-- dump date 20140619_025024 -- class Genbank::CDS -- table cds_note -- id note YP_903276.1 KEGG: cbu:CBU_0001 chromosomal replication initiator protein DnaA; TIGRFAM: chromosomal replication initiator protein DnaA; PFAM: Chromosomal replication initiator, DnaA C-terminal domain; Chromosomal replication initiator, DnaA; SMART: AAA ATPase YP_903277.1 KEGG: mfa:Mfla_0002 DNA polymerase III, beta subunit; TIGRFAM: DNA polymerase III, beta subunit; PFAM: DNA polymerase III, beta chain YP_903278.1 KEGG: tcx:Tcr_0012 DNA gyrase, B subunit; TIGRFAM: DNA gyrase, B subunit; PFAM: DNA gyrase, subunit B domain protein; ATP-binding region, ATPase domain protein domain protein; TOPRIM domain protein; DNA topoisomerase, type IIA, subunit B, region 2 domain protein; SMART: DNA topoisomerase II YP_903279.1 PFAM: phosphoribulokinase/uridine kinase; KEGG: tbd:Tbd_2447 phosphoribulokinase YP_903280.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_903281.1 TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate dehydrogenase; KEGG: noc:Noc_2822 dihydroorotate dehydrogenase 1 YP_903282.1 TIGRFAM: dethiobiotin synthase; KEGG: tcx:Tcr_0261 dethiobiotin synthase YP_903283.1 PFAM: Glutathione S-transferase, N-terminal domain; KEGG: hch:HCH_05897 glutathione S-transferase YP_903284.1 KEGG: lpf:lpl2631 ubiquinol-cytochrome c reductase cytochrome c1 subunit YP_903285.1 PFAM: Cytochrome b/b6, N-terminal domain; Cytochrome b/b6, C-terminal domain; KEGG: tbd:Tbd_1832 cytochrome b subunit of cytochrome bc1 YP_903286.1 KEGG: noc:Noc_0299 ubiquinol-cytochrome c reductase, iron-sulfur subunit; TIGRFAM: ubiquinol-cytochrome c reductase, iron-sulfur subunit; PFAM: Rieske [2Fe-2S] domain protein YP_903288.1 TIGRFAM: preprotein translocase, SecA subunit; PFAM: helicase domain protein; SEC-C motif domain protein; SecA DEAD domain protein; SecA Wing and Scaffold; SecA preprotein cross-linking region; KEGG: vfi:VF2193 protein translocase subunit SecA YP_903289.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_903290.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_903291.1 TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase / FAD synthetase; KEGG: son:SO3533 riboflavin biosynthesis protein RibF YP_903292.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis YP_903293.1 KEGG: noc:Noc_2702 hypothetical protein YP_903294.1 PFAM: aminotransferase, class I and II; KEGG: hch:HCH_01778 aspartate/tyrosine/aromatic aminotransferase YP_903295.1 PFAM: peptidylprolyl isomerase, FKBP-type; KEGG: tbd:Tbd_2152 peptidyl-prolyl cis-trans isomerase YP_903296.1 KEGG: pha:PSHAa0339 hypothetical protein YP_903297.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_903298.1 PFAM: peptidase M23B; KEGG: pae:PA0667 hypothetical protein YP_903299.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_903300.1 PFAM: phosphatidate cytidylyltransferase; KEGG: cps:CPS_1558 phosphatidate cytidylyltransferase YP_903301.1 KEGG: vvy:VV2553 undecaprenyl pyrophosphate synthase; TIGRFAM: undecaprenyl diphosphate synthase; PFAM: Di-trans-poly-cis-decaprenylcistransferase YP_903302.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_903303.1 KEGG: neu:NE1011 putative transmembrane protein YP_903304.1 converts protoheme IX and farnesyl diphosphate to heme O YP_903306.1 PFAM: cytochrome oxidase assembly; KEGG: noc:Noc_3040 cytochrome oxidase assembly YP_903307.1 KEGG: cvi:CV3790 hypothetical protein YP_903308.1 PFAM: cytochrome c oxidase, subunit II; cytochrome c, class I; cytochrome C oxidase subunit II, transmembrane region; KEGG: pha:PSHAa2872 cytochrome c oxidase, subunit II YP_903309.1 PFAM: cytochrome c oxidase, subunit I; KEGG: pae:PA0106 cytochrome c oxidase, subunit I YP_903310.1 PFAM: cytochrome c oxidase assembly protein CtaG/Cox11; KEGG: mca:MCA0882 cytochrome c oxidase assembly protein, putative YP_903311.1 PFAM: cytochrome c oxidase, subunit III; KEGG: hch:HCH_00049 cytochrome-c oxidase, subnunit III YP_903312.1 KEGG: mca:MCA0131 hypothetical protein YP_903313.1 CcoN; FixN YP_903314.1 CcoO; FixO YP_903315.1 KEGG: tcx:Tcr_1963 cytochrome c oxidase, cbb3-type, subunit III YP_903316.1 PFAM: outer membrane lipoprotein carrier protein LolA; KEGG: pae:PA2614 periplasmic chaperone LolA YP_903317.1 PFAM: cell divisionFtsK/SpoIIIE; KEGG: sde:Sde_1693 cell division protein FtsK YP_903318.1 TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: tcx:Tcr_0763 thioredoxin reductase YP_903319.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_903320.1 PFAM: Holliday junction resolvase YqgF; SMART: Resolvase, RNase H domain protein fold; KEGG: cbu:CBU_2094 putative Holliday junction resolvase YP_903321.1 TIGRFAM: lytic murein transglycosylase; PFAM: Peptidoglycan-binding domain 1 protein; KEGG: sat:SYN_02632 membrane-bound lytic murein transglycosylase B YP_903322.1 PFAM: ApbE family lipoprotein; KEGG: sde:Sde_1803 thiamine biosynthesis lipoprotein YP_903323.1 TIGRFAM: CrcB protein; PFAM: Camphor resistance CrcB protein; KEGG: lpn:lpg0512 CrcB protein, camphor resistance YP_903324.1 KEGG: tcx:Tcr_1825 glutathione synthetase; TIGRFAM: glutathione synthetase; PFAM: glutathione synthetase domain protein; glutathione synthetase, ATP-binding; RimK domain protein ATP-grasp YP_903325.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_903326.1 KEGG: mca:MCA1316 N utilization substance protein A; TIGRFAM: transcription termination factor NusA; PFAM: RNA binding S1 domain protein; KH, type 1, domain protein; NusA N-terminal domain protein; SMART: KH domain protein YP_903327.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_903328.1 PFAM: ribosome-binding factor A; KEGG: lpp:lpp2819 ribosome-binding factor A YP_903329.1 KEGG: pmu:PM0756 tRNA pseudouridine 55 synthase; TIGRFAM: tRNA pseudouridine synthase B; PFAM: pseudouridylate synthase TruB domain protein YP_903330.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_903331.1 KEGG: neu:NE1008 hypothetical protein YP_903332.1 TIGRFAM: Protein of unknown function UPF0011; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: aci:ACIAD1130 putative methyltransferase YP_903333.1 KEGG: cbu:CBU_0152 dephospho-CoA kinase; TIGRFAM: dephospho-CoA kinase; PFAM: Dephospho-CoA kinase YP_903334.1 KEGG: tcx:Tcr_0244 transketolase; TIGRFAM: transketolase; PFAM: Transketolase domain protein; Transketolase, central region YP_903335.1 TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; KEGG: tbd:Tbd_0160 glyceraldehyde-3-phosphate dehydrogenase, type I YP_903336.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_903337.1 PFAM: pyruvate kinase; KEGG: vpa:VP2039 pyruvate kinase II YP_903338.1 KEGG: noc:Noc_2804 fructose-bisphosphate aldolase, class II, calvin cycle subtype; TIGRFAM: ketose-bisphosphate aldolases; fructose-bisphosphate aldolase, class II, Calvin cycle subtype; PFAM: ketose-bisphosphate aldolase, class-II YP_903339.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_903340.1 TIGRFAM: methyltransferase GidB; PFAM: glucose inhibited division protein; KEGG: mfa:Mfla_2754 methyltransferase GidB YP_903341.1 KEGG: sde:Sde_1913 hypothetical protein YP_903342.1 TIGRFAM: hydrolase, TatD family; PFAM: TatD-related deoxyribonuclease; KEGG: rso:RSc1787 putative deoxyribonuclease YP_903343.1 TIGRFAM: pseudouridine synthase, RluA family; PFAM: RNA-binding S4 domain protein; pseudouridine synthase; KEGG: pmu:PM0992 ribosomal large subunit pseudouridine synthase C YP_903344.1 TIGRFAM: 4-hydroxybenzoate polyprenyl transferase; PFAM: UbiA prenyltransferase; KEGG: vch:VC0094 4-hydroxybenzoate octaprenyltransferase YP_903345.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_903346.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: tcx:Tcr_1962 4Fe-4S ferredoxin, iron-sulfur binding YP_903347.1 KEGG: tcx:Tcr_1961 hypothetical protein YP_903348.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: vfi:VF0829 high-affinity zinc uptake system ATP-binding protein ZnuC YP_903349.1 KEGG: hch:HCH_06350 DNA polymerase I; TIGRFAM: DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease; 3'-5' exonuclease; SMART: Helix-hairpin-helix domain protein, class 2 YP_903350.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_903351.1 PFAM: UvrD/REP helicase; KEGG: cbu:CBU_1230 UvrD/REP helicase family protein YP_903352.1 PFAM: thiamine monophosphate synthase; KEGG: cvi:CV0150 probable thiamine-phosphate diphosphorylase YP_903353.1 PFAM: protein of unknown function DUF1239 YP_903354.1 PFAM: OstA family protein; KEGG: noc:Noc_2791 OstA-like protein YP_903355.1 ATP sulfurylase; ATPS; converts ATP and sulfate to 5'phosphosulfate and pyrophosphate; in some organisms this enzyme is involved in the incorporation of inorganic sulfate while in others it is involved in the production of ATP in the reverse direction; the enzyme from Thermus thermophilus is dimeric and binds a zinc ion that is coordinated by cysteine and histidine residues that are not found in all related proteins but is found in some thermophilic organisms YP_903356.1 KEGG: tbd:Tbd_2284 hypothetical protein YP_903357.1 TIGRFAM: adenylylsulfate reductase, beta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: tbd:Tbd_2283 adenylylsulfate reductase, beta subunit YP_903358.1 catalyzes the reduction of adenosine 5'-phosphosulfate to AMP and sulfite YP_903359.1 KEGG: tbd:Tbd_2281 hypothetical protein YP_903360.1 KEGG: tbd:Tbd_2280 putative peptidyl-prolyl cis-trans isomerase YP_903361.1 KEGG: tbd:Tbd_1503 hypothetical protein YP_903362.1 pyrophosphate-energized proton pump; pyrophosphate-energized inorganic pyrophosphatase; H+-PPase; can cleave pyrophosphate to two phosphates; can generate a proton motive force and drive pyrophosphate synthesis when PMF is sufficient YP_903363.