 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266779010828 membrane-bound complex binding site; other site 266779010829 hinge residues; other site 266779010830 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266779010831 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266779010832 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779010833 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 266779010834 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266779010835 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 266779010836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266779010837 NAD(P) binding site [chemical binding]; other site 266779010838 active site 266779010839 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266779010840 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like3; cd05668 266779010841 metal binding site [ion binding]; metal-binding site 266779010842 putative dimer interface [polypeptide binding]; other site 266779010843 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 266779010844 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 266779010845 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266779010846 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266779010847 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266779010848 DNA binding residues [nucleotide binding] 266779010849 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 266779010850 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 266779010851 GDP-binding site [chemical binding]; other site 266779010852 ACT binding site; other site 266779010853 IMP binding site; other site 266779010854 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266779010855 EamA-like transporter family; Region: EamA; pfam00892 266779010856 EamA-like transporter family; Region: EamA; pfam00892 266779010857 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 266779010858 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 266779010859 ligand binding site [chemical binding]; other site 266779010860 NAD binding site [chemical binding]; other site 266779010861 dimerization interface [polypeptide binding]; other site 266779010862 catalytic site [active] 266779010863 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 266779010864 putative L-serine binding site [chemical binding]; other site 266779010865 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 266779010866 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266779010867 catalytic residue [active] 266779010868 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 266779010869 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 266779010870 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 266779010871 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 266779010872 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 266779010873 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 266779010874 active site 266779010875 substrate binding site [chemical binding]; other site 266779010876 metal binding site [ion binding]; metal-binding site 266779010877 FtsH Extracellular; Region: FtsH_ext; pfam06480 266779010878 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 266779010879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779010880 Walker A motif; other site 266779010881 ATP binding site [chemical binding]; other site 266779010882 Walker B motif; other site 266779010883 arginine finger; other site 266779010884 Peptidase family M41; Region: Peptidase_M41; pfam01434 266779010885 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 266779010886 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 266779010887 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 266779010888 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266779010889 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266779010890 ligand binding site [chemical binding]; other site 266779010891 translocation protein TolB; Provisional; Region: tolB; PRK05137 266779010892 TolB amino-terminal domain; Region: TolB_N; pfam04052 266779010893 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266779010894 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266779010895 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266779010896 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 266779010897 TolR protein; Region: tolR; TIGR02801 266779010898 TolQ protein; Region: tolQ; TIGR02796 266779010899 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266779010900 active site 266779010901 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 266779010902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779010903 Walker A motif; other site 266779010904 ATP binding site [chemical binding]; other site 266779010905 Walker B motif; other site 266779010906 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 266779010907 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 266779010908 RuvA N terminal domain; Region: RuvA_N; pfam01330 266779010909 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 266779010910 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 266779010911 active site 266779010912 putative DNA-binding cleft [nucleotide binding]; other site 266779010913 dimer interface [polypeptide binding]; other site 266779010914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317 266779010915 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266779010916 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 266779010917 thiamine phosphate binding site [chemical binding]; other site 266779010918 active site 266779010919 pyrophosphate binding site [ion binding]; other site 266779010920 Sel1-like repeats; Region: SEL1; smart00671 266779010921 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266779010922 Sel1-like repeats; Region: SEL1; smart00671 266779010923 Sel1-like repeats; Region: SEL1; smart00671 266779010924 Sel1-like repeats; Region: SEL1; smart00671 266779010925 elongation factor P; Validated; Region: PRK00529 266779010926 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 266779010927 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 266779010928 RNA binding site [nucleotide binding]; other site 266779010929 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 266779010930 RNA binding site [nucleotide binding]; other site 266779010931 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 266779010932 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 266779010933 active site 266779010934 dimerization interface [polypeptide binding]; other site 266779010935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266779010936 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266779010937 NAD(P) binding site [chemical binding]; other site 266779010938 active site 266779010939 hypothetical protein; Validated; Region: PRK09039 266779010940 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266779010941 ligand binding site [chemical binding]; other site 266779010942 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 266779010943 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266779010944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779010945 Walker A/P-loop; other site 266779010946 ATP binding site [chemical binding]; other site 266779010947 Q-loop/lid; other site 266779010948 ABC transporter signature motif; other site 266779010949 Walker B; other site 266779010950 D-loop; other site 266779010951 H-loop/switch region; other site 266779010952 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 266779010953 Rdx family; Region: Rdx; cl01407 266779010954 hypothetical protein; Validated; Region: PRK00110 266779010955 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 266779010956 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 266779010957 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 266779010958 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 266779010959 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266779010960 putative active site [active] 266779010961 metal binding site [ion binding]; metal-binding site 266779010962 homodimer binding site [polypeptide binding]; other site 266779010963 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 266779010964 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 266779010965 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 266779010966 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 266779010967 catalytic triad [active] 266779010968 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 266779010969 putative metal binding site [ion binding]; other site 266779010970 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 266779010971 HemY protein N-terminus; Region: HemY_N; pfam07219 266779010972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 266779010973 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 266779010974 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 266779010975 active site 266779010976 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 266779010977 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 266779010978 active site 266779010979 domain interfaces; other site 266779010980 UGMP family protein; Validated; Region: PRK09604 266779010981 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 266779010982 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 266779010983 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 266779010984 YciI-like protein; Reviewed; Region: PRK12865 266779010985 EVE domain; Region: EVE; cl00728 266779010986 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 266779010987 Isochorismatase family; Region: Isochorismatase; pfam00857 266779010988 catalytic triad [active] 266779010989 metal binding site [ion binding]; metal-binding site 266779010990 conserved cis-peptide bond; other site 266779010991 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 266779010992 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266779010993 catalytic residue [active] 266779010994 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 266779010995 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 266779010996 HIGH motif; other site 266779010997 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 266779010998 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266779010999 active site 266779011000 KMSKS motif; other site 266779011001 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 266779011002 tRNA binding surface [nucleotide binding]; other site 266779011003 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 266779011004 Lipopolysaccharide-assembly; Region: LptE; cl01125 266779011005 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266779011006 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 266779011007 putative acyl-acceptor binding pocket; other site 266779011008 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 266779011009 active site 266779011010 intersubunit interactions; other site 266779011011 catalytic residue [active] 266779011012 primosome assembly protein PriA; Validated; Region: PRK05580 266779011013 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266779011014 ATP binding site [chemical binding]; other site 266779011015 putative Mg++ binding site [ion binding]; other site 266779011016 helicase superfamily c-terminal domain; Region: HELICc; smart00490 266779011017 nucleotide binding region [chemical binding]; other site 266779011018 ATP-binding site [chemical binding]; other site 266779011019 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 266779011020 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 266779011021 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 266779011022 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 266779011023 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 266779011024 beta subunit interaction interface [polypeptide binding]; other site 266779011025 Walker A motif; other site 266779011026 ATP binding site [chemical binding]; other site 266779011027 Walker B motif; other site 266779011028 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266779011029 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 266779011030 core domain interface [polypeptide binding]; other site 266779011031 delta subunit interface [polypeptide binding]; other site 266779011032 epsilon subunit interface [polypeptide binding]; other site 266779011033 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 266779011034 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 266779011035 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 266779011036 alpha subunit interaction interface [polypeptide binding]; other site 266779011037 Walker A motif; other site 266779011038 ATP binding site [chemical binding]; other site 266779011039 Walker B motif; other site 266779011040 inhibitor binding site; inhibition site 266779011041 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266779011042 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 266779011043 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 266779011044 gamma subunit interface [polypeptide binding]; other site 266779011045 epsilon subunit interface [polypeptide binding]; other site 266779011046 LBP interface [polypeptide binding]; other site 266779011047 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 266779011048 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 266779011049 E-class dimer interface [polypeptide binding]; other site 266779011050 P-class dimer interface [polypeptide binding]; other site 266779011051 active site 266779011052 Cu2+ binding site [ion binding]; other site 266779011053 Zn2+ binding site [ion binding]; other site 266779011054 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266779011055 MarR family; Region: MarR_2; pfam12802 266779011056 MarR family; Region: MarR_2; cl17246 266779011057 putative transporter; Provisional; Region: PRK11043 266779011058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779011059 putative substrate translocation pore; other site 266779011060 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 266779011061 active site clefts [active] 266779011062 zinc binding site [ion binding]; other site 266779011063 dimer interface [polypeptide binding]; other site 266779011064 pyridoxamine kinase; Validated; Region: PRK05756 266779011065 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 266779011066 pyridoxal binding site [chemical binding]; other site 266779011067 dimer interface [polypeptide binding]; other site 266779011068 ATP binding site [chemical binding]; other site 266779011069 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 266779011070 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 266779011071 Repair protein; Region: Repair_PSII; pfam04536 266779011072 Predicted membrane protein [Function unknown]; Region: COG3762 266779011073 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266779011074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266779011075 Coenzyme A binding pocket [chemical binding]; other site 266779011076 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 266779011077 dimer interface [polypeptide binding]; other site 266779011078 substrate binding site [chemical binding]; other site 266779011079 metal binding sites [ion binding]; metal-binding site 266779011080 hypothetical protein; Validated; Region: PRK01310 266779011081 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 266779011082 putative catalytic site [active] 266779011083 putative phosphate binding site [ion binding]; other site 266779011084 active site 266779011085 metal binding site A [ion binding]; metal-binding site 266779011086 DNA binding site [nucleotide binding] 266779011087 putative AP binding site [nucleotide binding]; other site 266779011088 putative metal binding site B [ion binding]; other site 266779011089 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 266779011090 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 266779011091 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 266779011092 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 266779011093 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 266779011094 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 266779011095 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 266779011096 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 266779011097 Nitrogen regulatory protein P-II; Region: P-II; smart00938 266779011098 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 266779011099 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 266779011100 active site 266779011101 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 266779011102 catalytic triad [active] 266779011103 dimer interface [polypeptide binding]; other site 266779011104 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 266779011105 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266779011106 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 266779011107 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 266779011108 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 266779011109 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 266779011110 NAD binding site [chemical binding]; other site 266779011111 Phe binding site; other site 266779011112 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 266779011113 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 266779011114 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 266779011115 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 266779011116 L-aspartate oxidase; Provisional; Region: PRK06175 266779011117 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266779011118 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 266779011119 putative SdhC subunit interface [polypeptide binding]; other site 266779011120 putative proximal heme binding site [chemical binding]; other site 266779011121 putative Iron-sulfur protein interface [polypeptide binding]; other site 266779011122 putative proximal quinone binding site; other site 266779011123 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 266779011124 Iron-sulfur protein interface; other site 266779011125 proximal quinone binding site [chemical binding]; other site 266779011126 SdhD (CybS) interface [polypeptide binding]; other site 266779011127 proximal heme binding site [chemical binding]; other site 266779011128 DoxX; Region: DoxX; cl17842 266779011129 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266779011130 Coenzyme A binding pocket [chemical binding]; other site 266779011131 Predicted periplasmic protein [Function unknown]; Region: COG3904 266779011132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 266779011133 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 266779011134 Protein of unknown function (DUF1036); Region: DUF1036; pfam06282 266779011135 pyruvate kinase; Provisional; Region: PRK06247 266779011136 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 266779011137 domain interfaces; other site 266779011138 active site 266779011139 TPR repeat; Region: TPR_11; pfam13414 266779011140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266779011141 TPR motif; other site 266779011142 binding surface 266779011143 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266779011144 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 266779011145 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 266779011146 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 266779011147 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 266779011148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266779011149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779011150 dimer interface [polypeptide binding]; other site 266779011151 conserved gate region; other site 266779011152 putative PBP binding loops; other site 266779011153 ABC-ATPase subunit interface; other site 266779011154 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 266779011155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779011156 Walker A/P-loop; other site 266779011157 ATP binding site [chemical binding]; other site 266779011158 Q-loop/lid; other site 266779011159 ABC transporter signature motif; other site 266779011160 Walker B; other site 266779011161 D-loop; other site 266779011162 H-loop/switch region; other site 266779011163 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 266779011164 Peptidase family M48; Region: Peptidase_M48; pfam01435 266779011165 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 266779011166 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 266779011167 putative active site [active] 266779011168 putative PHP Thumb interface [polypeptide binding]; other site 266779011169 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 266779011170 generic binding surface I; other site 266779011171 generic binding surface II; other site 266779011172 DNA Polymerase Y-family; Region: PolY_like; cd03468 266779011173 active site 266779011174 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 266779011175 DNA binding site [nucleotide binding] 266779011176 Uncharacterized conserved protein [Function unknown]; Region: COG4544 266779011177 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 266779011178 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 266779011179 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266779011180 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 266779011181 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 266779011182 substrate binding site [chemical binding]; other site 266779011183 Uncharacterized conserved protein [Function unknown]; Region: COG2835 266779011184 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 266779011185 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 266779011186 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266779011187 catalytic residues [active] 266779011188 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 266779011189 Cupin domain; Region: Cupin_2; pfam07883 266779011190 Cupin domain; Region: Cupin_2; cl17218 266779011191 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266779011192 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266779011193 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266779011194 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266779011195 active site 266779011196 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266779011197 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266779011198 active site 266779011199 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266779011200 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266779011201 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266779011202 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266779011203 active site 266779011204 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266779011205 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779011206 DNA-binding site [nucleotide binding]; DNA binding site 266779011207 FCD domain; Region: FCD; pfam07729 