-- dump date 20140619_025809 -- class Genbank::misc_feature -- table misc_feature_note -- id note 208596000001 AAA domain; Region: AAA_31; pfam13614 208596000002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 208596000003 P-loop; other site 208596000004 Magnesium ion binding site [ion binding]; other site 208596000005 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 208596000006 Magnesium ion binding site [ion binding]; other site 208596000007 Fic family protein [Function unknown]; Region: COG3177 208596000008 Fic/DOC family; Region: Fic; pfam02661 208596000009 multiple promoter invertase; Provisional; Region: mpi; PRK13413 208596000010 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 208596000011 catalytic residues [active] 208596000012 catalytic nucleophile [active] 208596000013 Presynaptic Site I dimer interface [polypeptide binding]; other site 208596000014 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 208596000015 Synaptic Flat tetramer interface [polypeptide binding]; other site 208596000016 Synaptic Site I dimer interface [polypeptide binding]; other site 208596000017 DNA binding site [nucleotide binding] 208596000018 HTH domain; Region: HTH_11; pfam08279 208596000019 putative frv operon regulatory protein; Provisional; Region: PRK09863 208596000020 PRD domain; Region: PRD; pfam00874 208596000021 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 208596000022 active site 208596000023 phosphorylation site [posttranslational modification] 208596000024 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 208596000025 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 208596000026 intersubunit interface [polypeptide binding]; other site 208596000027 active site 208596000028 zinc binding site [ion binding]; other site 208596000029 Na+ binding site [ion binding]; other site 208596000030 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 208596000031 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 208596000032 active site 208596000033 phosphorylation site [posttranslational modification] 208596000034 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 208596000035 active site 208596000036 P-loop; other site 208596000037 phosphorylation site [posttranslational modification] 208596000038 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 208596000039 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 208596000040 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 208596000041 putative active site cavity [active] 208596000042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596000043 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 208596000044 active site 208596000045 motif I; other site 208596000046 motif II; other site 208596000047 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 208596000048 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 208596000049 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 208596000050 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 208596000051 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 208596000052 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 208596000053 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 208596000054 putative active site [active] 208596000055 hypothetical protein; Provisional; Region: PRK02947 208596000056 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 208596000057 putative active site [active] 208596000058 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 208596000059 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 208596000060 active site 208596000061 P-loop; other site 208596000062 phosphorylation site [posttranslational modification] 208596000063 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 208596000064 active site 208596000065 phosphorylation site [posttranslational modification] 208596000066 PRD domain; Region: PRD; pfam00874 208596000067 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 208596000068 active site 208596000069 P-loop; other site 208596000070 phosphorylation site [posttranslational modification] 208596000071 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 208596000072 active site 208596000073 phosphorylation site [posttranslational modification] 208596000074 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 208596000075 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 208596000076 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 208596000077 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 208596000078 DNA binding residues [nucleotide binding] 208596000079 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 208596000080 nudix motif; other site 208596000081 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 208596000082 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 208596000083 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 208596000084 active site 208596000085 DNA binding site [nucleotide binding] 208596000086 Int/Topo IB signature motif; other site 208596000087 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 208596000088 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 208596000089 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 208596000090 Mechanosensitive ion channel; Region: MS_channel; pfam00924 208596000091 Predicted membrane protein [Function unknown]; Region: COG2323 208596000092 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 208596000093 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 208596000094 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 208596000095 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208596000096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596000097 non-specific DNA binding site [nucleotide binding]; other site 208596000098 salt bridge; other site 208596000099 sequence-specific DNA binding site [nucleotide binding]; other site 208596000100 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 208596000101 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208596000102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596000103 non-specific DNA binding site [nucleotide binding]; other site 208596000104 salt bridge; other site 208596000105 sequence-specific DNA binding site [nucleotide binding]; other site 208596000106 CAAX protease self-immunity; Region: Abi; pfam02517 208596000107 YcxB-like protein; Region: YcxB; pfam14317 208596000108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 208596000109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596000110 Coenzyme A binding pocket [chemical binding]; other site 208596000111 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 208596000112 Predicted transcriptional regulators [Transcription]; Region: COG1695 208596000113 Transcriptional regulator PadR-like family; Region: PadR; cl17335 208596000114 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 208596000115 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 208596000116 catalytic triad [active] 208596000117 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 208596000118 DnaA N-terminal domain; Region: DnaA_N; pfam11638 208596000119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208596000120 Walker A motif; other site 208596000121 ATP binding site [chemical binding]; other site 208596000122 Walker B motif; other site 208596000123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 208596000124 arginine finger; other site 208596000125 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 208596000126 DnaA box-binding interface [nucleotide binding]; other site 208596000127 DNA polymerase III subunit beta; Validated; Region: PRK05643 208596000128 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 208596000129 putative DNA binding surface [nucleotide binding]; other site 208596000130 dimer interface [polypeptide binding]; other site 208596000131 beta-clamp/clamp loader binding surface; other site 208596000132 beta-clamp/translesion DNA polymerase binding surface; other site 208596000133 S4 domain; Region: S4_2; pfam13275 208596000134 recombination protein F; Reviewed; Region: recF; PRK00064 208596000135 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 208596000136 Walker A/P-loop; other site 208596000137 ATP binding site [chemical binding]; other site 208596000138 Q-loop/lid; other site 208596000139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596000140 ABC transporter signature motif; other site 208596000141 Walker B; other site 208596000142 D-loop; other site 208596000143 H-loop/switch region; other site 208596000144 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 208596000145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208596000146 Mg2+ binding site [ion binding]; other site 208596000147 G-X-G motif; other site 208596000148 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 208596000149 anchoring element; other site 208596000150 dimer interface [polypeptide binding]; other site 208596000151 ATP binding site [chemical binding]; other site 208596000152 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 208596000153 active site 208596000154 putative metal-binding site [ion binding]; other site 208596000155 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 208596000156 DNA gyrase subunit A; Validated; Region: PRK05560 208596000157 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 208596000158 CAP-like domain; other site 208596000159 active site 208596000160 primary dimer interface [polypeptide binding]; other site 208596000161 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 208596000162 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 208596000163 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 208596000164 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 208596000165 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 208596000166 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 208596000167 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 208596000168 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 208596000169 dimer interface [polypeptide binding]; other site 208596000170 ssDNA binding site [nucleotide binding]; other site 208596000171 tetramer (dimer of dimers) interface [polypeptide binding]; other site 208596000172 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 208596000173 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 208596000174 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208596000175 active site 208596000176 metal binding site [ion binding]; metal-binding site 208596000177 I-site; other site 208596000178 DHH family; Region: DHH; pfam01368 208596000179 DHHA1 domain; Region: DHHA1; pfam02272 208596000180 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 208596000181 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 208596000182 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 208596000183 replicative DNA helicase; Provisional; Region: PRK05748 208596000184 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 208596000185 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 208596000186 Walker A motif; other site 208596000187 ATP binding site [chemical binding]; other site 208596000188 Walker B motif; other site 208596000189 DNA binding loops [nucleotide binding] 208596000190 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 208596000191 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 208596000192 GDP-binding site [chemical binding]; other site 208596000193 ACT binding site; other site 208596000194 IMP binding site; other site 208596000195 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 208596000196 Domain of unknown function (DUF378); Region: DUF378; pfam04070 208596000197 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 208596000198 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 208596000199 active site 208596000200 Na/Ca binding site [ion binding]; other site 208596000201 catalytic site [active] 208596000202 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 208596000203 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 208596000204 substrate binding site [chemical binding]; other site 208596000205 multimerization interface [polypeptide binding]; other site 208596000206 ATP binding site [chemical binding]; other site 208596000207 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 208596000208 dimer interface [polypeptide binding]; other site 208596000209 substrate binding site [chemical binding]; other site 208596000210 ATP binding site [chemical binding]; other site 208596000211 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 208596000212 active site 208596000213 thiamine phosphate binding site [chemical binding]; other site 208596000214 pyrophosphate binding site [ion binding]; other site 208596000215 YtxH-like protein; Region: YtxH; pfam12732 208596000216 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 208596000217 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 208596000218 HPr interaction site; other site 208596000219 glycerol kinase (GK) interaction site [polypeptide binding]; other site 208596000220 active site 208596000221 phosphorylation site [posttranslational modification] 208596000222 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208596000223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208596000224 active site 208596000225 phosphorylation site [posttranslational modification] 208596000226 intermolecular recognition site; other site 208596000227 dimerization interface [polypeptide binding]; other site 208596000228 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208596000229 DNA binding site [nucleotide binding] 208596000230 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 208596000231 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208596000232 dimerization interface [polypeptide binding]; other site 208596000233 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208596000234 putative active site [active] 208596000235 heme pocket [chemical binding]; other site 208596000236 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208596000237 dimer interface [polypeptide binding]; other site 208596000238 phosphorylation site [posttranslational modification] 208596000239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208596000240 ATP binding site [chemical binding]; other site 208596000241 Mg2+ binding site [ion binding]; other site 208596000242 G-X-G motif; other site 208596000243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 208596000244 YycH protein; Region: YycH; pfam07435 208596000245 YycH protein; Region: YycI; pfam09648 208596000246 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 208596000247 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 208596000248 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 208596000249 protein binding site [polypeptide binding]; other site 208596000250 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 208596000251 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 208596000252 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 208596000253 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 208596000254 dimer interface [polypeptide binding]; other site 208596000255 active site 208596000256 metal binding site [ion binding]; metal-binding site 208596000257 glutathione binding site [chemical binding]; other site 208596000258 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 208596000259 putative S-transferase; Provisional; Region: PRK11752 208596000260 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 208596000261 C-terminal domain interface [polypeptide binding]; other site 208596000262 GSH binding site (G-site) [chemical binding]; other site 208596000263 dimer interface [polypeptide binding]; other site 208596000264 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 208596000265 dimer interface [polypeptide binding]; other site 208596000266 N-terminal domain interface [polypeptide binding]; other site 208596000267 active site 208596000268 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 208596000269 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 208596000270 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 208596000271 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 208596000272 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 208596000273 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 208596000274 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 208596000275 A new structural DNA glycosylase; Region: AlkD_like; cd06561 208596000276 active site 208596000277 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 208596000278 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 208596000279 PGAP1-like protein; Region: PGAP1; pfam07819 208596000280 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 208596000281 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 208596000282 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 208596000283 dimer interface [polypeptide binding]; other site 208596000284 active site 208596000285 CoA binding pocket [chemical binding]; other site 208596000286 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 208596000287 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 208596000288 Protein of unknown function, DUF488; Region: DUF488; pfam04343 208596000289 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 208596000290 Telomere-binding protein beta subunit (TEBP beta); Region: TEBP_beta; pfam07404 208596000291 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 208596000292 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 208596000293 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 208596000294 cytosine deaminase; Provisional; Region: PRK05985 208596000295 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 208596000296 active site 208596000297 membrane protein FdrA; Validated; Region: PRK06091 208596000298 CoA binding domain; Region: CoA_binding; pfam02629 208596000299 CoA-ligase; Region: Ligase_CoA; pfam00549 208596000300 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 208596000301 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 208596000302 BCCT family transporter; Region: BCCT; pfam02028 208596000303 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 208596000304 nudix motif; other site 208596000305 uracil transporter; Provisional; Region: PRK10720 208596000306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208596000307 H+ Antiporter protein; Region: 2A0121; TIGR00900 208596000308 putative substrate translocation pore; other site 208596000309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 208596000310 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 208596000311 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 208596000312 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 208596000313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 208596000314 Domain of unknown function (DUF1846); Region: DUF1846; pfam08903 208596000315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208596000316 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 208596000317 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 208596000318 NlpC/P60 family; Region: NLPC_P60; pfam00877 208596000319 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 208596000320 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 208596000321 peptide binding site [polypeptide binding]; other site 208596000322 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 208596000323 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596000324 Walker A/P-loop; other site 208596000325 ATP binding site [chemical binding]; other site 208596000326 Q-loop/lid; other site 208596000327 ABC transporter signature motif; other site 208596000328 Walker B; other site 208596000329 D-loop; other site 208596000330 H-loop/switch region; other site 208596000331 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 208596000332 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 208596000333 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 208596000334 MepB protein; Region: MepB; pfam08877 208596000335 DinB superfamily; Region: DinB_2; pfam12867 208596000336 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208596000337 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596000338 sequence-specific DNA binding site [nucleotide binding]; other site 208596000339 salt bridge; other site 208596000340 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208596000341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596000342 non-specific DNA binding site [nucleotide binding]; other site 208596000343 salt bridge; other site 208596000344 sequence-specific DNA binding site [nucleotide binding]; other site 208596000345 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 208596000346 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208596000347 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596000348 non-specific DNA binding site [nucleotide binding]; other site 208596000349 salt bridge; other site 208596000350 sequence-specific DNA binding site [nucleotide binding]; other site 208596000351 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 208596000352 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208596000353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596000354 non-specific DNA binding site [nucleotide binding]; other site 208596000355 salt bridge; other site 208596000356 sequence-specific DNA binding site [nucleotide binding]; other site 208596000357 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596000358 sequence-specific DNA binding site [nucleotide binding]; other site 208596000359 salt bridge; other site 208596000360 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 208596000361 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 208596000362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596000363 Walker A/P-loop; other site 208596000364 ATP binding site [chemical binding]; other site 208596000365 Q-loop/lid; other site 208596000366 ABC transporter signature motif; other site 208596000367 Walker B; other site 208596000368 D-loop; other site 208596000369 H-loop/switch region; other site 208596000370 Integral membrane protein DUF95; Region: DUF95; pfam01944 208596000371 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 208596000372 HlyD family secretion protein; Region: HlyD_3; pfam13437 208596000373 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 208596000374 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 208596000375 Walker A/P-loop; other site 208596000376 ATP binding site [chemical binding]; other site 208596000377 Q-loop/lid; other site 208596000378 ABC transporter signature motif; other site 208596000379 Walker B; other site 208596000380 D-loop; other site 208596000381 H-loop/switch region; other site 208596000382 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 208596000383 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 208596000384 FtsX-like permease family; Region: FtsX; pfam02687 208596000385 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 208596000386 active site 208596000387 DNA binding site [nucleotide binding] 208596000388 Int/Topo IB signature motif; other site 208596000389 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 208596000390 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 208596000391 nudix motif; other site 208596000392 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208596000393 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596000394 non-specific DNA binding site [nucleotide binding]; other site 208596000395 salt bridge; other site 208596000396 sequence-specific DNA binding site [nucleotide binding]; other site 208596000397 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 208596000398 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208596000399 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596000400 non-specific DNA binding site [nucleotide binding]; other site 208596000401 salt bridge; other site 208596000402 sequence-specific DNA binding site [nucleotide binding]; other site 208596000403 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 208596000404 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 208596000405 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 208596000406 Soluble P-type ATPase [General function prediction only]; Region: COG4087 208596000407 glycerol kinase; Provisional; Region: glpK; PRK00047 208596000408 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 208596000409 N- and C-terminal domain interface [polypeptide binding]; other site 208596000410 active site 208596000411 MgATP binding site [chemical binding]; other site 208596000412 catalytic site [active] 208596000413 metal binding site [ion binding]; metal-binding site 208596000414 glycerol binding site [chemical binding]; other site 208596000415 homotetramer interface [polypeptide binding]; other site 208596000416 homodimer interface [polypeptide binding]; other site 208596000417 FBP binding site [chemical binding]; other site 208596000418 protein IIAGlc interface [polypeptide binding]; other site 208596000419 glycerol kinase; Provisional; Region: glpK; PRK00047 208596000420 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 208596000421 N- and C-terminal domain interface [polypeptide binding]; other site 208596000422 active site 208596000423 MgATP binding site [chemical binding]; other site 208596000424 catalytic site [active] 208596000425 metal binding site [ion binding]; metal-binding site 208596000426 glycerol binding site [chemical binding]; other site 208596000427 homotetramer interface [polypeptide binding]; other site 208596000428 homodimer interface [polypeptide binding]; other site 208596000429 FBP binding site [chemical binding]; other site 208596000430 protein IIAGlc interface [polypeptide binding]; other site 208596000431 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 208596000432 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 208596000433 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 208596000434 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 208596000435 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 208596000436 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 208596000437 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 208596000438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596000439 Walker A/P-loop; other site 208596000440 ATP binding site [chemical binding]; other site 208596000441 Q-loop/lid; other site 208596000442 ABC transporter signature motif; other site 208596000443 Walker B; other site 208596000444 D-loop; other site 208596000445 H-loop/switch region; other site 208596000446 ABC transporter; Region: ABC_tran_2; pfam12848 208596000447 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 208596000448 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208596000449 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208596000450 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 208596000451 Haemolytic domain; Region: Haemolytic; pfam01809 208596000452 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 208596000453 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 208596000454 active site 208596000455 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 208596000456 NADH(P)-binding; Region: NAD_binding_10; pfam13460 208596000457 NAD(P) binding site [chemical binding]; other site 208596000458 putative active site [active] 208596000459 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 208596000460 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 208596000461 NAD binding site [chemical binding]; other site 208596000462 catalytic Zn binding site [ion binding]; other site 208596000463 structural Zn binding site [ion binding]; other site 208596000464 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 208596000465 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 208596000466 active site 208596000467 HIGH motif; other site 208596000468 dimer interface [polypeptide binding]; other site 208596000469 KMSKS motif; other site 208596000470 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 208596000471 RNA binding surface [nucleotide binding]; other site 208596000472 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208596000473 Predicted transcriptional regulators [Transcription]; Region: COG1510 208596000474 putative DNA binding site [nucleotide binding]; other site 208596000475 putative Zn2+ binding site [ion binding]; other site 208596000476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208596000477 H+ Antiporter protein; Region: 2A0121; TIGR00900 208596000478 putative substrate translocation pore; other site 208596000479 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 208596000480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596000481 Coenzyme A binding pocket [chemical binding]; other site 208596000482 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 208596000483 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 208596000484 active site 208596000485 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 208596000486 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 208596000487 active site turn [active] 208596000488 phosphorylation site [posttranslational modification] 208596000489 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 208596000490 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 208596000491 HPr interaction site; other site 208596000492 glycerol kinase (GK) interaction site [polypeptide binding]; other site 208596000493 active site 208596000494 phosphorylation site [posttranslational modification] 208596000495 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 208596000496 beta-galactosidase; Region: BGL; TIGR03356 208596000497 N-glycosyltransferase; Provisional; Region: PRK11204 208596000498 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 208596000499 DXD motif; other site 208596000500 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 208596000501 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208596000502 putative DNA binding site [nucleotide binding]; other site 208596000503 putative Zn2+ binding site [ion binding]; other site 208596000504 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 208596000505 dimer interface [polypeptide binding]; other site 208596000506 FMN binding site [chemical binding]; other site 208596000507 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 208596000508 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 208596000509 Peptidase family M23; Region: Peptidase_M23; pfam01551 208596000510 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 208596000511 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208596000512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596000513 non-specific DNA binding site [nucleotide binding]; other site 208596000514 salt bridge; other site 208596000515 sequence-specific DNA binding site [nucleotide binding]; other site 208596000516 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 208596000517 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 208596000518 Sulfate transporter family; Region: Sulfate_transp; pfam00916 208596000519 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 208596000520 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 208596000521 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 208596000522 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 208596000523 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 208596000524 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 208596000525 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 208596000526 Predicted transcriptional regulators [Transcription]; Region: COG1733 208596000527 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208596000528 putative DNA binding site [nucleotide binding]; other site 208596000529 dimerization interface [polypeptide binding]; other site 208596000530 putative Zn2+ binding site [ion binding]; other site 208596000531 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 208596000532 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 208596000533 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 208596000534 substrate binding site [chemical binding]; other site 208596000535 catalytic Zn binding site [ion binding]; other site 208596000536 NAD binding site [chemical binding]; other site 208596000537 structural Zn binding site [ion binding]; other site 208596000538 dimer interface [polypeptide binding]; other site 208596000539 S-formylglutathione hydrolase; Region: PLN02442 208596000540 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 208596000541 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 208596000542 Domain of unknown function DUF20; Region: UPF0118; pfam01594 208596000543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596000544 Coenzyme A binding pocket [chemical binding]; other site 208596000545 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 208596000546 fructuronate transporter; Provisional; Region: PRK10034; cl15264 208596000547 glycerate kinase; Region: TIGR00045 208596000548 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 208596000549 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 208596000550 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 208596000551 putative dimer interface [polypeptide binding]; other site 208596000552 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 208596000553 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 208596000554 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 208596000555 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 208596000556 Walker A/P-loop; other site 208596000557 ATP binding site [chemical binding]; other site 208596000558 Q-loop/lid; other site 208596000559 ABC transporter signature motif; other site 208596000560 Walker B; other site 208596000561 D-loop; other site 208596000562 H-loop/switch region; other site 208596000563 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 208596000564 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208596000565 substrate binding pocket [chemical binding]; other site 208596000566 membrane-bound complex binding site; other site 208596000567 hinge residues; other site 208596000568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596000569 dimer interface [polypeptide binding]; other site 208596000570 conserved gate region; other site 208596000571 putative PBP binding loops; other site 208596000572 ABC-ATPase subunit interface; other site 208596000573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596000574 dimer interface [polypeptide binding]; other site 208596000575 conserved gate region; other site 208596000576 putative PBP binding loops; other site 208596000577 ABC-ATPase subunit interface; other site 208596000578 Protein of unknown function DUF72; Region: DUF72; pfam01904 208596000579 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596000580 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 208596000581 active site 208596000582 motif I; other site 208596000583 motif II; other site 208596000584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596000585 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 208596000586 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 208596000587 active site 208596000588 HIGH motif; other site 208596000589 KMSKS motif; other site 208596000590 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 208596000591 tRNA binding surface [nucleotide binding]; other site 208596000592 anticodon binding site; other site 208596000593 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 208596000594 dimer interface [polypeptide binding]; other site 208596000595 putative tRNA-binding site [nucleotide binding]; other site 208596000596 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 208596000597 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 208596000598 active site 208596000599 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 208596000600 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 208596000601 putative active site [active] 208596000602 putative metal binding site [ion binding]; other site 208596000603 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 208596000604 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 208596000605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208596000606 S-adenosylmethionine binding site [chemical binding]; other site 208596000607 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 208596000608 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 208596000609 putative dimer interface [polypeptide binding]; other site 208596000610 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 208596000611 ligand binding site [chemical binding]; other site 208596000612 Zn binding site [ion binding]; other site 208596000613 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 208596000614 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 208596000615 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 208596000616 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 208596000617 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 208596000618 metal binding site [ion binding]; metal-binding site 208596000619 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 208596000620 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 208596000621 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 208596000622 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 208596000623 ABC-ATPase subunit interface; other site 208596000624 dimer interface [polypeptide binding]; other site 208596000625 putative PBP binding regions; other site 208596000626 pur operon repressor; Provisional; Region: PRK09213 208596000627 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 208596000628 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208596000629 active site 208596000630 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 208596000631 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 208596000632 Substrate binding site; other site 208596000633 Mg++ binding site; other site 208596000634 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 208596000635 active site 208596000636 substrate binding site [chemical binding]; other site 208596000637 CoA binding site [chemical binding]; other site 208596000638 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 208596000639 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 208596000640 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208596000641 active site 208596000642 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 208596000643 trimer interface [polypeptide binding]; other site 208596000644 hypothetical protein; Provisional; Region: PRK07205 208596000645 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 208596000646 active site 208596000647 metal binding site [ion binding]; metal-binding site 208596000648 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 208596000649 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 208596000650 tetramer (dimer of dimers) interface [polypeptide binding]; other site 208596000651 NAD binding site [chemical binding]; other site 208596000652 dimer interface [polypeptide binding]; other site 208596000653 substrate binding site [chemical binding]; other site 208596000654 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 208596000655 putative active site [active] 208596000656 catalytic residue [active] 208596000657 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 208596000658 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 208596000659 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208596000660 ATP binding site [chemical binding]; other site 208596000661 putative Mg++ binding site [ion binding]; other site 208596000662 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208596000663 nucleotide binding region [chemical binding]; other site 208596000664 ATP-binding site [chemical binding]; other site 208596000665 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 208596000666 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 208596000667 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 208596000668 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 208596000669 putative SAM binding site [chemical binding]; other site 208596000670 putative homodimer interface [polypeptide binding]; other site 208596000671 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 208596000672 homodimer interface [polypeptide binding]; other site 208596000673 metal binding site [ion binding]; metal-binding site 208596000674 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 208596000675 RNA binding surface [nucleotide binding]; other site 208596000676 Septum formation initiator; Region: DivIC; pfam04977 208596000677 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 208596000678 hypothetical protein; Provisional; Region: PRK08582 208596000679 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 208596000680 RNA binding site [nucleotide binding]; other site 208596000681 potential frameshift: common BLAST hit: gi|46906451|ref|YP_012840.1| hypoxanthine phosphoribosyltransferase, fusion 208596000682 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 208596000683 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 208596000684 Ligand Binding Site [chemical binding]; other site 208596000685 TilS substrate C-terminal domain; Region: TilS_C; smart00977 208596000686 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208596000687 active site 208596000688 FtsH Extracellular; Region: FtsH_ext; pfam06480 208596000689 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 208596000690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208596000691 Walker A motif; other site 208596000692 ATP binding site [chemical binding]; other site 208596000693 Walker B motif; other site 208596000694 arginine finger; other site 208596000695 Peptidase family M41; Region: Peptidase_M41; pfam01434 208596000696 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 208596000697 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 208596000698 dimerization interface [polypeptide binding]; other site 208596000699 domain crossover interface; other site 208596000700 redox-dependent activation switch; other site 208596000701 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 208596000702 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 208596000703 dimer interface [polypeptide binding]; other site 208596000704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208596000705 catalytic residue [active] 208596000706 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 208596000707 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 208596000708 dimer interface [polypeptide binding]; other site 208596000709 putative anticodon binding site; other site 208596000710 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 208596000711 motif 1; other site 208596000712 active site 208596000713 motif 2; other site 208596000714 motif 3; other site 208596000715 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 208596000716 Domain of unknown function DUF20; Region: UPF0118; pfam01594 208596000717 transcriptional antiterminator BglG; Provisional; Region: PRK09772 208596000718 CAT RNA binding domain; Region: CAT_RBD; smart01061 208596000719 PRD domain; Region: PRD; pfam00874 208596000720 PRD domain; Region: PRD; pfam00874 208596000721 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 208596000722 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 208596000723 active site turn [active] 208596000724 phosphorylation site [posttranslational modification] 208596000725 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 208596000726 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 208596000727 HPr interaction site; other site 208596000728 glycerol kinase (GK) interaction site [polypeptide binding]; other site 208596000729 active site 208596000730 phosphorylation site [posttranslational modification] 208596000731 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 208596000732 beta-galactosidase; Region: BGL; TIGR03356 208596000733 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 208596000734 beta-galactosidase; Region: BGL; TIGR03356 208596000735 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 208596000736 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 208596000737 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 208596000738 Clp amino terminal domain; Region: Clp_N; pfam02861 208596000739 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208596000740 Walker A motif; other site 208596000741 ATP binding site [chemical binding]; other site 208596000742 Walker B motif; other site 208596000743 arginine finger; other site 208596000744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208596000745 Walker A motif; other site 208596000746 ATP binding site [chemical binding]; other site 208596000747 Walker B motif; other site 208596000748 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 208596000749 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 208596000750 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 208596000751 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 208596000752 nucleoside/Zn binding site; other site 208596000753 dimer interface [polypeptide binding]; other site 208596000754 catalytic motif [active] 208596000755 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 208596000756 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 208596000757 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 208596000758 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 208596000759 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 208596000760 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 208596000761 DNA binding site [nucleotide binding] 208596000762 active site 208596000763 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 208596000764 ATP cone domain; Region: ATP-cone; pfam03477 208596000765 Class III ribonucleotide reductase; Region: RNR_III; cd01675 208596000766 effector binding site; other site 208596000767 active site 208596000768 Zn binding site [ion binding]; other site 208596000769 glycine loop; other site 208596000770 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 208596000771 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 208596000772 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 208596000773 BioY family; Region: BioY; pfam02632 208596000774 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 208596000775 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208596000776 putative DNA binding site [nucleotide binding]; other site 208596000777 putative Zn2+ binding site [ion binding]; other site 208596000778 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 208596000779 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 208596000780 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 208596000781 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 208596000782 Walker A/P-loop; other site 208596000783 ATP binding site [chemical binding]; other site 208596000784 Q-loop/lid; other site 208596000785 ABC transporter signature motif; other site 208596000786 Walker B; other site 208596000787 D-loop; other site 208596000788 H-loop/switch region; other site 208596000789 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 208596000790 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 208596000791 FtsX-like permease family; Region: FtsX; pfam02687 208596000792 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 208596000793 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 208596000794 alanine racemase; Reviewed; Region: alr; PRK00053 208596000795 active site 208596000796 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 208596000797 dimer interface [polypeptide binding]; other site 208596000798 substrate binding site [chemical binding]; other site 208596000799 catalytic residues [active] 208596000800 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 208596000801 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 208596000802 NMT1/THI5 like; Region: NMT1; pfam09084 208596000803 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 208596000804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596000805 putative PBP binding loops; other site 208596000806 ABC-ATPase subunit interface; other site 208596000807 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 208596000808 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 208596000809 Walker A/P-loop; other site 208596000810 ATP binding site [chemical binding]; other site 208596000811 Q-loop/lid; other site 208596000812 ABC transporter signature motif; other site 208596000813 Walker B; other site 208596000814 D-loop; other site 208596000815 H-loop/switch region; other site 208596000816 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 208596000817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208596000818 Walker A motif; other site 208596000819 ATP binding site [chemical binding]; other site 208596000820 Walker B motif; other site 208596000821 arginine finger; other site 208596000822 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 208596000823 hypothetical protein; Validated; Region: PRK00153 208596000824 recombination protein RecR; Reviewed; Region: recR; PRK00076 208596000825 RecR protein; Region: RecR; pfam02132 208596000826 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 208596000827 putative active site [active] 208596000828 putative metal-binding site [ion binding]; other site 208596000829 tetramer interface [polypeptide binding]; other site 208596000830 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 208596000831 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 208596000832 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 208596000833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208596000834 catalytic residue [active] 208596000835 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 208596000836 thymidylate kinase; Validated; Region: tmk; PRK00698 208596000837 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 208596000838 TMP-binding site; other site 208596000839 ATP-binding site [chemical binding]; other site 208596000840 Protein of unknown function (DUF970); Region: DUF970; pfam06153 208596000841 DNA polymerase III subunit delta'; Validated; Region: PRK08058 208596000842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208596000843 Walker A motif; other site 208596000844 ATP binding site [chemical binding]; other site 208596000845 Walker B motif; other site 208596000846 arginine finger; other site 208596000847 Protein of unknown function (DUF972); Region: DUF972; pfam06156 208596000848 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 208596000849 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 208596000850 NAD(P) binding site [chemical binding]; other site 208596000851 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 208596000852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208596000853 S-adenosylmethionine binding site [chemical binding]; other site 208596000854 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 208596000855 GIY-YIG motif/motif A; other site 208596000856 putative active site [active] 208596000857 putative metal binding site [ion binding]; other site 208596000858 Predicted methyltransferases [General function prediction only]; Region: COG0313 208596000859 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 208596000860 putative SAM binding site [chemical binding]; other site 208596000861 putative homodimer interface [polypeptide binding]; other site 208596000862 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 208596000863 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 208596000864 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 208596000865 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 208596000866 Aspartase; Region: Aspartase; cd01357 208596000867 active sites [active] 208596000868 tetramer interface [polypeptide binding]; other site 208596000869 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 208596000870 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208596000871 putative DNA binding site [nucleotide binding]; other site 208596000872 putative Zn2+ binding site [ion binding]; other site 208596000873 AsnC family; Region: AsnC_trans_reg; pfam01037 208596000874 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 208596000875 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 208596000876 putative catalytic cysteine [active] 208596000877 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 208596000878 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 208596000879 nucleotide binding site [chemical binding]; other site 208596000880 homotetrameric interface [polypeptide binding]; other site 208596000881 putative phosphate binding site [ion binding]; other site 208596000882 putative allosteric binding site; other site 208596000883 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 208596000884 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 208596000885 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 208596000886 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 208596000887 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596000888 motif II; other site 208596000889 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 208596000890 intracellular protease, PfpI family; Region: PfpI; TIGR01382 208596000891 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 208596000892 proposed catalytic triad [active] 208596000893 conserved cys residue [active] 208596000894 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 208596000895 active site 208596000896 dimer interfaces [polypeptide binding]; other site 208596000897 catalytic residues [active] 208596000898 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08115 208596000899 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 208596000900 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 208596000901 active site 208596000902 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 208596000903 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 208596000904 metal binding site [ion binding]; metal-binding site 208596000905 putative dimer interface [polypeptide binding]; other site 208596000906 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 208596000907 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 208596000908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596000909 dimer interface [polypeptide binding]; other site 208596000910 conserved gate region; other site 208596000911 ABC-ATPase subunit interface; other site 208596000912 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 208596000913 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 208596000914 Walker A/P-loop; other site 208596000915 ATP binding site [chemical binding]; other site 208596000916 Q-loop/lid; other site 208596000917 ABC transporter signature motif; other site 208596000918 Walker B; other site 208596000919 D-loop; other site 208596000920 H-loop/switch region; other site 208596000921 NIL domain; Region: NIL; pfam09383 208596000922 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 208596000923 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 208596000924 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 208596000925 nudix motif; other site 208596000926 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 208596000927 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 208596000928 active site 1 [active] 208596000929 dimer interface [polypeptide binding]; other site 208596000930 hexamer interface [polypeptide binding]; other site 208596000931 active site 2 [active] 208596000932 Predicted transcriptional regulator [Transcription]; Region: COG4189 208596000933 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208596000934 putative DNA binding site [nucleotide binding]; other site 208596000935 dimerization interface [polypeptide binding]; other site 208596000936 putative Zn2+ binding site [ion binding]; other site 208596000937 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 208596000938 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 208596000939 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 208596000940 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 208596000941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596000942 dimer interface [polypeptide binding]; other site 208596000943 conserved gate region; other site 208596000944 putative PBP binding loops; other site 208596000945 ABC-ATPase subunit interface; other site 208596000946 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 208596000947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596000948 dimer interface [polypeptide binding]; other site 208596000949 conserved gate region; other site 208596000950 putative PBP binding loops; other site 208596000951 ABC-ATPase subunit interface; other site 208596000952 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 208596000953 substrate binding site [chemical binding]; other site 208596000954 active site 208596000955 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 208596000956 active site 208596000957 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 208596000958 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 208596000959 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 208596000960 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 208596000961 putative N- and C-terminal domain interface [polypeptide binding]; other site 208596000962 putative active site [active] 208596000963 MgATP binding site [chemical binding]; other site 208596000964 catalytic site [active] 208596000965 metal binding site [ion binding]; metal-binding site 208596000966 putative carbohydrate binding site [chemical binding]; other site 208596000967 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 208596000968 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 208596000969 intersubunit interface [polypeptide binding]; other site 208596000970 active site 208596000971 Zn2+ binding site [ion binding]; other site 208596000972 L-arabinose isomerase; Provisional; Region: PRK02929 208596000973 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 208596000974 hexamer (dimer of trimers) interface [polypeptide binding]; other site 208596000975 trimer interface [polypeptide binding]; other site 208596000976 substrate binding site [chemical binding]; other site 208596000977 Mn binding site [ion binding]; other site 208596000978 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 208596000979 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208596000980 DNA-binding site [nucleotide binding]; DNA binding site 208596000981 Transcriptional regulators [Transcription]; Region: PurR; COG1609 208596000982 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 208596000983 putative dimerization interface [polypeptide binding]; other site 208596000984 putative ligand binding site [chemical binding]; other site 208596000985 sugar phosphate phosphatase; Provisional; Region: PRK10513 208596000986 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596000987 active site 208596000988 motif I; other site 208596000989 motif II; other site 208596000990 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596000991 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 208596000992 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208596000993 Zn2+ binding site [ion binding]; other site 208596000994 Mg2+ binding site [ion binding]; other site 208596000995 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 208596000996 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 208596000997 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 208596000998 CTP synthetase; Validated; Region: pyrG; PRK05380 208596000999 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 208596001000 Catalytic site [active] 208596001001 active site 208596001002 UTP binding site [chemical binding]; other site 208596001003 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 208596001004 active site 208596001005 putative oxyanion hole; other site 208596001006 catalytic triad [active] 208596001007 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 208596001008 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 208596001009 intersubunit interface [polypeptide binding]; other site 208596001010 active site 208596001011 zinc binding site [ion binding]; other site 208596001012 Na+ binding site [ion binding]; other site 208596001013 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 208596001014 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 208596001015 hinge; other site 208596001016 active site 208596001017 transcription termination factor Rho; Provisional; Region: rho; PRK09376 208596001018 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 208596001019 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 208596001020 RNA binding site [nucleotide binding]; other site 208596001021 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 208596001022 Walker A motif; other site 208596001023 ATP binding site [chemical binding]; other site 208596001024 Walker B motif; other site 208596001025 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 208596001026 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 208596001027 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 208596001028 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 208596001029 