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_903364.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_903365.1 KEGG: sdn:Sden_3728 cadherin YP_903366.1 KEGG: mca:MCA0509 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: cysteinyl-tRNA synthetase, class Ia YP_903367.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein; KEGG: tcx:Tcr_1387 alkyl hydroperoxide reductase/thiol specific antioxidant/Mal allergen YP_903368.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_903369.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_903370.1 TIGRFAM: diaminopimelate decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: tcx:Tcr_1847 diaminopimelate decarboxylase YP_903371.1 PFAM: protein of unknown function UPF0044; KEGG: pmu:PM0713 putative RNA-binding protein containing KH domain YP_903372.1 KEGG: sde:Sde_2584 lipid-A-disaccharide synthase; TIGRFAM: lipid-A-disaccharide synthase; PFAM: glycosyl transferase, family 19 YP_903373.1 KEGG: cbu:CBU_0098 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase YP_903374.1 PFAM: inositol monophosphatase; KEGG: noc:Noc_2419 3(2),5 -bisphosphate nucleotidase YP_903375.1 TIGRFAM: RNA polymerase sigma factor RpoD; PFAM: sigma-70 1.1 domain protein; sigma-70 region 3 domain protein; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; sigma-70, non-essential domain protein; sigma-70 region 1.2; KEGG: xfa:XF1350 RNA polymerase sigma-70 factor YP_903376.1 KEGG: tbd:Tbd_0387 ribose-phosphate pyrophosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase YP_903377.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_903378.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_903379.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_903380.1 PFAM: peptidase M24; peptidase M24B, X-Pro dipeptidase/aminopeptidase domain protein; KEGG: aci:ACIAD1126 aminopeptidase P YP_903382.1 KEGG: tbd:Tbd_2558 hypothetical protein YP_903383.1 KEGG: tcx:Tcr_1837 pyrroline-5-carboxylate reductase; TIGRFAM: pyrroline-5-carboxylate reductase; PFAM: NADP oxidoreductase, coenzyme F420-dependent; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein YP_903384.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_903385.1 TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: hin:HI1554 adenosylmethionine--8-amino-7-oxononanoate transaminase YP_903386.1 TIGRFAM: primosomal protein N'; PFAM: helicase domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; KEGG: cbu:CBU_1815 primosomal protein N' YP_903387.1 PFAM: protein of unknown function UPF0054; KEGG: pae:PA3982 conserved hypothetical protein YP_903388.1 TIGRFAM: tRNA(Ile)-lysidine synthetase; tRNA(Ile)-lysidine synthetase-like; PFAM: PP-loop domain protein; KEGG: cbu:CBU_1509 mesJ protein YP_903389.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_903390.1 PFAM: protein of unknown function DUF47; KEGG: pae:PA5208 hypothetical protein YP_903391.1 PFAM: phosphate transporter; KEGG: csa:Csal_0712 phosphate transporter YP_903392.1 PFAM: BolA family protein; KEGG: mca:MCA0260 toluene-tolerance protein, putative YP_903393.1 PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; KEGG: tcx:Tcr_0779 DEAD/DEAH box helicase-like YP_903394.1 KEGG: gme:Gmet_2337 hypothetical protein YP_903395.1 PFAM: membrane bound O-acyl transferase, MBOAT family protein; KEGG: bcz:BCZK0793 alginate O-acetyltransferase YP_903397.1 TIGRFAM: tyrosyl-tRNA synthetase; PFAM: aminoacyl-tRNA synthetase, class Ib; RNA-binding S4 domain protein; KEGG: ftl:FTL_0968 tyrosyl-tRNA synthetase YP_903398.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_903399.1 KEGG: pfl:PFL_5441 DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta YP_903401.1 KEGG: mca:MCA1848 cell division protein FtsH; TIGRFAM: ATP-dependent metalloprotease FtsH; PFAM: peptidase M41; AAA ATPase, central domain protein; peptidase M41, FtsH extracellular; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_903402.1 KEGG: cps:CPS_3451 dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase, DHPS YP_903403.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_903404.1 TIGRFAM: electron transport complex, RnfABCDGE type, A subunit; PFAM: RnfA-Nqr electron transport subunit; KEGG: noc:Noc_0970 electron transport complex, RnfABCDGE type, A subunit YP_903405.1 TIGRFAM: electron transport complex, RnfABCDGE type, B subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; Fe-S cluster domain protein; KEGG: tbd:Tbd_2016 electron transport complex, RnfABCDGE type, B subunit YP_903406.1 TIGRFAM: electron transport complex, RnfABCDGE type, C subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit; KEGG: noc:Noc_1173 electron transport complex protein RnfC YP_903407.1 TIGRFAM: electron transport complex, RnfABCDGE type, D subunit; PFAM: NQR2 and RnfD family protein; KEGG: eca:ECA2279 electron transport complex protein YP_903408.1 TIGRFAM: electron transport complex, RnfABCDGE type, G subunit; PFAM: FMN-binding domain protein; KEGG: tcx:Tcr_1032 electron transport complex, RnfABCDGE type, G subunit YP_903409.1 KEGG: tcx:Tcr_0902 hypothetical protein YP_903410.1 TIGRFAM: succinyl-CoA synthetase, alpha subunit; PFAM: CoA-binding domain protein; ATP-citrate lyase/succinyl-CoA ligase; KEGG: noc:Noc_0714 succinyl-CoA ligase, alpha subunit YP_903411.1 catalyzes the interconversion of succinyl-CoA and succinate YP_903412.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_903413.1 PFAM: tRNA synthetase, class II (D, K and N); KEGG: cps:CPS_4763 conserved hypothetical protein TIGR00462 YP_903414.1 PFAM: Sel1 domain protein repeat-containing protein; KEGG: lpf:lpl1180 hypothetical protein YP_903415.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_903416.1 TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: aci:ACIAD0342 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (phosphatidylglycerophosphate synthase) (PGP synthase) YP_903417.1 TIGRFAM: UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; PFAM: cytoplasmic peptidoglycan synthetase domain protein; cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG: par:Psyc_2052 probable UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase YP_903418.1 TIGRFAM: UDP-N-acetylmuramyl-tripeptide synthetases; PFAM: cytoplasmic peptidoglycan synthetase domain protein; cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG: lpp:lpp0978 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_903419.1 TIGRFAM: Twin-arginine translocation pathway signal; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: tcx:Tcr_1549 sulfate thiol esterase YP_903420.1 KEGG: jan:Jann_0120 hypothetical protein YP_903421.1 KEGG: noc:Noc_2788 sugar phosphate isomerase involved in capsule formation, KpsF/GutQ; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS) YP_903422.1 PFAM: low molecular weight phosphotyrosine protein phosphatase; KEGG: bbr:BB2274 low molecular weight protein-tyrosine-phosphatase YP_903423.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_903424.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_903425.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_903426.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_903427.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_903428.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_903429.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_903430.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_903431.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_903432.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_903433.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_903434.1 KEGG: pae:PA4257 30S ribosomal protein S3; TIGRFAM: ribosomal protein S3; PFAM: ribosomal protein S3-C-terminal domain protein; KH, type 2 domain protein; Ribosomal protein S3, N-terminal domain; SMART: KH domain protein YP_903435.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_903436.1 one of the stabilizing components for the large ribosomal subunit YP_903437.1 PFAM: ribosomal protein S17; KEGG: ppu:PP0463 ribosomal protein S17 YP_903438.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_903439.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_903440.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_903441.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_903442.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_903443.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_903444.1 binds 5S rRNA along with protein L5 and L25 YP_903445.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_903446.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_903447.1 late assembly protein YP_903448.1 TIGRFAM: preprotein translocase, SecY subunit; PFAM: SecY protein; KEGG: noc:Noc_2305 SecY protein YP_903449.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_903450.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_903451.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_903452.1 PFAM: ribosomal protein S4; RNA-binding S4 domain protein; KEGG: sgl:SG2254 30S ribosomal protein S4 YP_903453.