266779011208 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266779011209 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266779011210 hypothetical protein; Provisional; Region: PRK06126 266779011211 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266779011212 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266779011213 enoyl-CoA hydratase; Provisional; Region: PRK09245 266779011214 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266779011215 substrate binding site [chemical binding]; other site 266779011216 oxyanion hole (OAH) forming residues; other site 266779011217 trimer interface [polypeptide binding]; other site 266779011218 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 266779011219 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266779011220 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266779011221 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 266779011222 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266779011223 NAD(P) binding site [chemical binding]; other site 266779011224 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266779011225 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266779011226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 266779011227 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266779011228 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266779011229 active site 266779011230 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266779011231 active site 2 [active] 266779011232 active site 1 [active] 266779011233 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 266779011234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779011235 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266779011236 putative substrate translocation pore; other site 266779011237 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266779011238 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266779011239 Bacterial transcriptional regulator; Region: IclR; pfam01614 266779011240 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 266779011241 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266779011242 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 266779011243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266779011244 hypothetical protein; Provisional; Region: PRK09739 266779011245 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266779011246 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779011247 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779011248 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266779011249 putative effector binding pocket; other site 266779011250 putative dimerization interface [polypeptide binding]; other site 266779011251 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266779011252 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266779011253 Bacterial transcriptional regulator; Region: IclR; pfam01614 266779011254 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 266779011255 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266779011256 PYR/PP interface [polypeptide binding]; other site 266779011257 dimer interface [polypeptide binding]; other site 266779011258 TPP binding site [chemical binding]; other site 266779011259 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266779011260 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 266779011261 dimer interface [polypeptide binding]; other site 266779011262 TPP-binding site [chemical binding]; other site 266779011263 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266779011264 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 266779011265 NAD(P) binding site [chemical binding]; other site 266779011266 catalytic residues [active] 266779011267 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266779011268 DNA-binding site [nucleotide binding]; DNA binding site 266779011269 RNA-binding motif; other site 266779011270 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266779011271 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266779011272 Bacterial transcriptional regulator; Region: IclR; pfam01614 266779011273 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 266779011274 homodimer interface [polypeptide binding]; other site 266779011275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779011276 catalytic residue [active] 266779011277 serine racemase; Region: PLN02970 266779011278 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266779011279 tetramer interface [polypeptide binding]; other site 266779011280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779011281 catalytic residue [active] 266779011282 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 266779011283 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 266779011284 dimer interface [polypeptide binding]; other site 266779011285 active site 266779011286 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266779011287 substrate binding site [chemical binding]; other site 266779011288 catalytic residue [active] 266779011289 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 266779011290 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266779011291 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 266779011292 dimerization interface [polypeptide binding]; other site 266779011293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266779011294 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266779011295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 266779011296 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 266779011297 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 266779011298 putative NADH binding site [chemical binding]; other site 266779011299 putative active site [active] 266779011300 nudix motif; other site 266779011301 putative metal binding site [ion binding]; other site 266779011302 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 266779011303 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 266779011304 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779011305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779011306 LysR substrate binding domain; Region: LysR_substrate; pfam03466 266779011307 dimerization interface [polypeptide binding]; other site 266779011308 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 266779011309 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 266779011310 tetrameric interface [polypeptide binding]; other site 266779011311 NAD binding site [chemical binding]; other site 266779011312 catalytic residues [active] 266779011313 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266779011314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779011315 DNA-binding site [nucleotide binding]; DNA binding site 266779011316 FCD domain; Region: FCD; pfam07729 266779011317 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266779011318 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266779011319 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266779011320 TM-ABC transporter signature motif; other site 266779011321 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 266779011322 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266779011323 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266779011324 TM-ABC transporter signature motif; other site 266779011325 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266779011326 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266779011327 Walker A/P-loop; other site 266779011328 ATP binding site [chemical binding]; other site 266779011329 Q-loop/lid; other site 266779011330 ABC transporter signature motif; other site 266779011331 Walker B; other site 266779011332 D-loop; other site 266779011333 H-loop/switch region; other site 266779011334 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266779011335 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266779011336 Walker A/P-loop; other site 266779011337 ATP binding site [chemical binding]; other site 266779011338 Q-loop/lid; other site 266779011339 ABC transporter signature motif; other site 266779011340 Walker B; other site 266779011341 D-loop; other site 266779011342 H-loop/switch region; other site 266779011343 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266779011344 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 266779011345 dimerization interface [polypeptide binding]; other site 266779011346 ligand binding site [chemical binding]; other site 266779011347 pyruvate carboxylase; Reviewed; Region: PRK12999 266779011348 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266779011349 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 266779011350 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266779011351 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 266779011352 active site 266779011353 catalytic residues [active] 266779011354 metal binding site [ion binding]; metal-binding site 266779011355 homodimer binding site [polypeptide binding]; other site 266779011356 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266779011357 carboxyltransferase (CT) interaction site; other site 266779011358 biotinylation site [posttranslational modification]; other site 266779011359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779011360 putative substrate translocation pore; other site 266779011361 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266779011362 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 266779011363 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266779011364 Protein export membrane protein; Region: SecD_SecF; cl14618 266779011365 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266779011366 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266779011367 HlyD family secretion protein; Region: HlyD_3; pfam13437 266779011368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266779011369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266779011370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266779011371 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 266779011372 NAD(P) binding site [chemical binding]; other site 266779011373 active site 266779011374 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 266779011375 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 266779011376 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 266779011377 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 266779011378 chorismate mutase; Provisional; Region: PRK09239 266779011379 signal recognition particle protein; Provisional; Region: PRK10867 266779011380 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 266779011381 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 266779011382 P loop; other site 266779011383 GTP binding site [chemical binding]; other site 266779011384 Signal peptide binding domain; Region: SRP_SPB; pfam02978 266779011385 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 266779011386 Bacterial SH3 domain; Region: SH3_3; pfam08239 266779011387 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 266779011388 Transglycosylase SLT domain; Region: SLT_2; pfam13406 266779011389 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266779011390 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266779011391 argininosuccinate synthase; Provisional; Region: PRK13820 266779011392 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 266779011393 ANP binding site [chemical binding]; other site 266779011394 Substrate Binding Site II [chemical binding]; other site 266779011395 Substrate Binding Site I [chemical binding]; other site 266779011396 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 266779011397 Uncharacterized conserved protein [Function unknown]; Region: COG3339 266779011398 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 266779011399 aromatic arch; other site 266779011400 DCoH dimer interaction site [polypeptide binding]; other site 266779011401 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 266779011402 DCoH tetramer interaction site [polypeptide binding]; other site 266779011403 substrate binding site [chemical binding]; other site 266779011404 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266779011405 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 266779011406 active site 266779011407 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 266779011408 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 266779011409 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 266779011410 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 266779011411 active site 266779011412 catalytic triad [active] 266779011413 oxyanion hole [active] 266779011414 switch loop; other site 266779011415 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 266779011416 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266779011417 Walker A/P-loop; other site 266779011418 ATP binding site [chemical binding]; other site 266779011419 Q-loop/lid; other site 266779011420 ABC transporter signature motif; other site 266779011421 Walker B; other site 266779011422 D-loop; other site 266779011423 H-loop/switch region; other site 266779011424 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 266779011425 FtsX-like permease family; Region: FtsX; pfam02687 266779011426 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 266779011427 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 266779011428 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 266779011429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266779011430 Coenzyme A binding pocket [chemical binding]; other site 266779011431 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 266779011432 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 266779011433 aconitate hydratase; Validated; Region: PRK09277 266779011434 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 266779011435 substrate binding site [chemical binding]; other site 266779011436 ligand binding site [chemical binding]; other site 266779011437 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 266779011438 substrate binding site [chemical binding]; other site 266779011439 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 266779011440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779011441 Walker A/P-loop; other site 266779011442 ATP binding site [chemical binding]; other site 266779011443 Q-loop/lid; other site 266779011444 ABC transporter signature motif; other site 266779011445 Walker B; other site 266779011446 D-loop; other site 266779011447 H-loop/switch region; other site 266779011448 heme exporter protein CcmB; Region: ccmB; TIGR01190 266779011449 heme exporter protein CcmC; Region: ccmC; TIGR01191 266779011450 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 266779011451 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 266779011452 catalytic residues [active] 266779011453 central insert; other site 266779011454 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266779011455 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 266779011456 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 266779011457 G1 box; other site 266779011458 putative GEF interaction site [polypeptide binding]; other site 266779011459 GTP/Mg2+ binding site [chemical binding]; other site 266779011460 Switch I region; other site 266779011461 G2 box; other site 266779011462 G3 box; other site 266779011463 Switch II region; other site 266779011464 G4 box; other site 266779011465 G5 box; other site 266779011466 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 266779011467 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 266779011468 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266779011469 hypothetical protein; Provisional; Region: PRK13694 266779011470 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 266779011471 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 266779011472 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 266779011473 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 266779011474 active site 266779011475 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 266779011476 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 266779011477 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 266779011478 Autotransporter beta-domain; Region: Autotransporter; smart00869 266779011479 H+ Antiporter protein; Region: 2A0121; TIGR00900 266779011480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779011481 putative substrate translocation pore; other site 266779011482 YGGT family; Region: YGGT; pfam02325 266779011483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 266779011484 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 266779011485 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 266779011486 putative acyltransferase; Provisional; Region: PRK05790 266779011487 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266779011488 dimer interface [polypeptide binding]; other site 266779011489 active site 266779011490 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 266779011491 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266779011492 NAD(P) binding site [chemical binding]; other site 266779011493 homotetramer interface [polypeptide binding]; other site 266779011494 homodimer interface [polypeptide binding]; other site 266779011495 active site 266779011496 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 266779011497 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266779011498 nucleotide binding region [chemical binding]; other site 266779011499 ATP-binding site [chemical binding]; other site 266779011500 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266779011501 RNA binding surface [nucleotide binding]; other site 266779011502 Ferredoxin [Energy production and conversion]; Region: COG1146 266779011503 4Fe-4S binding domain; Region: Fer4; pfam00037 266779011504 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 266779011505 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 266779011506 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 266779011507 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266779011508 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266779011509 DNA binding residues [nucleotide binding] 266779011510 tartrate dehydrogenase; Region: TTC; TIGR02089 266779011511 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 266779011512 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 266779011513 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266779011514 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 266779011515 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 266779011516 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266779011517 non-specific DNA binding site [nucleotide binding]; other site 266779011518 salt bridge; other site 266779011519 sequence-specific DNA binding site [nucleotide binding]; other site 266779011520 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266779011521 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 266779011522 Sulfate transporter family; Region: Sulfate_transp; pfam00916 266779011523 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266779011524 intracellular septation protein A; Reviewed; Region: PRK00259 266779011525 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 266779011526 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 266779011527 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266779011528 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 266779011529 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 266779011530 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266779011531 FeS/SAM binding site; other site 266779011532 TRAM domain; Region: TRAM; pfam01938 266779011533 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 266779011534 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 266779011535 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 266779011536 Protease inhibitor Inh; Region: Inh; pfam02974 266779011537 Predicted ATPase [General function prediction only]; Region: COG1485 266779011538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779011539 Walker A/P-loop; other site 266779011540 ATP binding site [chemical binding]; other site 266779011541 ABC transporter signature motif; other site 266779011542 Walker B; other site 266779011543 D-loop; other site 266779011544 H-loop/switch region; other site 266779011545 malate dehydrogenase; Reviewed; Region: PRK06223 266779011546 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 266779011547 NAD(P) binding site [chemical binding]; other site 266779011548 dimer interface [polypeptide binding]; other site 266779011549 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266779011550 substrate binding site [chemical binding]; other site 266779011551 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 266779011552 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 266779011553 CoA-ligase; Region: Ligase_CoA; pfam00549 266779011554 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 266779011555 CoA binding domain; Region: CoA_binding; smart00881 266779011556 CoA-ligase; Region: Ligase_CoA; pfam00549 266779011557 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 266779011558 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 266779011559 TPP-binding site [chemical binding]; other site 266779011560 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 266779011561 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 266779011562 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266779011563 E3 interaction surface; other site 266779011564 lipoyl attachment site [posttranslational modification]; other site 266779011565 e3 binding domain; Region: E3_binding; pfam02817 266779011566 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 266779011567 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 266779011568 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 266779011569 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266779011570 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266779011571 TraB family; Region: TraB; cl12050 266779011572 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266779011573 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266779011574 active site 266779011575 DNA binding site [nucleotide binding] 266779011576 Int/Topo IB signature motif; other site 266779011577 ABC transporter ATPase component; Reviewed; Region: PRK11147 266779011578 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266779011579 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266779011580 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 266779011581 Thiamine pyrophosphokinase; Region: TPK; cd07995 266779011582 active site 266779011583 dimerization interface [polypeptide binding]; other site 266779011584 thiamine binding site [chemical binding]; other site 266779011585 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 266779011586 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 266779011587 