-- dump date 20140619_030414 -- class Genbank::misc_feature -- table misc_feature_note -- id note 590998000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 590998000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 590998000003 Walker A motif; other site 590998000004 ATP binding site [chemical binding]; other site 590998000005 Walker B motif; other site 590998000006 arginine finger; other site 590998000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 590998000008 DnaA box-binding interface [nucleotide binding]; other site 590998000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 590998000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 590998000011 putative DNA binding surface [nucleotide binding]; other site 590998000012 dimer interface [polypeptide binding]; other site 590998000013 beta-clamp/clamp loader binding surface; other site 590998000014 beta-clamp/translesion DNA polymerase binding surface; other site 590998000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 590998000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 590998000017 recombination protein F; Reviewed; Region: recF; PRK00064 590998000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998000019 Walker A/P-loop; other site 590998000020 ATP binding site [chemical binding]; other site 590998000021 Q-loop/lid; other site 590998000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998000023 ABC transporter signature motif; other site 590998000024 Walker B; other site 590998000025 D-loop; other site 590998000026 H-loop/switch region; other site 590998000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 590998000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 590998000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998000030 ATP binding site [chemical binding]; other site 590998000031 Mg2+ binding site [ion binding]; other site 590998000032 G-X-G motif; other site 590998000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 590998000034 anchoring element; other site 590998000035 dimer interface [polypeptide binding]; other site 590998000036 ATP binding site [chemical binding]; other site 590998000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 590998000038 active site 590998000039 putative metal-binding site [ion binding]; other site 590998000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 590998000041 DNA gyrase subunit A; Validated; Region: PRK05560 590998000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 590998000043 CAP-like domain; other site 590998000044 active site 590998000045 primary dimer interface [polypeptide binding]; other site 590998000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 590998000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 590998000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 590998000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 590998000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 590998000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 590998000052 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 590998000053 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 590998000054 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 590998000055 nodulation ABC transporter NodI; Provisional; Region: PRK13537 590998000056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998000057 Walker A/P-loop; other site 590998000058 ATP binding site [chemical binding]; other site 590998000059 Q-loop/lid; other site 590998000060 ABC transporter signature motif; other site 590998000061 Walker B; other site 590998000062 D-loop; other site 590998000063 H-loop/switch region; other site 590998000064 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 590998000065 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 590998000066 ABC-2 type transporter; Region: ABC2_membrane; cl17235 590998000067 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 590998000068 endoglucanase; Region: PLN02308 590998000069 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 590998000070 Cellulose binding domain; Region: CBM_3; pfam00942 590998000071 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 590998000072 Interdomain contacts; other site 590998000073 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 590998000074 Interdomain contacts; other site 590998000075 Cytokine receptor motif; other site 590998000076 Cellulose binding domain; Region: CBM_2; pfam00553 590998000077 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 590998000078 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 590998000079 active site 590998000080 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 590998000081 Zn2+ binding site [ion binding]; other site 590998000082 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 590998000083 putative septation inhibitor protein; Reviewed; Region: PRK02251 590998000084 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 590998000085 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 590998000086 active site 590998000087 catalytic site [active] 590998000088 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 590998000089 Glutamine amidotransferase class-I; Region: GATase; pfam00117 590998000090 glutamine binding [chemical binding]; other site 590998000091 catalytic triad [active] 590998000092 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 590998000093 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 590998000094 active site 590998000095 ATP binding site [chemical binding]; other site 590998000096 substrate binding site [chemical binding]; other site 590998000097 activation loop (A-loop); other site 590998000098 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 590998000099 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 590998000100 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 590998000101 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 590998000102 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 590998000103 Catalytic domain of Protein Kinases; Region: PKc; cd00180 590998000104 active site 590998000105 ATP binding site [chemical binding]; other site 590998000106 substrate binding site [chemical binding]; other site 590998000107 activation loop (A-loop); other site 590998000108 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 590998000109 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 590998000110 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 590998000111 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 590998000112 active site 590998000113 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 590998000114 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 590998000115 phosphopeptide binding site; other site 590998000116 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 590998000117 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 590998000118 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 590998000119 phosphopeptide binding site; other site 590998000120 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 590998000121 DEAD-like helicases superfamily; Region: DEXDc; smart00487 590998000122 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 590998000123 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 590998000124 Protein of unknown function DUF91; Region: DUF91; cl00709 590998000125 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 590998000126 putative hydrophobic ligand binding site [chemical binding]; other site 590998000127 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 590998000128 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 590998000129 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 590998000130 Interdomain contacts; other site 590998000131 Cytokine receptor motif; other site 590998000132 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 590998000133 Interdomain contacts; other site 590998000134 Cytokine receptor motif; other site 590998000135 Cellulose binding domain; Region: CBM_2; pfam00553 590998000136 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 590998000137 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 590998000138 Predicted membrane protein [Function unknown]; Region: COG1511 590998000139 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 590998000140 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 590998000141 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 590998000142 non-specific DNA binding site [nucleotide binding]; other site 590998000143 salt bridge; other site 590998000144 sequence-specific DNA binding site [nucleotide binding]; other site 590998000145 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 590998000146 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 590998000147 replicative DNA helicase; Region: DnaB; TIGR00665 590998000148 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 590998000149 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 590998000150 Walker A motif; other site 590998000151 ATP binding site [chemical binding]; other site 590998000152 Walker B motif; other site 590998000153 DNA binding loops [nucleotide binding] 590998000154 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998000155 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 590998000156 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 590998000157 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 590998000158 NAD(P) binding site [chemical binding]; other site 590998000159 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 590998000160 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 590998000161 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 590998000162 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 590998000163 oxidoreductase; Provisional; Region: PRK06128 590998000164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998000165 NAD(P) binding site [chemical binding]; other site 590998000166 active site 590998000167 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 590998000168 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 590998000169 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 590998000170 homotrimer interaction site [polypeptide binding]; other site 590998000171 putative active site [active] 590998000172 Major Facilitator Superfamily; Region: MFS_1; pfam07690 590998000173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998000174 putative substrate translocation pore; other site 590998000175 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 590998000176 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 590998000177 putative active site [active] 590998000178 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 590998000179 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 590998000180 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 590998000181 active site 590998000182 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 590998000183 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 590998000184 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 590998000185 active site 590998000186 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 590998000187 imidazolonepropionase; Provisional; Region: PRK14085 590998000188 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 590998000189 active site 590998000190 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 590998000191 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 590998000192 active site 590998000193 allantoate amidohydrolase; Reviewed; Region: PRK09290 590998000194 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 590998000195 active site 590998000196 metal binding site [ion binding]; metal-binding site 590998000197 dimer interface [polypeptide binding]; other site 590998000198 urocanate hydratase; Provisional; Region: PRK05414 590998000199 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 590998000200 active sites [active] 590998000201 tetramer interface [polypeptide binding]; other site 590998000202 Transcriptional regulator [Transcription]; Region: IclR; COG1414 590998000203 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998000204 putative DNA binding site [nucleotide binding]; other site 590998000205 putative Zn2+ binding site [ion binding]; other site 590998000206 Bacterial transcriptional regulator; Region: IclR; pfam01614 590998000207 Beta-lactamase; Region: Beta-lactamase; pfam00144 590998000208 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 590998000209 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 590998000210 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 590998000211 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 590998000212 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 590998000213 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 590998000214 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 590998000215 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 590998000216 homotrimer interaction site [polypeptide binding]; other site 590998000217 putative active site [active] 590998000218 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998000219 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998000220 DNA binding site [nucleotide binding] 590998000221 domain linker motif; other site 590998000222 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998000223 dimerization interface [polypeptide binding]; other site 590998000224 ligand binding site [chemical binding]; other site 590998000225 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998000226 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 590998000227 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 590998000228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998000229 dimer interface [polypeptide binding]; other site 590998000230 conserved gate region; other site 590998000231 putative PBP binding loops; other site 590998000232 ABC-ATPase subunit interface; other site 590998000233 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998000234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998000235 dimer interface [polypeptide binding]; other site 590998000236 conserved gate region; other site 590998000237 putative PBP binding loops; other site 590998000238 ABC-ATPase subunit interface; other site 590998000239 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 590998000240 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 590998000241 CBD_II domain; Region: CBD_II; smart00637 590998000242 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 590998000243 active site 590998000244 catalytic residues [active] 590998000245 Predicted membrane protein [General function prediction only]; Region: COG4194 590998000246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998000247 Walker A/P-loop; other site 590998000248 ATP binding site [chemical binding]; other site 590998000249 ABC transporter; Region: ABC_tran; pfam00005 590998000250 Q-loop/lid; other site 590998000251 ABC transporter signature motif; other site 590998000252 Walker B; other site 590998000253 D-loop; other site 590998000254 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 590998000255 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 590998000256 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 590998000257 hydrophobic ligand binding site; other site 590998000258 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 590998000259 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 590998000260 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 590998000261 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 590998000262 Walker A/P-loop; other site 590998000263 ATP binding site [chemical binding]; other site 590998000264 Q-loop/lid; other site 590998000265 ABC transporter signature motif; other site 590998000266 Walker B; other site 590998000267 D-loop; other site 590998000268 H-loop/switch region; other site 590998000269 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 590998000270 HSP90 family protein; Provisional; Region: PRK14083 590998000271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998000272 ATP binding site [chemical binding]; other site 590998000273 Mg2+ binding site [ion binding]; other site 590998000274 G-X-G motif; other site 590998000275 Tetratricopeptide repeat; Region: TPR_12; pfam13424 590998000276 Tetratricopeptide repeat; Region: TPR_12; pfam13424 590998000277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 590998000278 binding surface 590998000279 TPR motif; other site 590998000280 Tetratricopeptide repeat; Region: TPR_12; pfam13424 590998000281 Tetratricopeptide repeat; Region: TPR_12; pfam13424 590998000282 Tetratricopeptide repeat; Region: TPR_10; pfam13374 590998000283 Tetratricopeptide repeat; Region: TPR_12; pfam13424 590998000284 Tetratricopeptide repeat; Region: TPR_10; pfam13374 590998000285 Tetratricopeptide repeat; Region: TPR_12; pfam13424 590998000286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 590998000287 TPR motif; other site 590998000288 binding surface 590998000289 Tetratricopeptide repeat; Region: TPR_12; pfam13424 590998000290 Tetratricopeptide repeat; Region: TPR_12; pfam13424 590998000291 Tetratricopeptide repeat; Region: TPR_10; pfam13374 590998000292 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 590998000293 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 590998000294 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 590998000295 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 590998000296 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 590998000297 active site 590998000298 catalytic tetrad [active] 590998000299 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 590998000300 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 590998000301 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 590998000302 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 590998000303 Predicted transcriptional regulator [Transcription]; Region: COG2378 590998000304 HTH domain; Region: HTH_11; pfam08279 590998000305 WYL domain; Region: WYL; pfam13280 590998000306 Protein of unknown function (DUF664); Region: DUF664; pfam04978 590998000307 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 590998000308 active site 590998000309 substrate-binding site [chemical binding]; other site 590998000310 metal-binding site [ion binding] 590998000311 GTP binding site [chemical binding]; other site 590998000312 Domain of unknown function (DUF955); Region: DUF955; pfam06114 590998000313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998000314 dimer interface [polypeptide binding]; other site 590998000315 conserved gate region; other site 590998000316 putative PBP binding loops; other site 590998000317 ABC-ATPase subunit interface; other site 590998000318 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998000319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998000320 dimer interface [polypeptide binding]; other site 590998000321 conserved gate region; other site 590998000322 putative PBP binding loops; other site 590998000323 ABC-ATPase subunit interface; other site 590998000324 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998000325 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 590998000326 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 590998000327 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 590998000328 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 590998000329 PA/protease or protease-like domain interface [polypeptide binding]; other site 590998000330 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 590998000331 Peptidase family M28; Region: Peptidase_M28; pfam04389 590998000332 active site 590998000333 metal binding site [ion binding]; metal-binding site 590998000334 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 590998000335 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 590998000336 DNA binding residues [nucleotide binding] 590998000337 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 590998000338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998000339 putative substrate translocation pore; other site 590998000340 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 590998000341 YCII-related domain; Region: YCII; cl00999 590998000342 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 590998000343 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998000344 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 590998000345 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 590998000346 PspC domain; Region: PspC; pfam04024 590998000347 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 590998000348 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 590998000349 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 590998000350 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 590998000351 active site 590998000352 metal binding site [ion binding]; metal-binding site 590998000353 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 590998000354 PQQ-like domain; Region: PQQ_2; pfam13360 590998000355 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 590998000356 active site 590998000357 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 590998000358 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 590998000359 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 590998000360 ATP binding site [chemical binding]; other site 590998000361 putative Mg++ binding site [ion binding]; other site 590998000362 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 590998000363 nucleotide binding region [chemical binding]; other site 590998000364 ATP-binding site [chemical binding]; other site 590998000365 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 590998000366 putative hydrophobic ligand binding site [chemical binding]; other site 590998000367 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998000368 dimerization interface [polypeptide binding]; other site 590998000369 putative DNA binding site [nucleotide binding]; other site 590998000370 putative Zn2+ binding site [ion binding]; other site 590998000371 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 590998000372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998000373 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 590998000374 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 590998000375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 590998000376 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 590998000377 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998000378 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 590998000379 DNA binding residues [nucleotide binding] 590998000380 AAA ATPase domain; Region: AAA_16; pfam13191 590998000381 Walker A motif; other site 590998000382 ATP binding site [chemical binding]; other site 590998000383 Walker B motif; other site 590998000384 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 590998000385 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 590998000386 Nicotine adenine dinucleotide glycohydrolase (NADase); Region: NADase_NGA; pfam07461 590998000387 phage tail protein domain; Region: tail_TIGR02242 590998000388 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 590998000389 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 590998000390 Phage protein D [General function prediction only]; Region: COG3500 590998000391 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 590998000392 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 590998000393 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 590998000394 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 590998000395 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 590998000396 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 590998000397 Winged helix-turn helix; Region: HTH_29; pfam13551 590998000398 Integrase core domain; Region: rve; pfam00665 590998000399 Transposase; Region: HTH_Tnp_1; cl17663 590998000400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 590998000401 putative transposase OrfB; Reviewed; Region: PHA02517 590998000402 HTH-like domain; Region: HTH_21; pfam13276 590998000403 Integrase core domain; Region: rve; pfam00665 590998000404 Integrase core domain; Region: rve_3; cl15866 590998000405 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 590998000406 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 590998000407 Winged helix-turn helix; Region: HTH_29; pfam13551 590998000408 Integrase core domain; Region: rve; pfam00665 590998000409 Integrase core domain; Region: rve_3; pfam13683 590998000410 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 590998000411 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 590998000412 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 590998000413 DNA binding residues [nucleotide binding] 590998000414 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 590998000415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 590998000416 ATP binding site [chemical binding]; other site 590998000417 Walker A motif; other site 590998000418 Walker B motif; other site 590998000419 arginine finger; other site 590998000420 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 590998000421 translocation protein TolB; Provisional; Region: tolB; PRK04922 590998000422 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998000423 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998000424 DNA binding residues [nucleotide binding] 590998000425 dimerization interface [polypeptide binding]; other site 590998000426 Predicted membrane protein [Function unknown]; Region: COG1470 590998000427 PAAR motif; Region: PAAR_motif; pfam05488 590998000428 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 590998000429 FAD binding domain; Region: FAD_binding_4; pfam01565 590998000430 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 590998000431 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 590998000432 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 590998000433 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 590998000434 structural tetrad; other site 590998000435 FOG: WD40 repeat [General function prediction only]; Region: COG2319 590998000436 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 590998000437 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 590998000438 H+ Antiporter protein; Region: 2A0121; TIGR00900 590998000439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998000440 putative substrate translocation pore; other site 590998000441 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 590998000442 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 590998000443 active site 590998000444 catalytic tetrad [active] 590998000445 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 590998000446 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 590998000447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998000448 NAD(P) binding site [chemical binding]; other site 590998000449 active site 590998000450 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 590998000451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998000452 active site 590998000453 phosphorylation site [posttranslational modification] 590998000454 intermolecular recognition site; other site 590998000455 dimerization interface [polypeptide binding]; other site 590998000456 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 590998000457 DNA binding site [nucleotide binding] 590998000458 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 590998000459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 590998000460 dimer interface [polypeptide binding]; other site 590998000461 phosphorylation site [posttranslational modification] 590998000462 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 590998000463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998000464 ATP binding site [chemical binding]; other site 590998000465 G-X-G motif; other site 590998000466 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 590998000467 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 590998000468 Predicted membrane protein [Function unknown]; Region: COG2311 590998000469 Protein of unknown function (DUF418); Region: DUF418; pfam04235 590998000470 Predicted dehydrogenase [General function prediction only]; Region: COG5322 590998000471 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 590998000472 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 590998000473 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 590998000474 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 590998000475 putative metal binding site [ion binding]; other site 590998000476 hypothetical protein; Provisional; Region: PRK14013 590998000477 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 590998000478 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 590998000479 putative metal binding site [ion binding]; other site 590998000480 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 590998000481 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 590998000482 putative metal binding site [ion binding]; other site 590998000483 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 590998000484 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 590998000485 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 590998000486 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 590998000487 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 590998000488 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 590998000489 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 590998000490 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 590998000491 putative acyl-acceptor binding pocket; other site 590998000492 RDD family; Region: RDD; pfam06271 590998000493 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 590998000494 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 590998000495 CAAX protease self-immunity; Region: Abi; pfam02517 590998000496 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 590998000497 Transcriptional regulators [Transcription]; Region: MarR; COG1846 590998000498 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 590998000499 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 590998000500 Walker A/P-loop; other site 590998000501 ATP binding site [chemical binding]; other site 590998000502 Q-loop/lid; other site 590998000503 ABC transporter signature motif; other site 590998000504 Walker B; other site 590998000505 D-loop; other site 590998000506 H-loop/switch region; other site 590998000507 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 590998000508 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 590998000509 metal-binding site [ion binding] 590998000510 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 590998000511 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 590998000512 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 590998000513 metal-binding site [ion binding] 590998000514 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 590998000515 putative homodimer interface [polypeptide binding]; other site 590998000516 putative homotetramer interface [polypeptide binding]; other site 590998000517 putative allosteric switch controlling residues; other site 590998000518 putative metal binding site [ion binding]; other site 590998000519 putative homodimer-homodimer interface [polypeptide binding]; other site 590998000520 Predicted transcriptional regulator [Transcription]; Region: COG1959 590998000521 Transcriptional regulator; Region: Rrf2; pfam02082 590998000522 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 590998000523 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 590998000524 dimerization interface [polypeptide binding]; other site 590998000525 mannose binding site [chemical binding]; other site 590998000526 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 590998000527 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 590998000528 dimerization interface [polypeptide binding]; other site 590998000529 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 590998000530 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 590998000531 dimer interface [polypeptide binding]; other site 590998000532 putative CheW interface [polypeptide binding]; other site 590998000533 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 590998000534 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 590998000535 inhibitor-cofactor binding pocket; inhibition site 590998000536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998000537 catalytic residue [active] 590998000538 delta-aminolevulinic acid dehydratase; Validated; Region: PRK09283 590998000539 dimer interface [polypeptide binding]; other site 590998000540 active site 590998000541 Schiff base residues; other site 590998000542 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 590998000543 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 590998000544 domain interfaces; other site 590998000545 active site 590998000546 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 590998000547 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 590998000548 substrate binding site [chemical binding]; other site 590998000549 active site 590998000550 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 590998000551 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 590998000552 NAD(P) binding pocket [chemical binding]; other site 590998000553 adenylosuccinate lyase; Provisional; Region: PRK09285 590998000554 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 590998000555 tetramer interface [polypeptide binding]; other site 590998000556 active site 590998000557 Transcriptional regulator [Transcription]; Region: LysR; COG0583 590998000558 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 590998000559 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 590998000560 dimerization interface [polypeptide binding]; other site 590998000561 EamA-like transporter family; Region: EamA; pfam00892 590998000562 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 590998000563 Predicted membrane protein [Function unknown]; Region: COG1950 590998000564 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 590998000565 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 590998000566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998000567 homodimer interface [polypeptide binding]; other site 590998000568 catalytic residue [active] 590998000569 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 590998000570 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 590998000571 tetramer interface [polypeptide binding]; other site 590998000572 TPP-binding site [chemical binding]; other site 590998000573 heterodimer interface [polypeptide binding]; other site 590998000574 phosphorylation loop region [posttranslational modification] 590998000575 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 590998000576 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 590998000577 alpha subunit interface [polypeptide binding]; other site 590998000578 TPP binding site [chemical binding]; other site 590998000579 heterodimer interface [polypeptide binding]; other site 590998000580 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 590998000581 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 590998000582 E3 interaction surface; other site 590998000583 lipoyl attachment site [posttranslational modification]; other site 590998000584 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 590998000585 e3 binding domain; Region: E3_binding; pfam02817 590998000586 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 590998000587 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 590998000588 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 590998000589 iron-sulfur cluster [ion binding]; other site 590998000590 [2Fe-2S] cluster binding site [ion binding]; other site 590998000591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998000592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998000593 CopC domain; Region: CopC; pfam04234 590998000594 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 590998000595 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 590998000596 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 590998000597 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 590998000598 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 590998000599 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 590998000600 WYL domain; Region: WYL; pfam13280 590998000601 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 590998000602 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 590998000603 metal binding site [ion binding]; metal-binding site 590998000604 active site 590998000605 I-site; other site 590998000606 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 590998000607 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 590998000608 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 590998000609 Chitin binding domain; Region: Chitin_bind_3; pfam03067 590998000610 Cellulose binding domain; Region: CBM_2; cl17741 590998000611 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 590998000612 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 590998000613 nucleophile elbow; other site 590998000614 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 590998000615 putative acyl-acceptor binding pocket; other site 590998000616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 590998000617 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998000618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998000619 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 590998000620 DNA binding site [nucleotide binding] 590998000621 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 590998000622 homotrimer interaction site [polypeptide binding]; other site 590998000623 putative active site [active] 590998000624 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 590998000625 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 590998000626 active site 590998000627 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 590998000628 MarR family; Region: MarR; pfam01047 590998000629 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 590998000630 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 590998000631 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 590998000632 Walker A/P-loop; other site 590998000633 ATP binding site [chemical binding]; other site 590998000634 Q-loop/lid; other site 590998000635 ABC transporter signature motif; other site 590998000636 Walker B; other site 590998000637 D-loop; other site 590998000638 H-loop/switch region; other site 590998000639 Predicted transcriptional regulators [Transcription]; Region: COG1725 590998000640 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 590998000641 DNA-binding site [nucleotide binding]; DNA binding site 590998000642 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 590998000643 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 590998000644 NAD(P) binding site [chemical binding]; other site 590998000645 catalytic residues [active] 590998000646 Protein of unknown function (DUF779); Region: DUF779; cl01432 590998000647 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 590998000648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998000649 Walker A/P-loop; other site 590998000650 ATP binding site [chemical binding]; other site 590998000651 Q-loop/lid; other site 590998000652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998000653 ABC transporter signature motif; other site 590998000654 Walker B; other site 590998000655 D-loop; other site 590998000656 H-loop/switch region; other site 590998000657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998000658 Walker A/P-loop; other site 590998000659 ATP binding site [chemical binding]; other site 590998000660 Q-loop/lid; other site 590998000661 ABC transporter signature motif; other site 590998000662 Walker B; other site 590998000663 D-loop; other site 590998000664 H-loop/switch region; other site 590998000665 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 590998000666 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 590998000667 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 590998000668 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 590998000669 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 590998000670 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 590998000671 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 590998000672 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 590998000673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 590998000674 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 590998000675 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 590998000676 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 590998000677 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 590998000678 catalytic residue [active] 590998000679 TAP-like protein; Region: Abhydrolase_4; pfam08386 590998000680 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 590998000681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998000682 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 590998000683 Ligand Binding Site [chemical binding]; other site 590998000684 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 590998000685 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 590998000686 catalytic residue [active] 590998000687 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 590998000688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998000689 Walker A/P-loop; other site 590998000690 ATP binding site [chemical binding]; other site 590998000691 Q-loop/lid; other site 590998000692 ABC transporter signature motif; other site 590998000693 Walker B; other site 590998000694 D-loop; other site 590998000695 H-loop/switch region; other site 590998000696 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 590998000697 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 590998000698 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 590998000699 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 590998000700 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 590998000701 dimer interface [polypeptide binding]; other site 590998000702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998000703 catalytic residue [active] 590998000704 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 590998000705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998000706 S-adenosylmethionine binding site [chemical binding]; other site 590998000707 potential protein location (hypothetical protein Celf_0313 [Cellulomonas fimi ATCC 484]) that overlaps RNA (tRNA-G) 590998000708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 590998000709 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 590998000710 active site 590998000711 catalytic residues [active] 590998000712 Family description; Region: VCBS; pfam13517 590998000713 Family description; Region: VCBS; pfam13517 590998000714 Family description; Region: VCBS; pfam13517 590998000715 Bacterial Ig-like domain; Region: Big_5; pfam13205 590998000716 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 590998000717 active site 590998000718 catalytic residues [active] 590998000719 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 590998000720 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 590998000721 catalytic domain interface [polypeptide binding]; other site 590998000722 homodimer interface [polypeptide binding]; other site 590998000723 putative active site [active] 590998000724 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 590998000725 trimer interface [polypeptide binding]; other site 590998000726 active site 590998000727 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 590998000728 dimer interface [polypeptide binding]; other site 590998000729 ADP-ribose binding site [chemical binding]; other site 590998000730 active site 590998000731 nudix motif; other site 590998000732 metal binding site [ion binding]; metal-binding site 590998000733 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 590998000734 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 590998000735 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998000736 Walker A/P-loop; other site 590998000737 ATP binding site [chemical binding]; other site 590998000738 Q-loop/lid; other site 590998000739 ABC transporter signature motif; other site 590998000740 Walker B; other site 590998000741 D-loop; other site 590998000742 H-loop/switch region; other site 590998000743 MarR family; Region: MarR; pfam01047 590998000744 Beta-lactamase; Region: Beta-lactamase; pfam00144 590998000745 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 590998000746 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 590998000747 classical (c) SDRs; Region: SDR_c; cd05233 590998000748 NAD(P) binding site [chemical binding]; other site 590998000749 active site 590998000750 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 590998000751 Cysteine-rich domain; Region: CCG; pfam02754 590998000752 Cysteine-rich domain; Region: CCG; pfam02754 590998000753 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 590998000754 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 590998000755 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 590998000756 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 590998000757 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 590998000758 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 590998000759 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 590998000760 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 590998000761 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 590998000762 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 590998000763 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 590998000764 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 590998000765 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 590998000766 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 590998000767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998000768 dimer interface [polypeptide binding]; other site 590998000769 conserved gate region; other site 590998000770 putative PBP binding loops; other site 590998000771 ABC-ATPase subunit interface; other site 590998000772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998000773 ABC-ATPase subunit interface; other site 590998000774 putative PBP binding loops; other site 590998000775 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 590998000776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998000777 Walker A/P-loop; other site 590998000778 ATP binding site [chemical binding]; other site 590998000779 Q-loop/lid; other site 590998000780 ABC transporter signature motif; other site 590998000781 Walker B; other site 590998000782 D-loop; other site 590998000783 H-loop/switch region; other site 590998000784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998000785 Coenzyme A binding pocket [chemical binding]; other site 590998000786 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 590998000787 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 590998000788 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 590998000789 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 590998000790 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998000791 YCII-related domain; Region: YCII; cl00999 590998000792 Cellulose binding domain; Region: CBM_2; pfam00553 590998000793 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 590998000794 metal binding site [ion binding]; metal-binding site 590998000795 active site 590998000796 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998000797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998000798 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 590998000799 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 590998000800 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 590998000801 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 590998000802 ATP binding site [chemical binding]; other site 590998000803 substrate interface [chemical binding]; other site 590998000804 H+ Antiporter protein; Region: 2A0121; TIGR00900 590998000805 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 590998000806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 590998000807 non-specific DNA binding site [nucleotide binding]; other site 590998000808 salt bridge; other site 590998000809 sequence-specific DNA binding site [nucleotide binding]; other site 590998000810 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 590998000811 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 590998000812 Zn binding site [ion binding]; other site 590998000813 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 590998000814 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998000815 Lipase maturation factor; Region: LMF1; pfam06762 590998000816 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 590998000817 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998000818 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998000819 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998000820 dimerization interface [polypeptide binding]; other site 590998000821 putative DNA binding site [nucleotide binding]; other site 590998000822 putative Zn2+ binding site [ion binding]; other site 590998000823 H+ Antiporter protein; Region: 2A0121; TIGR00900 590998000824 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 590998000825 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 590998000826 catalytic site [active] 590998000827 Transmembrane secretion effector; Region: MFS_3; pfam05977 590998000828 hypothetical protein; Validated; Region: PRK00228 590998000829 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 590998000830 salt bridge; other site 590998000831 non-specific DNA binding site [nucleotide binding]; other site 590998000832 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 590998000833 sequence-specific DNA binding site [nucleotide binding]; other site 590998000834 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 590998000835 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 590998000836 Cellulose binding domain; Region: CBM_2; cl17741 590998000837 Catalytic NodB homology domain of Streptomyces lividans acetylxylan esterase and its bacterial homologs; Region: CE4_SlAXE_like; cd10953 590998000838 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 590998000839 NodB motif; other site 590998000840 active site 590998000841 catalytic site [active] 590998000842 Zn binding site [ion binding]; other site 590998000843 dimer interface [polypeptide binding]; other site 590998000844 Cellulose binding domain; Region: CBM_2; cl17741 590998000845 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 590998000846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998000847 Coenzyme A binding pocket [chemical binding]; other site 590998000848 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 590998000849 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 590998000850 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 590998000851 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 590998000852 NAD(P) binding site [chemical binding]; other site 590998000853 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 590998000854 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 590998000855 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 590998000856 putative active site [active] 590998000857 putative dimer interface [polypeptide binding]; other site 590998000858 Predicted flavoprotein [General function prediction only]; Region: COG0431 590998000859 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 590998000860 DinB superfamily; Region: DinB_2; pfam12867 590998000861 Protein of unknown function (DUF466); Region: DUF466; pfam04328 590998000862 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 590998000863 Carbon starvation protein CstA; Region: CstA; pfam02554 590998000864 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 590998000865 YCII-related domain; Region: YCII; cl00999 590998000866 maltose O-acetyltransferase; Provisional; Region: PRK10092 590998000867 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 590998000868 active site 590998000869 substrate binding site [chemical binding]; other site 590998000870 trimer interface [polypeptide binding]; other site 590998000871 CoA binding site [chemical binding]; other site 590998000872 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 590998000873 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 590998000874 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 590998000875 PilZ domain; Region: PilZ; pfam07238 590998000876 Epoxide hydrolase N terminus; Region: EHN; pfam06441 590998000877 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 590998000878 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 590998000879 putative hydrophobic ligand binding site [chemical binding]; other site 590998000880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998000881 putative DNA binding site [nucleotide binding]; other site 590998000882 Predicted transcriptional regulators [Transcription]; Region: COG1733 590998000883 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998000884 dimerization interface [polypeptide binding]; other site 590998000885 putative DNA binding site [nucleotide binding]; other site 590998000886 putative Zn2+ binding site [ion binding]; other site 590998000887 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 590998000888 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 590998000889 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 590998000890 putative sugar binding sites [chemical binding]; other site 590998000891 Q-X-W motif; other site 590998000892 Pectate lyase; Region: Pectate_lyase; pfam03211 590998000893 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 590998000894 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 590998000895 active site 590998000896 WYL domain; Region: WYL; pfam13280 590998000897 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 590998000898 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 590998000899 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 590998000900 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 590998000901 protein binding site [polypeptide binding]; other site 590998000902 Cellulose binding domain; Region: CBM_2; pfam00553 590998000903 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 590998000904 Cellulose binding domain; Region: CBM_2; pfam00553 590998000905 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 590998000906 putative hydrophobic ligand binding site [chemical binding]; other site 590998000907 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998000908 putative DNA binding site [nucleotide binding]; other site 590998000909 putative Zn2+ binding site [ion binding]; other site 590998000910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998000911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998000912 Predicted membrane protein [Function unknown]; Region: COG4270 590998000913 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 590998000914 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 590998000915 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 590998000916 Protein tyrosine phosphatase, catalytic domain motif; Region: PTPc_motif; smart00404 590998000917 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 590998000918 catalytic core [active] 590998000919 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 590998000920 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 590998000921 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 590998000922 putative metal binding site [ion binding]; other site 590998000923 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 590998000924 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 590998000925 putative metal binding site [ion binding]; other site 590998000926 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 590998000927 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 590998000928 putative metal binding site [ion binding]; other site 590998000929 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 590998000930 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 590998000931 DNA binding residues [nucleotide binding] 590998000932 drug binding residues [chemical binding]; other site 590998000933 dimer interface [polypeptide binding]; other site 590998000934 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 590998000935 beta-clamp/clamp loader binding surface; other site 590998000936 beta-clamp/translesion DNA polymerase binding surface; other site 590998000937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998000938 S-adenosylmethionine binding site [chemical binding]; other site 590998000939 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 590998000940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998000941 Walker A/P-loop; other site 590998000942 ATP binding site [chemical binding]; other site 590998000943 Q-loop/lid; other site 590998000944 ABC transporter signature motif; other site 590998000945 Walker B; other site 590998000946 D-loop; other site 590998000947 H-loop/switch region; other site 590998000948 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 590998000949 Histidine kinase; Region: HisKA_3; pfam07730 590998000950 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 590998000951 ATP binding site [chemical binding]; other site 590998000952 Mg2+ binding site [ion binding]; other site 590998000953 G-X-G motif; other site 590998000954 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998000955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998000956 active site 590998000957 phosphorylation site [posttranslational modification] 590998000958 intermolecular recognition site; other site 590998000959 dimerization interface [polypeptide binding]; other site 590998000960 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998000961 DNA binding residues [nucleotide binding] 590998000962 dimerization interface [polypeptide binding]; other site 590998000963 Predicted transcriptional regulator [Transcription]; Region: COG2378 590998000964 HTH domain; Region: HTH_11; pfam08279 590998000965 WYL domain; Region: WYL; pfam13280 590998000966 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 590998000967 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 590998000968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998000969 S-adenosylmethionine binding site [chemical binding]; other site 590998000970 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 590998000971 active site 590998000972 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 590998000973 DNA-binding site [nucleotide binding]; DNA binding site 590998000974 RNA-binding motif; other site 590998000975 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 590998000976 DNA-binding site [nucleotide binding]; DNA binding site 590998000977 RNA-binding motif; other site 590998000978 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 590998000979 DNA-binding site [nucleotide binding]; DNA binding site 590998000980 RNA-binding motif; other site 590998000981 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 590998000982 DNA-binding site [nucleotide binding]; DNA binding site 590998000983 RNA-binding motif; other site 590998000984 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 590998000985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998000986 S-adenosylmethionine binding site [chemical binding]; other site 590998000987 alpha-galactosidase; Region: PLN02808; cl17638 590998000988 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 590998000989 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 590998000990 putative sugar binding sites [chemical binding]; other site 590998000991 Q-X-W motif; other site 590998000992 hypothetical protein; Provisional; Region: PRK06761 590998000993 AAA domain; Region: AAA_18; pfam13238 590998000994 Epoxide hydrolase N terminus; Region: EHN; pfam06441 590998000995 Transcriptional regulators [Transcription]; Region: MarR; COG1846 590998000996 MarR family; Region: MarR_2; pfam12802 590998000997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998000998 Coenzyme A binding pocket [chemical binding]; other site 590998000999 putative phosphatase; Provisional; Region: PRK11587 590998001000 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 590998001001 HEAT repeats; Region: HEAT_2; pfam13646 590998001002 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 590998001003 hydrophobic ligand binding site; other site 590998001004 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 590998001005 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 590998001006 active site 590998001007 catalytic tetrad [active] 590998001008 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 590998001009 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 590998001010 putative trimer interface [polypeptide binding]; other site 590998001011 putative CoA binding site [chemical binding]; other site 590998001012 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 590998001013 Winged helix-turn helix; Region: HTH_29; pfam13551 590998001014 Integrase core domain; Region: rve; pfam00665 590998001015 Integrase core domain; Region: rve_3; pfam13683 590998001016 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 590998001017 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 590998001018 catalytic Zn binding site [ion binding]; other site 590998001019 NAD(P) binding site [chemical binding]; other site 590998001020 structural Zn binding site [ion binding]; other site 590998001021 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 590998001022 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 590998001023 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 590998001024 nucleotide binding site [chemical binding]; other site 590998001025 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 590998001026 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 590998001027 dimer interface [polypeptide binding]; other site 590998001028 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 590998001029 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 590998001030 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 590998001031 HSP70 interaction site [polypeptide binding]; other site 590998001032 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 590998001033 substrate binding site [polypeptide binding]; other site 590998001034 dimer interface [polypeptide binding]; other site 590998001035 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 590998001036 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 590998001037 DNA binding residues [nucleotide binding] 590998001038 putative dimer interface [polypeptide binding]; other site 590998001039 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 590998001040 nucleotide binding site [chemical binding]; other site 590998001041 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 590998001042 metal binding site [ion binding]; metal-binding site 590998001043 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 590998001044 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 590998001045 dimer interface [polypeptide binding]; other site 590998001046 phosphorylation site [posttranslational modification] 590998001047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998001048 ATP binding site [chemical binding]; other site 590998001049 Mg2+ binding site [ion binding]; other site 590998001050 G-X-G motif; other site 590998001051 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 590998001052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998001053 active site 590998001054 phosphorylation site [posttranslational modification] 590998001055 intermolecular recognition site; other site 590998001056 dimerization interface [polypeptide binding]; other site 590998001057 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 590998001058 DNA binding site [nucleotide binding] 590998001059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998001060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998001061 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 590998001062 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 590998001063 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 590998001064 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 590998001065 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 590998001066 substrate binding site [chemical binding]; other site 590998001067 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 590998001068 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 590998001069 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 590998001070 Walker A/P-loop; other site 590998001071 ATP binding site [chemical binding]; other site 590998001072 Q-loop/lid; other site 590998001073 ABC transporter signature motif; other site 590998001074 Walker B; other site 590998001075 D-loop; other site 590998001076 H-loop/switch region; other site 590998001077 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 590998001078 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 590998001079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998001080 dimer interface [polypeptide binding]; other site 590998001081 conserved gate region; other site 590998001082 putative PBP binding loops; other site 590998001083 ABC-ATPase subunit interface; other site 590998001084 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 590998001085 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 590998001086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998001087 putative PBP binding loops; other site 590998001088 dimer interface [polypeptide binding]; other site 590998001089 ABC-ATPase subunit interface; other site 590998001090 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 590998001091 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 590998001092 Walker A/P-loop; other site 590998001093 ATP binding site [chemical binding]; other site 590998001094 Q-loop/lid; other site 590998001095 ABC transporter signature motif; other site 590998001096 Walker B; other site 590998001097 D-loop; other site 590998001098 H-loop/switch region; other site 590998001099 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 590998001100 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 590998001101 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998001102 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 590998001103 YCII-related domain; Region: YCII; cl00999 590998001104 RibD C-terminal domain; Region: RibD_C; cl17279 590998001105 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 590998001106 active site 590998001107 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 590998001108 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 590998001109 active site 590998001110 interdomain interaction site; other site 590998001111 putative metal-binding site [ion binding]; other site 590998001112 nucleotide binding site [chemical binding]; other site 590998001113 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 590998001114 domain I; other site 590998001115 phosphate binding site [ion binding]; other site 590998001116 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 590998001117 domain II; other site 590998001118 domain III; other site 590998001119 nucleotide binding site [chemical binding]; other site 590998001120 DNA binding groove [nucleotide binding] 590998001121 catalytic site [active] 590998001122 domain IV; other site 590998001123 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 590998001124 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 590998001125 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 590998001126 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 590998001127 thymidylate kinase; Validated; Region: tmk; PRK00698 590998001128 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 590998001129 TMP-binding site; other site 590998001130 ATP-binding site [chemical binding]; other site 590998001131 DNA polymerase III subunit delta'; Validated; Region: PRK07940 590998001132 DNA polymerase III subunit delta'; Validated; Region: PRK08485 590998001133 RibD C-terminal domain; Region: RibD_C; cl17279 590998001134 TAP-like protein; Region: Abhydrolase_4; pfam08386 590998001135 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 590998001136 metal binding triad [ion binding]; metal-binding site 590998001137 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998001138 putative DNA binding site [nucleotide binding]; other site 590998001139 putative Zn2+ binding site [ion binding]; other site 590998001140 Predicted permeases [General function prediction only]; Region: COG0701 590998001141 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 590998001142 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 590998001143 catalytic residues [active] 590998001144 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 590998001145 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 590998001146 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 590998001147 Low molecular weight phosphatase family; Region: LMWPc; cl00105 590998001148 active site 590998001149 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 590998001150 amphipathic channel; other site 590998001151 Asn-Pro-Ala signature motifs; other site 590998001152 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 590998001153 YibE/F-like protein; Region: YibE_F; pfam07907 590998001154 YibE/F-like protein; Region: YibE_F; pfam07907 590998001155 hypothetical protein; Reviewed; Region: PRK09588 590998001156 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 590998001157 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 590998001158 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 590998001159 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998001160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998001161 active site 590998001162 phosphorylation site [posttranslational modification] 590998001163 intermolecular recognition site; other site 590998001164 dimerization interface [polypeptide binding]; other site 590998001165 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998001166 DNA binding residues [nucleotide binding] 590998001167 dimerization interface [polypeptide binding]; other site 590998001168 Histidine kinase; Region: HisKA_3; pfam07730 590998001169 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 590998001170 ATP binding site [chemical binding]; other site 590998001171 Mg2+ binding site [ion binding]; other site 590998001172 G-X-G motif; other site 590998001173 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 590998001174 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 590998001175 ATP-grasp domain; Region: ATP-grasp_4; cl17255 590998001176 alanine racemase; Reviewed; Region: alr; PRK00053 590998001177 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 590998001178 active site 590998001179 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 590998001180 dimer interface [polypeptide binding]; other site 590998001181 substrate binding site [chemical binding]; other site 590998001182 catalytic residues [active] 590998001183 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 590998001184 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 590998001185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998001186 putative substrate translocation pore; other site 590998001187 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 590998001188 nucleotide binding site [chemical binding]; other site 590998001189 AAA ATPase domain; Region: AAA_16; pfam13191 590998001190 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998001191 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998001192 DNA binding residues [nucleotide binding] 590998001193 dimerization interface [polypeptide binding]; other site 590998001194 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 590998001195 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 590998001196 active site 590998001197 metal binding site [ion binding]; metal-binding site 590998001198 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 590998001199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998001200 ATP binding site [chemical binding]; other site 590998001201 Mg2+ binding site [ion binding]; other site 590998001202 G-X-G motif; other site 590998001203 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 590998001204 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 590998001205 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 590998001206 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 590998001207 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 590998001208 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 590998001209 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 590998001210 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 590998001211 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 590998001212 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 590998001213 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 590998001214 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 590998001215 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cl08187 590998001216 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 590998001217 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998001218 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 590998001219 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 590998001220 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 590998001221 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 590998001222 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998001223 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 590998001224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998001225 dimer interface [polypeptide binding]; other site 590998001226 conserved gate region; other site 590998001227 putative PBP binding loops; other site 590998001228 ABC-ATPase subunit interface; other site 590998001229 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998001230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998001231 dimer interface [polypeptide binding]; other site 590998001232 conserved gate region; other site 590998001233 putative PBP binding loops; other site 590998001234 ABC-ATPase subunit interface; other site 590998001235 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998001236 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998001237 DNA binding site [nucleotide binding] 590998001238 domain linker motif; other site 590998001239 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 590998001240 putative dimerization interface [polypeptide binding]; other site 590998001241 putative ligand binding site [chemical binding]; other site 590998001242 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 590998001243 FtsX-like permease family; Region: FtsX; pfam02687 590998001244 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 590998001245 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 590998001246 Walker A/P-loop; other site 590998001247 ATP binding site [chemical binding]; other site 590998001248 Q-loop/lid; other site 590998001249 ABC transporter signature motif; other site 590998001250 Walker B; other site 590998001251 D-loop; other site 590998001252 H-loop/switch region; other site 590998001253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998001254 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 590998001255 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 590998001256 active site 590998001257 metal binding site 1 [ion binding]; metal-binding site 590998001258 putative 5' ssDNA interaction site; other site 590998001259 metal binding site 3; metal-binding site 590998001260 metal binding site 2 [ion binding]; metal-binding site 590998001261 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 590998001262 putative DNA binding site [nucleotide binding]; other site 590998001263 putative metal binding site [ion binding]; other site 590998001264 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 590998001265 RNA/DNA hybrid binding site [nucleotide binding]; other site 590998001266 active site 590998001267 Domain of unknown function (DUF3806); Region: DUF3806; pfam12713 590998001268 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 590998001269 putative active site [active] 590998001270 catalytic triad [active] 590998001271 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 590998001272 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13944 590998001273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998001274 S-adenosylmethionine binding site [chemical binding]; other site 590998001275 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 590998001276 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 590998001277 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 590998001278 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 590998001279 FAD binding domain; Region: FAD_binding_4; pfam01565 590998001280 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 590998001281 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 590998001282 Domain of unknown function DUF77; Region: DUF77; pfam01910 590998001283 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 590998001284 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 590998001285 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 590998001286 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 590998001287 NAD(P) binding site [chemical binding]; other site 590998001288 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 590998001289 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 590998001290 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 590998001291 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 590998001292 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 590998001293 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 590998001294 homodimer interface [polypeptide binding]; other site 590998001295 substrate-cofactor binding pocket; other site 590998001296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998001297 catalytic residue [active] 590998001298 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 590998001299 NlpC/P60 family; Region: NLPC_P60; pfam00877 590998001300 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 590998001301 dimer interface [polypeptide binding]; other site 590998001302 substrate binding site [chemical binding]; other site 590998001303 metal binding sites [ion binding]; metal-binding site 590998001304 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 590998001305 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 590998001306 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 590998001307 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 590998001308 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 590998001309 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 590998001310 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 590998001311 active site 590998001312 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 