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 208596001030 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 208596001031 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 208596001032 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 208596001033 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 208596001034 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 208596001035 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 208596001036 DEAD-like helicases superfamily; Region: DEXDc; smart00487 208596001037 ATP binding site [chemical binding]; other site 208596001038 Mg++ binding site [ion binding]; other site 208596001039 motif III; other site 208596001040 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208596001041 nucleotide binding region [chemical binding]; other site 208596001042 ATP-binding site [chemical binding]; other site 208596001043 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 208596001044 PemK-like protein; Region: PemK; pfam02452 208596001045 QueT transporter; Region: QueT; pfam06177 208596001046 FOG: CBS domain [General function prediction only]; Region: COG0517 208596001047 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 208596001048 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 208596001049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208596001050 S-adenosylmethionine binding site [chemical binding]; other site 208596001051 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 208596001052 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 208596001053 putative NAD(P) binding site [chemical binding]; other site 208596001054 Predicted acetyltransferase [General function prediction only]; Region: COG2388 208596001055 Uncharacterized conserved protein [Function unknown]; Region: COG1624 208596001056 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 208596001057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 208596001058 YbbR-like protein; Region: YbbR; pfam07949 208596001059 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 208596001060 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 208596001061 active site 208596001062 substrate binding site [chemical binding]; other site 208596001063 metal binding site [ion binding]; metal-binding site 208596001064 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 208596001065 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 208596001066 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 208596001067 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 208596001068 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 208596001069 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 208596001070 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596001071 motif II; other site 208596001072 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 208596001073 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 208596001074 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 208596001075 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 208596001076 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 208596001077 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 208596001078 FtsX-like permease family; Region: FtsX; pfam02687 208596001079 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 208596001080 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 208596001081 Walker A/P-loop; other site 208596001082 ATP binding site [chemical binding]; other site 208596001083 Q-loop/lid; other site 208596001084 ABC transporter signature motif; other site 208596001085 Walker B; other site 208596001086 D-loop; other site 208596001087 H-loop/switch region; other site 208596001088 HlyD family secretion protein; Region: HlyD_3; pfam13437 208596001089 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 208596001090 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 208596001091 active site 208596001092 metal binding site [ion binding]; metal-binding site 208596001093 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 208596001094 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 208596001095 Walker A/P-loop; other site 208596001096 ATP binding site [chemical binding]; other site 208596001097 Q-loop/lid; other site 208596001098 ABC transporter signature motif; other site 208596001099 Walker B; other site 208596001100 D-loop; other site 208596001101 H-loop/switch region; other site 208596001102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596001103 dimer interface [polypeptide binding]; other site 208596001104 conserved gate region; other site 208596001105 ABC-ATPase subunit interface; other site 208596001106 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 208596001107 putative phosphoesterase; Region: acc_ester; TIGR03729 208596001108 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 208596001109 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 208596001110 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 208596001111 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 208596001112 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 208596001113 RNA binding site [nucleotide binding]; other site 208596001114 hypothetical protein; Provisional; Region: PRK04351 208596001115 SprT homologues; Region: SprT; cl01182 208596001116 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 208596001117 Pectate lyase; Region: Pec_lyase_C; cl01593 208596001118 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 208596001119 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 208596001120 active site 208596001121 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 208596001122 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 208596001123 homodimer interface [polypeptide binding]; other site 208596001124 NAD binding pocket [chemical binding]; other site 208596001125 ATP binding pocket [chemical binding]; other site 208596001126 Mg binding site [ion binding]; other site 208596001127 active-site loop [active] 208596001128 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 208596001129 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 208596001130 Ligand binding site; other site 208596001131 Putative Catalytic site; other site 208596001132 DXD motif; other site 208596001133 Sulfatase; Region: Sulfatase; pfam00884 208596001134 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 208596001135 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 208596001136 active site 208596001137 dimer interface [polypeptide binding]; other site 208596001138 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 208596001139 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 208596001140 active site 208596001141 trimer interface [polypeptide binding]; other site 208596001142 allosteric site; other site 208596001143 active site lid [active] 208596001144 hexamer (dimer of trimers) interface [polypeptide binding]; other site 208596001145 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 208596001146 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208596001147 DNA-binding site [nucleotide binding]; DNA binding site 208596001148 UTRA domain; Region: UTRA; pfam07702 208596001149 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 208596001150 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 208596001151 Mg++ binding site [ion binding]; other site 208596001152 putative catalytic motif [active] 208596001153 substrate binding site [chemical binding]; other site 208596001154 Transcriptional regulator [Transcription]; Region: LytR; COG1316 208596001155 Uncharacterized conserved protein [Function unknown]; Region: COG1739 208596001156 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 208596001157 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 208596001158 EDD domain protein, DegV family; Region: DegV; TIGR00762 208596001159 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 208596001160 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 208596001161 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208596001162 ATP binding site [chemical binding]; other site 208596001163 putative Mg++ binding site [ion binding]; other site 208596001164 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208596001165 nucleotide binding region [chemical binding]; other site 208596001166 ATP-binding site [chemical binding]; other site 208596001167 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 208596001168 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208596001169 active site 208596001170 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 208596001171 30S subunit binding site; other site 208596001172 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 208596001173 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 208596001174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208596001175 nucleotide binding region [chemical binding]; other site 208596001176 ATP-binding site [chemical binding]; other site 208596001177 SEC-C motif; Region: SEC-C; pfam02810 208596001178 peptide chain release factor 2; Validated; Region: prfB; PRK00578 208596001179 This domain is found in peptide chain release factors; Region: PCRF; smart00937 208596001180 RF-1 domain; Region: RF-1; pfam00472 208596001181 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 208596001182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596001183 Walker A/P-loop; other site 208596001184 ATP binding site [chemical binding]; other site 208596001185 Q-loop/lid; other site 208596001186 ABC transporter signature motif; other site 208596001187 Walker B; other site 208596001188 D-loop; other site 208596001189 H-loop/switch region; other site 208596001190 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 208596001191 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 208596001192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 208596001193 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 208596001194 NlpC/P60 family; Region: NLPC_P60; pfam00877 208596001195 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 208596001196 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 208596001197 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208596001198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208596001199 active site 208596001200 phosphorylation site [posttranslational modification] 208596001201 intermolecular recognition site; other site 208596001202 dimerization interface [polypeptide binding]; other site 208596001203 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208596001204 DNA binding site [nucleotide binding] 208596001205 HAMP domain; Region: HAMP; pfam00672 208596001206 dimerization interface [polypeptide binding]; other site 208596001207 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 208596001208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208596001209 dimer interface [polypeptide binding]; other site 208596001210 phosphorylation site [posttranslational modification] 208596001211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208596001212 ATP binding site [chemical binding]; other site 208596001213 Mg2+ binding site [ion binding]; other site 208596001214 G-X-G motif; other site 208596001215 PBP superfamily domain; Region: PBP_like_2; cl17296 208596001216 PBP superfamily domain; Region: PBP_like_2; cl17296 208596001217 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 208596001218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596001219 dimer interface [polypeptide binding]; other site 208596001220 conserved gate region; other site 208596001221 putative PBP binding loops; other site 208596001222 ABC-ATPase subunit interface; other site 208596001223 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 208596001224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596001225 dimer interface [polypeptide binding]; other site 208596001226 conserved gate region; other site 208596001227 putative PBP binding loops; other site 208596001228 ABC-ATPase subunit interface; other site 208596001229 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 208596001230 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 208596001231 Walker A/P-loop; other site 208596001232 ATP binding site [chemical binding]; other site 208596001233 Q-loop/lid; other site 208596001234 ABC transporter signature motif; other site 208596001235 Walker B; other site 208596001236 D-loop; other site 208596001237 H-loop/switch region; other site 208596001238 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 208596001239 PhoU domain; Region: PhoU; pfam01895 208596001240 PhoU domain; Region: PhoU; pfam01895 208596001241 phosphate binding protein; Region: ptsS_2; TIGR02136 208596001242 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 208596001243 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 208596001244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596001245 dimer interface [polypeptide binding]; other site 208596001246 conserved gate region; other site 208596001247 putative PBP binding loops; other site 208596001248 ABC-ATPase subunit interface; other site 208596001249 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 208596001250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596001251 dimer interface [polypeptide binding]; other site 208596001252 conserved gate region; other site 208596001253 putative PBP binding loops; other site 208596001254 ABC-ATPase subunit interface; other site 208596001255 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 208596001256 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 208596001257 Walker A/P-loop; other site 208596001258 ATP binding site [chemical binding]; other site 208596001259 Q-loop/lid; other site 208596001260 ABC transporter signature motif; other site 208596001261 Walker B; other site 208596001262 D-loop; other site 208596001263 H-loop/switch region; other site 208596001264 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 208596001265 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 208596001266 Walker A/P-loop; other site 208596001267 ATP binding site [chemical binding]; other site 208596001268 Q-loop/lid; other site 208596001269 ABC transporter signature motif; other site 208596001270 Walker B; other site 208596001271 D-loop; other site 208596001272 H-loop/switch region; other site 208596001273 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 208596001274 PhoU domain; Region: PhoU; pfam01895 208596001275 PhoU domain; Region: PhoU; pfam01895 208596001276 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208596001277 Zn2+ binding site [ion binding]; other site 208596001278 Mg2+ binding site [ion binding]; other site 208596001279 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 208596001280 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 208596001281 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 208596001282 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 208596001283 Uncharacterized conserved protein [Function unknown]; Region: COG3595 208596001284 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 208596001285 PspC domain; Region: PspC; pfam04024 208596001286 Predicted membrane protein [Function unknown]; Region: COG1950 208596001287 HPr kinase/phosphorylase; Provisional; Region: PRK05428 208596001288 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 208596001289 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 208596001290 Hpr binding site; other site 208596001291 active site 208596001292 homohexamer subunit interaction site [polypeptide binding]; other site 208596001293 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 208596001294 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 208596001295 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 208596001296 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 208596001297 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 208596001298 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 208596001299 active site 208596001300 tetramer interface; other site 208596001301 TPR repeat; Region: TPR_11; pfam13414 208596001302 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208596001303 binding surface 208596001304 TPR motif; other site 208596001305 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 208596001306 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 208596001307 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208596001308 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 208596001309 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 208596001310 active site 208596001311 substrate binding site [chemical binding]; other site 208596001312 metal binding site [ion binding]; metal-binding site 208596001313 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 208596001314 shikimate kinase; Reviewed; Region: aroK; PRK00131 208596001315 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 208596001316 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 208596001317 phosphate binding site [ion binding]; other site 208596001318 putative substrate binding pocket [chemical binding]; other site 208596001319 dimer interface [polypeptide binding]; other site 208596001320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 208596001321 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 208596001322 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 208596001323 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 208596001324 FMN binding site [chemical binding]; other site 208596001325 active site 208596001326 catalytic residues [active] 208596001327 substrate binding site [chemical binding]; other site 208596001328 Clp protease; Region: CLP_protease; pfam00574 208596001329 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 208596001330 oligomer interface [polypeptide binding]; other site 208596001331 active site residues [active] 208596001332 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 208596001333 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 208596001334 catalytic residues [active] 208596001335 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 208596001336 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 208596001337 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 208596001338 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 208596001339 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 208596001340 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 208596001341 Phosphoglycerate kinase; Region: PGK; pfam00162 208596001342 substrate binding site [chemical binding]; other site 208596001343 hinge regions; other site 208596001344 ADP binding site [chemical binding]; other site 208596001345 catalytic site [active] 208596001346 triosephosphate isomerase; Provisional; Region: PRK14567 208596001347 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 208596001348 substrate binding site [chemical binding]; other site 208596001349 dimer interface [polypeptide binding]; other site 208596001350 catalytic triad [active] 208596001351 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 208596001352 phosphoglyceromutase; Provisional; Region: PRK05434 208596001353 enolase; Provisional; Region: eno; PRK00077 208596001354 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 208596001355 dimer interface [polypeptide binding]; other site 208596001356 metal binding site [ion binding]; metal-binding site 208596001357 substrate binding pocket [chemical binding]; other site 208596001358 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 208596001359 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 208596001360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208596001361 Walker A motif; other site 208596001362 ATP binding site [chemical binding]; other site 208596001363 Walker B motif; other site 208596001364 arginine finger; other site 208596001365 Transcriptional antiterminator [Transcription]; Region: COG3933 208596001366 PRD domain; Region: PRD; pfam00874 208596001367 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 208596001368 active pocket/dimerization site; other site 208596001369 active site 208596001370 phosphorylation site [posttranslational modification] 208596001371 PRD domain; Region: PRD; pfam00874 208596001372 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 208596001373 active site 208596001374 phosphorylation site [posttranslational modification] 208596001375 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 208596001376 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208596001377 catalytic residue [active] 208596001378 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 208596001379 putative ligand binding site [chemical binding]; other site 208596001380 putative NAD binding site [chemical binding]; other site 208596001381 putative catalytic site [active] 208596001382 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 208596001383 L-serine binding site [chemical binding]; other site 208596001384 ACT domain interface; other site 208596001385 Uncharacterized conserved protein [Function unknown]; Region: COG4198 208596001386 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 208596001387 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 208596001388 Esterase/lipase [General function prediction only]; Region: COG1647 208596001389 ribonuclease R; Region: RNase_R; TIGR02063 208596001390 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 208596001391 RNB domain; Region: RNB; pfam00773 208596001392 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 208596001393 RNA binding site [nucleotide binding]; other site 208596001394 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 208596001395 SmpB-tmRNA interface; other site 208596001396 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 208596001397 catalytic residues [active] 208596001398 dimer interface [polypeptide binding]; other site 208596001399 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 208596001400 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 208596001401 catalytic core [active] 208596001402 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 208596001403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596001404 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 208596001405 active site 208596001406 motif I; other site 208596001407 motif II; other site 208596001408 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 208596001409 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 208596001410 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 208596001411 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 208596001412 heterotetramer interface [polypeptide binding]; other site 208596001413 active site pocket [active] 208596001414 cleavage site 208596001415 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 208596001416 nucleotide binding site [chemical binding]; other site 208596001417 N-acetyl-L-glutamate binding site [chemical binding]; other site 208596001418 acetylornithine aminotransferase; Provisional; Region: PRK02627 208596001419 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 208596001420 inhibitor-cofactor binding pocket; inhibition site 208596001421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208596001422 catalytic residue [active] 208596001423 ornithine carbamoyltransferase; Provisional; Region: PRK00779 208596001424 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 208596001425 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 208596001426 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 208596001427 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 208596001428 hexamer interface [polypeptide binding]; other site 208596001429 ligand binding site [chemical binding]; other site 208596001430 putative active site [active] 208596001431 NAD(P) binding site [chemical binding]; other site 208596001432 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 208596001433 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 208596001434 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 208596001435 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 208596001436 ArsC family; Region: ArsC; pfam03960 208596001437 putative ArsC-like catalytic residues; other site 208596001438 putative TRX-like catalytic residues [active] 208596001439 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 208596001440 lipoyl attachment site [posttranslational modification]; other site 208596001441 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 208596001442 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 208596001443 Walker A/P-loop; other site 208596001444 ATP binding site [chemical binding]; other site 208596001445 Q-loop/lid; other site 208596001446 ABC transporter signature motif; other site 208596001447 Walker B; other site 208596001448 D-loop; other site 208596001449 H-loop/switch region; other site 208596001450 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 208596001451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596001452 ABC-ATPase subunit interface; other site 208596001453 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 208596001454 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 208596001455 Transcriptional regulators [Transcription]; Region: PurR; COG1609 208596001456 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 208596001457 DNA binding site [nucleotide binding] 208596001458 domain linker motif; other site 208596001459 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 208596001460 putative dimerization interface [polypeptide binding]; other site 208596001461 putative ligand binding site [chemical binding]; other site 208596001462 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 208596001463 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 208596001464 NAD binding site [chemical binding]; other site 208596001465 sugar binding site [chemical binding]; other site 208596001466 divalent metal binding site [ion binding]; other site 208596001467 tetramer (dimer of dimers) interface [polypeptide binding]; other site 208596001468 dimer interface [polypeptide binding]; other site 208596001469 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 208596001470 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 208596001471 Bacterial PH domain; Region: DUF304; cl01348 208596001472 Predicted membrane protein [Function unknown]; Region: COG3428 208596001473 Bacterial PH domain; Region: DUF304; pfam03703 208596001474 Bacterial PH domain; Region: DUF304; cl01348 208596001475 Bacterial PH domain; Region: DUF304; pfam03703 208596001476 Bacterial PH domain; Region: DUF304; cl01348 208596001477 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 208596001478 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 208596001479 catalytic triad [active] 208596001480 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 208596001481 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 208596001482 Walker A/P-loop; other site 208596001483 ATP binding site [chemical binding]; other site 208596001484 Q-loop/lid; other site 208596001485 ABC transporter signature motif; other site 208596001486 Walker B; other site 208596001487 D-loop; other site 208596001488 H-loop/switch region; other site 208596001489 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 208596001490 FeS assembly protein SufD; Region: sufD; TIGR01981 208596001491 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 208596001492 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 208596001493 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208596001494 catalytic residue [active] 208596001495 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 208596001496 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 208596001497 trimerization site [polypeptide binding]; other site 208596001498 active site 208596001499 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 208596001500 FeS assembly protein SufB; Region: sufB; TIGR01980 208596001501 AAA domain; Region: AAA_21; pfam13304 208596001502 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 208596001503 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 208596001504 ATP binding site [chemical binding]; other site 208596001505 Mg++ binding site [ion binding]; other site 208596001506 motif III; other site 208596001507 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208596001508 nucleotide binding region [chemical binding]; other site 208596001509 ATP-binding site [chemical binding]; other site 208596001510 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 208596001511 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 208596001512 intersubunit interface [polypeptide binding]; other site 208596001513 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 208596001514 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 208596001515 ABC-ATPase subunit interface; other site 208596001516 dimer interface [polypeptide binding]; other site 208596001517 putative PBP binding regions; other site 208596001518 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 208596001519 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 208596001520 Walker A/P-loop; other site 208596001521 ATP binding site [chemical binding]; other site 208596001522 Q-loop/lid; other site 208596001523 ABC transporter signature motif; other site 208596001524 Walker B; other site 208596001525 D-loop; other site 208596001526 H-loop/switch region; other site 208596001527 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 208596001528 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 208596001529 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 208596001530 putative hydrophobic ligand binding site [chemical binding]; other site 208596001531 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208596001532 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208596001533 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 208596001534 Walker A/P-loop; other site 208596001535 ATP binding site [chemical binding]; other site 208596001536 Q-loop/lid; other site 208596001537 ABC transporter signature motif; other site 208596001538 Walker B; other site 208596001539 D-loop; other site 208596001540 H-loop/switch region; other site 208596001541 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208596001542 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208596001543 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596001544 Walker A/P-loop; other site 208596001545 ATP binding site [chemical binding]; other site 208596001546 Q-loop/lid; other site 208596001547 ABC transporter signature motif; other site 208596001548 Walker B; other site 208596001549 D-loop; other site 208596001550 H-loop/switch region; other site 208596001551 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 208596001552 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 208596001553 DNA binding residues [nucleotide binding] 208596001554 dimer interface [polypeptide binding]; other site 208596001555 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 208596001556 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 208596001557 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208596001558 substrate binding site [chemical binding]; other site 208596001559 oxyanion hole (OAH) forming residues; other site 208596001560 trimer interface [polypeptide binding]; other site 208596001561 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 208596001562 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 208596001563 catalytic motif [active] 208596001564 Zn binding site [ion binding]; other site 208596001565 RibD C-terminal domain; Region: RibD_C; cl17279 208596001566 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 208596001567 Lumazine binding domain; Region: Lum_binding; pfam00677 208596001568 Lumazine binding domain; Region: Lum_binding; pfam00677 208596001569 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 208596001570 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 208596001571 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 208596001572 dimerization interface [polypeptide binding]; other site 208596001573 active site 208596001574 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 208596001575 homopentamer interface [polypeptide binding]; other site 208596001576 active site 208596001577 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 208596001578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596001579 motif II; other site 208596001580 putative deaminase; Validated; Region: PRK06846 208596001581 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 208596001582 active site 208596001583 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 208596001584 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 208596001585 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 208596001586 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 208596001587 GIY-YIG motif/motif A; other site 208596001588 putative active site [active] 208596001589 putative metal binding site [ion binding]; other site 208596001590 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 208596001591 putative active site [active] 208596001592 RDD family; Region: RDD; cl00746 208596001593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 208596001594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208596001595 S-adenosylmethionine binding site [chemical binding]; other site 208596001596 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208596001597 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208596001598 substrate binding pocket [chemical binding]; other site 208596001599 membrane-bound complex binding site; other site 208596001600 hinge residues; other site 208596001601 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 208596001602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596001603 dimer interface [polypeptide binding]; other site 208596001604 conserved gate region; other site 208596001605 putative PBP binding loops; other site 208596001606 ABC-ATPase subunit interface; other site 208596001607 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 208596001608 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 208596001609 Walker A/P-loop; other site 208596001610 ATP binding site [chemical binding]; other site 208596001611 Q-loop/lid; other site 208596001612 ABC transporter signature motif; other site 208596001613 Walker B; other site 208596001614 D-loop; other site 208596001615 H-loop/switch region; other site 208596001616 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 208596001617 Nucleoside Triphosphate Pyrophosphohydrolase EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u6; cd11543 208596001618 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 208596001619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596001620 Walker A/P-loop; other site 208596001621 ATP binding site [chemical binding]; other site 208596001622 Q-loop/lid; other site 208596001623 ABC transporter signature motif; other site 208596001624 Walker B; other site 208596001625 D-loop; other site 208596001626 H-loop/switch region; other site 208596001627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596001628 dimer interface [polypeptide binding]; other site 208596001629 conserved gate region; other site 208596001630 putative PBP binding loops; other site 208596001631 ABC-ATPase subunit interface; other site 208596001632 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 208596001633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596001634 dimer interface [polypeptide binding]; other site 208596001635 conserved gate region; other site 208596001636 putative PBP binding loops; other site 208596001637 ABC-ATPase subunit interface; other site 208596001638 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 208596001639 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 208596001640 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 208596001641 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 208596001642 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 208596001643 magnesium-transporting ATPase; Provisional; Region: PRK15122 208596001644 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 208596001645 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 208596001646 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 208596001647 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 208596001648 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 208596001649 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 208596001650 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 208596001651 peptide binding site [polypeptide binding]; other site 208596001652 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 208596001653 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 208596001654 putative active site [active] 208596001655 putative metal binding site [ion binding]; other site 208596001656 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 208596001657 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 208596001658 Walker A/P-loop; other site 208596001659 ATP binding site [chemical binding]; other site 208596001660 Q-loop/lid; other site 208596001661 ABC transporter signature motif; other site 208596001662 Walker B; other site 208596001663 D-loop; other site 208596001664 H-loop/switch region; other site 208596001665 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 208596001666 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 208596001667 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 208596001668 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208596001669 DNA-binding site [nucleotide binding]; DNA binding site 208596001670 UTRA domain; Region: UTRA; pfam07702 208596001671 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 208596001672 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 208596001673 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 208596001674 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 208596001675 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 208596001676 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 208596001677 Walker A/P-loop; other site 208596001678 ATP binding site [chemical binding]; other site 208596001679 Q-loop/lid; other site 208596001680 ABC transporter signature motif; other site 208596001681 Walker B; other site 208596001682 D-loop; other site 208596001683 H-loop/switch region; other site 208596001684 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 208596001685 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 208596001686 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 208596001687 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 208596001688 active site 208596001689 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 208596001690 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 208596001691 trimer interface [polypeptide binding]; other site 208596001692 active site 208596001693 substrate binding site [chemical binding]; other site 208596001694 CoA binding site [chemical binding]; other site 208596001695 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 208596001696 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596001697 Walker A/P-loop; other site 208596001698 ATP binding site [chemical binding]; other site 208596001699 Q-loop/lid; other site 208596001700 ABC transporter signature motif; other site 208596001701 Walker B; other site 208596001702 D-loop; other site 208596001703 H-loop/switch region; other site 208596001704 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 208596001705 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 208596001706 active site 208596001707 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 208596001708 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 208596001709 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 208596001710 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 208596001711 Walker A/P-loop; other site 208596001712 ATP binding site [chemical binding]; other site 208596001713 Q-loop/lid; other site 208596001714 ABC transporter signature motif; other site 208596001715 Walker B; other site 208596001716 D-loop; other site 208596001717 H-loop/switch region; other site 208596001718 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 208596001719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596001720 dimer interface [polypeptide binding]; other site 208596001721 conserved gate region; other site 208596001722 putative PBP binding loops; other site 208596001723 ABC-ATPase subunit interface; other site 208596001724 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 208596001725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596001726 dimer interface [polypeptide binding]; other site 208596001727 conserved gate region; other site 208596001728 ABC-ATPase subunit interface; other site 208596001729 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 208596001730 catalytic residues [active] 208596001731 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 208596001732 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 208596001733 peptide binding site [polypeptide binding]; other site 208596001734 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 208596001735 ATP binding site [chemical binding]; other site 208596001736 substrate binding site [chemical binding]; other site 208596001737 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 208596001738 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 208596001739 active pocket/dimerization site; other site 208596001740 active site 208596001741 phosphorylation site [posttranslational modification] 208596001742 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 208596001743 active site 208596001744 phosphorylation site [posttranslational modification] 208596001745 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 208596001746 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 208596001747 Domain of unknown function (DUF956); Region: DUF956; pfam06115 208596001748 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 208596001749 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 208596001750 conserved cys residue [active] 208596001751 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 208596001752 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 208596001753 Walker A/P-loop; other site 208596001754 ATP binding site [chemical binding]; other site 208596001755 Q-loop/lid; other site 208596001756 ABC transporter signature motif; other site 208596001757 Walker B; other site 208596001758 D-loop; other site 208596001759 H-loop/switch region; other site 208596001760 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 208596001761 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 208596001762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 208596001763 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208596001764 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 208596001765 active site 208596001766 catalytic tetrad [active] 208596001767 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 208596001768 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 208596001769 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 208596001770 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596001771 Coenzyme A binding pocket [chemical binding]; other site 208596001772 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 208596001773 DNA binding site [nucleotide binding] 208596001774 active site 208596001775 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 208596001776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596001777 dimer interface [polypeptide binding]; other site 208596001778 conserved gate region; other site 208596001779 putative PBP binding loops; other site 208596001780 ABC-ATPase subunit interface; other site 208596001781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596001782 dimer interface [polypeptide binding]; other site 208596001783 conserved gate region; other site 208596001784 putative PBP binding loops; other site 208596001785 ABC-ATPase subunit interface; other site 208596001786 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208596001787 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208596001788 substrate binding pocket [chemical binding]; other site 208596001789 membrane-bound complex binding site; other site 208596001790 hinge residues; other site 208596001791 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 208596001792 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 208596001793 Walker A/P-loop; other site 208596001794 ATP binding site [chemical binding]; other site 208596001795 Q-loop/lid; other site 208596001796 ABC transporter signature motif; other site 208596001797 Walker B; other site 208596001798 D-loop; other site 208596001799 H-loop/switch region; other site 208596001800 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 208596001801 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 208596001802 active site 208596001803 metal binding site [ion binding]; metal-binding site 208596001804 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 208596001805 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 208596001806 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 208596001807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596001808 active site 208596001809 motif I; other site 208596001810 motif II; other site 208596001811 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596001812 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 208596001813 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 208596001814 tetramer interfaces [polypeptide binding]; other site 208596001815 binuclear metal-binding site [ion binding]; other site 208596001816 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 208596001817 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 208596001818 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208596001819 Divergent PAP2 family; Region: DUF212; pfam02681 208596001820 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 208596001821 active site 208596001822 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 208596001823 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208596001824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208596001825 homodimer interface [polypeptide binding]; other site 208596001826 catalytic residue [active] 208596001827 general stress protein 13; Validated; Region: PRK08059 208596001828 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 208596001829 RNA binding site [nucleotide binding]; other site 208596001830 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 208596001831 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 208596001832 active site 208596001833 dimer interface [polypeptide binding]; other site 208596001834 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 208596001835 dimer interface [polypeptide binding]; other site 208596001836 active site 208596001837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 208596001838 S-adenosylmethionine synthetase; Validated; Region: PRK05250 208596001839 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 208596001840 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 208596001841 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 208596001842 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 208596001843 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 208596001844 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 208596001845 active site 208596001846 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596001847 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 208596001848 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596001849 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596001850 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596001851 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596001852 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596001853 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596001854 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596001855 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596001856 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596001857 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 208596001858 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596001859 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 208596001860 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596001861 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 208596001862 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 208596001863 HIGH motif; other site 208596001864 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 208596001865 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 208596001866 active site 208596001867 KMSKS motif; other site 208596001868 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 208596001869 tRNA binding surface [nucleotide binding]; other site 208596001870 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 208596001871 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 208596001872 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 208596001873 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 208596001874 RNA binding surface [nucleotide binding]; other site 208596001875 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 208596001876 active site 208596001877 uracil binding [chemical binding]; other site 208596001878 Heat induced stress protein YflT; Region: YflT; pfam11181 208596001879 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 208596001880 putative substrate binding site [chemical binding]; other site 208596001881 putative ATP binding site [chemical binding]; other site 208596001882 dipeptidase PepV; Reviewed; Region: PRK07318 208596001883 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 208596001884 active site 208596001885 metal binding site [ion binding]; metal-binding site 208596001886 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 208596001887 aspartate racemase; Region: asp_race; TIGR00035 208596001888 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 208596001889 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 208596001890 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 208596001891 putative NAD(P) binding site [chemical binding]; other site 208596001892 putative active site [active] 208596001893 putative glycosyl transferase; Provisional; Region: PRK10073 208596001894 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 208596001895 active site 208596001896 Protein of unknown function (DUF975); Region: DUF975; cl10504 208596001897 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 208596001898 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 208596001899 putative Cl- selectivity filter; other site 208596001900 putative pore gating glutamate residue; other site 208596001901 Thioredoxin; Region: Thioredoxin_5; pfam13743 208596001902 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 208596001903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596001904 Coenzyme A binding pocket [chemical binding]; other site 208596001905 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 208596001906 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 208596001907 dimer interface [polypeptide binding]; other site 208596001908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208596001909 catalytic residue [active] 208596001910 cystathionine beta-lyase; Provisional; Region: PRK07671 208596001911 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 208596001912 homodimer interface [polypeptide binding]; other site 208596001913 substrate-cofactor binding pocket; other site 208596001914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208596001915 catalytic residue [active] 208596001916 Methyltransferase domain; Region: Methyltransf_23; pfam13489 208596001917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208596001918 S-adenosylmethionine binding site [chemical binding]; other site 208596001919 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 208596001920 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 208596001921 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 208596001922 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 208596001923 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 208596001924 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 208596001925 Tubby C 2; Region: Tub_2; cl02043 208596001926 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 208596001927 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208596001928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208596001929 putative substrate translocation pore; other site 208596001930 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208596001931 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 208596001932 active site 208596001933 catalytic tetrad [active] 208596001934 Predicted membrane protein [Function unknown]; Region: COG2035 208596001935 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 208596001936 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 208596001937 dimer interface [polypeptide binding]; other site 208596001938 pyridoxal binding site [chemical binding]; other site 208596001939 ATP binding site [chemical binding]; other site 208596001940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208596001941 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208596001942 putative substrate translocation pore; other site 208596001943 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 208596001944 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 208596001945 putative NAD(P) binding site [chemical binding]; other site 208596001946 Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304 208596001947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 208596001948 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 208596001949 Peptidase family M23; Region: Peptidase_M23; pfam01551 208596001950 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 208596001951 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 208596001952 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 208596001953 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208596001954 Zn2+ binding site [ion binding]; other site 208596001955 Mg2+ binding site [ion binding]; other site 208596001956 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 208596001957 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 208596001958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596001959 Coenzyme A binding pocket [chemical binding]; other site 208596001960 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 208596001961 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 208596001962 teramer interface [polypeptide binding]; other site 208596001963 active site 208596001964 FMN binding site [chemical binding]; other site 208596001965 catalytic residues [active] 208596001966 Predicted transcriptional regulators [Transcription]; Region: COG1733 208596001967 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208596001968 dimerization interface [polypeptide binding]; other site 208596001969 putative DNA binding site [nucleotide binding]; other site 208596001970 putative Zn2+ binding site [ion binding]; other site 208596001971 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 208596001972 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 208596001973 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 208596001974 dimer interface [polypeptide binding]; other site 208596001975 motif 1; other site 208596001976 active site 208596001977 motif 2; other site 208596001978 motif 3; other site 208596001979 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 208596001980 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 208596001981 putative tRNA-binding site [nucleotide binding]; other site 208596001982 B3/4 domain; Region: B3_4; pfam03483 208596001983 tRNA synthetase B5 domain; Region: B5; smart00874 208596001984 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 208596001985 dimer interface [polypeptide binding]; other site 208596001986 motif 1; other site 208596001987 motif 3; other site 208596001988 motif 2; other site 208596001989 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 208596001990 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 208596001991 ribonuclease HIII; Provisional; Region: PRK00996 208596001992 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 208596001993 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 208596001994 RNA/DNA hybrid binding site [nucleotide binding]; other site 208596001995 active site 208596001996 Cell division protein ZapA; Region: ZapA; pfam05164 208596001997 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 208596001998 Colicin V production protein; Region: Colicin_V; pfam02674 208596001999 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 208596002000 MutS domain III; Region: MutS_III; pfam05192 208596002001 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 208596002002 Walker A/P-loop; other site 208596002003 ATP binding site [chemical binding]; other site 208596002004 Q-loop/lid; other site 208596002005 ABC transporter signature motif; other site 208596002006 Walker B; other site 208596002007 D-loop; other site 208596002008 H-loop/switch region; other site 208596002009 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 208596002010 Smr domain; Region: Smr; pfam01713 208596002011 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 208596002012 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 208596002013 catalytic residues [active] 208596002014 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596002015 non-specific DNA binding site [nucleotide binding]; other site 208596002016 salt bridge; other site 208596002017 sequence-specific DNA binding site [nucleotide binding]; other site 208596002018 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 208596002019 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 208596002020 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 208596002021 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 208596002022 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 208596002023 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 208596002024 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 208596002025 Heat induced stress protein YflT; Region: YflT; pfam11181 208596002026 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 208596002027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596002028 Walker A/P-loop; other site 208596002029 ATP binding site [chemical binding]; other site 208596002030 Q-loop/lid; other site 208596002031 ABC transporter signature motif; other site 208596002032 Walker B; other site 208596002033 D-loop; other site 208596002034 H-loop/switch region; other site 208596002035 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 208596002036 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 208596002037 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 208596002038 glutamate racemase; Provisional; Region: PRK00865 208596002039 ribonuclease PH; Reviewed; Region: rph; PRK00173 208596002040 Ribonuclease PH; Region: RNase_PH_bact; cd11362 208596002041 hexamer interface [polypeptide binding]; other site 208596002042 active site 208596002043 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 208596002044 active site 208596002045 dimerization interface [polypeptide binding]; other site 208596002046 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 208596002047 active site 208596002048 metal binding site [ion binding]; metal-binding site 208596002049 homotetramer interface [polypeptide binding]; other site 208596002050 FOG: CBS domain [General function prediction only]; Region: COG0517 208596002051 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 208596002052 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 208596002053 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 208596002054 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 208596002055 trimer interface [polypeptide binding]; other site 208596002056 active site 208596002057 substrate binding site [chemical binding]; other site 208596002058 CoA binding site [chemical binding]; other site 208596002059 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 208596002060 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 208596002061 metal binding site [ion binding]; metal-binding site 208596002062 putative dimer interface [polypeptide binding]; other site 208596002063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208596002064 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208596002065 putative substrate translocation pore; other site 208596002066 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 208596002067 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 208596002068 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 208596002069 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 208596002070 Mechanosensitive ion channel; Region: MS_channel; pfam00924 208596002071 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 208596002072 YtxH-like protein; Region: YtxH; pfam12732 208596002073 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 208596002074 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 208596002075 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 208596002076 active site 208596002077 catabolite control protein A; Region: ccpA; TIGR01481 208596002078 