NAD(P) binding site [chemical binding]; other site 266779011588 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 266779011589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779011590 putative substrate translocation pore; other site 266779011591 Uncharacterized small protein [Function unknown]; Region: COG5570 266779011592 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 266779011593 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 266779011594 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 266779011595 ATP-grasp domain; Region: ATP-grasp; pfam02222 266779011596 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 266779011597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 266779011598 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 266779011599 Catalytic site; other site 266779011600 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 266779011601 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 266779011602 heat shock protein HtpX; Provisional; Region: PRK01345 266779011603 putative RNA binding site [nucleotide binding]; other site 266779011604 NusB family; Region: NusB; pfam01029 266779011605 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 266779011606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779011607 S-adenosylmethionine binding site [chemical binding]; other site 266779011608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360 266779011609 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 266779011610 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 266779011611 purine monophosphate binding site [chemical binding]; other site 266779011612 dimer interface [polypeptide binding]; other site 266779011613 putative catalytic residues [active] 266779011614 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 266779011615 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 266779011616 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 266779011617 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 266779011618 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 266779011619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 266779011620 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266779011621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779011622 active site 266779011623 phosphorylation site [posttranslational modification] 266779011624 intermolecular recognition site; other site 266779011625 dimerization interface [polypeptide binding]; other site 266779011626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266779011627 DNA binding site [nucleotide binding] 266779011628 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266779011629 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266779011630 ligand binding site [chemical binding]; other site 266779011631 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 266779011632 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 266779011633 Transglycosylase; Region: Transgly; pfam00912 266779011634 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 266779011635 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 266779011636 substrate binding pocket [chemical binding]; other site 266779011637 aspartate-rich region 1; other site 266779011638 Usg-like family; Region: Usg; pfam06233 266779011639 acetyl-CoA synthetase; Provisional; Region: PRK00174 266779011640 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 266779011641 active site 266779011642 CoA binding site [chemical binding]; other site 266779011643 acyl-activating enzyme (AAE) consensus motif; other site 266779011644 AMP binding site [chemical binding]; other site 266779011645 acetate binding site [chemical binding]; other site 266779011646 Predicted transcriptional regulator [Transcription]; Region: COG2378 266779011647 HTH domain; Region: HTH_11; pfam08279 266779011648 WYL domain; Region: WYL; pfam13280 266779011649 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 266779011650 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266779011651 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 266779011652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266779011653 NAD(P) binding site [chemical binding]; other site 266779011654 active site 266779011655 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 266779011656 active site 266779011657 intersubunit interface [polypeptide binding]; other site 266779011658 catalytic residue [active] 266779011659 Phosphoglycerate kinase; Region: PGK; pfam00162 266779011660 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 266779011661 substrate binding site [chemical binding]; other site 266779011662 hinge regions; other site 266779011663 ADP binding site [chemical binding]; other site 266779011664 catalytic site [active] 266779011665 potassium/proton antiporter; Reviewed; Region: PRK05326 266779011666 Transporter associated domain; Region: CorC_HlyC; smart01091 266779011667 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 266779011668 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 266779011669 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 266779011670 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 266779011671 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 266779011672 TPP-binding site [chemical binding]; other site 266779011673 dimer interface [polypeptide binding]; other site 266779011674 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266779011675 PYR/PP interface [polypeptide binding]; other site 266779011676 dimer interface [polypeptide binding]; other site 266779011677 TPP binding site [chemical binding]; other site 266779011678 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266779011679 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 266779011680 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 266779011681 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 266779011682 RimM N-terminal domain; Region: RimM; pfam01782 266779011683 PRC-barrel domain; Region: PRC; pfam05239 266779011684 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 266779011685 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 266779011686 MgtC family; Region: MgtC; pfam02308 266779011687 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 266779011688 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 266779011689 substrate binding site [chemical binding]; other site 266779011690 ligand binding site [chemical binding]; other site 266779011691 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 266779011692 putative active site [active] 266779011693 Ap4A binding site [chemical binding]; other site 266779011694 nudix motif; other site 266779011695 putative metal binding site [ion binding]; other site 266779011696 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 266779011697 NodB motif; other site 266779011698 putative active site [active] 266779011699 putative catalytic site [active] 266779011700 Zn binding site [ion binding]; other site 266779011701 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 266779011702 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 266779011703 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 266779011704 protein binding site [polypeptide binding]; other site 266779011705 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 266779011706 Catalytic dyad [active] 266779011707 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 266779011708 Peptidase family M23; Region: Peptidase_M23; pfam01551 266779011709 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 266779011710 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 266779011711 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 266779011712 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 266779011713 active site 266779011714 (T/H)XGH motif; other site 266779011715 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 266779011716 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 266779011717 putative catalytic cysteine [active] 266779011718 gamma-glutamyl kinase; Provisional; Region: PRK05429 266779011719 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 266779011720 nucleotide binding site [chemical binding]; other site 266779011721 homotetrameric interface [polypeptide binding]; other site 266779011722 putative phosphate binding site [ion binding]; other site 266779011723 putative allosteric binding site; other site 266779011724 PUA domain; Region: PUA; pfam01472 266779011725 GTPase CgtA; Reviewed; Region: obgE; PRK12299 266779011726 GTP1/OBG; Region: GTP1_OBG; pfam01018 266779011727 Obg GTPase; Region: Obg; cd01898 266779011728 G1 box; other site 266779011729 GTP/Mg2+ binding site [chemical binding]; other site 266779011730 Switch I region; other site 266779011731 G2 box; other site 266779011732 G3 box; other site 266779011733 Switch II region; other site 266779011734 G4 box; other site 266779011735 G5 box; other site 266779011736 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266779011737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266779011738 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 266779011739 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 266779011740 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 266779011741 Uncharacterized conserved protein [Function unknown]; Region: COG3743 266779011742 Protein of unknown function DUF72; Region: DUF72; pfam01904 266779011743 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266779011744 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 266779011745 FAD binding pocket [chemical binding]; other site 266779011746 FAD binding motif [chemical binding]; other site 266779011747 phosphate binding motif [ion binding]; other site 266779011748 beta-alpha-beta structure motif; other site 266779011749 NAD binding pocket [chemical binding]; other site 266779011750 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 266779011751 6-phosphofructokinase; Provisional; Region: PRK14072 266779011752 active site 266779011753 ADP/pyrophosphate binding site [chemical binding]; other site 266779011754 dimerization interface [polypeptide binding]; other site 266779011755 allosteric effector site; other site 266779011756 fructose-1,6-bisphosphate binding site; other site 266779011757 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 266779011758 ParB-like nuclease domain; Region: ParB; smart00470 266779011759 KorB domain; Region: KorB; pfam08535 266779011760 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266779011761 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266779011762 P-loop; other site 266779011763 Magnesium ion binding site [ion binding]; other site 266779011764 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266779011765 Magnesium ion binding site [ion binding]; other site 266779011766 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 266779011767 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 266779011768 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 266779011769 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 266779011770 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 266779011771 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 266779011772 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 266779011773 trmE is a tRNA modification GTPase; Region: trmE; cd04164 266779011774 G1 box; other site 266779011775 GTP/Mg2+ binding site [chemical binding]; other site 266779011776 Switch I region; other site 266779011777 G2 box; other site 266779011778 Switch II region; other site 266779011779 G3 box; other site 266779011780 G4 box; other site 266779011781 G5 box; other site 266779011782 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 266779011783 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 266779011784 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 266779011785 catalytic residues [active] 266779011786 transcription termination factor Rho; Provisional; Region: rho; PRK09376 266779011787 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 266779011788 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 266779011789 RNA binding site [nucleotide binding]; other site 266779011790 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 266779011791 multimer interface [polypeptide binding]; other site 266779011792 Walker A motif; other site 266779011793 ATP binding site [chemical binding]; other site 266779011794 Walker B motif; other site 266779011795 Predicted membrane protein [Function unknown]; Region: COG1981 266779011796 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 266779011797 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 266779011798 substrate binding site [chemical binding]; other site 266779011799 active site 266779011800 PEP synthetase regulatory protein; Provisional; Region: PRK05339 266779011801 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 266779011802 active site 266779011803 dimer interface [polypeptide binding]; other site 266779011804 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 266779011805 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 266779011806 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 266779011807 shikimate binding site; other site 266779011808 NAD(P) binding site [chemical binding]; other site 266779011809 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 266779011810 dephospho-CoA kinase; Region: TIGR00152 266779011811 CoA-binding site [chemical binding]; other site 266779011812 ATP-binding [chemical binding]; other site 266779011813 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 266779011814 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 266779011815 active site 266779011816 catalytic site [active] 266779011817 substrate binding site [chemical binding]; other site 266779011818 preprotein translocase subunit SecB; Validated; Region: PRK05751 266779011819 SecA binding site; other site 266779011820 Preprotein binding site; other site 266779011821 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 266779011822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 266779011823 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 266779011824 MltA specific insert domain; Region: MltA; smart00925 266779011825 3D domain; Region: 3D; pfam06725 266779011826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 266779011827 Smr domain; Region: Smr; pfam01713 266779011828 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266779011829 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266779011830 sequence-specific DNA binding site [nucleotide binding]; other site 266779011831 salt bridge; other site 266779011832 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 266779011833 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 266779011834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779011835 Walker A motif; other site 266779011836 ATP binding site [chemical binding]; other site 266779011837 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 266779011838 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 266779011839 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 266779011840 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 266779011841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266779011842 Coenzyme A binding pocket [chemical binding]; other site 266779011843 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 266779011844 active site 266779011845 HslU subunit interaction site [polypeptide binding]; other site 266779011846 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 266779011847 putative active site pocket [active] 266779011848 4-fold oligomerization interface [polypeptide binding]; other site 266779011849 metal binding residues [ion binding]; metal-binding site 266779011850 3-fold/trimer interface [polypeptide binding]; other site 266779011851 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 266779011852 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 266779011853 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 266779011854 putative active site [active] 266779011855 oxyanion strand; other site 266779011856 catalytic triad [active] 266779011857 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 266779011858 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 266779011859 catalytic residues [active] 266779011860 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 266779011861 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 266779011862 substrate binding site [chemical binding]; other site 266779011863 glutamase interaction surface [polypeptide binding]; other site 266779011864 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 266779011865 metal binding site [ion binding]; metal-binding site 266779011866 pantothenate kinase; Provisional; Region: PRK05439 266779011867 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 266779011868 ATP-binding site [chemical binding]; other site 266779011869 CoA-binding site [chemical binding]; other site 266779011870 Mg2+-binding site [ion binding]; other site 266779011871 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 266779011872 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 266779011873 hypothetical protein; Provisional; Region: PRK09256 266779011874 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 266779011875 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 266779011876 active site 266779011877 substrate-binding site [chemical binding]; other site 266779011878 metal-binding site [ion binding] 266779011879 ATP binding site [chemical binding]; other site 266779011880 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 266779011881 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 266779011882 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 266779011883 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 266779011884 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 266779011885 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266779011886 active site 266779011887 Predicted integral membrane protein [Function unknown]; Region: COG5528 266779011888 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 266779011889 NADH(P)-binding; Region: NAD_binding_10; pfam13460 266779011890 putative NAD(P) binding site [chemical binding]; other site 266779011891 active site 266779011892 DoxX-like family; Region: DoxX_3; pfam13781 266779011893 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266779011894 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266779011895 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 266779011896 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 266779011897 [2Fe-2S] cluster binding site [ion binding]; other site 266779011898 Predicted membrane protein [Function unknown]; Region: COG2323 266779011899 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 266779011900 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266779011901 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266779011902 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266779011903 Cytochrome P450; Region: p450; cl12078 266779011904 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 266779011905 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 266779011906 dinuclear metal binding motif [ion binding]; other site 266779011907 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 266779011908 OTU-like cysteine protease; Region: OTU; pfam02338 266779011909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266779011910 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266779011911 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266779011912 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 266779011913 classical (c) SDRs; Region: SDR_c; cd05233 266779011914 NAD(P) binding site [chemical binding]; other site 266779011915 active site 266779011916 SEC-C motif; Region: SEC-C; pfam02810 266779011917 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 266779011918 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 266779011919 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 266779011920 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 266779011921 Trp docking motif [polypeptide binding]; other site 266779011922 putative active site [active] 266779011923 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 266779011924 dimerization interface [polypeptide binding]; other site 266779011925 metal binding site [ion binding]; metal-binding site 266779011926 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 266779011927 Erythromycin esterase; Region: Erythro_esteras; pfam05139 266779011928 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266779011929 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266779011930 active site 266779011931 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 266779011932 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 266779011933 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 266779011934 Autotransporter beta-domain; Region: Autotransporter; smart00869 266779011935 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 266779011936 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 266779011937 Subunit I/III interface [polypeptide binding]; other site 266779011938 Subunit III/IV interface [polypeptide binding]; other site 266779011939 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266779011940 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 266779011941 D-pathway; other site 266779011942 Putative ubiquinol binding site [chemical binding]; other site 266779011943 Low-spin heme (heme b) binding site [chemical binding]; other site 266779011944 Putative water exit pathway; other site 266779011945 Binuclear center (heme o3/CuB) [ion binding]; other site 266779011946 K-pathway; other site 266779011947 Putative proton exit pathway; other site 266779011948 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 266779011949 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266779011950 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 266779011951 Cupin domain; Region: Cupin_2; pfam07883 266779011952 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266779011953 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266779011954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266779011955 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266779011956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266779011957 dimer interface [polypeptide binding]; other site 266779011958 conserved gate region; other site 266779011959 putative PBP binding loops; other site 266779011960 ABC-ATPase subunit interface; other site 266779011961 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266779011962 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266779011963 Walker A/P-loop; other site 266779011964 ATP binding site [chemical binding]; other site 266779011965 Q-loop/lid; other site 266779011966 ABC transporter signature motif; other site 266779011967 Walker B; other site 266779011968 D-loop; other site 