590998001313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 590998001314 Walker A motif; other site 590998001315 ATP binding site [chemical binding]; other site 590998001316 Walker B motif; other site 590998001317 arginine finger; other site 590998001318 Peptidase family M41; Region: Peptidase_M41; pfam01434 590998001319 GTP cyclohydrolase I; Provisional; Region: PLN03044 590998001320 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 590998001321 homodecamer interface [polypeptide binding]; other site 590998001322 active site 590998001323 putative catalytic site residues [active] 590998001324 zinc binding site [ion binding]; other site 590998001325 GTP-CH-I/GFRP interaction surface; other site 590998001326 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 590998001327 dihydropteroate synthase; Region: DHPS; TIGR01496 590998001328 substrate binding pocket [chemical binding]; other site 590998001329 dimer interface [polypeptide binding]; other site 590998001330 inhibitor binding site; inhibition site 590998001331 Dihydroneopterin aldolase; Region: FolB; smart00905 590998001332 active site 590998001333 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 590998001334 catalytic center binding site [active] 590998001335 ATP binding site [chemical binding]; other site 590998001336 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 590998001337 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 590998001338 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 590998001339 active site 590998001340 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 590998001341 active site 590998001342 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 590998001343 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 590998001344 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 590998001345 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998001346 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 590998001347 Uncharacterized conserved protein [Function unknown]; Region: COG3402 590998001348 Bacterial PH domain; Region: DUF304; pfam03703 590998001349 Bacterial PH domain; Region: DUF304; pfam03703 590998001350 Rossmann-like domain; Region: Rossmann-like; pfam10727 590998001351 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 590998001352 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 590998001353 active site 590998001354 nucleotide binding site [chemical binding]; other site 590998001355 HIGH motif; other site 590998001356 KMSKS motif; other site 590998001357 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 590998001358 tetramerization interface [polypeptide binding]; other site 590998001359 active site 590998001360 L-aspartate oxidase; Provisional; Region: PRK07804 590998001361 L-aspartate oxidase; Provisional; Region: PRK06175 590998001362 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 590998001363 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 590998001364 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 590998001365 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 590998001366 NodB motif; other site 590998001367 active site 590998001368 catalytic site [active] 590998001369 metal binding site [ion binding]; metal-binding site 590998001370 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 590998001371 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 590998001372 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 590998001373 Ca binding site [ion binding]; other site 590998001374 carbohydrate binding site [chemical binding]; other site 590998001375 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 590998001376 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 590998001377 dimerization interface [polypeptide binding]; other site 590998001378 active site 590998001379 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 590998001380 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 590998001381 dimer interface [polypeptide binding]; other site 590998001382 putative anticodon binding site; other site 590998001383 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 590998001384 motif 1; other site 590998001385 dimer interface [polypeptide binding]; other site 590998001386 active site 590998001387 motif 2; other site 590998001388 motif 3; other site 590998001389 Lsr2; Region: Lsr2; pfam11774 590998001390 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 590998001391 D-xylulose kinase; Region: XylB; TIGR01312 590998001392 nucleotide binding site [chemical binding]; other site 590998001393 xylose isomerase; Provisional; Region: PRK12677 590998001394 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 590998001395 Transcriptional regulators [Transcription]; Region: MarR; COG1846 590998001396 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 590998001397 putative switch regulator; other site 590998001398 non-specific DNA interactions [nucleotide binding]; other site 590998001399 DNA binding site [nucleotide binding] 590998001400 sequence specific DNA binding site [nucleotide binding]; other site 590998001401 putative cAMP binding site [chemical binding]; other site 590998001402 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 590998001403 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 590998001404 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 590998001405 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 590998001406 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 590998001407 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 590998001408 Calx-beta domain; Region: Calx-beta; cl02522 590998001409 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 590998001410 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 590998001411 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 590998001412 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 590998001413 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 590998001414 putative ADP-binding pocket [chemical binding]; other site 590998001415 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 590998001416 catalytic core [active] 590998001417 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 590998001418 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 590998001419 PhoU domain; Region: PhoU; pfam01895 590998001420 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 590998001421 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 590998001422 dimer interface [polypeptide binding]; other site 590998001423 phosphorylation site [posttranslational modification] 590998001424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998001425 ATP binding site [chemical binding]; other site 590998001426 Mg2+ binding site [ion binding]; other site 590998001427 G-X-G motif; other site 590998001428 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 590998001429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998001430 active site 590998001431 phosphorylation site [posttranslational modification] 590998001432 intermolecular recognition site; other site 590998001433 dimerization interface [polypeptide binding]; other site 590998001434 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 590998001435 DNA binding site [nucleotide binding] 590998001436 PBP superfamily domain; Region: PBP_like_2; cl17296 590998001437 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 590998001438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998001439 dimer interface [polypeptide binding]; other site 590998001440 conserved gate region; other site 590998001441 putative PBP binding loops; other site 590998001442 ABC-ATPase subunit interface; other site 590998001443 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 590998001444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998001445 dimer interface [polypeptide binding]; other site 590998001446 conserved gate region; other site 590998001447 putative PBP binding loops; other site 590998001448 ABC-ATPase subunit interface; other site 590998001449 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 590998001450 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 590998001451 Walker A/P-loop; other site 590998001452 ATP binding site [chemical binding]; other site 590998001453 Q-loop/lid; other site 590998001454 ABC transporter signature motif; other site 590998001455 Walker B; other site 590998001456 D-loop; other site 590998001457 H-loop/switch region; other site 590998001458 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 590998001459 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 590998001460 active site 590998001461 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cl10030 590998001462 homotrimer interaction site [polypeptide binding]; other site 590998001463 zinc binding site [ion binding]; other site 590998001464 CDP-binding sites; other site 590998001465 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 590998001466 Transcriptional regulator [Transcription]; Region: LysR; COG0583 590998001467 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 590998001468 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 590998001469 dimerization interface [polypeptide binding]; other site 590998001470 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 590998001471 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 590998001472 putative NAD(P) binding site [chemical binding]; other site 590998001473 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 590998001474 FAD binding domain; Region: FAD_binding_4; pfam01565 590998001475 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 590998001476 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998001477 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998001478 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 590998001479 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 590998001480 catalytic residue [active] 590998001481 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 590998001482 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 590998001483 active site 590998001484 HIGH motif; other site 590998001485 nucleotide binding site [chemical binding]; other site 590998001486 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 590998001487 KMSKS motif; other site 590998001488 tRNA binding surface [nucleotide binding]; other site 590998001489 anticodon binding site; other site 590998001490 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 590998001491 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 590998001492 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 590998001493 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 590998001494 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 590998001495 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 590998001496 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 590998001497 Walker A/P-loop; other site 590998001498 ATP binding site [chemical binding]; other site 590998001499 Q-loop/lid; other site 590998001500 ABC transporter signature motif; other site 590998001501 Walker B; other site 590998001502 D-loop; other site 590998001503 H-loop/switch region; other site 590998001504 TOBE domain; Region: TOBE; pfam03459 590998001505 PQQ-like domain; Region: PQQ_2; pfam13360 590998001506 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 590998001507 PQQ-like domain; Region: PQQ_2; pfam13360 590998001508 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 590998001509 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 590998001510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 590998001511 active site 590998001512 motif I; other site 590998001513 motif II; other site 590998001514 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 590998001515 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 590998001516 active site 590998001517 homotetramer interface [polypeptide binding]; other site 590998001518 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 590998001519 Catalytic domain of Protein Kinases; Region: PKc; cd00180 590998001520 active site 590998001521 ATP binding site [chemical binding]; other site 590998001522 substrate binding site [chemical binding]; other site 590998001523 activation loop (A-loop); other site 590998001524 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 590998001525 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 590998001526 catalytic residues [active] 590998001527 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 590998001528 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998001529 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998001530 DNA binding site [nucleotide binding] 590998001531 domain linker motif; other site 590998001532 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 590998001533 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998001534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998001535 active site 590998001536 phosphorylation site [posttranslational modification] 590998001537 intermolecular recognition site; other site 590998001538 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998001539 DNA binding residues [nucleotide binding] 590998001540 dimerization interface [polypeptide binding]; other site 590998001541 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 590998001542 ATP binding site [chemical binding]; other site 590998001543 Mg2+ binding site [ion binding]; other site 590998001544 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 590998001545 Catalytic site [active] 590998001546 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 590998001547 active site 590998001548 catalytic triad [active] 590998001549 oxyanion hole [active] 590998001550 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 590998001551 ligand binding site [chemical binding]; other site 590998001552 active site 590998001553 UGI interface [polypeptide binding]; other site 590998001554 catalytic site [active] 590998001555 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 590998001556 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 590998001557 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 590998001558 DNA-binding site [nucleotide binding]; DNA binding site 590998001559 RNA-binding motif; other site 590998001560 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 590998001561 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 590998001562 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 590998001563 ring oligomerisation interface [polypeptide binding]; other site 590998001564 ATP/Mg binding site [chemical binding]; other site 590998001565 stacking interactions; other site 590998001566 hinge regions; other site 590998001567 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 590998001568 putative dimer interface [polypeptide binding]; other site 590998001569 catalytic triad [active] 590998001570 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 590998001571 aminotransferase AlaT; Validated; Region: PRK09265 590998001572 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 590998001573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998001574 homodimer interface [polypeptide binding]; other site 590998001575 catalytic residue [active] 590998001576 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 590998001577 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 590998001578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 590998001579 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 590998001580 HAMP domain; Region: HAMP; pfam00672 590998001581 dimerization interface [polypeptide binding]; other site 590998001582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 590998001583 dimer interface [polypeptide binding]; other site 590998001584 phosphorylation site [posttranslational modification] 590998001585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998001586 ATP binding site [chemical binding]; other site 590998001587 Mg2+ binding site [ion binding]; other site 590998001588 G-X-G motif; other site 590998001589 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 590998001590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998001591 active site 590998001592 phosphorylation site [posttranslational modification] 590998001593 intermolecular recognition site; other site 590998001594 dimerization interface [polypeptide binding]; other site 590998001595 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 590998001596 DNA binding site [nucleotide binding] 590998001597 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 590998001598 catalytic triad [active] 590998001599 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 590998001600 Repair protein; Region: Repair_PSII; pfam04536 590998001601 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 590998001602 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 590998001603 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 590998001604 ATP binding site [chemical binding]; other site 590998001605 putative Mg++ binding site [ion binding]; other site 590998001606 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 590998001607 nucleotide binding region [chemical binding]; other site 590998001608 ATP-binding site [chemical binding]; other site 590998001609 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 590998001610 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 590998001611 amidohydrolase; Region: amidohydrolases; TIGR01891 590998001612 metal binding site [ion binding]; metal-binding site 590998001613 dimer interface [polypeptide binding]; other site 590998001614 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 590998001615 DNA-binding site [nucleotide binding]; DNA binding site 590998001616 RNA-binding motif; other site 590998001617 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 590998001618 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 590998001619 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 590998001620 FliW protein; Region: FliW; cl00740 590998001621 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 590998001622 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 590998001623 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 590998001624 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 590998001625 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 590998001626 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 590998001627 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 590998001628 DNA binding residues [nucleotide binding] 590998001629 flagellin; Reviewed; Region: PRK08869 590998001630 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 590998001631 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 590998001632 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 590998001633 Flagellar protein FliS; Region: FliS; cl00654 590998001634 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 590998001635 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 590998001636 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 590998001637 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 590998001638 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 590998001639 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 590998001640 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 590998001641 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 590998001642 FliG C-terminal domain; Region: FliG_C; pfam01706 590998001643 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 590998001644 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 590998001645 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 590998001646 Walker A motif; other site 590998001647 ATP binding site [chemical binding]; other site 590998001648 Walker B motif; other site 590998001649 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 590998001650 NlpC/P60 family; Region: NLPC_P60; pfam00877 590998001651 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 590998001652 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 590998001653 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 590998001654 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 590998001655 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 590998001656 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 590998001657 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998001658 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 590998001659 DNA binding residues [nucleotide binding] 590998001660 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 590998001661 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 590998001662 dimer interface [polypeptide binding]; other site 590998001663 active site 590998001664 metal binding site [ion binding]; metal-binding site 590998001665 Flagellar protein (FlbD); Region: FlbD; pfam06289 590998001666 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 590998001667 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 590998001668 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 590998001669 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 590998001670 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 590998001671 ligand binding site [chemical binding]; other site 590998001672 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 590998001673 Flagellar motor switch protein FliM; Region: FliM; pfam02154 590998001674 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 590998001675 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 590998001676 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 590998001677 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 590998001678 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 590998001679 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 590998001680 FHIPEP family; Region: FHIPEP; pfam00771 590998001681 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 590998001682 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 590998001683 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998001684 putative DNA binding site [nucleotide binding]; other site 590998001685 Transcriptional regulators [Transcription]; Region: MarR; COG1846 590998001686 putative Zn2+ binding site [ion binding]; other site 590998001687 Cation efflux family; Region: Cation_efflux; cl00316 590998001688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998001689 putative substrate translocation pore; other site 590998001690 Major Facilitator Superfamily; Region: MFS_1; pfam07690 590998001691 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 590998001692 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 590998001693 Global regulator protein family; Region: CsrA; pfam02599 590998001694 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 590998001695 putative binding surface; other site 590998001696 active site 590998001697 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 590998001698 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 590998001699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998001700 ATP binding site [chemical binding]; other site 590998001701 Mg2+ binding site [ion binding]; other site 590998001702 G-X-G motif; other site 590998001703 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 590998001704 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 590998001705 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 590998001706 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 590998001707 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 590998001708 dimer interface [polypeptide binding]; other site 590998001709 putative CheW interface [polypeptide binding]; other site 590998001710 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 590998001711 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 590998001712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998001713 active site 590998001714 phosphorylation site [posttranslational modification] 590998001715 intermolecular recognition site; other site 590998001716 dimerization interface [polypeptide binding]; other site 590998001717 CheB methylesterase; Region: CheB_methylest; pfam01339 590998001718 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 590998001719 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 590998001720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998001721 S-adenosylmethionine binding site [chemical binding]; other site 590998001722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998001723 Response regulator receiver domain; Region: Response_reg; pfam00072 590998001724 active site 590998001725 phosphorylation site [posttranslational modification] 590998001726 intermolecular recognition site; other site 590998001727 dimerization interface [polypeptide binding]; other site 590998001728 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 590998001729 Response regulator receiver domain; Region: Response_reg; pfam00072 590998001730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998001731 active site 590998001732 phosphorylation site [posttranslational modification] 590998001733 intermolecular recognition site; other site 590998001734 dimerization interface [polypeptide binding]; other site 590998001735 Low molecular weight phosphatase family; Region: LMWPc; cl00105 590998001736 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 590998001737 active site 590998001738 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 590998001739 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 590998001740 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 590998001741 Chain length determinant protein; Region: Wzz; pfam02706 590998001742 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 590998001743 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 590998001744 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 590998001745 Bacterial sugar transferase; Region: Bac_transf; pfam02397 590998001746 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 590998001747 putative ligand binding site [chemical binding]; other site 590998001748 putative catalytic site [active] 590998001749 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 590998001750 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 590998001751 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 590998001752 active site 590998001753 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 590998001754 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 590998001755 Probable Catalytic site; other site 590998001756 metal-binding site 590998001757 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 590998001758 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 590998001759 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 590998001760 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 590998001761 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 590998001762 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 590998001763 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 590998001764 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 590998001765 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 590998001766 MarR family; Region: MarR; pfam01047 590998001767 H+ Antiporter protein; Region: 2A0121; TIGR00900 590998001768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998001769 putative substrate translocation pore; other site 590998001770 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 590998001771 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 590998001772 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 590998001773 catalytic residue [active] 590998001774 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 590998001775 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 590998001776 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 590998001777 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 590998001778 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 590998001779 NlpC/P60 family; Region: NLPC_P60; pfam00877 590998001780 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 590998001781 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 590998001782 active site 590998001783 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 590998001784 Ligand Binding Site [chemical binding]; other site 590998001785 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 590998001786 Ligand Binding Site [chemical binding]; other site 590998001787 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 590998001788 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 590998001789 AsnC family; Region: AsnC_trans_reg; pfam01037 590998001790 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 590998001791 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 590998001792 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 590998001793 inhibitor-cofactor binding pocket; inhibition site 590998001794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998001795 catalytic residue [active] 590998001796 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 590998001797 Amidinotransferase; Region: Amidinotransf; pfam02274 590998001798 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 590998001799 hydrophobic ligand binding site; other site 590998001800 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 590998001801 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 590998001802 active site 590998001803 catalytic tetrad [active] 590998001804 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 590998001805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998001806 putative substrate translocation pore; other site 590998001807 Major Facilitator Superfamily; Region: MFS_1; pfam07690 590998001808 Methyltransferase domain; Region: Methyltransf_26; pfam13659 590998001809 SWIM zinc finger; Region: SWIM; pfam04434 590998001810 MoxR-like ATPases [General function prediction only]; Region: COG0714 590998001811 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 590998001812 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 590998001813 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 590998001814 metal ion-dependent adhesion site (MIDAS); other site 590998001815 Pleckstrin homology-like domain; Region: PH-like; cl17171 590998001816 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 590998001817 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 590998001818 von Willebrand factor; Region: vWF_A; pfam12450 590998001819 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 590998001820 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 590998001821 metal ion-dependent adhesion site (MIDAS); other site 590998001822 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 590998001823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998001824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998001825 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 590998001826 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 590998001827 putative NAD(P) binding site [chemical binding]; other site 590998001828 Domain of unknown function (DUF385); Region: DUF385; cl04387 590998001829 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 590998001830 MarR family; Region: MarR; pfam01047 590998001831 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 590998001832 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 590998001833 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 590998001834 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 590998001835 active site 590998001836 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 590998001837 Beta-lactamase; Region: Beta-lactamase; pfam00144 590998001838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998001839 S-adenosylmethionine binding site [chemical binding]; other site 590998001840 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 590998001841 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 590998001842 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 590998001843 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998001844 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 590998001845 DNA binding residues [nucleotide binding] 590998001846 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 590998001847 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 590998001848 dimer interface [polypeptide binding]; other site 590998001849 putative CheW interface [polypeptide binding]; other site 590998001850 PAS fold; Region: PAS_2; pfam08446 590998001851 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 590998001852 GAF domain; Region: GAF; pfam01590 590998001853 Phytochrome region; Region: PHY; pfam00360 590998001854 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 590998001855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 590998001856 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 590998001857 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 590998001858 FAD binding pocket [chemical binding]; other site 590998001859 FAD binding motif [chemical binding]; other site 590998001860 phosphate binding motif [ion binding]; other site 590998001861 NAD binding pocket [chemical binding]; other site 590998001862 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 590998001863 Trehalase; Region: Trehalase; cl17346 590998001864 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 590998001865 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 590998001866 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 590998001867 substrate binding site [chemical binding]; other site 590998001868 active site 590998001869 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 590998001870 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 590998001871 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 590998001872 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 590998001873 ligand binding site [chemical binding]; other site 590998001874 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 590998001875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998001876 active site 590998001877 phosphorylation site [posttranslational modification] 590998001878 intermolecular recognition site; other site 590998001879 dimerization interface [polypeptide binding]; other site 590998001880 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 590998001881 DNA binding site [nucleotide binding] 590998001882 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 590998001883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998001884 ATP binding site [chemical binding]; other site 590998001885 Mg2+ binding site [ion binding]; other site 590998001886 G-X-G motif; other site 590998001887 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998001888 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998001889 DNA binding site [nucleotide binding] 590998001890 domain linker motif; other site 590998001891 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998001892 dimerization interface [polypeptide binding]; other site 590998001893 ligand binding site [chemical binding]; other site 590998001894 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 590998001895 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 590998001896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998001897 ABC-ATPase subunit interface; other site 590998001898 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998001899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998001900 dimer interface [polypeptide binding]; other site 590998001901 conserved gate region; other site 590998001902 putative PBP binding loops; other site 590998001903 ABC-ATPase subunit interface; other site 590998001904 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 590998001905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 590998001906 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 590998001907 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 590998001908 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 590998001909 active site 590998001910 DNA binding site [nucleotide binding] 590998001911 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 590998001912 DNA binding site [nucleotide binding] 590998001913 FOG: CBS domain [General function prediction only]; Region: COG0517 590998001914 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 590998001915 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 590998001916 Isochorismatase family; Region: Isochorismatase; pfam00857 590998001917 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 590998001918 catalytic triad [active] 590998001919 conserved cis-peptide bond; other site 590998001920 YCII-related domain; Region: YCII; cl00999 590998001921 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 590998001922 Amb_all domain; Region: Amb_all; smart00656 590998001923 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 590998001924 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 590998001925 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 590998001926 nudix motif; other site 590998001927 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 590998001928 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 590998001929 active site 590998001930 catalytic tetrad [active] 590998001931 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 590998001932 substrate binding site [chemical binding]; other site 590998001933 classical (c) SDRs; Region: SDR_c; cd05233 590998001934 active site 590998001935 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 590998001936 putative DNA binding site [nucleotide binding]; other site 590998001937 putative Zn2+ binding site [ion binding]; other site 590998001938 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 590998001939 Domain of unknown function (DUF385); Region: DUF385; cl04387 590998001940 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 590998001941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998001942 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998001943 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 590998001944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998001945 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 590998001946 Walker A/P-loop; other site 590998001947 ATP binding site [chemical binding]; other site 590998001948 Q-loop/lid; other site 590998001949 ABC transporter signature motif; other site 590998001950 Walker B; other site 590998001951 D-loop; other site 590998001952 H-loop/switch region; other site 590998001953 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 590998001954 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 590998001955 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 590998001956 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 590998001957 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 590998001958 Response regulator receiver domain; Region: Response_reg; pfam00072 590998001959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998001960 active site 590998001961 phosphorylation site [posttranslational modification] 590998001962 intermolecular recognition site; other site 590998001963 dimerization interface [polypeptide binding]; other site 590998001964 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 590998001965 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 590998001966 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 590998001967 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 590998001968 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 590998001969 active site 590998001970 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 590998001971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998001972 Response regulator receiver domain; Region: Response_reg; pfam00072 590998001973 active site 590998001974 phosphorylation site [posttranslational modification] 590998001975 intermolecular recognition site; other site 590998001976 dimerization interface [polypeptide binding]; other site 590998001977 PAS domain; Region: PAS_9; pfam13426 590998001978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 590998001979 putative active site [active] 590998001980 heme pocket [chemical binding]; other site 590998001981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 590998001982 dimer interface [polypeptide binding]; other site 590998001983 phosphorylation site [posttranslational modification] 590998001984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998001985 ATP binding site [chemical binding]; other site 590998001986 Mg2+ binding site [ion binding]; other site 590998001987 G-X-G motif; other site 590998001988 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 590998001989 FAD binding domain; Region: FAD_binding_4; pfam01565 590998001990 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 590998001991 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 590998001992 metal binding site [ion binding]; metal-binding site 590998001993 active site 590998001994 I-site; other site 590998001995 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 590998001996 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 590998001997 Catalytic site [active] 590998001998 methionine sulfoxide reductase B; Provisional; Region: PRK00222 590998001999 SelR domain; Region: SelR; pfam01641 590998002000 Transcriptional regulators [Transcription]; Region: MarR; COG1846 590998002001 MarR family; Region: MarR; pfam01047 590998002002 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 590998002003 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 590998002004 Malic enzyme, N-terminal domain; Region: malic; pfam00390 590998002005 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 590998002006 NAD(P) binding pocket [chemical binding]; other site 590998002007 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 590998002008 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 590998002009 motif II; other site 590998002010 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 590998002011 Type II/IV secretion system protein; Region: T2SE; pfam00437 590998002012 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 590998002013 ATP binding site [chemical binding]; other site 590998002014 Walker A motif; other site 590998002015 hexamer interface [polypeptide binding]; other site 590998002016 Walker B motif; other site 590998002017 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 590998002018 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 590998002019 ATP binding site [chemical binding]; other site 590998002020 putative Mg++ binding site [ion binding]; other site 590998002021 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 590998002022 helicase superfamily c-terminal domain; Region: HELICc; smart00490 590998002023 nucleotide binding region [chemical binding]; other site 590998002024 ATP-binding site [chemical binding]; other site 590998002025 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 590998002026 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 590998002027 putative active site [active] 590998002028 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 590998002029 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 590998002030 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 590998002031 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 590998002032 Class III ribonucleotide reductase; Region: RNR_III; cd01675 590998002033 effector binding site; other site 590998002034 active site 590998002035 Zn binding site [ion binding]; other site 590998002036 glycine loop; other site 590998002037 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 590998002038 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 590998002039 FeS/SAM binding site; other site 590998002040 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 590998002041 anti sigma factor interaction site; other site 590998002042 regulatory phosphorylation site [posttranslational modification]; other site 590998002043 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 590998002044 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 590998002045 DNA binding residues [nucleotide binding] 590998002046 HTH domain; Region: HTH_11; pfam08279 590998002047 WYL domain; Region: WYL; pfam13280 590998002048 Epoxide hydrolase N terminus; Region: EHN; pfam06441 590998002049 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 590998002050 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 590998002051 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 590998002052 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 590998002053 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 590998002054 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998002055 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998002056 dimerization interface [polypeptide binding]; other site 590998002057 ligand binding site [chemical binding]; other site 590998002058 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 590998002059 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 590998002060 putative ligand binding site [chemical binding]; other site 590998002061 putative NAD binding site [chemical binding]; other site 590998002062 catalytic site [active] 590998002063 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 590998002064 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 590998002065 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 590998002066 putative metal binding site [ion binding]; other site 590998002067 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 590998002068 putative catalytic site [active] 590998002069 putative phosphate binding site [ion binding]; other site 590998002070 putative metal binding site [ion binding]; other site 590998002071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998002072 S-adenosylmethionine binding site [chemical binding]; other site 590998002073 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 590998002074 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 590998002075 S-layer homology domain; Region: SLH; pfam00395 590998002076 S-layer homology domain; Region: SLH; pfam00395 590998002077 S-layer homology domain; Region: SLH; pfam00395 590998002078 HlyD family secretion protein; Region: HlyD_3; pfam13437 590998002079 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 590998002080 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 590998002081 Walker A/P-loop; other site 590998002082 ATP binding site [chemical binding]; other site 590998002083 Q-loop/lid; other site 590998002084 ABC transporter signature motif; other site 590998002085 Walker B; other site 590998002086 D-loop; other site 590998002087 H-loop/switch region; other site 590998002088 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 590998002089 FtsX-like permease family; Region: FtsX; pfam02687 590998002090 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 590998002091 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 590998002092 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998002093 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998002094 DNA binding site [nucleotide binding] 590998002095 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 590998002096 dimerization interface (open form) [polypeptide binding]; other site 590998002097 ligand binding site [chemical binding]; other site 590998002098 dimerization interface (closed form) [polypeptide binding]; other site 590998002099 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 590998002100 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 590998002101 putative N- and C-terminal domain interface [polypeptide binding]; other site 590998002102 putative active site [active] 590998002103 MgATP binding site [chemical binding]; other site 590998002104 catalytic site [active] 590998002105 metal binding site [ion binding]; metal-binding site 590998002106 putative carbohydrate binding site [chemical binding]; other site 590998002107 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 590998002108 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 590998002109 intersubunit interface [polypeptide binding]; other site 590998002110 active site 590998002111 Zn2+ binding site [ion binding]; other site 590998002112 L-arabinose isomerase; Provisional; Region: PRK02929 590998002113 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 590998002114 hexamer (dimer of trimers) interface [polypeptide binding]; other site 590998002115 trimer interface [polypeptide binding]; other site 590998002116 substrate binding site [chemical binding]; other site 590998002117 Mn binding site [ion binding]; other site 590998002118 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 590998002119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998002120 Coenzyme A binding pocket [chemical binding]; other site 590998002121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 590998002122 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 590998002123 Predicted membrane protein [Function unknown]; Region: COG4270 590998002124 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 590998002125 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 590998002126 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 590998002127 Walker A/P-loop; other site 590998002128 ATP binding site [chemical binding]; other site 590998002129 Q-loop/lid; other site 590998002130 ABC transporter signature motif; other site 590998002131 Walker B; other site 590998002132 D-loop; other site 590998002133 H-loop/switch region; other site 590998002134 ABC-2 type transporter; Region: ABC2_membrane; cl17235 590998002135 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 590998002136 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998002137 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998002138 DNA binding site [nucleotide binding] 590998002139 domain linker motif; other site 590998002140 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 590998002141 ligand binding site [chemical binding]; other site 590998002142 dimerization interface (open form) [polypeptide binding]; other site 590998002143 dimerization interface (closed form) [polypeptide binding]; other site 590998002144 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998002145 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 590998002146 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 590998002147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998002148 dimer interface [polypeptide binding]; other site 590998002149 conserved gate region; other site 590998002150 putative PBP binding loops; other site 590998002151 ABC-ATPase subunit interface; other site 590998002152 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998002153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998002154 dimer interface [polypeptide binding]; other site 590998002155 conserved gate region; other site 590998002156 putative PBP binding loops; other site 590998002157 ABC-ATPase subunit interface; other site 590998002158 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 590998002159 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 590998002160 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 590998002161 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 590998002162 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 590998002163 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 590998002164 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 590998002165 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 590998002166 putative ligand binding site [chemical binding]; other site 590998002167 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 590998002168 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 590998002169 Walker A/P-loop; other site 590998002170 ATP binding site [chemical binding]; other site 590998002171 Q-loop/lid; other site 590998002172 ABC transporter signature motif; other site 590998002173 Walker B; other site 590998002174 D-loop; other site 590998002175 H-loop/switch region; other site 590998002176 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 590998002177 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 590998002178 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 590998002179 TM-ABC transporter signature motif; other site 590998002180 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 590998002181 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 590998002182 TM-ABC transporter signature motif; other site 590998002183 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 590998002184 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 590998002185 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 590998002186 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 590998002187 active site 590998002188 Zn binding site [ion binding]; other site 590998002189 DNA binding domain, excisionase family; Region: excise; TIGR01764 590998002190 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998002191 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998002192 DNA binding site [nucleotide binding] 590998002193 domain linker motif; other site 590998002194 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998002195 dimerization interface [polypeptide binding]; other site 590998002196 ligand binding site [chemical binding]; other site 590998002197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 590998002198 non-specific DNA binding site [nucleotide binding]; other site 590998002199 salt bridge; other site 590998002200 sequence-specific DNA binding site [nucleotide binding]; other site 590998002201 HipA N-terminal domain; Region: Couple_hipA; pfam13657 590998002202 HipA-like N-terminal domain; Region: HipA_N; pfam07805 590998002203 HipA-like C-terminal domain; Region: HipA_C; pfam07804 590998002204 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 590998002205 substrate binding site [chemical binding]; other site 590998002206 active site 590998002207 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998002208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998002209 dimer interface [polypeptide binding]; other site 590998002210 conserved gate region; other site 590998002211 putative PBP binding loops; other site 590998002212 ABC-ATPase subunit interface; other site 590998002213 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 590998002214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998002215 ABC-ATPase subunit interface; other site 590998002216 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998002217 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 590998002218 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 590998002219 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 590998002220 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 590998002221 substrate binding site [chemical binding]; other site 590998002222 active site 590998002223 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 590998002224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998002225 Coenzyme A binding pocket [chemical binding]; other site 590998002226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 590998002227 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 590998002228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 590998002229 motif II; other site 590998002230 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 590998002231 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 590998002232 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 590998002233 CoA binding domain; Region: CoA_binding; smart00881 590998002234 Uncharacterized conserved protein [Function unknown]; Region: COG2353 590998002235 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 590998002236 MarR family; Region: MarR_2; pfam12802 590998002237 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 590998002238 catalytic core [active] 590998002239 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 590998002240 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 590998002241 catalytic residues [active] 590998002242 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 590998002243 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 590998002244 ResB-like family; Region: ResB; pfam05140 590998002245 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 590998002246 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 590998002247 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 590998002248 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 590998002249 UbiA prenyltransferase family; Region: UbiA; pfam01040 590998002250 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 590998002251 AMP binding site [chemical binding]; other site 590998002252 active site 590998002253 acyl-activating enzyme (AAE) consensus motif; other site 590998002254 CoA binding site [chemical binding]; other site 590998002255 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 590998002256 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 590998002257 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 590998002258 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 590998002259 substrate binding site [chemical binding]; other site 590998002260 oxyanion hole (OAH) forming residues; other site 590998002261 trimer interface [polypeptide binding]; other site 590998002262 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 590998002263 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 590998002264 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 590998002265 active site 590998002266 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 590998002267 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 590998002268 dimer interface [polypeptide binding]; other site 590998002269 tetramer interface [polypeptide binding]; other site 590998002270 PYR/PP interface [polypeptide binding]; other site 590998002271 TPP binding site [chemical binding]; other site 590998002272 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 590998002273 TPP-binding site; other site 590998002274 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 590998002275 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 590998002276 protein binding site [polypeptide binding]; other site 590998002277 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 590998002278 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 590998002279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998002280 S-adenosylmethionine binding site [chemical binding]; other site 590998002281 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 590998002282 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 590998002283 NADH dehydrogenase subunit B; Validated; Region: PRK06411 590998002284 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 590998002285 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 590998002286 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 590998002287 NADH dehydrogenase subunit D; Validated; Region: PRK06075 590998002288 NADH dehydrogenase subunit E; Validated; Region: PRK07539 590998002289 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 590998002290 putative dimer interface [polypeptide binding]; other site 590998002291 [2Fe-2S] cluster binding site [ion binding]; other site 590998002292 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 590998002293 SLBB domain; Region: SLBB; pfam10531 590998002294 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 590998002295 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 590998002296 NADH dehydrogenase subunit G; Validated; Region: PRK07860 590998002297 catalytic loop [active] 590998002298 iron binding site [ion binding]; other site 590998002299 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 590998002300 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 590998002301 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 590998002302 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 590998002303 molybdopterin cofactor binding site; other site 590998002304 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 590998002305 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 590998002306 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 590998002307 4Fe-4S binding domain; Region: Fer4; pfam00037 590998002308 4Fe-4S binding domain; Region: Fer4; pfam00037 590998002309 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 590998002310 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 590998002311 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 590998002312 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 590998002313 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 590998002314 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 590998002315 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 590998002316 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 590998002317 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 590998002318 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 590998002319 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 590998002320 substrate binding pocket [chemical binding]; other site 590998002321 chain length determination region; other site 590998002322 substrate-Mg2+ binding site; other site 590998002323 catalytic residues [active] 590998002324 aspartate-rich region 1; other site 590998002325 active site lid residues [active] 590998002326 aspartate-rich region 2; other site 590998002327 RDD family; Region: RDD; pfam06271 590998002328 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 590998002329 phosphopeptide binding site; other site 590998002330 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 590998002331 active site 590998002332 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 590998002333 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 590998002334 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 590998002335 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 590998002336 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 590998002337 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 590998002338 active site 590998002339 catalytic residues [active] 590998002340 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 590998002341 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 590998002342 Double zinc ribbon; Region: DZR; pfam12773 590998002343 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 590998002344 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 590998002345 phosphopeptide binding site; other site 590998002346 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 590998002347 Protein of unknown function (DUF690); Region: DUF690; cl04939 590998002348 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 590998002349 active site 590998002350 catalytic residues [active] 590998002351 Predicted permeases [General function prediction only]; Region: RarD; COG2962 590998002352 ferredoxin-NADP+ reductase; Region: PLN02852 590998002353 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 590998002354 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 590998002355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998002356 Walker A/P-loop; other site 590998002357 ATP binding site [chemical binding]; other site 590998002358 Q-loop/lid; other site 590998002359 ABC transporter signature motif; other site 590998002360 Walker B; other site 590998002361 D-loop; other site 590998002362 H-loop/switch region; other site 590998002363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998002364 ABC-ATPase subunit interface; other site 590998002365 putative PBP binding loops; other site 590998002366 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 590998002367 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 590998002368 substrate binding pocket [chemical binding]; other site 590998002369 membrane-bound complex binding site; other site 590998002370 hinge residues; other site 590998002371 heat shock protein HtpX; Provisional; Region: PRK03072 590998002372 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 590998002373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 590998002374 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 590998002375 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 590998002376 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 590998002377 active site 590998002378 catalytic site [active] 590998002379 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 590998002380 active site 2 [active] 590998002381 active site 1 [active] 590998002382 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998002383 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998002384 DNA binding site [nucleotide binding] 590998002385 domain linker motif; other site 590998002386 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 590998002387 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 590998002388 FAD binding domain; Region: FAD_binding_4; pfam01565 590998002389 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 590998002390 adenosine deaminase; Provisional; Region: PRK09358 590998002391 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 590998002392 active site 590998002393 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 590998002394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998002395 active site 590998002396 phosphorylation site [posttranslational modification] 590998002397 intermolecular recognition site; other site 590998002398 dimerization interface [polypeptide binding]; other site 590998002399 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 590998002400 DNA binding site [nucleotide binding] 590998002401 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 590998002402 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 590998002403 dimerization interface [polypeptide binding]; other site 590998002404 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 590998002405 dimer interface [polypeptide binding]; other site 590998002406 phosphorylation site [posttranslational modification] 590998002407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998002408 ATP binding site [chemical binding]; other site 590998002409 Mg2+ binding site [ion binding]; other site 590998002410 G-X-G motif; other site 590998002411 aspartate aminotransferase; Provisional; Region: PRK05764 590998002412 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 590998002413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998002414 homodimer interface [polypeptide binding]; other site 590998002415 catalytic residue [active] 590998002416 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 590998002417 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 590998002418 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 590998002419 putative homodimer interface [polypeptide binding]; other site 590998002420 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 590998002421 heterodimer interface [polypeptide binding]; other site 590998002422 homodimer interface [polypeptide binding]; other site 590998002423 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 590998002424 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 590998002425 23S rRNA interface [nucleotide binding]; other site 590998002426 L7/L12 interface [polypeptide binding]; other site 590998002427 putative thiostrepton binding site; other site 590998002428 L25 interface [polypeptide binding]; other site 590998002429 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 590998002430 mRNA/rRNA interface [nucleotide binding]; other site 590998002431 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 590998002432 CHAT domain; Region: CHAT; pfam12770 590998002433 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 590998002434 23S rRNA interface [nucleotide binding]; other site 590998002435 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 590998002436 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 590998002437 L11 interface [polypeptide binding]; other site 590998002438 putative EF-Tu interaction site [polypeptide binding]; other site 590998002439 putative EF-G interaction site [polypeptide binding]; other site 590998002440 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 590998002441 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 590998002442 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 590998002443 RPB1 interaction site [polypeptide binding]; other site 590998002444 RPB10 interaction site [polypeptide binding]; other site 590998002445 RPB11 interaction site [polypeptide binding]; other site 590998002446 RPB3 interaction site [polypeptide binding]; other site 590998002447 RPB12 interaction site [polypeptide binding]; other site 590998002448 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 590998002449 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 590998002450 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 590998002451 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 590998002452 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 590998002453 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 590998002454 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 590998002455 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 590998002456 G-loop; other site 590998002457 DNA binding site [nucleotide binding] 590998002458 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 590998002459 S17 interaction site [polypeptide binding]; other site 590998002460 S8 interaction site; other site 590998002461 16S rRNA interaction site [nucleotide binding]; other site 590998002462 streptomycin interaction site [chemical binding]; other site 590998002463 23S rRNA interaction site [nucleotide binding]; other site 590998002464 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 590998002465 30S ribosomal protein S7; Validated; Region: PRK05302 590998002466 elongation factor G; Reviewed; Region: PRK00007 590998002467 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 590998002468 G1 box; other site 590998002469 putative GEF interaction site [polypeptide binding]; other site 590998002470 GTP/Mg2+ binding site [chemical binding]; other site 590998002471 Switch I region; other site 590998002472 G2 box; other site 590998002473 G3 box; other site 590998002474 Switch II region; other site 590998002475 G4 box; other site 590998002476 G5 box; other site 590998002477 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 590998002478 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 590998002479 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 590998002480 elongation factor Tu; Reviewed; Region: PRK00049 590998002481 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 590998002482 G1 box; other site 590998002483 GEF interaction site [polypeptide binding]; other site 590998002484 GTP/Mg2+ binding site [chemical binding]; other site 590998002485 Switch I region; other site 590998002486 G2 box; other site 590998002487 G3 box; other site 590998002488 Switch II region; other site 590998002489 G4 box; other site 590998002490 G5 box; other site 590998002491 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 590998002492 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 590998002493 Antibiotic Binding Site [chemical binding]; other site 590998002494 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 590998002495 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 590998002496 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 590998002497 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 590998002498 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 590998002499 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 590998002500 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 590998002501 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 590998002502 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 590998002503 putative translocon binding site; other site 590998002504 protein-rRNA interface [nucleotide binding]; other site 590998002505 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 590998002506 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 590998002507 G-X-X-G motif; other site 590998002508 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 590998002509 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 590998002510 23S rRNA interface [nucleotide binding]; other site 590998002511 5S rRNA interface [nucleotide binding]; other site 590998002512 putative antibiotic binding site [chemical binding]; other site 590998002513 L25 interface [polypeptide binding]; other site 590998002514 L27 interface [polypeptide binding]; other site 590998002515 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 590998002516 L23 interface [polypeptide binding]; other site 590998002517 signal recognition particle (SRP54) interaction site; other site 590998002518 trigger factor interaction site; other site 590998002519 23S rRNA interface [nucleotide binding]; other site 590998002520 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 590998002521 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 590998002522 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 590998002523 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 590998002524 RNA binding site [nucleotide binding]; other site 590998002525 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 590998002526 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 590998002527 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 590998002528 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 590998002529 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 590998002530 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 590998002531 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 590998002532 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 590998002533 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 590998002534 5S rRNA interface [nucleotide binding]; other site 590998002535 L27 interface [polypeptide binding]; other site 590998002536 23S rRNA interface [nucleotide binding]; other site 590998002537 L5 interface [polypeptide binding]; other site 590998002538 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 590998002539 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 590998002540 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 590998002541 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 590998002542 23S rRNA binding site [nucleotide binding]; other site 590998002543 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 590998002544 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 590998002545 SecY translocase; Region: SecY; pfam00344 590998002546 adenylate kinase; Reviewed; Region: adk; PRK00279 590998002547 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 590998002548 AMP-binding site [chemical binding]; other site 590998002549 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 590998002550 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 590998002551 active site 590998002552 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 590998002553 rRNA binding site [nucleotide binding]; other site 590998002554 predicted 30S ribosome binding site; other site 590998002555 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 590998002556 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 590998002557 30S ribosomal protein S13; Region: bact_S13; TIGR03631 590998002558 30S ribosomal protein S11; Validated; Region: PRK05309 590998002559 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 590998002560 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 590998002561 alphaNTD - beta interaction site [polypeptide binding]; other site 590998002562 alphaNTD homodimer interface [polypeptide binding]; other site 590998002563 alphaNTD - beta' interaction site [polypeptide binding]; other site 590998002564 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 590998002565 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 590998002566 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 590998002567 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 590998002568 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 590998002569 nucleotide binding site [chemical binding]; other site 590998002570 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 590998002571 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 590998002572 dimerization interface 3.5A [polypeptide binding]; other site 590998002573 active site 590998002574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998002575 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 590998002576 Walker A/P-loop; other site 590998002577 ATP binding site [chemical binding]; other site 590998002578 Q-loop/lid; other site 590998002579 ABC transporter signature motif; other site 590998002580 Walker B; other site 590998002581 D-loop; other site 590998002582 H-loop/switch region; other site 590998002583 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 590998002584 LysE type translocator; Region: LysE; cl00565 590998002585 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 590998002586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 590998002587 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 590998002588 dimerization interface [polypeptide binding]; other site 590998002589 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 590998002590 23S rRNA interface [nucleotide binding]; other site 590998002591 L3 interface [polypeptide binding]; other site 590998002592 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 590998002593 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 590998002594 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 590998002595 active site 590998002596 substrate binding site [chemical binding]; other site 590998002597 metal binding site [ion binding]; metal-binding site 590998002598 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 590998002599 active site 590998002600 catalytic residues [active] 590998002601 metal binding site [ion binding]; metal-binding site 590998002602 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 590998002603 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 590998002604 pantothenate kinase; Provisional; Region: PRK05439 590998002605 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 590998002606 ATP-binding site [chemical binding]; other site 590998002607 CoA-binding site [chemical binding]; other site 590998002608 Mg2+-binding site [ion binding]; other site 590998002609 CHASE3 domain; Region: CHASE3; pfam05227 590998002610 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 590998002611 dimerization interface [polypeptide binding]; other site 590998002612 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 590998002613 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 590998002614 dimer interface [polypeptide binding]; other site 590998002615 putative CheW interface [polypeptide binding]; other site 590998002616 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 590998002617 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 590998002618 glutaminase active site [active] 590998002619 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 590998002620 dimer interface [polypeptide binding]; other site 590998002621 active site 590998002622 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 590998002623 dimer interface [polypeptide binding]; other site 590998002624 active site 590998002625 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 590998002626 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 590998002627 