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 208596002079 DNA binding site [nucleotide binding] 208596002080 domain linker motif; other site 208596002081 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 208596002082 dimerization interface [polypeptide binding]; other site 208596002083 effector binding site; other site 208596002084 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 208596002085 Transglycosylase; Region: Transgly; pfam00912 208596002086 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 208596002087 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 208596002088 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 208596002089 zinc binding site [ion binding]; other site 208596002090 putative ligand binding site [chemical binding]; other site 208596002091 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 208596002092 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 208596002093 TM-ABC transporter signature motif; other site 208596002094 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 208596002095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596002096 Walker A/P-loop; other site 208596002097 ATP binding site [chemical binding]; other site 208596002098 Q-loop/lid; other site 208596002099 ABC transporter signature motif; other site 208596002100 Walker B; other site 208596002101 D-loop; other site 208596002102 H-loop/switch region; other site 208596002103 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 208596002104 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 208596002105 active site residue [active] 208596002106 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 208596002107 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 208596002108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 208596002109 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 208596002110 NlpC/P60 family; Region: NLPC_P60; pfam00877 208596002111 putative lipid kinase; Reviewed; Region: PRK13337 208596002112 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 208596002113 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 208596002114 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 208596002115 active site 208596002116 Zn binding site [ion binding]; other site 208596002117 Predicted integral membrane protein [Function unknown]; Region: COG5652 208596002118 hypothetical protein; Validated; Region: PRK00110 208596002119 Type II/IV secretion system protein; Region: T2SE; pfam00437 208596002120 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 208596002121 Walker A motif; other site 208596002122 ATP binding site [chemical binding]; other site 208596002123 Walker B motif; other site 208596002124 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 208596002125 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 208596002126 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 208596002127 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 208596002128 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 208596002129 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 208596002130 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 208596002131 ComG operon protein 7; Region: ComGG; pfam14173 208596002132 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 208596002133 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 208596002134 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 208596002135 active site 208596002136 elongation factor P; Validated; Region: PRK00529 208596002137 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 208596002138 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 208596002139 RNA binding site [nucleotide binding]; other site 208596002140 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 208596002141 RNA binding site [nucleotide binding]; other site 208596002142 Asp23 family; Region: Asp23; pfam03780 208596002143 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 208596002144 putative RNA binding site [nucleotide binding]; other site 208596002145 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 208596002146 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 208596002147 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 208596002148 homodimer interface [polypeptide binding]; other site 208596002149 NADP binding site [chemical binding]; other site 208596002150 substrate binding site [chemical binding]; other site 208596002151 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 208596002152 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 208596002153 generic binding surface II; other site 208596002154 generic binding surface I; other site 208596002155 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 208596002156 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 208596002157 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 208596002158 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 208596002159 substrate binding pocket [chemical binding]; other site 208596002160 chain length determination region; other site 208596002161 substrate-Mg2+ binding site; other site 208596002162 catalytic residues [active] 208596002163 aspartate-rich region 1; other site 208596002164 active site lid residues [active] 208596002165 aspartate-rich region 2; other site 208596002166 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 208596002167 S4 RNA-binding domain; Region: S4; smart00363 208596002168 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 208596002169 Arginine repressor [Transcription]; Region: ArgR; COG1438 208596002170 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 208596002171 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 208596002172 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 208596002173 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 208596002174 Walker A/P-loop; other site 208596002175 ATP binding site [chemical binding]; other site 208596002176 Q-loop/lid; other site 208596002177 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 208596002178 ABC transporter signature motif; other site 208596002179 Walker B; other site 208596002180 D-loop; other site 208596002181 H-loop/switch region; other site 208596002182 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 208596002183 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 208596002184 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 208596002185 Cl binding site [ion binding]; other site 208596002186 oligomer interface [polypeptide binding]; other site 208596002187 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 208596002188 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 208596002189 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 208596002190 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208596002191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208596002192 active site 208596002193 phosphorylation site [posttranslational modification] 208596002194 intermolecular recognition site; other site 208596002195 dimerization interface [polypeptide binding]; other site 208596002196 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208596002197 DNA binding site [nucleotide binding] 208596002198 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208596002199 HAMP domain; Region: HAMP; pfam00672 208596002200 dimerization interface [polypeptide binding]; other site 208596002201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208596002202 dimer interface [polypeptide binding]; other site 208596002203 phosphorylation site [posttranslational modification] 208596002204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208596002205 ATP binding site [chemical binding]; other site 208596002206 Mg2+ binding site [ion binding]; other site 208596002207 G-X-G motif; other site 208596002208 OxaA-like protein precursor; Provisional; Region: PRK02463 208596002209 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 208596002210 Acylphosphatase; Region: Acylphosphatase; pfam00708 208596002211 DNA topoisomerase III; Provisional; Region: PRK07726 208596002212 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 208596002213 active site 208596002214 putative interdomain interaction site [polypeptide binding]; other site 208596002215 putative metal-binding site [ion binding]; other site 208596002216 putative nucleotide binding site [chemical binding]; other site 208596002217 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 208596002218 domain I; other site 208596002219 DNA binding groove [nucleotide binding] 208596002220 phosphate binding site [ion binding]; other site 208596002221 domain II; other site 208596002222 domain III; other site 208596002223 nucleotide binding site [chemical binding]; other site 208596002224 catalytic site [active] 208596002225 domain IV; other site 208596002226 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 208596002227 Merozoite surface protein (SPAM); Region: Merozoite_SPAM; pfam07133 208596002228 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 208596002229 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 208596002230 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 208596002231 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 208596002232 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 208596002233 ligand binding site [chemical binding]; other site 208596002234 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 208596002235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596002236 Walker A/P-loop; other site 208596002237 ATP binding site [chemical binding]; other site 208596002238 Q-loop/lid; other site 208596002239 ABC transporter signature motif; other site 208596002240 Walker B; other site 208596002241 D-loop; other site 208596002242 H-loop/switch region; other site 208596002243 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 208596002244 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 208596002245 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 208596002246 TM-ABC transporter signature motif; other site 208596002247 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 208596002248 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 208596002249 TM-ABC transporter signature motif; other site 208596002250 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 208596002251 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 208596002252 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 208596002253 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 208596002254 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 208596002255 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 208596002256 classical (c) SDRs; Region: SDR_c; cd05233 208596002257 NAD(P) binding site [chemical binding]; other site 208596002258 active site 208596002259 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 208596002260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596002261 non-specific DNA binding site [nucleotide binding]; other site 208596002262 salt bridge; other site 208596002263 sequence-specific DNA binding site [nucleotide binding]; other site 208596002264 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 208596002265 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 208596002266 competence damage-inducible protein A; Provisional; Region: PRK00549 208596002267 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 208596002268 putative MPT binding site; other site 208596002269 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 208596002270 recombinase A; Provisional; Region: recA; PRK09354 208596002271 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 208596002272 hexamer interface [polypeptide binding]; other site 208596002273 Walker A motif; other site 208596002274 ATP binding site [chemical binding]; other site 208596002275 Walker B motif; other site 208596002276 phosphodiesterase; Provisional; Region: PRK12704 208596002277 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 208596002278 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208596002279 Zn2+ binding site [ion binding]; other site 208596002280 Mg2+ binding site [ion binding]; other site 208596002281 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 208596002282 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 208596002283 putative active site [active] 208596002284 metal binding site [ion binding]; metal-binding site 208596002285 homodimer binding site [polypeptide binding]; other site 208596002286 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 208596002287 MutS domain I; Region: MutS_I; pfam01624 208596002288 MutS domain II; Region: MutS_II; pfam05188 208596002289 MutS domain III; Region: MutS_III; pfam05192 208596002290 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 208596002291 Walker A/P-loop; other site 208596002292 ATP binding site [chemical binding]; other site 208596002293 Q-loop/lid; other site 208596002294 ABC transporter signature motif; other site 208596002295 Walker B; other site 208596002296 D-loop; other site 208596002297 H-loop/switch region; other site 208596002298 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 208596002299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208596002300 ATP binding site [chemical binding]; other site 208596002301 Mg2+ binding site [ion binding]; other site 208596002302 G-X-G motif; other site 208596002303 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 208596002304 ATP binding site [chemical binding]; other site 208596002305 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 208596002306 methionine sulfoxide reductase B; Provisional; Region: PRK00222 208596002307 SelR domain; Region: SelR; pfam01641 208596002308 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 208596002309 RuvA N terminal domain; Region: RuvA_N; pfam01330 208596002310 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 208596002311 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 208596002312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208596002313 Walker A motif; other site 208596002314 ATP binding site [chemical binding]; other site 208596002315 Walker B motif; other site 208596002316 arginine finger; other site 208596002317 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 208596002318 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 208596002319 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 208596002320 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208596002321 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208596002322 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 208596002323 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 208596002324 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 208596002325 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 208596002326 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 208596002327 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 208596002328 putative catalytic cysteine [active] 208596002329 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 208596002330 putative active site [active] 208596002331 metal binding site [ion binding]; metal-binding site 208596002332 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 208596002333 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 208596002334 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 208596002335 FeoA domain; Region: FeoA; pfam04023 208596002336 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 208596002337 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 208596002338 intersubunit interface [polypeptide binding]; other site 208596002339 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 208596002340 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 208596002341 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 208596002342 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 208596002343 ABC-ATPase subunit interface; other site 208596002344 dimer interface [polypeptide binding]; other site 208596002345 putative PBP binding regions; other site 208596002346 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 208596002347 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 208596002348 ABC-ATPase subunit interface; other site 208596002349 dimer interface [polypeptide binding]; other site 208596002350 putative PBP binding regions; other site 208596002351 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 208596002352 active site 208596002353 DNA polymerase IV; Validated; Region: PRK02406 208596002354 DNA binding site [nucleotide binding] 208596002355 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 208596002356 metal-dependent hydrolase; Provisional; Region: PRK00685 208596002357 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 208596002358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208596002359 DNA-binding site [nucleotide binding]; DNA binding site 208596002360 DRTGG domain; Region: DRTGG; pfam07085 208596002361 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 208596002362 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 208596002363 active site 2 [active] 208596002364 active site 1 [active] 208596002365 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 208596002366 DHH family; Region: DHH; pfam01368 208596002367 DHHA1 domain; Region: DHHA1; pfam02272 208596002368 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 208596002369 Domain of unknown function DUF21; Region: DUF21; pfam01595 208596002370 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 208596002371 Transporter associated domain; Region: CorC_HlyC; smart01091 208596002372 Transglycosylase; Region: Transgly; pfam00912 208596002373 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 208596002374 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 208596002375 hypothetical protein; Provisional; Region: PRK13676 208596002376 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 208596002377 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 208596002378 active site 208596002379 metal binding site [ion binding]; metal-binding site 208596002380 DNA binding site [nucleotide binding] 208596002381 Uncharacterized conserved protein [Function unknown]; Region: COG4717 208596002382 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 208596002383 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 208596002384 generic binding surface I; other site 208596002385 generic binding surface II; other site 208596002386 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208596002387 Zn2+ binding site [ion binding]; other site 208596002388 Mg2+ binding site [ion binding]; other site 208596002389 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 208596002390 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 208596002391 YtxH-like protein; Region: YtxH; cl02079 208596002392 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 208596002393 HIT family signature motif; other site 208596002394 catalytic residue [active] 208596002395 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 208596002396 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 208596002397 Walker A/P-loop; other site 208596002398 ATP binding site [chemical binding]; other site 208596002399 Q-loop/lid; other site 208596002400 ABC transporter signature motif; other site 208596002401 Walker B; other site 208596002402 D-loop; other site 208596002403 H-loop/switch region; other site 208596002404 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 208596002405 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 208596002406 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 208596002407 homodimer interface [polypeptide binding]; other site 208596002408 substrate-cofactor binding pocket; other site 208596002409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208596002410 catalytic residue [active] 208596002411 Phosphotransferase enzyme family; Region: APH; pfam01636 208596002412 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 208596002413 active site 208596002414 ATP binding site [chemical binding]; other site 208596002415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208596002416 S-adenosylmethionine binding site [chemical binding]; other site 208596002417 Predicted small secreted protein [Function unknown]; Region: COG5584 208596002418 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 208596002419 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 208596002420 oligomer interface [polypeptide binding]; other site 208596002421 active site 208596002422 metal binding site [ion binding]; metal-binding site 208596002423 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 208596002424 catalytic residues [active] 208596002425 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 208596002426 Ligand Binding Site [chemical binding]; other site 208596002427 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 208596002428 putative tRNA-binding site [nucleotide binding]; other site 208596002429 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 208596002430 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 208596002431 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 208596002432 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 208596002433 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 208596002434 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 208596002435 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 208596002436 DNA polymerase I; Provisional; Region: PRK05755 208596002437 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 208596002438 active site 208596002439 metal binding site 1 [ion binding]; metal-binding site 208596002440 putative 5' ssDNA interaction site; other site 208596002441 metal binding site 3; metal-binding site 208596002442 metal binding site 2 [ion binding]; metal-binding site 208596002443 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 208596002444 putative DNA binding site [nucleotide binding]; other site 208596002445 putative metal binding site [ion binding]; other site 208596002446 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 208596002447 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 208596002448 active site 208596002449 DNA binding site [nucleotide binding] 208596002450 catalytic site [active] 208596002451 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 208596002452 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 208596002453 DNA binding site [nucleotide binding] 208596002454 catalytic residue [active] 208596002455 H2TH interface [polypeptide binding]; other site 208596002456 putative catalytic residues [active] 208596002457 turnover-facilitating residue; other site 208596002458 intercalation triad [nucleotide binding]; other site 208596002459 8OG recognition residue [nucleotide binding]; other site 208596002460 putative reading head residues; other site 208596002461 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 208596002462 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 208596002463 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 208596002464 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 208596002465 CoA-binding site [chemical binding]; other site 208596002466 ATP-binding [chemical binding]; other site 208596002467 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 208596002468 ATP cone domain; Region: ATP-cone; pfam03477 208596002469 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 208596002470 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 208596002471 primosomal protein DnaI; Reviewed; Region: PRK08939 208596002472 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 208596002473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208596002474 Walker A motif; other site 208596002475 ATP binding site [chemical binding]; other site 208596002476 Walker B motif; other site 208596002477 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 208596002478 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 208596002479 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 208596002480 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 208596002481 active site 208596002482 dimer interface [polypeptide binding]; other site 208596002483 motif 1; other site 208596002484 motif 2; other site 208596002485 motif 3; other site 208596002486 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 208596002487 anticodon binding site; other site 208596002488 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 208596002489 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 208596002490 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 208596002491 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 208596002492 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 208596002493 23S rRNA binding site [nucleotide binding]; other site 208596002494 L21 binding site [polypeptide binding]; other site 208596002495 L13 binding site [polypeptide binding]; other site 208596002496 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 208596002497 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 208596002498 peptide binding site [polypeptide binding]; other site 208596002499 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 208596002500 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 208596002501 peptide binding site [polypeptide binding]; other site 208596002502 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 208596002503 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 208596002504 oligomer interface [polypeptide binding]; other site 208596002505 active site 208596002506 metal binding site [ion binding]; metal-binding site 208596002507 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 208596002508 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 208596002509 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 208596002510 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 208596002511 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 208596002512 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 208596002513 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 208596002514 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 208596002515 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 208596002516 active site 208596002517 HIGH motif; other site 208596002518 dimer interface [polypeptide binding]; other site 208596002519 KMSKS motif; other site 208596002520 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 208596002521 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 208596002522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596002523 dimer interface [polypeptide binding]; other site 208596002524 conserved gate region; other site 208596002525 putative PBP binding loops; other site 208596002526 ABC-ATPase subunit interface; other site 208596002527 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 208596002528 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 208596002529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596002530 dimer interface [polypeptide binding]; other site 208596002531 conserved gate region; other site 208596002532 putative PBP binding loops; other site 208596002533 ABC-ATPase subunit interface; other site 208596002534 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 208596002535 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 208596002536 Walker A/P-loop; other site 208596002537 ATP binding site [chemical binding]; other site 208596002538 Q-loop/lid; other site 208596002539 ABC transporter signature motif; other site 208596002540 Walker B; other site 208596002541 D-loop; other site 208596002542 H-loop/switch region; other site 208596002543 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 208596002544 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 208596002545 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 208596002546 Walker A/P-loop; other site 208596002547 ATP binding site [chemical binding]; other site 208596002548 Q-loop/lid; other site 208596002549 ABC transporter signature motif; other site 208596002550 Walker B; other site 208596002551 D-loop; other site 208596002552 H-loop/switch region; other site 208596002553 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 208596002554 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 208596002555 ArsC family; Region: ArsC; pfam03960 208596002556 putative catalytic residues [active] 208596002557 thiol/disulfide switch; other site 208596002558 adaptor protein; Provisional; Region: PRK02315 208596002559 Competence protein CoiA-like family; Region: CoiA; cl11541 208596002560 oligoendopeptidase F; Region: pepF; TIGR00181 208596002561 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 208596002562 active site 208596002563 Zn binding site [ion binding]; other site 208596002564 Thioredoxin; Region: Thioredoxin_5; pfam13743 208596002565 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 208596002566 putative active site [active] 208596002567 putative metal binding residues [ion binding]; other site 208596002568 signature motif; other site 208596002569 putative triphosphate binding site [ion binding]; other site 208596002570 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 208596002571 synthetase active site [active] 208596002572 NTP binding site [chemical binding]; other site 208596002573 metal binding site [ion binding]; metal-binding site 208596002574 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 208596002575 ATP-NAD kinase; Region: NAD_kinase; pfam01513 208596002576 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 208596002577 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 208596002578 active site 208596002579 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 208596002580 MgtE intracellular N domain; Region: MgtE_N; pfam03448 208596002581 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 208596002582 Divalent cation transporter; Region: MgtE; pfam01769 208596002583 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 208596002584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596002585 Coenzyme A binding pocket [chemical binding]; other site 208596002586 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 208596002587 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 208596002588 putative oligomer interface [polypeptide binding]; other site 208596002589 putative active site [active] 208596002590 metal binding site [ion binding]; metal-binding site 208596002591 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 208596002592 Domain of unknown function DUF20; Region: UPF0118; pfam01594 208596002593 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 208596002594 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208596002595 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 208596002596 Staphylococcal nuclease homologues; Region: SNc; smart00318 208596002597 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 208596002598 Catalytic site; other site 208596002599 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 208596002600 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 208596002601 G1 box; other site 208596002602 putative GEF interaction site [polypeptide binding]; other site 208596002603 GTP/Mg2+ binding site [chemical binding]; other site 208596002604 Switch I region; other site 208596002605 G2 box; other site 208596002606 G3 box; other site 208596002607 Switch II region; other site 208596002608 G4 box; other site 208596002609 G5 box; other site 208596002610 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 208596002611 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 208596002612 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 208596002613 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 208596002614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208596002615 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 208596002616 Walker A motif; other site 208596002617 ATP binding site [chemical binding]; other site 208596002618 Walker B motif; other site 208596002619 arginine finger; other site 208596002620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208596002621 Walker A motif; other site 208596002622 ATP binding site [chemical binding]; other site 208596002623 Walker B motif; other site 208596002624 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 208596002625 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 208596002626 dimerization domain swap beta strand [polypeptide binding]; other site 208596002627 regulatory protein interface [polypeptide binding]; other site 208596002628 active site 208596002629 regulatory phosphorylation site [posttranslational modification]; other site 208596002630 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 208596002631 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 208596002632 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 208596002633 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 208596002634 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 208596002635 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 208596002636 aromatic amino acid aminotransferase; Validated; Region: PRK07309 208596002637 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208596002638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208596002639 homodimer interface [polypeptide binding]; other site 208596002640 catalytic residue [active] 208596002641 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 208596002642 homoserine dehydrogenase; Provisional; Region: PRK06349 208596002643 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 208596002644 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 208596002645 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 208596002646 threonine synthase; Reviewed; Region: PRK06721 208596002647 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 208596002648 homodimer interface [polypeptide binding]; other site 208596002649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208596002650 catalytic residue [active] 208596002651 homoserine kinase; Provisional; Region: PRK01212 208596002652 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 208596002653 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 208596002654 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 208596002655 aspartate kinase I; Reviewed; Region: PRK08210 208596002656 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 208596002657 nucleotide binding site [chemical binding]; other site 208596002658 substrate binding site [chemical binding]; other site 208596002659 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 208596002660 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 208596002661 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 208596002662 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596002663 active site 208596002664 motif I; other site 208596002665 motif II; other site 208596002666 GTPase YqeH; Provisional; Region: PRK13796 208596002667 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 208596002668 GTP/Mg2+ binding site [chemical binding]; other site 208596002669 G4 box; other site 208596002670 G5 box; other site 208596002671 G1 box; other site 208596002672 Switch I region; other site 208596002673 G2 box; other site 208596002674 G3 box; other site 208596002675 Switch II region; other site 208596002676 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 208596002677 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 208596002678 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 208596002679 active site 208596002680 (T/H)XGH motif; other site 208596002681 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208596002682 Zn2+ binding site [ion binding]; other site 208596002683 Mg2+ binding site [ion binding]; other site 208596002684 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 208596002685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208596002686 S-adenosylmethionine binding site [chemical binding]; other site 208596002687 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 208596002688 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208596002689 ATP binding site [chemical binding]; other site 208596002690 putative Mg++ binding site [ion binding]; other site 208596002691 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208596002692 nucleotide binding region [chemical binding]; other site 208596002693 ATP-binding site [chemical binding]; other site 208596002694 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 208596002695 HRDC domain; Region: HRDC; pfam00570 208596002696 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 208596002697 hypothetical protein; Provisional; Region: PRK13670 208596002698 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 208596002699 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 208596002700 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 208596002701 cell division protein MraZ; Reviewed; Region: PRK00326 208596002702 MraZ protein; Region: MraZ; pfam02381 208596002703 MraZ protein; Region: MraZ; pfam02381 208596002704 MraW methylase family; Region: Methyltransf_5; pfam01795 208596002705 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 208596002706 Cell division protein FtsL; Region: FtsL; cl11433 208596002707 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 208596002708 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 208596002709 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 208596002710 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 208596002711 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 208596002712 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 208596002713 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 208596002714 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 208596002715 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 208596002716 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 208596002717 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 208596002718 Mg++ binding site [ion binding]; other site 208596002719 putative catalytic motif [active] 208596002720 putative substrate binding site [chemical binding]; other site 208596002721 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 208596002722 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 208596002723 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 208596002724 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 208596002725 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 208596002726 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 208596002727 active site 208596002728 homodimer interface [polypeptide binding]; other site 208596002729 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 208596002730 Cell division protein FtsQ; Region: FtsQ; pfam03799 208596002731 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 208596002732 Cell division protein FtsA; Region: FtsA; smart00842 208596002733 Cell division protein FtsA; Region: FtsA; pfam14450 208596002734 cell division protein FtsZ; Validated; Region: PRK09330 208596002735 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 208596002736 nucleotide binding site [chemical binding]; other site 208596002737 SulA interaction site; other site 208596002738 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 208596002739 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 208596002740 catalytic residue [active] 208596002741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 208596002742 YGGT family; Region: YGGT; pfam02325 208596002743 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 208596002744 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 208596002745 RNA binding surface [nucleotide binding]; other site 208596002746 DivIVA protein; Region: DivIVA; pfam05103 208596002747 DivIVA domain; Region: DivI1A_domain; TIGR03544 208596002748 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 208596002749 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 208596002750 active site 208596002751 HIGH motif; other site 208596002752 nucleotide binding site [chemical binding]; other site 208596002753 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 208596002754 active site 208596002755 KMSKS motif; other site 208596002756 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 208596002757 tRNA binding surface [nucleotide binding]; other site 208596002758 anticodon binding site; other site 208596002759 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 208596002760 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 208596002761 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 208596002762 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 208596002763 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 208596002764 DNA-binding site [nucleotide binding]; DNA binding site 208596002765 RNA-binding motif; other site 208596002766 MarR family; Region: MarR_2; pfam12802 208596002767 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208596002768 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208596002769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596002770 Walker A/P-loop; other site 208596002771 ATP binding site [chemical binding]; other site 208596002772 Q-loop/lid; other site 208596002773 ABC transporter signature motif; other site 208596002774 Walker B; other site 208596002775 D-loop; other site 208596002776 H-loop/switch region; other site 208596002777 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208596002778 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208596002779 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 208596002780 Walker A/P-loop; other site 208596002781 ATP binding site [chemical binding]; other site 208596002782 Q-loop/lid; other site 208596002783 ABC transporter signature motif; other site 208596002784 Walker B; other site 208596002785 D-loop; other site 208596002786 H-loop/switch region; other site 208596002787 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 208596002788 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 208596002789 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 208596002790 dimer interface [polypeptide binding]; other site 208596002791 ADP-ribose binding site [chemical binding]; other site 208596002792 active site 208596002793 nudix motif; other site 208596002794 metal binding site [ion binding]; metal-binding site 208596002795 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 208596002796 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 208596002797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596002798 Coenzyme A binding pocket [chemical binding]; other site 208596002799 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 208596002800 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 208596002801 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 208596002802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 208596002803 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 208596002804 S-ribosylhomocysteinase; Provisional; Region: PRK02260 208596002805 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 208596002806 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 208596002807 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 208596002808 RNA binding surface [nucleotide binding]; other site 208596002809 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 208596002810 GAF domain; Region: GAF_2; pfam13185 208596002811 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 208596002812 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 208596002813 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 208596002814 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208596002815 catalytic residue [active] 208596002816 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 208596002817 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 208596002818 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 208596002819 Ligand Binding Site [chemical binding]; other site 208596002820 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 208596002821 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 208596002822 active site 208596002823 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 208596002824 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 208596002825 CoA binding domain; Region: CoA_binding; pfam02629 208596002826 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 208596002827 dimer interface [polypeptide binding]; other site 208596002828 catalytic triad [active] 208596002829 peroxidatic and resolving cysteines [active] 208596002830 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 208596002831 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 208596002832 active site 208596002833 HIGH motif; other site 208596002834 nucleotide binding site [chemical binding]; other site 208596002835 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 208596002836 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 208596002837 active site 208596002838 KMSKS motif; other site 208596002839 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 208596002840 tRNA binding surface [nucleotide binding]; other site 208596002841 anticodon binding site; other site 208596002842 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 208596002843 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 208596002844 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 208596002845 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 208596002846 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 208596002847 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596002848 motif II; other site 208596002849 hypothetical protein; Reviewed; Region: PRK00024 208596002850 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 208596002851 MPN+ (JAMM) motif; other site 208596002852 Zinc-binding site [ion binding]; other site 208596002853 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 208596002854 DNA-binding site [nucleotide binding]; DNA binding site 208596002855 RNA-binding motif; other site 208596002856 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 208596002857 DNA-binding site [nucleotide binding]; DNA binding site 208596002858 RNA-binding motif; other site 208596002859 rod shape-determining protein MreB; Provisional; Region: PRK13927 208596002860 MreB and similar proteins; Region: MreB_like; cd10225 208596002861 nucleotide binding site [chemical binding]; other site 208596002862 Mg binding site [ion binding]; other site 208596002863 putative protofilament interaction site [polypeptide binding]; other site 208596002864 RodZ interaction site [polypeptide binding]; other site 208596002865 rod shape-determining protein MreC; Provisional; Region: PRK13922 208596002866 rod shape-determining protein MreC; Region: MreC; pfam04085 208596002867 rod shape-determining protein MreD; Region: MreD; cl01087 208596002868 septum formation inhibitor; Reviewed; Region: minC; PRK00513 208596002869 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 208596002870 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 208596002871 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 208596002872 Switch I; other site 208596002873 Switch II; other site 208596002874 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208596002875 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208596002876 substrate binding pocket [chemical binding]; other site 208596002877 membrane-bound complex binding site; other site 208596002878 hinge residues; other site 208596002879 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208596002880 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208596002881 substrate binding pocket [chemical binding]; other site 208596002882 membrane-bound complex binding site; other site 208596002883 hinge residues; other site 208596002884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596002885 dimer interface [polypeptide binding]; other site 208596002886 conserved gate region; other site 208596002887 putative PBP binding loops; other site 208596002888 ABC-ATPase subunit interface; other site 208596002889 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596002890 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 208596002891 Walker A/P-loop; other site 208596002892 ATP binding site [chemical binding]; other site 208596002893 Q-loop/lid; other site 208596002894 ABC transporter signature motif; other site 208596002895 Walker B; other site 208596002896 D-loop; other site 208596002897 H-loop/switch region; other site 208596002898 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 208596002899 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 208596002900 Protein of unknown function (DUF464); Region: DUF464; pfam04327 208596002901 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 208596002902 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 208596002903 Methyltransferase domain; Region: Methyltransf_26; pfam13659 208596002904 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 208596002905 propionate/acetate kinase; Provisional; Region: PRK12379 208596002906 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 208596002907 Ligand Binding Site [chemical binding]; other site 208596002908 recombination factor protein RarA; Reviewed; Region: PRK13342 208596002909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208596002910 Walker A motif; other site 208596002911 ATP binding site [chemical binding]; other site 208596002912 Walker B motif; other site 208596002913 arginine finger; other site 208596002914 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 208596002915 SUR7/PalI family; Region: SUR7; pfam06687 208596002916 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 208596002917 putative nucleotide binding site [chemical binding]; other site 208596002918 putative metal binding site [ion binding]; other site 208596002919 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 208596002920 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 208596002921 ATP-grasp domain; Region: ATP-grasp_4; cl17255 208596002922 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 208596002923 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 208596002924 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208596002925 catalytic residue [active] 208596002926 Putative amino acid metabolism; Region: DUF1831; pfam08866 208596002927 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 208596002928 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 208596002929 Ligand Binding Site [chemical binding]; other site 208596002930 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208596002931 TPR motif; other site 208596002932 TPR repeat; Region: TPR_11; pfam13414 208596002933 binding surface 208596002934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208596002935 TPR motif; other site 208596002936 binding surface 208596002937 TPR repeat; Region: TPR_11; pfam13414 208596002938 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 208596002939 AAA domain; Region: AAA_30; pfam13604 208596002940 Family description; Region: UvrD_C_2; pfam13538 208596002941 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 208596002942 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 208596002943 Uncharacterized conserved protein [Function unknown]; Region: COG1284 208596002944 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 208596002945 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 208596002946 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 208596002947 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 208596002948 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 208596002949 motif 1; other site 208596002950 active site 208596002951 motif 2; other site 208596002952 motif 3; other site 208596002953 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 208596002954 DHHA1 domain; Region: DHHA1; pfam02272 208596002955 hypothetical protein; Provisional; Region: PRK05473 208596002956 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 208596002957 hypothetical protein; Provisional; Region: PRK13678 208596002958 YceG-like family; Region: YceG; pfam02618 208596002959 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 208596002960 dimerization interface [polypeptide binding]; other site 208596002961 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 208596002962 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 208596002963 Sugar specificity; other site 208596002964 Pyrimidine base specificity; other site 208596002965 ATP-binding site [chemical binding]; other site 208596002966 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 208596002967 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 208596002968 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 208596002969 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 208596002970 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 208596002971 Histidine kinase; Region: HisKA_3; pfam07730 208596002972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208596002973 ATP binding site [chemical binding]; other site 208596002974 Mg2+ binding site [ion binding]; other site 208596002975 G-X-G motif; other site 208596002976 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 208596002977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208596002978 active site 208596002979 phosphorylation site [posttranslational modification] 208596002980 intermolecular recognition site; other site 208596002981 dimerization interface [polypeptide binding]; other site 208596002982 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 208596002983 DNA binding residues [nucleotide binding] 208596002984 dimerization interface [polypeptide binding]; other site 208596002985 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 208596002986 TrkA-N domain; Region: TrkA_N; pfam02254 208596002987 TrkA-C domain; Region: TrkA_C; pfam02080 208596002988 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 208596002989 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 208596002990 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 208596002991 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 208596002992 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208596002993 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208596002994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596002995 Walker A/P-loop; other site 208596002996 ATP binding site [chemical binding]; other site 208596002997 Q-loop/lid; other site 208596002998 ABC transporter signature motif; other site 208596002999 Walker B; other site 208596003000 D-loop; other site 208596003001 H-loop/switch region; other site 208596003002 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208596003003 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208596003004 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 208596003005 Walker A/P-loop; other site 208596003006 ATP binding site [chemical binding]; other site 208596003007 Q-loop/lid; other site 208596003008 ABC transporter signature motif; other site 208596003009 Walker B; other site 208596003010 D-loop; other site 208596003011 H-loop/switch region; other site 208596003012 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 208596003013 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596003014 active site 208596003015 motif I; other site 208596003016 motif II; other site 208596003017 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596003018 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 208596003019 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 208596003020 Int/Topo IB signature motif; other site 208596003021 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208596003022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596003023 non-specific DNA binding site [nucleotide binding]; other site 208596003024 salt bridge; other site 208596003025 sequence-specific DNA binding site [nucleotide binding]; other site 208596003026 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 208596003027 Helix-turn-helix domain; Region: HTH_17; pfam12728 208596003028 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 208596003029 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 208596003030 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 208596003031 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 208596003032 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 208596003033 aminoacyl-tRNA ligase; Region: PLN02959 208596003034 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 208596003035 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 208596003036 PYR/PP interface [polypeptide binding]; other site 208596003037 tetramer interface [polypeptide binding]; other site 208596003038 dimer interface [polypeptide binding]; other site 208596003039 TPP binding site [chemical binding]; other site 208596003040 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 208596003041 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 208596003042 TPP-binding site [chemical binding]; other site 208596003043 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 208596003044 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208596003045 DNA-binding site [nucleotide binding]; DNA binding site 208596003046 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 208596003047 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 208596003048 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 208596003049 active site turn [active] 208596003050 phosphorylation site [posttranslational modification] 208596003051 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 208596003052 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 208596003053 beta-galactosidase; Region: BGL; TIGR03356 208596003054 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 208596003055 active site 208596003056 catalytic residues [active] 208596003057 metal binding site [ion binding]; metal-binding site 208596003058 glutamate dehydrogenase; Provisional; Region: PRK09414 208596003059 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 208596003060 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 208596003061 NAD(P) binding site [chemical binding]; other site 208596003062 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 208596003063 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 208596003064 TPP-binding site [chemical binding]; other site 208596003065 heterodimer interface [polypeptide binding]; other site 208596003066 tetramer interface [polypeptide binding]; other site 208596003067 phosphorylation loop region [posttranslational modification] 208596003068 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 208596003069 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 208596003070 alpha subunit interface [polypeptide binding]; other site 208596003071 TPP binding site [chemical binding]; other site 208596003072 heterodimer interface [polypeptide binding]; other site 208596003073 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 208596003074 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 208596003075 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 208596003076 E3 interaction surface; other site 208596003077 lipoyl attachment site [posttranslational modification]; other site 208596003078 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 208596003079 E3 interaction surface; other site 208596003080 lipoyl attachment site [posttranslational modification]; other site 208596003081 e3 binding domain; Region: E3_binding; pfam02817 208596003082 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 208596003083 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 208596003084 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 208596003085 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208596003086 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 208596003087 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 208596003088 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 208596003089 LDH/MDH dimer interface [polypeptide binding]; other site 208596003090 NAD(P) binding site [chemical binding]; other site 208596003091 substrate binding site [chemical binding]; other site 208596003092 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 208596003093 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 208596003094 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 208596003095 active site 208596003096 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 208596003097 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 208596003098 G1 box; other site 208596003099 putative GEF interaction site [polypeptide binding]; other site 208596003100 GTP/Mg2+ binding site [chemical binding]; other site 208596003101 Switch I region; other site 208596003102 G2 box; other site 208596003103 G3 box; other site 208596003104 Switch II region; other site 208596003105 G4 box; other site 208596003106 G5 box; other site 208596003107 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 208596003108 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 208596003109 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 208596003110 pyruvate carboxylase; Reviewed; Region: PRK12999 208596003111 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 208596003112 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 208596003113 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 208596003114 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 208596003115 active site 208596003116 catalytic residues [active] 208596003117 metal binding site [ion binding]; metal-binding site 208596003118 homodimer