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_903454.1 is a component of the macrolide binding site in the peptidyl transferase center YP_903455.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_903456.1 KEGG: noc:Noc_2728 protein-methionine-S-oxide reductase; TIGRFAM: methionine-R-sulfoxide reductase; PFAM: Methionine sulfoxide reductase B YP_903457.1 PFAM: Polynucleotide adenylyltransferase region; KEGG: cbu:CBU_1827 tRNA nucleotidyltransferase (CCA-adding enzyme) YP_903458.1 KEGG: nmu:Nmul_A0722 hypothetical protein YP_903459.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_903460.1 KEGG: sdn:Sden_1464 cytochrome c, class I YP_903461.1 KEGG: mag:amb3084 cytochrome c4 precursor YP_903462.1 PFAM: cytochrome c, class I; KEGG: ppr:PBPRA3501 putative cytochrome c4 YP_903463.1 TIGRFAM: trigger factor; PFAM: peptidylprolyl isomerase, FKBP-type; trigger factor, C-terminal domain protein; trigger factor, N-terminal domain; KEGG: hch:HCH_02157 trigger factor YP_903464.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_903465.1 binds and unfolds substrates as part of the ClpXP protease YP_903466.1 TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; KEGG: eca:ECA3933 putative GTP-binding phage-related protein YP_903467.1 KEGG: tbd:Tbd_1675 peptidase S16, ATP-dependent protease La; TIGRFAM: ATP-dependent protease La; PFAM: peptidase S16, lon domain protein; AAA ATPase, central domain protein; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_903468.1 TIGRFAM: sun protein; PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; KEGG: hin:HI0624 Sun protein YP_903469.1 KEGG: noc:Noc_2253 thiol-disulfide interchange protein DsbC YP_903470.1 PFAM: peptidase M17, leucyl aminopeptidase domain protein; KEGG: noc:Noc_0289 leucyl aminopeptidase YP_903471.1 KEGG: tcx:Tcr_0450 hypothetical protein YP_903472.1 PFAM: CBS domain containing protein; KEGG: vvy:VV0994 hypothetical protein YP_903473.1 KEGG: vpa:VP0813 putative nitrogen regulatory protein P-II family protein YP_903474.1 PFAM: protein of unknown function DUF1538; KEGG: vpa:VP0812 hypothetical protein YP_903475.1 PFAM: protein of unknown function DUF1538; KEGG: cps:CPS_1953 hypothetical protein YP_903476.1 PFAM: aminotransferase, class IV; KEGG: noc:Noc_1662 aminotransferase, class IV YP_903477.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_903478.1 KEGG: cbu:CBU_0500 DNA polymerase III, delta prime subunit; similar to ATPases involved in DNA replication YP_903479.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_903480.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; KEGG: tcx:Tcr_0999 HAD-superfamily subfamily IB, PSPase-like YP_903481.1 KEGG: tbd:Tbd_0575 hypothetical protein YP_903482.1 PFAM: SirA family protein; KEGG: mag:amb0858 predicted redox protein YP_903483.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_903484.1 TIGRFAM: non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; PFAM: Ham1 family protein; KEGG: vpa:VP2621 Ham1 protein YP_903485.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_903486.1 PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: noc:Noc_0363 dihydroorotate dehydrogenase electron transfer subunit YP_903487.1 TIGRFAM: Protein of unknown function UPF0001; PFAM: alanine racemase domain protein; KEGG: eca:ECA3627 putative alanine racemase YP_903488.1 KEGG: lpp:lpp1719 hypothetical protein YP_903489.1 PFAM: peptidase U62, modulator of DNA gyrase; KEGG: plu:plu4064 tldD protein, suppresses the inhibitory activity of the carbon storage regulator (CSRA) YP_903490.1 PFAM: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; KEGG: tcx:Tcr_0817 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 YP_903491.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_903492.1 KEGG: lpn:lpg2787 NADH dehydrogenase I, C subunit; TIGRFAM: NADH (or F420H2) dehydrogenase, subunit C; PFAM: NADH dehydrogenase (ubiquinone), 30 kDa subunit YP_903493.1 Catalyzes the transfer of electrons from NADH to quinone YP_903494.1 KEGG: tcx:Tcr_0821 NADH-quinone oxidoreductase, E subunit; TIGRFAM: NADH-quinone oxidoreductase, E subunit; PFAM: NADH dehydrogenase (ubiquinone), 24 kDa subunit YP_903495.1 KEGG: lpp:lpp2831 NADH dehydrogenase I chain F; TIGRFAM: NADH-quinone oxidoreductase, F subunit; PFAM: Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit YP_903496.1 TIGRFAM: NADH-quinone oxidoreductase, chain G; PFAM: ferredoxin; molybdopterin oxidoreductase; KEGG: tcx:Tcr_0823 NADH-quinone oxidoreductase, chain G YP_903497.1 PFAM: respiratory-chain NADH dehydrogenase, subunit 1; KEGG: tcx:Tcr_0824 respiratory-chain NADH dehydrogenase, subunit 1 YP_903498.1 Catalyzes the transfer of electrons from NADH to quinone YP_903499.1 PFAM: NADH-ubiquinone/plastoquinone oxidoreductase, chain 6; KEGG: noc:Noc_2556 NADH-ubiquinone/plastoquinone oxidoreductase, chain 6 YP_903500.1 PFAM: NADH-ubiquinone oxidoreductase, chain 4L; KEGG: rso:RSc2052 probable transmembrane NADH dehydrogenase I (chain K) oxidoreductase protein YP_903501.1 KEGG: eba:ebA4846 NADH dehydrogenase I, chain L; TIGRFAM: proton-translocating NADH-quinone oxidoreductase, chain L; PFAM: NADH-Ubiquinone oxidoreductase (complex I), chain 5/L domain protein; NADH/Ubiquinone/plastoquinone (complex I) YP_903502.1 KEGG: tcx:Tcr_0829 proton-translocating NADH-quinone oxidoreductase, chain M; TIGRFAM: proton-translocating NADH-quinone oxidoreductase, chain M; PFAM: NADH/Ubiquinone/plastoquinone (complex I) YP_903503.1 KEGG: tbd:Tbd_1155 NADH dehydrogenase I chain N; TIGRFAM: proton-translocating NADH-quinone oxidoreductase, chain N; PFAM: NADH/Ubiquinone/plastoquinone (complex I) YP_903504.1 PFAM: glycosyl hydrolase, BNR repeat-containing protein; KEGG: rso:RS05070 putative hemagglutinin/hemolysin-related protein YP_903506.1 PFAM: outer membrane efflux protein; KEGG: cvi:CV1734 probable outer membrane protein YP_903508.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: par:Psyc_1599 ABC drug efflux transporter, fused ATPase and inner mebrane subunits YP_903509.1 PFAM: secretion protein HlyD family protein; KEGG: par:Psyc_1598 HlyD family secretion protein YP_903510.1 TIGRFAM: biotin biosynthesis protein BioC; PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: tcx:Tcr_1981 biotin biosynthesis protein BioC YP_903511.1 PFAM: periplasmic solute binding protein; KEGG: rty:RT0013 probable zinc/manganese ABC transporter substrate binding protein YP_903512.1 PFAM: putative methyltransferase; methyltransferase, putative; Methyltransferase type 11; KEGG: vvy:VV2291 hypothetical protein YP_903514.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_903515.1 Catalyzes the phosphorylation of UMP to UDP YP_903516.1 TIGRFAM: excinuclease ABC, A subunit; PFAM: ABC transporter related; KEGG: vch:VC0394 excinuclease ABC, subunit A YP_903518.1 TIGRFAM: phosphoribosylglycinamide formyltransferase; PFAM: formyl transferase domain protein; KEGG: pha:PSHAa1948 phosphoribosylglycinamide formyltransferase 1 YP_903519.1 KEGG: eca:ECA1254 phosphoribosylaminoimidazole synthetase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein YP_903520.1 PFAM: CDP-alcohol phosphatidyltransferase; KEGG: noc:Noc_1186 CDP-alcohol phosphatidyltransferase YP_903521.1 PFAM: Chromosomal replication initiator, DnaA; KEGG: cbu:CBU_1734 chromosomal replication initiator protein DnaA YP_903523.1 TIGRFAM: uroporphyrin-III C-methyltransferase; siroheme synthase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: mfa:Mfla_0652 uroporphyrin-III C-methyltransferase YP_903524.1 KEGG: tcx:Tcr_1620 phosphoserine phosphatase SerB; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase YP_903525.1 TIGRFAM: cytochrome c-type biogenesis protein CcmF; PFAM: cytochrome c assembly protein; KEGG: psp:PSPPH_3309 cytochrome c-type biogenesis protein CcmF YP_903526.1 PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: dar:Daro_1405 TPR repeat YP_903527.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_903528.1 KEGG: vvy:VV2786 tRNA-(guanine-N1)-methyltransferase; TIGRFAM: tRNA (guanine-N1)-methyltransferase; PFAM: tRNA (guanine-N1-)-methyltransferase YP_903529.1 PFAM: nitrogen regulatory protein P-II; KEGG: mca:MCA2137 nitrogen regulatory protein P-II YP_903530.1 TIGRFAM: ammonium transporter; PFAM: Rh family protein/ammonium transporter; KEGG: cps:CPS_3995 ammonium transporter YP_903531.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_903532.1 KEGG: dar:Daro_0847 NlpBDapX lipoprotein YP_903533.1 PFAM: NAD-dependent DNA ligase; NAD-dependent DNA ligase, OB-fold; KEGG: dps:DP1006 related to NAD-dependent DNA ligase YP_903534.1 PFAM: nitrogen regulatory protein P-II; KEGG: sde:Sde_0232 nitrogen regulatory protein P-II (GlnB, GlnK) YP_903535.1 PFAM: CBS domain containing protein; KEGG: bxe:Bxe_A1873 hypothetical protein YP_903536.1 PFAM: ANTAR domain protein; KEGG: mca:MCA0588 response regulator NasT YP_903537.1 TIGRFAM: Sec-independent protein translocase, TatC subunit; PFAM: Sec-independent periplasmic protein translocase; KEGG: tcx:Tcr_1974 sec-independent protein translocase TatC YP_903538.1 TIGRFAM: twin-arginine translocation protein, TatB subunit; PFAM: sec-independent translocation protein mttA/Hcf106; KEGG: neu:NE0638 mttA/Hcf106 family YP_903539.1 TIGRFAM: twin-arginine translocation protein, TatA/E family subunit; PFAM: sec-independent translocation protein mttA/Hcf106; KEGG: ilo:IL2370 sec-independent protein secretion pathway component, TatA family YP_903540.