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 590998002628 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 590998002629 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 590998002630 ATP binding site [chemical binding]; other site 590998002631 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 590998002632 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 590998002633 active site 590998002634 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 590998002635 alanine racemase; Reviewed; Region: alr; PRK00053 590998002636 active site 590998002637 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 590998002638 dimer interface [polypeptide binding]; other site 590998002639 substrate binding site [chemical binding]; other site 590998002640 catalytic residues [active] 590998002641 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 590998002642 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 590998002643 Glycoprotease family; Region: Peptidase_M22; pfam00814 590998002644 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 590998002645 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 590998002646 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 590998002647 active site residue [active] 590998002648 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 590998002649 active site residue [active] 590998002650 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 590998002651 FMN binding site [chemical binding]; other site 590998002652 dimer interface [polypeptide binding]; other site 590998002653 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 590998002654 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 590998002655 Predicted transcriptional regulators [Transcription]; Region: COG1695 590998002656 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 590998002657 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 590998002658 active site 590998002659 metal binding site [ion binding]; metal-binding site 590998002660 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 590998002661 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 590998002662 Helix-turn-helix domain; Region: HTH_38; pfam13936 590998002663 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998002664 dimerization interface [polypeptide binding]; other site 590998002665 putative Zn2+ binding site [ion binding]; other site 590998002666 putative DNA binding site [nucleotide binding]; other site 590998002667 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 590998002668 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 590998002669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998002670 Walker A/P-loop; other site 590998002671 ATP binding site [chemical binding]; other site 590998002672 Q-loop/lid; other site 590998002673 ABC transporter signature motif; other site 590998002674 Walker B; other site 590998002675 D-loop; other site 590998002676 H-loop/switch region; other site 590998002677 ABC-2 type transporter; Region: ABC2_membrane; cl17235 590998002678 carboxylate-amine ligase; Provisional; Region: PRK13517 590998002679 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 590998002680 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 590998002681 oligomerisation interface [polypeptide binding]; other site 590998002682 mobile loop; other site 590998002683 roof hairpin; other site 590998002684 Transcription factor WhiB; Region: Whib; pfam02467 590998002685 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 590998002686 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 590998002687 DNA binding residues [nucleotide binding] 590998002688 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 590998002689 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 590998002690 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 590998002691 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 590998002692 active site 590998002693 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 590998002694 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 590998002695 active site 590998002696 catalytic site [active] 590998002697 substrate binding site [chemical binding]; other site 590998002698 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 590998002699 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 590998002700 active site 590998002701 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 590998002702 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 590998002703 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 590998002704 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 590998002705 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 590998002706 putative substrate binding site [chemical binding]; other site 590998002707 putative ATP binding site [chemical binding]; other site 590998002708 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 590998002709 active site 590998002710 phosphorylation site [posttranslational modification] 590998002711 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 590998002712 active site 590998002713 P-loop; other site 590998002714 phosphorylation site [posttranslational modification] 590998002715 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 590998002716 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 590998002717 dimerization domain swap beta strand [polypeptide binding]; other site 590998002718 regulatory protein interface [polypeptide binding]; other site 590998002719 active site 590998002720 regulatory phosphorylation site [posttranslational modification]; other site 590998002721 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 590998002722 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 590998002723 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 590998002724 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 590998002725 aminoglycoside resistance protein; Provisional; Region: PRK13746 590998002726 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 590998002727 active site 590998002728 NTP binding site [chemical binding]; other site 590998002729 metal binding triad [ion binding]; metal-binding site 590998002730 antibiotic binding site [chemical binding]; other site 590998002731 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 590998002732 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 590998002733 NAD(P) binding site [chemical binding]; other site 590998002734 catalytic residues [active] 590998002735 propionate/acetate kinase; Provisional; Region: PRK12379 590998002736 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 590998002737 phosphate acetyltransferase; Reviewed; Region: PRK05632 590998002738 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 590998002739 DRTGG domain; Region: DRTGG; pfam07085 590998002740 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 590998002741 putative phosphoketolase; Provisional; Region: PRK05261 590998002742 XFP N-terminal domain; Region: XFP_N; pfam09364 590998002743 Src Homology 3 domain superfamily; Region: SH3; cl17036 590998002744 peptide ligand binding site [polypeptide binding]; other site 590998002745 XFP C-terminal domain; Region: XFP_C; pfam09363 590998002746 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 590998002747 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 590998002748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998002749 Walker A/P-loop; other site 590998002750 ATP binding site [chemical binding]; other site 590998002751 Q-loop/lid; other site 590998002752 ABC transporter signature motif; other site 590998002753 Walker B; other site 590998002754 D-loop; other site 590998002755 H-loop/switch region; other site 590998002756 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 590998002757 Histidine kinase; Region: HisKA_3; pfam07730 590998002758 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998002759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998002760 active site 590998002761 phosphorylation site [posttranslational modification] 590998002762 intermolecular recognition site; other site 590998002763 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998002764 DNA binding residues [nucleotide binding] 590998002765 hypothetical protein; Provisional; Region: PRK09256 590998002766 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 590998002767 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 590998002768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998002769 Walker A/P-loop; other site 590998002770 ATP binding site [chemical binding]; other site 590998002771 Q-loop/lid; other site 590998002772 ABC transporter signature motif; other site 590998002773 Walker B; other site 590998002774 D-loop; other site 590998002775 H-loop/switch region; other site 590998002776 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 590998002777 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 590998002778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998002779 Q-loop/lid; other site 590998002780 ABC transporter signature motif; other site 590998002781 Walker B; other site 590998002782 D-loop; other site 590998002783 H-loop/switch region; other site 590998002784 GMP synthase; Reviewed; Region: guaA; PRK00074 590998002785 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 590998002786 AMP/PPi binding site [chemical binding]; other site 590998002787 candidate oxyanion hole; other site 590998002788 catalytic triad [active] 590998002789 potential glutamine specificity residues [chemical binding]; other site 590998002790 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 590998002791 ATP Binding subdomain [chemical binding]; other site 590998002792 Ligand Binding sites [chemical binding]; other site 590998002793 Dimerization subdomain; other site 590998002794 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 590998002795 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 590998002796 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 590998002797 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 590998002798 PspC domain; Region: PspC; pfam04024 590998002799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 590998002800 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998002801 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998002802 DNA binding residues [nucleotide binding] 590998002803 dimerization interface [polypeptide binding]; other site 590998002804 Protein of unknown function (DUF456); Region: DUF456; cl01069 590998002805 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 590998002806 Part of AAA domain; Region: AAA_19; pfam13245 590998002807 Family description; Region: UvrD_C_2; pfam13538 590998002808 Clp amino terminal domain; Region: Clp_N; pfam02861 590998002809 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 590998002810 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 590998002811 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 590998002812 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 590998002813 ligand binding site [chemical binding]; other site 590998002814 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 590998002815 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 590998002816 CoA-ligase; Region: Ligase_CoA; pfam00549 590998002817 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 590998002818 CoA binding domain; Region: CoA_binding; smart00881 590998002819 CoA-ligase; Region: Ligase_CoA; pfam00549 590998002820 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 590998002821 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 590998002822 active site 590998002823 substrate binding site [chemical binding]; other site 590998002824 cosubstrate binding site; other site 590998002825 catalytic site [active] 590998002826 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 590998002827 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 590998002828 purine monophosphate binding site [chemical binding]; other site 590998002829 dimer interface [polypeptide binding]; other site 590998002830 putative catalytic residues [active] 590998002831 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 590998002832 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 590998002833 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 590998002834 amphipathic channel; other site 590998002835 Asn-Pro-Ala signature motifs; other site 590998002836 isocitrate dehydrogenase; Validated; Region: PRK08299 590998002837 malate dehydrogenase; Provisional; Region: PRK05442 590998002838 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 590998002839 NAD(P) binding site [chemical binding]; other site 590998002840 dimer interface [polypeptide binding]; other site 590998002841 malate binding site [chemical binding]; other site 590998002842 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 590998002843 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 590998002844 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 590998002845 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 590998002846 active site 590998002847 catalytic site [active] 590998002848 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 590998002849 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 590998002850 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 590998002851 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 590998002852 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 590998002853 Ca binding site [ion binding]; other site 590998002854 active site 590998002855 catalytic site [active] 590998002856 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 590998002857 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 590998002858 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 590998002859 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 590998002860 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 590998002861 putative active site [active] 590998002862 putative substrate binding site [chemical binding]; other site 590998002863 putative cosubstrate binding site; other site 590998002864 catalytic site [active] 590998002865 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 590998002866 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998002867 Coenzyme A binding pocket [chemical binding]; other site 590998002868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 590998002869 Phosphotransferase enzyme family; Region: APH; pfam01636 590998002870 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 590998002871 active site 590998002872 ATP binding site [chemical binding]; other site 590998002873 EamA-like transporter family; Region: EamA; pfam00892 590998002874 EamA-like transporter family; Region: EamA; pfam00892 590998002875 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 590998002876 MarR family; Region: MarR_2; pfam12802 590998002877 MarR family; Region: MarR_2; cl17246 590998002878 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 590998002879 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 590998002880 dimer interface [polypeptide binding]; other site 590998002881 active site 590998002882 glycine-pyridoxal phosphate binding site [chemical binding]; other site 590998002883 folate binding site [chemical binding]; other site 590998002884 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 590998002885 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 590998002886 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 590998002887 homodimer interface [polypeptide binding]; other site 590998002888 NADP binding site [chemical binding]; other site 590998002889 substrate binding site [chemical binding]; other site 590998002890 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 590998002891 dimer interface [polypeptide binding]; other site 590998002892 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 590998002893 putative catalytic site [active] 590998002894 putative metal binding site [ion binding]; other site 590998002895 putative phosphate binding site [ion binding]; other site 590998002896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998002897 Coenzyme A binding pocket [chemical binding]; other site 590998002898 H+ Antiporter protein; Region: 2A0121; TIGR00900 590998002899 Predicted transcriptional regulator [Transcription]; Region: COG2345 590998002900 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998002901 putative DNA binding site [nucleotide binding]; other site 590998002902 putative Zn2+ binding site [ion binding]; other site 590998002903 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 590998002904 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 590998002905 FtsX-like permease family; Region: FtsX; pfam02687 590998002906 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 590998002907 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 590998002908 Walker A/P-loop; other site 590998002909 ATP binding site [chemical binding]; other site 590998002910 Q-loop/lid; other site 590998002911 ABC transporter signature motif; other site 590998002912 Walker B; other site 590998002913 D-loop; other site 590998002914 H-loop/switch region; other site 590998002915 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 590998002916 FtsX-like permease family; Region: FtsX; pfam02687 590998002917 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 590998002918 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 590998002919 Walker A/P-loop; other site 590998002920 ATP binding site [chemical binding]; other site 590998002921 Q-loop/lid; other site 590998002922 ABC transporter signature motif; other site 590998002923 Walker B; other site 590998002924 D-loop; other site 590998002925 H-loop/switch region; other site 590998002926 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 590998002927 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 590998002928 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 590998002929 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 590998002930 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 590998002931 nucleotide binding site/active site [active] 590998002932 HIT family signature motif; other site 590998002933 catalytic residue [active] 590998002934 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 590998002935 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 590998002936 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 590998002937 Domain of unknown function DUF59; Region: DUF59; cl00941 590998002938 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 590998002939 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 590998002940 Walker A motif; other site 590998002941 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 590998002942 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 590998002943 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 590998002944 MgtE intracellular N domain; Region: MgtE_N; smart00924 590998002945 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 590998002946 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 590998002947 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 590998002948 active site 590998002949 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 590998002950 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 590998002951 active site 590998002952 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 590998002953 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 590998002954 helicase 45; Provisional; Region: PTZ00424 590998002955 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 590998002956 ATP binding site [chemical binding]; other site 590998002957 Mg++ binding site [ion binding]; other site 590998002958 motif III; other site 590998002959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 590998002960 nucleotide binding region [chemical binding]; other site 590998002961 ATP-binding site [chemical binding]; other site 590998002962 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 590998002963 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 590998002964 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998002965 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 590998002966 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 590998002967 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 590998002968 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 590998002969 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 590998002970 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 590998002971 active site 590998002972 substrate binding site [chemical binding]; other site 590998002973 ATP binding site [chemical binding]; other site 590998002974 Phosphotransferase enzyme family; Region: APH; pfam01636 590998002975 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 590998002976 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 590998002977 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 590998002978 putative NADH binding site [chemical binding]; other site 590998002979 putative active site [active] 590998002980 nudix motif; other site 590998002981 putative metal binding site [ion binding]; other site 590998002982 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 590998002983 catalytic residues [active] 590998002984 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 590998002985 Part of AAA domain; Region: AAA_19; pfam13245 590998002986 Family description; Region: UvrD_C_2; pfam13538 590998002987 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 590998002988 HRDC domain; Region: HRDC; pfam00570 590998002989 Transcription factor WhiB; Region: Whib; pfam02467 590998002990 Protein of unknown function DUF45; Region: DUF45; cl00636 590998002991 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 590998002992 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 590998002993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998002994 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 590998002995 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 590998002996 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 590998002997 Uncharacterized conserved protein [Function unknown]; Region: COG1615 590998002998 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 590998002999 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 590998003000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 590998003001 dimerization interface [polypeptide binding]; other site 590998003002 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 590998003003 dimer interface [polypeptide binding]; other site 590998003004 putative CheW interface [polypeptide binding]; other site 590998003005 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 590998003006 dimerization interface [polypeptide binding]; other site 590998003007 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 590998003008 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 590998003009 dimer interface [polypeptide binding]; other site 590998003010 putative CheW interface [polypeptide binding]; other site 590998003011 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 590998003012 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 590998003013 FeS/SAM binding site; other site 590998003014 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 590998003015 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 590998003016 nucleotide binding site [chemical binding]; other site 590998003017 sucrose phosphorylase; Provisional; Region: PRK13840 590998003018 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 590998003019 active site 590998003020 catalytic site [active] 590998003021 CsbD-like; Region: CsbD; pfam05532 590998003022 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 590998003023 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 590998003024 active site 590998003025 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 590998003026 non-prolyl cis peptide bond; other site 590998003027 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 590998003028 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 590998003029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998003030 dimer interface [polypeptide binding]; other site 590998003031 conserved gate region; other site 590998003032 putative PBP binding loops; other site 590998003033 ABC-ATPase subunit interface; other site 590998003034 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 590998003035 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 590998003036 Walker A/P-loop; other site 590998003037 ATP binding site [chemical binding]; other site 590998003038 Q-loop/lid; other site 590998003039 ABC transporter signature motif; other site 590998003040 Walker B; other site 590998003041 D-loop; other site 590998003042 H-loop/switch region; other site 590998003043 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 590998003044 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 590998003045 substrate binding pocket [chemical binding]; other site 590998003046 membrane-bound complex binding site; other site 590998003047 hinge residues; other site 590998003048 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 590998003049 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 590998003050 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 590998003051 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 590998003052 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 590998003053 active site 590998003054 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 590998003055 dimer interface [polypeptide binding]; other site 590998003056 non-prolyl cis peptide bond; other site 590998003057 insertion regions; other site 590998003058 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 590998003059 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 590998003060 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 590998003061 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 590998003062 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 590998003063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998003064 S-adenosylmethionine binding site [chemical binding]; other site 590998003065 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 590998003066 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 590998003067 active site 590998003068 metal binding site [ion binding]; metal-binding site 590998003069 ANTAR domain; Region: ANTAR; pfam03861 590998003070 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 590998003071 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 590998003072 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 590998003073 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 590998003074 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 590998003075 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 590998003076 Predicted transcriptional regulators [Transcription]; Region: COG1695 590998003077 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998003078 dimerization interface [polypeptide binding]; other site 590998003079 putative DNA binding site [nucleotide binding]; other site 590998003080 putative Zn2+ binding site [ion binding]; other site 590998003081 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 590998003082 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 590998003083 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 590998003084 Walker A/P-loop; other site 590998003085 ATP binding site [chemical binding]; other site 590998003086 Q-loop/lid; other site 590998003087 ABC transporter signature motif; other site 590998003088 Walker B; other site 590998003089 D-loop; other site 590998003090 H-loop/switch region; other site 590998003091 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 590998003092 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 590998003093 conserved gate region; other site 590998003094 ABC-ATPase subunit interface; other site 590998003095 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 590998003096 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 590998003097 putative metal binding residues [ion binding]; other site 590998003098 signature motif; other site 590998003099 dimer interface [polypeptide binding]; other site 590998003100 active site 590998003101 polyP binding site; other site 590998003102 substrate binding site [chemical binding]; other site 590998003103 acceptor-phosphate pocket; other site 590998003104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998003105 NADH(P)-binding; Region: NAD_binding_10; pfam13460 590998003106 NAD(P) binding site [chemical binding]; other site 590998003107 active site 590998003108 Cupin; Region: Cupin_6; pfam12852 590998003109 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 590998003110 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998003111 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998003112 ligand binding site [chemical binding]; other site 590998003113 dimerization interface [polypeptide binding]; other site 590998003114 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 590998003115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 590998003116 Protein of unknown function (DUF664); Region: DUF664; pfam04978 590998003117 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 590998003118 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 590998003119 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 590998003120 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 590998003121 putative dimer interface [polypeptide binding]; other site 590998003122 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 590998003123 iron-sulfur cluster [ion binding]; other site 590998003124 [2Fe-2S] cluster binding site [ion binding]; other site 590998003125 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 590998003126 CrcB-like protein; Region: CRCB; cl09114 590998003127 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 590998003128 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 590998003129 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 590998003130 AlkA N-terminal domain; Region: AlkA_N; cl05528 590998003131 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 590998003132 minor groove reading motif; other site 590998003133 helix-hairpin-helix signature motif; other site 590998003134 substrate binding pocket [chemical binding]; other site 590998003135 active site 590998003136 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 590998003137 Mechanosensitive ion channel; Region: MS_channel; pfam00924 590998003138 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 590998003139 Predicted transcriptional regulator [Transcription]; Region: COG2378 590998003140 HTH domain; Region: HTH_11; pfam08279 590998003141 WYL domain; Region: WYL; pfam13280 590998003142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998003143 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 590998003144 Walker A/P-loop; other site 590998003145 ATP binding site [chemical binding]; other site 590998003146 Q-loop/lid; other site 590998003147 ABC transporter signature motif; other site 590998003148 Walker B; other site 590998003149 D-loop; other site 590998003150 H-loop/switch region; other site 590998003151 ABC-2 type transporter; Region: ABC2_membrane; cl17235 590998003152 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 590998003153 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 590998003154 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 590998003155 DNA binding site [nucleotide binding] 590998003156 active site 590998003157 Fic/DOC family; Region: Fic; cl00960 590998003158 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 590998003159 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 590998003160 NAD binding site [chemical binding]; other site 590998003161 catalytic Zn binding site [ion binding]; other site 590998003162 structural Zn binding site [ion binding]; other site 590998003163 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 590998003164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998003165 NAD(P) binding site [chemical binding]; other site 590998003166 active site 590998003167 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 590998003168 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 590998003169 classical (c) SDRs; Region: SDR_c; cd05233 590998003170 NAD(P) binding site [chemical binding]; other site 590998003171 active site 590998003172 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 590998003173 hydrophobic ligand binding site; other site 590998003174 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 590998003175 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 590998003176 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 590998003177 DNA binding residues [nucleotide binding] 590998003178 TOBE domain; Region: TOBE; cl01440 590998003179 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 590998003180 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 590998003181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998003182 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 590998003183 putative PBP binding loops; other site 590998003184 ABC-ATPase subunit interface; other site 590998003185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998003186 Walker A/P-loop; other site 590998003187 ATP binding site [chemical binding]; other site 590998003188 ABC transporter; Region: ABC_tran; pfam00005 590998003189 Q-loop/lid; other site 590998003190 ABC transporter signature motif; other site 590998003191 Walker B; other site 590998003192 D-loop; other site 590998003193 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 590998003194 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 590998003195 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 590998003196 molybdopterin cofactor binding site; other site 590998003197 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 590998003198 molybdopterin cofactor binding site; other site 590998003199 Flavodoxin; Region: Flavodoxin_1; pfam00258 590998003200 FAD binding domain; Region: FAD_binding_1; pfam00667 590998003201 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 590998003202 FAD binding pocket [chemical binding]; other site 590998003203 conserved FAD binding motif [chemical binding]; other site 590998003204 phosphate binding motif [ion binding]; other site 590998003205 beta-alpha-beta structure motif; other site 590998003206 NAD binding pocket [chemical binding]; other site 590998003207 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 590998003208 Moco binding site; other site 590998003209 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 590998003210 metal coordination site [ion binding]; other site 590998003211 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 590998003212 nucleotide binding site/active site [active] 590998003213 HIT family signature motif; other site 590998003214 catalytic residue [active] 590998003215 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 590998003216 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 590998003217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998003218 Walker A/P-loop; other site 590998003219 ATP binding site [chemical binding]; other site 590998003220 Q-loop/lid; other site 590998003221 ABC transporter signature motif; other site 590998003222 Walker B; other site 590998003223 D-loop; other site 590998003224 H-loop/switch region; other site 590998003225 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 590998003226 nitrite reductase subunit NirD; Provisional; Region: PRK14989 590998003227 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 590998003228 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 590998003229 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 590998003230 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 590998003231 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 590998003232 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 590998003233 homodimer interface [polypeptide binding]; other site 590998003234 active site 590998003235 SAM binding site [chemical binding]; other site 590998003236 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 590998003237 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 590998003238 active site 590998003239 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 590998003240 DNA binding site [nucleotide binding] 590998003241 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 590998003242 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 590998003243 putative active site [active] 590998003244 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 590998003245 active site 590998003246 LabA_like proteins; Region: LabA_like; cd06167 590998003247 putative metal binding site [ion binding]; other site 590998003248 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 590998003249 Cellulose binding domain; Region: CBM_2; pfam00553 590998003250 Transcriptional regulators [Transcription]; Region: MarR; COG1846 590998003251 MarR family; Region: MarR_2; pfam12802 590998003252 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 590998003253 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 590998003254 Catalytic domain of Protein Kinases; Region: PKc; cd00180 590998003255 active site 590998003256 ATP binding site [chemical binding]; other site 590998003257 substrate binding site [chemical binding]; other site 590998003258 activation loop (A-loop); other site 590998003259 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998003260 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998003261 DNA binding site [nucleotide binding] 590998003262 domain linker motif; other site 590998003263 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 590998003264 putative dimerization interface [polypeptide binding]; other site 590998003265 putative ligand binding site [chemical binding]; other site 590998003266 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 590998003267 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 590998003268 active site 590998003269 catalytic site [active] 590998003270 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998003271 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 590998003272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998003273 dimer interface [polypeptide binding]; other site 590998003274 conserved gate region; other site 590998003275 putative PBP binding loops; other site 590998003276 ABC-ATPase subunit interface; other site 590998003277 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998003278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998003279 dimer interface [polypeptide binding]; other site 590998003280 conserved gate region; other site 590998003281 putative PBP binding loops; other site 590998003282 ABC-ATPase subunit interface; other site 590998003283 ferrochelatase; Reviewed; Region: hemH; PRK00035 590998003284 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 590998003285 C-terminal domain interface [polypeptide binding]; other site 590998003286 active site 590998003287 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 590998003288 active site 590998003289 N-terminal domain interface [polypeptide binding]; other site 590998003290 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 590998003291 META domain; Region: META; pfam03724 590998003292 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 590998003293 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 590998003294 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 590998003295 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 590998003296 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 590998003297 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 590998003298 NAD(P) binding site [chemical binding]; other site 590998003299 Proline dehydrogenase; Region: Pro_dh; cl03282 590998003300 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 590998003301 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 590998003302 NAD(P) binding site [chemical binding]; other site 590998003303 catalytic residues [active] 590998003304 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998003305 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998003306 DNA binding site [nucleotide binding] 590998003307 domain linker motif; other site 590998003308 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 590998003309 putative dimerization interface [polypeptide binding]; other site 590998003310 putative ligand binding site [chemical binding]; other site 590998003311 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998003312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998003313 dimer interface [polypeptide binding]; other site 590998003314 conserved gate region; other site 590998003315 putative PBP binding loops; other site 590998003316 ABC-ATPase subunit interface; other site 590998003317 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 590998003318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998003319 ABC-ATPase subunit interface; other site 590998003320 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998003321 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 590998003322 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 590998003323 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 590998003324 PAS fold; Region: PAS_4; pfam08448 590998003325 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 590998003326 Histidine kinase; Region: HisKA_2; pfam07568 590998003327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998003328 ATP binding site [chemical binding]; other site 590998003329 G-X-G motif; other site 590998003330 Patatin-like phospholipase; Region: Patatin; pfam01734 590998003331 active site 590998003332 nucleophile elbow; other site 590998003333 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 590998003334 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 590998003335 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 590998003336 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 590998003337 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 590998003338 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 590998003339 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 590998003340 Protein of unknown function (DUF796); Region: DUF796; pfam05638 590998003341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 590998003342 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 590998003343 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 590998003344 putative active site [active] 590998003345 catalytic site [active] 590998003346 putative metal binding site [ion binding]; other site 590998003347 Protein of unknown function (DUF664); Region: DUF664; pfam04978 590998003348 DinB superfamily; Region: DinB_2; pfam12867 590998003349 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 590998003350 G1 box; other site 590998003351 GTP/Mg2+ binding site [chemical binding]; other site 590998003352 FOG: WD40 repeat [General function prediction only]; Region: COG2319 590998003353 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 590998003354 structural tetrad; other site 590998003355 CHAT domain; Region: CHAT; cl17868 590998003356 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; cl11685 590998003357 SIR2-like domain; Region: SIR2_2; pfam13289 590998003358 Acylphosphatase; Region: Acylphosphatase; pfam00708 590998003359 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 590998003360 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 590998003361 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 590998003362 S-ribosylhomocysteinase; Provisional; Region: PRK02260 590998003363 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 590998003364 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 590998003365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998003366 Walker A/P-loop; other site 590998003367 ATP binding site [chemical binding]; other site 590998003368 Q-loop/lid; other site 590998003369 ABC transporter signature motif; other site 590998003370 Walker B; other site 590998003371 D-loop; other site 590998003372 H-loop/switch region; other site 590998003373 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 590998003374 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 590998003375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998003376 active site 590998003377 phosphorylation site [posttranslational modification] 590998003378 intermolecular recognition site; other site 590998003379 dimerization interface [polypeptide binding]; other site 590998003380 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 590998003381 DNA binding site [nucleotide binding] 590998003382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 590998003383 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 590998003384 dimerization interface [polypeptide binding]; other site 590998003385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 590998003386 dimer interface [polypeptide binding]; other site 590998003387 phosphorylation site [posttranslational modification] 590998003388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998003389 ATP binding site [chemical binding]; other site 590998003390 Mg2+ binding site [ion binding]; other site 590998003391 G-X-G motif; other site 590998003392 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 590998003393 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 590998003394 ChaB; Region: ChaB; pfam06150 590998003395 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 590998003396 Histidine kinase; Region: HisKA_3; pfam07730 590998003397 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 590998003398 ATP binding site [chemical binding]; other site 590998003399 Mg2+ binding site [ion binding]; other site 590998003400 G-X-G motif; other site 590998003401 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998003402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998003403 active site 590998003404 phosphorylation site [posttranslational modification] 590998003405 intermolecular recognition site; other site 590998003406 dimerization interface [polypeptide binding]; other site 590998003407 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998003408 dimerization interface [polypeptide binding]; other site 590998003409 DNA binding residues [nucleotide binding] 590998003410 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 590998003411 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 590998003412 minor groove reading motif; other site 590998003413 helix-hairpin-helix signature motif; other site 590998003414 active site 590998003415 Protein of unknown function DUF72; Region: DUF72; pfam01904 590998003416 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 590998003417 anti sigma factor interaction site; other site 590998003418 regulatory phosphorylation site [posttranslational modification]; other site 590998003419 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 590998003420 RNA binding surface [nucleotide binding]; other site 590998003421 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 590998003422 active site 590998003423 catalytic triad [active] 590998003424 oxyanion hole [active] 590998003425 Cellulose binding domain; Region: CBM_2; pfam00553 590998003426 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 590998003427 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 590998003428 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 590998003429 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 590998003430 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 590998003431 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 590998003432 [4Fe-4S] binding site [ion binding]; other site 590998003433 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 590998003434 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 590998003435 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 590998003436 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 590998003437 molybdopterin cofactor binding site; other site 590998003438 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 590998003439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 590998003440 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998003441 dimerization interface [polypeptide binding]; other site 590998003442 putative DNA binding site [nucleotide binding]; other site 590998003443 Predicted transcriptional regulator [Transcription]; Region: COG2345 590998003444 putative Zn2+ binding site [ion binding]; other site 590998003445 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 590998003446 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 590998003447 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 590998003448 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 590998003449 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 590998003450 active site 590998003451 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 590998003452 Pectate lyase; Region: Pectate_lyase; pfam03211 590998003453 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 590998003454 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 590998003455 active site 590998003456 dimer interface [polypeptide binding]; other site 590998003457 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 590998003458 dimer interface [polypeptide binding]; other site 590998003459 active site 590998003460 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 590998003461 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 590998003462 ligand binding site [chemical binding]; other site 590998003463 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 590998003464 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 590998003465 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 590998003466 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 590998003467 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998003468 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 590998003469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998003470 dimer interface [polypeptide binding]; other site 590998003471 conserved gate region; other site 590998003472 putative PBP binding loops; other site 590998003473 ABC-ATPase subunit interface; other site 590998003474 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998003475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998003476 dimer interface [polypeptide binding]; other site 590998003477 conserved gate region; other site 590998003478 putative PBP binding loops; other site 590998003479 ABC-ATPase subunit interface; other site 590998003480 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 590998003481 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 590998003482 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 590998003483 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 590998003484 active site 590998003485 trimer interface [polypeptide binding]; other site 590998003486 allosteric site; other site 590998003487 active site lid [active] 590998003488 hexamer (dimer of trimers) interface [polypeptide binding]; other site 590998003489 Predicted transcriptional regulators [Transcription]; Region: COG1695 590998003490 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 590998003491 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 590998003492 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 590998003493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 590998003494 ATP binding site [chemical binding]; other site 590998003495 putative Mg++ binding site [ion binding]; other site 590998003496 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 590998003497 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 590998003498 active site 590998003499 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 590998003500 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 590998003501 glutamate racemase; Provisional; Region: PRK00865 590998003502 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 590998003503 ribonuclease PH; Reviewed; Region: rph; PRK00173 590998003504 Ribonuclease PH; Region: RNase_PH_bact; cd11362 590998003505 hexamer interface [polypeptide binding]; other site 590998003506 active site 590998003507 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 590998003508 active site 590998003509 dimerization interface [polypeptide binding]; other site 590998003510 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 590998003511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998003512 Walker A/P-loop; other site 590998003513 ATP binding site [chemical binding]; other site 590998003514 Q-loop/lid; other site 590998003515 ABC transporter signature motif; other site 590998003516 Walker B; other site 590998003517 D-loop; other site 590998003518 H-loop/switch region; other site 590998003519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998003520 Walker A/P-loop; other site 590998003521 ATP binding site [chemical binding]; other site 590998003522 Q-loop/lid; other site 590998003523 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 590998003524 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 590998003525 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 590998003526 catalytic residues [active] 590998003527 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 590998003528 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 590998003529 catalytic triad [active] 590998003530 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 590998003531 oligomerisation interface [polypeptide binding]; other site 590998003532 mobile loop; other site 590998003533 roof hairpin; other site 590998003534 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 590998003535 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 590998003536 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 590998003537 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 590998003538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998003539 putative PBP binding loops; other site 590998003540 ABC-ATPase subunit interface; other site 590998003541 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 590998003542 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 590998003543 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 590998003544 Walker A/P-loop; other site 590998003545 ATP binding site [chemical binding]; other site 590998003546 Q-loop/lid; other site 590998003547 ABC transporter signature motif; other site 590998003548 Walker B; other site 590998003549 D-loop; other site 590998003550 H-loop/switch region; other site 590998003551 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 590998003552 ATP-grasp domain; Region: ATP-grasp_4; cl17255 590998003553 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 590998003554 catalytic site [active] 590998003555 putative active site [active] 590998003556 putative substrate binding site [chemical binding]; other site 590998003557 dimer interface [polypeptide binding]; other site 590998003558 putative transporter; Provisional; Region: PRK11021 590998003559 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 590998003560 G2 box; other site 590998003561 Switch I region; other site 590998003562 G3 box; other site 590998003563 Switch II region; other site 590998003564 G4 box; other site 590998003565 YfjP GTPase; Region: YfjP; cd11383 590998003566 G1 box; other site 590998003567 GTP/Mg2+ binding site [chemical binding]; other site 590998003568 Switch I region; other site 590998003569 G2 box; other site 590998003570 Switch II region; other site 590998003571 G3 box; other site 590998003572 G4 box; other site 590998003573 G5 box; other site 590998003574 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 590998003575 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 590998003576 dimer interface [polypeptide binding]; other site 590998003577 ssDNA binding site [nucleotide binding]; other site 590998003578 tetramer (dimer of dimers) interface [polypeptide binding]; other site 590998003579 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 590998003580 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 590998003581 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 590998003582 ABC transporter; Region: ABC_tran_2; pfam12848 590998003583 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 590998003584 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 590998003585 G1 box; other site 590998003586 GTP/Mg2+ binding site [chemical binding]; other site 590998003587 G2 box; other site 590998003588 Dynamin family; Region: Dynamin_N; pfam00350 590998003589 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 590998003590 G1 box; other site 590998003591 GTP/Mg2+ binding site [chemical binding]; other site 590998003592 G2 box; other site 590998003593 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 590998003594 G3 box; other site 590998003595 Switch II region; other site 590998003596 GTP/Mg2+ binding site [chemical binding]; other site 590998003597 G4 box; other site 590998003598 G5 box; other site 590998003599 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 590998003600 active site 590998003601 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 590998003602 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 590998003603 active site 590998003604 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 590998003605 NADH(P)-binding; Region: NAD_binding_10; pfam13460 590998003606 putative NAD(P) binding site [chemical binding]; other site 590998003607 putative active site [active] 590998003608 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 590998003609 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 590998003610 active site 590998003611 DNA binding site [nucleotide binding] 590998003612 Int/Topo IB signature motif; other site 590998003613 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 590998003614 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 590998003615 active site 590998003616 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 590998003617 catalytic triad [active] 590998003618 dimer interface [polypeptide binding]; other site 590998003619 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 590998003620 apolar tunnel; other site 590998003621 heme binding site [chemical binding]; other site 590998003622 dimerization interface [polypeptide binding]; other site 590998003623 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 590998003624 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 590998003625 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 590998003626 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 590998003627 active site turn [active] 590998003628 phosphorylation site [posttranslational modification] 590998003629 Mechanosensitive ion channel; Region: MS_channel; pfam00924 590998003630 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 590998003631 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 590998003632 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 590998003633 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 590998003634 topology modulation protein; Reviewed; Region: PRK08118 590998003635 AAA domain; Region: AAA_17; pfam13207 590998003636 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 590998003637 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 590998003638 Zn binding site [ion binding]; other site 590998003639 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 590998003640 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 590998003641 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 590998003642 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 590998003643 active site 590998003644 Zn binding site [ion binding]; other site 590998003645 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 590998003646 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 590998003647 dimerization domain swap beta strand [polypeptide binding]; other site 590998003648 regulatory protein interface [polypeptide binding]; other site 590998003649 active site 590998003650 regulatory phosphorylation site [posttranslational modification]; other site 590998003651 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 590998003652 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 590998003653 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 590998003654 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 590998003655 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 590998003656 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 590998003657 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 590998003658 DNA-binding site [nucleotide binding]; DNA binding site 590998003659 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 590998003660 phosphotransferase system, EIIB; Region: PTS_EIIB; pfam00367 590998003661 active site turn [active] 590998003662 phosphorylation site [posttranslational modification] 590998003663 phosphotransferase system, EIIB; Region: PTS_EIIB; pfam00367 590998003664 active site turn [active] 590998003665 phosphorylation site [posttranslational modification] 590998003666 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 590998003667 HPr interaction site; other site 590998003668 glycerol kinase (GK) interaction site [polypeptide binding]; other site 590998003669 active site 590998003670 phosphorylation site [posttranslational modification] 590998003671 CutC family; Region: CutC; cl01218 590998003672 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 590998003673 hypothetical protein; Provisional; Region: PRK01346 590998003674 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 590998003675 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 590998003676 DNA binding site [nucleotide binding] 590998003677 active site 590998003678 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 590998003679 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 590998003680 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 590998003681 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 590998003682 DNA-binding site [nucleotide binding]; DNA binding site 590998003683 serine O-acetyltransferase; Region: cysE; TIGR01172 590998003684 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 590998003685 trimer interface [polypeptide binding]; other site 590998003686 active site 590998003687 substrate binding site [chemical binding]; other site 590998003688 CoA binding site [chemical binding]; other site 590998003689 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 590998003690 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 590998003691 dimer interface [polypeptide binding]; other site 590998003692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998003693 catalytic residue [active] 590998003694 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 590998003695 active site 590998003696 catalytic triad [active] 590998003697 oxyanion hole [active] 590998003698 PQ loop repeat; Region: PQ-loop; cl17546 590998003699 Methyltransferase domain; Region: Methyltransf_31; pfam13847 590998003700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998003701 S-adenosylmethionine binding site [chemical binding]; other site 590998003702 DNA binding site [nucleotide binding] 590998003703 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 590998003704 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 590998003705 Predicted ATPase [General function prediction only]; Region: COG3903 590998003706 Methyltransferase domain; Region: Methyltransf_23; pfam13489 590998003707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998003708 S-adenosylmethionine binding site [chemical binding]; other site 590998003709 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 590998003710 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 590998003711 trigger factor; Provisional; Region: tig; PRK01490 590998003712 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 590998003713 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 590998003714 Clp protease; Region: CLP_protease; pfam00574 590998003715 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 590998003716 oligomer interface [polypeptide binding]; other site 590998003717 active site residues [active] 590998003718 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 590998003719 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 590998003720 oligomer interface [polypeptide binding]; other site 590998003721 active site residues [active] 590998003722 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 590998003723 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 590998003724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 590998003725 Walker A motif; other site 590998003726 ATP binding site [chemical binding]; other site 590998003727 Walker B motif; other site 590998003728 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 590998003729 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 590998003730 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 590998003731 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 590998003732 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 590998003733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 590998003734 active site 590998003735 motif I; other site 590998003736 motif II; other site 590998003737 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 590998003738 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 590998003739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998003740 Walker A/P-loop; other site 590998003741 ATP binding site [chemical binding]; other site 590998003742 Q-loop/lid; other site 590998003743 ABC transporter signature motif; other site 590998003744 Walker B; other site 590998003745 D-loop; other site 590998003746 H-loop/switch region; other site 590998003747 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 590998003748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 590998003749 chorismate mutase; Provisional; Region: PRK09239 590998003750 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 590998003751 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 590998003752 acyl-activating enzyme (AAE) consensus motif; other site 590998003753 putative AMP binding site [chemical binding]; other site 590998003754 putative active site [active] 590998003755 putative CoA binding site [chemical binding]; other site 590998003756 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 590998003757 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 590998003758 active site 590998003759 HIGH motif; other site 590998003760 nucleotide binding site [chemical binding]; other site 590998003761 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 590998003762 active site 590998003763 KMSKS motif; other site 590998003764 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 590998003765 tRNA binding surface [nucleotide binding]; other site 590998003766 anticodon binding site; other site 590998003767 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 590998003768 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 590998003769 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 590998003770 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 590998003771 HicB family; Region: HicB; pfam05534 590998003772 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 590998003773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998003774 Walker A/P-loop; other site 590998003775 ATP binding site [chemical binding]; other site 590998003776 Q-loop/lid; other site 590998003777 ABC transporter signature motif; other site 590998003778 Walker B; other site 590998003779 D-loop; other site 590998003780 H-loop/switch region; other site 590998003781 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 590998003782 ABC-2 type transporter; Region: ABC2_membrane; cl17235 590998003783 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 590998003784 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 590998003785 minor groove reading motif; other site 590998003786 helix-hairpin-helix signature motif; other site 590998003787 active site 590998003788 Guanylyl transferase CofC like; Region: CofC; cl17472 590998003789 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 590998003790 phosphate binding site [ion binding]; other site 590998003791 dimer interface [polypeptide binding]; other site 590998003792 proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873 590998003793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998003794 Walker A/P-loop; other site 590998003795 ATP binding site [chemical binding]; other site 590998003796 Q-loop/lid; other site 590998003797 ABC transporter signature motif; other site 590998003798 Walker B; other site 590998003799 D-loop; other site 590998003800 H-loop/switch region; other site 590998003801 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 590998003802 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 590998003803 dimer interface [polypeptide binding]; other site 590998003804 putative PBP binding regions; other site 590998003805 ABC-ATPase subunit interface; other site 590998003806 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 590998003807 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 590998003808 putative ligand binding residues [chemical binding]; other site 590998003809 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 590998003810 DNA-binding site [nucleotide binding]; DNA binding site 590998003811 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 590998003812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998003813 homodimer interface [polypeptide binding]; other site 590998003814 catalytic residue [active] 590998003815 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 590998003816 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 590998003817 active site 590998003818 catalytic triad [active] 590998003819 dimer interface [polypeptide binding]; other site 590998003820 phenylhydantoinase; Validated; Region: PRK08323 590998003821 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 590998003822 tetramer interface [polypeptide binding]; other site 590998003823 active site 590998003824 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 590998003825 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 590998003826 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 590998003827 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 590998003828 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 590998003829 Walker A/P-loop; other site 590998003830 ATP binding site [chemical binding]; other site 590998003831 Q-loop/lid; other site 590998003832 ABC transporter signature motif; other site 590998003833 Walker B; other site 590998003834 D-loop; other site 590998003835 H-loop/switch region; other site 590998003836 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 590998003837 dimer interface [polypeptide binding]; other site 590998003838 conserved gate region; other site 590998003839 ABC-ATPase subunit interface; other site 590998003840 NMT1/THI5 like; Region: NMT1; pfam09084 590998003841 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 590998003842 hypothetical protein; Provisional; Region: PRK06062 590998003843 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 590998003844 inhibitor-cofactor binding pocket; inhibition site 590998003845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998003846 catalytic residue [active] 590998003847 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 590998003848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998003849 NAD(P) binding site [chemical binding]; other site 590998003850 active site 590998003851 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 590998003852 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 590998003853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998003854 Walker A/P-loop; other site 590998003855 ATP binding site [chemical binding]; other site 590998003856 Q-loop/lid; other site 590998003857 ABC transporter signature motif; other site 590998003858 Walker B; other site 590998003859 D-loop; other site 590998003860 H-loop/switch region; other site 590998003861 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 590998003862 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 590998003863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998003864 Walker A/P-loop; other site 590998003865 ATP binding site [chemical binding]; other site 590998003866 Q-loop/lid; other site 590998003867 ABC transporter signature motif; other site 590998003868 Walker B; other site 590998003869 D-loop; other site 590998003870 H-loop/switch region; other site 590998003871 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 590998003872 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 590998003873 active site 590998003874 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998003875 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998003876 DNA binding residues [nucleotide binding] 590998003877 dimerization interface [polypeptide binding]; other site 590998003878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998003879 ATP binding site [chemical binding]; other site 590998003880 Mg2+ binding site [ion binding]; other site 590998003881 G-X-G motif; other site 590998003882 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 590998003883 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 590998003884 DNA binding residues [nucleotide binding] 590998003885 dimer interface [polypeptide binding]; other site 590998003886 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 590998003887 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 590998003888 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 590998003889 motif II; other site 590998003890 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 590998003891 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 590998003892 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 590998003893 active site 590998003894 nucleotide binding site [chemical binding]; other site 590998003895 HIGH motif; other site 590998003896 KMSKS motif; other site 590998003897 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 590998003898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 590998003899 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 590998003900 AMP binding site [chemical binding]; other site 590998003901 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 590998003902 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 590998003903 substrate binding site [chemical binding]; other site 590998003904 active site 590998003905 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 590998003906 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 590998003907 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 590998003908 HIGH motif; other site 590998003909 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 590998003910 active site 590998003911 KMSKS motif; other site 590998003912 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 590998003913 tRNA binding surface [nucleotide binding]; other site 590998003914 anticodon binding site; other site 590998003915 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 590998003916 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 590998003917 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 590998003918 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 590998003919 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 590998003920 DAK2 domain; Region: Dak2; cl03685 590998003921 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 590998003922 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 590998003923 dimerization domain swap beta strand [polypeptide binding]; other site 590998003924 regulatory protein interface [polypeptide binding]; other site 590998003925 active site 590998003926 regulatory phosphorylation site [posttranslational modification]; other site 590998003927 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 590998003928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998003929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998003930 Major Facilitator Superfamily; Region: MFS_1; pfam07690 590998003931 putative substrate translocation pore; other site 590998003932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998003933 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 590998003934 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 590998003935 active site 590998003936 multimer interface [polypeptide binding]; other site 590998003937 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 590998003938 AAA domain; Region: AAA_23; pfam13476 590998003939 Walker A/P-loop; other site 590998003940 ATP binding site [chemical binding]; other site 590998003941 Q-loop/lid; other site 590998003942 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 590998003943 ABC transporter signature motif; other site 590998003944 Walker B; other site 590998003945 D-loop; other site 590998003946 H-loop/switch region; other site 590998003947 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 590998003948 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 590998003949 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 590998003950 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 590998003951 Nitrogen regulatory protein P-II; Region: P-II; smart00938 590998003952 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 590998003953 PII uridylyl-transferase; Provisional; Region: PRK03381 590998003954 metal binding triad; other site 590998003955 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 590998003956 signal recognition particle protein; Provisional; Region: PRK10867 590998003957 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 590998003958 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 590998003959 P loop; other site 590998003960 GTP binding site [chemical binding]; other site 590998003961 Signal peptide binding domain; Region: SRP_SPB; pfam02978 590998003962 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 590998003963 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 590998003964 active site 590998003965 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 590998003966 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 590998003967 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 590998003968 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 590998003969 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 590998003970 RimM N-terminal domain; Region: RimM; pfam01782 590998003971 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 590998003972 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 590998003973 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 590998003974 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 590998003975 Catalytic site [active] 590998003976 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 590998003977 RNA/DNA hybrid binding site [nucleotide binding]; other site 590998003978 active site 590998003979 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 590998003980 hypothetical protein; Reviewed; Region: PRK12497 590998003981 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 590998003982 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 590998003983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 590998003984 Walker A motif; other site 590998003985 ATP binding site [chemical binding]; other