binding site [polypeptide binding]; other site 208596003119 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 208596003120 carboxyltransferase (CT) interaction site; other site 208596003121 biotinylation site [posttranslational modification]; other site 208596003122 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 208596003123 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 208596003124 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 208596003125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208596003126 S-adenosylmethionine binding site [chemical binding]; other site 208596003127 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 208596003128 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 208596003129 active site 208596003130 (T/H)XGH motif; other site 208596003131 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 208596003132 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 208596003133 protein binding site [polypeptide binding]; other site 208596003134 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 208596003135 SLBB domain; Region: SLBB; pfam10531 208596003136 comEA protein; Region: comE; TIGR01259 208596003137 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 208596003138 catalytic motif [active] 208596003139 Zn binding site [ion binding]; other site 208596003140 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 208596003141 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 208596003142 Competence protein; Region: Competence; pfam03772 208596003143 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 208596003144 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 208596003145 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 208596003146 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 208596003147 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 208596003148 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 208596003149 excinuclease ABC subunit B; Provisional; Region: PRK05298 208596003150 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208596003151 ATP binding site [chemical binding]; other site 208596003152 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208596003153 nucleotide binding region [chemical binding]; other site 208596003154 ATP-binding site [chemical binding]; other site 208596003155 Ultra-violet resistance protein B; Region: UvrB; pfam12344 208596003156 UvrB/uvrC motif; Region: UVR; pfam02151 208596003157 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 208596003158 16S/18S rRNA binding site [nucleotide binding]; other site 208596003159 S13e-L30e interaction site [polypeptide binding]; other site 208596003160 25S rRNA binding site [nucleotide binding]; other site 208596003161 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 208596003162 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 208596003163 RNase E interface [polypeptide binding]; other site 208596003164 trimer interface [polypeptide binding]; other site 208596003165 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 208596003166 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 208596003167 RNase E interface [polypeptide binding]; other site 208596003168 trimer interface [polypeptide binding]; other site 208596003169 active site 208596003170 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 208596003171 putative nucleic acid binding region [nucleotide binding]; other site 208596003172 G-X-X-G motif; other site 208596003173 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 208596003174 RNA binding site [nucleotide binding]; other site 208596003175 domain interface; other site 208596003176 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 208596003177 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 208596003178 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 208596003179 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 208596003180 dihydrodipicolinate synthase; Region: dapA; TIGR00674 208596003181 dimer interface [polypeptide binding]; other site 208596003182 active site 208596003183 catalytic residue [active] 208596003184 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 208596003185 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 208596003186 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 208596003187 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 208596003188 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 208596003189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596003190 dimer interface [polypeptide binding]; other site 208596003191 conserved gate region; other site 208596003192 putative PBP binding loops; other site 208596003193 ABC-ATPase subunit interface; other site 208596003194 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 208596003195 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 208596003196 Walker A/P-loop; other site 208596003197 ATP binding site [chemical binding]; other site 208596003198 Q-loop/lid; other site 208596003199 ABC transporter signature motif; other site 208596003200 Walker B; other site 208596003201 D-loop; other site 208596003202 H-loop/switch region; other site 208596003203 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 208596003204 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 208596003205 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208596003206 Zn2+ binding site [ion binding]; other site 208596003207 Mg2+ binding site [ion binding]; other site 208596003208 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 208596003209 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 208596003210 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 208596003211 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 208596003212 putative active site [active] 208596003213 catalytic site [active] 208596003214 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 208596003215 putative active site [active] 208596003216 catalytic site [active] 208596003217 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 208596003218 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 208596003219 Walker A/P-loop; other site 208596003220 ATP binding site [chemical binding]; other site 208596003221 Q-loop/lid; other site 208596003222 ABC transporter signature motif; other site 208596003223 Walker B; other site 208596003224 D-loop; other site 208596003225 H-loop/switch region; other site 208596003226 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 208596003227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596003228 dimer interface [polypeptide binding]; other site 208596003229 conserved gate region; other site 208596003230 putative PBP binding loops; other site 208596003231 ABC-ATPase subunit interface; other site 208596003232 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 208596003233 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 208596003234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596003235 dimer interface [polypeptide binding]; other site 208596003236 conserved gate region; other site 208596003237 putative PBP binding loops; other site 208596003238 ABC-ATPase subunit interface; other site 208596003239 EDD domain protein, DegV family; Region: DegV; TIGR00762 208596003240 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 208596003241 V-type ATP synthase subunit I; Validated; Region: PRK05771 208596003242 V-type ATP synthase subunit K; Validated; Region: PRK06558 208596003243 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 208596003244 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 208596003245 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 208596003246 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 208596003247 V-type ATP synthase subunit F; Provisional; Region: PRK01395 208596003248 V-type ATP synthase subunit A; Provisional; Region: PRK04192 208596003249 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 208596003250 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 208596003251 Walker A motif/ATP binding site; other site 208596003252 Walker B motif; other site 208596003253 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 208596003254 V-type ATP synthase subunit B; Provisional; Region: PRK04196 208596003255 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 208596003256 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 208596003257 Walker A motif homologous position; other site 208596003258 Walker B motif; other site 208596003259 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 208596003260 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 208596003261 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 208596003262 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 208596003263 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 208596003264 catalytic site [active] 208596003265 G-X2-G-X-G-K; other site 208596003266 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 208596003267 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 208596003268 Flavoprotein; Region: Flavoprotein; pfam02441 208596003269 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 208596003270 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 208596003271 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208596003272 ATP binding site [chemical binding]; other site 208596003273 putative Mg++ binding site [ion binding]; other site 208596003274 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208596003275 nucleotide binding region [chemical binding]; other site 208596003276 ATP-binding site [chemical binding]; other site 208596003277 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 208596003278 active site 208596003279 catalytic residues [active] 208596003280 metal binding site [ion binding]; metal-binding site 208596003281 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 208596003282 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 208596003283 putative active site [active] 208596003284 substrate binding site [chemical binding]; other site 208596003285 putative cosubstrate binding site; other site 208596003286 catalytic site [active] 208596003287 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 208596003288 substrate binding site [chemical binding]; other site 208596003289 16S rRNA methyltransferase B; Provisional; Region: PRK14902 208596003290 NusB family; Region: NusB; pfam01029 208596003291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208596003292 S-adenosylmethionine binding site [chemical binding]; other site 208596003293 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 208596003294 active site 208596003295 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 208596003296 Catalytic domain of Protein Kinases; Region: PKc; cd00180 208596003297 active site 208596003298 ATP binding site [chemical binding]; other site 208596003299 substrate binding site [chemical binding]; other site 208596003300 activation loop (A-loop); other site 208596003301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 208596003302 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 208596003303 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 208596003304 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 208596003305 GTPase RsgA; Reviewed; Region: PRK00098 208596003306 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 208596003307 RNA binding site [nucleotide binding]; other site 208596003308 homodimer interface [polypeptide binding]; other site 208596003309 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 208596003310 GTPase/Zn-binding domain interface [polypeptide binding]; other site 208596003311 GTP/Mg2+ binding site [chemical binding]; other site 208596003312 G4 box; other site 208596003313 G5 box; other site 208596003314 G1 box; other site 208596003315 Switch I region; other site 208596003316 G2 box; other site 208596003317 G3 box; other site 208596003318 Switch II region; other site 208596003319 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 208596003320 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 208596003321 substrate binding site [chemical binding]; other site 208596003322 hexamer interface [polypeptide binding]; other site 208596003323 metal binding site [ion binding]; metal-binding site 208596003324 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 208596003325 Thiamine pyrophosphokinase; Region: TPK; cd07995 208596003326 active site 208596003327 dimerization interface [polypeptide binding]; other site 208596003328 thiamine binding site [chemical binding]; other site 208596003329 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 208596003330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 208596003331 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 208596003332 DAK2 domain; Region: Dak2; pfam02734 208596003333 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 208596003334 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 208596003335 generic binding surface II; other site 208596003336 ssDNA binding site; other site 208596003337 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208596003338 ATP binding site [chemical binding]; other site 208596003339 putative Mg++ binding site [ion binding]; other site 208596003340 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208596003341 nucleotide binding region [chemical binding]; other site 208596003342 ATP-binding site [chemical binding]; other site 208596003343 putative phosphate acyltransferase; Provisional; Region: PRK05331 208596003344 acyl carrier protein; Provisional; Region: acpP; PRK00982 208596003345 ribonuclease III; Reviewed; Region: rnc; PRK00102 208596003346 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 208596003347 dimerization interface [polypeptide binding]; other site 208596003348 active site 208596003349 metal binding site [ion binding]; metal-binding site 208596003350 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 208596003351 dsRNA binding site [nucleotide binding]; other site 208596003352 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 208596003353 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 208596003354 Walker A/P-loop; other site 208596003355 ATP binding site [chemical binding]; other site 208596003356 Q-loop/lid; other site 208596003357 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 208596003358 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 208596003359 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 208596003360 ABC transporter signature motif; other site 208596003361 Walker B; other site 208596003362 D-loop; other site 208596003363 H-loop/switch region; other site 208596003364 sugar phosphate phosphatase; Provisional; Region: PRK10513 208596003365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596003366 active site 208596003367 motif I; other site 208596003368 motif II; other site 208596003369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596003370 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 208596003371 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 208596003372 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 208596003373 P loop; other site 208596003374 GTP binding site [chemical binding]; other site 208596003375 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 208596003376 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 208596003377 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 208596003378 active site turn [active] 208596003379 phosphorylation site [posttranslational modification] 208596003380 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 208596003381 active site turn [active] 208596003382 phosphorylation site [posttranslational modification] 208596003383 putative DNA-binding protein; Validated; Region: PRK00118 208596003384 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 208596003385 signal recognition particle protein; Provisional; Region: PRK10867 208596003386 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 208596003387 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 208596003388 P loop; other site 208596003389 GTP binding site [chemical binding]; other site 208596003390 Signal peptide binding domain; Region: SRP_SPB; pfam02978 208596003391 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 208596003392 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 208596003393 KH domain; Region: KH_4; pfam13083 208596003394 G-X-X-G motif; other site 208596003395 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 208596003396 RimM N-terminal domain; Region: RimM; pfam01782 208596003397 PRC-barrel domain; Region: PRC; pfam05239 208596003398 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 208596003399 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 208596003400 OsmC-like protein; Region: OsmC; pfam02566 208596003401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 208596003402 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 208596003403 Uncharacterized conserved protein [Function unknown]; Region: COG1284 208596003404 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 208596003405 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 208596003406 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 208596003407 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 208596003408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596003409 active site 208596003410 motif I; other site 208596003411 motif II; other site 208596003412 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 208596003413 esterase; Provisional; Region: PRK10566 208596003414 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 208596003415 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 208596003416 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 208596003417 Clp amino terminal domain; Region: Clp_N; pfam02861 208596003418 Clp amino terminal domain; Region: Clp_N; pfam02861 208596003419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208596003420 Walker A motif; other site 208596003421 ATP binding site [chemical binding]; other site 208596003422 Walker B motif; other site 208596003423 arginine finger; other site 208596003424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208596003425 Walker A motif; other site 208596003426 ATP binding site [chemical binding]; other site 208596003427 Walker B motif; other site 208596003428 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 208596003429 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 208596003430 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 208596003431 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 208596003432 active site 208596003433 PHP Thumb interface [polypeptide binding]; other site 208596003434 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 208596003435 generic binding surface II; other site 208596003436 generic binding surface I; other site 208596003437 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 208596003438 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 208596003439 active site 208596003440 ADP/pyrophosphate binding site [chemical binding]; other site 208596003441 dimerization interface [polypeptide binding]; other site 208596003442 allosteric effector site; other site 208596003443 fructose-1,6-bisphosphate binding site; other site 208596003444 pyruvate kinase; Provisional; Region: PRK06354 208596003445 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 208596003446 domain interfaces; other site 208596003447 active site 208596003448 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 208596003449 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 208596003450 S1 domain; Region: S1_2; pfam13509 208596003451 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 208596003452 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 208596003453 active site 208596003454 Int/Topo IB signature motif; other site 208596003455 phosphopentomutase; Provisional; Region: PRK05362 208596003456 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 208596003457 purine nucleoside phosphorylase; Provisional; Region: PRK08202 208596003458 diaminopimelate decarboxylase; Region: lysA; TIGR01048 208596003459 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 208596003460 active site 208596003461 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 208596003462 substrate binding site [chemical binding]; other site 208596003463 catalytic residues [active] 208596003464 dimer interface [polypeptide binding]; other site 208596003465 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 208596003466 Coenzyme A binding pocket [chemical binding]; other site 208596003467 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 208596003468 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 208596003469 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 208596003470 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 208596003471 RNA binding surface [nucleotide binding]; other site 208596003472 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 208596003473 active site 208596003474 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208596003475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208596003476 active site 208596003477 phosphorylation site [posttranslational modification] 208596003478 intermolecular recognition site; other site 208596003479 dimerization interface [polypeptide binding]; other site 208596003480 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208596003481 DNA binding site [nucleotide binding] 208596003482 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 208596003483 dimerization interface [polypeptide binding]; other site 208596003484 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 208596003485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208596003486 dimer interface [polypeptide binding]; other site 208596003487 phosphorylation site [posttranslational modification] 208596003488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208596003489 ATP binding site [chemical binding]; other site 208596003490 Mg2+ binding site [ion binding]; other site 208596003491 G-X-G motif; other site 208596003492 Predicted membrane protein [Function unknown]; Region: COG3601 208596003493 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 208596003494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 208596003495 ATP-dependent DNA helicase, RecQ family; Region: recQ_fam; TIGR00614 208596003496 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208596003497 ATP binding site [chemical binding]; other site 208596003498 putative Mg++ binding site [ion binding]; other site 208596003499 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208596003500 nucleotide binding region [chemical binding]; other site 208596003501 ATP-binding site [chemical binding]; other site 208596003502 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 208596003503 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596003504 cytidylate kinase; Provisional; Region: cmk; PRK00023 208596003505 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 208596003506 CMP-binding site; other site 208596003507 The sites determining sugar specificity; other site 208596003508 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 208596003509 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 208596003510 RNA binding site [nucleotide binding]; other site 208596003511 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 208596003512 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 208596003513 RNA binding site [nucleotide binding]; other site 208596003514 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 208596003515 RNA binding site [nucleotide binding]; other site 208596003516 GTP-binding protein Der; Reviewed; Region: PRK00093 208596003517 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 208596003518 G1 box; other site 208596003519 GTP/Mg2+ binding site [chemical binding]; other site 208596003520 Switch I region; other site 208596003521 G2 box; other site 208596003522 Switch II region; other site 208596003523 G3 box; other site 208596003524 G4 box; other site 208596003525 G5 box; other site 208596003526 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 208596003527 G1 box; other site 208596003528 GTP/Mg2+ binding site [chemical binding]; other site 208596003529 Switch I region; other site 208596003530 G2 box; other site 208596003531 G3 box; other site 208596003532 Switch II region; other site 208596003533 G4 box; other site 208596003534 G5 box; other site 208596003535 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 208596003536 IHF dimer interface [polypeptide binding]; other site 208596003537 IHF - DNA interface [nucleotide binding]; other site 208596003538 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208596003539 PAS fold; Region: PAS_3; pfam08447 208596003540 putative active site [active] 208596003541 heme pocket [chemical binding]; other site 208596003542 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 208596003543 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208596003544 metal binding site [ion binding]; metal-binding site 208596003545 active site 208596003546 I-site; other site 208596003547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208596003548 TPR motif; other site 208596003549 binding surface 208596003550 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208596003551 TPR motif; other site 208596003552 binding surface 208596003553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 208596003554 binding surface 208596003555 TPR motif; other site 208596003556 hypothetical protein; Provisional; Region: PRK03636 208596003557 UPF0302 domain; Region: UPF0302; pfam08864 208596003558 IDEAL domain; Region: IDEAL; cl07452 208596003559 Uncharacterized conserved protein [Function unknown]; Region: COG1284 208596003560 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 208596003561 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 208596003562 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 208596003563 dihydrodipicolinate reductase; Provisional; Region: PRK00048 208596003564 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 208596003565 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 208596003566 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 208596003567 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 208596003568 active site 208596003569 NTP binding site [chemical binding]; other site 208596003570 metal binding triad [ion binding]; metal-binding site 208596003571 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 208596003572 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 208596003573 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 208596003574 dimer interface [polypeptide binding]; other site 208596003575 FMN binding site [chemical binding]; other site 208596003576 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 208596003577 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 208596003578 active site 208596003579 catalytic site [active] 208596003580 substrate binding site [chemical binding]; other site 208596003581 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 208596003582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 208596003583 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 208596003584 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 208596003585 putative dimer interface [polypeptide binding]; other site 208596003586 putative anticodon binding site; other site 208596003587 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 208596003588 homodimer interface [polypeptide binding]; other site 208596003589 motif 1; other site 208596003590 motif 2; other site 208596003591 active site 208596003592 motif 3; other site 208596003593 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 208596003594 Helix-turn-helix domain; Region: HTH_36; pfam13730 208596003595 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 208596003596 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 208596003597 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 208596003598 minor groove reading motif; other site 208596003599 helix-hairpin-helix signature motif; other site 208596003600 substrate binding pocket [chemical binding]; other site 208596003601 active site 208596003602 Transglycosylase; Region: Transgly; pfam00912 208596003603 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 208596003604 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 208596003605 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 208596003606 hypothetical protein; Provisional; Region: PRK13660 208596003607 cell division protein GpsB; Provisional; Region: PRK14127 208596003608 DivIVA domain; Region: DivI1A_domain; TIGR03544 208596003609 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 208596003610 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 208596003611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 208596003612 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 208596003613 active site 208596003614 RNA/DNA hybrid binding site [nucleotide binding]; other site 208596003615 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 208596003616 DNA-binding site [nucleotide binding]; DNA binding site 208596003617 RNA-binding motif; other site 208596003618 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 208596003619 Fe-S cluster binding site [ion binding]; other site 208596003620 active site 208596003621 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 208596003622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596003623 Walker A/P-loop; other site 208596003624 ATP binding site [chemical binding]; other site 208596003625 Q-loop/lid; other site 208596003626 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 208596003627 ABC transporter signature motif; other site 208596003628 Walker B; other site 208596003629 D-loop; other site 208596003630 ABC transporter; Region: ABC_tran_2; pfam12848 208596003631 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 208596003632 thymidylate synthase; Region: thym_sym; TIGR03284 208596003633 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 208596003634 dimerization interface [polypeptide binding]; other site 208596003635 active site 208596003636 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 208596003637 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 208596003638 folate binding site [chemical binding]; other site 208596003639 NADP+ binding site [chemical binding]; other site 208596003640 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 208596003641 active site 208596003642 catalytic triad [active] 208596003643 oxyanion hole [active] 208596003644 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 208596003645 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 208596003646 hypothetical protein; Provisional; Region: PRK13672 208596003647 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 208596003648 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 208596003649 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 208596003650 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 208596003651 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 208596003652 protein binding site [polypeptide binding]; other site 208596003653 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 208596003654 Catalytic dyad [active] 208596003655 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 208596003656 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 208596003657 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 208596003658 Catalytic site [active] 208596003659 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 208596003660 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 208596003661 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 208596003662 Catalytic site [active] 208596003663 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 208596003664 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 208596003665 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 208596003666 GTP/Mg2+ binding site [chemical binding]; other site 208596003667 G4 box; other site 208596003668 G5 box; other site 208596003669 G1 box; other site 208596003670 Switch I region; other site 208596003671 G2 box; other site 208596003672 G3 box; other site 208596003673 Switch II region; other site 208596003674 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 208596003675 RNA/DNA hybrid binding site [nucleotide binding]; other site 208596003676 active site 208596003677 LexA repressor; Validated; Region: PRK00215 208596003678 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 208596003679 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 208596003680 Catalytic site [active] 208596003681 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 208596003682 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 208596003683 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 208596003684 TPP-binding site [chemical binding]; other site 208596003685 dimer interface [polypeptide binding]; other site 208596003686 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 208596003687 PYR/PP interface [polypeptide binding]; other site 208596003688 dimer interface [polypeptide binding]; other site 208596003689 TPP binding site [chemical binding]; other site 208596003690 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 208596003691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 208596003692 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208596003693 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 208596003694 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596003695 Walker A/P-loop; other site 208596003696 ATP binding site [chemical binding]; other site 208596003697 Q-loop/lid; other site 208596003698 ABC transporter signature motif; other site 208596003699 Walker B; other site 208596003700 D-loop; other site 208596003701 H-loop/switch region; other site 208596003702 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208596003703 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208596003704 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 208596003705 Walker A/P-loop; other site 208596003706 ATP binding site [chemical binding]; other site 208596003707 Q-loop/lid; other site 208596003708 ABC transporter signature motif; other site 208596003709 Walker B; other site 208596003710 D-loop; other site 208596003711 H-loop/switch region; other site 208596003712 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 208596003713 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 208596003714 putative acyl-acceptor binding pocket; other site 208596003715 SWIM zinc finger; Region: SWIM; pfam04434 208596003716 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 208596003717 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 208596003718 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208596003719 ATP binding site [chemical binding]; other site 208596003720 putative Mg++ binding site [ion binding]; other site 208596003721 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208596003722 nucleotide binding region [chemical binding]; other site 208596003723 ATP-binding site [chemical binding]; other site 208596003724 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 208596003725 rRNA interaction site [nucleotide binding]; other site 208596003726 S8 interaction site; other site 208596003727 putative laminin-1 binding site; other site 208596003728 elongation factor Ts; Provisional; Region: tsf; PRK09377 208596003729 Elongation factor TS; Region: EF_TS; pfam00889 208596003730 Elongation factor TS; Region: EF_TS; pfam00889 208596003731 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 208596003732 putative nucleotide binding site [chemical binding]; other site 208596003733 uridine monophosphate binding site [chemical binding]; other site 208596003734 homohexameric interface [polypeptide binding]; other site 208596003735 ribosome recycling factor; Reviewed; Region: frr; PRK00083 208596003736 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 208596003737 hinge region; other site 208596003738 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 208596003739 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 208596003740 catalytic residue [active] 208596003741 putative FPP diphosphate binding site; other site 208596003742 putative FPP binding hydrophobic cleft; other site 208596003743 dimer interface [polypeptide binding]; other site 208596003744 putative IPP diphosphate binding site; other site 208596003745 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 208596003746 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 208596003747 RIP metalloprotease RseP; Region: TIGR00054 208596003748 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 208596003749 active site 208596003750 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 208596003751 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 208596003752 protein binding site [polypeptide binding]; other site 208596003753 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 208596003754 putative substrate binding region [chemical binding]; other site 208596003755 prolyl-tRNA synthetase; Provisional; Region: PRK09194 208596003756 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 208596003757 dimer interface [polypeptide binding]; other site 208596003758 motif 1; other site 208596003759 active site 208596003760 motif 2; other site 208596003761 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 208596003762 putative deacylase active site [active] 208596003763 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 208596003764 active site 208596003765 motif 3; other site 208596003766 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 208596003767 anticodon binding site; other site 208596003768 DNA polymerase III PolC; Validated; Region: polC; PRK00448 208596003769 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 208596003770 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 208596003771 generic binding surface II; other site 208596003772 generic binding surface I; other site 208596003773 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 208596003774 active site 208596003775 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 208596003776 active site 208596003777 catalytic site [active] 208596003778 substrate binding site [chemical binding]; other site 208596003779 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 208596003780 ribosome maturation protein RimP; Reviewed; Region: PRK00092 208596003781 Sm and related proteins; Region: Sm_like; cl00259 208596003782 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 208596003783 putative oligomer interface [polypeptide binding]; other site 208596003784 putative RNA binding site [nucleotide binding]; other site 208596003785 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 208596003786 NusA N-terminal domain; Region: NusA_N; pfam08529 208596003787 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 208596003788 RNA binding site [nucleotide binding]; other site 208596003789 homodimer interface [polypeptide binding]; other site 208596003790 NusA-like KH domain; Region: KH_5; pfam13184 208596003791 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 208596003792 G-X-X-G motif; other site 208596003793 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 208596003794 putative RNA binding cleft [nucleotide binding]; other site 208596003795 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 208596003796 translation initiation factor IF-2; Validated; Region: infB; PRK05306 208596003797 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 208596003798 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 208596003799 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 208596003800 G1 box; other site 208596003801 putative GEF interaction site [polypeptide binding]; other site 208596003802 GTP/Mg2+ binding site [chemical binding]; other site 208596003803 Switch I region; other site 208596003804 G2 box; other site 208596003805 G3 box; other site 208596003806 Switch II region; other site 208596003807 G4 box; other site 208596003808 G5 box; other site 208596003809 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 208596003810 Translation-initiation factor 2; Region: IF-2; pfam11987 208596003811 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 208596003812 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 208596003813 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 208596003814 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 208596003815 NodB motif; other site 208596003816 active site 208596003817 catalytic site [active] 208596003818 metal binding site [ion binding]; metal-binding site 208596003819 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596003820 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596003821 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 208596003822 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596003823 Uncharacterized conserved protein [Function unknown]; Region: COG5646 208596003824 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 208596003825 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 208596003826 RNA binding site [nucleotide binding]; other site 208596003827 active site 208596003828 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 208596003829 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 208596003830 active site 208596003831 Riboflavin kinase; Region: Flavokinase; smart00904 208596003832 argininosuccinate synthase; Provisional; Region: PRK13820 208596003833 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 208596003834 ANP binding site [chemical binding]; other site 208596003835 Substrate Binding Site II [chemical binding]; other site 208596003836 Substrate Binding Site I [chemical binding]; other site 208596003837 argininosuccinate lyase; Provisional; Region: PRK00855 208596003838 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 208596003839 active sites [active] 208596003840 tetramer interface [polypeptide binding]; other site 208596003841 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 208596003842 GrpE; Region: GrpE; pfam01025 208596003843 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 208596003844 dimer interface [polypeptide binding]; other site 208596003845 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 208596003846 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 208596003847 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 208596003848 nucleotide binding site [chemical binding]; other site 208596003849 NEF interaction site [polypeptide binding]; other site 208596003850 SBD interface [polypeptide binding]; other site 208596003851 chaperone protein DnaJ; Provisional; Region: PRK14276 208596003852 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 208596003853 HSP70 interaction site [polypeptide binding]; other site 208596003854 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 208596003855 substrate binding site [polypeptide binding]; other site 208596003856 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 208596003857 Zn binding sites [ion binding]; other site 208596003858 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 208596003859 dimer interface [polypeptide binding]; other site 208596003860 GTP-binding protein LepA; Provisional; Region: PRK05433 208596003861 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 208596003862 G1 box; other site 208596003863 putative GEF interaction site [polypeptide binding]; other site 208596003864 GTP/Mg2+ binding site [chemical binding]; other site 208596003865 Switch I region; other site 208596003866 G2 box; other site 208596003867 G3 box; other site 208596003868 Switch II region; other site 208596003869 G4 box; other site 208596003870 G5 box; other site 208596003871 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 208596003872 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 208596003873 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 208596003874 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 208596003875 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 208596003876 TIR domain; Region: TIR_2; pfam13676 208596003877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596003878 Coenzyme A binding pocket [chemical binding]; other site 208596003879 Divergent AAA domain; Region: AAA_4; pfam04326 208596003880 Caspase domain; Region: Peptidase_C14; pfam00656 208596003881 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 208596003882 hydrophobic ligand binding site; other site 208596003883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 208596003884 Coenzyme A binding pocket [chemical binding]; other site 208596003885 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 208596003886 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 208596003887 Coenzyme A binding pocket [chemical binding]; other site 208596003888 Predicted membrane protein [Function unknown]; Region: COG2855 208596003889 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208596003890 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208596003891 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 208596003892 putative dimerization interface [polypeptide binding]; other site 208596003893 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 208596003894 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 208596003895 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 208596003896 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 208596003897 Short C-terminal domain; Region: SHOCT; pfam09851 208596003898 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 208596003899 DNA polymerase IV; Reviewed; Region: PRK03103 208596003900 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 208596003901 active site 208596003902 DNA binding site [nucleotide binding] 208596003903 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 208596003904 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208596003905 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 208596003906 active site 208596003907 catalytic tetrad [active] 208596003908 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208596003909 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 208596003910 active site 208596003911 catalytic tetrad [active] 208596003912 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 208596003913 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208596003914 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208596003915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596003916 Walker A/P-loop; other site 208596003917 ATP binding site [chemical binding]; other site 208596003918 Q-loop/lid; other site 208596003919 ABC transporter signature motif; other site 208596003920 Walker B; other site 208596003921 D-loop; other site 208596003922 H-loop/switch region; other site 208596003923 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208596003924 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208596003925 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 208596003926 Walker A/P-loop; other site 208596003927 ATP binding site [chemical binding]; other site 208596003928 Q-loop/lid; other site 208596003929 ABC transporter signature motif; other site 208596003930 Walker B; other site 208596003931 D-loop; other site 208596003932 H-loop/switch region; other site 208596003933 Nuclease-related domain; Region: NERD; pfam08378 208596003934 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 208596003935 active site 208596003936 DNA binding site [nucleotide binding] 208596003937 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 208596003938 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 208596003939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208596003940 S-adenosylmethionine binding site [chemical binding]; other site 208596003941 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 208596003942 RNA methyltransferase, RsmE family; Region: TIGR00046 208596003943 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 208596003944 intersubunit interface [polypeptide binding]; other site 208596003945 active site 208596003946 catalytic residue [active] 208596003947 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 208596003948 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208596003949 Zn2+ binding site [ion binding]; other site 208596003950 Mg2+ binding site [ion binding]; other site 208596003951 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 208596003952 synthetase active site [active] 208596003953 NTP binding site [chemical binding]; other site 208596003954 metal binding site [ion binding]; metal-binding site 208596003955 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 208596003956 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 208596003957 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 208596003958 dimerization interface [polypeptide binding]; other site 208596003959 putative tRNAtyr binding site [nucleotide binding]; other site 208596003960 putative active site [active] 208596003961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 208596003962 Bacterial SH3 domain; Region: SH3_3; pfam08239 208596003963 Bacterial SH3 domain; Region: SH3_3; pfam08239 208596003964 Bacterial SH3 domain homologues; Region: SH3b; smart00287 208596003965 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 208596003966 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 208596003967 active site 208596003968 metal binding site [ion binding]; metal-binding site 208596003969 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 208596003970 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 208596003971 dimer interface [polypeptide binding]; other site 208596003972 motif 1; other site 208596003973 active site 208596003974 motif 2; other site 208596003975 motif 3; other site 208596003976 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 208596003977 anticodon binding site; other site 208596003978 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 208596003979 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 208596003980 dimer interface [polypeptide binding]; other site 208596003981 anticodon binding site; other site 208596003982 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 208596003983 homodimer interface [polypeptide binding]; other site 208596003984 motif 1; other site 208596003985 active site 208596003986 motif 2; other site 208596003987 GAD domain; Region: GAD; pfam02938 208596003988 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 208596003989 motif 3; other site 208596003990 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 208596003991 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 208596003992 tandem repeat interface [polypeptide binding]; other site 208596003993 oligomer interface [polypeptide binding]; other site 208596003994 active site residues [active] 208596003995 RDD family; Region: RDD; pfam06271 208596003996 endonuclease IV; Provisional; Region: PRK01060 208596003997 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 208596003998 AP (apurinic/apyrimidinic) site pocket; other site 208596003999 DNA interaction; other site 208596004000 Metal-binding active site; metal-binding site 208596004001 LemA family; Region: LemA; cl00742 208596004002 Repair protein; Region: Repair_PSII; pfam04536 208596004003 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 208596004004 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 208596004005 dimerization interface 3.5A [polypeptide binding]; other site 208596004006 active site 208596004007 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 208596004008 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 208596004009 metal binding site 2 [ion binding]; metal-binding site 208596004010 putative DNA binding helix; other site 208596004011 metal binding site 1 [ion binding]; metal-binding site 208596004012 dimer interface [polypeptide binding]; other site 208596004013 structural Zn2+ binding site [ion binding]; other site 208596004014 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 208596004015 Yqey-like protein; Region: YqeY; pfam09424 208596004016 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 208596004017 PhoH-like protein; Region: PhoH; pfam02562 208596004018 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 208596004019 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 208596004020 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208596004021 Zn2+ binding site [ion binding]; other site 208596004022 Mg2+ binding site [ion binding]; other site 208596004023 metal-binding heat shock protein; Provisional; Region: PRK00016 208596004024 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 208596004025 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 208596004026 active site 208596004027 catalytic motif [active] 208596004028 Zn binding site [ion binding]; other site 208596004029 GTPase Era; Reviewed; Region: era; PRK00089 208596004030 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 208596004031 G1 box; other site 208596004032 GTP/Mg2+ binding site [chemical binding]; other site 208596004033 Switch I region; other site 208596004034 G2 box; other site 208596004035 Switch II region; other site 208596004036 G3 box; other site 208596004037 G4 box; other site 208596004038 G5 box; other site 208596004039 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 208596004040 Recombination protein O N terminal; Region: RecO_N; pfam11967 208596004041 DNA repair protein RecO; Region: reco; TIGR00613 208596004042 Recombination protein O C terminal; Region: RecO_C; pfam02565 208596004043 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 208596004044 dimer interface [polypeptide binding]; other site 208596004045 motif 1; other site 208596004046 active site 208596004047 motif 2; other site 208596004048 motif 3; other site 208596004049 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 208596004050 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 208596004051 Uncharacterized conserved protein [Function unknown]; Region: COG3189 208596004052 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208596004053 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208596004054 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 208596004055 Walker A/P-loop; other site 208596004056 ATP binding site [chemical binding]; other site 208596004057 Q-loop/lid; other site 208596004058 ABC transporter signature motif; other site 208596004059 Walker B; other site 208596004060 D-loop; other site 208596004061 H-loop/switch region; other site 208596004062 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 208596004063 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 208596004064 putative active site [active] 208596004065 putative metal binding site [ion binding]; other site 208596004066 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 208596004067 HTH domain; Region: HTH_11; pfam08279 208596004068 3H domain; Region: 3H; pfam02829 208596004069 DNA primase; Validated; Region: dnaG; PRK05667 208596004070 CHC2 zinc finger; Region: zf-CHC2; pfam01807 208596004071 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 208596004072 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 208596004073 active site 208596004074 metal binding site [ion binding]; metal-binding site 208596004075 interdomain interaction site; other site 208596004076 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 208596004077 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 208596004078 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 208596004079 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208596004080 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 208596004081 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 208596004082 DNA binding residues [nucleotide binding] 208596004083 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 208596004084 Family of unknown function (DUF633); Region: DUF633; pfam04816 208596004085 Uncharacterized conserved protein [Function unknown]; Region: COG0327 208596004086 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 208596004087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 208596004088 Uncharacterized conserved protein [Function unknown]; Region: COG0327 208596004089 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 208596004090 peptidase T; Region: peptidase-T; TIGR01882 208596004091 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 208596004092 metal binding site [ion binding]; metal-binding site 208596004093 dimer interface [polypeptide binding]; other site 208596004094 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 208596004095 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 208596004096 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 208596004097 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 208596004098 Part of AAA domain; Region: AAA_19; pfam13245 208596004099 Family description; Region: UvrD_C_2; pfam13538 208596004100 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 208596004101 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 208596004102 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 208596004103 DNA binding residues [nucleotide binding] 208596004104 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 208596004105 active site 208596004106 catalytic motif [active] 208596004107 Zn binding site [ion binding]; other site 208596004108 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208596004109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208596004110 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208596004111 dimerization interface [polypeptide binding]; other site 208596004112 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 208596004113 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 208596004114 teramer interface [polypeptide binding]; other site 208596004115 active site 208596004116 FMN binding site [chemical binding]; other site 208596004117 catalytic residues [active] 208596004118 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 208596004119 L-lactate permease; Region: Lactate_perm; cl00701 208596004120 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 208596004121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 208596004122 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208596004123 dimerization interface [polypeptide binding]; other site 208596004124 putative DNA binding site [nucleotide binding]; other site 208596004125 putative Zn2+ binding site [ion binding]; other site 208596004126 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 208596004127 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 208596004128 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 208596004129 Predicted transcriptional regulator [Transcription]; Region: COG1959 208596004130 Transcriptional regulator; Region: Rrf2; pfam02082 208596004131 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 208596004132 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 208596004133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208596004134 S-adenosylmethionine binding site [chemical binding]; other site 208596004135 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 208596004136 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 208596004137 MepB protein; Region: MepB; cl01985 208596004138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596004139 sequence-specific DNA binding site [nucleotide binding]; other site 208596004140 salt bridge; other site 208596004141 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 208596004142 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596004143 non-specific DNA binding site [nucleotide binding]; other site 208596004144 salt bridge; other site 208596004145 sequence-specific DNA binding site [nucleotide binding]; other site 208596004146 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 208596004147 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 208596004148 inhibitor binding site; inhibition site 208596004149 active site 208596004150 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 208596004151 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208596004152 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 208596004153 DNA binding residues [nucleotide binding] 208596004154 Putative zinc-finger; Region: zf-HC2; pfam13490 208596004155 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 208596004156 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 208596004157 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 208596004158 NodB motif; other site 208596004159 active site 208596004160 catalytic site [active] 208596004161 metal binding site [ion binding]; metal-binding site 208596004162 hypothetical protein; Provisional; Region: PRK11281 208596004163 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 208596004164 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 208596004165 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 208596004166 RNA binding surface [nucleotide binding]; other site 208596004167 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 208596004168 active site 208596004169 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 208596004170 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208596004171 active site 208596004172 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 208596004173 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 208596004174 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 208596004175 