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis YP_903541.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers YP_903542.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: tcx:Tcr_0140 glutathione reductase YP_903543.1 TIGRFAM: peptide chain release factor 2; PFAM: Class I peptide chain release factor; PCRF domain protein; KEGG: mca:MCA0302 peptide chain release factor 2, programmed frameshift YP_903544.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_903545.1 PFAM: lipid A biosynthesis acyltransferase; KEGG: psb:Psyr_1614 lipid A biosynthesis acyltransferase YP_903546.1 KEGG: pfo:Pfl_5148 DNA primase; TIGRFAM: DNA primase; PFAM: zinc finger, CHC2-family protein; TOPRIM domain protein; DNA primase catalytic core, N-terminal domain; SMART: Toprim sub domain protein YP_903547.1 PFAM: penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain; KEGG: tcx:Tcr_0562 peptidoglycan glycosyltransferase YP_903549.1 TIGRFAM: S-adenosyl-methyltransferase MraW; PFAM: methyltransferase; KEGG: tcx:Tcr_0559 methyltransferase YP_903551.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_903552.1 PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: tcx:Tcr_1389 6-pyruvoyl tetrahydropterin synthase and hypothetical protein YP_903553.1 similar protein in Methanocaldococcus converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate as the first step in methanopterin biosynthesis YP_903554.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_903555.1 TIGRFAM: DNA gyrase, A subunit; PFAM: DNA gyrase/topoisomerase IV, subunit A; DNA gyrase C-terminal repeat, beta-propeller; KEGG: mca:MCA1421 DNA gyrase, A subunit YP_903556.1 TIGRFAM: peptide chain release factor 3; small GTP-binding protein; PFAM: protein synthesis factor, GTP-binding; elongation factor Tu, domain 2 protein; KEGG: lpf:lpl0905 peptide chain release factor 3 YP_903557.1 PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: xcb:XC_0132 deoxycytidylate deaminase YP_903558.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_903559.1 PFAM: peptidylprolyl isomerase, FKBP-type; peptidyl-prolyl cis-trans isomerase, cyclophilin type; KEGG: tde:TDE2391 peptidyl-prolyl cis-trans isomerase YP_903560.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: par:Psyc_0327 putative 4Fe-4S ferredoxin YP_903561.1 PFAM: aminotransferase, class V; KEGG: cps:CPS_2190 aminotransferase, class V YP_903562.1 PFAM: FAD linked oxidase domain protein; KEGG: psp:PSPPH_3252 glycolate oxidase, GlcD subunit YP_903563.1 KEGG: eba:ebA4491 FAD linked oxidase YP_903564.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; protein of unknown function DUF224, cysteine-rich region domain protein; KEGG: neu:NE0673 glycolate oxidase (iron-sulfur subunit) protein YP_903565.1 SMART: Rhodanese domain protein; KEGG: pol:Bpro_0171 rhodanese-like YP_903566.1 PFAM: major facilitator superfamily MFS_1; KEGG: vvy:VV2596 putative AmpG protein YP_903567.1 PFAM: glycoside hydrolase, family 3 domain protein; KEGG: tbd:Tbd_0727 beta-N-acetylhexosaminidase YP_903569.1 PFAM: UvrD/REP helicase; KEGG: pha:PSHAa0122 DNA-dependent ATPase I YP_903571.1 TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein; KEGG: sde:Sde_1081 hypothetical protein YP_903572.1 PFAM: Redoxin domain protein; KEGG: tbd:Tbd_2118 thioredoxin YP_903573.1 TIGRFAM: arsenate reductase; PFAM: arsenate reductase and related; KEGG: sdn:Sden_1646 arsenate reductase YP_903574.1 PFAM: Glutathione S-transferase, N-terminal domain; KEGG: tcx:Tcr_1309 glutathione S-transferase-like YP_903575.1 TIGRFAM: iojap-like protein; PFAM: Iojap-related protein; KEGG: sde:Sde_3343 poly(A) polymerase, PcnB YP_903576.1 TIGRFAM: cytidyltransferase-related domain; nicotinate (nicotinamide) nucleotide adenylyltransferase; PFAM: cytidylyltransferase; KEGG: eca:ECA1306 nicotinate-nucleotide adenylyltransferase YP_903577.1 PFAM: beta-lactamase domain protein; KEGG: bsu:BG12648 involved in polyketide synthesis YP_903578.1 KEGG: eci:UTI89_C2927 ribosomal large subunit pseudouridine synthase D; TIGRFAM: pseudouridine synthase, RluA family; PFAM: RNA-binding S4 domain protein; pseudouridine synthase YP_903579.1 PFAM: peptidase S24, S26A and S26B; KEGG: tbd:Tbd_1516 hypothetical protein YP_903580.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_903581.1 KEGG: noc:Noc_1372 hypothetical protein YP_903583.1 PFAM: Citrate transporter; KEGG: sde:Sde_0065 Na+/H+ antiporter (NhaD family) YP_903584.1 TIGRFAM: putative transcriptional activator, Baf family; PFAM: Bordetella pertussis Bvg accessory factor; KEGG: cps:CPS_4744 putative transcriptional activator YP_903585.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_903586.1 TIGRFAM: Pseudouridine synthase, Rsu; PFAM: RNA-binding S4 domain protein; pseudouridine synthase; KEGG: noc:Noc_1041 pseudouridine synthase, Rsu YP_903587.1 TIGRFAM: isoleucyl-tRNA synthetase; KEGG: noc:Noc_2277 isoleucyl-tRNA synthetase, class Ia YP_903588.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_903590.1 TIGRFAM: glutamyl-tRNA(Gln) amidotransferase, C subunit; PFAM: Glu-tRNAGln amidotransferase, C subunit; KEGG: neu:NE2071 Glu-tRNAGln amidotransferase C subunit YP_903591.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_903592.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_903593.1 PFAM: protein of unknown function UPF0061; KEGG: vpa:VP0909 hypothetical protein YP_903594.1 PFAM: peptidase M50; KEGG: tcx:Tcr_1229 peptidase M50 YP_903595.1 TIGRFAM: prolyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S); Anticodon-binding domain protein; YbaK/prolyl-tRNA synthetase associated region; KEGG: hch:HCH_04773 prolyl-tRNA synthetase YP_903596.1 KEGG: mfa:Mfla_2122 phosphatidylserine decarboxylase; TIGRFAM: phosphatidylserine decarboxylase; PFAM: phosphatidylserine decarboxylase-related YP_903597.1 PFAM: CBS domain containing protein; protein of unknown function DUF21; transporter-associated region; KEGG: noc:Noc_2263 hypothetical protein YP_903598.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_903599.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_903600.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_903601.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_903602.1 TIGRFAM: putative methyltransferase; PFAM: conserved hypothetical protein 95; KEGG: ilo:IL0225 N6-adenine-specific methylase YP_903603.1 PFAM: Inorganic pyrophosphatase; KEGG: ilo:IL2263 inorganic pyrophosphatase YP_903604.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: noc:Noc_3018 signal transduction histidine kinase, NtrY YP_903605.1 PFAM: response regulator receiver; helix-turn-helix, Fis-type; KEGG: pol:Bpro_4433 two component transcriptional regulator, fis family YP_903606.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_903607.1 TIGRFAM: potassium uptake protein, TrkH family; PFAM: cation transporter; KEGG: hch:HCH_00025 trk-type K+ transport system, membrane components YP_903608.1 helicase involved in DNA repair and perhaps also replication YP_903609.1 PFAM: Polyprenyl synthetase; KEGG: ftl:FTL_1041 octaprenyl-diphosphate synthase YP_903610.1 PFAM: ribosomal RNA methyltransferase RrmJ/FtsJ; KEGG: sde:Sde_2721 ribosomal RNA methyltransferase RrmJ/FtsJ YP_903611.1 TIGRFAM: small GTP-binding protein; GTP-binding protein TypA; PFAM: elongation factor G domain protein; protein synthesis factor, GTP-binding; elongation factor Tu, domain 2 protein; KEGG: sec:SC3900 GTP-binding elongation factor family protein YP_903612.1 PFAM: acriflavin resistance protein; KEGG: lil:LA2439 acriflavine resistance protein homolog YP_903613.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_903614.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_903615.1 TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase, class-II; asparagine synthase; KEGG: tbd:Tbd_0060 asparagine synthase, glutamine-hydrolyzing YP_903616.1 PFAM: ribonuclease H; KEGG: ftl:FTL_0854 ribonuclease H YP_903617.1 KEGG: tbd:Tbd_2669 hypothetical protein YP_903618.1 PFAM: cyclase/dehydrase; KEGG: vpa:VP0645 hypothetical protein YP_903619.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_903620.1 PFAM: histone family protein DNA-binding protein; KEGG: mca:MCA0532 DNA-binding protein HU-beta YP_903621.1 PFAM: nucleoside diphosphate kinase; KEGG: mfa:Mfla_1624 nucleoside-diphosphate kinase YP_903622.1 TIGRFAM: radical SAM enzyme, Cfr family; PFAM: Radical SAM domain protein; KEGG: lpp:lpp1504 hypothetical protein YP_903624.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_903625.1 KEGG: cps:CPS_2123 hypothetical protein YP_903626.1 TIGRFAM: deoxyxylulose-5-phosphate synthase; PFAM: Transketolase, central region; Transketolase domain protein; KEGG: mca:MCA0817 1-deoxy-D-xylulose-5-phosphate synthase YP_903627.1 PFAM: peptidase U32; KEGG: son:SO1252 peptidase, U32 family YP_903628.1 PFAM: methyltransferase small; KEGG: tcx:Tcr_0213 methyltransferase small YP_903629.1 TIGRFAM: glutaredoxin-like protein; PFAM: glutaredoxin; KEGG: tbd:Tbd_2499 glutaredoxin-related protein YP_903630.1 PFAM: protein of unknown function DUF45; KEGG: chy:CHY_0833 hypothetical protein YP_903631.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_903632.1 PFAM: protein of unknown function DUF28; KEGG: ilo:IL1088 uncharacterized conserved enzyme YP_903633.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_903634.