site 590998003986 Walker B motif; other site 590998003987 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 590998003988 DNA protecting protein DprA; Region: dprA; TIGR00732 590998003989 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 590998003990 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 590998003991 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998003992 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 590998003993 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 590998003994 DNA binding residues [nucleotide binding] 590998003995 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 590998003996 rRNA interaction site [nucleotide binding]; other site 590998003997 S8 interaction site; other site 590998003998 putative laminin-1 binding site; other site 590998003999 elongation factor Ts; Provisional; Region: tsf; PRK09377 590998004000 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 590998004001 Elongation factor TS; Region: EF_TS; pfam00889 590998004002 Elongation factor TS; Region: EF_TS; pfam00889 590998004003 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 590998004004 putative nucleotide binding site [chemical binding]; other site 590998004005 uridine monophosphate binding site [chemical binding]; other site 590998004006 homohexameric interface [polypeptide binding]; other site 590998004007 ribosome recycling factor; Reviewed; Region: frr; PRK00083 590998004008 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 590998004009 hinge region; other site 590998004010 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 590998004011 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 590998004012 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 590998004013 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 590998004014 FeS/SAM binding site; other site 590998004015 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 590998004016 DivIVA domain; Region: DivI1A_domain; TIGR03544 590998004017 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 590998004018 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 590998004019 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 590998004020 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 590998004021 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 590998004022 FAD dependent oxidoreductase; Region: DAO; pfam01266 590998004023 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 590998004024 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 590998004025 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 590998004026 active site 590998004027 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 590998004028 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 590998004029 putative substrate binding region [chemical binding]; other site 590998004030 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 590998004031 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 590998004032 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 590998004033 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 590998004034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 590998004035 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 590998004036 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 590998004037 putative DNA binding site [nucleotide binding]; other site 590998004038 catalytic residue [active] 590998004039 putative H2TH interface [polypeptide binding]; other site 590998004040 putative catalytic residues [active] 590998004041 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 590998004042 prolyl-tRNA synthetase; Provisional; Region: PRK09194 590998004043 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 590998004044 motif 1; other site 590998004045 dimer interface [polypeptide binding]; other site 590998004046 active site 590998004047 motif 2; other site 590998004048 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 590998004049 putative deacylase active site [active] 590998004050 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 590998004051 active site 590998004052 motif 3; other site 590998004053 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 590998004054 anticodon binding site; other site 590998004055 Sm and related proteins; Region: Sm_like; cl00259 590998004056 ribosome maturation protein RimP; Reviewed; Region: PRK00092 590998004057 Sm and related proteins; Region: Sm_like; cl00259 590998004058 heptamer interface [polypeptide binding]; other site 590998004059 Sm1 motif; other site 590998004060 hexamer interface [polypeptide binding]; other site 590998004061 RNA binding site [nucleotide binding]; other site 590998004062 Sm2 motif; other site 590998004063 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 590998004064 NusA N-terminal domain; Region: NusA_N; pfam08529 590998004065 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 590998004066 RNA binding site [nucleotide binding]; other site 590998004067 homodimer interface [polypeptide binding]; other site 590998004068 NusA-like KH domain; Region: KH_5; pfam13184 590998004069 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 590998004070 G-X-X-G motif; other site 590998004071 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 590998004072 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 590998004073 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 590998004074 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 590998004075 G1 box; other site 590998004076 putative GEF interaction site [polypeptide binding]; other site 590998004077 GTP/Mg2+ binding site [chemical binding]; other site 590998004078 Switch I region; other site 590998004079 G2 box; other site 590998004080 G3 box; other site 590998004081 Switch II region; other site 590998004082 G4 box; other site 590998004083 G5 box; other site 590998004084 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 590998004085 Translation-initiation factor 2; Region: IF-2; pfam11987 590998004086 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 590998004087 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 590998004088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998004089 Major Facilitator Superfamily; Region: MFS_1; pfam07690 590998004090 putative substrate translocation pore; other site 590998004091 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998004092 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998004093 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 590998004094 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 590998004095 RNA binding site [nucleotide binding]; other site 590998004096 active site 590998004097 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 590998004098 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 590998004099 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 590998004100 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 590998004101 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 590998004102 Immunoglobulin I-set domain; Region: I-set; pfam07679 590998004103 Immunoglobulin like; Region: IG_like; smart00410 590998004104 Immunoglobulin domain; Region: Ig; cl11960 590998004105 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 590998004106 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 590998004107 active site 590998004108 Riboflavin kinase; Region: Flavokinase; pfam01687 590998004109 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 590998004110 16S/18S rRNA binding site [nucleotide binding]; other site 590998004111 S13e-L30e interaction site [polypeptide binding]; other site 590998004112 25S rRNA binding site [nucleotide binding]; other site 590998004113 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 590998004114 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 590998004115 oligomer interface [polypeptide binding]; other site 590998004116 RNA binding site [nucleotide binding]; other site 590998004117 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 590998004118 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 590998004119 RNase E interface [polypeptide binding]; other site 590998004120 trimer interface [polypeptide binding]; other site 590998004121 active site 590998004122 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 590998004123 putative nucleic acid binding region [nucleotide binding]; other site 590998004124 G-X-X-G motif; other site 590998004125 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 590998004126 RNA binding site [nucleotide binding]; other site 590998004127 domain interface; other site 590998004128 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 590998004129 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 590998004130 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 590998004131 dihydrodipicolinate reductase; Provisional; Region: PRK00048 590998004132 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 590998004133 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 590998004134 AzlC protein; Region: AzlC; pfam03591 590998004135 succinic semialdehyde dehydrogenase; Region: PLN02278 590998004136 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 590998004137 tetramerization interface [polypeptide binding]; other site 590998004138 NAD(P) binding site [chemical binding]; other site 590998004139 catalytic residues [active] 590998004140 thymidylate synthase; Reviewed; Region: thyA; PRK01827 590998004141 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 590998004142 dimerization interface [polypeptide binding]; other site 590998004143 active site 590998004144 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 590998004145 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 590998004146 folate binding site [chemical binding]; other site 590998004147 NADP+ binding site [chemical binding]; other site 590998004148 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 590998004149 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 590998004150 dimer interface [polypeptide binding]; other site 590998004151 active site 590998004152 catalytic residue [active] 590998004153 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 590998004154 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 590998004155 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 590998004156 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 590998004157 EamA-like transporter family; Region: EamA; pfam00892 590998004158 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 590998004159 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 590998004160 conserved cys residue [active] 590998004161 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 590998004162 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 590998004163 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 590998004164 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 590998004165 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 590998004166 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 590998004167 PAS domain S-box; Region: sensory_box; TIGR00229 590998004168 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 590998004169 putative active site [active] 590998004170 heme pocket [chemical binding]; other site 590998004171 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 590998004172 metal binding site [ion binding]; metal-binding site 590998004173 active site 590998004174 I-site; other site 590998004175 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 590998004176 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 590998004177 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 590998004178 putative active site [active] 590998004179 putative metal binding site [ion binding]; other site 590998004180 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 590998004181 Competence-damaged protein; Region: CinA; pfam02464 590998004182 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 590998004183 non-specific DNA binding site [nucleotide binding]; other site 590998004184 salt bridge; other site 590998004185 sequence-specific DNA binding site [nucleotide binding]; other site 590998004186 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 590998004187 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 590998004188 putative DNA binding site [nucleotide binding]; other site 590998004189 catalytic residue [active] 590998004190 putative H2TH interface [polypeptide binding]; other site 590998004191 putative catalytic residues [active] 590998004192 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 590998004193 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 590998004194 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 590998004195 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 590998004196 ATP binding site [chemical binding]; other site 590998004197 putative Mg++ binding site [ion binding]; other site 590998004198 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 590998004199 nucleotide binding region [chemical binding]; other site 590998004200 ATP-binding site [chemical binding]; other site 590998004201 DEAD/H associated; Region: DEAD_assoc; pfam08494 590998004202 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 590998004203 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 590998004204 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 590998004205 recombinase A; Provisional; Region: recA; PRK09354 590998004206 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 590998004207 hexamer interface [polypeptide binding]; other site 590998004208 Walker A motif; other site 590998004209 ATP binding site [chemical binding]; other site 590998004210 Walker B motif; other site 590998004211 recombination regulator RecX; Reviewed; Region: recX; PRK00117 590998004212 phosphodiesterase; Provisional; Region: PRK12704 590998004213 KH domain; Region: KH_1; pfam00013 590998004214 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 590998004215 Zn2+ binding site [ion binding]; other site 590998004216 Mg2+ binding site [ion binding]; other site 590998004217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998004218 dimer interface [polypeptide binding]; other site 590998004219 conserved gate region; other site 590998004220 putative PBP binding loops; other site 590998004221 ABC-ATPase subunit interface; other site 590998004222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998004223 dimer interface [polypeptide binding]; other site 590998004224 conserved gate region; other site 590998004225 ABC-ATPase subunit interface; other site 590998004226 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 590998004227 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 590998004228 substrate binding pocket [chemical binding]; other site 590998004229 membrane-bound complex binding site; other site 590998004230 hinge residues; other site 590998004231 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 590998004232 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 590998004233 Walker A/P-loop; other site 590998004234 ATP binding site [chemical binding]; other site 590998004235 Q-loop/lid; other site 590998004236 ABC transporter signature motif; other site 590998004237 Walker B; other site 590998004238 D-loop; other site 590998004239 H-loop/switch region; other site 590998004240 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 590998004241 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 590998004242 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 590998004243 FeS/SAM binding site; other site 590998004244 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 590998004245 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 590998004246 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 590998004247 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 590998004248 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 590998004249 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 590998004250 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 590998004251 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 590998004252 catalytic residues [active] 590998004253 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 590998004254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998004255 S-adenosylmethionine binding site [chemical binding]; other site 590998004256 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 590998004257 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 590998004258 HflX GTPase family; Region: HflX; cd01878 590998004259 G1 box; other site 590998004260 GTP/Mg2+ binding site [chemical binding]; other site 590998004261 Switch I region; other site 590998004262 G2 box; other site 590998004263 G3 box; other site 590998004264 Switch II region; other site 590998004265 G4 box; other site 590998004266 G5 box; other site 590998004267 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 590998004268 DEAD/DEAH box helicase; Region: DEAD; pfam00270 590998004269 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 590998004270 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 590998004271 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 590998004272 NAD(P) binding site [chemical binding]; other site 590998004273 LDH/MDH dimer interface [polypeptide binding]; other site 590998004274 substrate binding site [chemical binding]; other site 590998004275 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 590998004276 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 590998004277 LexA repressor; Validated; Region: PRK00215 590998004278 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 590998004279 Catalytic site [active] 590998004280 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 590998004281 ATP cone domain; Region: ATP-cone; pfam03477 590998004282 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 590998004283 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 590998004284 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 590998004285 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 590998004286 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 590998004287 ligand binding site [chemical binding]; other site 590998004288 NAD binding site [chemical binding]; other site 590998004289 tetramer interface [polypeptide binding]; other site 590998004290 catalytic site [active] 590998004291 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 590998004292 L-serine binding site [chemical binding]; other site 590998004293 ACT domain interface; other site 590998004294 Part of AAA domain; Region: AAA_19; pfam13245 590998004295 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 590998004296 CHASE3 domain; Region: CHASE3; pfam05227 590998004297 HAMP domain; Region: HAMP; pfam00672 590998004298 dimerization interface [polypeptide binding]; other site 590998004299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 590998004300 dimer interface [polypeptide binding]; other site 590998004301 phosphorylation site [posttranslational modification] 590998004302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998004303 ATP binding site [chemical binding]; other site 590998004304 Mg2+ binding site [ion binding]; other site 590998004305 G-X-G motif; other site 590998004306 Response regulator receiver domain; Region: Response_reg; pfam00072 590998004307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998004308 active site 590998004309 phosphorylation site [posttranslational modification] 590998004310 intermolecular recognition site; other site 590998004311 dimerization interface [polypeptide binding]; other site 590998004312 PAC2 family; Region: PAC2; pfam09754 590998004313 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 590998004314 DNA-binding site [nucleotide binding]; DNA binding site 590998004315 RNA-binding motif; other site 590998004316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998004317 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 590998004318 active site 590998004319 DNA polymerase IV; Validated; Region: PRK02406 590998004320 DNA binding site [nucleotide binding] 590998004321 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 590998004322 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 590998004323 Protein of unknown function DUF58; Region: DUF58; pfam01882 590998004324 MoxR-like ATPases [General function prediction only]; Region: COG0714 590998004325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 590998004326 ATP binding site [chemical binding]; other site 590998004327 Walker A motif; other site 590998004328 Walker B motif; other site 590998004329 arginine finger; other site 590998004330 cell division protein MraZ; Reviewed; Region: PRK00326 590998004331 MraZ protein; Region: MraZ; pfam02381 590998004332 MraZ protein; Region: MraZ; pfam02381 590998004333 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 590998004334 MraW methylase family; Region: Methyltransf_5; cl17771 590998004335 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 590998004336 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 590998004337 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 590998004338 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 590998004339 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 590998004340 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 590998004341 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 590998004342 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 590998004343 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 590998004344 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 590998004345 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 590998004346 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 590998004347 Mg++ binding site [ion binding]; other site 590998004348 putative catalytic motif [active] 590998004349 putative substrate binding site [chemical binding]; other site 590998004350 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 590998004351 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 590998004352 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 590998004353 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 590998004354 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 590998004355 homodimer interface [polypeptide binding]; other site 590998004356 active site 590998004357 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 590998004358 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 590998004359 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 590998004360 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 590998004361 Cell division protein FtsQ; Region: FtsQ; pfam03799 590998004362 cell division protein FtsZ; Validated; Region: PRK09330 590998004363 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 590998004364 nucleotide binding site [chemical binding]; other site 590998004365 SulA interaction site; other site 590998004366 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 590998004367 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 590998004368 Protein of unknown function (DUF552); Region: DUF552; pfam04472 590998004369 YGGT family; Region: YGGT; cl00508 590998004370 DivIVA protein; Region: DivIVA; pfam05103 590998004371 DivIVA domain; Region: DivI1A_domain; TIGR03544 590998004372 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 590998004373 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 590998004374 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 590998004375 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 590998004376 active site 590998004377 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 590998004378 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 590998004379 active site 590998004380 PHP Thumb interface [polypeptide binding]; other site 590998004381 metal binding site [ion binding]; metal-binding site 590998004382 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 590998004383 generic binding surface II; other site 590998004384 generic binding surface I; other site 590998004385 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998004386 putative DNA binding site [nucleotide binding]; other site 590998004387 dimerization interface [polypeptide binding]; other site 590998004388 putative Zn2+ binding site [ion binding]; other site 590998004389 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 590998004390 putative hydrophobic ligand binding site [chemical binding]; other site 590998004391 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 590998004392 RNA binding surface [nucleotide binding]; other site 590998004393 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 590998004394 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 590998004395 NAD binding site [chemical binding]; other site 590998004396 dimerization interface [polypeptide binding]; other site 590998004397 product binding site; other site 590998004398 substrate binding site [chemical binding]; other site 590998004399 zinc binding site [ion binding]; other site 590998004400 catalytic residues [active] 590998004401 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 590998004402 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 590998004403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998004404 homodimer interface [polypeptide binding]; other site 590998004405 catalytic residue [active] 590998004406 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 590998004407 putative active site pocket [active] 590998004408 4-fold oligomerization interface [polypeptide binding]; other site 590998004409 metal binding residues [ion binding]; metal-binding site 590998004410 3-fold/trimer interface [polypeptide binding]; other site 590998004411 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 590998004412 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 590998004413 putative active site [active] 590998004414 oxyanion strand; other site 590998004415 catalytic triad [active] 590998004416 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 590998004417 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 590998004418 catalytic residues [active] 590998004419 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 590998004420 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 590998004421 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 590998004422 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 590998004423 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 590998004424 tetramer interface [polypeptide binding]; other site 590998004425 heme binding pocket [chemical binding]; other site 590998004426 NADPH binding site [chemical binding]; other site 590998004427 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 590998004428 metal binding site 2 [ion binding]; metal-binding site 590998004429 putative DNA binding helix; other site 590998004430 metal binding site 1 [ion binding]; metal-binding site 590998004431 dimer interface [polypeptide binding]; other site 590998004432 structural Zn2+ binding site [ion binding]; other site 590998004433 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 590998004434 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 590998004435 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 590998004436 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 590998004437 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 590998004438 23S rRNA binding site [nucleotide binding]; other site 590998004439 L21 binding site [polypeptide binding]; other site 590998004440 L13 binding site [polypeptide binding]; other site 590998004441 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 590998004442 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 590998004443 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 590998004444 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 590998004445 RDD family; Region: RDD; pfam06271 590998004446 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 590998004447 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 590998004448 dimer interface [polypeptide binding]; other site 590998004449 motif 1; other site 590998004450 active site 590998004451 motif 2; other site 590998004452 motif 3; other site 590998004453 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 590998004454 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 590998004455 putative tRNA-binding site [nucleotide binding]; other site 590998004456 B3/4 domain; Region: B3_4; pfam03483 590998004457 tRNA synthetase B5 domain; Region: B5; pfam03484 590998004458 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 590998004459 dimer interface [polypeptide binding]; other site 590998004460 motif 1; other site 590998004461 motif 3; other site 590998004462 motif 2; other site 590998004463 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 590998004464 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 590998004465 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 590998004466 generic binding surface I; other site 590998004467 generic binding surface II; other site 590998004468 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 590998004469 putative active site [active] 590998004470 putative catalytic site [active] 590998004471 putative Mg binding site IVb [ion binding]; other site 590998004472 putative phosphate binding site [ion binding]; other site 590998004473 putative DNA binding site [nucleotide binding]; other site 590998004474 putative Mg binding site IVa [ion binding]; other site 590998004475 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 590998004476 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 590998004477 active site 590998004478 metal binding site [ion binding]; metal-binding site 590998004479 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 590998004480 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 590998004481 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 590998004482 active site 590998004483 thiamine phosphate binding site [chemical binding]; other site 590998004484 pyrophosphate binding site [ion binding]; other site 590998004485 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 590998004486 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 590998004487 dimer interface [polypeptide binding]; other site 590998004488 substrate binding site [chemical binding]; other site 590998004489 ATP binding site [chemical binding]; other site 590998004490 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 590998004491 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 590998004492 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 590998004493 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 590998004494 catalytic residue [active] 590998004495 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 590998004496 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 590998004497 catalytic residues [active] 590998004498 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 590998004499 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 590998004500 NADP binding site [chemical binding]; other site 590998004501 dimer interface [polypeptide binding]; other site 590998004502 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 590998004503 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 590998004504 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 590998004505 heterotetramer interface [polypeptide binding]; other site 590998004506 active site pocket [active] 590998004507 cleavage site 590998004508 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 590998004509 feedback inhibition sensing region; other site 590998004510 homohexameric interface [polypeptide binding]; other site 590998004511 nucleotide binding site [chemical binding]; other site 590998004512 N-acetyl-L-glutamate binding site [chemical binding]; other site 590998004513 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 590998004514 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 590998004515 inhibitor-cofactor binding pocket; inhibition site 590998004516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998004517 catalytic residue [active] 590998004518 ornithine carbamoyltransferase; Provisional; Region: PRK00779 590998004519 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 590998004520 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 590998004521 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 590998004522 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 590998004523 argininosuccinate synthase; Provisional; Region: PRK13820 590998004524 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 590998004525 ANP binding site [chemical binding]; other site 590998004526 Substrate Binding Site II [chemical binding]; other site 590998004527 Substrate Binding Site I [chemical binding]; other site 590998004528 argininosuccinate lyase; Provisional; Region: PRK00855 590998004529 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 590998004530 active sites [active] 590998004531 tetramer interface [polypeptide binding]; other site 590998004532 hypothetical protein; Provisional; Region: PRK06547 590998004533 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 590998004534 active site 590998004535 DNA binding site [nucleotide binding] 590998004536 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 590998004537 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 590998004538 active site 590998004539 HIGH motif; other site 590998004540 dimer interface [polypeptide binding]; other site 590998004541 KMSKS motif; other site 590998004542 tetratricopeptide repeat protein; Provisional; Region: PRK11788 590998004543 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 590998004544 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 590998004545 active site 590998004546 motif I; other site 590998004547 motif II; other site 590998004548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 590998004549 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 590998004550 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 590998004551 RNA binding surface [nucleotide binding]; other site 590998004552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998004553 S-adenosylmethionine binding site [chemical binding]; other site 590998004554 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 590998004555 ATP-NAD kinase; Region: NAD_kinase; pfam01513 590998004556 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 590998004557 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 590998004558 Walker A/P-loop; other site 590998004559 ATP binding site [chemical binding]; other site 590998004560 Q-loop/lid; other site 590998004561 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 590998004562 ABC transporter signature motif; other site 590998004563 Walker B; other site 590998004564 D-loop; other site 590998004565 H-loop/switch region; other site 590998004566 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 590998004567 Thiamine pyrophosphokinase; Region: TPK; cl08415 590998004568 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 590998004569 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 590998004570 CTP synthetase; Validated; Region: pyrG; PRK05380 590998004571 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 590998004572 Catalytic site [active] 590998004573 active site 590998004574 UTP binding site [chemical binding]; other site 590998004575 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 590998004576 active site 590998004577 putative oxyanion hole; other site 590998004578 catalytic triad [active] 590998004579 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 590998004580 dimer interface [polypeptide binding]; other site 590998004581 ADP-ribose binding site [chemical binding]; other site 590998004582 active site 590998004583 nudix motif; other site 590998004584 metal binding site [ion binding]; metal-binding site 590998004585 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 590998004586 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 590998004587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998004588 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 590998004589 Walker A/P-loop; other site 590998004590 ATP binding site [chemical binding]; other site 590998004591 Q-loop/lid; other site 590998004592 ABC transporter signature motif; other site 590998004593 Walker B; other site 590998004594 D-loop; other site 590998004595 H-loop/switch region; other site 590998004596 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 590998004597 Predicted ATPase [General function prediction only]; Region: COG3903 590998004598 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 590998004599 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 590998004600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998004601 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 590998004602 Walker A/P-loop; other site 590998004603 ATP binding site [chemical binding]; other site 590998004604 Q-loop/lid; other site 590998004605 ABC transporter signature motif; other site 590998004606 Walker B; other site 590998004607 D-loop; other site 590998004608 H-loop/switch region; other site 590998004609 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 590998004610 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 590998004611 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 590998004612 Walker A/P-loop; other site 590998004613 ATP binding site [chemical binding]; other site 590998004614 Q-loop/lid; other site 590998004615 ABC transporter signature motif; other site 590998004616 Walker B; other site 590998004617 D-loop; other site 590998004618 H-loop/switch region; other site 590998004619 Predicted transcriptional regulator [Transcription]; Region: COG2345 590998004620 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998004621 putative DNA binding site [nucleotide binding]; other site 590998004622 putative Zn2+ binding site [ion binding]; other site 590998004623 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 590998004624 FeS assembly protein SufB; Region: sufB; TIGR01980 590998004625 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 590998004626 FeS assembly protein SufD; Region: sufD; TIGR01981 590998004627 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 590998004628 [2Fe-2S] cluster binding site [ion binding]; other site 590998004629 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 590998004630 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 590998004631 Walker A/P-loop; other site 590998004632 ATP binding site [chemical binding]; other site 590998004633 Q-loop/lid; other site 590998004634 ABC transporter signature motif; other site 590998004635 Walker B; other site 590998004636 D-loop; other site 590998004637 H-loop/switch region; other site 590998004638 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 590998004639 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 590998004640 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 590998004641 catalytic residue [active] 590998004642 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 590998004643 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 590998004644 trimerization site [polypeptide binding]; other site 590998004645 active site 590998004646 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 590998004647 Predicted transcriptional regulators [Transcription]; Region: COG1695 590998004648 Transcriptional regulator PadR-like family; Region: PadR; cl17335 590998004649 Protein of unknown function (DUF664); Region: DUF664; pfam04978 590998004650 DinB superfamily; Region: DinB_2; pfam12867 590998004651 Predicted acetyltransferase [General function prediction only]; Region: COG3153 590998004652 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998004653 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998004654 DNA binding site [nucleotide binding] 590998004655 domain linker motif; other site 590998004656 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 590998004657 putative ligand binding site [chemical binding]; other site 590998004658 putative dimerization interface [polypeptide binding]; other site 590998004659 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 590998004660 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 590998004661 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 590998004662 Immunoglobulin domain; Region: Ig; cl11960 590998004663 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 590998004664 Cobalt transport protein; Region: CbiQ; cl00463 590998004665 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 590998004666 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 590998004667 Walker A/P-loop; other site 590998004668 ATP binding site [chemical binding]; other site 590998004669 Q-loop/lid; other site 590998004670 ABC transporter signature motif; other site 590998004671 Walker B; other site 590998004672 D-loop; other site 590998004673 H-loop/switch region; other site 590998004674 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 590998004675 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 590998004676 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 590998004677 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 590998004678 ABC transporter; Region: ABC_tran_2; pfam12848 590998004679 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 590998004680 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 590998004681 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 590998004682 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 590998004683 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 590998004684 NAD(P) binding site [chemical binding]; other site 590998004685 homotetramer interface [polypeptide binding]; other site 590998004686 homodimer interface [polypeptide binding]; other site 590998004687 active site 590998004688 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 590998004689 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 590998004690 NAD binding site [chemical binding]; other site 590998004691 homotetramer interface [polypeptide binding]; other site 590998004692 homodimer interface [polypeptide binding]; other site 590998004693 substrate binding site [chemical binding]; other site 590998004694 active site 590998004695 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 590998004696 catalytic core [active] 590998004697 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 590998004698 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 590998004699 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 590998004700 motif II; other site 590998004701 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 590998004702 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 590998004703 ligand binding site; other site 590998004704 oligomer interface; other site 590998004705 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 590998004706 dimer interface [polypeptide binding]; other site 590998004707 N-terminal domain interface [polypeptide binding]; other site 590998004708 sulfate 1 binding site; other site 590998004709 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 590998004710 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 590998004711 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 590998004712 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998004713 Walker A/P-loop; other site 590998004714 ATP binding site [chemical binding]; other site 590998004715 Q-loop/lid; other site 590998004716 ABC transporter signature motif; other site 590998004717 Walker B; other site 590998004718 D-loop; other site 590998004719 H-loop/switch region; other site 590998004720 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 590998004721 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 590998004722 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 590998004723 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 590998004724 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 590998004725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998004726 Walker A/P-loop; other site 590998004727 ATP binding site [chemical binding]; other site 590998004728 Q-loop/lid; other site 590998004729 ABC transporter signature motif; other site 590998004730 Walker B; other site 590998004731 D-loop; other site 590998004732 H-loop/switch region; other site 590998004733 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 590998004734 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 590998004735 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 590998004736 Walker A/P-loop; other site 590998004737 ATP binding site [chemical binding]; other site 590998004738 Q-loop/lid; other site 590998004739 ABC transporter signature motif; other site 590998004740 Walker B; other site 590998004741 D-loop; other site 590998004742 H-loop/switch region; other site 590998004743 oxidoreductase; Provisional; Region: PRK06128 590998004744 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 590998004745 NAD binding site [chemical binding]; other site 590998004746 metal binding site [ion binding]; metal-binding site 590998004747 active site 590998004748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998004749 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 590998004750 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 590998004751 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 590998004752 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 590998004753 Repair protein; Region: Repair_PSII; pfam04536 590998004754 Methyltransferase domain; Region: Methyltransf_31; pfam13847 590998004755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998004756 S-adenosylmethionine binding site [chemical binding]; other site 590998004757 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 590998004758 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 590998004759 DNA binding site [nucleotide binding] 590998004760 Predicted ATPase [General function prediction only]; Region: COG3903 590998004761 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 590998004762 putative deacylase active site [active] 590998004763 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 590998004764 substrate binding site [chemical binding]; other site 590998004765 DNA Polymerase Y-family; Region: PolY_like; cd03468 590998004766 active site 590998004767 DNA binding site [nucleotide binding] 590998004768 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 590998004769 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 590998004770 active site 590998004771 PHP Thumb interface [polypeptide binding]; other site 590998004772 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 590998004773 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 590998004774 generic binding surface I; other site 590998004775 generic binding surface II; other site 590998004776 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 590998004777 inhibitor site; inhibition site 590998004778 active site 590998004779 dimer interface [polypeptide binding]; other site 590998004780 catalytic residue [active] 590998004781 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 590998004782 Domain of unknown function DUF20; Region: UPF0118; pfam01594 590998004783 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 590998004784 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 590998004785 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 590998004786 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 590998004787 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 590998004788 active site 590998004789 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 590998004790 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 590998004791 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998004792 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998004793 DNA binding site [nucleotide binding] 590998004794 domain linker motif; other site 590998004795 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998004796 dimerization interface [polypeptide binding]; other site 590998004797 ligand binding site [chemical binding]; other site 590998004798 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998004799 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 590998004800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998004801 dimer interface [polypeptide binding]; other site 590998004802 conserved gate region; other site 590998004803 putative PBP binding loops; other site 590998004804 ABC-ATPase subunit interface; other site 590998004805 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998004806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998004807 dimer interface [polypeptide binding]; other site 590998004808 conserved gate region; other site 590998004809 ABC-ATPase subunit interface; other site 590998004810 Right handed beta helix region; Region: Beta_helix; pfam13229 590998004811 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 590998004812 active site 590998004813 catalytic triad [active] 590998004814 oxyanion hole [active] 590998004815 Cellulose binding domain; Region: CBM_2; pfam00553 590998004816 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 590998004817 THUMP domain, predicted to bind RNA; Region: THUMP; cl12076 590998004818 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 590998004819 P-loop containing region of AAA domain; Region: AAA_29; cl17516 590998004820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 590998004821 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 590998004822 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 590998004823 PAS fold; Region: PAS_3; pfam08447 590998004824 putative active site [active] 590998004825 heme pocket [chemical binding]; other site 590998004826 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 590998004827 dimer interface [polypeptide binding]; other site 590998004828 putative CheW interface [polypeptide binding]; other site 590998004829 Methyltransferase domain; Region: Methyltransf_23; pfam13489 590998004830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998004831 S-adenosylmethionine binding site [chemical binding]; other site 590998004832 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 590998004833 Protein of unknown function (DUF419); Region: DUF419; cl15265 590998004834 amino acid transporter; Region: 2A0306; TIGR00909 590998004835 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 590998004836 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 590998004837 Ligand Binding Site [chemical binding]; other site 590998004838 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 590998004839 Ligand Binding Site [chemical binding]; other site 590998004840 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 590998004841 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 590998004842 active site 590998004843 DNA binding site [nucleotide binding] 590998004844 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 590998004845 DNA binding site [nucleotide binding] 590998004846 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 590998004847 active site 590998004848 Fructosamine kinase; Region: Fructosamin_kin; cl17579 590998004849 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 590998004850 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 590998004851 hexamer interface [polypeptide binding]; other site 590998004852 ligand binding site [chemical binding]; other site 590998004853 putative active site [active] 590998004854 NAD(P) binding site [chemical binding]; other site 590998004855 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 590998004856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998004857 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 590998004858 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 590998004859 active site 590998004860 Zn binding site [ion binding]; other site 590998004861 hypothetical protein; Provisional; Region: PRK07906 590998004862 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 590998004863 putative metal binding site [ion binding]; other site 590998004864 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 590998004865 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 590998004866 active site 590998004867 catalytic tetrad [active] 590998004868 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 590998004869 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 590998004870 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 590998004871 oligomer interface [polypeptide binding]; other site 590998004872 putative Cl binding site [ion binding]; other site 590998004873 basic sphincter; other site 590998004874 hydrophobic gate; other site 590998004875 periplasmic entrance; other site 590998004876 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 590998004877 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 590998004878 active site 590998004879 HIGH motif; other site 590998004880 nucleotide binding site [chemical binding]; other site 590998004881 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 590998004882 active site 590998004883 KMSKS motif; other site 590998004884 PAC2 family; Region: PAC2; pfam09754 590998004885 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 590998004886 dimerization interface [polypeptide binding]; other site 590998004887 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 590998004888 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 590998004889 dimer interface [polypeptide binding]; other site 590998004890 putative CheW interface [polypeptide binding]; other site 590998004891 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 590998004892 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 590998004893 putative ligand binding site [chemical binding]; other site 590998004894 Fic family protein [Function unknown]; Region: COG3177 590998004895 Fic/DOC family; Region: Fic; pfam02661 590998004896 HTH DNA binding domain; Region: HTH_13; pfam11972 590998004897 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 590998004898 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 590998004899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 590998004900 motif II; other site 590998004901 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 590998004902 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 590998004903 active site 590998004904 Peptidase family M50; Region: Peptidase_M50; pfam02163 590998004905 putative substrate binding region [chemical binding]; other site 590998004906 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 590998004907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998004908 S-adenosylmethionine binding site [chemical binding]; other site 590998004909 proteasome ATPase; Region: pup_AAA; TIGR03689 590998004910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 590998004911 Walker A motif; other site 590998004912 ATP binding site [chemical binding]; other site 590998004913 Walker B motif; other site 590998004914 arginine finger; other site 590998004915 Pup-ligase protein; Region: Pup_ligase; cl15463 590998004916 Pup-like protein; Region: Pup; pfam05639 590998004917 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 590998004918 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 590998004919 active site 590998004920 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 590998004921 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 590998004922 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 590998004923 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 590998004924 substrate binding site [chemical binding]; other site 590998004925 glutamase interaction surface [polypeptide binding]; other site 590998004926 TIGR03085 family protein; Region: TIGR03085 590998004927 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 590998004928 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 590998004929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998004930 Walker A/P-loop; other site 590998004931 ATP binding site [chemical binding]; other site 590998004932 Q-loop/lid; other site 590998004933 ABC transporter signature motif; other site 590998004934 Walker B; other site 590998004935 D-loop; other site 590998004936 H-loop/switch region; other site 590998004937 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 590998004938 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998004939 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 590998004940 Walker A/P-loop; other site 590998004941 ATP binding site [chemical binding]; other site 590998004942 Q-loop/lid; other site 590998004943 ABC transporter signature motif; other site 590998004944 Walker B; other site 590998004945 D-loop; other site 590998004946 H-loop/switch region; other site 590998004947 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 590998004948 anthranilate synthase component I; Provisional; Region: PRK13571 590998004949 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 590998004950 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 590998004951 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 590998004952 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 590998004953 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 590998004954 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 590998004955 active site 590998004956 ribulose/triose binding site [chemical binding]; other site 590998004957 phosphate binding site [ion binding]; other site 590998004958 substrate (anthranilate) binding pocket [chemical binding]; other site 590998004959 product (indole) binding pocket [chemical binding]; other site 590998004960 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 590998004961 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 590998004962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998004963 catalytic residue [active] 590998004964 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 590998004965 substrate binding site [chemical binding]; other site 590998004966 active site 590998004967 catalytic residues [active] 590998004968 heterodimer interface [polypeptide binding]; other site 590998004969 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 590998004970 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 590998004971 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 590998004972 active site 590998004973 dimer interface [polypeptide binding]; other site 590998004974 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 590998004975 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 590998004976 active site 590998004977 FMN binding site [chemical binding]; other site 590998004978 substrate binding site [chemical binding]; other site 590998004979 3Fe-4S cluster binding site [ion binding]; other site 590998004980 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 590998004981 domain interface; other site 590998004982 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 590998004983 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 590998004984 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 590998004985 pyruvate kinase; Provisional; Region: PRK06247 590998004986 domain interfaces; other site 590998004987 active site 590998004988 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 590998004989 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 590998004990 Caspase domain; Region: Peptidase_C14; pfam00656 590998004991 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 590998004992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 590998004993 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998004994 Coenzyme A binding pocket [chemical binding]; other site 590998004995 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 590998004996 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 590998004997 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998004998 NAD(P) binding site [chemical binding]; other site 590998004999 active site 590998005000 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 590998005001 Ligand Binding Site [chemical binding]; other site 590998005002 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 590998005003 Ligand Binding Site [chemical binding]; other site 590998005004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998005005 S-adenosylmethionine binding site [chemical binding]; other site 590998005006 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 590998005007 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 590998005008 Haemolytic domain; Region: Haemolytic; cl00506 590998005009 Domain of unknown function (DUF385); Region: DUF385; cl04387 590998005010 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 590998005011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998005012 Response regulator receiver domain; Region: Response_reg; pfam00072 590998005013 active site 590998005014 phosphorylation site [posttranslational modification] 590998005015 intermolecular recognition site; other site 590998005016 dimerization interface [polypeptide binding]; other site 590998005017 ANTAR domain; Region: ANTAR; pfam03861 590998005018 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 590998005019 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 590998005020 ligand binding site [chemical binding]; other site 590998005021 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 590998005022 putative catalytic site [active] 590998005023 putative phosphate binding site [ion binding]; other site 590998005024 putative metal binding site [ion binding]; other site 590998005025 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 590998005026 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 590998005027 Walker A/P-loop; other site 590998005028 ATP binding site [chemical binding]; other site 590998005029 Q-loop/lid; other site 590998005030 ABC transporter signature motif; other site 590998005031 Walker B; other site 590998005032 D-loop; other site 590998005033 H-loop/switch region; other site 590998005034 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 590998005035 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 590998005036 Walker A/P-loop; other site 590998005037 ATP binding site [chemical binding]; other site 590998005038 Q-loop/lid; other site 590998005039 ABC transporter signature motif; other site 590998005040 Walker B; other site 590998005041 D-loop; other site 590998005042 H-loop/switch region; other site 590998005043 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 590998005044 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 590998005045 TM-ABC transporter signature motif; other site 590998005046 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 590998005047 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 590998005048 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 590998005049 TM-ABC transporter signature motif; other site 590998005050 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 590998005051 CoenzymeA binding site [chemical binding]; other site 590998005052 subunit interaction site [polypeptide binding]; other site 590998005053 PHB binding site; other site 590998005054 DNA polymerase I; Provisional; Region: PRK05755 590998005055 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 590998005056 active site 590998005057 metal binding site 1 [ion binding]; metal-binding site 590998005058 putative 5' ssDNA interaction site; other site 590998005059 metal binding site 3; metal-binding site 590998005060 metal binding site 2 [ion binding]; metal-binding site 590998005061 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 590998005062 putative DNA binding site [nucleotide binding]; other site 590998005063 putative metal binding site [ion binding]; other site 590998005064 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 590998005065 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 590998005066 active site 590998005067 DNA binding site [nucleotide binding] 590998005068 catalytic site [active] 590998005069 Protein of unknown function, DUF485; Region: DUF485; pfam04341 590998005070 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 590998005071 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 590998005072 Na binding site [ion binding]; other site 590998005073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998005074 S-adenosylmethionine binding site [chemical binding]; other site 590998005075 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 590998005076 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 590998005077 peptide binding site [polypeptide binding]; other site 590998005078 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 590998005079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998005080 ABC-ATPase subunit interface; other site 590998005081 putative PBP binding loops; other site 590998005082 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 590998005083 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 590998005084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998005085 ABC-ATPase subunit interface; other site 590998005086 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 590998005087 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 590998005088 Walker A/P-loop; other site 590998005089 ATP binding site [chemical binding]; other site 590998005090 Q-loop/lid; other site 590998005091 ABC transporter signature motif; other site 590998005092 Walker B; other site 590998005093 D-loop; other site 590998005094 H-loop/switch region; other site 590998005095 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 590998005096 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 590998005097 Walker A/P-loop; other site 590998005098 ATP binding site [chemical binding]; other site 590998005099 Q-loop/lid; other site 590998005100 ABC transporter signature motif; other site 590998005101 Walker B; other site 590998005102 D-loop; other site 590998005103 H-loop/switch region; other site 590998005104 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 590998005105 6-phosphofructokinase; Provisional; Region: PRK03202 590998005106 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 590998005107 active site 590998005108 ADP/pyrophosphate binding site [chemical binding]; other site 590998005109 dimerization interface [polypeptide binding]; other site 590998005110 allosteric effector site; other site 590998005111 fructose-1,6-bisphosphate binding site; other site 590998005112 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 590998005113 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 590998005114 RNA binding site [nucleotide binding]; other site 590998005115 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 590998005116 RNA binding site [nucleotide binding]; other site 590998005117 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 590998005118 RNA binding site [nucleotide binding]; other site 590998005119 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 590998005120 RNA binding site [nucleotide binding]; other site 590998005121 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 590998005122 CoA-binding site [chemical binding]; other site 590998005123 ATP-binding [chemical binding]; other site 590998005124 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 590998005125 putative substrate binding pocket [chemical binding]; other site 590998005126 AC domain interface; other site 590998005127 catalytic triad [active] 590998005128 AB domain interface; other site 590998005129 interchain disulfide; other site 590998005130 excinuclease ABC subunit B; Provisional; Region: PRK05298 590998005131 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 590998005132 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 590998005133 nucleotide binding region [chemical binding]; other site 590998005134 ATP-binding site [chemical binding]; other site 590998005135 Ultra-violet resistance protein B; Region: UvrB; pfam12344 590998005136 UvrB/uvrC motif; Region: UVR; pfam02151 590998005137 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 590998005138 YCII-related domain; Region: YCII; cl00999 590998005139 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 590998005140 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 590998005141 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 590998005142 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 590998005143 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 590998005144 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 590998005145 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 590998005146 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 590998005147 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 590998005148 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 590998005149 OsmC-like protein; Region: OsmC; cl00767 590998005150 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 590998005151 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 590998005152 GIY-YIG motif/motif A; other site 590998005153 active site 590998005154 catalytic site [active] 590998005155 putative DNA binding site [nucleotide binding]; other site 590998005156 metal binding site [ion binding]; metal-binding site 590998005157 UvrB/uvrC motif; Region: UVR; pfam02151 590998005158 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 590998005159 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 590998005160 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 590998005161 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 590998005162 phosphate binding site [ion binding]; other site 590998005163 putative substrate binding pocket [chemical binding]; other site 590998005164 dimer interface [polypeptide binding]; other site 590998005165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 590998005166 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 590998005167 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 590998005168 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 590998005169 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 590998005170 Phosphoglycerate kinase; Region: PGK; pfam00162 590998005171 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 590998005172 substrate binding site [chemical binding]; other site 590998005173 hinge regions; other site 590998005174 ADP binding site [chemical binding]; other site 590998005175 catalytic site [active] 590998005176 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 590998005177 triosephosphate isomerase; Provisional; Region: PRK14567 590998005178 substrate binding site [chemical binding]; other site 590998005179 dimer interface [polypeptide binding]; other site 590998005180 catalytic triad [active] 590998005181 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 590998005182 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 590998005183 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 590998005184 putative active site [active] 590998005185 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 590998005186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998005187 S-adenosylmethionine binding site [chemical binding]; other site 590998005188 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 590998005189 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 590998005190 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 590998005191 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 590998005192 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 590998005193 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 590998005194 putative active site [active] 590998005195 transaldolase; Provisional; Region: PRK03903 590998005196 catalytic residue [active] 590998005197 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 590998005198 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 590998005199 TPP-binding site [chemical binding]; other site 590998005200 dimer interface [polypeptide binding]; other site 590998005201 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 590998005202 PYR/PP interface [polypeptide binding]; other site 590998005203 dimer interface [polypeptide binding]; other site 590998005204 TPP binding site [chemical binding]; other site 590998005205 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 590998005206 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 590998005207 UbiA prenyltransferase family; Region: UbiA; pfam01040 590998005208 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 590998005209 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 590998005210 active site 590998005211 DNA binding site [nucleotide binding] 590998005212 Int/Topo IB signature motif; other site 590998005213 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 590998005214 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 590998005215 P-loop; other site 590998005216 Magnesium ion binding site [ion binding]; other site 590998005217 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 590998005218 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 590998005219 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 590998005220 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 590998005221 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 590998005222 RNA binding surface [nucleotide binding]; other site 590998005223 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 590998005224 active site 590998005225 prephenate dehydrogenase; Validated; Region: PRK06545 590998005226 prephenate dehydrogenase; Validated; Region: PRK08507 590998005227 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 590998005228 cytidylate kinase; Provisional; Region: cmk; PRK00023 590998005229 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 590998005230 active site 590998005231 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 590998005232 CMP-binding site; other site 590998005233 The sites determining sugar specificity; other site 590998005234 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 590998005235 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 590998005236 putative acyl-acceptor binding pocket; other site 590998005237 GTP-binding protein Der; Reviewed; Region: PRK03003 590998005238 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 590998005239 G1 box; other site 590998005240 GTP/Mg2+ binding site [chemical binding]; other site 590998005241 Switch I region; other site 590998005242 G2 box; other site 590998005243 Switch II region; other site 590998005244 G3 box; other site 590998005245 G4 box; other site 590998005246 G5 box; other site 590998005247 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 590998005248 G1 box; other site 590998005249 GTP/Mg2+ binding site [chemical binding]; other site 590998005250 Switch I region; other site 590998005251 G2 box; other site 590998005252 G3 box; other site 590998005253 Switch II region; other site 590998005254 G4 box; other site 590998005255 G5 box; other site 590998005256 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 590998005257 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 590998005258 motif II; other site 590998005259 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 590998005260 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 590998005261 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 590998005262 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 590998005263 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 590998005264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 590998005265 dimerization interface [polypeptide binding]; other site 590998005266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 590998005267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 590998005268 dimer interface [polypeptide binding]; other site 590998005269 phosphorylation site [posttranslational modification] 590998005270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998005271 ATP binding site [chemical binding]; other site 590998005272 Mg2+ binding site [ion binding]; other site 590998005273 G-X-G motif; other site 590998005274 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 590998005275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998005276 active site 590998005277 phosphorylation site [posttranslational modification] 590998005278 intermolecular recognition site; other site 590998005279 dimerization interface [polypeptide binding]; other site 590998005280 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 590998005281 DNA binding site [nucleotide binding] 590998005282 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 590998005283 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 590998005284 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 590998005285 Walker A/P-loop; other site 590998005286 ATP binding site [chemical binding]; other site 590998005287 Q-loop/lid; other site 590998005288 ABC transporter signature motif; other site 590998005289 Walker B; other site 590998005290 D-loop; other site 590998005291 H-loop/switch region; other site 590998005292 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 590998005293 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 590998005294 Walker A/P-loop; other site 590998005295 ATP binding site [chemical binding]; other site 590998005296 Q-loop/lid; other site 590998005297 ABC transporter signature motif; other site 590998005298 Walker B; other site 590998005299 D-loop; other site 590998005300 H-loop/switch region; other site 590998005301 potassium-tellurite ethidium and proflavin transporter; Provisional; Region: PRK10764 590998005302 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 590998005303 gating phenylalanine in ion channel; other site 590998005304 YCII-related domain; Region: YCII; cl00999 590998005305 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 590998005306 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 590998005307 active site 590998005308 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 590998005309 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 590998005310 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 590998005311 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998005312 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 590998005313 DNA binding residues [nucleotide binding] 590998005314 Putative zinc-finger; Region: zf-HC2; pfam13490 590998005315 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 590998005316 putative deacylase active site [active] 590998005317 Pirin-related protein [General function prediction only]; Region: COG1741 590998005318 Pirin; Region: Pirin; pfam02678 590998005319 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 590998005320 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 590998005321 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998005322 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 590998005323 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 590998005324 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 590998005325 DNA binding site [nucleotide binding] 590998005326 active site 590998005327 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 590998005328 malate:quinone oxidoreductase; Validated; Region: PRK05257 590998005329 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 590998005330 Cellulose binding domain; Region: CBM_2; pfam00553 590998005331 Uncharacterized conserved protein [Function unknown]; Region: COG4850 590998005332 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 590998005333 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 