dihydroorotase; Validated; Region: pyrC; PRK09357 208596004176 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 208596004177 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 208596004178 active site 208596004179 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 208596004180 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 208596004181 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 208596004182 catalytic site [active] 208596004183 subunit interface [polypeptide binding]; other site 208596004184 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 208596004185 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 208596004186 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 208596004187 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 208596004188 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 208596004189 ATP-grasp domain; Region: ATP-grasp_4; cl17255 208596004190 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 208596004191 IMP binding site; other site 208596004192 dimer interface [polypeptide binding]; other site 208596004193 interdomain contacts; other site 208596004194 partial ornithine binding site; other site 208596004195 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 208596004196 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 208596004197 heterodimer interface [polypeptide binding]; other site 208596004198 active site 208596004199 FMN binding site [chemical binding]; other site 208596004200 homodimer interface [polypeptide binding]; other site 208596004201 substrate binding site [chemical binding]; other site 208596004202 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 208596004203 active site 208596004204 dimer interface [polypeptide binding]; other site 208596004205 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208596004206 active site 208596004207 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 208596004208 Domain of unknown function (DUF814); Region: DUF814; pfam05670 208596004209 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 208596004210 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 208596004211 active site 208596004212 zinc binding site [ion binding]; other site 208596004213 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 208596004214 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 208596004215 zinc binding site [ion binding]; other site 208596004216 putative ligand binding site [chemical binding]; other site 208596004217 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 208596004218 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 208596004219 TM-ABC transporter signature motif; other site 208596004220 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 208596004221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596004222 Walker A/P-loop; other site 208596004223 ATP binding site [chemical binding]; other site 208596004224 Q-loop/lid; other site 208596004225 ABC transporter signature motif; other site 208596004226 Walker B; other site 208596004227 D-loop; other site 208596004228 H-loop/switch region; other site 208596004229 Transcriptional regulators [Transcription]; Region: MarR; COG1846 208596004230 MarR family; Region: MarR_2; pfam12802 208596004231 intracellular protease, PfpI family; Region: PfpI; TIGR01382 208596004232 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 208596004233 proposed catalytic triad [active] 208596004234 conserved cys residue [active] 208596004235 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 208596004236 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 208596004237 Walker A/P-loop; other site 208596004238 ATP binding site [chemical binding]; other site 208596004239 Q-loop/lid; other site 208596004240 ABC transporter signature motif; other site 208596004241 Walker B; other site 208596004242 D-loop; other site 208596004243 H-loop/switch region; other site 208596004244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596004245 dimer interface [polypeptide binding]; other site 208596004246 conserved gate region; other site 208596004247 ABC-ATPase subunit interface; other site 208596004248 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 208596004249 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 208596004250 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 208596004251 Predicted membrane protein [Function unknown]; Region: COG4684 208596004252 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 208596004253 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 208596004254 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 208596004255 G1 box; other site 208596004256 GTP/Mg2+ binding site [chemical binding]; other site 208596004257 G2 box; other site 208596004258 Switch I region; other site 208596004259 G3 box; other site 208596004260 Switch II region; other site 208596004261 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 208596004262 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 208596004263 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 208596004264 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 208596004265 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 208596004266 Peptidase M16C associated; Region: M16C_assoc; pfam08367 208596004267 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 208596004268 Predicted acetyltransferase [General function prediction only]; Region: COG2388 208596004269 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 208596004270 putative dimer interface [polypeptide binding]; other site 208596004271 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 208596004272 ligand binding site [chemical binding]; other site 208596004273 Zn binding site [ion binding]; other site 208596004274 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 208596004275 DHH family; Region: DHH; pfam01368 208596004276 DHHA2 domain; Region: DHHA2; pfam02833 208596004277 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 208596004278 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 208596004279 FeS/SAM binding site; other site 208596004280 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 208596004281 Pyruvate formate lyase 1; Region: PFL1; cd01678 208596004282 coenzyme A binding site [chemical binding]; other site 208596004283 active site 208596004284 catalytic residues [active] 208596004285 glycine loop; other site 208596004286 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 208596004287 primary dimer interface [polypeptide binding]; other site 208596004288 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 208596004289 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 208596004290 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 208596004291 CAP-like domain; other site 208596004292 active site 208596004293 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 208596004294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208596004295 ATP binding site [chemical binding]; other site 208596004296 Mg2+ binding site [ion binding]; other site 208596004297 G-X-G motif; other site 208596004298 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 208596004299 anchoring element; other site 208596004300 dimer interface [polypeptide binding]; other site 208596004301 ATP binding site [chemical binding]; other site 208596004302 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 208596004303 active site 208596004304 putative metal-binding site [ion binding]; other site 208596004305 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 208596004306 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 208596004307 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 208596004308 active site 208596004309 catalytic residues [active] 208596004310 transcriptional repressor CodY; Validated; Region: PRK04158 208596004311 CodY GAF-like domain; Region: CodY; pfam06018 208596004312 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 208596004313 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 208596004314 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 208596004315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208596004316 Walker A motif; other site 208596004317 ATP binding site [chemical binding]; other site 208596004318 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 208596004319 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 208596004320 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 208596004321 active site 208596004322 HslU subunit interaction site [polypeptide binding]; other site 208596004323 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 208596004324 active site 208596004325 DNA binding site [nucleotide binding] 208596004326 Int/Topo IB signature motif; other site 208596004327 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 208596004328 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 208596004329 DNA topoisomerase; Region: Topoisom_bac; pfam01131 208596004330 phosphate binding site [ion binding]; other site 208596004331 domain II; other site 208596004332 domain III; other site 208596004333 nucleotide binding site [chemical binding]; other site 208596004334 DNA binding groove [nucleotide binding] 208596004335 catalytic site [active] 208596004336 domain IV; other site 208596004337 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 208596004338 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 208596004339 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 208596004340 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 208596004341 active site 208596004342 interdomain interaction site; other site 208596004343 putative metal-binding site [ion binding]; other site 208596004344 nucleotide binding site [chemical binding]; other site 208596004345 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 208596004346 domain I; other site 208596004347 DNA protecting protein DprA; Region: dprA; TIGR00732 208596004348 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 208596004349 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208596004350 active site 208596004351 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 208596004352 DHH family; Region: DHH; pfam01368 208596004353 DHHA1 domain; Region: DHHA1; pfam02272 208596004354 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 208596004355 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 208596004356 EDD domain protein, DegV family; Region: DegV; TIGR00762 208596004357 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 208596004358 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 208596004359 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 208596004360 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 208596004361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208596004362 NAD(P) binding site [chemical binding]; other site 208596004363 active site 208596004364 ribonuclease Z; Region: RNase_Z; TIGR02651 208596004365 GTPase CgtA; Reviewed; Region: obgE; PRK12297 208596004366 GTP1/OBG; Region: GTP1_OBG; pfam01018 208596004367 Obg GTPase; Region: Obg; cd01898 208596004368 G1 box; other site 208596004369 GTP/Mg2+ binding site [chemical binding]; other site 208596004370 Switch I region; other site 208596004371 G2 box; other site 208596004372 G3 box; other site 208596004373 Switch II region; other site 208596004374 G4 box; other site 208596004375 G5 box; other site 208596004376 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 208596004377 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 208596004378 active site 208596004379 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 208596004380 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 208596004381 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 208596004382 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 208596004383 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 208596004384 putative substrate binding site [chemical binding]; other site 208596004385 putative ATP binding site [chemical binding]; other site 208596004386 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 208596004387 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 208596004388 active site 208596004389 phosphorylation site [posttranslational modification] 208596004390 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 208596004391 active site 208596004392 P-loop; other site 208596004393 phosphorylation site [posttranslational modification] 208596004394 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 208596004395 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 208596004396 Cation efflux family; Region: Cation_efflux; pfam01545 208596004397 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 208596004398 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 208596004399 Walker A/P-loop; other site 208596004400 ATP binding site [chemical binding]; other site 208596004401 Q-loop/lid; other site 208596004402 ABC transporter signature motif; other site 208596004403 Walker B; other site 208596004404 D-loop; other site 208596004405 H-loop/switch region; other site 208596004406 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208596004407 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208596004408 substrate binding pocket [chemical binding]; other site 208596004409 membrane-bound complex binding site; other site 208596004410 hinge residues; other site 208596004411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596004412 dimer interface [polypeptide binding]; other site 208596004413 conserved gate region; other site 208596004414 putative PBP binding loops; other site 208596004415 ABC-ATPase subunit interface; other site 208596004416 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 208596004417 putative metal binding site [ion binding]; other site 208596004418 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 208596004419 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 208596004420 inhibitor-cofactor binding pocket; inhibition site 208596004421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208596004422 catalytic residue [active] 208596004423 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 208596004424 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 208596004425 tRNA; other site 208596004426 putative tRNA binding site [nucleotide binding]; other site 208596004427 putative NADP binding site [chemical binding]; other site 208596004428 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 208596004429 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 208596004430 G1 box; other site 208596004431 GTP/Mg2+ binding site [chemical binding]; other site 208596004432 Switch I region; other site 208596004433 G2 box; other site 208596004434 G3 box; other site 208596004435 Switch II region; other site 208596004436 G4 box; other site 208596004437 G5 box; other site 208596004438 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 208596004439 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 208596004440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208596004441 Walker A motif; other site 208596004442 ATP binding site [chemical binding]; other site 208596004443 Walker B motif; other site 208596004444 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 208596004445 trigger factor; Provisional; Region: tig; PRK01490 208596004446 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 208596004447 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 208596004448 TPR repeat; Region: TPR_11; pfam13414 208596004449 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 208596004450 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 208596004451 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 208596004452 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 208596004453 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 208596004454 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 208596004455 ATP-grasp domain; Region: ATP-grasp_4; cl17255 208596004456 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 208596004457 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 208596004458 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 208596004459 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 208596004460 carboxyltransferase (CT) interaction site; other site 208596004461 biotinylation site [posttranslational modification]; other site 208596004462 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 208596004463 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 208596004464 dimer interface [polypeptide binding]; other site 208596004465 active site 208596004466 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 208596004467 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 208596004468 NAD(P) binding site [chemical binding]; other site 208596004469 homotetramer interface [polypeptide binding]; other site 208596004470 homodimer interface [polypeptide binding]; other site 208596004471 active site 208596004472 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 208596004473 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 208596004474 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 208596004475 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 208596004476 FMN binding site [chemical binding]; other site 208596004477 substrate binding site [chemical binding]; other site 208596004478 putative catalytic residue [active] 208596004479 acyl carrier protein; Provisional; Region: acpP; PRK00982 208596004480 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 208596004481 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 208596004482 dimer interface [polypeptide binding]; other site 208596004483 active site 208596004484 CoA binding pocket [chemical binding]; other site 208596004485 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 208596004486 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 208596004487 MarR family; Region: MarR; pfam01047 208596004488 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 208596004489 Predicted flavoprotein [General function prediction only]; Region: COG0431 208596004490 AAA domain; Region: AAA_18; pfam13238 208596004491 AAA domain; Region: AAA_17; pfam13207 208596004492 FOG: CBS domain [General function prediction only]; Region: COG0517 208596004493 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 208596004494 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 208596004495 Protein of unknown function (DUF975); Region: DUF975; cl10504 208596004496 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 208596004497 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 208596004498 dimer interface [polypeptide binding]; other site 208596004499 putative radical transfer pathway; other site 208596004500 diiron center [ion binding]; other site 208596004501 tyrosyl radical; other site 208596004502 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 208596004503 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 208596004504 Class I ribonucleotide reductase; Region: RNR_I; cd01679 208596004505 active site 208596004506 dimer interface [polypeptide binding]; other site 208596004507 catalytic residues [active] 208596004508 effector binding site; other site 208596004509 R2 peptide binding site; other site 208596004510 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 208596004511 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 208596004512 catalytic residues [active] 208596004513 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 208596004514 pentamer interface [polypeptide binding]; other site 208596004515 dodecaamer interface [polypeptide binding]; other site 208596004516 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 208596004517 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 208596004518 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 208596004519 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 208596004520 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 208596004521 DNA binding residues [nucleotide binding] 208596004522 putative dimer interface [polypeptide binding]; other site 208596004523 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 208596004524 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 208596004525 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 208596004526 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 208596004527 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 208596004528 DNA binding residues [nucleotide binding] 208596004529 putative dimer interface [polypeptide binding]; other site 208596004530 Aluminium resistance protein; Region: Alum_res; pfam06838 208596004531 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 208596004532 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 208596004533 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 208596004534 HflX GTPase family; Region: HflX; cd01878 208596004535 G1 box; other site 208596004536 GTP/Mg2+ binding site [chemical binding]; other site 208596004537 Switch I region; other site 208596004538 G2 box; other site 208596004539 G3 box; other site 208596004540 Switch II region; other site 208596004541 G4 box; other site 208596004542 G5 box; other site 208596004543 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 208596004544 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 208596004545 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 208596004546 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 208596004547 active site 208596004548 catalytic site [active] 208596004549 metal binding site [ion binding]; metal-binding site 208596004550 dimer interface [polypeptide binding]; other site 208596004551 Helix-turn-helix domain; Region: HTH_17; cl17695 208596004552 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 208596004553 active site residue [active] 208596004554 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 208596004555 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 208596004556 nucleotide binding site [chemical binding]; other site 208596004557 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 208596004558 Rhomboid family; Region: Rhomboid; pfam01694 208596004559 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 208596004560 YceG-like family; Region: YceG; pfam02618 208596004561 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 208596004562 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 208596004563 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 208596004564 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 208596004565 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 208596004566 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 208596004567 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 208596004568 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 208596004569 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 208596004570 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 208596004571 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 208596004572 DEAD-like helicases superfamily; Region: DEXDc; smart00487 208596004573 ATP binding site [chemical binding]; other site 208596004574 Mg++ binding site [ion binding]; other site 208596004575 motif III; other site 208596004576 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208596004577 nucleotide binding region [chemical binding]; other site 208596004578 ATP-binding site [chemical binding]; other site 208596004579 K+ potassium transporter; Region: K_trans; pfam02705 208596004580 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 208596004581 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 208596004582 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 208596004583 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208596004584 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 208596004585 active site 208596004586 catalytic tetrad [active] 208596004587 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 208596004588 active site 208596004589 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 208596004590 substrate binding site [chemical binding]; other site 208596004591 metal binding site [ion binding]; metal-binding site 208596004592 Arginine repressor [Transcription]; Region: ArgR; COG1438 208596004593 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 208596004594 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 208596004595 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 208596004596 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 208596004597 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 208596004598 active site 208596004599 HIGH motif; other site 208596004600 KMSK motif region; other site 208596004601 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 208596004602 tRNA binding surface [nucleotide binding]; other site 208596004603 anticodon binding site; other site 208596004604 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 208596004605 putative acyltransferase; Provisional; Region: PRK05790 208596004606 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 208596004607 dimer interface [polypeptide binding]; other site 208596004608 active site 208596004609 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 208596004610 epoxyqueuosine reductase; Region: TIGR00276 208596004611 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 208596004612 Methyltransferase domain; Region: Methyltransf_31; pfam13847 208596004613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208596004614 S-adenosylmethionine binding site [chemical binding]; other site 208596004615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 208596004616 YtxH-like protein; Region: YtxH; pfam12732 208596004617 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 208596004618 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208596004619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208596004620 homodimer interface [polypeptide binding]; other site 208596004621 catalytic residue [active] 208596004622 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 208596004623 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; pfam03977 208596004624 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 208596004625 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 208596004626 carboxyltransferase (CT) interaction site; other site 208596004627 biotinylation site [posttranslational modification]; other site 208596004628 oxaloacetate decarboxylase; Provisional; Region: PRK12331 208596004629 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 208596004630 active site 208596004631 catalytic residues [active] 208596004632 metal binding site [ion binding]; metal-binding site 208596004633 homodimer binding site [polypeptide binding]; other site 208596004634 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 208596004635 active site 208596004636 metal-binding site [ion binding] 208596004637 nucleotide-binding site [chemical binding]; other site 208596004638 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 208596004639 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208596004640 DNA-binding site [nucleotide binding]; DNA binding site 208596004641 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 208596004642 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 208596004643 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 208596004644 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 208596004645 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 208596004646 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 208596004647 putative switch regulator; other site 208596004648 non-specific DNA interactions [nucleotide binding]; other site 208596004649 DNA binding site [nucleotide binding] 208596004650 sequence specific DNA binding site [nucleotide binding]; other site 208596004651 putative cAMP binding site [chemical binding]; other site 208596004652 D-allose kinase; Provisional; Region: PRK09698 208596004653 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 208596004654 nucleotide binding site [chemical binding]; other site 208596004655 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 208596004656 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 208596004657 Ca binding site [ion binding]; other site 208596004658 active site 208596004659 catalytic site [active] 208596004660 beta-phosphoglucomutase; Region: bPGM; TIGR01990 208596004661 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596004662 motif II; other site 208596004663 maltose phosphorylase; Provisional; Region: PRK13807 208596004664 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 208596004665 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 208596004666 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 208596004667 Predicted integral membrane protein [Function unknown]; Region: COG5521 208596004668 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 208596004669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596004670 dimer interface [polypeptide binding]; other site 208596004671 conserved gate region; other site 208596004672 putative PBP binding loops; other site 208596004673 ABC-ATPase subunit interface; other site 208596004674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596004675 dimer interface [polypeptide binding]; other site 208596004676 conserved gate region; other site 208596004677 putative PBP binding loops; other site 208596004678 ABC-ATPase subunit interface; other site 208596004679 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 208596004680 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 208596004681 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 208596004682 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 208596004683 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 208596004684 homodimer interface [polypeptide binding]; other site 208596004685 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 208596004686 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 208596004687 active site 208596004688 homodimer interface [polypeptide binding]; other site 208596004689 catalytic site [active] 208596004690 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 208596004691 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 208596004692 Ca binding site [ion binding]; other site 208596004693 active site 208596004694 catalytic site [active] 208596004695 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 208596004696 active site 208596004697 catalytic site [active] 208596004698 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 208596004699 active site 208596004700 D-serine dehydratase; Provisional; Region: PRK02991 208596004701 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 208596004702 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208596004703 catalytic residue [active] 208596004704 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 208596004705 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 208596004706 Transcriptional regulators [Transcription]; Region: PurR; COG1609 208596004707 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 208596004708 DNA binding site [nucleotide binding] 208596004709 domain linker motif; other site 208596004710 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 208596004711 ligand binding site [chemical binding]; other site 208596004712 dimerization interface [polypeptide binding]; other site 208596004713 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 208596004714 metal binding site 2 [ion binding]; metal-binding site 208596004715 putative DNA binding helix; other site 208596004716 metal binding site 1 [ion binding]; metal-binding site 208596004717 dimer interface [polypeptide binding]; other site 208596004718 structural Zn2+ binding site [ion binding]; other site 208596004719 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 208596004720 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 208596004721 inhibitor-cofactor binding pocket; inhibition site 208596004722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208596004723 catalytic residue [active] 208596004724 Predicted membrane protein [Function unknown]; Region: COG4129 208596004725 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 208596004726 active site 208596004727 hypothetical protein; Provisional; Region: PRK13662 208596004728 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 208596004729 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 208596004730 minor groove reading motif; other site 208596004731 helix-hairpin-helix signature motif; other site 208596004732 substrate binding pocket [chemical binding]; other site 208596004733 active site 208596004734 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 208596004735 DNA binding and oxoG recognition site [nucleotide binding] 208596004736 RecX family; Region: RecX; cl00936 208596004737 Heat induced stress protein YflT; Region: YflT; pfam11181 208596004738 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 208596004739 short chain dehydrogenase; Provisional; Region: PRK06701 208596004740 NAD binding site [chemical binding]; other site 208596004741 metal binding site [ion binding]; metal-binding site 208596004742 active site 208596004743 Heat induced stress protein YflT; Region: YflT; pfam11181 208596004744 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 208596004745 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 208596004746 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 208596004747 amidase catalytic site [active] 208596004748 Zn binding residues [ion binding]; other site 208596004749 substrate binding site [chemical binding]; other site 208596004750 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 208596004751 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596004752 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 208596004753 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 208596004754 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 208596004755 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 208596004756 Substrate-binding site [chemical binding]; other site 208596004757 Substrate specificity [chemical binding]; other site 208596004758 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 208596004759 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 208596004760 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 208596004761 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 208596004762 active site 208596004763 phosphorylation site [posttranslational modification] 208596004764 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 208596004765 HTH domain; Region: HTH_11; pfam08279 208596004766 PRD domain; Region: PRD; pfam00874 208596004767 PRD domain; Region: PRD; pfam00874 208596004768 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 208596004769 active site 208596004770 P-loop; other site 208596004771 phosphorylation site [posttranslational modification] 208596004772 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 208596004773 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 208596004774 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 208596004775 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 208596004776 active site 208596004777 P-loop; other site 208596004778 phosphorylation site [posttranslational modification] 208596004779 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 208596004780 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 208596004781 glutaminase active site [active] 208596004782 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 208596004783 dimer interface [polypeptide binding]; other site 208596004784 active site 208596004785 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 208596004786 dimer interface [polypeptide binding]; other site 208596004787 active site 208596004788 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 208596004789 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 208596004790 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208596004791 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 208596004792 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 208596004793 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 208596004794 active site 208596004795 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 208596004796 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 208596004797 NAD(P) binding site [chemical binding]; other site 208596004798 homodimer interface [polypeptide binding]; other site 208596004799 substrate binding site [chemical binding]; other site 208596004800 active site 208596004801 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 208596004802 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 208596004803 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 208596004804 Chain length determinant protein; Region: Wzz; cl15801 208596004805 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 208596004806 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 208596004807 putative glycosyl transferase; Provisional; Region: PRK10073 208596004808 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 208596004809 active site 208596004810 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 208596004811 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 208596004812 active site 208596004813 O-Antigen ligase; Region: Wzy_C; pfam04932 208596004814 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208596004815 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 208596004816 putative ADP-binding pocket [chemical binding]; other site 208596004817 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 208596004818 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 208596004819 inhibitor-cofactor binding pocket; inhibition site 208596004820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208596004821 catalytic residue [active] 208596004822 Bacterial sugar transferase; Region: Bac_transf; pfam02397 208596004823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596004824 Coenzyme A binding pocket [chemical binding]; other site 208596004825 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 208596004826 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 208596004827 dimerization interface [polypeptide binding]; other site 208596004828 Class I aldolases; Region: Aldolase_Class_I; cl17187 208596004829 catalytic residue [active] 208596004830 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 208596004831 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 208596004832 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 208596004833 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 208596004834 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 208596004835 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 208596004836 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 208596004837 HTH domain; Region: HTH_11; pfam08279 208596004838 PRD domain; Region: PRD; pfam00874 208596004839 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 208596004840 active site 208596004841 P-loop; other site 208596004842 phosphorylation site [posttranslational modification] 208596004843 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 208596004844 active site 208596004845 phosphorylation site [posttranslational modification] 208596004846 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 208596004847 classical (c) SDRs; Region: SDR_c; cd05233 208596004848 NAD(P) binding site [chemical binding]; other site 208596004849 active site 208596004850 sugar phosphate phosphatase; Provisional; Region: PRK10513 208596004851 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596004852 active site 208596004853 motif I; other site 208596004854 motif II; other site 208596004855 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596004856 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 208596004857 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 208596004858 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 208596004859 putative active site [active] 208596004860 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 208596004861 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 208596004862 active site turn [active] 208596004863 phosphorylation site [posttranslational modification] 208596004864 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 208596004865 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 208596004866 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 208596004867 putative active site [active] 208596004868 Uncharacterized conserved protein [Function unknown]; Region: COG3589 208596004869 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 208596004870 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 208596004871 catalytic core [active] 208596004872 Predicted integral membrane protein [Function unknown]; Region: COG5652 208596004873 S-formylglutathione hydrolase; Region: PLN02442 208596004874 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 208596004875 Transcriptional regulators [Transcription]; Region: PurR; COG1609 208596004876 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 208596004877 DNA binding site [nucleotide binding] 208596004878 domain linker motif; other site 208596004879 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 208596004880 dimerization interface [polypeptide binding]; other site 208596004881 ligand binding site [chemical binding]; other site 208596004882 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 208596004883 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 208596004884 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 208596004885 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 208596004886 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 208596004887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596004888 dimer interface [polypeptide binding]; other site 208596004889 conserved gate region; other site 208596004890 putative PBP binding loops; other site 208596004891 ABC-ATPase subunit interface; other site 208596004892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596004893 dimer interface [polypeptide binding]; other site 208596004894 conserved gate region; other site 208596004895 putative PBP binding loops; other site 208596004896 ABC-ATPase subunit interface; other site 208596004897 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 208596004898 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 208596004899 Mga helix-turn-helix domain; Region: Mga; pfam05043 208596004900 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 208596004901 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 208596004902 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 208596004903 ligand binding site [chemical binding]; other site 208596004904 dimerization interface [polypeptide binding]; other site 208596004905 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 208596004906 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 208596004907 TM-ABC transporter signature motif; other site 208596004908 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 208596004909 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 208596004910 Walker A/P-loop; other site 208596004911 ATP binding site [chemical binding]; other site 208596004912 Q-loop/lid; other site 208596004913 ABC transporter signature motif; other site 208596004914 Walker B; other site 208596004915 D-loop; other site 208596004916 H-loop/switch region; other site 208596004917 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 208596004918 D-ribose pyranase; Provisional; Region: PRK11797 208596004919 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 208596004920 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 208596004921 substrate binding site [chemical binding]; other site 208596004922 dimer interface [polypeptide binding]; other site 208596004923 ATP binding site [chemical binding]; other site 208596004924 Transcriptional regulators [Transcription]; Region: PurR; COG1609 208596004925 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 208596004926 DNA binding site [nucleotide binding] 208596004927 domain linker motif; other site 208596004928 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 208596004929 dimerization interface [polypeptide binding]; other site 208596004930 ligand binding site [chemical binding]; other site 208596004931 RibD C-terminal domain; Region: RibD_C; cl17279 208596004932 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 208596004933 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 208596004934 dimer interface [polypeptide binding]; other site 208596004935 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 208596004936 dimer interface [polypeptide binding]; other site 208596004937 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 208596004938 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 208596004939 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208596004940 homodimer interface [polypeptide binding]; other site 208596004941 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 208596004942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208596004943 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 208596004944 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 208596004945 putative active site [active] 208596004946 metal binding site [ion binding]; metal-binding site 208596004947 ComK protein; Region: ComK; cl11560 208596004948 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 208596004949 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208596004950 Homeodomain-like domain; Region: HTH_23; pfam13384 208596004951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596004952 non-specific DNA binding site [nucleotide binding]; other site 208596004953 salt bridge; other site 208596004954 sequence-specific DNA binding site [nucleotide binding]; other site 208596004955 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 208596004956 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596004957 Walker A/P-loop; other site 208596004958 ATP binding site [chemical binding]; other site 208596004959 Q-loop/lid; other site 208596004960 ABC transporter signature motif; other site 208596004961 Walker B; other site 208596004962 D-loop; other site 208596004963 H-loop/switch region; other site 208596004964 ABC-2 type transporter; Region: ABC2_membrane; cl17235 208596004965 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 208596004966 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 208596004967 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 208596004968 Malic enzyme, N-terminal domain; Region: malic; pfam00390 208596004969 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 208596004970 putative NAD(P) binding site [chemical binding]; other site 208596004971 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 208596004972 putative active site pocket [active] 208596004973 dimerization interface [polypeptide binding]; other site 208596004974 putative catalytic residue [active] 208596004975 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 208596004976 putative substrate binding pocket [chemical binding]; other site 208596004977 AC domain interface; other site 208596004978 catalytic triad [active] 208596004979 AB domain interface; other site 208596004980 interchain disulfide; other site 208596004981 Predicted membrane protein [Function unknown]; Region: COG3817 208596004982 Protein of unknown function (DUF979); Region: DUF979; pfam06166 208596004983 Protein of unknown function (DUF969); Region: DUF969; pfam06149 208596004984 Nuclease-related domain; Region: NERD; pfam08378 208596004985 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 208596004986 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 208596004987 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 208596004988 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 208596004989 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 208596004990 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 208596004991 active site turn [active] 208596004992 phosphorylation site [posttranslational modification] 208596004993 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 208596004994 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 208596004995 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 208596004996 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 208596004997 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 208596004998 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 208596004999 substrate binding site [chemical binding]; other site 208596005000 hexamer interface [polypeptide binding]; other site 208596005001 metal binding site [ion binding]; metal-binding site 208596005002 Transcriptional regulators [Transcription]; Region: PurR; COG1609 208596005003 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 208596005004 DNA binding site [nucleotide binding] 208596005005 domain linker motif; other site 208596005006 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 208596005007 dimerization interface [polypeptide binding]; other site 208596005008 ligand binding site [chemical binding]; other site 208596005009 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 208596005010 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 208596005011 substrate binding site [chemical binding]; other site 208596005012 ATP binding site [chemical binding]; other site 208596005013 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 208596005014 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 208596005015 active site 208596005016 intersubunit interface [polypeptide binding]; other site 208596005017 catalytic residue [active] 208596005018 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 208596005019 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 208596005020 active site turn [active] 208596005021 phosphorylation site [posttranslational modification] 208596005022 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 208596005023 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 208596005024 HPr interaction site; other site 208596005025 glycerol kinase (GK) interaction site [polypeptide binding]; other site 208596005026 active site 208596005027 phosphorylation site [posttranslational modification] 208596005028 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 208596005029 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 208596005030 metal binding site [ion binding]; metal-binding site 208596005031 substrate binding pocket [chemical binding]; other site 208596005032 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 208596005033 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208596005034 DNA-binding site [nucleotide binding]; DNA binding site 208596005035 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 208596005036 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 208596005037 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 208596005038 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 208596005039 putative active site [active] 208596005040 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 208596005041 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 208596005042 methionine cluster; other site 208596005043 active site 208596005044 phosphorylation site [posttranslational modification] 208596005045 metal binding site [ion binding]; metal-binding site 208596005046 Uncharacterized conserved protein [Function unknown]; Region: COG3589 208596005047 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 208596005048 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596005049 Coenzyme A binding pocket [chemical binding]; other site 208596005050 Sterol carrier protein domain; Region: SCP2_2; pfam13530 208596005051 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 208596005052 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 208596005053 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 208596005054 active site 208596005055 P-loop; other site 208596005056 phosphorylation site [posttranslational modification] 208596005057 Nuclease-related domain; Region: NERD; pfam08378 208596005058 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 208596005059 active site 208596005060 catalytic triad [active] 208596005061 oxyanion hole [active] 208596005062 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 208596005063 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 208596005064 amphipathic channel; other site 208596005065 Asn-Pro-Ala signature motifs; other site 208596005066 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 208596005067 glycerol kinase; Provisional; Region: glpK; PRK00047 208596005068 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 208596005069 N- and C-terminal domain interface [polypeptide binding]; other site 208596005070 active site 208596005071 MgATP binding site [chemical binding]; other site 208596005072 catalytic site [active] 208596005073 metal binding site [ion binding]; metal-binding site 208596005074 glycerol binding site [chemical binding]; other site 208596005075 homotetramer interface [polypeptide binding]; other site 208596005076 homodimer interface [polypeptide binding]; other site 208596005077 FBP binding site [chemical binding]; other site 208596005078 protein IIAGlc interface [polypeptide binding]; other site 208596005079 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 208596005080 active site 208596005081 catalytic site [active] 208596005082 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 208596005083 Collagen binding domain; Region: Collagen_bind; pfam05737 208596005084 Collagen binding domain; Region: Collagen_bind; pfam05737 208596005085 Collagen binding domain; Region: Collagen_bind; pfam05737 208596005086 Collagen binding domain; Region: Collagen_bind; pfam05737 208596005087 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 208596005088 domain interaction interfaces [polypeptide binding]; other site 208596005089 T surface-antigen of pili; Region: FctA; pfam12892 208596005090 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 208596005091 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 208596005092 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 208596005093 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 208596005094 T surface-antigen of pili; Region: FctA; pfam12892 208596005095 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 208596005096 T surface-antigen of pili; Region: FctA; pfam12892 208596005097 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 208596005098 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 208596005099 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 208596005100 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 208596005101 T surface-antigen of pili; Region: FctA; cl16948 208596005102 Mga helix-turn-helix domain; Region: Mga; pfam05043 208596005103 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 208596005104 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 208596005105 active site 208596005106 P-loop; other site 208596005107 phosphorylation site [posttranslational modification] 208596005108 Mga helix-turn-helix domain; Region: Mga; pfam05043 208596005109 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 208596005110 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 208596005111 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208596005112 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 208596005113 putative translaldolase; Provisional; Region: PRK12376 208596005114 catalytic residue [active] 208596005115 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 208596005116 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 208596005117 active site 208596005118 P-loop; other site 208596005119 phosphorylation site [posttranslational modification] 208596005120 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 208596005121 PRD domain; Region: PRD; pfam00874 208596005122 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 208596005123 active site 208596005124 P-loop; other site 208596005125 phosphorylation site [posttranslational modification] 208596005126 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 208596005127 active site 208596005128 phosphorylation site [posttranslational modification] 208596005129 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 208596005130 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 208596005131 putative mutase; Provisional; Region: PRK12383 208596005132 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 208596005133 dimer interface [polypeptide binding]; other site 208596005134 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 208596005135 active site 208596005136 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 208596005137 substrate binding site [chemical binding]; other site 208596005138 catalytic residue [active] 208596005139 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 208596005140 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 208596005141 active site 208596005142 substrate binding pocket [chemical binding]; other site 208596005143 homodimer interaction site [polypeptide binding]; other site 208596005144 Protein of unknown function; Region: YhfT; pfam10797 208596005145 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 208596005146 Amidase; Region: Amidase; cl11426 208596005147 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 208596005148 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 208596005149 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 208596005150 NADP binding site [chemical binding]; other site 208596005151 active site 208596005152 putative substrate binding site [chemical binding]; other site 208596005153 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 208596005154 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 208596005155 NAD binding site [chemical binding]; other site 208596005156 substrate binding site [chemical binding]; other site 208596005157 homodimer interface [polypeptide binding]; other site 208596005158 active site 208596005159 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 208596005160 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 208596005161 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 208596005162 substrate binding site; other site 208596005163 tetramer interface; other site 208596005164 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 208596005165 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208596005166 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 208596005167 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 208596005168 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 208596005169 active site 208596005170 trimer interface [polypeptide binding]; other site 208596005171 substrate binding site [chemical binding]; other site 208596005172 CoA binding site [chemical binding]; other site 208596005173 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 208596005174 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208596005175 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 208596005176 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208596005177 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 208596005178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208596005179 NAD(P) binding site [chemical binding]; other site 208596005180 active site 208596005181 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 208596005182 Bacterial sugar transferase; Region: Bac_transf; pfam02397 208596005183 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 208596005184 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 208596005185 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 208596005186 Chain length determinant protein; Region: Wzz; cl15801 208596005187 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 208596005188 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 208596005189 active site 208596005190 tetramer interface; other site 208596005191 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 208596005192 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 208596005193 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 208596005194 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 208596005195 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 208596005196 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 208596005197 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596005198 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 208596005199 SH3-like domain; Region: SH3_8; pfam13457 208596005200 SH3-like domain; Region: SH3_8; pfam13457 208596005201 SH3-like domain; Region: SH3_8; pfam13457 208596005202 SH3-like domain; Region: SH3_8; pfam13457 208596005203 SH3-like domain; Region: SH3_8; pfam13457 208596005204 SH3-like domain; Region: SH3_8; pfam13457 208596005205 putative glycosyl transferase; Provisional; Region: PRK10073 208596005206 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 208596005207 active site 208596005208 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208596005209 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 208596005210 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 208596005211 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 208596005212 active site 208596005213 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 208596005214 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 208596005215 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208596005216 putative ADP-binding pocket [chemical binding]; other