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_903635.1 PFAM: protein of unknown function DUF502; KEGG: mfa:Mfla_2385 protein of unknown function DUF502 YP_903636.1 TIGRFAM: methionine aminopeptidase, type I; PFAM: peptidase M24; KEGG: lpp:lpp1684 methionyl aminopeptidase YP_903637.1 PFAM: peptidase M48, Ste24p; KEGG: vvy:VVA0973 Zn-dependent protease with chaperone function YP_903638.1 PFAM: LemA family protein; KEGG: sde:Sde_3150 divalent cation transporter YP_903639.1 KEGG: lpp:lpp1339 DNA polymerase III epsilon subunit; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease, RNase T and DNA polymerase III; SMART: Exonuclease YP_903640.1 TIGRFAM: DNA-directed RNA polymerase, omega subunit; PFAM: RNA polymerase Rpb6; KEGG: psp:PSPPH_0198 DNA-directed RNA polymerase omega chain (RNAP omegasubunit) (transcriptase omega chain) (RNA polymerase omega subunit) YP_903642.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_903643.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_903644.1 PFAM: Three-deoxy-D-manno-octulosonic-acid transferase domain protein; KEGG: plu:plu4854 3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase) YP_903645.1 TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; GTP1/OBG sub domain protein; KEGG: lpp:lpp2702 hypothetical protein YP_903646.1 KEGG: tcx:Tcr_0344 glutamate 5-kinase; TIGRFAM: glutamate 5-kinase; PFAM: aspartate/glutamate/uridylate kinase YP_903647.1 KEGG: hit:NTHI0077 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK YP_903648.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_903649.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_903650.1 PFAM: HesB/YadR/YfhF-family protein; nitrogen-fixing NifU domain protein; KEGG: hch:HCH_02543 thioredoxin-like protein YP_903651.1 KEGG: tcx:Tcr_0164 hypothetical protein YP_903652.1 TIGRFAM: thiamine-monophosphate kinase; PFAM: AIR synthase related protein domain protein; KEGG: hit:NTHI1618 thiamine-monophosphate kinase YP_903653.1 TIGRFAM: RNA polymerase-binding protein DksA; PFAM: zinc finger, DksA/TraR C4-type; KEGG: aci:ACIAD0273 DnaK suppressor protein YP_903654.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: tcx:Tcr_1242 HAD-superfamily hydrolase subfamily IA, variant 3 YP_903655.1 TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: cbu:CBU_1200 isocitrate dehydrogenase, NADP-dependent YP_903656.1 KEGG: pfa:PF14_0644 hypothetical protein YP_903657.1 PFAM: aminotransferase, class I and II; KEGG: hch:HCH_04972 aspartate/tyrosine/aromatic aminotransferase YP_903658.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_903659.1 PFAM: Radical SAM domain protein; KEGG: mfa:Mfla_2336 radical SAM YP_903660.1 PFAM: heat shock protein Hsp20; KEGG: rfe:RF_1004 small heat shock protein YP_903661.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_903662.1 KEGG: mca:MCA1094 orotidine 5'-phosphate decarboxylase; TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase YP_903663.1 TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: monooxygenase, FAD-binding; KEGG: ngo:NGO1678 hypothetical protein YP_903664.1 KEGG: tcx:Tcr_1992 pyridoxamine 5'-phosphate oxidase; TIGRFAM: pyridoxamine 5'-phosphate oxidase; PFAM: pyridoxamine 5'-phosphate oxidase-related, FMN-binding YP_903665.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_903666.1 TIGRFAM: ribonuclease, Rne/Rng family; PFAM: RNA binding S1 domain protein; KEGG: tcx:Tcr_0703 ribonuclease, Rne/Rng family YP_903667.1 PFAM: short-chain dehydrogenase/reductase SDR; KEGG: nmu:Nmul_A0336 short-chain dehydrogenase/reductase SDR YP_903668.1 PFAM: protein of unknown function DUF185; KEGG: noc:Noc_0037 protein of unknown function DUF185 YP_903669.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_903670.1 TIGRFAM: aminopeptidase N; PFAM: peptidase M1, membrane alanine aminopeptidase; KEGG: noc:Noc_1314 peptidase M, neutral zinc metallopeptidase, zinc-binding site YP_903671.1 PFAM: CinA domain protein; KEGG: reu:Reut_A2850 CinA, C-terminal YP_903672.1 TIGRFAM: TIM-barrel protein, yjbN family; PFAM: dihydrouridine synthase, DuS; KEGG: noc:Noc_2960 dihydrouridine synthase TIM-barrel protein YjbN YP_903673.1 PFAM: cell division protein FtsA; KEGG: mca:MCA2424 cell division protein FtsA YP_903674.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_903675.1 TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: mca:MCA2270 acetolactate synthase, large subunit, biosynthetic type YP_903676.1 TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: dar:Daro_3074 acetolactate synthase, small subunit YP_903677.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_903678.1 KEGG: tcx:Tcr_0610 CDP-diacylglycerol--serine O-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase YP_903679.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_903681.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_903682.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine YP_903683.1 TIGRFAM: ribosomal subunit interface protein; PFAM: sigma 54 modulation protein/ribosomal protein S30EA; KEGG: ilo:IL0395 S30EA ribosomal protein YP_903684.1 TIGRFAM: magnesium transporter; PFAM: CBS domain containing protein; MgtE integral membrane region; MgtE intracellular region; KEGG: hch:HCH_05326 magnesium transporter YP_903685.1 PFAM: phosphoglucomutase/phosphomannomutase C terminal; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; KEGG: noc:Noc_2994 phosphomannomutase YP_903686.1 PFAM: Positive regulator of sigma(E), RseC/MucC; KEGG: eca:ECA3281 sigma-E factor regulatory protein YP_903687.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_903689.1 KEGG: hch:HCH_01244 polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase); PFAM: 3' exoribonuclease; RNA binding S1 domain protein; KH, type 1, domain protein; SMART: KH domain protein YP_903690.1 KEGG: mca:MCA0291 inosine-5'-monophosphate dehydrogenase; TIGRFAM: inosine-5'-monophosphate dehydrogenase; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase; 2-nitropropane dioxygenase, NPD YP_903691.1 PFAM: SH3, type 3 domain protein; KEGG: tcx:Tcr_1504 SH3-like region YP_903692.1 TIGRFAM: valyl-tRNA synthetase; KEGG: tcx:Tcr_1503 valyl-tRNA synthetase YP_903693.1 KEGG: neu:NE0433 DNA polymerase III (subunits tau and gamma) protein; TIGRFAM: DNA polymerase III, subunits gamma and tau; PFAM: AAA ATPase, central domain protein; SMART: AAA ATPase YP_903694.1 PFAM: Nucleotidyl transferase; KEGG: pha:PSHAa2630 mannose-1-phosphate guanyltransferase-related protein YP_903695.1 PFAM: aminoglycoside phosphotransferase; KEGG: neu:NE0191 domain of unknown function DUF227 YP_903696.1 PFAM: aminotransferase, class IV; KEGG: noc:Noc_2631 D-alanine transaminase YP_903697.1 PFAM: peptidase S11, D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: lpf:lpl1517 D-alanyl-D-alanine carboxypeptidase YP_903698.1 TIGRFAM: rod shape-determining protein RodA; PFAM: cell cycle protein; KEGG: ppr:PBPRA2891 putative rod shape-determining protein RodA YP_903699.1 PFAM: protein of unknown function DUF498; KEGG: cvi:CV0994 hypothetical protein YP_903700.1 PFAM: Sel1 domain protein repeat-containing protein; KEGG: hit:NTHI1567 hypothetical protein YP_903701.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_903702.1 KEGG: pae:PA3658 protein-PII uridylyltransferase; TIGRFAM: protein-P-II uridylyltransferase; PFAM: amino acid-binding ACT domain protein; DNA polymerase, beta domain protein region; metal-dependent phosphohydrolase, HD sub domain; GlnD PII-uridylyltransferase; SMART: metal-dependent phosphohydrolase, HD region YP_903703.1 TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: ppr:PBPRA3541 putative thioredoxin YP_903704.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_903705.1 PFAM: permease YjgP/YjgQ family protein; KEGG: mfa:Mfla_0221 permease YjgP/YjgQ YP_903706.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis YP_903707.1 TIGRFAM: poly(A) polymerase; PFAM: Polynucleotide adenylyltransferase region; KEGG: tcx:Tcr_1528 poly(A) polymerase YP_903708.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_903709.1 PFAM: Polyprenyl synthetase; KEGG: pfo:Pfl_5006 polyprenyl synthetase YP_903710.1 KEGG: nme:NMB1916 3-oxoacyl-(acyl-carrier-protein) synthase III; TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) synthase III; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III YP_903711.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_903712.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_903713.1 PFAM: protein of unknown function DUF177; KEGG: yps:YPTB2476 hypothetical protein YP_903714.1 PFAM: phospholipid/glycerol acyltransferase; KEGG: mfa:Mfla_0642 phospholipid/glycerol acyltransferase YP_903715.1 KEGG: sde:Sde_2151 flagellar FliJ and related; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase YP_903716.1 PFAM: protein of unknown function DUF195; KEGG: wsu:WS1465 hypothetical protein YP_903717.1 PFAM: short-chain dehydrogenase/reductase SDR; KEGG: vfi:VF1039 short chain dehydrogenase YP_903718.1 PFAM: inositol monophosphatase; KEGG: eba:ebA6410 inositol monophosphatase (extragenic suppressor protein) YP_903719.1 TIGRFAM: RNA methyltransferase, TrmH family, group 1; PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: tcx:Tcr_0615 RNA methyltransferase TrmH, group 1 YP_903720.1 molecular chaperone YP_903721.1 PFAM: SUA5/yciO/yrdC, N-terminal domain; KEGG: cps:CPS_0027 putative RNA-binding protein YP_903722.