590998005334 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 590998005335 dimerization interface [polypeptide binding]; other site 590998005336 DPS ferroxidase diiron center [ion binding]; other site 590998005337 ion pore; other site 590998005338 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 590998005339 nucleotide binding site [chemical binding]; other site 590998005340 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 590998005341 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 590998005342 putative DNA binding site [nucleotide binding]; other site 590998005343 putative homodimer interface [polypeptide binding]; other site 590998005344 hypothetical protein; Provisional; Region: PRK07945 590998005345 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 590998005346 active site 590998005347 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 590998005348 IHF dimer interface [polypeptide binding]; other site 590998005349 IHF - DNA interface [nucleotide binding]; other site 590998005350 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 590998005351 metal binding site 2 [ion binding]; metal-binding site 590998005352 putative DNA binding helix; other site 590998005353 metal binding site 1 [ion binding]; metal-binding site 590998005354 dimer interface [polypeptide binding]; other site 590998005355 structural Zn2+ binding site [ion binding]; other site 590998005356 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 590998005357 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 590998005358 tetramer interface [polypeptide binding]; other site 590998005359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998005360 catalytic residue [active] 590998005361 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 590998005362 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 590998005363 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 590998005364 Interdomain contacts; other site 590998005365 Cytokine receptor motif; other site 590998005366 Cellulose binding domain; Region: CBM_2; pfam00553 590998005367 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 590998005368 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 590998005369 Cellulose binding domain; Region: CBM_2; pfam00553 590998005370 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998005371 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998005372 DNA binding site [nucleotide binding] 590998005373 domain linker motif; other site 590998005374 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998005375 dimerization interface [polypeptide binding]; other site 590998005376 ligand binding site [chemical binding]; other site 590998005377 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998005378 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998005379 ligand binding site [chemical binding]; other site 590998005380 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 590998005381 PAS fold; Region: PAS_3; pfam08447 590998005382 putative active site [active] 590998005383 heme pocket [chemical binding]; other site 590998005384 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 590998005385 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 590998005386 ATP binding site [chemical binding]; other site 590998005387 Mg++ binding site [ion binding]; other site 590998005388 motif III; other site 590998005389 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 590998005390 nucleotide binding region [chemical binding]; other site 590998005391 ATP-binding site [chemical binding]; other site 590998005392 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 590998005393 putative RNA binding site [nucleotide binding]; other site 590998005394 CoA binding domain; Region: CoA_binding; cl17356 590998005395 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 590998005396 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 590998005397 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 590998005398 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 590998005399 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 590998005400 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 590998005401 phosphopeptide binding site; other site 590998005402 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 590998005403 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 590998005404 DNA binding residues [nucleotide binding] 590998005405 Bifunctional nuclease; Region: DNase-RNase; pfam02577 590998005406 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 590998005407 DNA binding residues [nucleotide binding] 590998005408 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 590998005409 putative dimer interface [polypeptide binding]; other site 590998005410 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 590998005411 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 590998005412 P-loop; other site 590998005413 Magnesium ion binding site [ion binding]; other site 590998005414 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 590998005415 Magnesium ion binding site [ion binding]; other site 590998005416 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 590998005417 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 590998005418 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 590998005419 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 590998005420 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 590998005421 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 590998005422 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 590998005423 active site 590998005424 DNA binding site [nucleotide binding] 590998005425 Int/Topo IB signature motif; other site 590998005426 Domain of unknown function (DUF336); Region: DUF336; cl01249 590998005427 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 590998005428 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 590998005429 active site 590998005430 catalytic tetrad [active] 590998005431 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 590998005432 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 590998005433 Ligand binding site; other site 590998005434 Putative Catalytic site; other site 590998005435 DXD motif; other site 590998005436 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 590998005437 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 590998005438 putative active site [active] 590998005439 catalytic triad [active] 590998005440 putative dimer interface [polypeptide binding]; other site 590998005441 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 590998005442 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 590998005443 active site 590998005444 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 590998005445 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 590998005446 ATP binding site [chemical binding]; other site 590998005447 putative Mg++ binding site [ion binding]; other site 590998005448 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 590998005449 nucleotide binding region [chemical binding]; other site 590998005450 ATP-binding site [chemical binding]; other site 590998005451 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 590998005452 diacylglycerol kinase; Reviewed; Region: PRK11914 590998005453 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 590998005454 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 590998005455 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 590998005456 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 590998005457 WYL domain; Region: WYL; pfam13280 590998005458 Predicted transcriptional regulator [Transcription]; Region: COG2378 590998005459 Ribosomal protein S21e; Region: Ribosomal_S21e; pfam01249 590998005460 WYL domain; Region: WYL; pfam13280 590998005461 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 590998005462 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 590998005463 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 590998005464 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 590998005465 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 590998005466 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 590998005467 homodimer interface [polypeptide binding]; other site 590998005468 putative metal binding site [ion binding]; other site 590998005469 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 590998005470 6,7-dimethyl-8-ribityllumazine synthase; Provisional; Region: ribH; PRK00061 590998005471 homopentamer interface [polypeptide binding]; other site 590998005472 active site 590998005473 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 590998005474 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 590998005475 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 590998005476 dimerization interface [polypeptide binding]; other site 590998005477 active site 590998005478 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 590998005479 Lumazine binding domain; Region: Lum_binding; pfam00677 590998005480 Lumazine binding domain; Region: Lum_binding; pfam00677 590998005481 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 590998005482 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 590998005483 catalytic motif [active] 590998005484 Zn binding site [ion binding]; other site 590998005485 RibD C-terminal domain; Region: RibD_C; pfam01872 590998005486 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 590998005487 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 590998005488 substrate binding site [chemical binding]; other site 590998005489 hexamer interface [polypeptide binding]; other site 590998005490 metal binding site [ion binding]; metal-binding site 590998005491 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 590998005492 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 590998005493 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 590998005494 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 590998005495 putative active site [active] 590998005496 substrate binding site [chemical binding]; other site 590998005497 putative cosubstrate binding site; other site 590998005498 catalytic site [active] 590998005499 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 590998005500 substrate binding site [chemical binding]; other site 590998005501 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 590998005502 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 590998005503 motif II; other site 590998005504 primosome assembly protein PriA; Provisional; Region: PRK14873 590998005505 S-adenosylmethionine synthetase; Validated; Region: PRK05250 590998005506 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 590998005507 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 590998005508 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 590998005509 Flavoprotein; Region: Flavoprotein; pfam02441 590998005510 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 590998005511 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 590998005512 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 590998005513 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 590998005514 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 590998005515 catalytic site [active] 590998005516 G-X2-G-X-G-K; other site 590998005517 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 590998005518 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 590998005519 active site 590998005520 dimer interface [polypeptide binding]; other site 590998005521 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 590998005522 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 590998005523 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 590998005524 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 590998005525 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 590998005526 ATP-grasp domain; Region: ATP-grasp_4; cl17255 590998005527 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 590998005528 IMP binding site; other site 590998005529 dimer interface [polypeptide binding]; other site 590998005530 interdomain contacts; other site 590998005531 partial ornithine binding site; other site 590998005532 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 590998005533 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 590998005534 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 590998005535 catalytic site [active] 590998005536 subunit interface [polypeptide binding]; other site 590998005537 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 590998005538 dihydroorotase; Validated; Region: pyrC; PRK09357 590998005539 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 590998005540 active site 590998005541 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 590998005542 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 590998005543 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 590998005544 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 590998005545 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 590998005546 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 590998005547 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 590998005548 active site 590998005549 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 590998005550 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 590998005551 metal binding site [ion binding]; metal-binding site 590998005552 active site 590998005553 I-site; other site 590998005554 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 590998005555 transcription antitermination factor NusB; Region: nusB; TIGR01951 590998005556 putative RNA binding site [nucleotide binding]; other site 590998005557 elongation factor P; Validated; Region: PRK00529 590998005558 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 590998005559 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 590998005560 RNA binding site [nucleotide binding]; other site 590998005561 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 590998005562 RNA binding site [nucleotide binding]; other site 590998005563 Dehydroquinase class II; Region: DHquinase_II; pfam01220 590998005564 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 590998005565 trimer interface [polypeptide binding]; other site 590998005566 active site 590998005567 dimer interface [polypeptide binding]; other site 590998005568 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 590998005569 dimer interface [polypeptide binding]; other site 590998005570 active site 590998005571 metal binding site [ion binding]; metal-binding site 590998005572 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 590998005573 Shikimate kinase; Region: SKI; pfam01202 590998005574 ADP binding site [chemical binding]; other site 590998005575 magnesium binding site [ion binding]; other site 590998005576 putative shikimate binding site; other site 590998005577 chorismate synthase; Validated; Region: PRK05382 590998005578 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 590998005579 Tetramer interface [polypeptide binding]; other site 590998005580 active site 590998005581 FMN-binding site [chemical binding]; other site 590998005582 Pilus assembly protein, PilO; Region: PilO; cl01234 590998005583 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 590998005584 Cell division protein FtsA; Region: FtsA; cl17206 590998005585 Competence protein A; Region: Competence_A; pfam11104 590998005586 Cell division protein FtsA; Region: FtsA; pfam14450 590998005587 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 590998005588 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 590998005589 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 590998005590 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 590998005591 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 590998005592 PilX N-terminal; Region: PilX_N; pfam14341 590998005593 Verru_Chthon cassette protein C; Region: TIGR02599 590998005594 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 590998005595 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 590998005596 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 590998005597 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 590998005598 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 590998005599 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 590998005600 Walker A motif; other site 590998005601 ATP binding site [chemical binding]; other site 590998005602 Walker B motif; other site 590998005603 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 590998005604 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 590998005605 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 590998005606 Walker A motif; other site 590998005607 ATP binding site [chemical binding]; other site 590998005608 Walker B motif; other site 590998005609 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 590998005610 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 590998005611 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 590998005612 NAD(P) binding site [chemical binding]; other site 590998005613 shikimate binding site; other site 590998005614 YceG-like family; Region: YceG; pfam02618 590998005615 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 590998005616 dimerization interface [polypeptide binding]; other site 590998005617 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 590998005618 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 590998005619 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 590998005620 motif 1; other site 590998005621 active site 590998005622 motif 2; other site 590998005623 motif 3; other site 590998005624 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 590998005625 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 590998005626 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 590998005627 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 590998005628 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 590998005629 RNA binding surface [nucleotide binding]; other site 590998005630 recombination factor protein RarA; Reviewed; Region: PRK13342 590998005631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 590998005632 Walker A motif; other site 590998005633 ATP binding site [chemical binding]; other site 590998005634 Walker B motif; other site 590998005635 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 590998005636 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 590998005637 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 590998005638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998005639 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 590998005640 Coenzyme A binding pocket [chemical binding]; other site 590998005641 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 590998005642 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 590998005643 dimer interface [polypeptide binding]; other site 590998005644 anticodon binding site; other site 590998005645 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 590998005646 homodimer interface [polypeptide binding]; other site 590998005647 motif 1; other site 590998005648 active site 590998005649 motif 2; other site 590998005650 GAD domain; Region: GAD; pfam02938 590998005651 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 590998005652 active site 590998005653 motif 3; other site 590998005654 Radical SAM superfamily; Region: Radical_SAM; pfam04055 590998005655 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 590998005656 FeS/SAM binding site; other site 590998005657 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 590998005658 dimer interface [polypeptide binding]; other site 590998005659 motif 1; other site 590998005660 motif 2; other site 590998005661 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 590998005662 active site 590998005663 motif 3; other site 590998005664 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 590998005665 anticodon binding site; other site 590998005666 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 590998005667 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 590998005668 active site 590998005669 major cell surface glycoprotein; Region: halo_surf_glyco; TIGR04216 590998005670 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 590998005671 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 590998005672 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 590998005673 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 590998005674 Zn2+ binding site [ion binding]; other site 590998005675 Mg2+ binding site [ion binding]; other site 590998005676 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 590998005677 synthetase active site [active] 590998005678 NTP binding site [chemical binding]; other site 590998005679 metal binding site [ion binding]; metal-binding site 590998005680 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 590998005681 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 590998005682 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 590998005683 active site 590998005684 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 590998005685 Protein export membrane protein; Region: SecD_SecF; pfam02355 590998005686 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 590998005687 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 590998005688 Preprotein translocase subunit; Region: YajC; pfam02699 590998005689 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 590998005690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 590998005691 Walker A motif; other site 590998005692 ATP binding site [chemical binding]; other site 590998005693 Walker B motif; other site 590998005694 arginine finger; other site 590998005695 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 590998005696 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 590998005697 RuvA N terminal domain; Region: RuvA_N; pfam01330 590998005698 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 590998005699 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 590998005700 active site 590998005701 putative DNA-binding cleft [nucleotide binding]; other site 590998005702 dimer interface [polypeptide binding]; other site 590998005703 hypothetical protein; Validated; Region: PRK00110 590998005704 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 590998005705 predicted active site [active] 590998005706 catalytic triad [active] 590998005707 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 590998005708 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 590998005709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998005710 homodimer interface [polypeptide binding]; other site 590998005711 catalytic residue [active] 590998005712 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 590998005713 nudix motif; other site 590998005714 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 590998005715 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 590998005716 active site 590998005717 multimer interface [polypeptide binding]; other site 590998005718 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 590998005719 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 590998005720 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 590998005721 putative acyl-acceptor binding pocket; other site 590998005722 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 590998005723 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 590998005724 nucleotide binding site/active site [active] 590998005725 HIT family signature motif; other site 590998005726 catalytic residue [active] 590998005727 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 590998005728 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 590998005729 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 590998005730 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 590998005731 active site 590998005732 dimer interface [polypeptide binding]; other site 590998005733 motif 1; other site 590998005734 motif 2; other site 590998005735 motif 3; other site 590998005736 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 590998005737 anticodon binding site; other site 590998005738 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 590998005739 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 590998005740 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 590998005741 homodimer interface [polypeptide binding]; other site 590998005742 substrate-cofactor binding pocket; other site 590998005743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998005744 catalytic residue [active] 590998005745 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 590998005746 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 590998005747 4Fe-4S binding domain; Region: Fer4_5; pfam12801 590998005748 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 590998005749 Ycf48-like protein; Provisional; Region: PRK13684 590998005750 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 590998005751 dimerization interface [polypeptide binding]; other site 590998005752 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 590998005753 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 590998005754 metal-binding site [ion binding] 590998005755 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 590998005756 Soluble P-type ATPase [General function prediction only]; Region: COG4087 590998005757 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 590998005758 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 590998005759 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 590998005760 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 590998005761 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 590998005762 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998005763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998005764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998005765 NmrA-like family; Region: NmrA; pfam05368 590998005766 NAD(P) binding site [chemical binding]; other site 590998005767 active site 590998005768 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 590998005769 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 590998005770 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 590998005771 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998005772 Walker A/P-loop; other site 590998005773 ATP binding site [chemical binding]; other site 590998005774 Q-loop/lid; other site 590998005775 ABC transporter signature motif; other site 590998005776 Walker B; other site 590998005777 D-loop; other site 590998005778 H-loop/switch region; other site 590998005779 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 590998005780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998005781 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 590998005782 NlpC/P60 family; Region: NLPC_P60; pfam00877 590998005783 Domain of unknown function (DUF305); Region: DUF305; pfam03713 590998005784 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 590998005785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998005786 active site 590998005787 phosphorylation site [posttranslational modification] 590998005788 intermolecular recognition site; other site 590998005789 dimerization interface [polypeptide binding]; other site 590998005790 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 590998005791 DNA binding site [nucleotide binding] 590998005792 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 590998005793 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 590998005794 dimer interface [polypeptide binding]; other site 590998005795 phosphorylation site [posttranslational modification] 590998005796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998005797 ATP binding site [chemical binding]; other site 590998005798 Mg2+ binding site [ion binding]; other site 590998005799 G-X-G motif; other site 590998005800 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 590998005801 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 590998005802 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 590998005803 cofactor binding site; other site 590998005804 metal binding site [ion binding]; metal-binding site 590998005805 phenol 2-monooxygenase; Provisional; Region: PRK08294 590998005806 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 590998005807 dimer interface [polypeptide binding]; other site 590998005808 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 590998005809 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 590998005810 PYR/PP interface [polypeptide binding]; other site 590998005811 dimer interface [polypeptide binding]; other site 590998005812 TPP binding site [chemical binding]; other site 590998005813 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 590998005814 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 590998005815 TPP-binding site [chemical binding]; other site 590998005816 hypothetical protein; Provisional; Region: PRK12764 590998005817 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 590998005818 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 590998005819 Transcriptional regulators [Transcription]; Region: GntR; COG1802 590998005820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 590998005821 DNA-binding site [nucleotide binding]; DNA binding site 590998005822 FCD domain; Region: FCD; pfam07729 590998005823 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 590998005824 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 590998005825 NAD binding site [chemical binding]; other site 590998005826 catalytic residues [active] 590998005827 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 590998005828 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 590998005829 tetramer interface [polypeptide binding]; other site 590998005830 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 590998005831 tetramer interface [polypeptide binding]; other site 590998005832 active site 590998005833 metal binding site [ion binding]; metal-binding site 590998005834 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 590998005835 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 590998005836 META domain; Region: META; pfam03724 590998005837 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 590998005838 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998005839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998005840 active site 590998005841 phosphorylation site [posttranslational modification] 590998005842 intermolecular recognition site; other site 590998005843 dimerization interface [polypeptide binding]; other site 590998005844 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998005845 DNA binding residues [nucleotide binding] 590998005846 dimerization interface [polypeptide binding]; other site 590998005847 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 590998005848 Amidinotransferase; Region: Amidinotransf; cl12043 590998005849 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 590998005850 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 590998005851 active site 590998005852 catalytic tetrad [active] 590998005853 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 590998005854 catalytic core [active] 590998005855 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 590998005856 putative ATP binding site [chemical binding]; other site 590998005857 putative substrate binding site [chemical binding]; other site 590998005858 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 590998005859 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 590998005860 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 590998005861 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 590998005862 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 590998005863 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 590998005864 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 590998005865 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 590998005866 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 590998005867 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 590998005868 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 590998005869 Soluble P-type ATPase [General function prediction only]; Region: COG4087 590998005870 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 590998005871 AAA domain; Region: AAA_22; pfam13401 590998005872 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998005873 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998005874 DNA binding residues [nucleotide binding] 590998005875 Short C-terminal domain; Region: SHOCT; pfam09851 590998005876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998005877 putative substrate translocation pore; other site 590998005878 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 590998005879 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 590998005880 Short C-terminal domain; Region: SHOCT; pfam09851 590998005881 Ion channel; Region: Ion_trans_2; pfam07885 590998005882 AP endonuclease family 2; Region: AP2Ec; smart00518 590998005883 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 590998005884 AP (apurinic/apyrimidinic) site pocket; other site 590998005885 DNA interaction; other site 590998005886 Metal-binding active site; metal-binding site 590998005887 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 590998005888 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 590998005889 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 590998005890 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 590998005891 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 590998005892 active site 590998005893 catalytic site [active] 590998005894 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 590998005895 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 590998005896 active site 590998005897 catalytic site [active] 590998005898 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 590998005899 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 590998005900 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 590998005901 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 590998005902 catalytic site [active] 590998005903 active site 590998005904 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 590998005905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 590998005906 Walker A motif; other site 590998005907 ATP binding site [chemical binding]; other site 590998005908 Walker B motif; other site 590998005909 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 590998005910 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 590998005911 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 590998005912 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 590998005913 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 590998005914 Active Sites [active] 590998005915 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 590998005916 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 590998005917 Active Sites [active] 590998005918 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 590998005919 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 590998005920 CysD dimerization site [polypeptide binding]; other site 590998005921 G1 box; other site 590998005922 putative GEF interaction site [polypeptide binding]; other site 590998005923 GTP/Mg2+ binding site [chemical binding]; other site 590998005924 Switch I region; other site 590998005925 G2 box; other site 590998005926 G3 box; other site 590998005927 Switch II region; other site 590998005928 G4 box; other site 590998005929 G5 box; other site 590998005930 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 590998005931 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 590998005932 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 590998005933 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 590998005934 homodimer interface [polypeptide binding]; other site 590998005935 active site 590998005936 SAM binding site [chemical binding]; other site 590998005937 RibD C-terminal domain; Region: RibD_C; cl17279 590998005938 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 590998005939 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 590998005940 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 590998005941 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 590998005942 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 590998005943 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998005944 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998005945 DNA binding residues [nucleotide binding] 590998005946 dimerization interface [polypeptide binding]; other site 590998005947 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 590998005948 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 590998005949 catalytic site [active] 590998005950 putative active site [active] 590998005951 putative substrate binding site [chemical binding]; other site 590998005952 HRDC domain; Region: HRDC; pfam00570 590998005953 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 590998005954 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 590998005955 dimer interface [polypeptide binding]; other site 590998005956 active site 590998005957 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 590998005958 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 590998005959 substrate binding site [chemical binding]; other site 590998005960 oxyanion hole (OAH) forming residues; other site 590998005961 trimer interface [polypeptide binding]; other site 590998005962 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 590998005963 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 590998005964 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 590998005965 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 590998005966 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 590998005967 FeS/SAM binding site; other site 590998005968 Pyruvate formate lyase 1; Region: PFL1; cd01678 590998005969 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 590998005970 coenzyme A binding site [chemical binding]; other site 590998005971 active site 590998005972 catalytic residues [active] 590998005973 glycine loop; other site 590998005974 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 590998005975 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 590998005976 TPP-binding site; other site 590998005977 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 590998005978 PYR/PP interface [polypeptide binding]; other site 590998005979 dimer interface [polypeptide binding]; other site 590998005980 TPP binding site [chemical binding]; other site 590998005981 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 590998005982 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 590998005983 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 590998005984 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 590998005985 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 590998005986 active site 590998005987 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 590998005988 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 590998005989 catalytic triad [active] 590998005990 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 590998005991 putative active site [active] 590998005992 putative CoA binding site [chemical binding]; other site 590998005993 nudix motif; other site 590998005994 metal binding site [ion binding]; metal-binding site 590998005995 Phosphotransferase enzyme family; Region: APH; pfam01636 590998005996 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 590998005997 active site 590998005998 substrate binding site [chemical binding]; other site 590998005999 ATP binding site [chemical binding]; other site 590998006000 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 590998006001 active site 590998006002 Mn binding site [ion binding]; other site 590998006003 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 590998006004 aconitate hydratase; Validated; Region: PRK09277 590998006005 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 590998006006 substrate binding site [chemical binding]; other site 590998006007 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 590998006008 ligand binding site [chemical binding]; other site 590998006009 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 590998006010 substrate binding site [chemical binding]; other site 590998006011 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 590998006012 TRAM domain; Region: TRAM; pfam01938 590998006013 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 590998006014 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 590998006015 TrkA-N domain; Region: TrkA_N; pfam02254 590998006016 TrkA-C domain; Region: TrkA_C; pfam02080 590998006017 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 590998006018 TrkA-N domain; Region: TrkA_N; pfam02254 590998006019 TrkA-C domain; Region: TrkA_C; pfam02080 590998006020 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 590998006021 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 590998006022 ssDNA binding site; other site 590998006023 generic binding surface II; other site 590998006024 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 590998006025 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 590998006026 trimer interface [polypeptide binding]; other site 590998006027 active site 590998006028 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 590998006029 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 590998006030 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 590998006031 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 590998006032 active site 590998006033 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 590998006034 thymidine kinase; Provisional; Region: PRK04296 590998006035 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 590998006036 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 590998006037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998006038 Coenzyme A binding pocket [chemical binding]; other site 590998006039 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 590998006040 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 590998006041 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 590998006042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 590998006043 CAP-like domain; other site 590998006044 active site 590998006045 primary dimer interface [polypeptide binding]; other site 590998006046 YhhN-like protein; Region: YhhN; pfam07947 590998006047 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 590998006048 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 590998006049 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 590998006050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998006051 Mg2+ binding site [ion binding]; other site 590998006052 G-X-G motif; other site 590998006053 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 590998006054 anchoring element; other site 590998006055 dimer interface [polypeptide binding]; other site 590998006056 ATP binding site [chemical binding]; other site 590998006057 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 590998006058 active site 590998006059 metal binding site [ion binding]; metal-binding site 590998006060 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 590998006061 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 590998006062 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 590998006063 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998006064 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 590998006065 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 590998006066 DNA binding residues [nucleotide binding] 590998006067 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 590998006068 Ligand Binding Site [chemical binding]; other site 590998006069 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 590998006070 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 590998006071 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 590998006072 substrate binding pocket [chemical binding]; other site 590998006073 chain length determination region; other site 590998006074 substrate-Mg2+ binding site; other site 590998006075 catalytic residues [active] 590998006076 aspartate-rich region 1; other site 590998006077 active site lid residues [active] 590998006078 aspartate-rich region 2; other site 590998006079 Helix-turn-helix domain; Region: HTH_17; cl17695 590998006080 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 590998006081 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 590998006082 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 590998006083 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 590998006084 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 590998006085 N-acetyl-D-glucosamine binding site [chemical binding]; other site 590998006086 catalytic residue [active] 590998006087 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 590998006088 Catalytic domain of Protein Kinases; Region: PKc; cd00180 590998006089 active site 590998006090 ATP binding site [chemical binding]; other site 590998006091 substrate binding site [chemical binding]; other site 590998006092 activation loop (A-loop); other site 590998006093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 590998006094 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 590998006095 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 590998006096 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 590998006097 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 590998006098 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 590998006099 active site 590998006100 ADP/pyrophosphate binding site [chemical binding]; other site 590998006101 allosteric effector site; other site 590998006102 dimerization interface [polypeptide binding]; other site 590998006103 fructose-1,6-bisphosphate binding site; other site 590998006104 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 590998006105 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 590998006106 putative acyl-acceptor binding pocket; other site 590998006107 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 590998006108 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 590998006109 nucleotide binding site [chemical binding]; other site 590998006110 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 590998006111 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 590998006112 acyl-activating enzyme (AAE) consensus motif; other site 590998006113 putative AMP binding site [chemical binding]; other site 590998006114 putative active site [active] 590998006115 putative CoA binding site [chemical binding]; other site 590998006116 YacP-like NYN domain; Region: NYN_YacP; cl01491 590998006117 hypothetical protein; Validated; Region: PRK07883 590998006118 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 590998006119 active site 590998006120 catalytic site [active] 590998006121 substrate binding site [chemical binding]; other site 590998006122 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 590998006123 GIY-YIG motif/motif A; other site 590998006124 active site 590998006125 catalytic site [active] 590998006126 putative DNA binding site [nucleotide binding]; other site 590998006127 metal binding site [ion binding]; metal-binding site 590998006128 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 590998006129 AsnC family; Region: AsnC_trans_reg; pfam01037 590998006130 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 590998006131 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 590998006132 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 590998006133 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 590998006134 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 590998006135 Subunit I/III interface [polypeptide binding]; other site 590998006136 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 590998006137 Cytochrome c; Region: Cytochrom_C; pfam00034 590998006138 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 590998006139 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 590998006140 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 590998006141 iron-sulfur cluster [ion binding]; other site 590998006142 [2Fe-2S] cluster binding site [ion binding]; other site 590998006143 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 590998006144 heme bH binding site [chemical binding]; other site 590998006145 intrachain domain interface; other site 590998006146 heme bL binding site [chemical binding]; other site 590998006147 interchain domain interface [polypeptide binding]; other site 590998006148 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 590998006149 Qo binding site; other site 590998006150 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 590998006151 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 590998006152 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 590998006153 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 590998006154 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 590998006155 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 590998006156 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 590998006157 D-pathway; other site 590998006158 Putative ubiquinol binding site [chemical binding]; other site 590998006159 Low-spin heme (heme b) binding site [chemical binding]; other site 590998006160 Putative water exit pathway; other site 590998006161 Binuclear center (heme o3/CuB) [ion binding]; other site 590998006162 K-pathway; other site 590998006163 Putative proton exit pathway; other site 590998006164 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 590998006165 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 590998006166 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 590998006167 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 590998006168 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 590998006169 CPxP motif; other site 590998006170 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 590998006171 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 590998006172 quinolinate synthetase; Provisional; Region: PRK09375 590998006173 DJ-1 family protein; Region: not_thiJ; TIGR01383 590998006174 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 590998006175 conserved cys residue [active] 590998006176 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 590998006177 active site 590998006178 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 590998006179 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 590998006180 active site 590998006181 metal binding site [ion binding]; metal-binding site 590998006182 dimer interface [polypeptide binding]; other site 590998006183 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 590998006184 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 590998006185 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 590998006186 active site 590998006187 catalytic tetrad [active] 590998006188 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 590998006189 Predicted membrane protein [Function unknown]; Region: COG2364 590998006190 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 590998006191 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 590998006192 DNA-binding site [nucleotide binding]; DNA binding site 590998006193 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 590998006194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998006195 homodimer interface [polypeptide binding]; other site 590998006196 catalytic residue [active] 590998006197 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 590998006198 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 590998006199 quinone interaction residues [chemical binding]; other site 590998006200 active site 590998006201 catalytic residues [active] 590998006202 FMN binding site [chemical binding]; other site 590998006203 substrate binding site [chemical binding]; other site 590998006204 multifunctional aminopeptidase A; Provisional; Region: PRK00913 590998006205 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 590998006206 interface (dimer of trimers) [polypeptide binding]; other site 590998006207 Substrate-binding/catalytic site; other site 590998006208 Zn-binding sites [ion binding]; other site 590998006209 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 590998006210 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 590998006211 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 590998006212 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 590998006213 E3 interaction surface; other site 590998006214 lipoyl attachment site [posttranslational modification]; other site 590998006215 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 590998006216 E3 interaction surface; other site 590998006217 lipoyl attachment site [posttranslational modification]; other site 590998006218 e3 binding domain; Region: E3_binding; pfam02817 590998006219 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 590998006220 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 590998006221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998006222 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 590998006223 NAD(P) binding site [chemical binding]; other site 590998006224 active site 590998006225 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 590998006226 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 590998006227 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 590998006228 MMPL family; Region: MMPL; pfam03176 590998006229 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 590998006230 non-specific DNA interactions [nucleotide binding]; other site 590998006231 DNA binding site [nucleotide binding] 590998006232 sequence specific DNA binding site [nucleotide binding]; other site 590998006233 putative cAMP binding site [chemical binding]; other site 590998006234 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 590998006235 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 590998006236 lipoyl synthase; Provisional; Region: PRK05481 590998006237 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 590998006238 FeS/SAM binding site; other site 590998006239 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 590998006240 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 590998006241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998006242 Methyltransferase domain; Region: Methyltransf_31; pfam13847 590998006243 S-adenosylmethionine binding site [chemical binding]; other site 590998006244 glutamine synthetase, type I; Region: GlnA; TIGR00653 590998006245 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 590998006246 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 590998006247 Septum formation; Region: Septum_form; pfam13845 590998006248 TM2 domain; Region: TM2; pfam05154 590998006249 Transcription elongation factor Elf1 like; Region: Elf1; cl02038 590998006250 PAS fold; Region: PAS_4; pfam08448 590998006251 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 590998006252 putative active site [active] 590998006253 heme pocket [chemical binding]; other site 590998006254 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 590998006255 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 590998006256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 590998006257 PAS fold; Region: PAS_3; pfam08447 590998006258 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 590998006259 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 590998006260 anti sigma factor interaction site; other site 590998006261 regulatory phosphorylation site [posttranslational modification]; other site 590998006262 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 590998006263 trehalose synthase; Region: treS_nterm; TIGR02456 590998006264 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 590998006265 active site 590998006266 catalytic site [active] 590998006267 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 590998006268 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 590998006269 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 590998006270 Domain of unknown function DUF20; Region: UPF0118; pfam01594 590998006271 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 590998006272 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 590998006273 metal binding triad; other site 590998006274 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 590998006275 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 590998006276 metal binding triad; other site 590998006277 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 590998006278 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 590998006279 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 590998006280 NAD synthetase; Provisional; Region: PRK13981 590998006281 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 590998006282 multimer interface [polypeptide binding]; other site 590998006283 active site 590998006284 catalytic triad [active] 590998006285 protein interface 1 [polypeptide binding]; other site 590998006286 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 590998006287 homodimer interface [polypeptide binding]; other site 590998006288 NAD binding pocket [chemical binding]; other site 590998006289 ATP binding pocket [chemical binding]; other site 590998006290 Mg binding site [ion binding]; other site 590998006291 active-site loop [active] 590998006292 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 590998006293 oligomerization interface [polypeptide binding]; other site 590998006294 active site 590998006295 metal binding site [ion binding]; metal-binding site 590998006296 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 590998006297 putative catalytic site [active] 590998006298 putative phosphate binding site [ion binding]; other site 590998006299 putative metal binding site [ion binding]; other site 590998006300 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 590998006301 active site 590998006302 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 590998006303 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 590998006304 hypothetical protein; Validated; Region: PRK02101 590998006305 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 590998006306 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 590998006307 active site 590998006308 RNA/DNA hybrid binding site [nucleotide binding]; other site 590998006309 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 590998006310 catalytic core [active] 590998006311 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 590998006312 Putative zinc ribbon domain; Region: DUF164; pfam02591 590998006313 Uncharacterized conserved protein [Function unknown]; Region: COG0327 590998006314 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 590998006315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 590998006316 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 590998006317 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 590998006318 MOSC domain; Region: MOSC; pfam03473 590998006319 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 590998006320 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 590998006321 dimer interface [polypeptide binding]; other site 590998006322 catalytic triad [active] 590998006323 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 590998006324 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 590998006325 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 590998006326 dimer interface [polypeptide binding]; other site 590998006327 TPP-binding site [chemical binding]; other site 590998006328 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 590998006329 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 590998006330 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 590998006331 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 590998006332 dimer interface [polypeptide binding]; other site 590998006333 active site 590998006334 CoA binding pocket [chemical binding]; other site 590998006335 acyl carrier protein; Provisional; Region: acpP; PRK00982 590998006336 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 590998006337 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 590998006338 dimer interface [polypeptide binding]; other site 590998006339 active site 590998006340 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 590998006341 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 590998006342 active site 590998006343 catalytic residues [active] 590998006344 metal binding site [ion binding]; metal-binding site 590998006345 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 590998006346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998006347 Walker A/P-loop; other site 590998006348 ATP binding site [chemical binding]; other site 590998006349 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 590998006350 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 590998006351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998006352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998006353 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 590998006354 DNA binding residues [nucleotide binding] 590998006355 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 590998006356 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 590998006357 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998006358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998006359 dimer interface [polypeptide binding]; other site 590998006360 conserved gate region; other site 590998006361 putative PBP binding loops; other site 590998006362 ABC-ATPase subunit interface; other site 590998006363 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 590998006364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998006365 putative PBP binding loops; other site 590998006366 dimer interface [polypeptide binding]; other site 590998006367 ABC-ATPase subunit interface; other site 590998006368 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998006369 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 590998006370 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 590998006371 active site 590998006372 catalytic site [active] 590998006373 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 590998006374 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 590998006375 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 590998006376 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 590998006377 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 590998006378 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 590998006379 active site residue [active] 590998006380 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 590998006381 putative homodimer interface [polypeptide binding]; other site 590998006382 putative homotetramer interface [polypeptide binding]; other site 590998006383 putative allosteric switch controlling residues; other site 590998006384 putative metal binding site [ion binding]; other site 590998006385 putative homodimer-homodimer interface [polypeptide binding]; other site 590998006386 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 590998006387 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 590998006388 G1 box; other site 590998006389 GTP/Mg2+ binding site [chemical binding]; other site 590998006390 G2 box; other site 590998006391 Switch I region; other site 590998006392 G3 box; other site 590998006393 Switch II region; other site 590998006394 G4 box; other site 590998006395 G5 box; other site 590998006396 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 590998006397 Nucleoside recognition; Region: Gate; pfam07670 590998006398 FOG: CBS domain [General function prediction only]; Region: COG0517 590998006399 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 590998006400 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 590998006401 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 590998006402 metal binding site [ion binding]; metal-binding site 590998006403 active site 590998006404 I-site; other site 590998006405 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 590998006406 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 590998006407 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 590998006408 Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546 590998006409 dinuclear metal binding motif [ion binding]; other site 590998006410 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 590998006411 putative trimer interface [polypeptide binding]; other site 590998006412 putative CoA binding site [chemical binding]; other site 590998006413 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 590998006414 Catalytic domain of Protein Kinases; Region: PKc; cd00180 590998006415 active site 590998006416 ATP binding site [chemical binding]; other site 590998006417 substrate binding site [chemical binding]; other site 590998006418 activation loop (A-loop); other site 590998006419 Predicted membrane protein [Function unknown]; Region: COG2860 590998006420 UPF0126 domain; Region: UPF0126; pfam03458 590998006421 UPF0126 domain; Region: UPF0126; pfam03458 590998006422 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 590998006423 active site 590998006424 metal binding site [ion binding]; metal-binding site 590998006425 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 590998006426 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 590998006427 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 590998006428 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 590998006429 DNA primase, catalytic core; Region: dnaG; TIGR01391 590998006430 CHC2 zinc finger; Region: zf-CHC2; cl17510 590998006431 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 590998006432 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 590998006433 active site 590998006434 metal binding site [ion binding]; metal-binding site 590998006435 interdomain interaction site; other site 590998006436 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 590998006437 Helix-turn-helix domain; Region: HTH_18; pfam12833 590998006438 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 590998006439 putative dimer interface [polypeptide binding]; other site 590998006440 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 590998006441 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 590998006442 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 590998006443 Zn2+ binding site [ion binding]; other site 590998006444 Mg2+ binding site [ion binding]; other site 590998006445 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 590998006446 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 590998006447 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 590998006448 homodimer interface [polypeptide binding]; other site 590998006449 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 590998006450 active site 590998006451 homodimer interface [polypeptide binding]; other site 590998006452 catalytic site [active] 590998006453 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998006454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998006455 conserved gate region; other site 590998006456 dimer interface [polypeptide binding]; other site 590998006457 putative PBP binding loops; other site 590998006458 ABC-ATPase subunit interface; other site 590998006459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998006460 dimer interface [polypeptide binding]; other site 590998006461 conserved gate region; other site 590998006462 putative PBP binding loops; other site 590998006463 ABC-ATPase subunit interface; other site 590998006464 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 590998006465 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 590998006466 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998006467 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998006468 DNA binding site [nucleotide binding] 590998006469 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 590998006470 putative dimerization interface [polypeptide binding]; other site 590998006471 putative ligand binding site [chemical binding]; other site 590998006472 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 590998006473 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 590998006474 active site 590998006475 catalytic site [active] 590998006476 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 590998006477 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 590998006478 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 590998006479 active site 590998006480 Ca binding site [ion binding]; other site 590998006481 catalytic site [active] 590998006482 Aamy_C domain; Region: Aamy_C; smart00632 590998006483 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 590998006484 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 590998006485 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 590998006486 FMN binding site [chemical binding]; other site 590998006487 active site 590998006488 catalytic residues [active] 590998006489 substrate binding site [chemical binding]; other site 590998006490 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 590998006491 glycyl-tRNA synthetase; Provisional; Region: PRK04173 590998006492 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 590998006493 motif 1; other site 590998006494 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 590998006495 active site 590998006496 motif 2; other site 590998006497 motif 3; other site 590998006498 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 590998006499 anticodon binding site; other site 590998006500 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 590998006501 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 590998006502 intersubunit interface [polypeptide binding]; other site 590998006503 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 590998006504 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 590998006505 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 590998006506 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 590998006507 ABC-ATPase subunit interface; other site 590998006508 dimer interface [polypeptide binding]; other site 590998006509 putative PBP binding regions; other site 590998006510 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 590998006511 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 590998006512 active site 590998006513 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 590998006514 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 590998006515 catalytic residue [active] 590998006516 putative FPP diphosphate binding site; other site 590998006517 putative FPP binding hydrophobic cleft; other site 590998006518 dimer interface [polypeptide binding]; other site 590998006519 putative IPP diphosphate binding site; other site 590998006520 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 590998006521 Recombination protein O N terminal; Region: RecO_N; pfam11967 590998006522 Recombination protein O C terminal; Region: RecO_C; pfam02565 590998006523 2-isopropylmalate synthase; Validated; Region: PRK03739 590998006524 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 590998006525 active site 590998006526 catalytic residues [active] 590998006527 metal binding site [ion binding]; metal-binding site 590998006528 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 590998006529 PQQ-like domain; Region: PQQ_2; pfam13360 590998006530 PQQ-like domain; Region: PQQ_2; pfam13360 590998006531 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 590998006532 active site 590998006533 PQQ-like domain; Region: PQQ_2; pfam13360 590998006534 RDD family; Region: RDD; pfam06271 590998006535 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 590998006536 phosphopeptide binding site; other site 590998006537 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 590998006538 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 590998006539 Protein of unknown function DUF58; Region: DUF58; pfam01882 590998006540 MoxR-like ATPases [General function prediction only]; Region: COG0714 590998006541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 590998006542 Walker A motif; other site 590998006543 ATP binding site [chemical binding]; other site 590998006544 Walker B motif; other site 590998006545 arginine finger; other site 590998006546 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 590998006547 Interdomain contacts; other site 590998006548 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 590998006549 Interdomain contacts; other site 590998006550 Cytokine receptor motif; other site 590998006551 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 590998006552 Interdomain contacts; other site 590998006553 Cytokine receptor motif; other site 590998006554 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 590998006555 Interdomain contacts; other site 590998006556 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 590998006557 Interdomain contacts; other site 590998006558 Cytokine receptor motif; other site 590998006559 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 590998006560 Catalytic domain of Protein Kinases; Region: PKc; cd00180 590998006561 active site 590998006562 ATP binding site [chemical binding]; other site 590998006563 substrate binding site [chemical binding]; other site 590998006564 activation loop (A-loop); other site 590998006565 FHA domain; Region: FHA; pfam00498 590998006566 phosphopeptide binding site; other site 590998006567 Protein phosphatase 2C; Region: PP2C; pfam00481 590998006568 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 590998006569 active site 590998006570 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 590998006571 GTPase Era; Reviewed; Region: era; PRK00089 590998006572 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 590998006573 G1 box; other site 590998006574 GTP/Mg2+ binding site [chemical binding]; other site 590998006575 Switch I region; other site 590998006576 G2 box; other site 590998006577 Switch II region; other site 590998006578 G3 box; other site 590998006579 G4 box; other site 590998006580 G5 box; other site 590998006581 KH domain; Region: KH_2; pfam07650 590998006582 Domain of unknown function DUF21; Region: DUF21; pfam01595 590998006583 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 590998006584 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 590998006585 Transporter associated domain; Region: CorC_HlyC; smart01091 590998006586 metal-binding heat shock protein; Provisional; Region: PRK00016 590998006587 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 590998006588 PhoH-like protein; Region: PhoH; pfam02562 590998006589 pyruvate phosphate dikinase; Provisional; Region: PRK09279 590998006590 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 590998006591 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 590998006592 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 590998006593 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 590998006594 RNA methyltransferase, RsmE family; Region: TIGR00046 590998006595 chaperone protein DnaJ; Provisional; Region: PRK14278 590998006596 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 590998006597 HSP70 interaction site [polypeptide binding]; other site 590998006598 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 590998006599 Zn binding sites [ion binding]; other site 590998006600 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 590998006601 dimer interface [polypeptide binding]; other site 590998006602 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 590998006603 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 590998006604 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 590998006605 Predicted membrane protein [Function unknown]; Region: COG4818 590998006606 Tic20-like protein; Region: Tic20; pfam09685 590998006607 Tic20-like protein; Region: Tic20; pfam09685 590998006608 coproporphyrinogen III oxidase; Validated; Region: PRK05628 590998006609 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 590998006610 FeS/SAM binding site; other site 590998006611 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 590998006612 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 590998006613 tetramer interface [polypeptide binding]; other site 590998006614 active site 590998006615 Mg2+/Mn2+ binding site [ion binding]; other site 590998006616 GTP-binding protein LepA; Provisional; Region: PRK05433 590998006617 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 590998006618 G1 box; other site 590998006619 putative GEF interaction site [polypeptide binding]; other site 590998006620 GTP/Mg2+ binding site [chemical binding]; other site 590998006621 Switch I region; other site 590998006622 G2 box; other site 590998006623 G3 box; other site 590998006624 Switch II region; other site 590998006625 G4 box; other site 590998006626 G5 box; other site 590998006627 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 590998006628 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 590998006629 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 590998006630 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 590998006631 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 590998006632 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 590998006633 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 590998006634 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 590998006635 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 590998006636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 590998006637 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 590998006638 PemK-like protein; Region: PemK; pfam02452 590998006639 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 590998006640 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 590998006641 non-specific DNA binding site [nucleotide binding]; other site 590998006642 salt bridge; other site 590998006643 sequence-specific DNA binding site [nucleotide binding]; other site 590998006644 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 590998006645 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 590998006646 hypothetical protein; Reviewed; Region: PRK07914 590998006647 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 590998006648 Competence protein; Region: Competence; cl00471 590998006649 SLBB domain; Region: SLBB; pfam10531 590998006650 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 590998006651 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 590998006652 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 590998006653 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 590998006654 active site 590998006655 HIGH motif; other site 590998006656 nucleotide binding site [chemical binding]; other site 590998006657 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 590998006658 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 590998006659 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 590998006660 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 590998006661 active site 590998006662 KMSKS motif; other site 590998006663 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 590998006664 tRNA binding surface [nucleotide binding]; other site 590998006665 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 590998006666 Domain of unknown function DUF87; Region: DUF87; pfam01935 