site 208596005217 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 208596005218 active site 208596005219 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 208596005220 Bacterial sugar transferase; Region: Bac_transf; pfam02397 208596005221 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 208596005222 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 208596005223 active site 208596005224 homodimer interface [polypeptide binding]; other site 208596005225 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 208596005226 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 208596005227 active site 208596005228 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 208596005229 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 208596005230 putative glycosyl transferase; Provisional; Region: PRK10073 208596005231 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 208596005232 active site 208596005233 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 208596005234 UDP-glucose 4-epimerase; Region: PLN02240 208596005235 NAD binding site [chemical binding]; other site 208596005236 homodimer interface [polypeptide binding]; other site 208596005237 active site 208596005238 substrate binding site [chemical binding]; other site 208596005239 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 208596005240 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 208596005241 Acyltransferase family; Region: Acyl_transf_3; pfam01757 208596005242 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 208596005243 active site 208596005244 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 208596005245 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 208596005246 RNA binding surface [nucleotide binding]; other site 208596005247 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 208596005248 active site 208596005249 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 208596005250 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 208596005251 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208596005252 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 208596005253 putative ADP-binding pocket [chemical binding]; other site 208596005254 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 208596005255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208596005256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208596005257 WHG domain; Region: WHG; pfam13305 208596005258 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 208596005259 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 208596005260 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 208596005261 RNA binding site [nucleotide binding]; other site 208596005262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208596005263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208596005264 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 208596005265 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 208596005266 Walker A/P-loop; other site 208596005267 ATP binding site [chemical binding]; other site 208596005268 Q-loop/lid; other site 208596005269 ABC transporter signature motif; other site 208596005270 Walker B; other site 208596005271 D-loop; other site 208596005272 H-loop/switch region; other site 208596005273 Predicted transcriptional regulators [Transcription]; Region: COG1725 208596005274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208596005275 DNA-binding site [nucleotide binding]; DNA binding site 208596005276 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 208596005277 putative hydrophobic ligand binding site [chemical binding]; other site 208596005278 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 208596005279 DEAD-like helicases superfamily; Region: DEXDc; smart00487 208596005280 ATP binding site [chemical binding]; other site 208596005281 putative Mg++ binding site [ion binding]; other site 208596005282 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208596005283 nucleotide binding region [chemical binding]; other site 208596005284 ATP-binding site [chemical binding]; other site 208596005285 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 208596005286 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 208596005287 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 208596005288 Mga helix-turn-helix domain; Region: Mga; pfam05043 208596005289 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208596005290 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 208596005291 active site 208596005292 catalytic tetrad [active] 208596005293 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 208596005294 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 208596005295 putative active site [active] 208596005296 putative metal binding site [ion binding]; other site 208596005297 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 208596005298 Catalytic site [active] 208596005299 putative kinase; Provisional; Region: PRK09954 208596005300 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 208596005301 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 208596005302 substrate binding site [chemical binding]; other site 208596005303 ATP binding site [chemical binding]; other site 208596005304 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 208596005305 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 208596005306 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 208596005307 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 208596005308 Nitrogen regulatory protein P-II; Region: P-II; smart00938 208596005309 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 208596005310 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 208596005311 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 208596005312 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 208596005313 EDD domain protein, DegV family; Region: DegV; TIGR00762 208596005314 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 208596005315 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 208596005316 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 208596005317 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 208596005318 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 208596005319 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 208596005320 Ligand binding site; other site 208596005321 metal-binding site 208596005322 Protein of unknown function (DUF503); Region: DUF503; pfam04456 208596005323 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 208596005324 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 208596005325 RNA binding surface [nucleotide binding]; other site 208596005326 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 208596005327 active site 208596005328 uracil binding [chemical binding]; other site 208596005329 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 208596005330 putative dimer interface [polypeptide binding]; other site 208596005331 catalytic triad [active] 208596005332 Protein of unknown function DUF70; Region: DUF70; cl00785 208596005333 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 208596005334 Predicted transcriptional regulators [Transcription]; Region: COG1695 208596005335 Transcriptional regulator PadR-like family; Region: PadR; cl17335 208596005336 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 208596005337 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 208596005338 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 208596005339 active site 208596005340 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 208596005341 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 208596005342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 208596005343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208596005344 S-adenosylmethionine binding site [chemical binding]; other site 208596005345 putative lipid kinase; Reviewed; Region: PRK13055 208596005346 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 208596005347 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 208596005348 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 208596005349 GatB domain; Region: GatB_Yqey; smart00845 208596005350 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 208596005351 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 208596005352 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 208596005353 esterase; Provisional; Region: PRK10566 208596005354 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 208596005355 CoenzymeA binding site [chemical binding]; other site 208596005356 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 208596005357 subunit interaction site [polypeptide binding]; other site 208596005358 PHB binding site; other site 208596005359 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208596005360 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 208596005361 active site 208596005362 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208596005363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208596005364 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208596005365 dimerization interface [polypeptide binding]; other site 208596005366 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 208596005367 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 208596005368 dimer interface [polypeptide binding]; other site 208596005369 active site 208596005370 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 208596005371 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 208596005372 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 208596005373 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 208596005374 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 208596005375 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208596005376 substrate binding site [chemical binding]; other site 208596005377 oxyanion hole (OAH) forming residues; other site 208596005378 trimer interface [polypeptide binding]; other site 208596005379 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 208596005380 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 208596005381 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 208596005382 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208596005383 acyl-coenzyme A oxidase; Region: PLN02526 208596005384 active site 208596005385 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 208596005386 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 208596005387 acyl-activating enzyme (AAE) consensus motif; other site 208596005388 AMP binding site [chemical binding]; other site 208596005389 active site 208596005390 CoA binding site [chemical binding]; other site 208596005391 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 208596005392 putative dimer interface [polypeptide binding]; other site 208596005393 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 208596005394 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 208596005395 putative dimer interface [polypeptide binding]; other site 208596005396 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 208596005397 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 208596005398 nucleotide binding pocket [chemical binding]; other site 208596005399 K-X-D-G motif; other site 208596005400 catalytic site [active] 208596005401 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 208596005402 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 208596005403 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 208596005404 Dimer interface [polypeptide binding]; other site 208596005405 BRCT sequence motif; other site 208596005406 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 208596005407 Part of AAA domain; Region: AAA_19; pfam13245 208596005408 Family description; Region: UvrD_C_2; pfam13538 208596005409 Transcriptional regulators [Transcription]; Region: FadR; COG2186 208596005410 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208596005411 DNA-binding site [nucleotide binding]; DNA binding site 208596005412 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 208596005413 EamA-like transporter family; Region: EamA; pfam00892 208596005414 EamA-like transporter family; Region: EamA; pfam00892 208596005415 adenylosuccinate lyase; Provisional; Region: PRK07492 208596005416 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 208596005417 tetramer interface [polypeptide binding]; other site 208596005418 active site 208596005419 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 208596005420 ATP-grasp domain; Region: ATP-grasp; pfam02222 208596005421 hypothetical protein; Provisional; Region: PRK04164 208596005422 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 208596005423 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208596005424 active site 208596005425 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 208596005426 Domain of unknown function DUF21; Region: DUF21; pfam01595 208596005427 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 208596005428 Transporter associated domain; Region: CorC_HlyC; pfam03471 208596005429 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 208596005430 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 208596005431 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 208596005432 KDPG and KHG aldolase; Region: Aldolase; cl17259 208596005433 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 208596005434 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 208596005435 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 208596005436 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 208596005437 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 208596005438 dimer interface [polypeptide binding]; other site 208596005439 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 208596005440 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 208596005441 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 208596005442 Predicted secreted protein [Function unknown]; Region: COG4086 208596005443 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 208596005444 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 208596005445 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 208596005446 DXD motif; other site 208596005447 HEAT repeats; Region: HEAT_2; pfam13646 208596005448 PAS domain S-box; Region: sensory_box; TIGR00229 208596005449 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208596005450 putative active site [active] 208596005451 heme pocket [chemical binding]; other site 208596005452 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 208596005453 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208596005454 metal binding site [ion binding]; metal-binding site 208596005455 active site 208596005456 I-site; other site 208596005457 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 208596005458 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 208596005459 Zn2+ binding site [ion binding]; other site 208596005460 Mg2+ binding site [ion binding]; other site 208596005461 FOG: CBS domain [General function prediction only]; Region: COG0517 208596005462 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 208596005463 FOG: CBS domain [General function prediction only]; Region: COG0517 208596005464 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 208596005465 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 208596005466 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 208596005467 Walker A/P-loop; other site 208596005468 ATP binding site [chemical binding]; other site 208596005469 Q-loop/lid; other site 208596005470 ABC transporter signature motif; other site 208596005471 Walker B; other site 208596005472 D-loop; other site 208596005473 H-loop/switch region; other site 208596005474 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 208596005475 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 208596005476 Walker A/P-loop; other site 208596005477 ATP binding site [chemical binding]; other site 208596005478 Q-loop/lid; other site 208596005479 ABC transporter signature motif; other site 208596005480 Walker B; other site 208596005481 D-loop; other site 208596005482 H-loop/switch region; other site 208596005483 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 208596005484 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 208596005485 TM-ABC transporter signature motif; other site 208596005486 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 208596005487 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 208596005488 TM-ABC transporter signature motif; other site 208596005489 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 208596005490 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 208596005491 putative ligand binding site [chemical binding]; other site 208596005492 Predicted membrane protein [Function unknown]; Region: COG4129 208596005493 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 208596005494 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 208596005495 Predicted membrane protein [Function unknown]; Region: COG4129 208596005496 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 208596005497 FtsX-like permease family; Region: FtsX; pfam02687 208596005498 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 208596005499 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 208596005500 FtsX-like permease family; Region: FtsX; pfam02687 208596005501 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 208596005502 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 208596005503 Walker A/P-loop; other site 208596005504 ATP binding site [chemical binding]; other site 208596005505 Q-loop/lid; other site 208596005506 ABC transporter signature motif; other site 208596005507 Walker B; other site 208596005508 D-loop; other site 208596005509 H-loop/switch region; other site 208596005510 amino acid transporter; Region: 2A0306; TIGR00909 208596005511 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 208596005512 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 208596005513 HI0933-like protein; Region: HI0933_like; pfam03486 208596005514 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 208596005515 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 208596005516 Predicted flavoprotein [General function prediction only]; Region: COG0431 208596005517 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 208596005518 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 208596005519 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 208596005520 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 208596005521 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208596005522 putative DNA binding site [nucleotide binding]; other site 208596005523 putative Zn2+ binding site [ion binding]; other site 208596005524 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 208596005525 putative deacylase active site [active] 208596005526 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 208596005527 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 208596005528 putative RNA binding site [nucleotide binding]; other site 208596005529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208596005530 S-adenosylmethionine binding site [chemical binding]; other site 208596005531 VanZ like family; Region: VanZ; pfam04892 208596005532 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 208596005533 Sulfatase; Region: Sulfatase; pfam00884 208596005534 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208596005535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208596005536 dimerization interface [polypeptide binding]; other site 208596005537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208596005538 dimer interface [polypeptide binding]; other site 208596005539 phosphorylation site [posttranslational modification] 208596005540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208596005541 ATP binding site [chemical binding]; other site 208596005542 G-X-G motif; other site 208596005543 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208596005544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208596005545 active site 208596005546 phosphorylation site [posttranslational modification] 208596005547 intermolecular recognition site; other site 208596005548 dimerization interface [polypeptide binding]; other site 208596005549 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208596005550 DNA binding site [nucleotide binding] 208596005551 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 208596005552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 208596005553 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 208596005554 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 208596005555 dimer interface [polypeptide binding]; other site 208596005556 ssDNA binding site [nucleotide binding]; other site 208596005557 tetramer (dimer of dimers) interface [polypeptide binding]; other site 208596005558 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 208596005559 rod shape-determining protein Mbl; Provisional; Region: PRK13928 208596005560 MreB and similar proteins; Region: MreB_like; cd10225 208596005561 nucleotide binding site [chemical binding]; other site 208596005562 Mg binding site [ion binding]; other site 208596005563 putative protofilament interaction site [polypeptide binding]; other site 208596005564 RodZ interaction site [polypeptide binding]; other site 208596005565 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 208596005566 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 208596005567 hinge; other site 208596005568 active site 208596005569 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 208596005570 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 208596005571 gamma subunit interface [polypeptide binding]; other site 208596005572 epsilon subunit interface [polypeptide binding]; other site 208596005573 LBP interface [polypeptide binding]; other site 208596005574 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 208596005575 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 208596005576 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 208596005577 alpha subunit interaction interface [polypeptide binding]; other site 208596005578 Walker A motif; other site 208596005579 ATP binding site [chemical binding]; other site 208596005580 Walker B motif; other site 208596005581 inhibitor binding site; inhibition site 208596005582 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 208596005583 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 208596005584 core domain interface [polypeptide binding]; other site 208596005585 delta subunit interface [polypeptide binding]; other site 208596005586 epsilon subunit interface [polypeptide binding]; other site 208596005587 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 208596005588 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 208596005589 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 208596005590 beta subunit interaction interface [polypeptide binding]; other site 208596005591 Walker A motif; other site 208596005592 ATP binding site [chemical binding]; other site 208596005593 Walker B motif; other site 208596005594 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 208596005595 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 208596005596 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 208596005597 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 208596005598 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 208596005599 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 208596005600 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 208596005601 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 208596005602 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208596005603 active site 208596005604 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 208596005605 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 208596005606 dimer interface [polypeptide binding]; other site 208596005607 active site 208596005608 glycine-pyridoxal phosphate binding site [chemical binding]; other site 208596005609 folate binding site [chemical binding]; other site 208596005610 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 208596005611 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 208596005612 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 208596005613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208596005614 peptide chain release factor 1; Validated; Region: prfA; PRK00591 208596005615 This domain is found in peptide chain release factors; Region: PCRF; smart00937 208596005616 RF-1 domain; Region: RF-1; pfam00472 208596005617 thymidine kinase; Provisional; Region: PRK04296 208596005618 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 208596005619 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 208596005620 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 208596005621 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 208596005622 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 208596005623 catalytic triad [active] 208596005624 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 208596005625 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 208596005626 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 208596005627 Beta-lactamase; Region: Beta-lactamase; pfam00144 208596005628 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 208596005629 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 208596005630 putative metal binding site [ion binding]; other site 208596005631 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 208596005632 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 208596005633 active site 208596005634 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 208596005635 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208596005636 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208596005637 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 208596005638 Walker A/P-loop; other site 208596005639 ATP binding site [chemical binding]; other site 208596005640 Q-loop/lid; other site 208596005641 ABC transporter signature motif; other site 208596005642 Walker B; other site 208596005643 D-loop; other site 208596005644 H-loop/switch region; other site 208596005645 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208596005646 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208596005647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596005648 Walker A/P-loop; other site 208596005649 ATP binding site [chemical binding]; other site 208596005650 Q-loop/lid; other site 208596005651 ABC transporter signature motif; other site 208596005652 Walker B; other site 208596005653 D-loop; other site 208596005654 H-loop/switch region; other site 208596005655 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 208596005656 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 208596005657 Domain of unknown function DUF20; Region: UPF0118; pfam01594 208596005658 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 208596005659 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 208596005660 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 208596005661 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 208596005662 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 208596005663 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 208596005664 Zn binding site [ion binding]; other site 208596005665 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 208596005666 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 208596005667 Zn binding site [ion binding]; other site 208596005668 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 208596005669 Zn binding site [ion binding]; other site 208596005670 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 208596005671 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 208596005672 Zn binding site [ion binding]; other site 208596005673 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 208596005674 Niemann-Pick C type protein family; Region: 2A060601; TIGR00917 208596005675 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 208596005676 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 208596005677 Walker A/P-loop; other site 208596005678 ATP binding site [chemical binding]; other site 208596005679 Q-loop/lid; other site 208596005680 ABC transporter signature motif; other site 208596005681 Walker B; other site 208596005682 D-loop; other site 208596005683 H-loop/switch region; other site 208596005684 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 208596005685 HPr interaction site; other site 208596005686 glycerol kinase (GK) interaction site [polypeptide binding]; other site 208596005687 active site 208596005688 phosphorylation site [posttranslational modification] 208596005689 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 208596005690 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 208596005691 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 208596005692 Predicted membrane protein [Function unknown]; Region: COG2855 208596005693 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 208596005694 aspartate kinase; Reviewed; Region: PRK09034 208596005695 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 208596005696 putative catalytic residues [active] 208596005697 putative nucleotide binding site [chemical binding]; other site 208596005698 putative aspartate binding site [chemical binding]; other site 208596005699 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 208596005700 allosteric regulatory residue; other site 208596005701 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 208596005702 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 208596005703 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 208596005704 peptide binding site [polypeptide binding]; other site 208596005705 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 208596005706 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 208596005707 catalytic residues [active] 208596005708 ZIP Zinc transporter; Region: Zip; pfam02535 208596005709 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 208596005710 Sulfate transporter family; Region: Sulfate_transp; pfam00916 208596005711 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 208596005712 active site 208596005713 homodimer interface [polypeptide binding]; other site 208596005714 catalytic site [active] 208596005715 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 208596005716 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 208596005717 homodimer interface [polypeptide binding]; other site 208596005718 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 208596005719 active site pocket [active] 208596005720 glycogen synthase; Provisional; Region: glgA; PRK00654 208596005721 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 208596005722 ADP-binding pocket [chemical binding]; other site 208596005723 homodimer interface [polypeptide binding]; other site 208596005724 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 208596005725 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 208596005726 oligomer interface; other site 208596005727 ligand binding site; other site 208596005728 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 208596005729 dimer interface [polypeptide binding]; other site 208596005730 N-terminal domain interface [polypeptide binding]; other site 208596005731 sulfate 1 binding site; other site 208596005732 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 208596005733 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 208596005734 ligand binding site; other site 208596005735 oligomer interface; other site 208596005736 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 208596005737 dimer interface [polypeptide binding]; other site 208596005738 N-terminal domain interface [polypeptide binding]; other site 208596005739 sulfate 1 binding site; other site 208596005740 glycogen branching enzyme; Provisional; Region: PRK12313 208596005741 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 208596005742 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 208596005743 active site 208596005744 catalytic site [active] 208596005745 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 208596005746 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 208596005747 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 208596005748 hypothetical protein; Provisional; Region: PRK13665 208596005749 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 208596005750 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 208596005751 Nitrogen regulatory protein P-II; Region: P-II; smart00938 208596005752 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 208596005753 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 208596005754 nucleotide binding site [chemical binding]; other site 208596005755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 208596005756 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 208596005757 Peptidase family M23; Region: Peptidase_M23; pfam01551 208596005758 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 208596005759 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 208596005760 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 208596005761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596005762 motif II; other site 208596005763 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 208596005764 FAD binding domain; Region: FAD_binding_4; pfam01565 208596005765 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 208596005766 tetramer interface [polypeptide binding]; other site 208596005767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208596005768 catalytic residue [active] 208596005769 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 208596005770 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 208596005771 tetramer interface [polypeptide binding]; other site 208596005772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208596005773 catalytic residue [active] 208596005774 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 208596005775 lipoyl attachment site [posttranslational modification]; other site 208596005776 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 208596005777 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 208596005778 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 208596005779 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 208596005780 ArsC family; Region: ArsC; pfam03960 208596005781 putative catalytic residues [active] 208596005782 thiol/disulfide switch; other site 208596005783 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 208596005784 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208596005785 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 208596005786 allantoinase; Provisional; Region: PRK08044 208596005787 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 208596005788 active site 208596005789 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 208596005790 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 208596005791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208596005792 D-galactonate transporter; Region: 2A0114; TIGR00893 208596005793 putative substrate translocation pore; other site 208596005794 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 208596005795 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208596005796 catalytic residue [active] 208596005797 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 208596005798 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 208596005799 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 208596005800 carbamate kinase; Reviewed; Region: PRK12686 208596005801 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 208596005802 putative substrate binding site [chemical binding]; other site 208596005803 nucleotide binding site [chemical binding]; other site 208596005804 nucleotide binding site [chemical binding]; other site 208596005805 homodimer interface [polypeptide binding]; other site 208596005806 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 208596005807 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 208596005808 membrane protein FdrA; Validated; Region: PRK06091 208596005809 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 208596005810 CoA binding domain; Region: CoA_binding; pfam02629 208596005811 CoA-ligase; Region: Ligase_CoA; pfam00549 208596005812 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 208596005813 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 208596005814 Cupin domain; Region: Cupin_2; pfam07883 208596005815 allantoate amidohydrolase; Region: AllC; TIGR03176 208596005816 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 208596005817 active site 208596005818 metal binding site [ion binding]; metal-binding site 208596005819 dimer interface [polypeptide binding]; other site 208596005820 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 208596005821 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 208596005822 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 208596005823 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 208596005824 putative active site [active] 208596005825 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 208596005826 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 208596005827 putative active site cavity [active] 208596005828 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 208596005829 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 208596005830 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 208596005831 active site turn [active] 208596005832 phosphorylation site [posttranslational modification] 208596005833 YrhK-like protein; Region: YrhK; pfam14145 208596005834 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 208596005835 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 208596005836 peptide binding site [polypeptide binding]; other site 208596005837 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 208596005838 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 208596005839 active site 208596005840 dimer interface [polypeptide binding]; other site 208596005841 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 208596005842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208596005843 putative substrate translocation pore; other site 208596005844 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 208596005845 Uncharacterized conserved protein [Function unknown]; Region: COG3379 208596005846 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 208596005847 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 208596005848 dimer interface [polypeptide binding]; other site 208596005849 active site 208596005850 metal binding site [ion binding]; metal-binding site 208596005851 glutathione binding site [chemical binding]; other site 208596005852 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 208596005853 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 208596005854 putative metal binding site [ion binding]; other site 208596005855 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 208596005856 Predicted permeases [General function prediction only]; Region: COG0679 208596005857 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 208596005858 hypothetical protein; Provisional; Region: PRK06770 208596005859 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208596005860 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596005861 non-specific DNA binding site [nucleotide binding]; other site 208596005862 salt bridge; other site 208596005863 sequence-specific DNA binding site [nucleotide binding]; other site 208596005864 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 208596005865 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 208596005866 ring oligomerisation interface [polypeptide binding]; other site 208596005867 ATP/Mg binding site [chemical binding]; other site 208596005868 stacking interactions; other site 208596005869 hinge regions; other site 208596005870 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 208596005871 oligomerisation interface [polypeptide binding]; other site 208596005872 mobile loop; other site 208596005873 roof hairpin; other site 208596005874 CAAX protease self-immunity; Region: Abi; pfam02517 208596005875 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 208596005876 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 208596005877 CoA binding domain; Region: CoA_binding; pfam02629 208596005878 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 208596005879 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 208596005880 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 208596005881 ABC transporter; Region: ABC_tran_2; pfam12848 208596005882 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 208596005883 UGMP family protein; Validated; Region: PRK09604 208596005884 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 208596005885 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 208596005886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596005887 Coenzyme A binding pocket [chemical binding]; other site 208596005888 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 208596005889 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596005890 Coenzyme A binding pocket [chemical binding]; other site 208596005891 Glycoprotease family; Region: Peptidase_M22; pfam00814 208596005892 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 208596005893 CsbD-like; Region: CsbD; pfam05532 208596005894 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 208596005895 extended (e) SDRs; Region: SDR_e; cd08946 208596005896 NAD(P) binding site [chemical binding]; other site 208596005897 active site 208596005898 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 208596005899 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 208596005900 Sulfate transporter family; Region: Sulfate_transp; pfam00916 208596005901 glutathione reductase; Validated; Region: PRK06116 208596005902 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 208596005903 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208596005904 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 208596005905 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 208596005906 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 208596005907 Ligand binding site; other site 208596005908 metal-binding site 208596005909 Chromate transporter; Region: Chromate_transp; pfam02417 208596005910 Chromate transporter; Region: Chromate_transp; pfam02417 208596005911 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 208596005912 MgtC family; Region: MgtC; pfam02308 208596005913 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 208596005914 Predicted membrane protein [Function unknown]; Region: COG2246 208596005915 GtrA-like protein; Region: GtrA; pfam04138 208596005916 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 208596005917 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 208596005918 Ligand binding site; other site 208596005919 Putative Catalytic site; other site 208596005920 DXD motif; other site 208596005921 glucose-1-dehydrogenase; Provisional; Region: PRK08936 208596005922 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 208596005923 NAD binding site [chemical binding]; other site 208596005924 homodimer interface [polypeptide binding]; other site 208596005925 active site 208596005926 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 208596005927 catalytic core [active] 208596005928 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 208596005929 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 208596005930 active site 208596005931 multimer interface [polypeptide binding]; other site 208596005932 T5orf172 domain; Region: T5orf172; pfam10544 208596005933 Predicted transcriptional regulators [Transcription]; Region: COG1733 208596005934 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 208596005935 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 208596005936 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 208596005937 putative active site [active] 208596005938 putative FMN binding site [chemical binding]; other site 208596005939 putative substrate binding site [chemical binding]; other site 208596005940 putative catalytic residue [active] 208596005941 Transcriptional regulators [Transcription]; Region: PurR; COG1609 208596005942 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 208596005943 DNA binding site [nucleotide binding] 208596005944 domain linker motif; other site 208596005945 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 208596005946 putative dimerization interface [polypeptide binding]; other site 208596005947 putative ligand binding site [chemical binding]; other site 208596005948 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 208596005949 active site 208596005950 catalytic residues [active] 208596005951 beta-phosphoglucomutase; Region: bPGM; TIGR01990 208596005952 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596005953 motif II; other site 208596005954 maltose phosphorylase; Provisional; Region: PRK13807 208596005955 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 208596005956 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 208596005957 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 208596005958 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 208596005959 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 208596005960 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 208596005961 active site turn [active] 208596005962 phosphorylation site [posttranslational modification] 208596005963 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 208596005964 putative catalytic site [active] 208596005965 putative metal binding site [ion binding]; other site 208596005966 putative phosphate binding site [ion binding]; other site 208596005967 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 208596005968 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 208596005969 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 208596005970 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 208596005971 active site 208596005972 NTP binding site [chemical binding]; other site 208596005973 metal binding triad [ion binding]; metal-binding site 208596005974 antibiotic binding site [chemical binding]; other site 208596005975 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 208596005976 ADP-ribose binding site [chemical binding]; other site 208596005977 GMP synthase; Reviewed; Region: guaA; PRK00074 208596005978 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 208596005979 AMP/PPi binding site [chemical binding]; other site 208596005980 candidate oxyanion hole; other site 208596005981 catalytic triad [active] 208596005982 potential glutamine specificity residues [chemical binding]; other site 208596005983 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 208596005984 ATP Binding subdomain [chemical binding]; other site 208596005985 Dimerization subdomain; other site 208596005986 pantothenate kinase; Provisional; Region: PRK05439 208596005987 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 208596005988 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 208596005989 ATP-binding site [chemical binding]; other site 208596005990 CoA-binding site [chemical binding]; other site 208596005991 Mg2+-binding site [ion binding]; other site 208596005992 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 208596005993 mevalonate kinase; Region: mevalon_kin; TIGR00549 208596005994 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 208596005995 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 208596005996 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 208596005997 diphosphomevalonate decarboxylase; Region: PLN02407 208596005998 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 208596005999 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 208596006000 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 208596006001 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 208596006002 homotetramer interface [polypeptide binding]; other site 208596006003 FMN binding site [chemical binding]; other site 208596006004 homodimer contacts [polypeptide binding]; other site 208596006005 putative active site [active] 208596006006 putative substrate binding site [chemical binding]; other site 208596006007 Predicted acetyltransferase [General function prediction only]; Region: COG3393 208596006008 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 208596006009 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 208596006010 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 208596006011 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 208596006012 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 208596006013 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 208596006014 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 208596006015 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 208596006016 tetramer (dimer of dimers) interface [polypeptide binding]; other site 208596006017 active site 208596006018 dimer interface [polypeptide binding]; other site 208596006019 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 208596006020 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 208596006021 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 208596006022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596006023 dimer interface [polypeptide binding]; other site 208596006024 conserved gate region; other site 208596006025 putative PBP binding loops; other site 208596006026 ABC-ATPase subunit interface; other site 208596006027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596006028 dimer interface [polypeptide binding]; other site 208596006029 conserved gate region; other site 208596006030 putative PBP binding loops; other site 208596006031 ABC-ATPase subunit interface; other site 208596006032 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 208596006033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596006034 Walker A/P-loop; other site 208596006035 ATP binding site [chemical binding]; other site 208596006036 Q-loop/lid; other site 208596006037 ABC transporter signature motif; other site 208596006038 Walker B; other site 208596006039 D-loop; other site 208596006040 H-loop/switch region; other site 208596006041 TOBE domain; Region: TOBE_2; pfam08402 208596006042 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208596006043 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596006044 non-specific DNA binding site [nucleotide binding]; other site 208596006045 salt bridge; other site 208596006046 sequence-specific DNA binding site [nucleotide binding]; other site 208596006047 Cupin domain; Region: Cupin_2; pfam07883 208596006048 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 208596006049 FAD binding domain; Region: FAD_binding_4; pfam01565 208596006050 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 208596006051 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 208596006052 TrkA-N domain; Region: TrkA_N; pfam02254 208596006053 TrkA-C domain; Region: TrkA_C; pfam02080 208596006054 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 208596006055 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 208596006056 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 208596006057 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 208596006058 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 208596006059 active site 208596006060 putative catalytic site [active] 208596006061 DNA binding site [nucleotide binding] 208596006062 putative phosphate binding site [ion binding]; other site 208596006063 metal binding site A [ion binding]; metal-binding site 208596006064 AP binding site [nucleotide binding]; other site 208596006065 metal binding site B [ion binding]; metal-binding site 208596006066 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 208596006067 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 208596006068 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 208596006069 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 208596006070 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596006071 motif II; other site 208596006072 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 208596006073 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 208596006074 active site 208596006075 catalytic site [active] 208596006076 substrate binding site [chemical binding]; other site 208596006077 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208596006078 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208596006079 substrate binding pocket [chemical binding]; other site 208596006080 membrane-bound complex binding site; other site 208596006081 hinge residues; other site 208596006082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596006083 dimer interface [polypeptide binding]; other site 208596006084 conserved gate region; other site 208596006085 putative PBP binding loops; other site 208596006086 ABC-ATPase subunit interface; other site 208596006087 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 208596006088 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 208596006089 Walker A/P-loop; other site 208596006090 ATP binding site [chemical binding]; other site 208596006091 Q-loop/lid; other site 208596006092 ABC transporter signature motif; other site 208596006093 Walker B; other site 208596006094 D-loop; other site 208596006095 H-loop/switch region; other site 208596006096 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 208596006097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596006098 Coenzyme A binding pocket [chemical binding]; other site 208596006099 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 208596006100 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 208596006101 NADH(P)-binding; Region: NAD_binding_10; pfam13460 208596006102 NAD binding site [chemical binding]; other site 208596006103 substrate binding site [chemical binding]; other site 208596006104 putative active site [active] 208596006105 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 208596006106 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 208596006107 ligand binding site [chemical binding]; other site 208596006108 active site 208596006109 UGI interface [polypeptide binding]; other site 208596006110 catalytic site [active] 208596006111 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 208596006112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596006113 active site 208596006114 motif I; other site 208596006115 motif II; other site 208596006116 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 208596006117 YvrJ protein family; Region: YvrJ; pfam12841 208596006118 Tubby C 2; Region: Tub_2; cl02043 208596006119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596006120 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 208596006121 Coenzyme A binding pocket [chemical binding]; other site 208596006122 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208596006123 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208596006124 substrate binding pocket [chemical binding]; other site 208596006125 membrane-bound complex binding site; other site 208596006126 hinge residues; other site 208596006127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596006128 dimer interface [polypeptide binding]; other site 208596006129 conserved gate region; other site 208596006130 putative PBP binding loops; other site 208596006131 ABC-ATPase subunit interface; other site 208596006132 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 208596006133 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 208596006134 Walker A/P-loop; other site 208596006135 ATP binding site [chemical binding]; other site 208596006136 Q-loop/lid; other site 208596006137 ABC transporter signature motif; other site 208596006138 Walker B; other site 208596006139 D-loop; other site 208596006140 H-loop/switch region; other site 208596006141 Predicted membrane protein [Function unknown]; Region: COG1511 208596006142 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 208596006143 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 208596006144 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 208596006145 Rrf2 family protein; Region: rrf2_super; TIGR00738 208596006146 Transcriptional regulator; Region: Rrf2; pfam02082 208596006147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 208596006148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 208596006149 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 208596006150 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 208596006151 active site 208596006152 catalytic site [active] 208596006153 putative DNA binding site [nucleotide binding]; other site 208596006154 GIY-YIG motif/motif A; other site 208596006155 metal binding site [ion binding]; metal-binding site 208596006156 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 208596006157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 208596006158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 208596006159 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 208596006160 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 208596006161 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 208596006162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596006163 dimer interface [polypeptide binding]; other site 208596006164 conserved gate region; other site 208596006165 putative PBP binding loops; other site 208596006166 ABC-ATPase subunit interface; other site 208596006167 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 208596006168 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 208596006169 substrate binding pocket [chemical binding]; other site 208596006170 membrane-bound complex binding site; other site 208596006171 hinge residues; other site 208596006172 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 208596006173 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 208596006174 putative ligand binding site [chemical binding]; other site 208596006175 NAD binding site [chemical binding]; other site 208596006176 catalytic site [active] 208596006177 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 208596006178 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 208596006179 dimerization interface [polypeptide binding]; other site 208596006180 DPS ferroxidase diiron center [ion binding]; other site 208596006181 ion pore; other site 208596006182 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 208596006183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596006184 Walker A/P-loop; other site 208596006185 ATP binding site [chemical binding]; other site 208596006186 Q-loop/lid; other site 208596006187 ABC transporter signature motif; other site 208596006188 Walker B; other site 208596006189 D-loop; other site 208596006190 H-loop/switch region; other site 208596006191 ABC transporter; Region: ABC_tran_2; pfam12848 208596006192 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 208596006193 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 208596006194 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 208596006195 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208596006196 metal binding site [ion binding]; metal-binding site 208596006197 active site 208596006198 I-site; other site 208596006199 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 208596006200 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 208596006201 ATP binding site [chemical binding]; other site 208596006202 Mg++ binding site [ion binding]; other site 208596006203 motif III; other site 208596006204 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208596006205 nucleotide binding region [chemical binding]; other site 208596006206 ATP-binding site [chemical binding]; other site 208596006207 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 208596006208 RNA binding site [nucleotide binding]; other site 208596006209 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 208596006210 active site 208596006211 homotetramer interface [polypeptide binding]; other site 208596006212 homodimer interface [polypeptide binding]; other site 208596006213 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 208596006214 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 208596006215 active site 208596006216 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 208596006217 active site 208596006218 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208596006219 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208596006220 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 208596006221 Walker A/P-loop; other site 208596006222 ATP binding site [chemical binding]; other site 208596006223 Q-loop/lid; other site 208596006224 ABC transporter signature motif; other site 208596006225 Walker B; other site 208596006226 D-loop; other site 208596006227 H-loop/switch region; other site 208596006228 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208596006229 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208596006230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596006231 Walker A/P-loop; other site 208596006232 ATP binding site [chemical binding]; other site 208596006233 Q-loop/lid; other site 208596006234 ABC transporter signature motif; other site 208596006235 Walker B; other site 208596006236 D-loop; other site 208596006237 H-loop/switch region; other site 