266779011969 H-loop/switch region; other site 266779011970 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266779011971 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266779011972 substrate binding pocket [chemical binding]; other site 266779011973 membrane-bound complex binding site; other site 266779011974 AMP-binding domain protein; Validated; Region: PRK07529 266779011975 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266779011976 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 266779011977 acyl-activating enzyme (AAE) consensus motif; other site 266779011978 putative AMP binding site [chemical binding]; other site 266779011979 putative active site [active] 266779011980 putative CoA binding site [chemical binding]; other site 266779011981 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779011982 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779011983 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 266779011984 substrate binding pocket [chemical binding]; other site 266779011985 dimerization interface [polypeptide binding]; other site 266779011986 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266779011987 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266779011988 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266779011989 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 266779011990 NAD binding site [chemical binding]; other site 266779011991 homotetramer interface [polypeptide binding]; other site 266779011992 homodimer interface [polypeptide binding]; other site 266779011993 active site 266779011994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779011995 metabolite-proton symporter; Region: 2A0106; TIGR00883 266779011996 putative substrate translocation pore; other site 266779011997 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 266779011998 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266779011999 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266779012000 active site pocket [active] 266779012001 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266779012002 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779012003 DNA-binding site [nucleotide binding]; DNA binding site 266779012004 FCD domain; Region: FCD; pfam07729 266779012005 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 266779012006 homotrimer interaction site [polypeptide binding]; other site 266779012007 putative active site [active] 266779012008 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 266779012009 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266779012010 dimer interface [polypeptide binding]; other site 266779012011 active site 266779012012 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 266779012013 nucleotide binding site [chemical binding]; other site 266779012014 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 266779012015 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266779012016 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266779012017 Walker A/P-loop; other site 266779012018 ATP binding site [chemical binding]; other site 266779012019 Q-loop/lid; other site 266779012020 ABC transporter signature motif; other site 266779012021 Walker B; other site 266779012022 D-loop; other site 266779012023 H-loop/switch region; other site 266779012024 TOBE domain; Region: TOBE_2; pfam08402 266779012025 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266779012026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779012027 dimer interface [polypeptide binding]; other site 266779012028 conserved gate region; other site 266779012029 putative PBP binding loops; other site 266779012030 ABC-ATPase subunit interface; other site 266779012031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779012032 dimer interface [polypeptide binding]; other site 266779012033 conserved gate region; other site 266779012034 putative PBP binding loops; other site 266779012035 ABC-ATPase subunit interface; other site 266779012036 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266779012037 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266779012038 MarR family; Region: MarR_2; pfam12802 266779012039 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266779012040 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266779012041 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266779012042 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266779012043 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266779012044 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266779012045 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 266779012046 maleylacetoacetate isomerase; Region: maiA; TIGR01262 266779012047 C-terminal domain interface [polypeptide binding]; other site 266779012048 GSH binding site (G-site) [chemical binding]; other site 266779012049 putative dimer interface [polypeptide binding]; other site 266779012050 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 266779012051 dimer interface [polypeptide binding]; other site 266779012052 N-terminal domain interface [polypeptide binding]; other site 266779012053 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 266779012054 MarR family; Region: MarR_2; cl17246 266779012055 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266779012056 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 266779012057 Cupin domain; Region: Cupin_2; pfam07883 266779012058 Cupin domain; Region: Cupin_2; cl17218 266779012059 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 266779012060 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 266779012061 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266779012062 minor groove reading motif; other site 266779012063 helix-hairpin-helix signature motif; other site 266779012064 substrate binding pocket [chemical binding]; other site 266779012065 active site 266779012066 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 266779012067 Integral membrane protein [Function unknown]; Region: COG5488 266779012068 Helix-turn-helix domain; Region: HTH_18; pfam12833 266779012069 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 266779012070 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266779012071 DNA binding site [nucleotide binding] 266779012072 active site 266779012073 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266779012074 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 266779012075 substrate binding site [chemical binding]; other site 266779012076 dimer interface [polypeptide binding]; other site 266779012077 ATP binding site [chemical binding]; other site 266779012078 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266779012079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779012080 active site 266779012081 phosphorylation site [posttranslational modification] 266779012082 intermolecular recognition site; other site 266779012083 dimerization interface [polypeptide binding]; other site 266779012084 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266779012085 DNA binding site [nucleotide binding] 266779012086 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 266779012087 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 266779012088 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266779012089 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779012090 dimer interface [polypeptide binding]; other site 266779012091 phosphorylation site [posttranslational modification] 266779012092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779012093 ATP binding site [chemical binding]; other site 266779012094 Mg2+ binding site [ion binding]; other site 266779012095 G-X-G motif; other site 266779012096 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 266779012097 Hpr binding site; other site 266779012098 active site 266779012099 homohexamer subunit interaction site [polypeptide binding]; other site 266779012100 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 266779012101 active pocket/dimerization site; other site 266779012102 active site 266779012103 phosphorylation site [posttranslational modification] 266779012104 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 266779012105 regulatory protein interface [polypeptide binding]; other site 266779012106 active site 266779012107 regulatory phosphorylation site [posttranslational modification]; other site 266779012108 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 266779012109 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 266779012110 homotetramer interface [polypeptide binding]; other site 266779012111 ligand binding site [chemical binding]; other site 266779012112 catalytic site [active] 266779012113 NAD binding site [chemical binding]; other site 266779012114 PAS fold; Region: PAS_7; pfam12860 266779012115 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266779012116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779012117 dimer interface [polypeptide binding]; other site 266779012118 phosphorylation site [posttranslational modification] 266779012119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779012120 ATP binding site [chemical binding]; other site 266779012121 Mg2+ binding site [ion binding]; other site 266779012122 G-X-G motif; other site 266779012123 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 266779012124 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 266779012125 Phosphotransferase enzyme family; Region: APH; pfam01636 266779012126 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 266779012127 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 266779012128 Substrate binding site; other site 266779012129 metal-binding site 266779012130 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 266779012131 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 266779012132 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 266779012133 Part of AAA domain; Region: AAA_19; pfam13245 266779012134 Family description; Region: UvrD_C_2; pfam13538 266779012135 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 266779012136 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266779012137 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266779012138 catalytic residues [active] 266779012139 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 266779012140 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 266779012141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779012142 Walker A motif; other site 266779012143 ATP binding site [chemical binding]; other site 266779012144 Walker B motif; other site 266779012145 arginine finger; other site 266779012146 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 266779012147 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 266779012148 glutathione synthetase; Provisional; Region: PRK05246 266779012149 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 266779012150 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 266779012151 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266779012152 metal binding site [ion binding]; metal-binding site 266779012153 active site 266779012154 I-site; other site 266779012155 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266779012156 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266779012157 classical (c) SDRs; Region: SDR_c; cd05233 266779012158 NAD(P) binding site [chemical binding]; other site 266779012159 active site 266779012160 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266779012161 Protein of unknown function (DUF1838); Region: DUF1838; pfam08894 266779012162 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266779012163 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 266779012164 NAD(P) binding site [chemical binding]; other site 266779012165 catalytic residues [active] 266779012166 hypothetical protein; Provisional; Region: PRK08266 266779012167 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266779012168 PYR/PP interface [polypeptide binding]; other site 266779012169 dimer interface [polypeptide binding]; other site 266779012170 TPP binding site [chemical binding]; other site 266779012171 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266779012172 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266779012173 TPP-binding site [chemical binding]; other site 266779012174 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266779012175 catalytic core [active] 266779012176 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 266779012177 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 266779012178 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 266779012179 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266779012180 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266779012181 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 266779012182 Walker A/P-loop; other site 266779012183 ATP binding site [chemical binding]; other site 266779012184 Q-loop/lid; other site 266779012185 ABC transporter signature motif; other site 266779012186 Walker B; other site 266779012187 D-loop; other site 266779012188 H-loop/switch region; other site 266779012189 glucokinase; Provisional; Region: glk; PRK00292 266779012190 glucokinase, proteobacterial type; Region: glk; TIGR00749 266779012191 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 266779012192 active site 266779012193 dimer interfaces [polypeptide binding]; other site 266779012194 catalytic residues [active] 266779012195 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 266779012196 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 266779012197 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266779012198 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 266779012199 putative NAD(P) binding site [chemical binding]; other site 266779012200 epoxyqueuosine reductase; Region: TIGR00276 266779012201 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 266779012202 HEAT repeat; Region: HEAT; pfam02985 266779012203 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266779012204 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266779012205 C-terminal domain interface [polypeptide binding]; other site 266779012206 GSH binding site (G-site) [chemical binding]; other site 266779012207 dimer interface [polypeptide binding]; other site 266779012208 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 266779012209 N-terminal domain interface [polypeptide binding]; other site 266779012210 dimer interface [polypeptide binding]; other site 266779012211 substrate binding pocket (H-site) [chemical binding]; other site 266779012212 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 266779012213 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266779012214 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 266779012215 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 266779012216 putative NAD(P) binding site [chemical binding]; other site 266779012217 active site 266779012218 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 266779012219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779012220 Mg2+ binding site [ion binding]; other site 266779012221 G-X-G motif; other site 266779012222 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 266779012223 anchoring element; other site 266779012224 dimer interface [polypeptide binding]; other site 266779012225 ATP binding site [chemical binding]; other site 266779012226 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 266779012227 active site 266779012228 metal binding site [ion binding]; metal-binding site 266779012229 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 266779012230 hypothetical protein; Provisional; Region: PRK00736 266779012231 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266779012232 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266779012233 metal binding site [ion binding]; metal-binding site 266779012234 active site 266779012235 I-site; other site 266779012236 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266779012237 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 266779012238 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 266779012239 RNA binding site [nucleotide binding]; other site 266779012240 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 266779012241 RNA binding site [nucleotide binding]; other site 266779012242 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 266779012243 RNA binding site [nucleotide binding]; other site 266779012244 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 266779012245 RNA binding site [nucleotide binding]; other site 266779012246 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 266779012247 RNA binding site [nucleotide binding]; other site 266779012248 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 266779012249 RNA binding site [nucleotide binding]; other site 266779012250 cytidylate kinase; Provisional; Region: cmk; PRK00023 266779012251 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 266779012252 CMP-binding site; other site 266779012253 The sites determining sugar specificity; other site 266779012254 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 266779012255 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266779012256 putative NAD(P) binding site [chemical binding]; other site 266779012257 putative active site [active] 266779012258 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 266779012259 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 266779012260 hinge; other site 266779012261 active site 266779012262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 266779012263 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 266779012264 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 266779012265 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 266779012266 molybdopterin cofactor binding site [chemical binding]; other site 266779012267 substrate binding site [chemical binding]; other site 266779012268 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 266779012269 molybdopterin cofactor binding site; other site 266779012270 Domain of unknown function (DUF296); Region: DUF296; pfam03479 266779012271 trimer interface [polypeptide binding]; other site 266779012272 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266779012273 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266779012274 Bacterial transcriptional regulator; Region: IclR; pfam01614 266779012275 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 266779012276 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 266779012277 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 266779012278 DctM-like transporters; Region: DctM; pfam06808 266779012279 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 266779012280 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266779012281 classical (c) SDRs; Region: SDR_c; cd05233 266779012282 NAD(P) binding site [chemical binding]; other site 266779012283 active site 266779012284 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 266779012285 TPP-binding site [chemical binding]; other site 266779012286 dimer interface [polypeptide binding]; other site 266779012287 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 266779012288 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266779012289 PYR/PP interface [polypeptide binding]; other site 266779012290 dimer interface [polypeptide binding]; other site 266779012291 TPP binding site [chemical binding]; other site 266779012292 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266779012293 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266779012294 classical (c) SDRs; Region: SDR_c; cd05233 266779012295 NAD(P) binding site [chemical binding]; other site 266779012296 active site 266779012297 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266779012298 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 266779012299 putative active site pocket [active] 266779012300 metal binding site [ion binding]; metal-binding site 266779012301 fumarate hydratase; Reviewed; Region: fumC; PRK00485 266779012302 Class II fumarases; Region: Fumarase_classII; cd01362 266779012303 active site 266779012304 tetramer interface [polypeptide binding]; other site 266779012305 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 266779012306 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 266779012307 tetramer interface [polypeptide binding]; other site 266779012308 active site 266779012309 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 266779012310 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 266779012311 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 266779012312 DctM-like transporters; Region: DctM; pfam06808 266779012313 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266779012314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779012315 DNA-binding site [nucleotide binding]; DNA binding site 266779012316 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 266779012317 aspartate aminotransferase; Provisional; Region: PRK05764 266779012318 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266779012319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779012320 homodimer interface [polypeptide binding]; other site 266779012321 catalytic residue [active] 266779012322 aldehyde dehydrogenase family 7 member; Region: PLN02315 266779012323 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 266779012324 tetrameric interface [polypeptide binding]; other site 266779012325 NAD binding site [chemical binding]; other site 266779012326 catalytic residues [active] 266779012327 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 266779012328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 266779012329 cystathionine beta-lyase, bacterial; Region: cysta_beta_ly_B; TIGR01324 266779012330 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266779012331 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266779012332 catalytic residue [active] 266779012333 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 266779012334 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 266779012335 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 266779012336 active site residue [active] 266779012337 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 266779012338 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 266779012339 putative active site [active] 266779012340 putative FMN binding site [chemical binding]; other site 266779012341 putative substrate binding site [chemical binding]; other site 266779012342 putative catalytic residue [active] 266779012343 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266779012344 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 266779012345 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779012346 Walker A/P-loop; other site 266779012347 ATP binding site [chemical binding]; other site 266779012348 Q-loop/lid; other site 266779012349 ABC transporter signature motif; other site 266779012350 Walker B; other site 266779012351 D-loop; other site 266779012352 H-loop/switch