590998006667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998006668 putative substrate translocation pore; other site 590998006669 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 590998006670 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 590998006671 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 590998006672 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 590998006673 dimerization interface [polypeptide binding]; other site 590998006674 mannose binding site [chemical binding]; other site 590998006675 D-mannose binding lectin; Region: B_lectin; pfam01453 590998006676 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 590998006677 mannose binding site [chemical binding]; other site 590998006678 dimerization interface [polypeptide binding]; other site 590998006679 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 590998006680 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 590998006681 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 590998006682 active site 590998006683 metal binding site [ion binding]; metal-binding site 590998006684 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 590998006685 hydrophobic ligand binding site; other site 590998006686 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 590998006687 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 590998006688 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 590998006689 Walker A/P-loop; other site 590998006690 ATP binding site [chemical binding]; other site 590998006691 Q-loop/lid; other site 590998006692 ABC transporter signature motif; other site 590998006693 Walker B; other site 590998006694 D-loop; other site 590998006695 H-loop/switch region; other site 590998006696 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 590998006697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998006698 Q-loop/lid; other site 590998006699 ABC transporter signature motif; other site 590998006700 Walker B; other site 590998006701 D-loop; other site 590998006702 H-loop/switch region; other site 590998006703 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 590998006704 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 590998006705 putative active site; other site 590998006706 putative metal binding residues [ion binding]; other site 590998006707 signature motif; other site 590998006708 putative triphosphate binding site [ion binding]; other site 590998006709 CHAD domain; Region: CHAD; pfam05235 590998006710 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 590998006711 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 590998006712 putative metal binding site [ion binding]; other site 590998006713 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 590998006714 active site 590998006715 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 590998006716 putative active site; other site 590998006717 putative triphosphate binding site [ion binding]; other site 590998006718 putative metal binding residues [ion binding]; other site 590998006719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 590998006720 DEAD-like helicases superfamily; Region: DEXDc; smart00487 590998006721 ATP binding site [chemical binding]; other site 590998006722 putative Mg++ binding site [ion binding]; other site 590998006723 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 590998006724 nucleotide binding region [chemical binding]; other site 590998006725 ATP-binding site [chemical binding]; other site 590998006726 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 590998006727 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 590998006728 Moco binding site; other site 590998006729 metal coordination site [ion binding]; other site 590998006730 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 590998006731 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 590998006732 FAD binding pocket [chemical binding]; other site 590998006733 FAD binding motif [chemical binding]; other site 590998006734 phosphate binding motif [ion binding]; other site 590998006735 beta-alpha-beta structure motif; other site 590998006736 NAD binding pocket [chemical binding]; other site 590998006737 RNA polymerase factor sigma-70; Validated; Region: PRK08241 590998006738 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998006739 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 590998006740 DNA binding residues [nucleotide binding] 590998006741 SnoaL-like domain; Region: SnoaL_2; pfam12680 590998006742 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 590998006743 nudix motif; other site 590998006744 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 590998006745 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 590998006746 RDD family; Region: RDD; pfam06271 590998006747 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 590998006748 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 590998006749 Chromate transporter; Region: Chromate_transp; pfam02417 590998006750 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 590998006751 PAS fold; Region: PAS_3; pfam08447 590998006752 putative active site [active] 590998006753 heme pocket [chemical binding]; other site 590998006754 PAS fold; Region: PAS_4; pfam08448 590998006755 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 590998006756 putative active site [active] 590998006757 heme pocket [chemical binding]; other site 590998006758 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 590998006759 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 590998006760 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 590998006761 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 590998006762 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 590998006763 ATP binding site [chemical binding]; other site 590998006764 Mg2+ binding site [ion binding]; other site 590998006765 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 590998006766 Domain of unknown function (DUF389); Region: DUF389; cl00781 590998006767 Domain of unknown function (DUF389); Region: DUF389; pfam04087 590998006768 DNA polymerase IV; Validated; Region: PRK03352 590998006769 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 590998006770 active site 590998006771 DNA binding site [nucleotide binding] 590998006772 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 590998006773 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 590998006774 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 590998006775 putative sugar binding sites [chemical binding]; other site 590998006776 Q-X-W motif; other site 590998006777 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 590998006778 short chain dehydrogenase; Provisional; Region: PRK06197 590998006779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998006780 NAD(P) binding site [chemical binding]; other site 590998006781 active site 590998006782 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 590998006783 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 590998006784 active site 590998006785 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 590998006786 catalytic core [active] 590998006787 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 590998006788 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 590998006789 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 590998006790 active site 590998006791 (T/H)XGH motif; other site 590998006792 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 590998006793 putative catalytic cysteine [active] 590998006794 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 590998006795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998006796 Coenzyme A binding pocket [chemical binding]; other site 590998006797 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 590998006798 active site residue [active] 590998006799 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 590998006800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998006801 conserved gate region; other site 590998006802 ABC-ATPase subunit interface; other site 590998006803 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 590998006804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998006805 putative PBP binding loops; other site 590998006806 dimer interface [polypeptide binding]; other site 590998006807 ABC-ATPase subunit interface; other site 590998006808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998006809 Walker A/P-loop; other site 590998006810 ATP binding site [chemical binding]; other site 590998006811 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 590998006812 Winged helix-turn helix; Region: HTH_29; pfam13551 590998006813 Integrase core domain; Region: rve; pfam00665 590998006814 Integrase core domain; Region: rve_3; pfam13683 590998006815 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 590998006816 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 590998006817 ABC transporter signature motif; other site 590998006818 Walker B; other site 590998006819 D-loop; other site 590998006820 H-loop/switch region; other site 590998006821 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 590998006822 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 590998006823 Walker A/P-loop; other site 590998006824 ATP binding site [chemical binding]; other site 590998006825 Q-loop/lid; other site 590998006826 ABC transporter signature motif; other site 590998006827 Walker B; other site 590998006828 D-loop; other site 590998006829 H-loop/switch region; other site 590998006830 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 590998006831 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 590998006832 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 590998006833 gamma-glutamyl kinase; Provisional; Region: PRK05429 590998006834 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 590998006835 nucleotide binding site [chemical binding]; other site 590998006836 homotetrameric interface [polypeptide binding]; other site 590998006837 putative phosphate binding site [ion binding]; other site 590998006838 putative allosteric binding site; other site 590998006839 PUA domain; Region: PUA; pfam01472 590998006840 GTPase CgtA; Reviewed; Region: obgE; PRK12296 590998006841 GTP1/OBG; Region: GTP1_OBG; pfam01018 590998006842 Obg GTPase; Region: Obg; cd01898 590998006843 G1 box; other site 590998006844 GTP/Mg2+ binding site [chemical binding]; other site 590998006845 Switch I region; other site 590998006846 G2 box; other site 590998006847 G3 box; other site 590998006848 Switch II region; other site 590998006849 G4 box; other site 590998006850 G5 box; other site 590998006851 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 590998006852 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 590998006853 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 590998006854 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 590998006855 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 590998006856 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 590998006857 homodimer interface [polypeptide binding]; other site 590998006858 oligonucleotide binding site [chemical binding]; other site 590998006859 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 590998006860 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 590998006861 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 590998006862 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 590998006863 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 590998006864 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 590998006865 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 590998006866 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 590998006867 Walker A/P-loop; other site 590998006868 ATP binding site [chemical binding]; other site 590998006869 Q-loop/lid; other site 590998006870 ABC transporter signature motif; other site 590998006871 Walker B; other site 590998006872 D-loop; other site 590998006873 H-loop/switch region; other site 590998006874 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 590998006875 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998006876 Walker A/P-loop; other site 590998006877 ATP binding site [chemical binding]; other site 590998006878 Q-loop/lid; other site 590998006879 ABC transporter signature motif; other site 590998006880 Walker B; other site 590998006881 D-loop; other site 590998006882 H-loop/switch region; other site 590998006883 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 590998006884 GAF domain; Region: GAF; pfam01590 590998006885 GAF domain; Region: GAF_3; pfam13492 590998006886 Histidine kinase; Region: HisKA_3; pfam07730 590998006887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998006888 ATP binding site [chemical binding]; other site 590998006889 Mg2+ binding site [ion binding]; other site 590998006890 G-X-G motif; other site 590998006891 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998006892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998006893 active site 590998006894 phosphorylation site [posttranslational modification] 590998006895 intermolecular recognition site; other site 590998006896 dimerization interface [polypeptide binding]; other site 590998006897 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998006898 DNA binding residues [nucleotide binding] 590998006899 dimerization interface [polypeptide binding]; other site 590998006900 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 590998006901 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 590998006902 NAD binding site [chemical binding]; other site 590998006903 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 590998006904 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 590998006905 DNA binding site [nucleotide binding] 590998006906 catalytic residue [active] 590998006907 H2TH interface [polypeptide binding]; other site 590998006908 putative catalytic residues [active] 590998006909 turnover-facilitating residue; other site 590998006910 intercalation triad [nucleotide binding]; other site 590998006911 8OG recognition residue [nucleotide binding]; other site 590998006912 putative reading head residues; other site 590998006913 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 590998006914 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 590998006915 ribonuclease III; Reviewed; Region: rnc; PRK00102 590998006916 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 590998006917 dimerization interface [polypeptide binding]; other site 590998006918 active site 590998006919 metal binding site [ion binding]; metal-binding site 590998006920 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 590998006921 dsRNA binding site [nucleotide binding]; other site 590998006922 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 590998006923 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 590998006924 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 590998006925 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 590998006926 active site 590998006927 nucleotide binding site [chemical binding]; other site 590998006928 HIGH motif; other site 590998006929 KMSKS motif; other site 590998006930 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 590998006931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998006932 S-adenosylmethionine binding site [chemical binding]; other site 590998006933 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998006934 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 590998006935 Walker A/P-loop; other site 590998006936 ATP binding site [chemical binding]; other site 590998006937 Q-loop/lid; other site 590998006938 ABC transporter signature motif; other site 590998006939 Walker B; other site 590998006940 D-loop; other site 590998006941 H-loop/switch region; other site 590998006942 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 590998006943 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 590998006944 ssDNA binding site; other site 590998006945 generic binding surface II; other site 590998006946 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 590998006947 ATP binding site [chemical binding]; other site 590998006948 putative Mg++ binding site [ion binding]; other site 590998006949 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 590998006950 nucleotide binding region [chemical binding]; other site 590998006951 ATP-binding site [chemical binding]; other site 590998006952 DAK2 domain; Region: Dak2; cl03685 590998006953 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 590998006954 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998006955 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 590998006956 Coenzyme A binding pocket [chemical binding]; other site 590998006957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 590998006958 thiamine monophosphate kinase; Provisional; Region: PRK05731 590998006959 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 590998006960 ATP binding site [chemical binding]; other site 590998006961 dimerization interface [polypeptide binding]; other site 590998006962 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 590998006963 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 590998006964 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 590998006965 ATP-grasp domain; Region: ATP-grasp_4; cl17255 590998006966 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 590998006967 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 590998006968 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 590998006969 catalytic residue [active] 590998006970 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 590998006971 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 590998006972 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 590998006973 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 590998006974 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 590998006975 putative acyl-acceptor binding pocket; other site 590998006976 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 590998006977 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 590998006978 hinge; other site 590998006979 active site 590998006980 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 590998006981 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 590998006982 substrate binding site [chemical binding]; other site 590998006983 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 590998006984 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 590998006985 substrate binding site [chemical binding]; other site 590998006986 ligand binding site [chemical binding]; other site 590998006987 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 590998006988 Transcriptional regulator [Transcription]; Region: IclR; COG1414 590998006989 Bacterial transcriptional regulator; Region: IclR; pfam01614 590998006990 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 590998006991 Helix-turn-helix domain; Region: HTH_17; pfam12728 590998006992 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 590998006993 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 590998006994 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 590998006995 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 590998006996 EamA-like transporter family; Region: EamA; pfam00892 590998006997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 590998006998 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 590998006999 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 590998007000 30S subunit binding site; other site 590998007001 lipoprotein LpqB; Provisional; Region: PRK13614 590998007002 Sporulation and spore germination; Region: Germane; pfam10646 590998007003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 590998007004 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 590998007005 dimerization interface [polypeptide binding]; other site 590998007006 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 590998007007 dimer interface [polypeptide binding]; other site 590998007008 phosphorylation site [posttranslational modification] 590998007009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998007010 ATP binding site [chemical binding]; other site 590998007011 G-X-G motif; other site 590998007012 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 590998007013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998007014 active site 590998007015 phosphorylation site [posttranslational modification] 590998007016 intermolecular recognition site; other site 590998007017 dimerization interface [polypeptide binding]; other site 590998007018 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 590998007019 DNA binding site [nucleotide binding] 590998007020 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 590998007021 MoxR-like ATPases [General function prediction only]; Region: COG0714 590998007022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 590998007023 Walker A motif; other site 590998007024 ATP binding site [chemical binding]; other site 590998007025 Walker B motif; other site 590998007026 arginine finger; other site 590998007027 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 590998007028 Protein of unknown function DUF58; Region: DUF58; pfam01882 590998007029 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 590998007030 Integral membrane protein DUF95; Region: DUF95; pfam01944 590998007031 Predicted membrane protein/domain [Function unknown]; Region: COG1714 590998007032 Adenosylhomocysteinase; Provisional; Region: PTZ00075 590998007033 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 590998007034 homotetramer interface [polypeptide binding]; other site 590998007035 ligand binding site [chemical binding]; other site 590998007036 catalytic site [active] 590998007037 NAD binding site [chemical binding]; other site 590998007038 Trm112p-like protein; Region: Trm112p; cl01066 590998007039 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 590998007040 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 590998007041 active site 590998007042 substrate binding site [chemical binding]; other site 590998007043 metal binding site [ion binding]; metal-binding site 590998007044 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 590998007045 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 590998007046 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 590998007047 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 590998007048 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 590998007049 active site 590998007050 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 590998007051 Transcription factor WhiB; Region: Whib; pfam02467 590998007052 TIGR03089 family protein; Region: TIGR03089 590998007053 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 590998007054 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 590998007055 substrate binding site; other site 590998007056 tetramer interface; other site 590998007057 Predicted membrane protein [Function unknown]; Region: COG2246 590998007058 GtrA-like protein; Region: GtrA; pfam04138 590998007059 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 590998007060 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 590998007061 active site 590998007062 extended (e) SDRs; Region: SDR_e; cd08946 590998007063 substrate binding site [chemical binding]; other site 590998007064 active site 590998007065 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 590998007066 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 590998007067 Probable Catalytic site; other site 590998007068 metal-binding site 590998007069 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 590998007070 Ligand binding site; other site 590998007071 Putative Catalytic site; other site 590998007072 DXD motif; other site 590998007073 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 590998007074 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 590998007075 NADP binding site [chemical binding]; other site 590998007076 active site 590998007077 putative substrate binding site [chemical binding]; other site 590998007078 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 590998007079 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 590998007080 Ligand binding site; other site 590998007081 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 590998007082 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 590998007083 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 590998007084 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 590998007085 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 590998007086 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 590998007087 active site 590998007088 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 590998007089 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 590998007090 active site 590998007091 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 590998007092 amidase catalytic site [active] 590998007093 Zn binding residues [ion binding]; other site 590998007094 substrate binding site [chemical binding]; other site 590998007095 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 590998007096 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 590998007097 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 590998007098 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 590998007099 NAD binding site [chemical binding]; other site 590998007100 substrate binding site [chemical binding]; other site 590998007101 homodimer interface [polypeptide binding]; other site 590998007102 active site 590998007103 Methyltransferase domain; Region: Methyltransf_23; pfam13489 590998007104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998007105 S-adenosylmethionine binding site [chemical binding]; other site 590998007106 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 590998007107 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 590998007108 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 590998007109 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 590998007110 Walker A/P-loop; other site 590998007111 ATP binding site [chemical binding]; other site 590998007112 Q-loop/lid; other site 590998007113 ABC transporter signature motif; other site 590998007114 Walker B; other site 590998007115 D-loop; other site 590998007116 H-loop/switch region; other site 590998007117 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 590998007118 putative carbohydrate binding site [chemical binding]; other site 590998007119 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 590998007120 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 590998007121 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 590998007122 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 590998007123 AIR carboxylase; Region: AIRC; pfam00731 590998007124 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 590998007125 ATP-grasp domain; Region: ATP-grasp; pfam02222 590998007126 Predicted membrane protein [Function unknown]; Region: COG2246 590998007127 GtrA-like protein; Region: GtrA; pfam04138 590998007128 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 590998007129 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 590998007130 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 590998007131 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 590998007132 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 590998007133 dimer interface [polypeptide binding]; other site 590998007134 phosphorylation site [posttranslational modification] 590998007135 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 590998007136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998007137 active site 590998007138 phosphorylation site [posttranslational modification] 590998007139 intermolecular recognition site; other site 590998007140 dimerization interface [polypeptide binding]; other site 590998007141 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 590998007142 DNA binding site [nucleotide binding] 590998007143 Histidine kinase; Region: HisKA_3; pfam07730 590998007144 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 590998007145 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998007146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998007147 active site 590998007148 phosphorylation site [posttranslational modification] 590998007149 intermolecular recognition site; other site 590998007150 dimerization interface [polypeptide binding]; other site 590998007151 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998007152 DNA binding residues [nucleotide binding] 590998007153 dimerization interface [polypeptide binding]; other site 590998007154 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 590998007155 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 590998007156 Walker A/P-loop; other site 590998007157 ATP binding site [chemical binding]; other site 590998007158 Q-loop/lid; other site 590998007159 ABC transporter signature motif; other site 590998007160 Walker B; other site 590998007161 D-loop; other site 590998007162 H-loop/switch region; other site 590998007163 FtsX-like permease family; Region: FtsX; pfam02687 590998007164 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 590998007165 FtsX-like permease family; Region: FtsX; pfam02687 590998007166 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 590998007167 Transcription factor WhiB; Region: Whib; pfam02467 590998007168 Restriction endonuclease; Region: Mrr_cat; pfam04471 590998007169 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 590998007170 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 590998007171 Part of AAA domain; Region: AAA_19; pfam13245 590998007172 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 590998007173 Family description; Region: UvrD_C_2; pfam13538 590998007174 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 590998007175 AAA domain; Region: AAA_30; pfam13604 590998007176 Family description; Region: UvrD_C_2; pfam13538 590998007177 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998007178 Coenzyme A binding pocket [chemical binding]; other site 590998007179 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 590998007180 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 590998007181 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 590998007182 active site 590998007183 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 590998007184 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 590998007185 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 590998007186 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 590998007187 dimer interface [polypeptide binding]; other site 590998007188 Alkaline phosphatase homologues; Region: alkPPc; smart00098 590998007189 active site 590998007190 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 590998007191 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 590998007192 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 590998007193 tetramer interface [polypeptide binding]; other site 590998007194 active site 590998007195 Mg2+/Mn2+ binding site [ion binding]; other site 590998007196 citrate synthase; Provisional; Region: PRK14033 590998007197 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 590998007198 oxalacetate binding site [chemical binding]; other site 590998007199 citrylCoA binding site [chemical binding]; other site 590998007200 coenzyme A binding site [chemical binding]; other site 590998007201 catalytic triad [active] 590998007202 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 590998007203 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 590998007204 putative active site [active] 590998007205 putative catalytic site [active] 590998007206 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 590998007207 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 590998007208 active site 590998007209 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 590998007210 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 590998007211 ATP-grasp domain; Region: ATP-grasp_4; cl17255 590998007212 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 590998007213 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 590998007214 carboxyltransferase (CT) interaction site; other site 590998007215 biotinylation site [posttranslational modification]; other site 590998007216 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 590998007217 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 590998007218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998007219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998007220 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 590998007221 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 590998007222 TPP-binding site [chemical binding]; other site 590998007223 tetramer interface [polypeptide binding]; other site 590998007224 heterodimer interface [polypeptide binding]; other site 590998007225 phosphorylation loop region [posttranslational modification] 590998007226 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 590998007227 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 590998007228 alpha subunit interface [polypeptide binding]; other site 590998007229 TPP binding site [chemical binding]; other site 590998007230 heterodimer interface [polypeptide binding]; other site 590998007231 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 590998007232 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 590998007233 E3 interaction surface; other site 590998007234 lipoyl attachment site [posttranslational modification]; other site 590998007235 e3 binding domain; Region: E3_binding; pfam02817 590998007236 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 590998007237 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 590998007238 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 590998007239 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 590998007240 putative acyltransferase; Provisional; Region: PRK05790 590998007241 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 590998007242 dimer interface [polypeptide binding]; other site 590998007243 active site 590998007244 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 590998007245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998007246 Walker A/P-loop; other site 590998007247 ATP binding site [chemical binding]; other site 590998007248 ABC transporter signature motif; other site 590998007249 Walker B; other site 590998007250 D-loop; other site 590998007251 H-loop/switch region; other site 590998007252 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 590998007253 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 590998007254 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 590998007255 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 590998007256 catalytic loop [active] 590998007257 iron binding site [ion binding]; other site 590998007258 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 590998007259 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 590998007260 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 590998007261 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 590998007262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998007263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998007264 pyruvate dehydrogenase; Provisional; Region: PRK09124 590998007265 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 590998007266 PYR/PP interface [polypeptide binding]; other site 590998007267 dimer interface [polypeptide binding]; other site 590998007268 tetramer interface [polypeptide binding]; other site 590998007269 TPP binding site [chemical binding]; other site 590998007270 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 590998007271 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 590998007272 TPP-binding site [chemical binding]; other site 590998007273 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 590998007274 CoA binding domain; Region: CoA_binding_2; pfam13380 590998007275 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 590998007276 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 590998007277 active site 590998007278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998007279 Coenzyme A binding pocket [chemical binding]; other site 590998007280 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 590998007281 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 590998007282 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 590998007283 active site 590998007284 DNA binding site [nucleotide binding] 590998007285 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 590998007286 DNA binding site [nucleotide binding] 590998007287 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 590998007288 PGAP1-like protein; Region: PGAP1; pfam07819 590998007289 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 590998007290 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 590998007291 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 590998007292 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 590998007293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 590998007294 active site 590998007295 motif I; other site 590998007296 motif II; other site 590998007297 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 590998007298 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 590998007299 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 590998007300 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 590998007301 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 590998007302 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 590998007303 putative ADP-binding pocket [chemical binding]; other site 590998007304 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 590998007305 active site 590998007306 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 590998007307 substrate binding site [chemical binding]; other site 590998007308 ATP binding site [chemical binding]; other site 590998007309 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 590998007310 active site 590998007311 HIGH motif; other site 590998007312 nucleotide binding site [chemical binding]; other site 590998007313 classical (c) SDRs; Region: SDR_c; cd05233 590998007314 NAD(P) binding site [chemical binding]; other site 590998007315 active site 590998007316 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 590998007317 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 590998007318 putative active site [active] 590998007319 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 590998007320 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 590998007321 NAD binding site [chemical binding]; other site 590998007322 putative substrate binding site 2 [chemical binding]; other site 590998007323 putative substrate binding site 1 [chemical binding]; other site 590998007324 active site 590998007325 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 590998007326 SmpB-tmRNA interface; other site 590998007327 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 590998007328 Peptidase family M23; Region: Peptidase_M23; pfam01551 590998007329 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 590998007330 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 590998007331 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998007332 Walker A/P-loop; other site 590998007333 ATP binding site [chemical binding]; other site 590998007334 Q-loop/lid; other site 590998007335 ABC transporter signature motif; other site 590998007336 Walker B; other site 590998007337 D-loop; other site 590998007338 H-loop/switch region; other site 590998007339 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 590998007340 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 590998007341 Walker A/P-loop; other site 590998007342 ATP binding site [chemical binding]; other site 590998007343 Q-loop/lid; other site 590998007344 ABC transporter signature motif; other site 590998007345 Walker B; other site 590998007346 D-loop; other site 590998007347 H-loop/switch region; other site 590998007348 Transcriptional regulators [Transcription]; Region: MarR; COG1846 590998007349 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998007350 putative DNA binding site [nucleotide binding]; other site 590998007351 putative Zn2+ binding site [ion binding]; other site 590998007352 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 590998007353 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 590998007354 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 590998007355 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 590998007356 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 590998007357 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 590998007358 TM-ABC transporter signature motif; other site 590998007359 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 590998007360 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 590998007361 Walker A/P-loop; other site 590998007362 ATP binding site [chemical binding]; other site 590998007363 Q-loop/lid; other site 590998007364 ABC transporter signature motif; other site 590998007365 Walker B; other site 590998007366 D-loop; other site 590998007367 H-loop/switch region; other site 590998007368 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 590998007369 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 590998007370 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 590998007371 putative ligand binding site [chemical binding]; other site 590998007372 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998007373 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998007374 H+ Antiporter protein; Region: 2A0121; TIGR00900 590998007375 peptide chain release factor 2; Validated; Region: prfB; PRK00578 590998007376 This domain is found in peptide chain release factors; Region: PCRF; smart00937 590998007377 RF-1 domain; Region: RF-1; pfam00472 590998007378 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 590998007379 nudix motif; other site 590998007380 DNA polymerase IV; Validated; Region: PRK03858 590998007381 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 590998007382 active site 590998007383 DNA binding site [nucleotide binding] 590998007384 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 590998007385 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 590998007386 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 590998007387 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 590998007388 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 590998007389 ATP binding site [chemical binding]; other site 590998007390 Walker A motif; other site 590998007391 hexamer interface [polypeptide binding]; other site 590998007392 Walker B motif; other site 590998007393 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 590998007394 active site 590998007395 catalytic residues [active] 590998007396 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 590998007397 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 590998007398 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 590998007399 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 590998007400 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 590998007401 NAD(P) binding site [chemical binding]; other site 590998007402 acetoin reductases; Region: 23BDH; TIGR02415 590998007403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998007404 NAD(P) binding site [chemical binding]; other site 590998007405 active site 590998007406 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 590998007407 putative active site [active] 590998007408 putative catalytic site [active] 590998007409 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 590998007410 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 590998007411 dimer interface [polypeptide binding]; other site 590998007412 active site 590998007413 acyl-coenzyme A oxidase; Region: PLN02526 590998007414 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 590998007415 active site 590998007416 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 590998007417 active site 590998007418 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 590998007419 Phosphotransferase enzyme family; Region: APH; pfam01636 590998007420 putative active site [active] 590998007421 putative substrate binding site [chemical binding]; other site 590998007422 ATP binding site [chemical binding]; other site 590998007423 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 590998007424 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 590998007425 active site 590998007426 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 590998007427 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 590998007428 acyl-activating enzyme (AAE) consensus motif; other site 590998007429 putative AMP binding site [chemical binding]; other site 590998007430 putative active site [active] 590998007431 putative CoA binding site [chemical binding]; other site 590998007432 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 590998007433 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 590998007434 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 590998007435 TM-ABC transporter signature motif; other site 590998007436 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 590998007437 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 590998007438 Walker A/P-loop; other site 590998007439 ATP binding site [chemical binding]; other site 590998007440 Q-loop/lid; other site 590998007441 ABC transporter signature motif; other site 590998007442 Walker B; other site 590998007443 D-loop; other site 590998007444 H-loop/switch region; other site 590998007445 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 590998007446 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 590998007447 Walker A/P-loop; other site 590998007448 ATP binding site [chemical binding]; other site 590998007449 Q-loop/lid; other site 590998007450 ABC transporter signature motif; other site 590998007451 Walker B; other site 590998007452 D-loop; other site 590998007453 H-loop/switch region; other site 590998007454 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 590998007455 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 590998007456 Sulfate transporter family; Region: Sulfate_transp; pfam00916 590998007457 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 590998007458 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998007459 dimerization interface [polypeptide binding]; other site 590998007460 putative DNA binding site [nucleotide binding]; other site 590998007461 putative Zn2+ binding site [ion binding]; other site 590998007462 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 590998007463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998007464 NAD(P) binding site [chemical binding]; other site 590998007465 active site 590998007466 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 590998007467 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 590998007468 NAD(P) binding site [chemical binding]; other site 590998007469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998007470 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998007471 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 590998007472 classical (c) SDRs; Region: SDR_c; cd05233 590998007473 NAD(P) binding site [chemical binding]; other site 590998007474 active site 590998007475 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 590998007476 active site 590998007477 catalytic residues [active] 590998007478 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 590998007479 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 590998007480 Domain of unknown function DUF21; Region: DUF21; pfam01595 590998007481 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 590998007482 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 590998007483 Domain of unknown function DUF21; Region: DUF21; pfam01595 590998007484 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 590998007485 Transporter associated domain; Region: CorC_HlyC; smart01091 590998007486 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 590998007487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998007488 active site 590998007489 phosphorylation site [posttranslational modification] 590998007490 intermolecular recognition site; other site 590998007491 dimerization interface [polypeptide binding]; other site 590998007492 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 590998007493 DNA binding site [nucleotide binding] 590998007494 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 590998007495 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 590998007496 dimerization interface [polypeptide binding]; other site 590998007497 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 590998007498 dimer interface [polypeptide binding]; other site 590998007499 phosphorylation site [posttranslational modification] 590998007500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998007501 ATP binding site [chemical binding]; other site 590998007502 Mg2+ binding site [ion binding]; other site 590998007503 G-X-G motif; other site 590998007504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998007505 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 590998007506 Walker A/P-loop; other site 590998007507 ATP binding site [chemical binding]; other site 590998007508 Q-loop/lid; other site 590998007509 ABC transporter signature motif; other site 590998007510 Walker B; other site 590998007511 D-loop; other site 590998007512 H-loop/switch region; other site 590998007513 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 590998007514 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 590998007515 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 590998007516 TPP-binding site [chemical binding]; other site 590998007517 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 590998007518 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 590998007519 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 590998007520 conserved cys residue [active] 590998007521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 590998007522 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 590998007523 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 590998007524 active site 590998007525 catalytic triad [active] 590998007526 oxyanion hole [active] 590998007527 Predicted transcriptional regulators [Transcription]; Region: COG1695 590998007528 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 590998007529 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 590998007530 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 590998007531 Walker A motif; other site 590998007532 ATP binding site [chemical binding]; other site 590998007533 Walker B motif; other site 590998007534 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 590998007535 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 590998007536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998007537 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 590998007538 DNA binding residues [nucleotide binding] 590998007539 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 590998007540 Ferritin-like domain; Region: Ferritin; pfam00210 590998007541 ferroxidase diiron center [ion binding]; other site 590998007542 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 590998007543 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 590998007544 hinge; other site 590998007545 active site 590998007546 ribosome small subunit-dependent GTPase A; Region: TIGR00157 590998007547 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 590998007548 GTPase/Zn-binding domain interface [polypeptide binding]; other site 590998007549 GTP/Mg2+ binding site [chemical binding]; other site 590998007550 G4 box; other site 590998007551 G5 box; other site 590998007552 G1 box; other site 590998007553 Switch I region; other site 590998007554 G2 box; other site 590998007555 G3 box; other site 590998007556 Switch II region; other site 590998007557 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 590998007558 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 590998007559 active site 590998007560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998007561 S-adenosylmethionine binding site [chemical binding]; other site 590998007562 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 590998007563 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 590998007564 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 590998007565 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 590998007566 HIGH motif; other site 590998007567 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 590998007568 active site 590998007569 KMSKS motif; other site 590998007570 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 590998007571 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 590998007572 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 590998007573 Methyltransferase domain; Region: Methyltransf_31; pfam13847 590998007574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998007575 S-adenosylmethionine binding site [chemical binding]; other site 590998007576 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 590998007577 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 590998007578 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 590998007579 DXD motif; other site 590998007580 Right handed beta helix region; Region: Beta_helix; pfam13229 590998007581 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 590998007582 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 590998007583 catalytic triad [active] 590998007584 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 590998007585 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 590998007586 ATP binding site [chemical binding]; other site 590998007587 putative Mg++ binding site [ion binding]; other site 590998007588 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 590998007589 nucleotide binding region [chemical binding]; other site 590998007590 ATP-binding site [chemical binding]; other site 590998007591 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 590998007592 CCC1-related family of proteins; Region: CCC1_like; cl00278 590998007593 CCC1-related family of proteins; Region: CCC1_like; cl00278 590998007594 hypothetical protein; Provisional; Region: PRK11770 590998007595 Domain of unknown function (DUF307); Region: DUF307; pfam03733 590998007596 Domain of unknown function (DUF307); Region: DUF307; pfam03733 590998007597 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 590998007598 putative deacylase active site [active] 590998007599 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 590998007600 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 590998007601 catalytic residue [active] 590998007602 Domain of unknown function (DUF202); Region: DUF202; cl09954 590998007603 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 590998007604 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 590998007605 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 590998007606 active site 590998007607 catalytic residues [active] 590998007608 metal binding site [ion binding]; metal-binding site 590998007609 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 590998007610 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 590998007611 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 590998007612 homodimer interface [polypeptide binding]; other site 590998007613 substrate-cofactor binding pocket; other site 590998007614 catalytic residue [active] 590998007615 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 590998007616 tartrate dehydrogenase; Region: TTC; TIGR02089 590998007617 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 590998007618 ketol-acid reductoisomerase; Provisional; Region: PRK05479 590998007619 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 590998007620 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 590998007621 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 590998007622 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 590998007623 putative valine binding site [chemical binding]; other site 590998007624 dimer interface [polypeptide binding]; other site 590998007625 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 590998007626 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 590998007627 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 590998007628 PYR/PP interface [polypeptide binding]; other site 590998007629 dimer interface [polypeptide binding]; other site 590998007630 TPP binding site [chemical binding]; other site 590998007631 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 590998007632 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 590998007633 TPP-binding site [chemical binding]; other site 590998007634 dimer interface [polypeptide binding]; other site 590998007635 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 590998007636 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998007637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998007638 active site 590998007639 phosphorylation site [posttranslational modification] 590998007640 intermolecular recognition site; other site 590998007641 dimerization interface [polypeptide binding]; other site 590998007642 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998007643 DNA binding residues [nucleotide binding] 590998007644 dimerization interface [polypeptide binding]; other site 590998007645 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 590998007646 Histidine kinase; Region: HisKA_3; pfam07730 590998007647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998007648 ATP binding site [chemical binding]; other site 590998007649 Mg2+ binding site [ion binding]; other site 590998007650 G-X-G motif; other site 590998007651 Domain of unknown function (DUF385); Region: DUF385; cl04387 590998007652 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 590998007653 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 590998007654 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 590998007655 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 590998007656 Walker A/P-loop; other site 590998007657 ATP binding site [chemical binding]; other site 590998007658 Q-loop/lid; other site 590998007659 ABC transporter signature motif; other site 590998007660 Walker B; other site 590998007661 D-loop; other site 590998007662 H-loop/switch region; other site 590998007663 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 590998007664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998007665 Walker A/P-loop; other site 590998007666 ATP binding site [chemical binding]; other site 590998007667 Q-loop/lid; other site 590998007668 ABC transporter signature motif; other site 590998007669 Walker B; other site 590998007670 D-loop; other site 590998007671 H-loop/switch region; other site 590998007672 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 590998007673 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 590998007674 Ca binding site [ion binding]; other site 590998007675 active site 590998007676 catalytic site [active] 590998007677 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998007678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998007679 dimer interface [polypeptide binding]; other site 590998007680 conserved gate region; other site 590998007681 putative PBP binding loops; other site 590998007682 ABC-ATPase subunit interface; other site 590998007683 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 590998007684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998007685 dimer interface [polypeptide binding]; other site 590998007686 conserved gate region; other site 590998007687 putative PBP binding loops; other site 590998007688 ABC-ATPase subunit interface; other site 590998007689 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998007690 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 590998007691 Melibiase; Region: Melibiase; pfam02065 590998007692 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998007693 putative DNA binding site [nucleotide binding]; other site 590998007694 putative Zn2+ binding site [ion binding]; other site 590998007695 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 590998007696 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 590998007697 Transcriptional regulators [Transcription]; Region: MarR; COG1846 590998007698 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 590998007699 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 590998007700 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 590998007701 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 590998007702 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 590998007703 metal binding site [ion binding]; metal-binding site 590998007704 active site 590998007705 I-site; other site 590998007706 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 590998007707 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 590998007708 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 590998007709 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 590998007710 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 590998007711 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998007712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998007713 dimer interface [polypeptide binding]; other site 590998007714 conserved gate region; other site 590998007715 putative PBP binding loops; other site 590998007716 ABC-ATPase subunit interface; other site 590998007717 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 590998007718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998007719 dimer interface [polypeptide binding]; other site 590998007720 conserved gate region; other site 590998007721 putative PBP binding loops; other site 590998007722 ABC-ATPase subunit interface; other site 590998007723 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998007724 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 590998007725 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998007726 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998007727 DNA binding site [nucleotide binding] 590998007728 domain linker motif; other site 590998007729 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 590998007730 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 590998007731 substrate binding site [chemical binding]; other site 590998007732 aromatic arch; other site 590998007733 DCoH dimer interaction site [polypeptide binding]; other site 590998007734 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 590998007735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998007736 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 590998007737 DNA photolyase; Region: DNA_photolyase; pfam00875 590998007738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998007739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998007740 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 590998007741 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 590998007742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998007743 Coenzyme A binding pocket [chemical binding]; other site 590998007744 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 590998007745 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 590998007746 GatB domain; Region: GatB_Yqey; smart00845 590998007747 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 590998007748 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 590998007749 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 590998007750 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 590998007751 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 590998007752 oligomeric interface; other site 590998007753 putative active site [active] 590998007754 homodimer interface [polypeptide binding]; other site 590998007755 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 590998007756 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 590998007757 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 590998007758 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 590998007759 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 590998007760 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 590998007761 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 590998007762 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 590998007763 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 590998007764 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 590998007765 TM-ABC transporter signature motif; other site 590998007766 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 590998007767 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 590998007768 Walker A/P-loop; other site 590998007769 ATP binding site [chemical binding]; other site 590998007770 Q-loop/lid; other site 590998007771 ABC transporter signature motif; other site 590998007772 Walker B; other site 590998007773 D-loop; other site 590998007774 H-loop/switch region; other site 590998007775 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 590998007776 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 590998007777 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 590998007778 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 590998007779 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 590998007780 Ligase N family; Region: LIGANc; smart00532 590998007781 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 590998007782 nucleotide binding pocket [chemical binding]; other site 590998007783 K-X-D-G motif; other site 590998007784 catalytic site [active] 590998007785 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 590998007786 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 590998007787 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 590998007788 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 590998007789 Dimer interface [polypeptide binding]; other site 590998007790 BRCT sequence motif; other site 590998007791 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 590998007792 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 590998007793 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 590998007794 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 590998007795 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 590998007796 catalytic residue [active] 590998007797 Phosphotransferase enzyme family; Region: APH; pfam01636 590998007798 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 590998007799 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 590998007800 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 590998007801 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 590998007802 Ligand binding site [chemical binding]; other site 590998007803 Electron transfer flavoprotein domain; Region: ETF; pfam01012 590998007804 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 590998007805 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 590998007806 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 590998007807 active site 590998007808 catalytic site [active] 590998007809 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 590998007810 hypothetical protein; Validated; Region: PRK07121 590998007811 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 590998007812 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 590998007813 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 590998007814 active site 590998007815 homodimer interface [polypeptide binding]; other site 590998007816 catalytic site [active] 590998007817 acceptor binding site [chemical binding]; other site 590998007818 trehalose synthase; Region: treS_nterm; TIGR02456 590998007819 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 590998007820 active site 590998007821 catalytic site [active] 590998007822 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 590998007823 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 590998007824 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 590998007825 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 590998007826 nucleotide binding site [chemical binding]; other site 590998007827 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998007828 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 590998007829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998007830 dimer interface [polypeptide binding]; other site 590998007831 conserved gate region; other site 590998007832 putative PBP binding loops; other site 590998007833 ABC-ATPase subunit interface; other site 590998007834 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998007835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 590998007836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998007837 putative PBP binding loops; other site 590998007838 dimer interface [polypeptide binding]; other site 590998007839 ABC-ATPase subunit interface; other site 590998007840 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 590998007841 Melibiase; Region: Melibiase; pfam02065 590998007842 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 590998007843 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 590998007844 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 590998007845 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 590998007846 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998007847 ligand binding site [chemical binding]; other site 590998007848 dimerization interface [polypeptide binding]; other site 590998007849 glycogen branching enzyme; Provisional; Region: PRK05402 590998007850 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 590998007851 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 590998007852 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 590998007853 active site 590998007854 catalytic site [active] 590998007855 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 590998007856 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 590998007857 nucleotide binding site/active site [active] 590998007858 HIT family signature motif; other site 590998007859 catalytic residue [active] 590998007860 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 590998007861 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 590998007862 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 590998007863 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 590998007864 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 590998007865 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 590998007866 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 590998007867 beta-galactosidase; Region: BGL; TIGR03356 590998007868 putative alpha-glucosidase; Provisional; Region: PRK10658 590998007869 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 590998007870 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 590998007871 active site 590998007872 homotrimer interface [polypeptide binding]; other site 590998007873 catalytic site [active] 590998007874 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 590998007875 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 590998007876 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 590998007877 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 590998007878 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998007879 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998007880 DNA binding site [nucleotide binding] 590998007881 domain linker motif; other site 590998007882 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998007883 dimerization interface [polypeptide binding]; other site 590998007884 ligand binding site [chemical binding]; other site 590998007885 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998007886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998007887 dimer interface [polypeptide binding]; other site 590998007888 conserved gate region; other site 590998007889 putative PBP binding loops; other site 590998007890 ABC-ATPase subunit interface; other site 590998007891 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 590998007892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998007893 dimer interface [polypeptide binding]; other site 590998007894 conserved gate region; other site 590998007895 ABC-ATPase subunit interface; other site 590998007896 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998007897 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 590998007898 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 590998007899 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 590998007900 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 590998007901 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 590998007902 active site 590998007903 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 590998007904 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998007905 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998007906 hypothetical protein; Provisional; Region: PRK03298 590998007907 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 590998007908 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 590998007909 gamma subunit interface [polypeptide binding]; other site 590998007910 LBP interface [polypeptide binding]; other site 590998007911 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 590998007912 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 590998007913 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 590998007914 alpha subunit interaction interface [polypeptide binding]; other site 590998007915 Walker A motif; other site 590998007916 ATP binding site [chemical binding]; other site 590998007917 Walker B motif; other site 590998007918 inhibitor binding site; inhibition site 590998007919 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 590998007920 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 590998007921 core domain interface [polypeptide binding]; other site 590998007922 delta subunit interface [polypeptide binding]; other site 590998007923 epsilon subunit interface [polypeptide binding]; other site 590998007924 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 590998007925 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 590998007926 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 590998007927 beta subunit interaction interface [polypeptide binding]; other site 590998007928 Walker A motif; other site 590998007929 ATP binding site [chemical binding]; other site 590998007930 Walker B motif; other site 590998007931 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 590998007932 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 590998007933 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 590998007934 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 590998007935 ATP synthase subunit C; Region: ATP-synt_C; cl00466 590998007936 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 590998007937 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 590998007938 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 590998007939 Mg++ binding site [ion binding]; other site 590998007940 putative catalytic motif [active] 590998007941 substrate binding site [chemical binding]; other site 590998007942 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 590998007943 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 590998007944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 590998007945 This domain is found in peptide chain release factors; Region: PCRF; smart00937 590998007946 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 590998007947 RF-1 domain; Region: RF-1; pfam00472 590998007948 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 590998007949 META domain; Region: META; pfam03724 590998007950 TfoX N-terminal domain; Region: TfoX_N; cl17592 590998007951 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 590998007952 transcription termination factor Rho; Provisional; Region: PRK12608 590998007953 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 590998007954 RNA binding site [nucleotide binding]; other site 590998007955 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 590998007956 multimer interface [polypeptide binding]; other site 590998007957 Walker A motif; other site 590998007958 ATP binding site [chemical binding]; other site 590998007959 Walker B motif; other site 590998007960 homoserine kinase; Provisional; Region: PRK01212 590998007961 threonine synthase; Reviewed; Region: PRK06721 590998007962 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 590998007963 homodimer interface [polypeptide binding]; other site 590998007964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998007965 catalytic residue [active] 590998007966 homoserine dehydrogenase; Provisional; Region: PRK06349 590998007967 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 590998007968 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 590998007969 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 590998007970 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 590998007971 heme binding pocket [chemical binding]; other site 590998007972 heme ligand [chemical binding]; other site 590998007973 diaminopimelate decarboxylase; Region: lysA; TIGR01048 590998007974 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 590998007975 active site 590998007976 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 590998007977 substrate binding site [chemical binding]; other site 590998007978 catalytic residues [active] 590998007979 dimer interface [polypeptide binding]; other site 590998007980 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 590998007981 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 590998007982 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 590998007983 active site 590998007984 HIGH motif; other site 590998007985 KMSK motif region; other site 590998007986 tRNA binding surface [nucleotide binding]; other site 590998007987 DALR anticodon binding domain; Region: DALR_1; smart00836 590998007988 anticodon binding site; other site 590998007989 Transcriptional regulators [Transcription]; Region: FadR; COG2186 590998007990 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 590998007991 DNA-binding site [nucleotide binding]; DNA binding site 590998007992 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 590998007993 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 590998007994 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 590998007995 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 590998007996 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 590998007997 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 590998007998 non-specific DNA binding site [nucleotide binding]; other site 590998007999 salt bridge; other site 590998008000 sequence-specific DNA binding site [nucleotide binding]; other site 590998008001 Domain of unknown function (DUF955); Region: DUF955; pfam06114 590998008002 isocitrate lyase; Provisional; Region: PRK15063 590998008003 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 590998008004 tetramer interface [polypeptide binding]; other site 590998008005 active site 590998008006 Mg2+/Mn2+ binding site [ion binding]; other site 590998008007 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 590998008008 malate synthase A; Region: malate_syn_A; TIGR01344 590998008009 active site 590998008010 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 590998008011 