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_903723.1 PFAM: SirA family protein; KEGG: noc:Noc_2653 SirA-like protein YP_903724.1 KEGG: mca:MCA1677 glutamine synthetase, type I; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp YP_903725.1 KEGG: ilo:IL1324 biotin synthase; TIGRFAM: biotin synthase; PFAM: Radical SAM domain protein; biotin and thiamin synthesis associated; SMART: Elongator protein 3/MiaB/NifB YP_903726.1 KEGG: pst:PSPTO4408 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; TIGRFAM: UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; PFAM: glycosyl transferase, family 28; Glycosyltransferase 28, C-terminal domain YP_903727.1 PFAM: cell cycle protein; KEGG: lpp:lpp2668 cell division protein FtsW YP_903728.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: tcx:Tcr_1606 ABC transporter related YP_903729.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_903730.1 PFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase; GTP cyclohydrolase II; KEGG: tcx:Tcr_1398 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_903731.1 PFAM: 6,7-dimethyl-8-ribityllumazine synthase; KEGG: fnu:FN1505 6,7-dimethyl-8-ribityllumazine synthase YP_903732.1 TIGRFAM: transcription antitermination factor NusB; PFAM: NusB/RsmB/TIM44; KEGG: yps:YPTB0936 transcription termination; L factor YP_903734.1 PFAM: histidine triad (HIT) protein; KEGG: rfr:Rfer_1209 histidine triad (HIT) protein YP_903735.1 TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n; KEGG: stt:t4237 single strand binding protein YP_903736.1 PFAM: major facilitator superfamily MFS_1; KEGG: tcx:Tcr_0326 major facilitator superfamily MFS_1 YP_903737.1 KEGG: noc:Noc_0716 probable transmembrane protein YP_903738.1 KEGG: tcx:Tcr_2144 (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA; TIGRFAM: RelA/SpoT family protein; PFAM: amino acid-binding ACT domain protein; TGS domain protein; metal-dependent phosphohydrolase, HD sub domain; RelA/SpoT domain protein; SMART: metal-dependent phosphohydrolase, HD region YP_903739.1 PFAM: protein of unknown function DUF528; KEGG: bur:Bcep18194_A5426 protein of unknown function DUF528 YP_903740.1 PFAM: TolB, N-terminal domain protein; WD40 domain protein beta Propeller; KEGG: noc:Noc_0145 TolB YP_903741.1 PFAM: OmpA/MotB domain protein; KEGG: noc:Noc_0146 OmpA/MotB YP_903742.1 PFAM: Tetratricopeptide TPR_2 repeat protein; KEGG: psp:PSPPH_3765 hypothetical protein YP_903743.1 PFAM: Anthranilate synthase component I and chorismate binding protein; Anthranilate synthase component I domain protein; KEGG: tcx:Tcr_0715 anthranilate synthase YP_903744.1 PFAM: multiple antibiotic resistance (MarC)-related proteins; KEGG: cps:CPS_1844 conserved hypothetical protein TIGR00427 YP_903745.1 KEGG: tcx:Tcr_1372 NAD+ synthetase; TIGRFAM: NAD+ synthetase; PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; NAD+ synthase; ExsB family protein YP_903746.1 KEGG: mhu:Mhun_1900 putative transcriptional regulator YP_903747.1 PFAM: ferrochelatase; KEGG: tcx:Tcr_1864 ferrochelatase YP_903748.1 Catalyzes the rate-limiting step in dNTP synthesis YP_903749.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA YP_903750.1 PFAM: ferredoxin; KEGG: sgl:SG1586 hypothetical protein YP_903751.1 KEGG: tdn:Tmden_0484 putative dUTPase YP_903752.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_903753.1 PFAM: GCN5-related N-acetyltransferase; KEGG: reu:Reut_A2066 amino-acid N-acetyltransferase (ArgA) YP_903754.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_903755.1 KEGG: mfa:Mfla_1626 ribonuclease R; TIGRFAM: VacB and RNase II family 3'-5' exoribonucleases; ribonuclease R; PFAM: ribonuclease II; RNA binding S1 domain protein; Ribonuclease B, OB region N-terminal domain; SMART: Cold shock protein YP_903756.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_903757.1 KEGG: tbd:Tbd_0606 ATP phosphoribosyltransferase regulatory subunit YP_903758.1 TIGRFAM: HflC protein; PFAM: band 7 protein; KEGG: tcx:Tcr_1091 HflC protein YP_903759.1 TIGRFAM: HflK protein; PFAM: band 7 protein; KEGG: tcx:Tcr_1090 HflK protein YP_903760.1 PFAM: OstA family protein; Organic solvent tolerance protein; KEGG: rso:RSc0515 probable organic solvent tolerance transmembrane protein YP_903761.1 PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase; KEGG: lpn:lpg0298 peptidyl-prolyl cis-trans isomerase D (SurA) YP_903762.1 TIGRFAM: RNA methyltransferase, TrmH family, group 3; PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase, substrate binding; KEGG: eca:ECA3621 probable tRNA/rRNA methyltransferase YP_903763.1 TIGRFAM: isocitrate lyase; PFAM: isocitrate lyase and phosphorylmutase; KEGG: son:SO1484 isocitrate lyase YP_903764.1 PFAM: protein of unknown function DUF493; KEGG: neu:NE1487 hypothetical protein YP_903765.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_903766.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_903767.1 PFAM: acriflavin resistance protein; KEGG: gme:Gmet_3127 acriflavin resistance protein YP_903768.1 TIGRFAM: efflux transporter, RND family, MFP subunit; KEGG: pha:PSHAa2832 multidrug efflux system (AcrA/AcrE) YP_903769.1 KEGG: sde:Sde_0738 4-hydroxythreonine-4-phosphate dehydrogenase; TIGRFAM: 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate biosynthetic protein PdxA YP_903770.1 TIGRFAM: dimethyladenosine transferase; PFAM: ribosomal RNA adenine methylase transferase; KEGG: pfo:Pfl_5135 16S rRNA dimethylase YP_903771.1 protein associated with Co2+ and Mg2+ efflux YP_903772.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_903773.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_903774.1 PFAM: protein of unknown function DUF971; KEGG: eba:ebB94 hypothetical protein YP_903775.1 TIGRFAM: putative membrane-associated zinc metalloprotease; PFAM: PDZ/DHR/GLGF domain protein; peptidase M50; KEGG: neu:NE1711 membrane-associated Zn-dependent proteases 1 YP_903776.1 PFAM: surface antigen (D15); surface antigen variable number repeat protein; KEGG: eba:ebA5996 probable outer membrane protein/surface antigen YP_903777.1 TIGRFAM: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; PFAM: transferase hexapeptide repeat containing protein; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; KEGG: ftl:FTL_0537 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_903778.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_903779.1 TIGRFAM: acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase; KEGG: pae:PA3644 UDP-N-acetylglucosamine acyltransferase YP_903780.1 TIGRFAM: integral membrane protein MviN; PFAM: multi antimicrobial extrusion protein MatE; virulence factor MVIN family protein; KEGG: tcx:Tcr_0493 integral membrane protein MviN YP_903781.1 PFAM: Fe(II) trafficking protein YggX; KEGG: dar:Daro_3583 hypothetical protein YP_903782.1 Essential for recycling GMP and indirectly, cGMP YP_903783.1 TIGRFAM: RNA polymerase sigma factor RpoH; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; KEGG: ilo:IL0229 DNA-directed RNA polymerase sigma 32 subunit YP_903784.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_903785.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_903786.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_903787.1 TIGRFAM: exsB protein; PFAM: ExsB family protein; KEGG: cbu:CBU_2083 ExsB protein YP_903788.1 carries the fatty acid chain in fatty acid biosynthesis YP_903789.1 PFAM: beta-ketoacyl synthase; KEGG: bxe:Bxe_A1076 3-oxoacyl-(acyl-carrier-protein) synthase II YP_903791.1 PFAM: peptidase M3A and M3B, thimet/oligopeptidase F; KEGG: pha:PSHAa0361 oligopeptidase A YP_903792.1 TIGRFAM: methionyl-tRNA synthetase; KEGG: vfi:VF1754 methionyl-tRNA synthetase YP_903793.1 PFAM: protein of unknown function DUF59; KEGG: tbd:Tbd_2108 ATP-binding protein involved in chromosome partitioning YP_903794.1 TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: reu:Reut_A1064 ferredoxin, 2Fe-2S type YP_903795.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_903796.1 TIGRFAM: co-chaperone Hsc20; PFAM: heat shock protein DnaJ domain protein; HSCB oligomerisation domain protein; KEGG: sdy:SDY_2723 hypothetical protein YP_903797.1 TIGRFAM: iron-sulfur cluster assembly accessory protein; iron-sulfur cluster assembly protein IscA; PFAM: HesB/YadR/YfhF-family protein; KEGG: vvy:VV0757 hypothetical protein YP_903798.1 TIGRFAM: FeS cluster assembly scaffold IscU; PFAM: nitrogen-fixing NifU domain protein; KEGG: par:Psyc_1478 nitrogen-fixing NifU-like YP_903799.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_903800.1 TIGRFAM: putative transcriptional regulator, Rrf2 family; PFAM: protein of unknown function UPF0074; KEGG: tcx:Tcr_0617 transcriptional regulator, BadM/Rrf2 family YP_903801.1 TIGRFAM: serine O-acetyltransferase; KEGG: tcx:Tcr_0616 serine O-acetyltransferase YP_903802.1 PFAM: lipid A biosynthesis acyltransferase; KEGG: tcx:Tcr_0183 lipid A biosynthesis acyltransferase YP_903803.1 PFAM: PP-loop domain protein; KEGG: tcx:Tcr_0182 PP-loop YP_903804.1 KEGG: bfr:BF4142 outer membrane efflux protein YP_903805.1 PFAM: shikimate kinase; KEGG: csa:Csal_0613 shikimate kinase YP_903806.1 TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase, class IV; KEGG: hch:HCH_01045 branched-chain amino acid aminotransferase YP_903807.