208596006238 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 208596006239 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 208596006240 Ligand binding site; other site 208596006241 metal-binding site 208596006242 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 208596006243 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 208596006244 Ligand binding site; other site 208596006245 metal-binding site 208596006246 hypothetical protein; Provisional; Region: PRK11479 208596006247 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 208596006248 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 208596006249 Walker A/P-loop; other site 208596006250 ATP binding site [chemical binding]; other site 208596006251 Q-loop/lid; other site 208596006252 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 208596006253 ABC transporter signature motif; other site 208596006254 Walker B; other site 208596006255 D-loop; other site 208596006256 H-loop/switch region; other site 208596006257 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 208596006258 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 208596006259 active site 208596006260 metal binding site [ion binding]; metal-binding site 208596006261 DNA binding site [nucleotide binding] 208596006262 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 208596006263 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 208596006264 active site 208596006265 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 208596006266 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 208596006267 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 208596006268 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 208596006269 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 208596006270 Potassium binding sites [ion binding]; other site 208596006271 Cesium cation binding sites [ion binding]; other site 208596006272 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 208596006273 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 208596006274 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 208596006275 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 208596006276 Walker A/P-loop; other site 208596006277 ATP binding site [chemical binding]; other site 208596006278 Q-loop/lid; other site 208596006279 ABC transporter signature motif; other site 208596006280 Walker B; other site 208596006281 D-loop; other site 208596006282 H-loop/switch region; other site 208596006283 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 208596006284 FtsX-like permease family; Region: FtsX; pfam02687 208596006285 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 208596006286 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 208596006287 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 208596006288 trimer interface [polypeptide binding]; other site 208596006289 active site 208596006290 G bulge; other site 208596006291 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 208596006292 metal-binding site [ion binding] 208596006293 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 208596006294 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 208596006295 metal-binding site [ion binding] 208596006296 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 208596006297 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 208596006298 metal-binding site [ion binding] 208596006299 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 208596006300 Soluble P-type ATPase [General function prediction only]; Region: COG4087 208596006301 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 208596006302 Penicillinase repressor; Region: Pencillinase_R; pfam03965 208596006303 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 208596006304 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 208596006305 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 208596006306 ligand binding site [chemical binding]; other site 208596006307 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 208596006308 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 208596006309 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 208596006310 active site 208596006311 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 208596006312 NAD(P) binding site [chemical binding]; other site 208596006313 catalytic residues [active] 208596006314 phytoene desaturase; Region: crtI_fam; TIGR02734 208596006315 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 208596006316 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 208596006317 active site lid residues [active] 208596006318 substrate binding pocket [chemical binding]; other site 208596006319 catalytic residues [active] 208596006320 substrate-Mg2+ binding site; other site 208596006321 aspartate-rich region 1; other site 208596006322 aspartate-rich region 2; other site 208596006323 phytoene desaturase; Region: crtI_fam; TIGR02734 208596006324 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 208596006325 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 208596006326 MarR family; Region: MarR_2; pfam12802 208596006327 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 208596006328 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 208596006329 Walker A/P-loop; other site 208596006330 ATP binding site [chemical binding]; other site 208596006331 Q-loop/lid; other site 208596006332 ABC transporter signature motif; other site 208596006333 Walker B; other site 208596006334 D-loop; other site 208596006335 H-loop/switch region; other site 208596006336 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 208596006337 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 208596006338 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 208596006339 putative active site [active] 208596006340 putative CoA binding site [chemical binding]; other site 208596006341 nudix motif; other site 208596006342 metal binding site [ion binding]; metal-binding site 208596006343 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 208596006344 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 208596006345 homodimer interface [polypeptide binding]; other site 208596006346 substrate-cofactor binding pocket; other site 208596006347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 208596006348 catalytic residue [active] 208596006349 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 208596006350 Uncharacterized conserved protein [Function unknown]; Region: COG2966 208596006351 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 208596006352 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 208596006353 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 208596006354 N- and C-terminal domain interface [polypeptide binding]; other site 208596006355 active site 208596006356 catalytic site [active] 208596006357 metal binding site [ion binding]; metal-binding site 208596006358 carbohydrate binding site [chemical binding]; other site 208596006359 ATP binding site [chemical binding]; other site 208596006360 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 208596006361 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 208596006362 NAD binding site [chemical binding]; other site 208596006363 sugar binding site [chemical binding]; other site 208596006364 divalent metal binding site [ion binding]; other site 208596006365 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 208596006366 dimer interface [polypeptide binding]; other site 208596006367 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 208596006368 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 208596006369 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 208596006370 active site turn [active] 208596006371 phosphorylation site [posttranslational modification] 208596006372 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 208596006373 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 208596006374 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 208596006375 putative active site [active] 208596006376 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 208596006377 active site 208596006378 catalytic triad [active] 208596006379 oxyanion hole [active] 208596006380 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 208596006381 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 208596006382 5S rRNA interface [nucleotide binding]; other site 208596006383 CTC domain interface [polypeptide binding]; other site 208596006384 L16 interface [polypeptide binding]; other site 208596006385 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 208596006386 homodimer interface [polypeptide binding]; other site 208596006387 catalytic residues [active] 208596006388 NAD binding site [chemical binding]; other site 208596006389 substrate binding pocket [chemical binding]; other site 208596006390 flexible flap; other site 208596006391 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 208596006392 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 208596006393 dimer interface [polypeptide binding]; other site 208596006394 active site 208596006395 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 208596006396 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 208596006397 beta-galactosidase; Region: BGL; TIGR03356 208596006398 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 208596006399 active site 208596006400 methionine cluster; other site 208596006401 phosphorylation site [posttranslational modification] 208596006402 metal binding site [ion binding]; metal-binding site 208596006403 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 208596006404 active site 208596006405 P-loop; other site 208596006406 phosphorylation site [posttranslational modification] 208596006407 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 208596006408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 208596006409 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 208596006410 Walker A motif; other site 208596006411 ATP binding site [chemical binding]; other site 208596006412 Walker B motif; other site 208596006413 arginine finger; other site 208596006414 Transcriptional antiterminator [Transcription]; Region: COG3933 208596006415 PRD domain; Region: PRD; pfam00874 208596006416 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 208596006417 active pocket/dimerization site; other site 208596006418 active site 208596006419 phosphorylation site [posttranslational modification] 208596006420 PRD domain; Region: PRD; pfam00874 208596006421 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 208596006422 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208596006423 DNA-binding site [nucleotide binding]; DNA binding site 208596006424 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 208596006425 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 208596006426 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 208596006427 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 208596006428 beta-galactosidase; Region: BGL; TIGR03356 208596006429 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 208596006430 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 208596006431 active site 208596006432 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 208596006433 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 208596006434 active site 208596006435 P-loop; other site 208596006436 phosphorylation site [posttranslational modification] 208596006437 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 208596006438 PRD domain; Region: PRD; pfam00874 208596006439 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 208596006440 active site 208596006441 P-loop; other site 208596006442 phosphorylation site [posttranslational modification] 208596006443 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 208596006444 active site 208596006445 phosphorylation site [posttranslational modification] 208596006446 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 208596006447 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 208596006448 catalytic residue [active] 208596006449 putative FPP diphosphate binding site; other site 208596006450 putative FPP binding hydrophobic cleft; other site 208596006451 dimer interface [polypeptide binding]; other site 208596006452 putative IPP diphosphate binding site; other site 208596006453 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 208596006454 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 208596006455 substrate binding [chemical binding]; other site 208596006456 active site 208596006457 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 208596006458 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 208596006459 active site turn [active] 208596006460 phosphorylation site [posttranslational modification] 208596006461 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 208596006462 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 208596006463 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 208596006464 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 208596006465 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 208596006466 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 208596006467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596006468 dimer interface [polypeptide binding]; other site 208596006469 conserved gate region; other site 208596006470 putative PBP binding loops; other site 208596006471 ABC-ATPase subunit interface; other site 208596006472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596006473 dimer interface [polypeptide binding]; other site 208596006474 conserved gate region; other site 208596006475 ABC-ATPase subunit interface; other site 208596006476 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 208596006477 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 208596006478 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 208596006479 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 208596006480 DNA binding site [nucleotide binding] 208596006481 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 208596006482 putative dimerization interface [polypeptide binding]; other site 208596006483 putative ligand binding site [chemical binding]; other site 208596006484 Transcriptional regulators [Transcription]; Region: PurR; COG1609 208596006485 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 208596006486 DNA binding site [nucleotide binding] 208596006487 domain linker motif; other site 208596006488 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 208596006489 dimerization interface [polypeptide binding]; other site 208596006490 ligand binding site [chemical binding]; other site 208596006491 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 208596006492 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 208596006493 nucleotide binding site [chemical binding]; other site 208596006494 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 208596006495 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 208596006496 ligand binding site [chemical binding]; other site 208596006497 flexible hinge region; other site 208596006498 putative switch regulator; other site 208596006499 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 208596006500 non-specific DNA interactions [nucleotide binding]; other site 208596006501 DNA binding site [nucleotide binding] 208596006502 sequence specific DNA binding site [nucleotide binding]; other site 208596006503 putative cAMP binding site [chemical binding]; other site 208596006504 carbamate kinase; Reviewed; Region: PRK12686 208596006505 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 208596006506 putative substrate binding site [chemical binding]; other site 208596006507 nucleotide binding site [chemical binding]; other site 208596006508 nucleotide binding site [chemical binding]; other site 208596006509 homodimer interface [polypeptide binding]; other site 208596006510 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 208596006511 ornithine carbamoyltransferase; Validated; Region: PRK02102 208596006512 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 208596006513 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 208596006514 arginine deiminase; Provisional; Region: PRK01388 208596006515 Arginine repressor [Transcription]; Region: ArgR; COG1438 208596006516 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 208596006517 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 208596006518 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 208596006519 MarR family; Region: MarR; pfam01047 208596006520 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 208596006521 hypothetical protein; Validated; Region: PRK00124 208596006522 CHASE3 domain; Region: CHASE3; cl05000 208596006523 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 208596006524 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 208596006525 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208596006526 dimerization interface [polypeptide binding]; other site 208596006527 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208596006528 dimer interface [polypeptide binding]; other site 208596006529 putative CheW interface [polypeptide binding]; other site 208596006530 CHASE3 domain; Region: CHASE3; cl05000 208596006531 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 208596006532 dimerization interface [polypeptide binding]; other site 208596006533 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 208596006534 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208596006535 dimer interface [polypeptide binding]; other site 208596006536 putative CheW interface [polypeptide binding]; other site 208596006537 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 208596006538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596006539 Walker A/P-loop; other site 208596006540 ATP binding site [chemical binding]; other site 208596006541 Q-loop/lid; other site 208596006542 ABC transporter signature motif; other site 208596006543 Walker B; other site 208596006544 D-loop; other site 208596006545 H-loop/switch region; other site 208596006546 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 208596006547 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 208596006548 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 208596006549 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 208596006550 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 208596006551 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 208596006552 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208596006553 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 208596006554 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 208596006555 DNA binding residues [nucleotide binding] 208596006556 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 208596006557 FHIPEP family; Region: FHIPEP; pfam00771 208596006558 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 208596006559 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 208596006560 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 208596006561 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 208596006562 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 208596006563 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 208596006564 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 208596006565 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 208596006566 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 208596006567 ligand binding site [chemical binding]; other site 208596006568 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 208596006569 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 208596006570 Flagellar protein (FlbD); Region: FlbD; pfam06289 208596006571 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 208596006572 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 208596006573 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 208596006574 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 208596006575 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 208596006576 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 208596006577 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 208596006578 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 208596006579 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 208596006580 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 208596006581 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 208596006582 Walker A motif/ATP binding site; other site 208596006583 Walker B motif; other site 208596006584 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 208596006585 Flagellar assembly protein FliH; Region: FliH; pfam02108 208596006586 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 208596006587 FliG C-terminal domain; Region: FliG_C; pfam01706 208596006588 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 208596006589 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 208596006590 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 208596006591 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 208596006592 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12630 208596006593 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 208596006594 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 208596006595 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 208596006596 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 208596006597 Flagellar protein FliS; Region: FliS; cl00654 208596006598 flagellar capping protein; Reviewed; Region: fliD; PRK08032 208596006599 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 208596006600 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 208596006601 FlaG protein; Region: FlaG; pfam03646 208596006602 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 208596006603 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 208596006604 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 208596006605 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 208596006606 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 208596006607 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 208596006608 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 208596006609 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 208596006610 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 208596006611 FlgN protein; Region: FlgN; cl09176 208596006612 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 208596006613 flagellar motor switch protein; Validated; Region: PRK08119 208596006614 CheC-like family; Region: CheC; pfam04509 208596006615 flagellar motor switch protein FliN; Region: fliN; TIGR02480 208596006616 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 208596006617 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 208596006618 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 208596006619 Response regulator receiver domain; Region: Response_reg; pfam00072 208596006620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208596006621 active site 208596006622 phosphorylation site [posttranslational modification] 208596006623 intermolecular recognition site; other site 208596006624 dimerization interface [polypeptide binding]; other site 208596006625 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 208596006626 CheC-like family; Region: CheC; pfam04509 208596006627 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 208596006628 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 208596006629 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 208596006630 putative binding surface; other site 208596006631 active site 208596006632 P2 response regulator binding domain; Region: P2; pfam07194 208596006633 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 208596006634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208596006635 ATP binding site [chemical binding]; other site 208596006636 Mg2+ binding site [ion binding]; other site 208596006637 G-X-G motif; other site 208596006638 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 208596006639 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 208596006640 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 208596006641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208596006642 S-adenosylmethionine binding site [chemical binding]; other site 208596006643 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 208596006644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208596006645 active site 208596006646 phosphorylation site [posttranslational modification] 208596006647 intermolecular recognition site; other site 208596006648 dimerization interface [polypeptide binding]; other site 208596006649 CheB methylesterase; Region: CheB_methylest; pfam01339 208596006650 CheD chemotactic sensory transduction; Region: CheD; cl00810 208596006651 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 208596006652 Cache domain; Region: Cache_1; pfam02743 208596006653 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 208596006654 dimerization interface [polypeptide binding]; other site 208596006655 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 208596006656 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 208596006657 dimer interface [polypeptide binding]; other site 208596006658 putative CheW interface [polypeptide binding]; other site 208596006659 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208596006660 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 208596006661 active site 208596006662 catalytic tetrad [active] 208596006663 Nuclease-related domain; Region: NERD; pfam08378 208596006664 xanthine permease; Region: pbuX; TIGR03173 208596006665 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 208596006666 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 208596006667 putative active site [active] 208596006668 putative FMN binding site [chemical binding]; other site 208596006669 putative substrate binding site [chemical binding]; other site 208596006670 putative catalytic residue [active] 208596006671 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 208596006672 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 208596006673 putative dimer interface [polypeptide binding]; other site 208596006674 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 208596006675 Predicted transcriptional regulators [Transcription]; Region: COG1695 208596006676 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 208596006677 Predicted transcriptional regulators [Transcription]; Region: COG1695 208596006678 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 208596006679 oligoendopeptidase F; Region: pepF; TIGR00181 208596006680 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 208596006681 active site 208596006682 Zn binding site [ion binding]; other site 208596006683 peptidase T; Region: peptidase-T; TIGR01882 208596006684 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 208596006685 metal binding site [ion binding]; metal-binding site 208596006686 dimer interface [polypeptide binding]; other site 208596006687 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 208596006688 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 208596006689 peptide binding site [polypeptide binding]; other site 208596006690 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 208596006691 dimanganese center [ion binding]; other site 208596006692 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 208596006693 Part of AAA domain; Region: AAA_19; pfam13245 208596006694 Family description; Region: UvrD_C_2; pfam13538 208596006695 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 208596006696 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 208596006697 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 208596006698 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 208596006699 NADH(P)-binding; Region: NAD_binding_10; pfam13460 208596006700 NAD binding site [chemical binding]; other site 208596006701 substrate binding site [chemical binding]; other site 208596006702 putative active site [active] 208596006703 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 208596006704 ArsC family; Region: ArsC; pfam03960 208596006705 putative catalytic residues [active] 208596006706 thiol/disulfide switch; other site 208596006707 Alcohol acetyltransferase; Region: AATase; pfam07247 208596006708 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 208596006709 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 208596006710 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 208596006711 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596006712 Coenzyme A binding pocket [chemical binding]; other site 208596006713 Isochorismatase family; Region: Isochorismatase; pfam00857 208596006714 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 208596006715 catalytic triad [active] 208596006716 conserved cis-peptide bond; other site 208596006717 Heat induced stress protein YflT; Region: YflT; pfam11181 208596006718 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 208596006719 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 208596006720 peptide binding site [polypeptide binding]; other site 208596006721 EDD domain protein, DegV family; Region: DegV; TIGR00762 208596006722 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 208596006723 Predicted transcriptional regulator [Transcription]; Region: COG1959 208596006724 Transcriptional regulator; Region: Rrf2; pfam02082 208596006725 Transcriptional regulator; Region: Rrf2; cl17282 208596006726 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 208596006727 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 208596006728 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208596006729 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 208596006730 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 208596006731 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 208596006732 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 208596006733 Walker A/P-loop; other site 208596006734 ATP binding site [chemical binding]; other site 208596006735 Q-loop/lid; other site 208596006736 ABC transporter signature motif; other site 208596006737 Walker B; other site 208596006738 D-loop; other site 208596006739 H-loop/switch region; other site 208596006740 ATP-grasp domain; Region: ATP-grasp_4; cl17255 208596006741 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 208596006742 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 208596006743 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 208596006744 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 208596006745 putative substrate binding site [chemical binding]; other site 208596006746 putative ATP binding site [chemical binding]; other site 208596006747 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 208596006748 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 208596006749 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 208596006750 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 208596006751 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 208596006752 Soluble P-type ATPase [General function prediction only]; Region: COG4087 208596006753 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 208596006754 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 208596006755 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 208596006756 Walker A/P-loop; other site 208596006757 ATP binding site [chemical binding]; other site 208596006758 Q-loop/lid; other site 208596006759 ABC transporter signature motif; other site 208596006760 Walker B; other site 208596006761 D-loop; other site 208596006762 H-loop/switch region; other site 208596006763 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 208596006764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596006765 dimer interface [polypeptide binding]; other site 208596006766 conserved gate region; other site 208596006767 ABC-ATPase subunit interface; other site 208596006768 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 208596006769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596006770 dimer interface [polypeptide binding]; other site 208596006771 conserved gate region; other site 208596006772 ABC-ATPase subunit interface; other site 208596006773 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 208596006774 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 208596006775 active site 208596006776 metal binding site [ion binding]; metal-binding site 208596006777 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 208596006778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208596006779 Major Facilitator Superfamily; Region: MFS_1; pfam07690 208596006780 putative substrate translocation pore; other site 208596006781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208596006782 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 208596006783 putative active site [active] 208596006784 catalytic residue [active] 208596006785 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 208596006786 putative active site [active] 208596006787 putative metal binding site [ion binding]; other site 208596006788 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 208596006789 active site 208596006790 phosphorylation site [posttranslational modification] 208596006791 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 208596006792 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 208596006793 PRD domain; Region: PRD; pfam00874 208596006794 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 208596006795 active site 208596006796 P-loop; other site 208596006797 phosphorylation site [posttranslational modification] 208596006798 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 208596006799 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 208596006800 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 208596006801 active site 208596006802 P-loop; other site 208596006803 phosphorylation site [posttranslational modification] 208596006804 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 208596006805 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 208596006806 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 208596006807 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 208596006808 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 208596006809 putative active site [active] 208596006810 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 208596006811 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 208596006812 classical (c) SDRs; Region: SDR_c; cd05233 208596006813 NAD(P) binding site [chemical binding]; other site 208596006814 active site 208596006815 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 208596006816 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 208596006817 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208596006818 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 208596006819 catalytic residues [active] 208596006820 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 208596006821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 208596006822 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 208596006823 active site 208596006824 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 208596006825 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 208596006826 D-mannonate oxidoreductase; Provisional; Region: PRK08277 208596006827 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 208596006828 putative NAD(P) binding site [chemical binding]; other site 208596006829 active site 208596006830 mannonate dehydratase; Provisional; Region: PRK03906 208596006831 mannonate dehydratase; Region: uxuA; TIGR00695 208596006832 Glucuronate isomerase; Region: UxaC; pfam02614 208596006833 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 208596006834 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 208596006835 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 208596006836 active site 208596006837 intersubunit interface [polypeptide binding]; other site 208596006838 catalytic residue [active] 208596006839 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 208596006840 Transcriptional regulator [Transcription]; Region: IclR; COG1414 208596006841 Bacterial transcriptional regulator; Region: IclR; pfam01614 208596006842 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 208596006843 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 208596006844 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 208596006845 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 208596006846 substrate binding site [chemical binding]; other site 208596006847 ATP binding site [chemical binding]; other site 208596006848 beta-D-glucuronidase; Provisional; Region: PRK10150 208596006849 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 208596006850 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 208596006851 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 208596006852 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208596006853 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208596006854 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208596006855 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 208596006856 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 208596006857 active site 208596006858 putative substrate binding pocket [chemical binding]; other site 208596006859 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 208596006860 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 208596006861 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 208596006862 active site 208596006863 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 208596006864 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 208596006865 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 208596006866 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 208596006867 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596006868 Walker A/P-loop; other site 208596006869 ATP binding site [chemical binding]; other site 208596006870 Q-loop/lid; other site 208596006871 ABC transporter signature motif; other site 208596006872 Walker B; other site 208596006873 D-loop; other site 208596006874 H-loop/switch region; other site 208596006875 TOBE domain; Region: TOBE_2; pfam08402 208596006876 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 208596006877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596006878 dimer interface [polypeptide binding]; other site 208596006879 conserved gate region; other site 208596006880 putative PBP binding loops; other site 208596006881 ABC-ATPase subunit interface; other site 208596006882 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 208596006883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596006884 dimer interface [polypeptide binding]; other site 208596006885 conserved gate region; other site 208596006886 putative PBP binding loops; other site 208596006887 ABC-ATPase subunit interface; other site 208596006888 VIT family; Region: VIT1; pfam01988 208596006889 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 208596006890 active site 208596006891 oxidoreductase; Provisional; Region: PRK07985 208596006892 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 208596006893 NAD binding site [chemical binding]; other site 208596006894 metal binding site [ion binding]; metal-binding site 208596006895 active site 208596006896 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 208596006897 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 208596006898 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 208596006899 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 208596006900 Ligand binding site [chemical binding]; other site 208596006901 Electron transfer flavoprotein domain; Region: ETF; pfam01012 208596006902 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208596006903 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208596006904 active site 208596006905 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 208596006906 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 208596006907 ligand binding site [chemical binding]; other site 208596006908 flexible hinge region; other site 208596006909 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 208596006910 putative switch regulator; other site 208596006911 non-specific DNA interactions [nucleotide binding]; other site 208596006912 DNA binding site [nucleotide binding] 208596006913 sequence specific DNA binding site [nucleotide binding]; other site 208596006914 putative cAMP binding site [chemical binding]; other site 208596006915 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 208596006916 metal-binding site [ion binding] 208596006917 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 208596006918 metal-binding site [ion binding] 208596006919 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 208596006920 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 208596006921 Soluble P-type ATPase [General function prediction only]; Region: COG4087 208596006922 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 208596006923 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 208596006924 ligand binding site [chemical binding]; other site 208596006925 flexible hinge region; other site 208596006926 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 208596006927 putative switch regulator; other site 208596006928 non-specific DNA interactions [nucleotide binding]; other site 208596006929 DNA binding site [nucleotide binding] 208596006930 sequence specific DNA binding site [nucleotide binding]; other site 208596006931 putative cAMP binding site [chemical binding]; other site 208596006932 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 208596006933 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 208596006934 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208596006935 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208596006936 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 208596006937 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 208596006938 putative metal binding site [ion binding]; other site 208596006939 maltose O-acetyltransferase; Provisional; Region: PRK10092 208596006940 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 208596006941 active site 208596006942 substrate binding site [chemical binding]; other site 208596006943 trimer interface [polypeptide binding]; other site 208596006944 CoA binding site [chemical binding]; other site 208596006945 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 208596006946 MFS/sugar transport protein; Region: MFS_2; pfam13347 208596006947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208596006948 putative substrate translocation pore; other site 208596006949 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 208596006950 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 208596006951 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 208596006952 metal binding site [ion binding]; metal-binding site 208596006953 dimer interface [polypeptide binding]; other site 208596006954 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208596006955 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208596006956 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 208596006957 YibE/F-like protein; Region: YibE_F; pfam07907 208596006958 YibE/F-like protein; Region: YibE_F; pfam07907 208596006959 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 208596006960 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208596006961 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 208596006962 Walker A/P-loop; other site 208596006963 ATP binding site [chemical binding]; other site 208596006964 Q-loop/lid; other site 208596006965 ABC transporter signature motif; other site 208596006966 Walker B; other site 208596006967 D-loop; other site 208596006968 H-loop/switch region; other site 208596006969 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 208596006970 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 208596006971 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 208596006972 Walker A/P-loop; other site 208596006973 ATP binding site [chemical binding]; other site 208596006974 Q-loop/lid; other site 208596006975 ABC transporter signature motif; other site 208596006976 Walker B; other site 208596006977 D-loop; other site 208596006978 H-loop/switch region; other site 208596006979 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 208596006980 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 208596006981 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208596006982 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 208596006983 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 208596006984 active site residue [active] 208596006985 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208596006986 putative DNA binding site [nucleotide binding]; other site 208596006987 dimerization interface [polypeptide binding]; other site 208596006988 putative Zn2+ binding site [ion binding]; other site 208596006989 DNA topoisomerase III; Provisional; Region: PRK07726 208596006990 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 208596006991 active site 208596006992 putative interdomain interaction site [polypeptide binding]; other site 208596006993 putative metal-binding site [ion binding]; other site 208596006994 putative nucleotide binding site [chemical binding]; other site 208596006995 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 208596006996 domain I; other site 208596006997 DNA binding groove [nucleotide binding] 208596006998 phosphate binding site [ion binding]; other site 208596006999 domain II; other site 208596007000 domain III; other site 208596007001 nucleotide binding site [chemical binding]; other site 208596007002 catalytic site [active] 208596007003 domain IV; other site 208596007004 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 208596007005 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 208596007006 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 208596007007 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 208596007008 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 208596007009 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 208596007010 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 208596007011 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 208596007012 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 208596007013 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 208596007014 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 208596007015 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 208596007016 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 208596007017 Helix-turn-helix domain; Region: HTH_18; pfam12833 208596007018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208596007019 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 208596007020 putative hydrophobic ligand binding site [chemical binding]; other site 208596007021 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 208596007022 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208596007023 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 208596007024 active site 208596007025 catalytic tetrad [active] 208596007026 MFS/sugar transport protein; Region: MFS_2; pfam13347 208596007027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208596007028 putative substrate translocation pore; other site 208596007029 putative phosphoketolase; Provisional; Region: PRK05261 208596007030 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 208596007031 TPP-binding site; other site 208596007032 XFP C-terminal domain; Region: XFP_C; pfam09363 208596007033 xylose isomerase; Provisional; Region: PRK05474 208596007034 xylose isomerase; Region: xylose_isom_A; TIGR02630 208596007035 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 208596007036 active site 208596007037 catalytic residues [active] 208596007038 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 208596007039 N- and C-terminal domain interface [polypeptide binding]; other site 208596007040 D-xylulose kinase; Region: XylB; TIGR01312 208596007041 active site 208596007042 MgATP binding site [chemical binding]; other site 208596007043 catalytic site [active] 208596007044 metal binding site [ion binding]; metal-binding site 208596007045 xylulose binding site [chemical binding]; other site 208596007046 homodimer interface [polypeptide binding]; other site 208596007047 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 208596007048 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 208596007049 inhibitor binding site; inhibition site 208596007050 active site 208596007051 xylose isomerase; Provisional; Region: PRK05474 208596007052 xylose isomerase; Region: xylose_isom_A; TIGR02630 208596007053 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 208596007054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596007055 dimer interface [polypeptide binding]; other site 208596007056 conserved gate region; other site 208596007057 putative PBP binding loops; other site 208596007058 ABC-ATPase subunit interface; other site 208596007059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596007060 dimer interface [polypeptide binding]; other site 208596007061 conserved gate region; other site 208596007062 putative PBP binding loops; other site 208596007063 ABC-ATPase subunit interface; other site 208596007064 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 208596007065 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 208596007066 MarR family; Region: MarR_2; pfam12802 208596007067 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 208596007068 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 208596007069 nucleotide binding site [chemical binding]; other site 208596007070 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 208596007071 D-serine dehydratase; Provisional; Region: PRK02991 208596007072 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 208596007073 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 208596007074 catalytic residue [active] 208596007075 seryl-tRNA synthetase; Provisional; Region: PRK05431 208596007076 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 208596007077 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 208596007078 dimer interface [polypeptide binding]; other site 208596007079 active site 208596007080 motif 1; other site 208596007081 motif 2; other site 208596007082 motif 3; other site 208596007083 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 208596007084 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 208596007085 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 208596007086 homotrimer interaction site [polypeptide binding]; other site 208596007087 putative active site [active] 208596007088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 208596007089 YheO-like PAS domain; Region: PAS_6; pfam08348 208596007090 HTH domain; Region: HTH_22; pfam13309 208596007091 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 208596007092 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 208596007093 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 208596007094 active site 208596007095 phosphorylation site [posttranslational modification] 208596007096 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 208596007097 active site 208596007098 P-loop; other site 208596007099 phosphorylation site [posttranslational modification] 208596007100 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 208596007101 HTH domain; Region: HTH_11; pfam08279 208596007102 Mga helix-turn-helix domain; Region: Mga; pfam05043 208596007103 PRD domain; Region: PRD; pfam00874 208596007104 PRD domain; Region: PRD; pfam00874 208596007105 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 208596007106 active site 208596007107 P-loop; other site 208596007108 phosphorylation site [posttranslational modification] 208596007109 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 208596007110 active site 208596007111 phosphorylation site [posttranslational modification] 208596007112 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 208596007113 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208596007114 ATP binding site [chemical binding]; other site 208596007115 putative Mg++ binding site [ion binding]; other site 208596007116 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208596007117 nucleotide binding region [chemical binding]; other site 208596007118 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 208596007119 AAA ATPase domain; Region: AAA_16; pfam13191 208596007120 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 208596007121 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 208596007122 YodA lipocalin-like domain; Region: YodA; pfam09223 208596007123 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 208596007124 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 208596007125 intersubunit interface [polypeptide binding]; other site 208596007126 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 208596007127 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 208596007128 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 208596007129 Repair protein; Region: Repair_PSII; pfam04536 208596007130 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 208596007131 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 208596007132 putative substrate binding site [chemical binding]; other site 208596007133 putative ATP binding site [chemical binding]; other site 208596007134 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 208596007135 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 208596007136 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 208596007137 active site 208596007138 dimer interface [polypeptide binding]; other site 208596007139 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 208596007140 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 208596007141 dimer interface [polypeptide binding]; other site 208596007142 active site 208596007143 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 208596007144 putative active site [active] 208596007145 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 208596007146 active pocket/dimerization site; other site 208596007147 active site 208596007148 phosphorylation site [posttranslational modification] 208596007149 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 208596007150 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 208596007151 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 208596007152 active site 208596007153 phosphorylation site [posttranslational modification] 208596007154 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 208596007155 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 208596007156 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208596007157 DNA-binding site [nucleotide binding]; DNA binding site 208596007158 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 208596007159 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 208596007160 galactokinase; Provisional; Region: PRK05322 208596007161 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 208596007162 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 208596007163 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 208596007164 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 208596007165 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 208596007166 NAD binding site [chemical binding]; other site 208596007167 homodimer interface [polypeptide binding]; other site 208596007168 active site 208596007169 substrate binding site [chemical binding]; other site 208596007170 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 208596007171 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 208596007172 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 208596007173 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 208596007174 active site 208596007175 catalytic residues [active] 208596007176 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 208596007177 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 208596007178 DNA binding site [nucleotide binding] 208596007179 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 208596007180 putative ligand binding site [chemical binding]; other site 208596007181 putative dimerization interface [polypeptide binding]; other site 208596007182 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 208596007183 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 208596007184 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 208596007185 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 208596007186 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 208596007187 substrate binding site [chemical binding]; other site 208596007188 oxyanion hole (OAH) forming residues; other site 208596007189 trimer interface [polypeptide binding]; other site 208596007190 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 208596007191 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 208596007192 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 208596007193 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 208596007194 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208596007195 active site 208596007196 putative acyltransferase; Provisional; Region: PRK05790 208596007197 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 208596007198 dimer interface [polypeptide binding]; other site 208596007199 active site 208596007200 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208596007201 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208596007202 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 208596007203 dimerization interface [polypeptide binding]; other site 208596007204 acyl-coenzyme A oxidase; Region: PLN02526 208596007205 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 208596007206 active site 208596007207 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 208596007208 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 208596007209 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 208596007210 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 208596007211 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 208596007212 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 208596007213 Protein of unknown function (DUF975); Region: DUF975; cl10504 208596007214 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 208596007215 Carbon starvation protein CstA; Region: CstA; pfam02554 208596007216 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 208596007217 two-component response regulator; Provisional; Region: PRK14084 208596007218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208596007219 active site 208596007220 phosphorylation site [posttranslational modification] 208596007221 intermolecular recognition site; other site 208596007222 dimerization interface [polypeptide binding]; other site 208596007223 LytTr DNA-binding domain; Region: LytTR; pfam04397 208596007224 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 208596007225 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 208596007226 GAF domain; Region: GAF_3; pfam13492 208596007227 Histidine kinase; Region: His_kinase; pfam06580 208596007228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208596007229 ATP binding site [chemical binding]; other site 208596007230 Mg2+ binding site [ion binding]; other site 208596007231 G-X-G motif; other site 208596007232 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596007233 salt bridge; other site 208596007234 non-specific DNA binding site [nucleotide binding]; other site 208596007235 sequence-specific DNA binding site [nucleotide binding]; other site 208596007236 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 208596007237 Uncharacterized conserved protein [Function unknown]; Region: COG5646 208596007238 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 208596007239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 208596007240 non-specific DNA binding site [nucleotide binding]; other site 208596007241 salt bridge; other site 208596007242 sequence-specific DNA binding site [nucleotide binding]; other site 208596007243 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 208596007244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208596007245 DNA-binding site [nucleotide binding]; DNA binding site 208596007246 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 208596007247 putative dimerization interface [polypeptide binding]; other site 208596007248 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 208596007249 putative ligand binding site [chemical binding]; other site 208596007250 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 208596007251 active site 208596007252 P-loop; other site 208596007253 phosphorylation site [posttranslational modification] 208596007254 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 208596007255 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 208596007256 TM-ABC transporter signature motif; other site 208596007257 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 208596007258 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 208596007259 Walker A/P-loop; other site 208596007260 ATP binding site [chemical binding]; other site 208596007261 Q-loop/lid; other site 208596007262 ABC transporter signature motif; other site 208596007263 Walker B; other site 208596007264 D-loop; other site 208596007265 H-loop/switch region; other