region; other site 266779012353 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779012354 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779012355 Walker A/P-loop; other site 266779012356 ATP binding site [chemical binding]; other site 266779012357 Q-loop/lid; other site 266779012358 ABC transporter signature motif; other site 266779012359 Walker B; other site 266779012360 D-loop; other site 266779012361 H-loop/switch region; other site 266779012362 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266779012363 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266779012364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779012365 dimer interface [polypeptide binding]; other site 266779012366 conserved gate region; other site 266779012367 putative PBP binding loops; other site 266779012368 ABC-ATPase subunit interface; other site 266779012369 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779012370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779012371 dimer interface [polypeptide binding]; other site 266779012372 conserved gate region; other site 266779012373 putative PBP binding loops; other site 266779012374 ABC-ATPase subunit interface; other site 266779012375 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266779012376 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266779012377 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266779012378 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266779012379 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 266779012380 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 266779012381 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 266779012382 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 266779012383 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 266779012384 acyl-activating enzyme (AAE) consensus motif; other site 266779012385 putative AMP binding site [chemical binding]; other site 266779012386 putative active site [active] 266779012387 putative CoA binding site [chemical binding]; other site 266779012388 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266779012389 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266779012390 substrate binding site [chemical binding]; other site 266779012391 oxyanion hole (OAH) forming residues; other site 266779012392 trimer interface [polypeptide binding]; other site 266779012393 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266779012394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779012395 dimer interface [polypeptide binding]; other site 266779012396 conserved gate region; other site 266779012397 putative PBP binding loops; other site 266779012398 ABC-ATPase subunit interface; other site 266779012399 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 266779012400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779012401 dimer interface [polypeptide binding]; other site 266779012402 conserved gate region; other site 266779012403 putative PBP binding loops; other site 266779012404 ABC-ATPase subunit interface; other site 266779012405 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266779012406 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 266779012407 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266779012408 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266779012409 Bacterial transcriptional regulator; Region: IclR; pfam01614 266779012410 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266779012411 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779012412 Walker A/P-loop; other site 266779012413 ATP binding site [chemical binding]; other site 266779012414 Q-loop/lid; other site 266779012415 ABC transporter signature motif; other site 266779012416 Walker B; other site 266779012417 D-loop; other site 266779012418 H-loop/switch region; other site 266779012419 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266779012420 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779012421 Walker A/P-loop; other site 266779012422 ATP binding site [chemical binding]; other site 266779012423 Q-loop/lid; other site 266779012424 ABC transporter signature motif; other site 266779012425 Walker B; other site 266779012426 D-loop; other site 266779012427 H-loop/switch region; other site 266779012428 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266779012429 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266779012430 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 266779012431 CGNR zinc finger; Region: zf-CGNR; pfam11706 266779012432 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 266779012433 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 266779012434 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266779012435 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266779012436 Walker A/P-loop; other site 266779012437 ATP binding site [chemical binding]; other site 266779012438 Q-loop/lid; other site 266779012439 ABC transporter signature motif; other site 266779012440 Walker B; other site 266779012441 D-loop; other site 266779012442 H-loop/switch region; other site 266779012443 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266779012444 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266779012445 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266779012446 TM-ABC transporter signature motif; other site 266779012447 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266779012448 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266779012449 TM-ABC transporter signature motif; other site 266779012450 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 266779012451 active site 266779012452 catalytic motif [active] 266779012453 Zn binding site [ion binding]; other site 266779012454 purine nucleoside phosphorylase; Provisional; Region: PRK08202 266779012455 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 266779012456 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 266779012457 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 266779012458 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 266779012459 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266779012460 active site 266779012461 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 266779012462 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 266779012463 active site 266779012464 purine riboside binding site [chemical binding]; other site 266779012465 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 266779012466 AAA domain; Region: AAA_18; pfam13238 266779012467 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 266779012468 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266779012469 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 266779012470 active site 266779012471 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 266779012472 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266779012473 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 266779012474 putative dimer interface [polypeptide binding]; other site 266779012475 Uncharacterized small protein [Function unknown]; Region: COG5568 266779012476 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 266779012477 active site 266779012478 phosphorylation site [posttranslational modification] 266779012479 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 266779012480 30S subunit binding site; other site 266779012481 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 266779012482 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 266779012483 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 266779012484 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 266779012485 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 266779012486 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 266779012487 Walker A/P-loop; other site 266779012488 ATP binding site [chemical binding]; other site 266779012489 Q-loop/lid; other site 266779012490 ABC transporter signature motif; other site 266779012491 Walker B; other site 266779012492 D-loop; other site 266779012493 H-loop/switch region; other site 266779012494 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 266779012495 OstA-like protein; Region: OstA; pfam03968 266779012496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 266779012497 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 266779012498 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 266779012499 tandem repeat interface [polypeptide binding]; other site 266779012500 oligomer interface [polypeptide binding]; other site 266779012501 active site residues [active] 266779012502 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266779012503 IHF dimer interface [polypeptide binding]; other site 266779012504 IHF - DNA interface [nucleotide binding]; other site 266779012505 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 266779012506 ornithine cyclodeaminase; Validated; Region: PRK06141 266779012507 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 266779012508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779012509 S-adenosylmethionine binding site [chemical binding]; other site 266779012510 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 266779012511 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 266779012512 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 266779012513 lipoprotein signal peptidase; Provisional; Region: PRK14795 266779012514 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 266779012515 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 266779012516 NADP binding site [chemical binding]; other site 266779012517 dimer interface [polypeptide binding]; other site 266779012518 PAS domain; Region: PAS; smart00091 266779012519 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266779012520 putative active site [active] 266779012521 heme pocket [chemical binding]; other site 266779012522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779012523 dimer interface [polypeptide binding]; other site 266779012524 phosphorylation site [posttranslational modification] 266779012525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779012526 ATP binding site [chemical binding]; other site 266779012527 Mg2+ binding site [ion binding]; other site 266779012528 G-X-G motif; other site 266779012529 Response regulator receiver domain; Region: Response_reg; pfam00072 266779012530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779012531 active site 266779012532 phosphorylation site [posttranslational modification] 266779012533 intermolecular recognition site; other site 266779012534 dimerization interface [polypeptide binding]; other site 266779012535 Putative hemolysin [General function prediction only]; Region: COG3176 266779012536 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 266779012537 classical (c) SDRs; Region: SDR_c; cd05233 266779012538 NAD(P) binding site [chemical binding]; other site 266779012539 active site 266779012540 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 266779012541 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266779012542 NAD binding site [chemical binding]; other site 266779012543 catalytic Zn binding site [ion binding]; other site 266779012544 structural Zn binding site [ion binding]; other site 266779012545 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 266779012546 putative hydrophobic ligand binding site [chemical binding]; other site 266779012547 short chain dehydrogenase; Provisional; Region: PRK07109 266779012548 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 266779012549 putative NAD(P) binding site [chemical binding]; other site 266779012550 active site 266779012551 trehalose synthase; Region: treS_nterm; TIGR02456 266779012552 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 266779012553 active site 266779012554 catalytic site [active] 266779012555 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 266779012556 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 266779012557 active site 266779012558 catalytic site [active] 266779012559 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 266779012560 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 266779012561 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 266779012562 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 266779012563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779012564 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266779012565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779012566 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 266779012567 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 266779012568 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 266779012569 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 266779012570 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266779012571 putative ADP-binding pocket [chemical binding]; other site 266779012572 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 266779012573 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 266779012574 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 266779012575 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 266779012576 Walker A/P-loop; other site 266779012577 ATP binding site [chemical binding]; other site 266779012578 Q-loop/lid; other site 266779012579 ABC transporter signature motif; other site 266779012580 Walker B; other site 266779012581 D-loop; other site 266779012582 H-loop/switch region; other site 266779012583 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 266779012584 putative carbohydrate binding site [chemical binding]; other site 266779012585 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266779012586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779012587 S-adenosylmethionine binding site [chemical binding]; other site 266779012588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 266779012589 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266779012590 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266779012591 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266779012592 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266779012593 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 266779012594 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 266779012595 active site 266779012596 homodimer interface [polypeptide binding]; other site 266779012597 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266779012598 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266779012599 active site 266779012600 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266779012601 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266779012602 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266779012603 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266779012604 NAD(P) binding site [chemical binding]; other site 266779012605 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266779012606 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266779012607 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266779012608 putative active site [active] 266779012609 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266779012610 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266779012611 substrate binding site [chemical binding]; other site 266779012612 ATP binding site [chemical binding]; other site 266779012613 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 266779012614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 266779012615 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266779012616 classical (c) SDRs; Region: SDR_c; cd05233 266779012617 NAD(P) binding site [chemical binding]; other site 266779012618 active site 266779012619 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266779012620 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_9; cd06318 266779012621 putative ligand binding site [chemical binding]; other site 266779012622 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266779012623 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266779012624 Walker A/P-loop; other site 266779012625 ATP binding site [chemical binding]; other site 266779012626 Q-loop/lid; other site 266779012627 ABC transporter signature motif; other site 266779012628 Walker B; other site 266779012629 D-loop; other site 266779012630 H-loop/switch region; other site 266779012631 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266779012632 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266779012633 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266779012634 TM-ABC transporter signature motif; other site 266779012635 choline dehydrogenase; Validated; Region: PRK02106 266779012636 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266779012637 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 266779012638 Predicted flavoprotein [General function prediction only]; Region: COG0431 266779012639 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266779012640 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266779012641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266779012642 NAD(P) binding site [chemical binding]; other site 266779012643 active site 266779012644 DctM-like transporters; Region: DctM; pfam06808 266779012645 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 266779012646 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 266779012647 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 266779012648 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266779012649 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 266779012650 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266779012651 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 266779012652 hypothetical protein; Provisional; Region: PRK02399 266779012653 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 266779012654 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266779012655 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779012656 DNA-binding site [nucleotide binding]; DNA binding site 266779012657 FCD domain; Region: FCD; pfam07729 266779012658 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 266779012659 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 266779012660 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 266779012661 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779012662 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266779012663 dimerization interface [polypeptide binding]; other site 266779012664 substrate binding pocket [chemical binding]; other site 266779012665 EPTP domain; Region: EPTP; pfam03736 266779012666 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 266779012667 Zn binding site [ion binding]; other site 266779012668 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 266779012669 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266779012670 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266779012671 active site 266779012672 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266779012673 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779012674 Walker A/P-loop; other site 266779012675 ATP binding site [chemical binding]; other site 266779012676 Q-loop/lid; other site 266779012677 ABC transporter signature motif; other site 266779012678 Walker B; other site 266779012679 D-loop; other site 266779012680 H-loop/switch region; other site 266779012681 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266779012682 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 266779012683 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779012684 Walker A/P-loop; other site 266779012685 ATP binding site [chemical binding]; other site 266779012686 Q-loop/lid; other site 266779012687 ABC transporter signature motif; other site 266779012688 Walker B; other site 266779012689 D-loop; other site 266779012690 H-loop/switch region; other site 266779012691 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266779012692 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779012693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779012694 dimer interface [polypeptide binding]; other site 266779012695 conserved gate region; other site 266779012696 putative PBP binding loops; other site 266779012697 ABC-ATPase subunit interface; other site 266779012698 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266779012699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779012700 dimer interface [polypeptide binding]; other site 266779012701 conserved gate region; other site 266779012702 putative PBP binding loops; other site 266779012703 ABC-ATPase subunit interface; other site 266779012704 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266779012705 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266779012706 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266779012707 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266779012708 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266779012709 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266779012710 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 266779012711 choline dehydrogenase; Validated; Region: PRK02106 266779012712 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266779012713 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 266779012714 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266779012715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779012716 homodimer interface [polypeptide binding]; other site 266779012717 catalytic residue [active] 266779012718 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266779012719 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 266779012720 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266779012721 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779012722 Walker A/P-loop; other site 266779012723 ATP binding site [chemical binding]; other site 266779012724 Q-loop/lid; other site 266779012725 ABC transporter signature motif; other site 266779012726 Walker B; other site 266779012727 D-loop; other site 266779012728 H-loop/switch region; other site 266779012729 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779012730 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 266779012731 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779012732 Walker A/P-loop; other site 266779012733 ATP binding site [chemical binding]; other site 266779012734 Q-loop/lid; other site 266779012735 ABC transporter signature motif; other site 266779012736 Walker B; other site 266779012737 D-loop; other site 266779012738 H-loop/switch region; other site 266779012739 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779012740 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266779012741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779012742 dimer interface [polypeptide binding]; other site 266779012743 conserved gate region; other site 266779012744 ABC-ATPase subunit interface; other site 266779012745 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266779012746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779012747 