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_903809.1 PFAM: peptidase M48, Ste24p; KEGG: neu:NE0076 peptidase family M48 YP_903810.1 KEGG: dar:Daro_3003 hypothetical protein YP_903811.1 TIGRFAM: ribosome small subunit-dependent GTPase A; PFAM: GTPase EngC; KEGG: hch:HCH_05392 predicted GTPase YP_903812.1 PFAM: protein of unknown function DUF423; KEGG: oih:OB3027 hypothetical protein YP_903813.1 PFAM: histone family protein DNA-binding protein; KEGG: aba:Acid345_4105 histone-like DNA-binding protein YP_903814.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_903815.1 KEGG: hch:HCH_04979 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region YP_903816.1 TIGRFAM: lysyl-tRNA synthetase; PFAM: tRNA synthetase, class II (D, K and N); nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: tcx:Tcr_0726 lysyl-tRNA synthetase YP_903817.1 PFAM: cytochrome C biogenesis protein; KEGG: rme:Rmet_2392 cytochrome c biogenesis protein YP_903818.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: vvu:VV12632 ATPase component of ABC transporter with duplicated ATPase domains YP_903819.1 KEGG: bms:BRA0855 hypothetical protein YP_903820.1 TIGRFAM: excinuclease ABC, C subunit; PFAM: Excinuclease ABC, C subunit domain protein; excinuclease ABC, C subunit domain protein; UvrB/UvrC protein; KEGG: plu:plu2027 excinuclease ABC subunit C YP_903821.1 PFAM: toluene tolerance family protein; KEGG: neu:NE2381 putative signal peptide protein YP_903822.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_903823.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ YP_903824.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_903825.1 KEGG: tcx:Tcr_0998 signal recognition particle protein; TIGRFAM: signal recognition particle protein; PFAM: GTP-binding signal recognition particle SRP54, G- domain; Signal peptide binding (SRP54) M- domain protein; SMART: AAA ATPase YP_903826.1 PFAM: cytochrome c assembly protein; KEGG: mca:MCA1337 hypothetical protein YP_903827.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_903828.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein; KEGG: csa:Csal_2817 alkyl hydroperoxide reductase/thiol specific antioxidant/Mal allergen YP_903829.1 KEGG: psp:PSPPH_3670 ubiquinone biosynthesis O-methyltransferase; TIGRFAM: ubiquinone biosynthesis O-methyltransferase; PFAM: NodS family protein; Methyltransferase type 11; Methyltransferase type 12 YP_903831.1 KEGG: mfa:Mfla_1012 phosphopantethiene--protein transferase domain; TIGRFAM: holo-acyl-carrier-protein synthase; Phosphopantethiene-protein transferase; PFAM: 4'-phosphopantetheinyl transferase YP_903832.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_903833.1 TIGRFAM: small GTP-binding protein; GTP-binding; GTP-binding protein Era; PFAM: GTP-binding protein, HSR1-related; KH, type 2 domain protein; Miro domain protein; KEGG: tcx:Tcr_0735 GTP-binding protein Era YP_903834.1 PFAM: ribonuclease III; double-stranded RNA binding domain protein; KEGG: vfi:VF2087 ribonuclease III YP_903835.1 KEGG: tbd:Tbd_2487 hypothetical protein YP_903836.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_903837.1 PFAM: prolipoprotein diacylglyceryl transferase; KEGG: noc:Noc_0233 prolipoprotein diacylglyceryl transferase YP_903838.1 PFAM: regulatory protein, ArsR; KEGG: tcx:Tcr_1782 transcriptional regulator, ArsR family YP_903840.1 KEGG: hch:HCH_01350 periplasmic protease; TIGRFAM: carboxyl-terminal protease; PFAM: PDZ/DHR/GLGF domain protein; peptidase S41 YP_903841.1 KEGG: mca:MCA1465 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: peptidase S24, S26A and S26B YP_903842.1 PFAM: DsrC family protein; KEGG: buc:BU467 putative sulfite reductase YP_903843.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_903844.1 PFAM: Prephenate dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: tcx:Tcr_1195 prephenate dehydrogenase YP_903845.1 TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: ilo:IL1358 histidinol-phosphate/aromatic aminotransferase YP_903846.1 TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase; amino acid-binding ACT domain protein; KEGG: csa:Csal_2166 chorismate mutase YP_903847.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: noc:Noc_0173 D-isomer specific 2-hydroxyacid dehydrogenase YP_903848.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_903849.1 TIGRFAM: Ribonucleotide reductase regulator NrdR-like; PFAM: ATP-cone domain protein; KEGG: cbu:CBU_1418 conserved hypothetical protein TIGR00244 YP_903850.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_903851.1 PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: pfo:Pfl_4746 UBA/ThiF-type NAD/FAD binding fold YP_903852.1 KEGG: pha:PSHAa2274 protein-methionine-S-oxide reductase (peptide Met(O) reductase); TIGRFAM: peptide methionine sulfoxide reductase; PFAM: Methionine sulfoxide reductase A YP_903853.1 KEGG: lpp:plpp0108 hypothetical protein YP_903855.1 PFAM: protein of unknown function UPF0118; KEGG: tcx:Tcr_1881 hypothetical protein YP_903857.1 PFAM: histone family protein DNA-binding protein; KEGG: msu:MS1089 bacterial nucleoid DNA-binding protein YP_903858.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_903859.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_903860.1 KEGG: tbd:Tbd_0170 outer membrane lipoprotein, putative YP_903861.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_903862.1 PFAM: ribosomal protein L35; KEGG: ilo:IL1397 ribosomal protein L35 YP_903863.1 TIGRFAM: translation initiation factor IF-3; PFAM: initiation factor 3; KEGG: ppu:PP2466 translation initiation factor IF-3 YP_903864.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_903865.1 TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; PFAM: phosphoesterase, RecJ domain protein; phosphoesterase, DHHA1; KEGG: lpn:lpg1461 single stranded DNA specific exonuclease RecJ YP_903866.1 KEGG: hch:HCH_00116 hypothetical protein YP_903867.1 PFAM: FAD dependent oxidoreductase; KEGG: csa:Csal_0494 glycine oxidase ThiO YP_903868.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_903869.1 PFAM: short-chain dehydrogenase/reductase SDR; KEGG: noc:Noc_1769 short-chain dehydrogenase/reductase SDR YP_903871.1 PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase; KEGG: tcx:Tcr_1096 PpiC-type peptidyl-prolyl cis-trans isomerase YP_903872.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_903874.1 TIGRFAM: heme exporter protein CcmC; PFAM: cytochrome c assembly protein; KEGG: noc:Noc_0946 cytochrome c-type biogenesis protein CcmC YP_903875.1 PFAM: peptidase M22, glycoprotease; KEGG: noc:Noc_0917 peptidase M22, glycoprotease YP_903876.1 PFAM: glycosyl transferase, family 51; KEGG: cps:CPS_4301 penicillin-binding protein YP_903877.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_903878.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_903879.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_903880.1 TIGRFAM: replicative DNA helicase; PFAM: DnaB domain protein helicase, N-terminal domain protein; DnaB domain protein helicase, C-terminal domain protein; KEGG: noc:Noc_0223 DnaB helicase YP_903881.1 KEGG: cbu:CBU_0869 alanine racemase; TIGRFAM: alanine racemase; PFAM: alanine racemase domain protein YP_903882.1 PFAM: metallophosphoesterase; KEGG: cyb:CYB_0131 icc protein YP_903883.1 PFAM: 5-nucleotidase; KEGG: noc:Noc_1810 5-nucleotidase YP_903884.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_903885.1 KEGG: pha:PSHAb0136 puttive membrane-associated protein with TPR-like domain YP_903886.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_903887.2 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_903888.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase; KEGG: tbd:Tbd_2507 lipid A export ATP-binding/permease protein MsbA YP_903889.1 PFAM: glycosyl transferase, family 3; KEGG: tbd:Tbd_0270 anthranilate phosphoribosyltransferase-like protein YP_903890.1 PFAM: Rieske [2Fe-2S] domain protein; KEGG: tbd:Tbd_0271 putative dioxygenase ferredoxin subunit YP_903891.1 PFAM: Lytic transglycosylase, catalytic; KEGG: cps:CPS_4077 putative lipoprotein YP_903892.1 PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein YP_903893.1 KEGG: tcx:Tcr_1759 thioredoxin, putative YP_903894.1 TIGRFAM: uracil-DNA glycosylase; PFAM: Uracil-DNA glycosylase superfamily; KEGG: bba:Bd3500 uracil-DNA glycosylase YP_903895.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: tcx:Tcr_0451 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_903896.1 PFAM: molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; KEGG: mca:MCA0590 nitrate reductase YP_903897.1 PFAM: protein kinase; protein phosphatase 2C domain protein; SMART: tyrosine protein kinase; serine/threonine protein kinase; KEGG: hch:HCH_05817 serine/threonine protein kinase YP_903898.1 PFAM: major facilitator superfamily MFS_1; KEGG: sde:Sde_2277 conserved hypothetical nitrate transporter YP_903899.1 TIGRFAM: nitrite reductase [NAD(P)H], large subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region; BFD domain protein [2Fe-2S]-binding domain protein; KEGG: mca:MCA0592 nitrite reductase [NAD(P)H], large subunit YP_903900.1 PFAM: molybdopterin biosynthesis MoaE; KEGG: vvu:VV13084 molybdenum cofactor biosynthesis protein E YP_903901.1 TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein A; KEGG: son:SO4722 molybdopterin-guanine dinucleotide biosynthesis protein YP_903902.1 TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain; MoeA domain protein, domain I and II; MoeA domain protein, domain IV; KEGG: tcx:Tcr_0161 molybdopterin binding domain MoeA YP_903903.1 TIGRFAM: molybdenum cofactor biosynthesis protein C; PFAM: molybdopterin cofactor biosynthesis MoaC region; KEGG: tcx:Tcr_0162 molybdenum cofactor biosynthesis protein C YP_903904.1 KEGG: tcx:Tcr_0158 molybdenum cofactor synthesis-like; TIGRFAM: molybdenum cofactor biosynthesis protein A; PFAM: Radical SAM domain protein; molybdenum cofactor synthesis domain protein; SMART: Elongator protein 3/MiaB/NifB YP_903905.1 PFAM: thiamineS protein; KEGG: dar:Daro_1784 molybdopterin converting factor, subunit 1 YP_903906.1 TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain; KEGG: tcx:Tcr_1547 molybdopterin binding domain YP_903907.1 PFAM: von Willebrand factor, type A; KEGG: tcx:Tcr_0422 von Willebrand factor, type A YP_903908.1 PFAM: ATPase associated with various cellular activities, AAA_5; CbbQ/NirQ/NorQ C-terminal domain protein; SMART: AAA ATPase; KEGG: tcx:Tcr_0423 ATPase associated with various cellular activities, AAA_5 YP_903909.1 catalyzes the carboxylation of D-ribulose 1,5-bisphosphate in carbon dioxide fixation YP_903910.1 KEGG: tcx:Tcr_0590 arginine biosynthesis bifunctional protein ArgJ; TIGRFAM: arginine biosynthesis bifunctional protein ArgJ; PFAM: arginine biosynthesis protein ArgJ YP_903911.