site 208596007266 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 208596007267 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 208596007268 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 208596007269 putative ligand binding site [chemical binding]; other site 208596007270 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208596007271 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208596007272 MFS/sugar transport protein; Region: MFS_2; pfam13347 208596007273 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 208596007274 short chain dehydrogenase; Provisional; Region: PRK09291 208596007275 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 208596007276 NADP binding site [chemical binding]; other site 208596007277 active site 208596007278 steroid binding site; other site 208596007279 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 208596007280 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 208596007281 motif I; other site 208596007282 active site 208596007283 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596007284 Coenzyme A binding pocket [chemical binding]; other site 208596007285 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 208596007286 nudix motif; other site 208596007287 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 208596007288 catalytic core [active] 208596007289 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 208596007290 Predicted flavoprotein [General function prediction only]; Region: COG0431 208596007291 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 208596007292 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 208596007293 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 208596007294 Zn binding site [ion binding]; other site 208596007295 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 208596007296 Zn binding site [ion binding]; other site 208596007297 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 208596007298 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 208596007299 Zn binding site [ion binding]; other site 208596007300 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 208596007301 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 208596007302 Zn binding site [ion binding]; other site 208596007303 Predicted esterase [General function prediction only]; Region: COG0400 208596007304 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 208596007305 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 208596007306 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009 208596007307 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 208596007308 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 208596007309 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 208596007310 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 208596007311 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 208596007312 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 208596007313 Substrate-binding site [chemical binding]; other site 208596007314 Substrate specificity [chemical binding]; other site 208596007315 Cupin domain; Region: Cupin_2; cl17218 208596007316 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 208596007317 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208596007318 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 208596007319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208596007320 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 208596007321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 208596007322 NAD(P) binding site [chemical binding]; other site 208596007323 active site 208596007324 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 208596007325 Uncharacterized conserved protein [Function unknown]; Region: COG2461 208596007326 Family of unknown function (DUF438); Region: DUF438; pfam04282 208596007327 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 208596007328 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 208596007329 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 208596007330 nucleotide binding site [chemical binding]; other site 208596007331 Predicted membrane protein [Function unknown]; Region: COG2860 208596007332 UPF0126 domain; Region: UPF0126; pfam03458 208596007333 UPF0126 domain; Region: UPF0126; pfam03458 208596007334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 208596007335 putative active site [active] 208596007336 PAS fold; Region: PAS_3; pfam08447 208596007337 heme pocket [chemical binding]; other site 208596007338 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 208596007339 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 208596007340 metal binding site [ion binding]; metal-binding site 208596007341 active site 208596007342 I-site; other site 208596007343 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 208596007344 active site residue [active] 208596007345 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 208596007346 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 208596007347 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 208596007348 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 208596007349 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 208596007350 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 208596007351 active site 208596007352 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 208596007353 Predicted esterase [General function prediction only]; Region: COG0400 208596007354 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 208596007355 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 208596007356 Zn binding site [ion binding]; other site 208596007357 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 208596007358 AAA domain; Region: AAA_33; pfam13671 208596007359 active site 208596007360 Uncharacterized conserved protein [Function unknown]; Region: COG1284 208596007361 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 208596007362 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 208596007363 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 208596007364 peptidase T-like protein; Region: PepT-like; TIGR01883 208596007365 metal binding site [ion binding]; metal-binding site 208596007366 putative dimer interface [polypeptide binding]; other site 208596007367 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 208596007368 active site 208596007369 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 208596007370 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 208596007371 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 208596007372 putative active site [active] 208596007373 putative ligand binding site [chemical binding]; other site 208596007374 putative NAD(P) binding site [chemical binding]; other site 208596007375 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 208596007376 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 208596007377 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 208596007378 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208596007379 DNA-binding site [nucleotide binding]; DNA binding site 208596007380 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 208596007381 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 208596007382 beta-galactosidase; Region: BGL; TIGR03356 208596007383 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208596007384 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 208596007385 active site 208596007386 catalytic tetrad [active] 208596007387 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 208596007388 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 208596007389 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 208596007390 Class I ribonucleotide reductase; Region: RNR_I; cd01679 208596007391 active site 208596007392 dimer interface [polypeptide binding]; other site 208596007393 catalytic residues [active] 208596007394 effector binding site; other site 208596007395 R2 peptide binding site; other site 208596007396 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 208596007397 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 208596007398 dimer interface [polypeptide binding]; other site 208596007399 putative radical transfer pathway; other site 208596007400 diiron center [ion binding]; other site 208596007401 tyrosyl radical; other site 208596007402 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 208596007403 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 208596007404 dimer interface [polypeptide binding]; other site 208596007405 putative radical transfer pathway; other site 208596007406 diiron center [ion binding]; other site 208596007407 tyrosyl radical; other site 208596007408 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208596007409 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 208596007410 active site 208596007411 catalytic tetrad [active] 208596007412 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 208596007413 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 208596007414 TM-ABC transporter signature motif; other site 208596007415 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 208596007416 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 208596007417 Walker A/P-loop; other site 208596007418 ATP binding site [chemical binding]; other site 208596007419 Q-loop/lid; other site 208596007420 ABC transporter signature motif; other site 208596007421 Walker B; other site 208596007422 D-loop; other site 208596007423 H-loop/switch region; other site 208596007424 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 208596007425 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 208596007426 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 208596007427 ligand binding site [chemical binding]; other site 208596007428 calcium binding site [ion binding]; other site 208596007429 Cache domain; Region: Cache_1; pfam02743 208596007430 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 208596007431 Histidine kinase; Region: His_kinase; pfam06580 208596007432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208596007433 ATP binding site [chemical binding]; other site 208596007434 Mg2+ binding site [ion binding]; other site 208596007435 G-X-G motif; other site 208596007436 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 208596007437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208596007438 active site 208596007439 phosphorylation site [posttranslational modification] 208596007440 intermolecular recognition site; other site 208596007441 dimerization interface [polypeptide binding]; other site 208596007442 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 208596007443 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 208596007444 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596007445 Coenzyme A binding pocket [chemical binding]; other site 208596007446 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 208596007447 MarR family; Region: MarR; pfam01047 208596007448 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 208596007449 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208596007450 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 208596007451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208596007452 putative substrate translocation pore; other site 208596007453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 208596007454 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208596007455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208596007456 active site 208596007457 phosphorylation site [posttranslational modification] 208596007458 intermolecular recognition site; other site 208596007459 dimerization interface [polypeptide binding]; other site 208596007460 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208596007461 DNA binding site [nucleotide binding] 208596007462 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 208596007463 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 208596007464 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 208596007465 Ligand Binding Site [chemical binding]; other site 208596007466 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 208596007467 GAF domain; Region: GAF_3; pfam13492 208596007468 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208596007469 dimer interface [polypeptide binding]; other site 208596007470 phosphorylation site [posttranslational modification] 208596007471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208596007472 ATP binding site [chemical binding]; other site 208596007473 Mg2+ binding site [ion binding]; other site 208596007474 G-X-G motif; other site 208596007475 K+-transporting ATPase, c chain; Region: KdpC; cl00944 208596007476 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 208596007477 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 208596007478 Soluble P-type ATPase [General function prediction only]; Region: COG4087 208596007479 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 208596007480 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 208596007481 prephenate dehydrogenase; Validated; Region: PRK08507 208596007482 Dehydroquinase class II; Region: DHquinase_II; pfam01220 208596007483 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 208596007484 trimer interface [polypeptide binding]; other site 208596007485 active site 208596007486 dimer interface [polypeptide binding]; other site 208596007487 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 208596007488 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 208596007489 ADP binding site [chemical binding]; other site 208596007490 magnesium binding site [ion binding]; other site 208596007491 putative shikimate binding site; other site 208596007492 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 208596007493 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 208596007494 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 208596007495 shikimate binding site; other site 208596007496 NAD(P) binding site [chemical binding]; other site 208596007497 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 208596007498 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 208596007499 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 208596007500 active site 208596007501 dimer interface [polypeptide binding]; other site 208596007502 metal binding site [ion binding]; metal-binding site 208596007503 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 208596007504 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 208596007505 hinge; other site 208596007506 active site 208596007507 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 208596007508 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 208596007509 Tetramer interface [polypeptide binding]; other site 208596007510 active site 208596007511 FMN-binding site [chemical binding]; other site 208596007512 Chorismate mutase type II; Region: CM_2; smart00830 208596007513 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 208596007514 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 208596007515 minor groove reading motif; other site 208596007516 helix-hairpin-helix signature motif; other site 208596007517 substrate binding pocket [chemical binding]; other site 208596007518 active site 208596007519 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 208596007520 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 208596007521 pentamer interface [polypeptide binding]; other site 208596007522 dodecaamer interface [polypeptide binding]; other site 208596007523 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 208596007524 putative homodimer interface [polypeptide binding]; other site 208596007525 putative homotetramer interface [polypeptide binding]; other site 208596007526 putative metal binding site [ion binding]; other site 208596007527 putative homodimer-homodimer interface [polypeptide binding]; other site 208596007528 putative allosteric switch controlling residues; other site 208596007529 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 208596007530 active site residue [active] 208596007531 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 208596007532 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 208596007533 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208596007534 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 208596007535 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 208596007536 active site residue [active] 208596007537 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 208596007538 active site residue [active] 208596007539 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 208596007540 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 208596007541 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 208596007542 Walker A/P-loop; other site 208596007543 ATP binding site [chemical binding]; other site 208596007544 Q-loop/lid; other site 208596007545 ABC transporter signature motif; other site 208596007546 Walker B; other site 208596007547 D-loop; other site 208596007548 H-loop/switch region; other site 208596007549 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 208596007550 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 208596007551 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 208596007552 Soluble P-type ATPase [General function prediction only]; Region: COG4087 208596007553 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 208596007554 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 208596007555 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 208596007556 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 208596007557 putative dimer interface [polypeptide binding]; other site 208596007558 N-terminal domain interface [polypeptide binding]; other site 208596007559 putative substrate binding pocket (H-site) [chemical binding]; other site 208596007560 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 208596007561 Predicted transcriptional regulators [Transcription]; Region: COG1733 208596007562 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 208596007563 dimerization interface [polypeptide binding]; other site 208596007564 putative DNA binding site [nucleotide binding]; other site 208596007565 putative Zn2+ binding site [ion binding]; other site 208596007566 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 208596007567 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 208596007568 NADP binding site [chemical binding]; other site 208596007569 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 208596007570 intersubunit interface [polypeptide binding]; other site 208596007571 active site 208596007572 catalytic residue [active] 208596007573 putative oxidoreductase; Provisional; Region: PRK10206 208596007574 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 208596007575 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 208596007576 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 208596007577 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 208596007578 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 208596007579 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 208596007580 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 208596007581 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 208596007582 putative active site [active] 208596007583 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 208596007584 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 208596007585 substrate binding site [chemical binding]; other site 208596007586 hexamer interface [polypeptide binding]; other site 208596007587 metal binding site [ion binding]; metal-binding site 208596007588 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 208596007589 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 208596007590 active site 208596007591 P-loop; other site 208596007592 phosphorylation site [posttranslational modification] 208596007593 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 208596007594 active site 208596007595 phosphorylation site [posttranslational modification] 208596007596 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 208596007597 active site 208596007598 P-loop; other site 208596007599 phosphorylation site [posttranslational modification] 208596007600 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 208596007601 active site 208596007602 phosphorylation site [posttranslational modification] 208596007603 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 208596007604 HTH domain; Region: HTH_11; pfam08279 208596007605 PRD domain; Region: PRD; pfam00874 208596007606 PRD domain; Region: PRD; pfam00874 208596007607 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 208596007608 active site 208596007609 P-loop; other site 208596007610 phosphorylation site [posttranslational modification] 208596007611 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 208596007612 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 208596007613 active site 208596007614 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 208596007615 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 208596007616 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 208596007617 Enterocin A Immunity; Region: EntA_Immun; pfam08951 208596007618 methionine sulfoxide reductase A; Provisional; Region: PRK14054 208596007619 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 208596007620 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 208596007621 minor groove reading motif; other site 208596007622 helix-hairpin-helix signature motif; other site 208596007623 substrate binding pocket [chemical binding]; other site 208596007624 active site 208596007625 Putative integral membrane protein DUF46; Region: DUF46; cl17511 208596007626 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 208596007627 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 208596007628 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 208596007629 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 208596007630 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 208596007631 prenyltransferase; Provisional; Region: ubiA; PRK13592 208596007632 UbiA prenyltransferase family; Region: UbiA; pfam01040 208596007633 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 208596007634 phosphoenolpyruvate synthase; Validated; Region: PRK06241 208596007635 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 208596007636 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 208596007637 NADH(P)-binding; Region: NAD_binding_10; pfam13460 208596007638 NAD(P) binding site [chemical binding]; other site 208596007639 putative active site [active] 208596007640 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 208596007641 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 208596007642 active site 208596007643 catalytic tetrad [active] 208596007644 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 208596007645 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 208596007646 active site 208596007647 substrate binding site [chemical binding]; other site 208596007648 trimer interface [polypeptide binding]; other site 208596007649 CoA binding site [chemical binding]; other site 208596007650 Transcriptional regulator [Transcription]; Region: LysR; COG0583 208596007651 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 208596007652 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 208596007653 dimerization interface [polypeptide binding]; other site 208596007654 alpha-mannosidase; Provisional; Region: PRK09819 208596007655 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 208596007656 active site 208596007657 metal binding site [ion binding]; metal-binding site 208596007658 catalytic site [active] 208596007659 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 208596007660 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 208596007661 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 208596007662 active site 208596007663 P-loop; other site 208596007664 phosphorylation site [posttranslational modification] 208596007665 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 208596007666 active site 208596007667 phosphorylation site [posttranslational modification] 208596007668 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 208596007669 PRD domain; Region: PRD; pfam00874 208596007670 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 208596007671 active site 208596007672 P-loop; other site 208596007673 phosphorylation site [posttranslational modification] 208596007674 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 208596007675 active site 208596007676 phosphorylation site [posttranslational modification] 208596007677 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 208596007678 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 208596007679 metal binding site [ion binding]; metal-binding site 208596007680 dimer interface [polypeptide binding]; other site 208596007681 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 208596007682 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 208596007683 Walker A/P-loop; other site 208596007684 ATP binding site [chemical binding]; other site 208596007685 Q-loop/lid; other site 208596007686 ABC transporter signature motif; other site 208596007687 Walker B; other site 208596007688 D-loop; other site 208596007689 H-loop/switch region; other site 208596007690 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 208596007691 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 208596007692 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 208596007693 Walker A/P-loop; other site 208596007694 ATP binding site [chemical binding]; other site 208596007695 Q-loop/lid; other site 208596007696 ABC transporter signature motif; other site 208596007697 Walker B; other site 208596007698 D-loop; other site 208596007699 H-loop/switch region; other site 208596007700 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 208596007701 hypothetical protein; Provisional; Region: PRK06446 208596007702 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 208596007703 metal binding site [ion binding]; metal-binding site 208596007704 dimer interface [polypeptide binding]; other site 208596007705 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 208596007706 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 208596007707 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 208596007708 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 208596007709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596007710 dimer interface [polypeptide binding]; other site 208596007711 conserved gate region; other site 208596007712 putative PBP binding loops; other site 208596007713 ABC-ATPase subunit interface; other site 208596007714 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 208596007715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 208596007716 dimer interface [polypeptide binding]; other site 208596007717 conserved gate region; other site 208596007718 putative PBP binding loops; other site 208596007719 ABC-ATPase subunit interface; other site 208596007720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 208596007721 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 208596007722 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 208596007723 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 208596007724 substrate binding pocket [chemical binding]; other site 208596007725 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 208596007726 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 208596007727 NADP binding site [chemical binding]; other site 208596007728 homodimer interface [polypeptide binding]; other site 208596007729 active site 208596007730 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 208596007731 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 208596007732 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 208596007733 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 208596007734 active site 208596007735 intersubunit interface [polypeptide binding]; other site 208596007736 catalytic residue [active] 208596007737 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 208596007738 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 208596007739 substrate binding site [chemical binding]; other site 208596007740 ATP binding site [chemical binding]; other site 208596007741 Transcriptional regulator [Transcription]; Region: IclR; COG1414 208596007742 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 208596007743 Bacterial transcriptional regulator; Region: IclR; pfam01614 208596007744 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 208596007745 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 208596007746 dimer interface [polypeptide binding]; other site 208596007747 active site 208596007748 metal binding site [ion binding]; metal-binding site 208596007749 Domain of unknown function (DUF718); Region: DUF718; cl01281 208596007750 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 208596007751 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 208596007752 intersubunit interface [polypeptide binding]; other site 208596007753 active site 208596007754 Zn2+ binding site [ion binding]; other site 208596007755 L-rhamnose isomerase; Provisional; Region: PRK01076 208596007756 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 208596007757 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 208596007758 N- and C-terminal domain interface [polypeptide binding]; other site 208596007759 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 208596007760 active site 208596007761 putative catalytic site [active] 208596007762 metal binding site [ion binding]; metal-binding site 208596007763 ATP binding site [chemical binding]; other site 208596007764 carbohydrate binding site [chemical binding]; other site 208596007765 Cupin domain; Region: Cupin_2; pfam07883 208596007766 Helix-turn-helix domain; Region: HTH_18; pfam12833 208596007767 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 208596007768 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 208596007769 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 208596007770 S-formylglutathione hydrolase; Region: PLN02442 208596007771 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 208596007772 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 208596007773 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 208596007774 substrate binding site [chemical binding]; other site 208596007775 catalytic Zn binding site [ion binding]; other site 208596007776 NAD binding site [chemical binding]; other site 208596007777 structural Zn binding site [ion binding]; other site 208596007778 dimer interface [polypeptide binding]; other site 208596007779 Predicted transcriptional regulators [Transcription]; Region: COG1733 208596007780 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 208596007781 YtxH-like protein; Region: YtxH; pfam12732 208596007782 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 208596007783 L-aspartate oxidase; Provisional; Region: PRK06175 208596007784 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 208596007785 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 208596007786 putative active site [active] 208596007787 putative FMN binding site [chemical binding]; other site 208596007788 putative substrate binding site [chemical binding]; other site 208596007789 putative catalytic residue [active] 208596007790 FMN-binding domain; Region: FMN_bind; cl01081 208596007791 FMN-binding domain; Region: FMN_bind; pfam04205 208596007792 FMN-binding domain; Region: FMN_bind; cl01081 208596007793 PAS domain; Region: PAS_10; pfam13596 208596007794 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 208596007795 ApbE family; Region: ApbE; pfam02424 208596007796 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 208596007797 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 208596007798 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 208596007799 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 208596007800 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 208596007801 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 208596007802 purine monophosphate binding site [chemical binding]; other site 208596007803 dimer interface [polypeptide binding]; other site 208596007804 putative catalytic residues [active] 208596007805 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 208596007806 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 208596007807 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 208596007808 active site 208596007809 substrate binding site [chemical binding]; other site 208596007810 cosubstrate binding site; other site 208596007811 catalytic site [active] 208596007812 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 208596007813 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 208596007814 dimerization interface [polypeptide binding]; other site 208596007815 putative ATP binding site [chemical binding]; other site 208596007816 amidophosphoribosyltransferase; Provisional; Region: PRK07272 208596007817 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 208596007818 active site 208596007819 tetramer interface [polypeptide binding]; other site 208596007820 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 208596007821 active site 208596007822 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 208596007823 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 208596007824 dimerization interface [polypeptide binding]; other site 208596007825 ATP binding site [chemical binding]; other site 208596007826 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 208596007827 dimerization interface [polypeptide binding]; other site 208596007828 ATP binding site [chemical binding]; other site 208596007829 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 208596007830 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 208596007831 putative active site [active] 208596007832 catalytic triad [active] 208596007833 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 208596007834 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 208596007835 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 208596007836 ATP binding site [chemical binding]; other site 208596007837 active site 208596007838 substrate binding site [chemical binding]; other site 208596007839 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 208596007840 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 208596007841 ATP-grasp domain; Region: ATP-grasp; pfam02222 208596007842 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 208596007843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 208596007844 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 208596007845 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 208596007846 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 208596007847 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 208596007848 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 208596007849 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208596007850 Uncharacterized conserved protein [Function unknown]; Region: COG0398 208596007851 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 208596007852 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 208596007853 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 208596007854 putative ADP-binding pocket [chemical binding]; other site 208596007855 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 208596007856 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 208596007857 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 208596007858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596007859 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 208596007860 Coenzyme A binding pocket [chemical binding]; other site 208596007861 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 208596007862 putative active site [active] 208596007863 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 208596007864 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 208596007865 cofactor binding site; other site 208596007866 DNA binding site [nucleotide binding] 208596007867 substrate interaction site [chemical binding]; other site 208596007868 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 208596007869 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 208596007870 putative active site [active] 208596007871 catalytic site [active] 208596007872 DEAD-like helicases superfamily; Region: DEXDc; smart00487 208596007873 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 208596007874 ATP binding site [chemical binding]; other site 208596007875 putative Mg++ binding site [ion binding]; other site 208596007876 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 208596007877 nucleotide binding region [chemical binding]; other site 208596007878 ATP-binding site [chemical binding]; other site 208596007879 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 208596007880 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 208596007881 23S rRNA interface [nucleotide binding]; other site 208596007882 L3 interface [polypeptide binding]; other site 208596007883 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 208596007884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 208596007885 Coenzyme A binding pocket [chemical binding]; other site 208596007886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 208596007887 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 208596007888 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 208596007889 dimerization interface 3.5A [polypeptide binding]; other site 208596007890 active site 208596007891 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 208596007892 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 208596007893 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 208596007894 Walker A/P-loop; other site 208596007895 ATP binding site [chemical binding]; other site 208596007896 Q-loop/lid; other site 208596007897 ABC transporter signature motif; other site 208596007898 Walker B; other site 208596007899 D-loop; other site 208596007900 H-loop/switch region; other site 208596007901 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 208596007902 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 208596007903 Walker A/P-loop; other site 208596007904 ATP binding site [chemical binding]; other site 208596007905 Q-loop/lid; other site 208596007906 ABC transporter signature motif; other site 208596007907 Walker B; other site 208596007908 D-loop; other site 208596007909 H-loop/switch region; other site 208596007910 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 208596007911 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 208596007912 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 208596007913 alphaNTD homodimer interface [polypeptide binding]; other site 208596007914 alphaNTD - beta interaction site [polypeptide binding]; other site 208596007915 alphaNTD - beta' interaction site [polypeptide binding]; other site 208596007916 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 208596007917 30S ribosomal protein S11; Validated; Region: PRK05309 208596007918 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 208596007919 30S ribosomal protein S13; Region: bact_S13; TIGR03631 208596007920 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 208596007921 rRNA binding site [nucleotide binding]; other site 208596007922 predicted 30S ribosome binding site; other site 208596007923 adenylate kinase; Reviewed; Region: adk; PRK00279 208596007924 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 208596007925 AMP-binding site [chemical binding]; other site 208596007926 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 208596007927 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 208596007928 SecY translocase; Region: SecY; pfam00344 208596007929 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 208596007930 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 208596007931 23S rRNA binding site [nucleotide binding]; other site 208596007932 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 208596007933 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 208596007934 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 208596007935 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 208596007936 5S rRNA interface [nucleotide binding]; other site 208596007937 23S rRNA interface [nucleotide binding]; other site 208596007938 L5 interface [polypeptide binding]; other site 208596007939 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 208596007940 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 208596007941 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 208596007942 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 208596007943 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 208596007944 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 208596007945 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 208596007946 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 208596007947 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 208596007948 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 208596007949 RNA binding site [nucleotide binding]; other site 208596007950 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 208596007951 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 208596007952 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 208596007953 23S rRNA interface [nucleotide binding]; other site 208596007954 putative translocon interaction site; other site 208596007955 signal recognition particle (SRP54) interaction site; other site 208596007956 L23 interface [polypeptide binding]; other site 208596007957 trigger factor interaction site; other site 208596007958 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 208596007959 23S rRNA interface [nucleotide binding]; other site 208596007960 5S rRNA interface [nucleotide binding]; other site 208596007961 putative antibiotic binding site [chemical binding]; other site 208596007962 L25 interface [polypeptide binding]; other site 208596007963 L27 interface [polypeptide binding]; other site 208596007964 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 208596007965 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 208596007966 G-X-X-G motif; other site 208596007967 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 208596007968 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 208596007969 putative translocon binding site; other site 208596007970 protein-rRNA interface [nucleotide binding]; other site 208596007971 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 208596007972 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 208596007973 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 208596007974 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 208596007975 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 208596007976 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 208596007977 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 208596007978 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 208596007979 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 208596007980 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 208596007981 homodimer interface [polypeptide binding]; other site 208596007982 substrate-cofactor binding pocket; other site 208596007983 catalytic residue [active] 208596007984 AAA domain; Region: AAA_33; pfam13671 208596007985 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 208596007986 active site 208596007987 elongation factor Tu; Reviewed; Region: PRK00049 208596007988 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 208596007989 G1 box; other site 208596007990 GEF interaction site [polypeptide binding]; other site 208596007991 GTP/Mg2+ binding site [chemical binding]; other site 208596007992 Switch I region; other site 208596007993 G2 box; other site 208596007994 G3 box; other site 208596007995 Switch II region; other site 208596007996 G4 box; other site 208596007997 G5 box; other site 208596007998 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 208596007999 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 208596008000 Antibiotic Binding Site [chemical binding]; other site 208596008001 elongation factor G; Reviewed; Region: PRK00007 208596008002 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 208596008003 G1 box; other site 208596008004 putative GEF interaction site [polypeptide binding]; other site 208596008005 GTP/Mg2+ binding site [chemical binding]; other site 208596008006 Switch I region; other site 208596008007 G2 box; other site 208596008008 G3 box; other site 208596008009 Switch II region; other site 208596008010 G4 box; other site 208596008011 G5 box; other site 208596008012 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 208596008013 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 208596008014 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 208596008015 30S ribosomal protein S7; Validated; Region: PRK05302 208596008016 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 208596008017 S17 interaction site [polypeptide binding]; other site 208596008018 S8 interaction site; other site 208596008019 16S rRNA interaction site [nucleotide binding]; other site 208596008020 streptomycin interaction site [chemical binding]; other site 208596008021 23S rRNA interaction site [nucleotide binding]; other site 208596008022 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 208596008023 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 208596008024 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 208596008025 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 208596008026 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 208596008027 tetramerization interface [polypeptide binding]; other site 208596008028 NAD(P) binding site [chemical binding]; other site 208596008029 catalytic residues [active] 208596008030 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 208596008031 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 208596008032 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 208596008033 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 208596008034 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 208596008035 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 208596008036 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 208596008037 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 208596008038 DNA binding site [nucleotide binding] 208596008039 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 208596008040 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 208596008041 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 208596008042 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 208596008043 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 208596008044 RPB1 interaction site [polypeptide binding]; other site 208596008045 RPB10 interaction site [polypeptide binding]; other site 208596008046 RPB11 interaction site [polypeptide binding]; other site 208596008047 RPB3 interaction site [polypeptide binding]; other site 208596008048 RPB12 interaction site [polypeptide binding]; other site 208596008049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208596008050 Methyltransferase domain; Region: Methyltransf_31; pfam13847 208596008051 S-adenosylmethionine binding site [chemical binding]; other site 208596008052 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 208596008053 core dimer interface [polypeptide binding]; other site 208596008054 peripheral dimer interface [polypeptide binding]; other site 208596008055 L10 interface [polypeptide binding]; other site 208596008056 L11 interface [polypeptide binding]; other site 208596008057 putative EF-Tu interaction site [polypeptide binding]; other site 208596008058 putative EF-G interaction site [polypeptide binding]; other site 208596008059 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 208596008060 23S rRNA interface [nucleotide binding]; other site 208596008061 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 208596008062 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 208596008063 mRNA/rRNA interface [nucleotide binding]; other site 208596008064 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 208596008065 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 208596008066 23S rRNA interface [nucleotide binding]; other site 208596008067 L7/L12 interface [polypeptide binding]; other site 208596008068 putative thiostrepton binding site; other site 208596008069 L25 interface [polypeptide binding]; other site 208596008070 NRDE protein; Region: NRDE; cl01315 208596008071 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 208596008072 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 208596008073 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 208596008074 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 208596008075 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 208596008076 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 208596008077 putative homodimer interface [polypeptide binding]; other site 208596008078 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 208596008079 heterodimer interface [polypeptide binding]; other site 208596008080 homodimer interface [polypeptide binding]; other site 208596008081 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 208596008082 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 208596008083 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 208596008084 UbiA prenyltransferase family; Region: UbiA; pfam01040 208596008085 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 208596008086 ApbE family; Region: ApbE; pfam02424 208596008087 FMN-binding domain; Region: FMN_bind; cl01081 208596008088 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 208596008089 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 208596008090 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 208596008091 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 208596008092 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 208596008093 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 208596008094 substrate binding pocket [chemical binding]; other site 208596008095 chain length determination region; other site 208596008096 substrate-Mg2+ binding site; other site 208596008097 catalytic residues [active] 208596008098 aspartate-rich region 1; other site 208596008099 active site lid residues [active] 208596008100 aspartate-rich region 2; other site 208596008101 RNA polymerase factor sigma-70; Validated; Region: PRK08295 208596008102 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 208596008103 YacP-like NYN domain; Region: NYN_YacP; pfam05991 208596008104 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 208596008105 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 208596008106 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 208596008107 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 208596008108 active site 208596008109 metal binding site [ion binding]; metal-binding site 208596008110 dimerization interface [polypeptide binding]; other site 208596008111 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 208596008112 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 208596008113 active site 208596008114 HIGH motif; other site 208596008115 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 208596008116 KMSKS motif; other site 208596008117 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 208596008118 tRNA binding surface [nucleotide binding]; other site 208596008119 anticodon binding site; other site 208596008120 serine O-acetyltransferase; Region: cysE; TIGR01172 208596008121 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 208596008122 trimer interface [polypeptide binding]; other site 208596008123 active site 208596008124 substrate binding site [chemical binding]; other site 208596008125 CoA binding site [chemical binding]; other site 208596008126 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 208596008127 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 208596008128 HIGH motif; other site 208596008129 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 208596008130 active site 208596008131 KMSKS motif; other site 208596008132 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 208596008133 homotrimer interaction site [polypeptide binding]; other site 208596008134 zinc binding site [ion binding]; other site 208596008135 CDP-binding sites; other site 208596008136 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 208596008137 substrate binding site; other site 208596008138 dimer interface; other site 208596008139 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 208596008140 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 208596008141 putative active site [active] 208596008142 DNA repair protein RadA; Provisional; Region: PRK11823 208596008143 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 208596008144 Walker A motif/ATP binding site; other site 208596008145 ATP binding site [chemical binding]; other site 208596008146 Walker B motif; other site 208596008147 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 208596008148 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 208596008149 trimer interface [polypeptide binding]; other site 208596008150 active site 208596008151 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 208596008152 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 208596008153 Walker A/P-loop; other site 208596008154 ATP binding site [chemical binding]; other site 208596008155 Q-loop/lid; other site 208596008156 ABC transporter signature motif; other site 208596008157 Walker B; other site 208596008158 D-loop; other site 208596008159 H-loop/switch region; other site 208596008160 TOBE domain; Region: TOBE_2; pfam08402 208596008161 methionine sulfoxide reductase A; Provisional; Region: PRK14054 208596008162 seryl-tRNA synthetase; Provisional; Region: PRK05431 208596008163 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 208596008164 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 208596008165 dimer interface [polypeptide binding]; other site 208596008166 active site 208596008167 motif 1; other site 208596008168 motif 2; other site 208596008169 motif 3; other site 208596008170 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 208596008171 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 208596008172 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 208596008173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208596008174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 208596008175 dimer interface [polypeptide binding]; other site 208596008176 phosphorylation site [posttranslational modification] 208596008177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208596008178 ATP binding site [chemical binding]; other site 208596008179 Mg2+ binding site [ion binding]; other site 208596008180 G-X-G motif; other site 208596008181 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208596008182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208596008183 active site 208596008184 phosphorylation site [posttranslational modification] 208596008185 intermolecular recognition site; other site 208596008186 dimerization interface [polypeptide binding]; other site 208596008187 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208596008188 DNA binding site [nucleotide binding] 208596008189 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 208596008190 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 208596008191 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 208596008192 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 208596008193 active site 208596008194 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 208596008195 GTP-binding protein YchF; Reviewed; Region: PRK09601 208596008196 YchF GTPase; Region: YchF; cd01900 208596008197 G1 box; other site 208596008198 GTP/Mg2+ binding site [chemical binding]; other site 208596008199 Switch I region; other site 208596008200 G2 box; other site 208596008201 Switch II region; other site 208596008202 G3 box; other site 208596008203 G4 box; other site 208596008204 G5 box; other site 208596008205 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 208596008206 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 208596008207 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 208596008208 ParB-like nuclease domain; Region: ParBc; pfam02195 208596008209 KorB domain; Region: KorB; pfam08535 208596008210 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 208596008211 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 208596008212 P-loop; other site 208596008213 Magnesium ion binding site [ion binding]; other site 208596008214 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 208596008215 Magnesium ion binding site [ion binding]; other site 208596008216 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 208596008217 ParB-like nuclease domain; Region: ParBc; pfam02195 208596008218 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 208596008219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 208596008220 S-adenosylmethionine binding site [chemical binding]; other site 208596008221 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 208596008222 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 208596008223 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 208596008224 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 208596008225 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 208596008226 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 208596008227 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 208596008228 trmE is a tRNA modification GTPase; Region: trmE; cd04164 208596008229 G1 box; other site 208596008230 GTP/Mg2+ binding site [chemical binding]; other site 208596008231 Switch I region; other site 208596008232 G2 box; other site 208596008233 Switch II region; other site 208596008234 G3 box; other site 208596008235 G4 box; other site 208596008236 G5 box; other site 208596008237 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 208596008238 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 208596008239 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 208596008240 TraX protein; Region: TraX; pfam05857 208596008241 conjugal transfer protein TrbP; Provisional; Region: PRK13882 208596008242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 208596008243 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 208596008244 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 208596008245 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 208596008246 active site 208596008247 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 208596008248 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 208596008249 DNA-binding site [nucleotide binding]; DNA binding site 208596008250 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 208596008251 UTRA domain; Region: UTRA; pfam07702 208596008252 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 208596008253 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 208596008254 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 208596008255 Ca binding site [ion binding]; other site 208596008256 active site 208596008257 catalytic site [active] 208596008258 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 208596008259 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 208596008260 active site turn [active] 208596008261 phosphorylation site [posttranslational modification] 208596008262 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 208596008263 FtsX-like permease family; Region: FtsX; pfam02687 208596008264 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 208596008265 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 208596008266 Walker A/P-loop; other site 208596008267 ATP binding site [chemical binding]; other site 208596008268 Q-loop/lid; other site 208596008269 ABC transporter signature motif; other site 208596008270 Walker B; other site 208596008271 D-loop; other site 208596008272 H-loop/switch region; other site 208596008273 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 208596008274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 208596008275 ATP binding site [chemical binding]; other site 208596008276 Mg2+ binding site [ion binding]; other site 208596008277 G-X-G motif; other site 208596008278 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 208596008279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 208596008280 active site 208596008281 phosphorylation site [posttranslational modification] 208596008282 intermolecular recognition site; other site 208596008283 dimerization interface [polypeptide binding]; other site 208596008284 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 208596008285 DNA binding site [nucleotide binding] 208596008286 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 208596008287 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 208596008288 G-X-X-G motif; other site 208596008289 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 208596008290 RxxxH motif; other site 208596008291 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 208596008292 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 208596008293 ribonuclease P; Reviewed; Region: rnpA; PRK00499 208596008294 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399