dimer interface [polypeptide binding]; other site 266779012748 conserved gate region; other site 266779012749 putative PBP binding loops; other site 266779012750 ABC-ATPase subunit interface; other site 266779012751 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779012752 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266779012753 putative effector binding pocket; other site 266779012754 dimerization interface [polypeptide binding]; other site 266779012755 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 266779012756 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 266779012757 molybdopterin cofactor binding site [chemical binding]; other site 266779012758 substrate binding site [chemical binding]; other site 266779012759 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 266779012760 molybdopterin cofactor binding site; other site 266779012761 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266779012762 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779012763 Walker A/P-loop; other site 266779012764 ATP binding site [chemical binding]; other site 266779012765 Q-loop/lid; other site 266779012766 ABC transporter signature motif; other site 266779012767 Walker B; other site 266779012768 D-loop; other site 266779012769 H-loop/switch region; other site 266779012770 TOBE domain; Region: TOBE_2; pfam08402 266779012771 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266779012772 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266779012773 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 266779012774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779012775 dimer interface [polypeptide binding]; other site 266779012776 conserved gate region; other site 266779012777 putative PBP binding loops; other site 266779012778 ABC-ATPase subunit interface; other site 266779012779 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266779012780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779012781 dimer interface [polypeptide binding]; other site 266779012782 conserved gate region; other site 266779012783 putative PBP binding loops; other site 266779012784 ABC-ATPase subunit interface; other site 266779012785 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 266779012786 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 266779012787 active site residue [active] 266779012788 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 266779012789 active site residue [active] 266779012790 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266779012791 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266779012792 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266779012793 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266779012794 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266779012795 substrate binding site [chemical binding]; other site 266779012796 oxyanion hole (OAH) forming residues; other site 266779012797 trimer interface [polypeptide binding]; other site 266779012798 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266779012799 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 266779012800 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266779012801 enoyl-CoA hydratase; Provisional; Region: PRK06495 266779012802 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266779012803 substrate binding site [chemical binding]; other site 266779012804 oxyanion hole (OAH) forming residues; other site 266779012805 trimer interface [polypeptide binding]; other site 266779012806 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266779012807 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 266779012808 putative ligand binding site [chemical binding]; other site 266779012809 NAD binding site [chemical binding]; other site 266779012810 catalytic site [active] 266779012811 choline dehydrogenase; Validated; Region: PRK02106 266779012812 lycopene cyclase; Region: lycopene_cycl; TIGR01789 266779012813 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266779012814 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 266779012815 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266779012816 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266779012817 active site 266779012818 dihydroxy-acid dehydratase; Validated; Region: PRK06131 266779012819 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266779012820 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266779012821 inhibitor site; inhibition site 266779012822 active site 266779012823 dimer interface [polypeptide binding]; other site 266779012824 catalytic residue [active] 266779012825 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266779012826 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779012827 DNA-binding site [nucleotide binding]; DNA binding site 266779012828 FCD domain; Region: FCD; pfam07729 266779012829 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 266779012830 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 266779012831 DAK2 domain; Region: Dak2; pfam02734 266779012832 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266779012833 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266779012834 active site 266779012835 catalytic tetrad [active] 266779012836 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 266779012837 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 266779012838 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266779012839 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266779012840 tetramerization interface [polypeptide binding]; other site 266779012841 NAD(P) binding site [chemical binding]; other site 266779012842 catalytic residues [active] 266779012843 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266779012844 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266779012845 conserved cys residue [active] 266779012846 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266779012847 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266779012848 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266779012849 Walker A/P-loop; other site 266779012850 ATP binding site [chemical binding]; other site 266779012851 Q-loop/lid; other site 266779012852 ABC transporter signature motif; other site 266779012853 Walker B; other site 266779012854 D-loop; other site 266779012855 H-loop/switch region; other site 266779012856 TOBE domain; Region: TOBE; pfam03459 266779012857 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 266779012858 classical (c) SDRs; Region: SDR_c; cd05233 266779012859 NAD(P) binding site [chemical binding]; other site 266779012860 active site 266779012861 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266779012862 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266779012863 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266779012864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779012865 dimer interface [polypeptide binding]; other site 266779012866 conserved gate region; other site 266779012867 putative PBP binding loops; other site 266779012868 ABC-ATPase subunit interface; other site 266779012869 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266779012870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779012871 dimer interface [polypeptide binding]; other site 266779012872 conserved gate region; other site 266779012873 putative PBP binding loops; other site 266779012874 ABC-ATPase subunit interface; other site 266779012875 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266779012876 classical (c) SDRs; Region: SDR_c; cd05233 266779012877 NAD(P) binding site [chemical binding]; other site 266779012878 active site 266779012879 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 266779012880 MarR family; Region: MarR_2; pfam12802 266779012881 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 266779012882 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266779012883 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266779012884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779012885 dimer interface [polypeptide binding]; other site 266779012886 conserved gate region; other site 266779012887 putative PBP binding loops; other site 266779012888 ABC-ATPase subunit interface; other site 266779012889 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266779012890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266779012891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779012892 dimer interface [polypeptide binding]; other site 266779012893 conserved gate region; other site 266779012894 putative PBP binding loops; other site 266779012895 ABC-ATPase subunit interface; other site 266779012896 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266779012897 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266779012898 Walker A/P-loop; other site 266779012899 ATP binding site [chemical binding]; other site 266779012900 Q-loop/lid; other site 266779012901 ABC transporter signature motif; other site 266779012902 Walker B; other site 266779012903 D-loop; other site 266779012904 H-loop/switch region; other site 266779012905 TOBE domain; Region: TOBE_2; pfam08402 266779012906 sorbitol dehydrogenase; Provisional; Region: PRK07067 266779012907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266779012908 NAD(P) binding site [chemical binding]; other site 266779012909 active site 266779012910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266779012911 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266779012912 NAD(P) binding site [chemical binding]; other site 266779012913 active site 266779012914 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266779012915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266779012916 active site 266779012917 motif I; other site 266779012918 motif II; other site 266779012919 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 266779012920 N- and C-terminal domain interface [polypeptide binding]; other site 266779012921 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 266779012922 active site 266779012923 MgATP binding site [chemical binding]; other site 266779012924 catalytic site [active] 266779012925 metal binding site [ion binding]; metal-binding site 266779012926 carbohydrate binding site [chemical binding]; other site 266779012927 putative homodimer interface [polypeptide binding]; other site 266779012928 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 266779012929 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 266779012930 active site residue [active] 266779012931 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 266779012932 active site residue [active] 266779012933 Sulphur transport; Region: Sulf_transp; pfam04143 266779012934 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 266779012935 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 266779012936 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 266779012937 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 266779012938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779012939 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266779012940 Walker A motif; other site 266779012941 ATP binding site [chemical binding]; other site 266779012942 Walker B motif; other site 266779012943 arginine finger; other site 266779012944 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 266779012945 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 266779012946 active site 266779012947 catalytic triad [active] 266779012948 replicative DNA helicase; Provisional; Region: PRK05973 266779012949 Catalytic domain of type IIs restriction endonuclease BfiI and similar proteins; Region: PLDc_Bfil; cd09175 266779012950 homodimer interface [polypeptide binding]; other site 266779012951 PLD-like domain; Region: PLDc_2; pfam13091 266779012952 putative active site [active] 266779012953 catalytic site [active] 266779012954 C-terminal domain of type IIs restriction endonuclease BfiI and similar proteins; Region: BfiI_C; cd10018 266779012955 putative DNA binding site [nucleotide binding]; other site 266779012956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266779012957 DNA methylase; Region: N6_N4_Mtase; cl17433 266779012958 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 266779012959 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266779012960 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 266779012961 catalytic residues [active] 266779012962 catalytic nucleophile [active] 266779012963 Recombinase; Region: Recombinase; pfam07508 266779012964 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 266779012965 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266779012966 active site 266779012967 DNA binding site [nucleotide binding] 266779012968 Int/Topo IB signature motif; other site 266779012969 Uncharacterized conserved protein [Function unknown]; Region: COG4544 266779012970 DNA Polymerase Y-family; Region: PolY_like; cd03468 266779012971 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 266779012972 DNA binding site [nucleotide binding] 266779012973 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 266779012974 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 266779012975 putative active site [active] 266779012976 putative PHP Thumb interface [polypeptide binding]; other site 266779012977 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 266779012978 generic binding surface I; other site 266779012979 generic binding surface II; other site 266779012980 DNA polymerase IV; Validated; Region: PRK03858 266779012981 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 266779012982 active site 266779012983 DNA binding site [nucleotide binding] 266779012984 Uncharacterized conserved protein [Function unknown]; Region: COG2135 266779012985 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 266779012986 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 266779012987 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 266779012988 hypothetical protein; Region: PHA00684 266779012989 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 266779012990 Antirestriction protein; Region: Antirestrict; pfam03230 266779012991 Methyltransferase domain; Region: Methyltransf_26; pfam13659 266779012992 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 266779012993 Helicase_C-like; Region: Helicase_C_4; pfam13871 266779012994 Toprim domain; Region: Toprim_3; pfam13362 266779012995 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 266779012996 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 266779012997 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 266779012998 dimer interface [polypeptide binding]; other site 266779012999 ssDNA binding site [nucleotide binding]; other site 266779013000 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266779013001 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 266779013002 Phage-related protein [Function unknown]; Region: COG4679 266779013003 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266779013004 non-specific DNA binding site [nucleotide binding]; other site 266779013005 salt bridge; other site 266779013006 sequence-specific DNA binding site [nucleotide binding]; other site 266779013007 Helix-turn-helix domain; Region: HTH_17; pfam12728 266779013008 Replication initiator protein A; Region: RPA; pfam10134 266779013009 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 266779013010 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 266779013011 DNA methylase; Region: N6_N4_Mtase; pfam01555 266779013012 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 266779013013 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 266779013014 Protein of unknown function (DUF736); Region: DUF736; pfam05284 266779013015 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266779013016 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266779013017 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266779013018 catalytic residue [active] 266779013019 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 266779013020 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 266779013021 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 266779013022 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 266779013023 Walker A motif; other site 266779013024 ATP binding site [chemical binding]; other site 266779013025 Walker B motif; other site 266779013026 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 266779013027 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266779013028 ATP binding site [chemical binding]; other site 266779013029 Walker A motif; other site 266779013030 hexamer interface [polypeptide binding]; other site 266779013031 Walker B motif; other site 266779013032 TrbC/VIRB2 family; Region: TrbC; pfam04956 266779013033 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 266779013034 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 266779013035 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266779013036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779013037 Walker A/P-loop; other site 266779013038 ATP binding site [chemical binding]; other site 266779013039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779013040 Walker B; other site 266779013041 D-loop; other site 266779013042 H-loop/switch region; other site 266779013043 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 266779013044 conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360 266779013045 conjugal transfer protein TrbL; Provisional; Region: PRK13875 266779013046 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 266779013047 conjugal transfer protein TrbF; Provisional; Region: PRK13872 266779013048 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266779013049 VirB7 interaction site; other site 266779013050 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 266779013051 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 266779013052 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779013053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779013054 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266779013055 dimerization interface [polypeptide binding]; other site 266779013056 substrate binding pocket [chemical binding]; other site 266779013057 RNA polymerase sigma factor, SigZ family; Region: SigZ; TIGR02959 266779013058 EamA-like transporter family; Region: EamA; pfam00892 266779013059 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266779013060 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266779013061 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 266779013062 ligand binding site [chemical binding]; other site 266779013063 flexible hinge region; other site 266779013064 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266779013065 putative switch regulator; other site 266779013066 non-specific DNA interactions [nucleotide binding]; other site 266779013067 DNA binding site [nucleotide binding] 266779013068 sequence specific DNA binding site [nucleotide binding]; other site 266779013069 putative cAMP binding site [chemical binding]; other site 266779013070 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 266779013071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 266779013072 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 266779013073 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266779013074 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 266779013075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266779013076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779013077 S-adenosylmethionine binding site [chemical binding]; other site 266779013078 Domain of unknown function (DUF305); Region: DUF305; cl17794 266779013079 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 266779013080 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 266779013081 putative substrate binding site [chemical binding]; other site 266779013082 nucleotide binding site [chemical binding]; other site 266779013083 nucleotide binding site [chemical binding]; other site 266779013084 homodimer interface [polypeptide binding]; other site 266779013085 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266779013086 Ligand Binding Site [chemical binding]; other site 266779013087 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 266779013088 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266779013089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266779013090 motif II; other site 266779013091 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 266779013092 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 266779013093 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266779013094 active site 266779013095 XFP N-terminal domain; Region: XFP_N; pfam09364 266779013096 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 266779013097 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 266779013098 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266779013099 Beta-Casp domain; Region: Beta-Casp; smart01027 266779013100 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 266779013101 thymidine phosphorylase; Provisional; Region: PRK04350 266779013102 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 266779013103 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 266779013104 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 266779013105 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 266779013106 Multicopper oxidase; Region: Cu-oxidase; pfam00394 266779013107 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 266779013108 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 266779013109 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PRK04207 266779013110 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 266779013111 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 266779013112 ABC1 family; Region: ABC1; cl17513 266779013113 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 266779013114 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 266779013115 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 266779013116 putative active site [active] 266779013117 catalytic site [active] 266779013118 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 266779013119 putative active site [active] 266779013120 catalytic site [active] 266779013121 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266779013122 D-Lactate and related Dehydrogenase like proteins, NAD-binding and catalytic domains; Region: LDH_like_1; cd12187 266779013123 ligand binding site [chemical binding]; other site 266779013124 NAD binding site [chemical binding]; other site 266779013125 homodimer interface [polypeptide binding]; other site 266779013126 catalytic site [active] 266779013127 FOG: CBS domain [General function prediction only]; Region: COG0517 266779013128 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 266779013129 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266779013130 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 266779013131 Predicted metal-binding protein [General