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 590998008012 putative catalytic cysteine [active] 590998008013 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 590998008014 putative active site [active] 590998008015 metal binding site [ion binding]; metal-binding site 590998008016 aminotransferase; Validated; Region: PRK07777 590998008017 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 590998008018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998008019 homodimer interface [polypeptide binding]; other site 590998008020 catalytic residue [active] 590998008021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998008022 putative substrate translocation pore; other site 590998008023 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 590998008024 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 590998008025 cyclase homology domain; Region: CHD; cd07302 590998008026 nucleotidyl binding site; other site 590998008027 metal binding site [ion binding]; metal-binding site 590998008028 dimer interface [polypeptide binding]; other site 590998008029 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 590998008030 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 590998008031 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 590998008032 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 590998008033 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 590998008034 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 590998008035 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 590998008036 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 590998008037 putative active site [active] 590998008038 redox center [active] 590998008039 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 590998008040 active site 590998008041 dimer interface [polypeptide binding]; other site 590998008042 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 590998008043 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 590998008044 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 590998008045 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 590998008046 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 590998008047 carboxyltransferase (CT) interaction site; other site 590998008048 biotinylation site [posttranslational modification]; other site 590998008049 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 590998008050 nudix motif; other site 590998008051 Iron permease FTR1 family; Region: FTR1; cl00475 590998008052 Imelysin; Region: Peptidase_M75; pfam09375 590998008053 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 590998008054 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 590998008055 putative catalytic site [active] 590998008056 putative metal binding site [ion binding]; other site 590998008057 putative catalytic site [active] 590998008058 putative phosphate binding site [ion binding]; other site 590998008059 putative phosphate binding site [ion binding]; other site 590998008060 putative metal binding site [ion binding]; other site 590998008061 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 590998008062 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 590998008063 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 590998008064 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 590998008065 purine nucleoside phosphorylase; Provisional; Region: PRK08202 590998008066 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 590998008067 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 590998008068 active site 590998008069 substrate binding site [chemical binding]; other site 590998008070 metal binding site [ion binding]; metal-binding site 590998008071 Cellulose binding domain; Region: CBM_2; pfam00553 590998008072 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 590998008073 intersubunit interface [polypeptide binding]; other site 590998008074 active site 590998008075 catalytic residue [active] 590998008076 adenosine deaminase; Provisional; Region: PRK09358 590998008077 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 590998008078 active site 590998008079 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 590998008080 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 590998008081 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 590998008082 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 590998008083 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 590998008084 active site 590998008085 catalytic motif [active] 590998008086 Zn binding site [ion binding]; other site 590998008087 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 590998008088 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 590998008089 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 590998008090 TM-ABC transporter signature motif; other site 590998008091 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 590998008092 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 590998008093 TM-ABC transporter signature motif; other site 590998008094 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 590998008095 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 590998008096 Walker A/P-loop; other site 590998008097 ATP binding site [chemical binding]; other site 590998008098 Q-loop/lid; other site 590998008099 ABC transporter signature motif; other site 590998008100 Walker B; other site 590998008101 D-loop; other site 590998008102 H-loop/switch region; other site 590998008103 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 590998008104 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 590998008105 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 590998008106 ligand binding site [chemical binding]; other site 590998008107 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 590998008108 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 590998008109 metal binding site [ion binding]; metal-binding site 590998008110 putative dimer interface [polypeptide binding]; other site 590998008111 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 590998008112 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 590998008113 active site 590998008114 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 590998008115 putative Iron-sulfur protein interface [polypeptide binding]; other site 590998008116 putative proximal heme binding site [chemical binding]; other site 590998008117 putative SdhD-like interface [polypeptide binding]; other site 590998008118 putative distal heme binding site [chemical binding]; other site 590998008119 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 590998008120 putative Iron-sulfur protein interface [polypeptide binding]; other site 590998008121 putative proximal heme binding site [chemical binding]; other site 590998008122 putative SdhC-like subunit interface [polypeptide binding]; other site 590998008123 putative distal heme binding site [chemical binding]; other site 590998008124 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 590998008125 L-aspartate oxidase; Provisional; Region: PRK06175 590998008126 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 590998008127 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 590998008128 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 590998008129 catalytic loop [active] 590998008130 iron binding site [ion binding]; other site 590998008131 transposase; Provisional; Region: PRK06526 590998008132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 590998008133 Walker A motif; other site 590998008134 ATP binding site [chemical binding]; other site 590998008135 Walker B motif; other site 590998008136 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 590998008137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 590998008138 DNA-binding interface [nucleotide binding]; DNA binding site 590998008139 Integrase core domain; Region: rve; pfam00665 590998008140 Integrase core domain; Region: rve_3; cl15866 590998008141 Phosphotransferase enzyme family; Region: APH; pfam01636 590998008142 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 590998008143 active site 590998008144 ATP binding site [chemical binding]; other site 590998008145 substrate binding site [chemical binding]; other site 590998008146 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 590998008147 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 590998008148 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 590998008149 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 590998008150 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 590998008151 active site 590998008152 HIGH motif; other site 590998008153 dimer interface [polypeptide binding]; other site 590998008154 KMSKS motif; other site 590998008155 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 590998008156 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 590998008157 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 590998008158 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998008159 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 590998008160 DNA binding residues [nucleotide binding] 590998008161 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 590998008162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998008163 S-adenosylmethionine binding site [chemical binding]; other site 590998008164 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 590998008165 multifunctional aminopeptidase A; Provisional; Region: PRK00913 590998008166 interface (dimer of trimers) [polypeptide binding]; other site 590998008167 Substrate-binding/catalytic site; other site 590998008168 Zn-binding sites [ion binding]; other site 590998008169 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 590998008170 dihydropteroate synthase; Region: DHPS; TIGR01496 590998008171 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 590998008172 substrate binding pocket [chemical binding]; other site 590998008173 dimer interface [polypeptide binding]; other site 590998008174 inhibitor binding site; inhibition site 590998008175 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 590998008176 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 590998008177 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 590998008178 metal binding site [ion binding]; metal-binding site 590998008179 putative dimer interface [polypeptide binding]; other site 590998008180 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 590998008181 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 590998008182 putative trimer interface [polypeptide binding]; other site 590998008183 putative CoA binding site [chemical binding]; other site 590998008184 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 590998008185 dimer interface [polypeptide binding]; other site 590998008186 Citrate synthase; Region: Citrate_synt; pfam00285 590998008187 active site 590998008188 citrylCoA binding site [chemical binding]; other site 590998008189 NADH binding [chemical binding]; other site 590998008190 cationic pore residues; other site 590998008191 oxalacetate/citrate binding site [chemical binding]; other site 590998008192 coenzyme A binding site [chemical binding]; other site 590998008193 catalytic triad [active] 590998008194 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 590998008195 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 590998008196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998008197 homodimer interface [polypeptide binding]; other site 590998008198 catalytic residue [active] 590998008199 Ferredoxin [Energy production and conversion]; Region: COG1146 590998008200 4Fe-4S binding domain; Region: Fer4; pfam00037 590998008201 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 590998008202 VanW like protein; Region: VanW; pfam04294 590998008203 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 590998008204 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 590998008205 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 590998008206 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 590998008207 G1 box; other site 590998008208 putative GEF interaction site [polypeptide binding]; other site 590998008209 GTP/Mg2+ binding site [chemical binding]; other site 590998008210 Switch I region; other site 590998008211 G2 box; other site 590998008212 G3 box; other site 590998008213 Switch II region; other site 590998008214 G4 box; other site 590998008215 G5 box; other site 590998008216 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 590998008217 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 590998008218 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 590998008219 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 590998008220 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 590998008221 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 590998008222 Walker A/P-loop; other site 590998008223 ATP binding site [chemical binding]; other site 590998008224 Q-loop/lid; other site 590998008225 ABC transporter signature motif; other site 590998008226 Walker B; other site 590998008227 D-loop; other site 590998008228 H-loop/switch region; other site 590998008229 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 590998008230 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 590998008231 Walker A/P-loop; other site 590998008232 ATP binding site [chemical binding]; other site 590998008233 Q-loop/lid; other site 590998008234 ABC transporter signature motif; other site 590998008235 Walker B; other site 590998008236 D-loop; other site 590998008237 H-loop/switch region; other site 590998008238 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 590998008239 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 590998008240 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 590998008241 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 590998008242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998008243 dimer interface [polypeptide binding]; other site 590998008244 conserved gate region; other site 590998008245 putative PBP binding loops; other site 590998008246 ABC-ATPase subunit interface; other site 590998008247 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 590998008248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 590998008249 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 590998008250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998008251 putative PBP binding loops; other site 590998008252 dimer interface [polypeptide binding]; other site 590998008253 ABC-ATPase subunit interface; other site 590998008254 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 590998008255 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 590998008256 Domain of unknown function (DUF385); Region: DUF385; pfam04075 590998008257 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 590998008258 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 590998008259 Helix-turn-helix domain; Region: HTH_31; pfam13560 590998008260 short chain dehydrogenase; Provisional; Region: PRK05854 590998008261 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 590998008262 putative NAD(P) binding site [chemical binding]; other site 590998008263 active site 590998008264 GTP-binding protein YchF; Reviewed; Region: PRK09601 590998008265 YchF GTPase; Region: YchF; cd01900 590998008266 G1 box; other site 590998008267 GTP/Mg2+ binding site [chemical binding]; other site 590998008268 Switch I region; other site 590998008269 G2 box; other site 590998008270 Switch II region; other site 590998008271 G3 box; other site 590998008272 G4 box; other site 590998008273 G5 box; other site 590998008274 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 590998008275 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 590998008276 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 590998008277 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 590998008278 Walker A/P-loop; other site 590998008279 ATP binding site [chemical binding]; other site 590998008280 Q-loop/lid; other site 590998008281 ABC transporter signature motif; other site 590998008282 Walker B; other site 590998008283 D-loop; other site 590998008284 H-loop/switch region; other site 590998008285 RmuC family; Region: RmuC; pfam02646 590998008286 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 590998008287 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 590998008288 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 590998008289 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 590998008290 generic binding surface II; other site 590998008291 generic binding surface I; other site 590998008292 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 590998008293 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 590998008294 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 590998008295 putative substrate binding site [chemical binding]; other site 590998008296 putative ATP binding site [chemical binding]; other site 590998008297 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 590998008298 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 590998008299 Walker A/P-loop; other site 590998008300 ATP binding site [chemical binding]; other site 590998008301 Q-loop/lid; other site 590998008302 ABC transporter signature motif; other site 590998008303 Walker B; other site 590998008304 D-loop; other site 590998008305 H-loop/switch region; other site 590998008306 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998008307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998008308 dimer interface [polypeptide binding]; other site 590998008309 conserved gate region; other site 590998008310 ABC-ATPase subunit interface; other site 590998008311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998008312 dimer interface [polypeptide binding]; other site 590998008313 conserved gate region; other site 590998008314 putative PBP binding loops; other site 590998008315 ABC-ATPase subunit interface; other site 590998008316 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998008317 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 590998008318 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 590998008319 active site clefts [active] 590998008320 zinc binding site [ion binding]; other site 590998008321 dimer interface [polypeptide binding]; other site 590998008322 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 590998008323 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 590998008324 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 590998008325 Walker A/P-loop; other site 590998008326 ATP binding site [chemical binding]; other site 590998008327 Q-loop/lid; other site 590998008328 ABC transporter signature motif; other site 590998008329 Walker B; other site 590998008330 D-loop; other site 590998008331 H-loop/switch region; other site 590998008332 fumarate hydratase; Reviewed; Region: fumC; PRK00485 590998008333 Class II fumarases; Region: Fumarase_classII; cd01362 590998008334 active site 590998008335 tetramer interface [polypeptide binding]; other site 590998008336 RibD C-terminal domain; Region: RibD_C; cl17279 590998008337 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 590998008338 Major Facilitator Superfamily; Region: MFS_1; pfam07690 590998008339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998008340 putative substrate translocation pore; other site 590998008341 Transcriptional regulator PadR-like family; Region: PadR; cl17335 590998008342 Predicted transcriptional regulators [Transcription]; Region: COG1695 590998008343 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 590998008344 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 590998008345 Walker A/P-loop; other site 590998008346 ATP binding site [chemical binding]; other site 590998008347 Q-loop/lid; other site 590998008348 ABC transporter signature motif; other site 590998008349 Walker B; other site 590998008350 D-loop; other site 590998008351 H-loop/switch region; other site 590998008352 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 590998008353 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 590998008354 Walker A/P-loop; other site 590998008355 ATP binding site [chemical binding]; other site 590998008356 Q-loop/lid; other site 590998008357 ABC transporter signature motif; other site 590998008358 Walker B; other site 590998008359 D-loop; other site 590998008360 H-loop/switch region; other site 590998008361 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 590998008362 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 590998008363 putative active site [active] 590998008364 PhoH-like protein; Region: PhoH; pfam02562 590998008365 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 590998008366 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 590998008367 catalytic residue [active] 590998008368 putative FPP diphosphate binding site; other site 590998008369 putative FPP binding hydrophobic cleft; other site 590998008370 dimer interface [polypeptide binding]; other site 590998008371 putative IPP diphosphate binding site; other site 590998008372 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 590998008373 Haemolysin-III related; Region: HlyIII; pfam03006 590998008374 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 590998008375 Predicted amidohydrolase [General function prediction only]; Region: COG0388 590998008376 active site 590998008377 catalytic triad [active] 590998008378 dimer interface [polypeptide binding]; other site 590998008379 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 590998008380 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 590998008381 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 590998008382 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 590998008383 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 590998008384 threonine dehydratase; Provisional; Region: PRK08198 590998008385 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 590998008386 tetramer interface [polypeptide binding]; other site 590998008387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998008388 catalytic residue [active] 590998008389 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 590998008390 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 590998008391 Domain of unknown function DUF20; Region: UPF0118; pfam01594 590998008392 cystathionine gamma-synthase; Provisional; Region: PRK07811 590998008393 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 590998008394 homodimer interface [polypeptide binding]; other site 590998008395 substrate-cofactor binding pocket; other site 590998008396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998008397 catalytic residue [active] 590998008398 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 590998008399 Rdx family; Region: Rdx; cl01407 590998008400 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 590998008401 FAD binding domain; Region: FAD_binding_4; pfam01565 590998008402 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 590998008403 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 590998008404 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 590998008405 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 590998008406 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 590998008407 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 590998008408 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 590998008409 acyl-activating enzyme (AAE) consensus motif; other site 590998008410 putative AMP binding site [chemical binding]; other site 590998008411 putative active site [active] 590998008412 putative CoA binding site [chemical binding]; other site 590998008413 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 590998008414 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 590998008415 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 590998008416 dimer interface [polypeptide binding]; other site 590998008417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998008418 catalytic residue [active] 590998008419 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 590998008420 Bax inhibitor 1 like; Region: BaxI_1; cl17691 590998008421 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 590998008422 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 590998008423 Walker A/P-loop; other site 590998008424 ATP binding site [chemical binding]; other site 590998008425 Q-loop/lid; other site 590998008426 ABC transporter signature motif; other site 590998008427 Walker B; other site 590998008428 D-loop; other site 590998008429 H-loop/switch region; other site 590998008430 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 590998008431 MarR family; Region: MarR_2; pfam12802 590998008432 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 590998008433 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 590998008434 FAD binding pocket [chemical binding]; other site 590998008435 FAD binding motif [chemical binding]; other site 590998008436 phosphate binding motif [ion binding]; other site 590998008437 NAD binding pocket [chemical binding]; other site 590998008438 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 590998008439 Transposase; Region: HTH_Tnp_1; cl17663 590998008440 Transcriptional regulator [Transcription]; Region: LysR; COG0583 590998008441 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 590998008442 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 590998008443 substrate binding pocket [chemical binding]; other site 590998008444 dimerization interface [polypeptide binding]; other site 590998008445 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998008446 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998008447 DNA binding site [nucleotide binding] 590998008448 domain linker motif; other site 590998008449 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998008450 dimerization interface [polypeptide binding]; other site 590998008451 ligand binding site [chemical binding]; other site 590998008452 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998008453 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 590998008454 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 590998008455 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998008456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998008457 dimer interface [polypeptide binding]; other site 590998008458 conserved gate region; other site 590998008459 putative PBP binding loops; other site 590998008460 ABC-ATPase subunit interface; other site 590998008461 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 590998008462 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 590998008463 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 590998008464 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 590998008465 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 590998008466 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 590998008467 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 590998008468 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 590998008469 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 590998008470 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 590998008471 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 590998008472 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 590998008473 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 590998008474 TM-ABC transporter signature motif; other site 590998008475 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 590998008476 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998008477 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 590998008478 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 590998008479 TM-ABC transporter signature motif; other site 590998008480 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 590998008481 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 590998008482 Walker A/P-loop; other site 590998008483 ATP binding site [chemical binding]; other site 590998008484 Q-loop/lid; other site 590998008485 ABC transporter signature motif; other site 590998008486 Walker B; other site 590998008487 D-loop; other site 590998008488 H-loop/switch region; other site 590998008489 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 590998008490 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998008491 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998008492 DNA binding site [nucleotide binding] 590998008493 domain linker motif; other site 590998008494 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998008495 dimerization interface [polypeptide binding]; other site 590998008496 ligand binding site [chemical binding]; other site 590998008497 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 590998008498 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 590998008499 active site 590998008500 NAD binding site [chemical binding]; other site 590998008501 metal binding site [ion binding]; metal-binding site 590998008502 short chain dehydrogenase; Validated; Region: PRK08324 590998008503 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 590998008504 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 590998008505 putative NAD(P) binding site [chemical binding]; other site 590998008506 active site 590998008507 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 590998008508 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 590998008509 active site 590998008510 substrate binding site [chemical binding]; other site 590998008511 FMN binding site [chemical binding]; other site 590998008512 putative catalytic residues [active] 590998008513 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 590998008514 dimer interface [polypeptide binding]; other site 590998008515 putative CheW interface [polypeptide binding]; other site 590998008516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998008517 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 590998008518 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 590998008519 Cupin domain; Region: Cupin_2; pfam07883 590998008520 Cupin domain; Region: Cupin_2; cl17218 590998008521 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 590998008522 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 590998008523 Putative cyclase; Region: Cyclase; pfam04199 590998008524 hypothetical protein; Provisional; Region: PRK06847 590998008525 hypothetical protein; Provisional; Region: PRK07236 590998008526 Amidohydrolase; Region: Amidohydro_2; pfam04909 590998008527 Transcriptional regulator [Transcription]; Region: LysR; COG0583 590998008528 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 590998008529 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 590998008530 substrate binding pocket [chemical binding]; other site 590998008531 dimerization interface [polypeptide binding]; other site 590998008532 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 590998008533 dimer interface [polypeptide binding]; other site 590998008534 Thiolase, N-terminal domain; Region: Thiolase_N; pfam00108 590998008535 active site 590998008536 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 590998008537 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 590998008538 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 590998008539 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 590998008540 active site 590998008541 metal binding site [ion binding]; metal-binding site 590998008542 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 590998008543 active site 590998008544 metal binding site [ion binding]; metal-binding site 590998008545 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 590998008546 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 590998008547 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 590998008548 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 590998008549 FAD binding domain; Region: FAD_binding_3; pfam01494 590998008550 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 590998008551 Transcriptional regulator [Transcription]; Region: IclR; COG1414 590998008552 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 590998008553 Bacterial transcriptional regulator; Region: IclR; pfam01614 590998008554 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 590998008555 classical (c) SDRs; Region: SDR_c; cd05233 590998008556 NAD(P) binding site [chemical binding]; other site 590998008557 active site 590998008558 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 590998008559 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 590998008560 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 590998008561 nucleotide binding site [chemical binding]; other site 590998008562 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 590998008563 active site 590998008564 Zn2+ binding site [ion binding]; other site 590998008565 intersubunit interface [polypeptide binding]; other site 590998008566 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 590998008567 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 590998008568 Predicted transcriptional regulators [Transcription]; Region: COG1695 590998008569 Transcriptional regulator PadR-like family; Region: PadR; cl17335 590998008570 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 590998008571 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 590998008572 Protein of unknown function (DUF501); Region: DUF501; pfam04417 590998008573 Septum formation initiator; Region: DivIC; pfam04977 590998008574 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 590998008575 enolase; Provisional; Region: eno; PRK00077 590998008576 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 590998008577 dimer interface [polypeptide binding]; other site 590998008578 metal binding site [ion binding]; metal-binding site 590998008579 substrate binding pocket [chemical binding]; other site 590998008580 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 590998008581 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 590998008582 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 590998008583 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 590998008584 ligand binding site [chemical binding]; other site 590998008585 homodimer interface [polypeptide binding]; other site 590998008586 NAD(P) binding site [chemical binding]; other site 590998008587 trimer interface B [polypeptide binding]; other site 590998008588 trimer interface A [polypeptide binding]; other site 590998008589 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 590998008590 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 590998008591 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 590998008592 homodimer interface [polypeptide binding]; other site 590998008593 metal binding site [ion binding]; metal-binding site 590998008594 tetratricopeptide repeat protein; Provisional; Region: PRK11788 590998008595 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 590998008596 DEAD-like helicases superfamily; Region: DEXDc; smart00487 590998008597 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 590998008598 ATP binding site [chemical binding]; other site 590998008599 putative Mg++ binding site [ion binding]; other site 590998008600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 590998008601 nucleotide binding region [chemical binding]; other site 590998008602 ATP-binding site [chemical binding]; other site 590998008603 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 590998008604 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 590998008605 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 590998008606 active site 590998008607 nucleotide binding site [chemical binding]; other site 590998008608 HIGH motif; other site 590998008609 KMSKS motif; other site 590998008610 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 590998008611 Chain length determinant protein; Region: Wzz; cl15801 590998008612 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 590998008613 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 590998008614 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 590998008615 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 590998008616 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 590998008617 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 590998008618 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 590998008619 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 590998008620 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 590998008621 active site 590998008622 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 590998008623 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 590998008624 Interdomain contacts; other site 590998008625 Cytokine receptor motif; other site 590998008626 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 590998008627 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 590998008628 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 590998008629 PQQ-like domain; Region: PQQ_2; pfam13360 590998008630 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 590998008631 Interdomain contacts; other site 590998008632 Cytokine receptor motif; other site 590998008633 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 590998008634 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 590998008635 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 590998008636 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 590998008637 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 590998008638 Bacterial sugar transferase; Region: Bac_transf; pfam02397 590998008639 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 590998008640 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 590998008641 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 590998008642 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 590998008643 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 590998008644 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 590998008645 Right handed beta helix region; Region: Beta_helix; pfam13229 590998008646 Right handed beta helix region; Region: Beta_helix; pfam13229 590998008647 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 590998008648 putative active site [active] 590998008649 catalytic residue [active] 590998008650 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 590998008651 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 590998008652 5S rRNA interface [nucleotide binding]; other site 590998008653 CTC domain interface [polypeptide binding]; other site 590998008654 L16 interface [polypeptide binding]; other site 590998008655 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 590998008656 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 590998008657 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 590998008658 active site 590998008659 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 590998008660 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 590998008661 Substrate binding site; other site 590998008662 Mg++ binding site; other site 590998008663 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 590998008664 active site 590998008665 substrate binding site [chemical binding]; other site 590998008666 CoA binding site [chemical binding]; other site 590998008667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998008668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998008669 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 590998008670 MarR family; Region: MarR_2; cl17246 590998008671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998008672 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 590998008673 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 590998008674 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 590998008675 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 590998008676 catalytic residue [active] 590998008677 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 590998008678 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 590998008679 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 590998008680 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 590998008681 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 590998008682 IucA / IucC family; Region: IucA_IucC; pfam04183 590998008683 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 590998008684 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 590998008685 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 590998008686 active site 590998008687 Penicillin amidase; Region: Penicil_amidase; pfam01804 590998008688 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 590998008689 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 590998008690 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 590998008691 ABC transporter; Region: ABC_tran_2; pfam12848 590998008692 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 590998008693 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 590998008694 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 590998008695 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 590998008696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 590998008697 Domain of unknown function (DUF348); Region: DUF348; pfam03990 590998008698 G5 domain; Region: G5; pfam07501 590998008699 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 590998008700 N-acetyl-D-glucosamine binding site [chemical binding]; other site 590998008701 catalytic residue [active] 590998008702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 590998008703 Domain of unknown function (DUF348); Region: DUF348; pfam03990 590998008704 Domain of unknown function (DUF348); Region: DUF348; pfam03990 590998008705 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 590998008706 N-acetyl-D-glucosamine binding site [chemical binding]; other site 590998008707 catalytic residue [active] 590998008708 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 590998008709 active site 590998008710 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 590998008711 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 590998008712 active site 590998008713 HIGH motif; other site 590998008714 KMSKS motif; other site 590998008715 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 590998008716 tRNA binding surface [nucleotide binding]; other site 590998008717 anticodon binding site; other site 590998008718 Bacterial PH domain; Region: DUF304; pfam03703 590998008719 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 590998008720 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 590998008721 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 590998008722 catalytic triad [active] 590998008723 conserved cis-peptide bond; other site 590998008724 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 590998008725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998008726 Walker A/P-loop; other site 590998008727 ATP binding site [chemical binding]; other site 590998008728 Q-loop/lid; other site 590998008729 ABC transporter signature motif; other site 590998008730 Walker B; other site 590998008731 D-loop; other site 590998008732 H-loop/switch region; other site 590998008733 Predicted methyltransferases [General function prediction only]; Region: COG0313 590998008734 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 590998008735 putative SAM binding site [chemical binding]; other site 590998008736 putative homodimer interface [polypeptide binding]; other site 590998008737 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 590998008738 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 590998008739 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 590998008740 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 590998008741 active site 590998008742 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 590998008743 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 590998008744 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 590998008745 Winged helix-turn helix; Region: HTH_29; pfam13551 590998008746 Integrase core domain; Region: rve; pfam00665 590998008747 Integrase core domain; Region: rve_3; pfam13683 590998008748 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 590998008749 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 590998008750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 590998008751 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 590998008752 dimer interface [polypeptide binding]; other site 590998008753 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 590998008754 putative functional site; other site 590998008755 putative MPT binding site; other site 590998008756 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 590998008757 active site 590998008758 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 590998008759 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 590998008760 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 590998008761 active site 590998008762 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 590998008763 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 590998008764 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 590998008765 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 590998008766 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 590998008767 nitrate reductase, beta subunit; Region: narH; TIGR01660 590998008768 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 590998008769 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 590998008770 [4Fe-4S] binding site [ion binding]; other site 590998008771 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 590998008772 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 590998008773 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 590998008774 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 590998008775 molybdopterin cofactor binding site; other site 590998008776 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 590998008777 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 590998008778 NAD binding site [chemical binding]; other site 590998008779 catalytic Zn binding site [ion binding]; other site 590998008780 structural Zn binding site [ion binding]; other site 590998008781 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 590998008782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998008783 putative substrate translocation pore; other site 590998008784 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 590998008785 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 590998008786 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 590998008787 Methyltransferase domain; Region: Methyltransf_11; pfam08241 590998008788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998008789 Coenzyme A binding pocket [chemical binding]; other site 590998008790 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 590998008791 active site 590998008792 catalytic residues [active] 590998008793 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 590998008794 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 590998008795 putative sugar binding sites [chemical binding]; other site 590998008796 Q-X-W motif; other site 590998008797 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 590998008798 YCII-related domain; Region: YCII; cl00999 590998008799 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 590998008800 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 590998008801 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 590998008802 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 590998008803 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 590998008804 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 590998008805 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 590998008806 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 590998008807 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 590998008808 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 590998008809 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 590998008810 A new structural DNA glycosylase; Region: AlkD_like; cd06561 590998008811 active site 590998008812 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 590998008813 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 590998008814 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 590998008815 TrkA-N domain; Region: TrkA_N; pfam02254 590998008816 Fic family protein [Function unknown]; Region: COG3177 590998008817 Fic/DOC family; Region: Fic; pfam02661 590998008818 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 590998008819 ATP binding site [chemical binding]; other site 590998008820 putative Mg++ binding site [ion binding]; other site 590998008821 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 590998008822 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 590998008823 nucleotide binding region [chemical binding]; other site 590998008824 ATP-binding site [chemical binding]; other site 590998008825 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 590998008826 Fructosamine kinase; Region: Fructosamin_kin; cl17579 590998008827 Phosphotransferase enzyme family; Region: APH; pfam01636 590998008828 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 590998008829 homotrimer interaction site [polypeptide binding]; other site 590998008830 putative active site [active] 590998008831 Predicted transcriptional regulators [Transcription]; Region: COG1733 590998008832 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 590998008833 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 590998008834 active site 590998008835 TrwC relaxase; Region: TrwC; pfam08751 590998008836 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 590998008837 AAA domain; Region: AAA_30; pfam13604 590998008838 Family description; Region: UvrD_C_2; pfam13538 590998008839 Helix-turn-helix domain; Region: HTH_17; pfam12728 590998008840 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 590998008841 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 590998008842 active site 590998008843 DNA binding site [nucleotide binding] 590998008844 Int/Topo IB signature motif; other site 590998008845 hypothetical protein; Provisional; Region: PRK06153 590998008846 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 590998008847 ATP binding site [chemical binding]; other site 590998008848 substrate interface [chemical binding]; other site 590998008849 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 590998008850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 590998008851 non-specific DNA binding site [nucleotide binding]; other site 590998008852 salt bridge; other site 590998008853 sequence-specific DNA binding site [nucleotide binding]; other site 590998008854 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 590998008855 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 590998008856 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 590998008857 putative sugar binding sites [chemical binding]; other site 590998008858 Q-X-W motif; other site 590998008859 Glycosyl hydrolase family 62; Region: Glyco_hydro_62; pfam03664 590998008860 active site 590998008861 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 590998008862 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 590998008863 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 590998008864 putative sugar binding sites [chemical binding]; other site 590998008865 Q-X-W motif; other site 590998008866 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 590998008867 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 590998008868 putative sugar binding sites [chemical binding]; other site 590998008869 Q-X-W motif; other site 590998008870 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 590998008871 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 590998008872 active site 590998008873 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 590998008874 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 590998008875 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 590998008876 putative trimer interface [polypeptide binding]; other site 590998008877 putative CoA binding site [chemical binding]; other site 590998008878 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 590998008879 active site 590998008880 CBD_II domain; Region: CBD_II; smart00637 590998008881 Glyco_18 domain; Region: Glyco_18; smart00636 590998008882 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 590998008883 active site 590998008884 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 590998008885 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 590998008886 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 590998008887 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 590998008888 homodimer interface [polypeptide binding]; other site 590998008889 chemical substrate binding site [chemical binding]; other site 590998008890 oligomer interface [polypeptide binding]; other site 590998008891 metal binding site [ion binding]; metal-binding site 590998008892 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 590998008893 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 590998008894 substrate binding site [chemical binding]; other site 590998008895 ATP binding site [chemical binding]; other site 590998008896 Survival protein SurE; Region: SurE; pfam01975 590998008897 prenyltransferase; Reviewed; Region: ubiA; PRK13105 590998008898 UbiA prenyltransferase family; Region: UbiA; pfam01040 590998008899 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 590998008900 phytoene desaturase; Region: crtI_fam; TIGR02734 590998008901 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 590998008902 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 590998008903 substrate binding pocket [chemical binding]; other site 590998008904 substrate-Mg2+ binding site; other site 590998008905 aspartate-rich region 1; other site 590998008906 aspartate-rich region 2; other site 590998008907 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 590998008908 substrate binding pocket [chemical binding]; other site 590998008909 substrate-Mg2+ binding site; other site 590998008910 aspartate-rich region 1; other site 590998008911 aspartate-rich region 2; other site 590998008912 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 590998008913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998008914 NAD(P) binding site [chemical binding]; other site 590998008915 active site 590998008916 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 590998008917 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 590998008918 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 590998008919 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 590998008920 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 590998008921 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 590998008922 DNA binding residues [nucleotide binding] 590998008923 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 590998008924 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 590998008925 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 590998008926 dimerization interface [polypeptide binding]; other site 590998008927 putative ATP binding site [chemical binding]; other site 590998008928 amidophosphoribosyltransferase; Provisional; Region: PRK07847 590998008929 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 590998008930 active site 590998008931 tetramer interface [polypeptide binding]; other site 590998008932 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 590998008933 active site 590998008934 Cellulose binding domain; Region: CBM_2; pfam00553 590998008935 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 590998008936 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 590998008937 GTPase/Zn-binding domain interface [polypeptide binding]; other site 590998008938 GTP/Mg2+ binding site [chemical binding]; other site 590998008939 G4 box; other site 590998008940 G5 box; other site 590998008941 G1 box; other site 590998008942 Switch I region; other site 590998008943 G2 box; other site 590998008944 G3 box; other site 590998008945 Switch II region; other site 590998008946 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 590998008947 ATP-grasp domain; Region: ATP-grasp_4; cl17255 590998008948 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 590998008949 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 590998008950 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 590998008951 dimerization interface [polypeptide binding]; other site 590998008952 ATP binding site [chemical binding]; other site 590998008953 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 590998008954 dimerization interface [polypeptide binding]; other site 590998008955 ATP binding site [chemical binding]; other site 590998008956 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 590998008957 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 590998008958 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 590998008959 active site 590998008960 catalytic tetrad [active] 590998008961 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 590998008962 acyl-CoA oxidase; Region: PLN02312 590998008963 active site 590998008964 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998008965 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 590998008966 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 590998008967 dimer interface [polypeptide binding]; other site 590998008968 active site 590998008969 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 590998008970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998008971 NAD(P) binding site [chemical binding]; other site 590998008972 active site 590998008973 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 590998008974 active site 2 [active] 590998008975 active site 1 [active] 590998008976 Methyltransferase domain; Region: Methyltransf_11; pfam08241 590998008977 Fasciclin domain; Region: Fasciclin; cl02663 590998008978 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 590998008979 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 590998008980 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 590998008981 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 590998008982 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 590998008983 catalytic residue [active] 590998008984 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 590998008985 active site residue [active] 590998008986 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 590998008987 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 590998008988 homodimer interface [polypeptide binding]; other site 590998008989 substrate-cofactor binding pocket; other site 590998008990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998008991 catalytic residue [active] 590998008992 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 590998008993 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998008994 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 590998008995 Walker A/P-loop; other site 590998008996 ATP binding site [chemical binding]; other site 590998008997 Q-loop/lid; other site 590998008998 ABC transporter signature motif; other site 590998008999 Walker B; other site 590998009000 D-loop; other site 590998009001 H-loop/switch region; other site 590998009002 ABC-2 type transporter; Region: ABC2_membrane; cl17235 590998009003 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 590998009004 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 590998009005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998009006 NAD(P) binding site [chemical binding]; other site 590998009007 active site 590998009008 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 590998009009 active site 590998009010 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 590998009011 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 590998009012 active site 590998009013 TDP-binding site; other site 590998009014 acceptor substrate-binding pocket; other site 590998009015 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 590998009016 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 590998009017 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 590998009018 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 590998009019 active site 590998009020 Protein of unknown function DUF72; Region: DUF72; pfam01904 590998009021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998009022 Coenzyme A binding pocket [chemical binding]; other site 590998009023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998009024 Coenzyme A binding pocket [chemical binding]; other site 590998009025 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 590998009026 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 590998009027 putative active site [active] 590998009028 catalytic triad [active] 590998009029 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 590998009030 Predicted transcriptional regulators [Transcription]; Region: COG1695 590998009031 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 590998009032 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 590998009033 active site 590998009034 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 590998009035 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 590998009036 active site 590998009037 substrate binding site [chemical binding]; other site 590998009038 Mg2+ binding site [ion binding]; other site 590998009039 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 590998009040 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 590998009041 Walker A/P-loop; other site 590998009042 ATP binding site [chemical binding]; other site 590998009043 Q-loop/lid; other site 590998009044 ABC transporter signature motif; other site 590998009045 Walker B; other site 590998009046 D-loop; other site 590998009047 H-loop/switch region; other site 590998009048 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 590998009049 ABC-ATPase subunit interface; other site 590998009050 dimer interface [polypeptide binding]; other site 590998009051 putative PBP binding regions; other site 590998009052 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 590998009053 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 590998009054 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 590998009055 ABC-ATPase subunit interface; other site 590998009056 dimer interface [polypeptide binding]; other site 590998009057 putative PBP binding regions; other site 590998009058 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 590998009059 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 590998009060 siderophore binding site; other site 590998009061 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 590998009062 active site 590998009063 ATP binding site [chemical binding]; other site 590998009064 substrate binding site [chemical binding]; other site 590998009065 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 590998009066 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 590998009067 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 590998009068 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 590998009069 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998009070 dimerization interface [polypeptide binding]; other site 590998009071 putative DNA binding site [nucleotide binding]; other site 590998009072 putative Zn2+ binding site [ion binding]; other site 590998009073 H+ Antiporter protein; Region: 2A0121; TIGR00900 590998009074 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 590998009075 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 590998009076 GDP-binding site [chemical binding]; other site 590998009077 ACT binding site; other site 590998009078 IMP binding site; other site 590998009079 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 590998009080 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 590998009081 anti sigma factor interaction site; other site 590998009082 regulatory phosphorylation site [posttranslational modification]; other site 590998009083 PAS domain; Region: PAS_9; pfam13426 590998009084 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 590998009085 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 590998009086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 590998009087 ATP binding site [chemical binding]; other site 590998009088 Mg2+ binding site [ion binding]; other site 590998009089 G-X-G motif; other site 590998009090 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 590998009091 anti sigma factor interaction site; other site 590998009092 regulatory phosphorylation site [posttranslational modification]; other site 590998009093 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 590998009094 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 590998009095 active site 590998009096 intersubunit interface [polypeptide binding]; other site 590998009097 zinc binding site [ion binding]; other site 590998009098 Na+ binding site [ion binding]; other site 590998009099 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 590998009100 nucleophilic elbow; other site 590998009101 catalytic triad; other site 590998009102 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 590998009103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 590998009104 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 590998009105 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 590998009106 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998009107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998009108 putative PBP binding loops; other site 590998009109 dimer interface [polypeptide binding]; other site 590998009110 ABC-ATPase subunit interface; other site 590998009111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998009112 ABC-ATPase subunit interface; other site 590998009113 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998009114 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998009115 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998009116 DNA binding residues [nucleotide binding] 590998009117 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998009118 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998009119 DNA binding site [nucleotide binding] 590998009120 domain linker motif; other site 590998009121 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998009122 dimerization interface [polypeptide binding]; other site 590998009123 ligand binding site [chemical binding]; other site 590998009124 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 590998009125 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 590998009126 UMP phosphatase; Provisional; Region: PRK10444 590998009127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 590998009128 active site 590998009129 motif I; other site 590998009130 motif II; other site 590998009131 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 590998009132 YwiC-like protein; Region: YwiC; pfam14256 590998009133 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 590998009134 active site 590998009135 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 590998009136 classical (c) SDRs; Region: SDR_c; cd05233 590998009137 NAD(P) binding site [chemical binding]; other site 590998009138 active site 590998009139 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 590998009140 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 590998009141 ATP binding site [chemical binding]; other site 590998009142 putative Mg++ binding site [ion binding]; other site 590998009143 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 590998009144 nucleotide binding region [chemical binding]; other site 590998009145 ATP-binding site [chemical binding]; other site 590998009146 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 590998009147 HRDC domain; Region: HRDC; pfam00570 590998009148 TM2 domain; Region: TM2; pfam05154 590998009149 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 590998009150 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998009151 DNA binding site [nucleotide binding] 590998009152 domain linker motif; other site 590998009153 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998009154 dimerization interface [polypeptide binding]; other site 590998009155 ligand binding site [chemical binding]; other site 590998009156 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 590998009157 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 590998009158 putative active site pocket [active] 590998009159 putative metal binding site [ion binding]; other site 590998009160 Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488 590998009161 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 590998009162 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 590998009163 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 590998009164 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 590998009165 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 590998009166 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 590998009167 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998009168 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998009169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998009170 dimer interface [polypeptide binding]; other site 590998009171 conserved gate region; other site 590998009172 putative PBP binding loops; other site 590998009173 ABC-ATPase subunit interface; other site 590998009174 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 590998009175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998009176 dimer interface [polypeptide binding]; other site 590998009177 conserved gate region; other site 590998009178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 590998009179 ABC-ATPase subunit interface; other site 590998009180 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 590998009181 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 590998009182 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 590998009183 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998009184 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998009185 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 590998009186 putative dimerization interface [polypeptide binding]; other site 590998009187 putative ligand binding site [chemical binding]; other site 590998009188 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 590998009189 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 590998009190 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 590998009191 catalytic site [active] 590998009192 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 590998009193 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 590998009194 active site 590998009195 catalytic tetrad [active] 590998009196 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 590998009197 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 590998009198 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 590998009199 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 590998009200 metal binding site [ion binding]; metal-binding site 590998009201 active site 590998009202 I-site; other site 590998009203 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 590998009204 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 590998009205 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 590998009206 putative hydrophobic ligand binding site [chemical binding]; other site 590998009207 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 590998009208 Amidohydrolase; Region: Amidohydro_2; pfam04909 590998009209 active site 590998009210 Transcriptional regulators [Transcription]; Region: FadR; COG2186 590998009211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 590998009212 DNA-binding site [nucleotide binding]; DNA binding site 590998009213 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 590998009214 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998009215 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998009216 DNA binding site [nucleotide binding] 590998009217 domain linker motif; other site 590998009218 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998009219 ligand binding site [chemical binding]; other site 590998009220 dimerization interface [polypeptide binding]; other site 590998009221 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 590998009222 galactarate dehydratase; Region: galactar-dH20; TIGR03248 590998009223 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 590998009224 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 590998009225 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 590998009226 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 590998009227 substrate binding site [chemical binding]; other site 590998009228 ATP binding site [chemical binding]; other site 590998009229 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 590998009230 active site 590998009231 intersubunit interface [polypeptide binding]; other site 590998009232 catalytic residue [active] 590998009233 glucuronate isomerase; Reviewed; Region: PRK02925 590998009234 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 590998009235 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998009236 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998009237 DNA binding site [nucleotide binding] 590998009238 domain linker motif; other site 590998009239 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998009240 ligand binding site [chemical binding]; other site 590998009241 dimerization interface [polypeptide binding]; other site 590998009242 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 590998009243 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 590998009244 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 590998009245 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 590998009246 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 590998009247 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 590998009248 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998009249 dimerization interface [polypeptide binding]; other site 590998009250 putative DNA binding site [nucleotide binding]; other site 590998009251 putative Zn2+ binding site [ion binding]; other site 590998009252 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 590998009253 hydrophobic ligand binding site; other site 590998009254 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 590998009255 active site 590998009256 oxyanion hole [active] 590998009257 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 590998009258 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 590998009259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998009260 NAD(P) binding site [chemical binding]; other site 590998009261 active site 590998009262 Membrane transport protein; Region: Mem_trans; cl09117 590998009263 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 590998009264 N- and C-terminal domain interface [polypeptide binding]; other site 590998009265 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 590998009266 active site 590998009267 putative catalytic site [active] 590998009268 metal binding site [ion binding]; metal-binding site 590998009269 ATP binding site [chemical binding]; other site 590998009270 carbohydrate binding site [chemical binding]; other site 590998009271 short chain dehydrogenase; Validated; Region: PRK08324 590998009272 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 590998009273 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 590998009274 putative NAD(P) binding site [chemical binding]; other site 590998009275 active site 590998009276 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 590998009277 Domain of unknown function (DUF718); Region: DUF718; pfam05336 590998009278 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998009279 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998009280 DNA binding site [nucleotide binding] 590998009281 domain linker motif; other site 590998009282 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998009283 dimerization interface [polypeptide binding]; other site 590998009284 ligand binding site [chemical binding]; other site 590998009285 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 590998009286 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 590998009287 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 590998009288 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 590998009289 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 590998009290 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 590998009291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998009292 Coenzyme A binding pocket [chemical binding]; other site 590998009293 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 590998009294 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 590998009295 active site 590998009296 DNA binding site [nucleotide binding] 590998009297 catalytic site [active] 590998009298 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 590998009299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 590998009300 non-specific DNA binding site [nucleotide binding]; other site 590998009301 salt bridge; other site 590998009302 sequence-specific DNA binding site [nucleotide binding]; other site 590998009303 Cupin domain; Region: Cupin_2; pfam07883 590998009304 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 590998009305 Methyltransferase domain; Region: Methyltransf_23; pfam13489 590998009306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998009307 S-adenosylmethionine binding site [chemical binding]; other site 590998009308 Cupin domain; Region: Cupin_2; pfam07883 590998009309 Methane oxygenase PmoA; Region: PmoA; pfam14100 590998009310 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 590998009311 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 590998009312 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 590998009313 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 590998009314 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 590998009315 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998009316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998009317 dimer interface [polypeptide binding]; other site 590998009318 conserved gate region; other site 590998009319 putative PBP binding loops; other site 590998009320 ABC-ATPase subunit interface; other site 590998009321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998009322 dimer interface [polypeptide binding]; other site 590998009323 conserved gate region; other site 590998009324 putative PBP binding loops; other site 590998009325 ABC-ATPase subunit interface; other site 590998009326 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998009327 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 590998009328 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 590998009329 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 590998009330 active site 590998009331 substrate binding site [chemical binding]; other site 590998009332 FMN binding site [chemical binding]; other site 590998009333 putative catalytic residues [active] 590998009334 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 590998009335 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 590998009336 putative NAD(P) binding site [chemical binding]; other site 590998009337 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 590998009338 substrate binding pocket [chemical binding]; other site 590998009339 catalytic residues [active] 590998009340 