function prediction only]; Region: COG3019 266779013132 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 266779013133 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 266779013134 DNA binding residues [nucleotide binding] 266779013135 dimer interface [polypeptide binding]; other site 266779013136 copper binding site [ion binding]; other site 266779013137 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266779013138 metal-binding site [ion binding] 266779013139 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266779013140 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266779013141 metal-binding site [ion binding] 266779013142 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266779013143 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 266779013144 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266779013145 metal-binding site [ion binding] 266779013146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 266779013147 Domain of unknown function (DUF305); Region: DUF305; cl17794 266779013148 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 266779013149 NADH(P)-binding; Region: NAD_binding_10; pfam13460 266779013150 NAD(P) binding site [chemical binding]; other site 266779013151 putative active site [active] 266779013152 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 266779013153 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 266779013154 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266779013155 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 266779013156 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266779013157 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266779013158 active site 266779013159 catalytic tetrad [active] 266779013160 short chain dehydrogenase; Provisional; Region: PRK06180 266779013161 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266779013162 NADP binding site [chemical binding]; other site 266779013163 active site 266779013164 steroid binding site; other site 266779013165 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 266779013166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266779013167 NAD(P) binding site [chemical binding]; other site 266779013168 active site 266779013169 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266779013170 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266779013171 active site 266779013172 catalytic tetrad [active] 266779013173 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266779013174 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266779013175 active site 266779013176 catalytic tetrad [active] 266779013177 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266779013178 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266779013179 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266779013180 putative effector binding pocket; other site 266779013181 putative dimerization interface [polypeptide binding]; other site 266779013182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266779013183 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 266779013184 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 266779013185 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 266779013186 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 266779013187 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 266779013188 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266779013189 catalytic site [active] 266779013190 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 266779013191 active site 266779013192 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 266779013193 Glycoprotease family; Region: Peptidase_M22; pfam00814 266779013194 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266779013195 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266779013196 Coenzyme A binding pocket [chemical binding]; other site 266779013197 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266779013198 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266779013199 putative acyl-acceptor binding pocket; other site 266779013200 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 266779013201 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 266779013202 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266779013203 FeS/SAM binding site; other site 266779013204 TRAM domain; Region: TRAM; cl01282 266779013205 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 266779013206 PhoH-like protein; Region: PhoH; pfam02562 266779013207 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 266779013208 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 266779013209 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266779013210 Transporter associated domain; Region: CorC_HlyC; smart01091 266779013211 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266779013212 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266779013213 non-specific DNA binding site [nucleotide binding]; other site 266779013214 salt bridge; other site 266779013215 sequence-specific DNA binding site [nucleotide binding]; other site 266779013216 S-adenosylmethionine synthetase; Validated; Region: PRK05250 266779013217 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 266779013218 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 266779013219 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 266779013220 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 266779013221 ribosome maturation protein RimP; Reviewed; Region: PRK00092 266779013222 Sm and related proteins; Region: Sm_like; cl00259 266779013223 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 266779013224 putative oligomer interface [polypeptide binding]; other site 266779013225 putative RNA binding site [nucleotide binding]; other site 266779013226 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 266779013227 NusA N-terminal domain; Region: NusA_N; pfam08529 266779013228 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 266779013229 RNA binding site [nucleotide binding]; other site 266779013230 homodimer interface [polypeptide binding]; other site 266779013231 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 266779013232 G-X-X-G motif; other site 266779013233 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 266779013234 G-X-X-G motif; other site 266779013235 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 266779013236 hypothetical protein; Provisional; Region: PRK09190 266779013237 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 266779013238 putative RNA binding cleft [nucleotide binding]; other site 266779013239 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 266779013240 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 266779013241 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 266779013242 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 266779013243 G1 box; other site 266779013244 putative GEF interaction site [polypeptide binding]; other site 266779013245 GTP/Mg2+ binding site [chemical binding]; other site 266779013246 Switch I region; other site 266779013247 G2 box; other site 266779013248 G3 box; other site 266779013249 Switch II region; other site 266779013250 G4 box; other site 266779013251 G5 box; other site 266779013252 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 266779013253 Translation-initiation factor 2; Region: IF-2; pfam11987 266779013254 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 266779013255 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 266779013256 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 266779013257 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 266779013258 RNA binding site [nucleotide binding]; other site 266779013259 active site 266779013260 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 266779013261 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266779013262 HWE histidine kinase; Region: HWE_HK; smart00911 266779013263 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 266779013264 16S/18S rRNA binding site [nucleotide binding]; other site 266779013265 S13e-L30e interaction site [polypeptide binding]; other site 266779013266 25S rRNA binding site [nucleotide binding]; other site 266779013267 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 266779013268 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 266779013269 RNase E interface [polypeptide binding]; other site 266779013270 trimer interface [polypeptide binding]; other site 266779013271 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 266779013272 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 266779013273 RNase E interface [polypeptide binding]; other site 266779013274 trimer interface [polypeptide binding]; other site 266779013275 active site 266779013276 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 266779013277 putative nucleic acid binding region [nucleotide binding]; other site 266779013278 G-X-X-G motif; other site 266779013279 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 266779013280 RNA binding site [nucleotide binding]; other site 266779013281 domain interface; other site 266779013282 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 266779013283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779013284 S-adenosylmethionine binding site [chemical binding]; other site 266779013285 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 266779013286 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 266779013287 NAD binding site [chemical binding]; other site 266779013288 homotetramer interface [polypeptide binding]; other site 266779013289 homodimer interface [polypeptide binding]; other site 266779013290 substrate binding site [chemical binding]; other site 266779013291 active site 266779013292 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 266779013293 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266779013294 dimer interface [polypeptide binding]; other site 266779013295 active site 266779013296 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 266779013297 active site 1 [active] 266779013298 dimer interface [polypeptide binding]; other site 266779013299 active site 2 [active] 266779013300 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266779013301 metal binding site 2 [ion binding]; metal-binding site 266779013302 putative DNA binding helix; other site 266779013303 metal binding site 1 [ion binding]; metal-binding site 266779013304 dimer interface [polypeptide binding]; other site 266779013305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 266779013306 Bacterial SH3 domain; Region: SH3_4; pfam06347 266779013307 Bacterial SH3 domain; Region: SH3_4; pfam06347 266779013308 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266779013309 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 266779013310 dimerization interface [polypeptide binding]; other site 266779013311 ligand binding site [chemical binding]; other site 266779013312 NADP binding site [chemical binding]; other site 266779013313 catalytic site [active] 266779013314 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 266779013315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266779013316 putative substrate translocation pore; other site 266779013317 DNA polymerase I; Provisional; Region: PRK05755 266779013318 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 266779013319 active site 266779013320 metal binding site 1 [ion binding]; metal-binding site 266779013321 putative 5' ssDNA interaction site; other site 266779013322 metal binding site 3; metal-binding site 266779013323 metal binding site 2 [ion binding]; metal-binding site 266779013324 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 266779013325 putative DNA binding site [nucleotide binding]; other site 266779013326 putative metal binding site [ion binding]; other site 266779013327 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 266779013328 active site 266779013329 catalytic site [active] 266779013330 substrate binding site [chemical binding]; other site 266779013331 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 266779013332 active site 266779013333 DNA binding site [nucleotide binding] 266779013334 catalytic site [active] 266779013335 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266779013336 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 266779013337 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 266779013338 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266779013339 metal binding site 2 [ion binding]; metal-binding site 266779013340 putative DNA binding helix; other site 266779013341 metal binding site 1 [ion binding]; metal-binding site 266779013342 dimer interface [polypeptide binding]; other site 266779013343 structural Zn2+ binding site [ion binding]; other site 266779013344 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266779013345 AsnC family; Region: AsnC_trans_reg; pfam01037 266779013346 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 266779013347 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 266779013348 NlpC/P60 family; Region: NLPC_P60; cl17555 266779013349 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266779013350 MarR family; Region: MarR; pfam01047 266779013351 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 266779013352 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 266779013353 interface (dimer of trimers) [polypeptide binding]; other site 266779013354 Substrate-binding/catalytic site; other site 266779013355 Zn-binding sites [ion binding]; other site 266779013356 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 266779013357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266779013358 TPR motif; other site 266779013359 binding surface 266779013360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266779013361 binding surface 266779013362 TPR motif; other site 266779013363 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266779013364 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266779013365 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266779013366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779013367 Walker A/P-loop; other site 266779013368 ATP binding site [chemical binding]; other site 266779013369 Q-loop/lid; other site 266779013370 ABC transporter signature motif; other site 266779013371 Walker B; other site 266779013372 D-loop; other site 266779013373 H-loop/switch region; other site 266779013374 TOBE domain; Region: TOBE_2; pfam08402 266779013375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779013376 dimer interface [polypeptide binding]; other site 266779013377 conserved gate region; other site 266779013378 putative PBP binding loops; other site 266779013379 ABC-ATPase subunit interface; other site 266779013380 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266779013381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779013382 dimer interface [polypeptide binding]; other site 266779013383 conserved gate region; other site 266779013384 putative PBP binding loops; other site 266779013385 ABC-ATPase subunit interface; other site 266779013386 Bacterial SH3 domain; Region: SH3_3; pfam08239 266779013387 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 266779013388 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 266779013389 OpgC protein; Region: OpgC_C; pfam10129 266779013390 ornithine cyclodeaminase; Validated; Region: PRK07589 266779013391 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266779013392 Arginase family; Region: Arginase; cd09989 266779013393 active site 266779013394 Mn binding site [ion binding]; other site 266779013395 oligomer interface [polypeptide binding]; other site 266779013396 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266779013397 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 266779013398 AsnC family; Region: AsnC_trans_reg; pfam01037 266779013399 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 266779013400 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 266779013401 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266779013402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266779013403 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266779013404 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266779013405 DNA-binding site [nucleotide binding]; DNA binding site 266779013406 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266779013407 FCD domain; Region: FCD; pfam07729 266779013408 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 266779013409 galactarate dehydratase; Region: galactar-dH20; TIGR03248 266779013410 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 266779013411 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266779013412 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266779013413 inhibitor site; inhibition site 266779013414 active site 266779013415 dimer interface [polypeptide binding]; other site 266779013416 catalytic residue [active] 266779013417 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 266779013418 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 266779013419 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 266779013420 shikimate binding site; other site 266779013421 NAD(P) binding site [chemical binding]; other site 266779013422 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 266779013423 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 266779013424 inhibitor-cofactor binding pocket; inhibition site 266779013425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266779013426 catalytic residue [active] 266779013427 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 266779013428 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266779013429 NAD(P) binding site [chemical binding]; other site 266779013430 catalytic residues [active] 266779013431 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266779013432 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266779013433 Walker A/P-loop; other site 266779013434 ATP binding site [chemical binding]; other site 266779013435 Q-loop/lid; other site 266779013436 ABC transporter signature motif; other site 266779013437 Walker B; other site 266779013438 D-loop; other site 266779013439 H-loop/switch region; other site 266779013440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779013441 dimer interface [polypeptide binding]; other site 266779013442 conserved gate region; other site 266779013443 putative PBP binding loops; other site 266779013444 ABC-ATPase subunit interface; other site 266779013445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779013446 putative PBP binding loops; other site 266779013447 dimer interface [polypeptide binding]; other site 266779013448 ABC-ATPase subunit interface; other site 266779013449 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266779013450 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266779013451 substrate binding pocket [chemical binding]; other site 266779013452 membrane-bound complex binding site; other site 266779013453 hinge residues; other site 266779013454 Uncharacterized conserved protein [Function unknown]; Region: COG5476 266779013455 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 266779013456 MlrC C-terminus; Region: MlrC_C; pfam07171 266779013457 methionine sulfoxide reductase A; Provisional; Region: PRK00058 266779013458 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 266779013459 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 266779013460 ligand binding site [chemical binding]; other site 266779013461 hypothetical protein; Validated; Region: PRK09104 266779013462 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 266779013463 metal binding site [ion binding]; metal-binding site 266779013464 putative dimer interface [polypeptide binding]; other site 266779013465 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 266779013466 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 266779013467 catalytic site [active] 266779013468 putative active site [active] 266779013469 putative substrate binding site [chemical binding]; other site 266779013470 CHASE4 domain; Region: CHASE4; pfam05228 266779013471 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266779013472 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266779013473 metal binding site [ion binding]; metal-binding site 266779013474 active site 266779013475 I-site; other site 266779013476 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266779013477 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 266779013478 Transglycosylase; Region: Transgly; pfam00912 266779013479 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 266779013480 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266779013481 classical (c) SDRs; Region: SDR_c; cd05233 266779013482 NAD(P) binding site [chemical binding]; other site 266779013483 active site 266779013484 Protein required for attachment to host cells; Region: Host_attach; pfam10116 266779013485 siroheme synthase; Provisional; Region: cysG; PRK10637 266779013486 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 266779013487 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 266779013488 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 266779013489 active site 266779013490 SAM binding site [chemical binding]; other site 266779013491 homodimer interface [polypeptide binding]; other site 266779013492 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 266779013493 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 266779013494 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266779013495 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266779013496 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 266779013497 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 266779013498 Active Sites [active] 266779013499 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 266779013500 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 266779013501 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 266779013502 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 266779013503 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 266779013504 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266779013505 BON domain; Region: BON; pfam04972 266779013506 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266779013507 Type IV pili component [Cell motility and secretion]; Region: COG5461 266779013508 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 266779013509 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 266779013510 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 266779013511 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 266779013512 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 266779013513 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266779013514 ATP binding site [chemical binding]; other site 266779013515 Walker A motif; other site 266779013516 hexamer interface [polypeptide binding]; other site 266779013517 Walker B motif; other site 266779013518 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 266779013519 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266779013520 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 266779013521 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266779013522 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266779013523 metal binding site 2 [ion binding]; metal-binding site 266779013524 putative DNA binding helix; other site 266779013525 metal binding site 1 [ion binding]; metal-binding site 266779013526 dimer interface [polypeptide binding]; other site 266779013527 structural Zn2+ binding site [ion binding]; other site 266779013528 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 266779013529 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266779013530 ABC-ATPase subunit interface; other site 266779013531 dimer interface [polypeptide binding]; other site 266779013532 putative PBP binding regions; other site 266779013533 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 266779013534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779013535 Walker A/P-loop; other site 266779013536 ATP binding site [chemical binding]; other site 266779013537 Q-loop/lid; other site 266779013538 ABC transporter signature motif; other site 266779013539 Walker B; other site 266779013540 D-loop; other site 266779013541 H-loop/switch region; other site 266779013542 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 266779013543 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 266779013544 metal binding site [ion binding]; metal-binding site 266779013545 CsbD-like; Region: CsbD; cl17424 266779013546 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266779013547 Cytochrome P450; Region: p450; cl12078 266779013548 hypothetical protein; Reviewed; Region: PRK12497 266779013549 Predicted methyltransferases [General function prediction only]; Region: COG0313 266779013550 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 266779013551 putative SAM binding site [chemical binding]; other site 266779013552 putative homodimer interface [polypeptide binding]; other site 266779013553 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266779013554 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 266779013555 putative ligand binding site [chemical binding]; other site 266779013556 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 266779013557 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266779013558 FeS/SAM binding site; other site 266779013559 HemN C-terminal domain; Region: HemN_C; pfam06969 266779013560 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 266779013561 active site 266779013562 dimerization interface [polypeptide binding]; other site 266779013563 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 266779013564 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266779013565 putative metal binding site [ion binding]; other site 266779013566 ribonuclease PH; Reviewed; Region: rph; PRK00173 266779013567 Ribonuclease PH; Region: RNase_PH_bact; cd11362 266779013568 hexamer interface [polypeptide binding]; other site 266779013569 active site 266779013570 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 266779013571 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 266779013572 heat shock protein GrpE; Provisional; Region: PRK14141 266779013573 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 266779013574 dimer interface [polypeptide binding]; other site 266779013575 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 266779013576 Predicted membrane protein [Function unknown]; Region: COG2860 266779013577 UPF0126 domain; Region: UPF0126; pfam03458 266779013578 UPF0126 domain; Region: UPF0126; pfam03458 266779013579 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 266779013580 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266779013581 substrate binding site [chemical binding]; other site 266779013582 ATP binding site [chemical binding]; other site 266779013583 CysZ-like protein; Reviewed; Region: PRK12768 266779013584 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266779013585 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266779013586 active site 266779013587 catalytic tetrad [active] 266779013588 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 266779013589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266779013590 motif II; other site 266779013591 Domain of unknown function DUF59; Region: DUF59; pfam01883 266779013592 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 266779013593 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 266779013594 Walker A motif; other site 266779013595 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266779013596 putative catalytic site [active] 266779013597 putative metal binding site [ion binding]; other site 266779013598 putative phosphate binding site [ion binding]; other site 266779013599 Predicted integral membrane protein [Function unknown]; Region: COG0392 266779013600 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 266779013601 putative active site [active] 266779013602 catalytic site [active] 266779013603 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 266779013604 PLD-like domain; Region: PLDc_2; pfam13091 266779013605 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266779013606 putative active site [active] 266779013607 putative active site [active] 266779013608 catalytic site [active] 266779013609 catalytic site [active] 266779013610 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 266779013611 Malic enzyme, N-terminal domain; Region: malic; pfam00390 266779013612 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 266779013613 putative NAD(P) binding site [chemical binding]; other site 266779013614 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 266779013615 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 266779013616 MutS domain I; Region: MutS_I; pfam01624 266779013617 MutS domain II; Region: MutS_II; pfam05188 266779013618 MutS domain III; Region: MutS_III; pfam05192 266779013619 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 266779013620 Walker A/P-loop; other site 266779013621 ATP binding site [chemical binding]; other site 266779013622 Q-loop/lid; other site 266779013623 ABC transporter signature motif; other site 266779013624 Walker B; other site 266779013625 D-loop; other site 266779013626 H-loop/switch region; other site 266779013627 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 266779013628 PII uridylyl-transferase; Provisional; Region: PRK05092 266779013629 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266779013630 metal binding triad; other site 266779013631 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 266779013632 HD domain; Region: HD; pfam01966 266779013633 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 266779013634 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 266779013635 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 266779013636 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 266779013637 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 266779013638 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 266779013639 active site 266779013640 HIGH motif; other site 266779013641 dimer interface [polypeptide binding]; other site 266779013642 KMSKS motif; other site 266779013643 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266779013644 Ligand Binding Site [chemical binding]; other site 266779013645 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 266779013646 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 266779013647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266779013648 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266779013649 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 266779013650 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 266779013651 DNA binding residues [nucleotide binding] 266779013652 dimer interface [polypeptide binding]; other site 266779013653 copper binding site [ion binding]; other site 266779013654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5321 266779013655 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 266779013656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779013657 active site 266779013658 phosphorylation site [posttranslational modification] 266779013659 intermolecular recognition site; other site 266779013660 dimerization interface [polypeptide binding]; other site 266779013661 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 266779013662 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266779013663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779013664 ATP binding site [chemical binding]; other site 266779013665 Mg2+ binding site [ion binding]; other site 266779013666 G-X-G motif; other site 266779013667 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 266779013668 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266779013669 ATP binding site [chemical binding]; other site 266779013670 putative Mg++ binding site [ion binding]; other site 266779013671 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266779013672 nucleotide binding region [chemical binding]; other site 266779013673 ATP-binding site [chemical binding]; other site 266779013674 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 266779013675 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 266779013676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266779013677 Walker A/P-loop; other site 266779013678 ATP binding site [chemical binding]; other site 266779013679 ABC transporter; Region: ABC_tran; pfam00005 266779013680 Q-loop/lid; other site 266779013681 AAA domain; Region: AAA_21; pfam13304 266779013682 ABC transporter signature motif; other site 266779013683 Walker B; other site 266779013684 D-loop; other site 266779013685 H-loop/switch region; other site 266779013686 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 266779013687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779013688 dimer interface [polypeptide binding]; other site 266779013689 conserved gate region; other site 266779013690 putative PBP binding loops; other site 266779013691 ABC-ATPase subunit interface; other site 266779013692 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 266779013693 hypothetical protein; Provisional; Region: PRK11622 266779013694 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 266779013695 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 266779013696 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 266779013697 heme binding site [chemical binding]; other site 266779013698 ferroxidase pore; other site 266779013699 ferroxidase diiron center [ion binding]; other site 266779013700 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779013701 dimerization interface [polypeptide binding]; other site 266779013702 putative DNA binding site [nucleotide binding]; other site 266779013703 putative Zn2+ binding site [ion binding]; other site 266779013704 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 266779013705 putative hydrophobic ligand binding site [chemical binding]; other site 266779013706 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 266779013707 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 266779013708 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 266779013709 active site 266779013710 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 266779013711 Ligand Binding Site [chemical binding]; other site 266779013712 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 266779013713 Flavoprotein; Region: Flavoprotein; pfam02441 266779013714 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 266779013715 hypothetical protein; Validated; Region: PRK00153 266779013716 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 266779013717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266779013718 Walker A motif; other site 266779013719 ATP binding site [chemical binding]; other site 266779013720 Walker B motif; other site 266779013721 arginine finger; other site 266779013722 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 266779013723 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 266779013724 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 266779013725 nucleotide binding site/active site [active] 266779013726 HIT family signature motif; other site 266779013727 catalytic residue [active] 266779013728 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 266779013729 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 266779013730 G1 box; other site 266779013731 putative GEF interaction site [polypeptide binding]; other site 266779013732 GTP/Mg2+ binding site [chemical binding]; other site 266779013733 Switch I region; other site 266779013734 G2 box; other site 266779013735 G3 box; other site 266779013736 Switch II region; other site 266779013737 G4 box; other site 266779013738 G5 box; other site 266779013739 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 266779013740 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266779013741 dimerization interface [polypeptide binding]; other site 266779013742 putative DNA binding site [nucleotide binding]; other site 266779013743 putative Zn2+ binding site [ion binding]; other site 266779013744 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 266779013745 putative hydrophobic ligand binding site [chemical binding]; other site 266779013746 CLM binding site; other site 266779013747 L1 loop; other site 266779013748 DNA binding site [nucleotide binding] 266779013749 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 266779013750 trimer interface [polypeptide binding]; other site 266779013751 active site 266779013752 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266779013753 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266779013754 tetramer interface [polypeptide binding]; other site 266779013755 active site 266779013756 Mg2+/Mn2+ binding site [ion binding]; other site 266779013757 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 266779013758 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 266779013759 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 266779013760 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 266779013761 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 266779013762 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 266779013763 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 266779013764 DctM-like transporters; Region: DctM; pfam06808 266779013765 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 266779013766 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 266779013767 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 266779013768 dimerization interface [polypeptide binding]; other site 266779013769 metal binding site [ion binding]; metal-binding site 266779013770 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 266779013771 diiron binding motif [ion binding]; other site 266779013772 Uncharacterized conserved protein [Function unknown]; Region: COG1633 266779013773 CCC1-related protein family; Region: CCC1_like_1; cd02437 266779013774 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 266779013775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266779013776 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 266779013777 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 266779013778 putative active site [active] 266779013779 putative metal binding residues [ion binding]; other site 266779013780 signature motif; other site 266779013781 putative dimer interface [polypeptide binding]; other site 266779013782 putative phosphate binding site [ion binding]; other site 266779013783 GTP-binding protein LepA; Provisional; Region: PRK05433 266779013784 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 266779013785 G1 box; other site 266779013786 putative GEF interaction site [polypeptide binding]; other site 266779013787 GTP/Mg2+ binding site [chemical binding]; other site 266779013788 Switch I region; other site 266779013789 G2 box; other site 266779013790 G3 box; other site 266779013791 Switch II region; other site 266779013792 G4 box; other site 266779013793 G5 box; other site 266779013794 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 266779013795 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 266779013796 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 266779013797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266779013798 dimer interface [polypeptide binding]; other site 266779013799 phosphorylation site [posttranslational modification] 266779013800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266779013801 ATP binding site [chemical binding]; other site 266779013802 G-X-G motif; other site 266779013803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266779013804 active site 266779013805 phosphorylation site [posttranslational modification] 266779013806 intermolecular recognition site; other site 266779013807 dimerization interface [polypeptide binding]; other site 266779013808 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266779013809 PAS domain; Region: PAS_9; pfam13426 266779013810 putative active site [active] 266779013811 heme pocket [chemical binding]; other site 266779013812 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266779013813 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 266779013814 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 266779013815 putative ligand binding site [chemical binding]; other site 266779013816 NAD binding site [chemical binding]; other site 266779013817 dimerization interface [polypeptide binding]; other site 266779013818 catalytic site [active] 266779013819 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 266779013820 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779013821 Walker A/P-loop; other site 266779013822 ATP binding site [chemical binding]; other site 266779013823 Q-loop/lid; other site 266779013824 ABC transporter signature motif; other site 266779013825 Walker B; other site 266779013826 D-loop; other site 266779013827 H-loop/switch region; other site 266779013828 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266779013829 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266779013830 Walker A/P-loop; other site 266779013831 ATP binding site [chemical binding]; other site 266779013832 Q-loop/lid; other site 266779013833 ABC transporter signature motif; other site 266779013834 Walker B; other site 266779013835 D-loop; other site 266779013836 H-loop/switch region; other site 266779013837 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 266779013838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779013839 dimer interface [polypeptide binding]; other site 266779013840 conserved gate region; other site 266779013841 ABC-ATPase subunit interface; other site 266779013842 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 266779013843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266779013844 dimer interface [polypeptide binding]; other site 266779013845 conserved gate region; other site 266779013846 putative PBP binding loops; other site 266779013847 ABC-ATPase subunit interface; other site 266779013848 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 266779013849 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 266779013850 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 266779013851 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 266779013852 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 266779013853 Cytochrome c2 [Energy production and conversion]; Region: COG3474 266779013854 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 266779013855 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 266779013856 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 266779013857 Ligand binding site; other site 266779013858 oligomer interface; other site 266779013859 prephenate dehydratase; Provisional; Region: PRK11899 266779013860 Prephenate dehydratase; Region: PDT; pfam00800 266779013861 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 266779013862 putative L-Phe binding site [chemical binding]; other site 266779013863 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266779013864 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 266779013865 dimer interface [polypeptide binding]; other site 266779013866 decamer (pentamer of dimers) interface [polypeptide binding]; other site 266779013867 catalytic triad [active] 266779013868 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 266779013869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266779013870 S-adenosylmethionine binding site [chemical binding]; other site 266779013871 ABC1 family; Region: ABC1; cl17513 266779013872 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 266779013873 recombination protein RecR; Reviewed; Region: recR; PRK00076 266779013874 RecR protein; Region: RecR; pfam02132 266779013875 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 266779013876 putative active site [active] 266779013877 putative metal-binding site [ion binding]; other site 266779013878 tetramer interface [polypeptide binding]; other site 266779013879 Transglycosylase SLT domain; Region: SLT_2; pfam13406 266779013880 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266779013881 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266779013882 catalytic residue [active] 266779013883 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266779013884 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 266779013885 Flp/Fap pilin component; Region: Flp_Fap; cl01585 266779013886 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266779013887 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266779013888 TadE-like protein; Region: TadE; pfam07811 266779013889 phosphopentomutase; Provisional; Region: PRK05362 266779013890 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 266779013891 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 266779013892 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 266779013893 DNA binding site [nucleotide binding] 266779013894 catalytic residue [active] 266779013895 H2TH interface [polypeptide binding]; other site 266779013896 putative catalytic residues [active] 266779013897 turnover-facilitating residue; other site 266779013898 intercalation triad [nucleotide binding]; other site 266779013899 8OG recognition residue [nucleotide binding]; other site 266779013900 putative reading head residues; other site 266779013901 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 266779013902 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 266779013903 enoyl-CoA hydratase; Provisional; Region: PRK05862 266779013904 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266779013905 substrate binding site [chemical binding]; other site 266779013906 oxyanion hole (OAH) forming residues; other site 266779013907 trimer interface [polypeptide binding]; other site 266779013908 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239