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 590998009341 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 590998009342 putative sugar binding sites [chemical binding]; other site 590998009343 Q-X-W motif; other site 590998009344 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 590998009345 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998009346 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998009347 DNA binding site [nucleotide binding] 590998009348 domain linker motif; other site 590998009349 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998009350 dimerization interface [polypeptide binding]; other site 590998009351 ligand binding site [chemical binding]; other site 590998009352 Methane oxygenase PmoA; Region: PmoA; pfam14100 590998009353 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998009354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998009355 dimer interface [polypeptide binding]; other site 590998009356 putative PBP binding loops; other site 590998009357 ABC-ATPase subunit interface; other site 590998009358 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998009359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998009360 dimer interface [polypeptide binding]; other site 590998009361 conserved gate region; other site 590998009362 putative PBP binding loops; other site 590998009363 ABC-ATPase subunit interface; other site 590998009364 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998009365 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 590998009366 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 590998009367 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 590998009368 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 590998009369 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 590998009370 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 590998009371 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 590998009372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998009373 putative PBP binding loops; other site 590998009374 ABC-ATPase subunit interface; other site 590998009375 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 590998009376 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 590998009377 Walker A/P-loop; other site 590998009378 ATP binding site [chemical binding]; other site 590998009379 Q-loop/lid; other site 590998009380 ABC transporter signature motif; other site 590998009381 Walker B; other site 590998009382 D-loop; other site 590998009383 H-loop/switch region; other site 590998009384 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 590998009385 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 590998009386 active site 590998009387 non-prolyl cis peptide bond; other site 590998009388 MSEP-CTERM protein; Region: MSEP-CTERM; TIGR04286 590998009389 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 590998009390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998009391 NAD(P) binding site [chemical binding]; other site 590998009392 active site 590998009393 Transcriptional regulator [Transcription]; Region: IclR; COG1414 590998009394 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 590998009395 Bacterial transcriptional regulator; Region: IclR; pfam01614 590998009396 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 590998009397 DctM-like transporters; Region: DctM; pfam06808 590998009398 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 590998009399 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 590998009400 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 590998009401 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 590998009402 Clp protease ATP binding subunit; Region: clpC; CHL00095 590998009403 Clp amino terminal domain; Region: Clp_N; pfam02861 590998009404 Clp amino terminal domain; Region: Clp_N; pfam02861 590998009405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 590998009406 Walker A motif; other site 590998009407 ATP binding site [chemical binding]; other site 590998009408 Walker B motif; other site 590998009409 arginine finger; other site 590998009410 UvrB/uvrC motif; Region: UVR; pfam02151 590998009411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 590998009412 Walker A motif; other site 590998009413 ATP binding site [chemical binding]; other site 590998009414 Walker B motif; other site 590998009415 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 590998009416 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 590998009417 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 590998009418 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 590998009419 active site 590998009420 catalytic site [active] 590998009421 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 590998009422 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 590998009423 Fatty acid desaturase; Region: FA_desaturase; pfam00487 590998009424 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 590998009425 putative di-iron ligands [ion binding]; other site 590998009426 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 590998009427 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 590998009428 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 590998009429 active site 590998009430 putative catalytic site [active] 590998009431 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 590998009432 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998009433 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 590998009434 DNA binding residues [nucleotide binding] 590998009435 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 590998009436 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 590998009437 MMPL family; Region: MMPL; pfam03176 590998009438 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 590998009439 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 590998009440 active site 590998009441 catalytic tetrad [active] 590998009442 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 590998009443 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 590998009444 heme-binding site [chemical binding]; other site 590998009445 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 590998009446 FAD binding pocket [chemical binding]; other site 590998009447 FAD binding motif [chemical binding]; other site 590998009448 phosphate binding motif [ion binding]; other site 590998009449 beta-alpha-beta structure motif; other site 590998009450 NAD binding pocket [chemical binding]; other site 590998009451 Heme binding pocket [chemical binding]; other site 590998009452 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 590998009453 putative ADP-ribose binding site [chemical binding]; other site 590998009454 putative active site [active] 590998009455 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 590998009456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998009457 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 590998009458 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 590998009459 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 590998009460 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 590998009461 putative active site [active] 590998009462 dimerization interface [polypeptide binding]; other site 590998009463 putative tRNAtyr binding site [nucleotide binding]; other site 590998009464 L-asparaginase II; Region: Asparaginase_II; pfam06089 590998009465 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 590998009466 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 590998009467 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 590998009468 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 590998009469 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 590998009470 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 590998009471 heme-binding site [chemical binding]; other site 590998009472 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 590998009473 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 590998009474 catalytic residues [active] 590998009475 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 590998009476 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 590998009477 DNA binding site [nucleotide binding] 590998009478 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 590998009479 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 590998009480 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 590998009481 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 590998009482 minor groove reading motif; other site 590998009483 helix-hairpin-helix signature motif; other site 590998009484 substrate binding pocket [chemical binding]; other site 590998009485 active site 590998009486 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 590998009487 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 590998009488 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 590998009489 ligand binding site [chemical binding]; other site 590998009490 flexible hinge region; other site 590998009491 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 590998009492 putative switch regulator; other site 590998009493 non-specific DNA interactions [nucleotide binding]; other site 590998009494 DNA binding site [nucleotide binding] 590998009495 sequence specific DNA binding site [nucleotide binding]; other site 590998009496 putative cAMP binding site [chemical binding]; other site 590998009497 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 590998009498 homotrimer interaction site [polypeptide binding]; other site 590998009499 putative active site [active] 590998009500 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 590998009501 Transcription factor WhiB; Region: Whib; pfam02467 590998009502 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 590998009503 Transglycosylase; Region: Transgly; pfam00912 590998009504 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 590998009505 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 590998009506 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 590998009507 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 590998009508 putative active site [active] 590998009509 putative metal binding site [ion binding]; other site 590998009510 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 590998009511 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 590998009512 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998009513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998009514 active site 590998009515 phosphorylation site [posttranslational modification] 590998009516 intermolecular recognition site; other site 590998009517 dimerization interface [polypeptide binding]; other site 590998009518 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998009519 DNA binding residues [nucleotide binding] 590998009520 Putative sensor; Region: Sensor; pfam13796 590998009521 Histidine kinase; Region: HisKA_3; pfam07730 590998009522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998009523 ATP binding site [chemical binding]; other site 590998009524 Mg2+ binding site [ion binding]; other site 590998009525 G-X-G motif; other site 590998009526 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 590998009527 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 590998009528 Interdomain contacts; other site 590998009529 Cytokine receptor motif; other site 590998009530 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 590998009531 Interdomain contacts; other site 590998009532 Cellulose binding domain; Region: CBM_2; pfam00553 590998009533 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 590998009534 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 590998009535 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 590998009536 Walker A/P-loop; other site 590998009537 ATP binding site [chemical binding]; other site 590998009538 Q-loop/lid; other site 590998009539 ABC transporter signature motif; other site 590998009540 Walker B; other site 590998009541 D-loop; other site 590998009542 H-loop/switch region; other site 590998009543 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 590998009544 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 590998009545 Walker A/P-loop; other site 590998009546 ATP binding site [chemical binding]; other site 590998009547 Q-loop/lid; other site 590998009548 ABC transporter signature motif; other site 590998009549 Walker B; other site 590998009550 D-loop; other site 590998009551 H-loop/switch region; other site 590998009552 Predicted transcriptional regulators [Transcription]; Region: COG1725 590998009553 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 590998009554 DNA-binding site [nucleotide binding]; DNA binding site 590998009555 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 590998009556 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 590998009557 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 590998009558 FAD binding domain; Region: FAD_binding_4; pfam01565 590998009559 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 590998009560 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 590998009561 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 590998009562 non-specific DNA binding site [nucleotide binding]; other site 590998009563 salt bridge; other site 590998009564 sequence-specific DNA binding site [nucleotide binding]; other site 590998009565 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 590998009566 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 590998009567 aspartate kinase; Reviewed; Region: PRK06635 590998009568 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 590998009569 putative nucleotide binding site [chemical binding]; other site 590998009570 putative catalytic residues [active] 590998009571 putative Mg ion binding site [ion binding]; other site 590998009572 putative aspartate binding site [chemical binding]; other site 590998009573 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 590998009574 putative allosteric regulatory site; other site 590998009575 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 590998009576 putative allosteric regulatory residue; other site 590998009577 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 590998009578 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 590998009579 Walker A/P-loop; other site 590998009580 ATP binding site [chemical binding]; other site 590998009581 Q-loop/lid; other site 590998009582 ABC transporter signature motif; other site 590998009583 Walker B; other site 590998009584 D-loop; other site 590998009585 H-loop/switch region; other site 590998009586 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 590998009587 recombination protein RecR; Reviewed; Region: recR; PRK00076 590998009588 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 590998009589 RecR protein; Region: RecR; pfam02132 590998009590 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 590998009591 putative active site [active] 590998009592 putative metal-binding site [ion binding]; other site 590998009593 tetramer interface [polypeptide binding]; other site 590998009594 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 590998009595 putative dimer interface [polypeptide binding]; other site 590998009596 ligand binding site [chemical binding]; other site 590998009597 Zn binding site [ion binding]; other site 590998009598 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 590998009599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 590998009600 Walker A motif; other site 590998009601 ATP binding site [chemical binding]; other site 590998009602 Walker B motif; other site 590998009603 arginine finger; other site 590998009604 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 590998009605 AsnC family; Region: AsnC_trans_reg; pfam01037 590998009606 Predicted ATPase [General function prediction only]; Region: COG3910 590998009607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 590998009608 Walker A/P-loop; other site 590998009609 ATP binding site [chemical binding]; other site 590998009610 Q-loop/lid; other site 590998009611 ABC transporter signature motif; other site 590998009612 Walker B; other site 590998009613 D-loop; other site 590998009614 H-loop/switch region; other site 590998009615 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 590998009616 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 590998009617 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 590998009618 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 590998009619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998009620 Coenzyme A binding pocket [chemical binding]; other site 590998009621 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 590998009622 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 590998009623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 590998009624 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 590998009625 PLD-like domain; Region: PLDc_2; pfam13091 590998009626 putative active site [active] 590998009627 catalytic site [active] 590998009628 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 590998009629 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 590998009630 ATP binding site [chemical binding]; other site 590998009631 putative Mg++ binding site [ion binding]; other site 590998009632 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 590998009633 nucleotide binding region [chemical binding]; other site 590998009634 ATP-binding site [chemical binding]; other site 590998009635 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 590998009636 Nuclease-related domain; Region: NERD; pfam08378 590998009637 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 590998009638 conserved cys residue [active] 590998009639 Short C-terminal domain; Region: SHOCT; pfam09851 590998009640 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 590998009641 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 590998009642 Fatty acid desaturase; Region: FA_desaturase; pfam00487 590998009643 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 590998009644 putative di-iron ligands [ion binding]; other site 590998009645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998009646 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 590998009647 active site 590998009648 phosphorylation site [posttranslational modification] 590998009649 intermolecular recognition site; other site 590998009650 dimerization interface [polypeptide binding]; other site 590998009651 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 590998009652 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 590998009653 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 590998009654 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 590998009655 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 590998009656 ligand binding site [chemical binding]; other site 590998009657 flexible hinge region; other site 590998009658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998009659 ATP binding site [chemical binding]; other site 590998009660 Mg2+ binding site [ion binding]; other site 590998009661 G-X-G motif; other site 590998009662 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 590998009663 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 590998009664 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 590998009665 metal binding site [ion binding]; metal-binding site 590998009666 active site 590998009667 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 590998009668 DNA-binding site [nucleotide binding]; DNA binding site 590998009669 RNA-binding motif; other site 590998009670 Fatty acid desaturase; Region: FA_desaturase; pfam00487 590998009671 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 590998009672 putative di-iron ligands [ion binding]; other site 590998009673 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 590998009674 DNA-binding site [nucleotide binding]; DNA binding site 590998009675 RNA-binding motif; other site 590998009676 hypothetical protein; Provisional; Region: PRK01842 590998009677 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 590998009678 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 590998009679 Tetratricopeptide repeat; Region: TPR_12; pfam13424 590998009680 binding surface 590998009681 TPR motif; other site 590998009682 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 590998009683 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 590998009684 Walker A/P-loop; other site 590998009685 ATP binding site [chemical binding]; other site 590998009686 Q-loop/lid; other site 590998009687 ABC transporter signature motif; other site 590998009688 Walker B; other site 590998009689 D-loop; other site 590998009690 H-loop/switch region; other site 590998009691 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 590998009692 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 590998009693 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 590998009694 HlyD family secretion protein; Region: HlyD_3; pfam13437 590998009695 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 590998009696 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 590998009697 DXD motif; other site 590998009698 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 590998009699 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 590998009700 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 590998009701 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 590998009702 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 590998009703 putative DNA binding site [nucleotide binding]; other site 590998009704 catalytic residue [active] 590998009705 putative H2TH interface [polypeptide binding]; other site 590998009706 putative catalytic residues [active] 590998009707 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 590998009708 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 590998009709 ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]; Region: RPT1; COG1222 590998009710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 590998009711 Peptidase family M41; Region: Peptidase_M41; pfam01434 590998009712 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 590998009713 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 590998009714 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 590998009715 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 590998009716 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 590998009717 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 590998009718 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 590998009719 active site 590998009720 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 590998009721 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 590998009722 active site 590998009723 Cupin domain; Region: Cupin_2; cl17218 590998009724 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 590998009725 RibD C-terminal domain; Region: RibD_C; cl17279 590998009726 EcsC protein family; Region: EcsC; pfam12787 590998009727 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 590998009728 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 590998009729 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 590998009730 MFS/sugar transport protein; Region: MFS_2; pfam13347 590998009731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998009732 putative substrate translocation pore; other site 590998009733 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998009734 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998009735 DNA binding site [nucleotide binding] 590998009736 domain linker motif; other site 590998009737 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998009738 ligand binding site [chemical binding]; other site 590998009739 dimerization interface [polypeptide binding]; other site 590998009740 Transposase; Region: HTH_Tnp_1; cl17663 590998009741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 590998009742 putative transposase OrfB; Reviewed; Region: PHA02517 590998009743 HTH-like domain; Region: HTH_21; pfam13276 590998009744 Integrase core domain; Region: rve; pfam00665 590998009745 Integrase core domain; Region: rve_3; cl15866 590998009746 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 590998009747 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 590998009748 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 590998009749 NAD-dependent deacetylase; Provisional; Region: PRK05333 590998009750 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 590998009751 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 590998009752 nucleoside/Zn binding site; other site 590998009753 dimer interface [polypeptide binding]; other site 590998009754 catalytic motif [active] 590998009755 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 590998009756 active site 590998009757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998009758 NADH(P)-binding; Region: NAD_binding_10; pfam13460 590998009759 NAD(P) binding site [chemical binding]; other site 590998009760 active site 590998009761 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 590998009762 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 590998009763 DNA binding residues [nucleotide binding] 590998009764 Putative zinc-finger; Region: zf-HC2; pfam13490 590998009765 Phosphotransferase enzyme family; Region: APH; pfam01636 590998009766 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 590998009767 active site 590998009768 ATP binding site [chemical binding]; other site 590998009769 substrate binding site [chemical binding]; other site 590998009770 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 590998009771 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 590998009772 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 590998009773 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 590998009774 putative ligand binding site [chemical binding]; other site 590998009775 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 590998009776 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 590998009777 Walker A/P-loop; other site 590998009778 ATP binding site [chemical binding]; other site 590998009779 Q-loop/lid; other site 590998009780 ABC transporter signature motif; other site 590998009781 Walker B; other site 590998009782 D-loop; other site 590998009783 H-loop/switch region; other site 590998009784 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 590998009785 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 590998009786 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 590998009787 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 590998009788 TM-ABC transporter signature motif; other site 590998009789 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998009790 putative DNA binding site [nucleotide binding]; other site 590998009791 putative Zn2+ binding site [ion binding]; other site 590998009792 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 590998009793 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 590998009794 nucleotide binding site [chemical binding]; other site 590998009795 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 590998009796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998009797 Walker A/P-loop; other site 590998009798 ATP binding site [chemical binding]; other site 590998009799 Q-loop/lid; other site 590998009800 ABC transporter signature motif; other site 590998009801 Walker B; other site 590998009802 D-loop; other site 590998009803 H-loop/switch region; other site 590998009804 legume lectins; Region: lectin_L-type; cl14058 590998009805 homotetramer interaction site [polypeptide binding]; other site 590998009806 carbohydrate binding site [chemical binding]; other site 590998009807 metal binding site [ion binding]; metal-binding site 590998009808 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 590998009809 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 590998009810 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 590998009811 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 590998009812 ATP cone domain; Region: ATP-cone; pfam03477 590998009813 Class III ribonucleotide reductase; Region: RNR_III; cd01675 590998009814 effector binding site; other site 590998009815 active site 590998009816 Zn binding site [ion binding]; other site 590998009817 glycine loop; other site 590998009818 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 590998009819 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 590998009820 dimer interface [polypeptide binding]; other site 590998009821 putative radical transfer pathway; other site 590998009822 diiron center [ion binding]; other site 590998009823 tyrosyl radical; other site 590998009824 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 590998009825 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 590998009826 Class I ribonucleotide reductase; Region: RNR_I; cd01679 590998009827 active site 590998009828 dimer interface [polypeptide binding]; other site 590998009829 catalytic residues [active] 590998009830 effector binding site; other site 590998009831 R2 peptide binding site; other site 590998009832 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 590998009833 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 590998009834 catalytic residues [active] 590998009835 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 590998009836 active site 590998009837 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 590998009838 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 590998009839 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 590998009840 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 590998009841 Walker A/P-loop; other site 590998009842 ATP binding site [chemical binding]; other site 590998009843 Q-loop/lid; other site 590998009844 ABC transporter signature motif; other site 590998009845 Walker B; other site 590998009846 D-loop; other site 590998009847 H-loop/switch region; other site 590998009848 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 590998009849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998009850 DNA repair protein RadA; Provisional; Region: PRK11823 590998009851 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 590998009852 Walker A motif; other site 590998009853 ATP binding site [chemical binding]; other site 590998009854 Walker B motif; other site 590998009855 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 590998009856 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 590998009857 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 590998009858 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 590998009859 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 590998009860 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 590998009861 minor groove reading motif; other site 590998009862 helix-hairpin-helix signature motif; other site 590998009863 active site 590998009864 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 590998009865 Cupin domain; Region: Cupin_2; cl17218 590998009866 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 590998009867 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 590998009868 Coenzyme A binding pocket [chemical binding]; other site 590998009869 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998009870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998009871 active site 590998009872 phosphorylation site [posttranslational modification] 590998009873 intermolecular recognition site; other site 590998009874 dimerization interface [polypeptide binding]; other site 590998009875 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998009876 DNA binding residues [nucleotide binding] 590998009877 dimerization interface [polypeptide binding]; other site 590998009878 Histidine kinase; Region: HisKA_3; pfam07730 590998009879 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 590998009880 ATP binding site [chemical binding]; other site 590998009881 Mg2+ binding site [ion binding]; other site 590998009882 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 590998009883 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 590998009884 DNA binding residues [nucleotide binding] 590998009885 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 590998009886 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 590998009887 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 590998009888 amphipathic channel; other site 590998009889 Asn-Pro-Ala signature motifs; other site 590998009890 glycerol kinase; Provisional; Region: glpK; PRK00047 590998009891 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 590998009892 N- and C-terminal domain interface [polypeptide binding]; other site 590998009893 active site 590998009894 MgATP binding site [chemical binding]; other site 590998009895 catalytic site [active] 590998009896 metal binding site [ion binding]; metal-binding site 590998009897 putative homotetramer interface [polypeptide binding]; other site 590998009898 glycerol binding site [chemical binding]; other site 590998009899 homodimer interface [polypeptide binding]; other site 590998009900 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 590998009901 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 590998009902 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 590998009903 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 590998009904 iron binding site [ion binding]; other site 590998009905 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 590998009906 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 590998009907 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 590998009908 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 590998009909 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 590998009910 classical (c) SDRs; Region: SDR_c; cd05233 590998009911 NAD(P) binding site [chemical binding]; other site 590998009912 active site 590998009913 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 590998009914 putative catalytic site [active] 590998009915 putative phosphate binding site [ion binding]; other site 590998009916 active site 590998009917 metal binding site A [ion binding]; metal-binding site 590998009918 DNA binding site [nucleotide binding] 590998009919 putative AP binding site [nucleotide binding]; other site 590998009920 putative metal binding site B [ion binding]; other site 590998009921 Septum formation; Region: Septum_form; pfam13845 590998009922 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 590998009923 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 590998009924 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 590998009925 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 590998009926 Septum formation; Region: Septum_form; pfam13845 590998009927 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 590998009928 Fe-S cluster binding site [ion binding]; other site 590998009929 active site 590998009930 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 590998009931 Clp amino terminal domain; Region: Clp_N; pfam02861 590998009932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 590998009933 Walker A motif; other site 590998009934 ATP binding site [chemical binding]; other site 590998009935 Walker B motif; other site 590998009936 arginine finger; other site 590998009937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 590998009938 Walker A motif; other site 590998009939 ATP binding site [chemical binding]; other site 590998009940 Walker B motif; other site 590998009941 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 590998009942 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 590998009943 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 590998009944 DNA binding residues [nucleotide binding] 590998009945 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 590998009946 catalytic core [active] 590998009947 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 590998009948 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 590998009949 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 590998009950 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 590998009951 Cl- selectivity filter; other site 590998009952 Cl- binding residues [ion binding]; other site 590998009953 pore gating glutamate residue; other site 590998009954 dimer interface [polypeptide binding]; other site 590998009955 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 590998009956 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 590998009957 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 590998009958 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 590998009959 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 590998009960 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 590998009961 dimerization interface [polypeptide binding]; other site 590998009962 Transcriptional regulator [Transcription]; Region: LysR; COG0583 590998009963 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 590998009964 homodimer interface [polypeptide binding]; other site 590998009965 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 590998009966 active site pocket [active] 590998009967 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 590998009968 FtsX-like permease family; Region: FtsX; pfam02687 590998009969 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 590998009970 FtsX-like permease family; Region: FtsX; pfam02687 590998009971 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 590998009972 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 590998009973 Walker A/P-loop; other site 590998009974 ATP binding site [chemical binding]; other site 590998009975 Q-loop/lid; other site 590998009976 ABC transporter signature motif; other site 590998009977 Walker B; other site 590998009978 D-loop; other site 590998009979 H-loop/switch region; other site 590998009980 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 590998009981 putative active site [active] 590998009982 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 590998009983 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; pfam07972 590998009984 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 590998009985 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998009986 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 590998009987 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 590998009988 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 590998009989 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 590998009990 Domain of unknown function DUF21; Region: DUF21; pfam01595 590998009991 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 590998009992 Domain of unknown function DUF21; Region: DUF21; pfam01595 590998009993 FOG: CBS domain [General function prediction only]; Region: COG0517 590998009994 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 590998009995 Transporter associated domain; Region: CorC_HlyC; pfam03471 590998009996 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 590998009997 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 590998009998 dimer interface [polypeptide binding]; other site 590998009999 HTH domain; Region: HTH_11; pfam08279 590998010000 WYL domain; Region: WYL; pfam13280 590998010001 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 590998010002 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 590998010003 active site 590998010004 ADP/pyrophosphate binding site [chemical binding]; other site 590998010005 dimerization interface [polypeptide binding]; other site 590998010006 allosteric effector site; other site 590998010007 fructose-1,6-bisphosphate binding site; other site 590998010008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 590998010009 NAD(P) binding site [chemical binding]; other site 590998010010 active site 590998010011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998010012 S-adenosylmethionine binding site [chemical binding]; other site 590998010013 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 590998010014 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 590998010015 Uncharacterized conserved protein [Function unknown]; Region: COG2966 590998010016 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 590998010017 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 590998010018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 590998010019 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 590998010020 RNB domain; Region: RNB; pfam00773 590998010021 Predicted membrane protein [Function unknown]; Region: COG1971 590998010022 Domain of unknown function DUF; Region: DUF204; pfam02659 590998010023 Domain of unknown function DUF; Region: DUF204; pfam02659 590998010024 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 590998010025 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 590998010026 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 590998010027 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 590998010028 MarR family; Region: MarR; pfam01047 590998010029 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 590998010030 putative hydrophobic ligand binding site [chemical binding]; other site 590998010031 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998010032 dimerization interface [polypeptide binding]; other site 590998010033 putative DNA binding site [nucleotide binding]; other site 590998010034 putative Zn2+ binding site [ion binding]; other site 590998010035 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 590998010036 GAF domain; Region: GAF; pfam01590 590998010037 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 590998010038 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 590998010039 active site 590998010040 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 590998010041 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 590998010042 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 590998010043 anti sigma factor interaction site; other site 590998010044 regulatory phosphorylation site [posttranslational modification]; other site 590998010045 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 590998010046 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 590998010047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 590998010048 Cache domain; Region: Cache_2; pfam08269 590998010049 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 590998010050 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 590998010051 dimer interface [polypeptide binding]; other site 590998010052 putative CheW interface [polypeptide binding]; other site 590998010053 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 590998010054 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 590998010055 G1 box; other site 590998010056 GTP/Mg2+ binding site [chemical binding]; other site 590998010057 G2 box; other site 590998010058 Switch I region; other site 590998010059 G3 box; other site 590998010060 Switch II region; other site 590998010061 G4 box; other site 590998010062 G5 box; other site 590998010063 Protein of unknown function (DUF742); Region: DUF742; pfam05331 590998010064 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 590998010065 Nitrate and nitrite sensing; Region: NIT; pfam08376 590998010066 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 590998010067 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 590998010068 dimerization interface [polypeptide binding]; other site 590998010069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998010070 ATP binding site [chemical binding]; other site 590998010071 Mg2+ binding site [ion binding]; other site 590998010072 G-X-G motif; other site 590998010073 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 590998010074 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 590998010075 NAD(P) binding site [chemical binding]; other site 590998010076 dimerization interface [polypeptide binding]; other site 590998010077 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 590998010078 putative active cleft [active] 590998010079 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 590998010080 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 590998010081 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998010082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998010083 dimer interface [polypeptide binding]; other site 590998010084 conserved gate region; other site 590998010085 putative PBP binding loops; other site 590998010086 ABC-ATPase subunit interface; other site 590998010087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998010088 dimer interface [polypeptide binding]; other site 590998010089 conserved gate region; other site 590998010090 putative PBP binding loops; other site 590998010091 ABC-ATPase subunit interface; other site 590998010092 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 590998010093 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 590998010094 active site 590998010095 motif I; other site 590998010096 motif II; other site 590998010097 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 590998010098 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 590998010099 seryl-tRNA synthetase; Provisional; Region: PRK05431 590998010100 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 590998010101 dimer interface [polypeptide binding]; other site 590998010102 active site 590998010103 motif 1; other site 590998010104 motif 2; other site 590998010105 motif 3; other site 590998010106 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 590998010107 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 590998010108 Cna protein B-type domain; Region: Cna_B; pfam05738 590998010109 prephenate dehydratase; Provisional; Region: PRK11898 590998010110 Prephenate dehydratase; Region: PDT; pfam00800 590998010111 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 590998010112 putative L-Phe binding site [chemical binding]; other site 590998010113 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 590998010114 active site 590998010115 phosphoglucomutase; Validated; Region: PRK07564 590998010116 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 590998010117 active site 590998010118 substrate binding site [chemical binding]; other site 590998010119 metal binding site [ion binding]; metal-binding site 590998010120 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 590998010121 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 590998010122 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 590998010123 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 590998010124 Hyaluronan synthases catalyze polymerization of hyaluronan; Region: GT2_HAS; cd06434 590998010125 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 590998010126 DXD motif; other site 590998010127 Predicted acetyltransferase [General function prediction only]; Region: COG2388 590998010128 Major Facilitator Superfamily; Region: MFS_1; pfam07690 590998010129 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 590998010130 Phosphotransferase enzyme family; Region: APH; pfam01636 590998010131 active site 590998010132 substrate binding site [chemical binding]; other site 590998010133 ATP binding site [chemical binding]; other site 590998010134 enterobactin exporter EntS; Provisional; Region: PRK10489 590998010135 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 590998010136 AAA domain; Region: AAA_33; pfam13671 590998010137 ATP-binding site [chemical binding]; other site 590998010138 Gluconate-6-phosphate binding site [chemical binding]; other site 590998010139 amino acid transporter; Region: 2A0306; TIGR00909 590998010140 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 590998010141 nucleoside/Zn binding site; other site 590998010142 dimer interface [polypeptide binding]; other site 590998010143 catalytic motif [active] 590998010144 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 590998010145 putative hydrophobic ligand binding site [chemical binding]; other site 590998010146 alpha-galactosidase; Region: PLN02808; cl17638 590998010147 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 590998010148 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 590998010149 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 590998010150 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 590998010151 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 590998010152 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998010153 dimerization interface [polypeptide binding]; other site 590998010154 putative DNA binding site [nucleotide binding]; other site 590998010155 putative Zn2+ binding site [ion binding]; other site 590998010156 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 590998010157 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 590998010158 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 590998010159 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 590998010160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998010161 dimer interface [polypeptide binding]; other site 590998010162 conserved gate region; other site 590998010163 putative PBP binding loops; other site 590998010164 ABC-ATPase subunit interface; other site 590998010165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 590998010166 dimer interface [polypeptide binding]; other site 590998010167 conserved gate region; other site 590998010168 putative PBP binding loops; other site 590998010169 ABC-ATPase subunit interface; other site 590998010170 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 590998010171 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 590998010172 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 590998010173 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 590998010174 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 590998010175 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 590998010176 Walker A/P-loop; other site 590998010177 ATP binding site [chemical binding]; other site 590998010178 Q-loop/lid; other site 590998010179 ABC transporter signature motif; other site 590998010180 Walker B; other site 590998010181 D-loop; other site 590998010182 H-loop/switch region; other site 590998010183 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 590998010184 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 590998010185 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 590998010186 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 590998010187 Uncharacterized conserved protein [Function unknown]; Region: COG3268 590998010188 Cupin domain; Region: Cupin_2; cl17218 590998010189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 590998010190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 590998010191 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 590998010192 classical (c) SDRs; Region: SDR_c; cd05233 590998010193 NAD(P) binding site [chemical binding]; other site 590998010194 active site 590998010195 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 590998010196 inhibitor binding site; inhibition site 590998010197 active site 590998010198 hypothetical protein; Provisional; Region: PRK02237 590998010199 Transcriptional regulators [Transcription]; Region: MarR; COG1846 590998010200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998010201 putative DNA binding site [nucleotide binding]; other site 590998010202 dimerization interface [polypeptide binding]; other site 590998010203 putative Zn2+ binding site [ion binding]; other site 590998010204 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 590998010205 Low molecular weight phosphatase family; Region: LMWPc; cl00105 590998010206 active site 590998010207 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 590998010208 Low molecular weight phosphatase family; Region: LMWPc; cd00115 590998010209 active site 590998010210 Methyltransferase domain; Region: Methyltransf_31; pfam13847 590998010211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998010212 S-adenosylmethionine binding site [chemical binding]; other site 590998010213 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998010214 dimerization interface [polypeptide binding]; other site 590998010215 putative DNA binding site [nucleotide binding]; other site 590998010216 putative Zn2+ binding site [ion binding]; other site 590998010217 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 590998010218 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 590998010219 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 590998010220 Uncharacterized conserved protein [Function unknown]; Region: COG1284 590998010221 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 590998010222 Secretory lipase; Region: LIP; pfam03583 590998010223 PAS fold; Region: PAS_4; pfam08448 590998010224 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 590998010225 putative active site [active] 590998010226 heme pocket [chemical binding]; other site 590998010227 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 590998010228 PAS domain; Region: PAS_9; pfam13426 590998010229 putative active site [active] 590998010230 heme pocket [chemical binding]; other site 590998010231 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 590998010232 PAS domain; Region: PAS_9; pfam13426 590998010233 putative active site [active] 590998010234 heme pocket [chemical binding]; other site 590998010235 PAS domain S-box; Region: sensory_box; TIGR00229 590998010236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 590998010237 putative active site [active] 590998010238 heme pocket [chemical binding]; other site 590998010239 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 590998010240 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 590998010241 metal binding site [ion binding]; metal-binding site 590998010242 active site 590998010243 I-site; other site 590998010244 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 590998010245 Methyltransferase domain; Region: Methyltransf_23; pfam13489 590998010246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 590998010247 S-adenosylmethionine binding site [chemical binding]; other site 590998010248 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 590998010249 FAD binding domain; Region: FAD_binding_4; pfam01565 590998010250 Berberine and berberine like; Region: BBE; pfam08031 590998010251 RNA polymerase sigma factor; Reviewed; Region: PRK05602 590998010252 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998010253 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 590998010254 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 590998010255 DNA binding residues [nucleotide binding] 590998010256 dimer interface [polypeptide binding]; other site 590998010257 metal binding site [ion binding]; metal-binding site 590998010258 mercuric reductase; Region: MerA; TIGR02053 590998010259 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 590998010260 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 590998010261 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 590998010262 catalytic residues [active] 590998010263 catalytic nucleophile [active] 590998010264 Presynaptic Site I dimer interface [polypeptide binding]; other site 590998010265 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 590998010266 Synaptic Flat tetramer interface [polypeptide binding]; other site 590998010267 Synaptic Site I dimer interface [polypeptide binding]; other site 590998010268 DNA binding site [nucleotide binding] 590998010269 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 590998010270 DNA-binding interface [nucleotide binding]; DNA binding site 590998010271 Helix-turn-helix domain; Region: HTH_38; pfam13936 590998010272 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 590998010273 Homeodomain-like domain; Region: HTH_32; pfam13565 590998010274 Integrase core domain; Region: rve; pfam00665 590998010275 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 590998010276 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 590998010277 FAD binding pocket [chemical binding]; other site 590998010278 FAD binding motif [chemical binding]; other site 590998010279 phosphate binding motif [ion binding]; other site 590998010280 NAD binding pocket [chemical binding]; other site 590998010281 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 590998010282 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 590998010283 ABC-ATPase subunit interface; other site 590998010284 dimer interface [polypeptide binding]; other site 590998010285 putative PBP binding regions; other site 590998010286 FecCD transport family; Region: FecCD; pfam01032 590998010287 ABC-ATPase subunit interface; other site 590998010288 dimer interface [polypeptide binding]; other site 590998010289 putative PBP binding regions; other site 590998010290 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 590998010291 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 590998010292 siderophore binding site; other site 590998010293 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 590998010294 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 590998010295 Walker A/P-loop; other site 590998010296 ATP binding site [chemical binding]; other site 590998010297 Q-loop/lid; other site 590998010298 ABC transporter signature motif; other site 590998010299 Walker B; other site 590998010300 D-loop; other site 590998010301 H-loop/switch region; other site 590998010302 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 590998010303 diiron binding motif [ion binding]; other site 590998010304 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 590998010305 NYN domain; Region: NYN; pfam01936 590998010306 Uncharacterized conserved protein [Function unknown]; Region: COG1432 590998010307 putative metal binding site [ion binding]; other site 590998010308 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 590998010309 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 590998010310 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 590998010311 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 590998010312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 590998010313 ATP binding site [chemical binding]; other site 590998010314 Mg2+ binding site [ion binding]; other site 590998010315 G-X-G motif; other site 590998010316 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998010317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 590998010318 active site 590998010319 phosphorylation site [posttranslational modification] 590998010320 intermolecular recognition site; other site 590998010321 dimerization interface [polypeptide binding]; other site 590998010322 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998010323 DNA binding residues [nucleotide binding] 590998010324 dimerization interface [polypeptide binding]; other site 590998010325 hypothetical protein; Provisional; Region: PRK06753 590998010326 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 590998010327 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 590998010328 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 590998010329 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 590998010330 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 590998010331 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 590998010332 NADP binding site [chemical binding]; other site 590998010333 Predicted transcriptional regulators [Transcription]; Region: COG1733 590998010334 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 590998010335 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 590998010336 dimer interface [polypeptide binding]; other site 590998010337 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 590998010338 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 590998010339 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 590998010340 catalytic residues [active] 590998010341 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 590998010342 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 590998010343 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 590998010344 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 590998010345 elongation factor G; Reviewed; Region: PRK12740 590998010346 G1 box; other site 590998010347 putative GEF interaction site [polypeptide binding]; other site 590998010348 GTP/Mg2+ binding site [chemical binding]; other site 590998010349 Switch I region; other site 590998010350 G2 box; other site 590998010351 G3 box; other site 590998010352 Switch II region; other site 590998010353 G4 box; other site 590998010354 G5 box; other site 590998010355 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 590998010356 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 590998010357 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 590998010358 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 590998010359 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 590998010360 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 590998010361 Fe-S cluster binding site [ion binding]; other site 590998010362 DNA binding site [nucleotide binding] 590998010363 active site 590998010364 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 590998010365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 590998010366 putative substrate translocation pore; other site 590998010367 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 590998010368 Domain of unknown function (DUF385); Region: DUF385; pfam04075 590998010369 amino acid transporter; Region: 2A0306; TIGR00909 590998010370 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 590998010371 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 590998010372 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 590998010373 DNA binding residues [nucleotide binding] 590998010374 putative dimer interface [polypeptide binding]; other site 590998010375 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 590998010376 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 590998010377 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 590998010378 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 590998010379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998010380 Walker A/P-loop; other site 590998010381 ATP binding site [chemical binding]; other site 590998010382 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 590998010383 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998010384 ABC transporter signature motif; other site 590998010385 Walker B; other site 590998010386 D-loop; other site 590998010387 H-loop/switch region; other site 590998010388 exonuclease SbcD; Region: sbcd; TIGR00619 590998010389 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 590998010390 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 590998010391 anti sigma factor interaction site; other site 590998010392 regulatory phosphorylation site [posttranslational modification]; other site 590998010393 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 590998010394 putative deacylase active site [active] 590998010395 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 590998010396 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 590998010397 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 590998010398 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 590998010399 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 590998010400 ATP binding site [chemical binding]; other site 590998010401 putative Mg++ binding site [ion binding]; other site 590998010402 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 590998010403 nucleotide binding region [chemical binding]; other site 590998010404 ATP-binding site [chemical binding]; other site 590998010405 Helicase associated domain (HA2); Region: HA2; pfam04408 590998010406 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 590998010407 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 590998010408 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 590998010409 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 590998010410 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 590998010411 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998010412 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 590998010413 Walker A/P-loop; other site 590998010414 ATP binding site [chemical binding]; other site 590998010415 Q-loop/lid; other site 590998010416 ABC transporter signature motif; other site 590998010417 Walker B; other site 590998010418 D-loop; other site 590998010419 H-loop/switch region; other site 590998010420 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 590998010421 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 590998010422 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 590998010423 FAD binding site [chemical binding]; other site 590998010424 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 590998010425 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 590998010426 THF binding site; other site 590998010427 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 590998010428 substrate binding site [chemical binding]; other site 590998010429 THF binding site; other site 590998010430 zinc-binding site [ion binding]; other site 590998010431 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 590998010432 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 590998010433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998010434 homodimer interface [polypeptide binding]; other site 590998010435 catalytic residue [active] 590998010436 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 590998010437 active site 590998010438 8-oxo-dGMP binding site [chemical binding]; other site 590998010439 nudix motif; other site 590998010440 metal binding site [ion binding]; metal-binding site 590998010441 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 590998010442 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 590998010443 DNA binding residues [nucleotide binding] 590998010444 dimerization interface [polypeptide binding]; other site 590998010445 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 590998010446 lipoyl attachment site [posttranslational modification]; other site 590998010447 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 590998010448 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 590998010449 glycine dehydrogenase; Provisional; Region: PRK05367 590998010450 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 590998010451 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 590998010452 catalytic residue [active] 590998010453 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 590998010454 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 590998010455 catalytic residue [active] 590998010456 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 590998010457 MPT binding site; other site 590998010458 trimer interface [polypeptide binding]; other site 590998010459 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 590998010460 MoaE homodimer interface [polypeptide binding]; other site 590998010461 MoaD interaction [polypeptide binding]; other site 590998010462 active site residues [active] 590998010463 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 590998010464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 590998010465 FeS/SAM binding site; other site 590998010466 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 590998010467 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 590998010468 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 590998010469 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 590998010470 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 590998010471 Histidine kinase; Region: HisKA_3; pfam07730 590998010472 Ubiquitin-like proteins; Region: UBQ; cl00155 590998010473 charged pocket; other site 590998010474 hydrophobic patch; other site 590998010475 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 590998010476 trimer interface [polypeptide binding]; other site 590998010477 dimer interface [polypeptide binding]; other site 590998010478 putative active site [active] 590998010479 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 590998010480 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 590998010481 dimer interface [polypeptide binding]; other site 590998010482 putative functional site; other site 590998010483 putative MPT binding site; other site 590998010484 hypothetical protein; Validated; Region: PRK07411 590998010485 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 590998010486 ATP binding site [chemical binding]; other site 590998010487 substrate interface [chemical binding]; other site 590998010488 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 590998010489 active site residue [active] 590998010490 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 590998010491 aspartate aminotransferase; Provisional; Region: PRK05764 590998010492 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 590998010493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998010494 homodimer interface [polypeptide binding]; other site 590998010495 catalytic residue [active] 590998010496 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 590998010497 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 590998010498 oligomer interface [polypeptide binding]; other site 590998010499 metal binding site [ion binding]; metal-binding site 590998010500 metal binding site [ion binding]; metal-binding site 590998010501 putative Cl binding site [ion binding]; other site 590998010502 basic sphincter; other site 590998010503 hydrophobic gate; other site 590998010504 periplasmic entrance; other site 590998010505 Low molecular weight phosphatase family; Region: LMWPc; cd00115 590998010506 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 590998010507 active site 590998010508 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 590998010509 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 590998010510 Predicted transcriptional regulators [Transcription]; Region: COG1695 590998010511 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 590998010512 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 590998010513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998010514 Walker A/P-loop; other site 590998010515 ATP binding site [chemical binding]; other site 590998010516 Q-loop/lid; other site 590998010517 ABC transporter signature motif; other site 590998010518 Walker B; other site 590998010519 D-loop; other site 590998010520 H-loop/switch region; other site 590998010521 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 590998010522 ABC-2 type transporter; Region: ABC2_membrane; cl17235 590998010523 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 590998010524 ABC-2 type transporter; Region: ABC2_membrane; cl17235 590998010525 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 590998010526 active site 590998010527 CHAT domain; Region: CHAT; cl17868 590998010528 VanZ like family; Region: VanZ; cl01971 590998010529 haloalkane dehalogenase; Provisional; Region: PRK03204 590998010530 Predicted transcriptional regulators [Transcription]; Region: COG1733 590998010531 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 590998010532 dimerization interface [polypeptide binding]; other site 590998010533 putative DNA binding site [nucleotide binding]; other site 590998010534 putative Zn2+ binding site [ion binding]; other site 590998010535 Yqey-like protein; Region: YqeY; pfam09424 590998010536 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 590998010537 synthetase active site [active] 590998010538 NTP binding site [chemical binding]; other site 590998010539 metal binding site [ion binding]; metal-binding site 590998010540 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 590998010541 intersubunit interface [polypeptide binding]; other site 590998010542 active site 590998010543 Zn2+ binding site [ion binding]; other site 590998010544 nitrite reductase subunit NirD; Provisional; Region: PRK14989 590998010545 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 590998010546 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 590998010547 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 590998010548 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 590998010549 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 590998010550 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 590998010551 protease 4; Provisional; Region: PRK10949 590998010552 DNA methylase; Region: N6_N4_Mtase; pfam01555 590998010553 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 590998010554 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 590998010555 DNA methylase; Region: N6_N4_Mtase; pfam01555 590998010556 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 590998010557 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 590998010558 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 590998010559 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 590998010560 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 590998010561 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 590998010562 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 590998010563 Transcriptional regulators [Transcription]; Region: PurR; COG1609 590998010564 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 590998010565 DNA binding site [nucleotide binding] 590998010566 domain linker motif; other site 590998010567 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 590998010568 dimerization interface [polypeptide binding]; other site 590998010569 ligand binding site [chemical binding]; other site 590998010570 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 590998010571 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 590998010572 Interdomain contacts; other site 590998010573 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 590998010574 metal binding site [ion binding]; metal-binding site 590998010575 ligand binding site [chemical binding]; other site 590998010576 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 590998010577 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 590998010578 Walker A/P-loop; other site 590998010579 ATP binding site [chemical binding]; other site 590998010580 Q-loop/lid; other site 590998010581 ABC transporter signature motif; other site 590998010582 Walker B; other site 590998010583 D-loop; other site 590998010584 H-loop/switch region; other site 590998010585 ABC transporter; Region: ABC_tran_2; pfam12848 590998010586 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 590998010587 Amb_all domain; Region: Amb_all; smart00656 590998010588 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 590998010589 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 590998010590 oligomer interface [polypeptide binding]; other site 590998010591 active site residues [active] 590998010592 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 590998010593 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 590998010594 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 590998010595 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 590998010596 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 590998010597 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 590998010598 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 590998010599 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 590998010600 dimer interface [polypeptide binding]; other site 590998010601 ssDNA binding site [nucleotide binding]; other site 590998010602 tetramer (dimer of dimers) interface [polypeptide binding]; other site 590998010603 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 590998010604 Transglycosylase; Region: Transgly; pfam00912 590998010605 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 590998010606 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 590998010607 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 590998010608 Predicted transcriptional regulators [Transcription]; Region: COG1695 590998010609 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 590998010610 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 590998010611 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 590998010612 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 590998010613 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 590998010614 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 590998010615 DNA binding residues [nucleotide binding] 590998010616 H+ Antiporter protein; Region: 2A0121; TIGR00900 590998010617 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 590998010618 putative active site [active] 590998010619 heme pocket [chemical binding]; other site 590998010620 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 590998010621 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 590998010622 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 590998010623 active site 590998010624 NTP binding site [chemical binding]; other site 590998010625 metal binding triad [ion binding]; metal-binding site 590998010626 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 590998010627 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 590998010628 Zn2+ binding site [ion binding]; other site 590998010629 Mg2+ binding site [ion binding]; other site 590998010630 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 590998010631 active site 590998010632 Ap6A binding site [chemical binding]; other site 590998010633 nudix motif; other site 590998010634 metal binding site [ion binding]; metal-binding site 590998010635 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 590998010636 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 590998010637 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 590998010638 ATP binding site [chemical binding]; other site 590998010639 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 590998010640 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 590998010641 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 590998010642 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 590998010643 catalytic residues [active] 590998010644 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 590998010645 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 590998010646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 590998010647 homodimer interface [polypeptide binding]; other site 590998010648 catalytic residue [active] 590998010649 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 590998010650 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 590998010651 ATP-grasp domain; Region: ATP-grasp_4; cl17255 590998010652 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 590998010653 ParB-like nuclease domain; Region: ParB; smart00470 590998010654 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 590998010655 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 590998010656 Magnesium ion binding site [ion binding]; other site 590998010657 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 590998010658 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 590998010659 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 590998010660 G-X-X-G motif; other site 590998010661 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 590998010662 RxxxH motif; other site 590998010663 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 590998010664 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 590998010665 Haemolytic domain; Region: Haemolytic; pfam01809 590998010666 Ribonuclease P; Region: Ribonuclease_P; cl00457 590998010667 Ribosomal protein L34; Region: Ribosomal_L34; cl00370