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: pst:PSPTO0315 iron ABC transporter, permease protein YP_903912.1 PFAM: extracellular solute-binding protein, family 1; KEGG: tbd:Tbd_0990 ABC transporter, iron binding protein YP_903913.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: eba:ebA4892 probable transport system ATP-binding protein YP_903914.1 PFAM: multicopper oxidase, type 2; multicopper oxidase, type 3; KEGG: tcx:Tcr_1576 bilirubin oxidase YP_903916.1 PFAM: protein of unknown function DUF1111; KEGG: pae:PA4371 hypothetical protein YP_903917.1 KEGG: vpa:VP1920 putative iron-regulated protein A YP_903918.1 TIGRFAM: cation diffusion facilitator family transporter; PFAM: cation efflux protein; KEGG: lpf:lpl2012 hypothetical protein YP_903919.1 TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: tcx:Tcr_1385 thioredoxin YP_903920.1 TIGRFAM: conserved hypothetical protein; PFAM: arsenate reductase and related; KEGG: pha:PSHAa1332 enzyme with thioredoxin-like domain YP_903921.1 KEGG: tcx:Tcr_0163 hypothetical protein YP_903923.1 KEGG: cbu:CBU_1914 glycyl-tRNA synthetase, beta subunit YP_903924.1 KEGG: noc:Noc_2908 hypothetical protein YP_903925.1 KEGG: tcx:Tcr_0897 TolA YP_903926.1 PFAM: Biopolymer transport protein ExbD/TolR; KEGG: ftl:FTL_0332 TolR protein YP_903927.1 PFAM: MotA/TolQ/ExbB proton channel; KEGG: ilo:IL1083 TonB system biopolymer transport component YP_903929.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_903930.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_903931.1 PFAM: ABC-3 protein; KEGG: ppr:PBPRA1053 putative ABC-type Mn2+/Zn2+ transport system, permease component YP_903932.1 PFAM: ferric-uptake regulator; KEGG: noc:Noc_1194 ferric-uptake regulator YP_903933.1 PFAM: SmpA/OmlA domain protein; KEGG: nmu:Nmul_A0476 SmpA/OmlA YP_903934.1 PFAM: peptidase S49; KEGG: tcx:Tcr_1144 peptidase S49 YP_903935.1 TIGRFAM: heme exporter protein CcmA; PFAM: ABC transporter related; KEGG: vfi:VF1824 heme exporter protein A YP_903936.1 TIGRFAM: heme exporter protein CcmB; PFAM: cytochrome c-type biogenesis protein CcmB; KEGG: cps:CPS_1033 heme exporter protein CcmB YP_903937.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_903938.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine YP_903939.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_903940.1 KEGG: ilo:IL0747 hypothetical protein YP_903941.1 PFAM: MscS Mechanosensitive ion channel; KEGG: vfi:VFA0405 mechanosensitive ion channel YP_903942.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_903943.1 PFAM: electron transport protein SCO1/SenC; KEGG: rbe:RBE_0699 Sco2 protein precursor YP_903944.1 PFAM: protein of unknown function DUF461; KEGG: dar:Daro_1578 protein of unknown function DUF461 YP_903945.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_903946.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis YP_903947.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_903948.1 KEGG: pha:PSHAa0647 exodeoxyribonuclease VII large subunit; TIGRFAM: exodeoxyribonuclease VII, large subunit; PFAM: Exonuclease VII, large subunit; nucleic acid binding, OB-fold, tRNA/helicase-type YP_903949.1 PFAM: peptidase M23B; KEGG: psp:PSPPH_1330 peptidase, M23/M37 family YP_903950.1 PFAM: RDD domain containing protein; KEGG: nmu:Nmul_A1054 RDD YP_903952.1 PFAM: Septum formation initiator YP_903953.1 TIGRFAM: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; KEGG: vvy:VV2816 4-diphosphocytidyl-2-methyl-D-erithritol synthase YP_903954.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_903955.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_903956.1 KEGG: mfa:Mfla_2267 UDP-N-acetylenolpyruvoylglucosamine reductase; TIGRFAM: UDP-N-acetylenolpyruvoylglucosamine reductase; PFAM: FAD linked oxidase domain protein; UDP-N-acetylenolpyruvoylglucosamine reductase domain protein YP_903957.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_903958.1 KEGG: pfo:Pfl_4670 cell division protein FtsQ YP_903960.1 PFAM: Peptidoglycan-binding LysM; Lytic transglycosylase, catalytic; KEGG: cps:CPS_1998 putative membrane-bound lytic murein transglycosylase YP_903961.1 PFAM: BolA family protein; KEGG: pha:PSHAa2243 regulator protein YP_903962.1 PFAM: ferredoxin; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; Ferric reductase, NAD binding; KEGG: tbd:Tbd_2563 NAD(P)H-flavin reductase YP_903963.1 KEGG: vpa:VP2818 tRNA delta(2)-isopentenylpyrophosphate transferase; TIGRFAM: tRNA delta(2)-isopentenylpyrophosphate transferase; PFAM: tRNA isopentenyltransferase YP_903964.1 TIGRFAM: UDP-N-acetylmuramoylalanine--D-glutamate ligase; PFAM: cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG: noc:Noc_2863 UDP-N-acetylmuramoylalanine-D-glutamate ligase YP_903965.1 PFAM: protein of unknown function UPF0005; KEGG: tbd:Tbd_0489 hypothetical protein YP_903966.1 PFAM: NUDIX hydrolase; KEGG: sdn:Sden_2782 NUDIX hydrolase YP_903967.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_903968.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_903969.1 KEGG: xoo:XOO4599 hypothetical protein YP_903970.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide YP_903971.1 PFAM: Cl- channel, voltage-gated family protein; KEGG: rpa:RPA3953 putative chloride channel protein YP_903972.1 PFAM: conserved hypothetical protein 701; KEGG: hch:HCH_06247 predicted membrane protein YP_903974.1 KEGG: bur:Bcep18194_C6923 hypothetical protein YP_903975.1 PFAM: peptidase M16 domain protein; KEGG: tcx:Tcr_1940 peptidase M16-like YP_903976.1 PFAM: peptidase M16 domain protein; KEGG: mca:MCA0063 peptidase, M16 family YP_903977.1 KEGG: lpp:lpp2724 signal recognition particle receptor; TIGRFAM: signal recognition particle-docking protein FtsY; PFAM: GTP-binding signal recognition particle SRP54, G- domain; SMART: AAA ATPase YP_903979.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_903980.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_903981.1 TIGRFAM: methionyl-tRNA formyltransferase; PFAM: formyl transferase domain protein; KEGG: tcx:Tcr_0192 methionyl-tRNA formyltransferase YP_903982.1 PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: lpp:lpp2563 RNA methyltransferase TrmH family YP_903983.1 PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: tcx:Tcr_0414 AAA ATPase YP_903984.1 TIGRFAM: electron transport complex, RnfABCDGE type, E subunit; PFAM: RnfA-Nqr electron transport subunit; KEGG: tcx:Tcr_1031 electron transport complex, RnfABCDGE type, E subunit YP_903985.1 TIGRFAM: modification methylase, HemK family; PFAM: methyltransferase small; KEGG: tcx:Tcr_0388 modification methylase, HemK family YP_903986.1 TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha subunit; hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S type hydro-lyases tartrate/fumarate alpha region; Fe-S type hydro-lyases tartrate/fumarate beta region; KEGG: pha:PSHAa1166 fumarate hydratase, class I YP_903987.1 functions in MreBCD complex in some organisms YP_903988.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_903989.1 KEGG: pfo:Pfl_0840 rod shape-determining protein MreD YP_903990.1 PFAM: penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain; KEGG: pae:PA4003 penicillin-binding protein 2 YP_903991.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase; KEGG: rfr:Rfer_3493 ABC transporter related YP_903992.1 KEGG: vpa:VP0679 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase; TIGRFAM: riboflavin biosynthesis protein RibD; Riboflavin-specific deaminase-like; PFAM: CMP/dCMP deaminase, zinc-binding; bifunctional deaminase-reductase domain protein YP_903993.1 TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; PFAM: flavoprotein; DNA/pantothenate metabolism flavoprotein domain protein; KEGG: ilo:IL0239 phosphopantothenoylcysteine synthetase/decarboxylase YP_903995.1 KEGG: noc:Noc_0846 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP C-terminal domain protein; nucleic acid binding, OB-fold, tRNA/helicase-type; SMART: phosphoesterase PHP domain protein YP_903997.1 KEGG: tcx:Tcr_0601 sulfur oxidation protein SoxA YP_903998.1 KEGG: bja:bll1012 sulfur oxidation protein YP_903999.1 KEGG: tcx:Tcr_0603 sulfur oxidation protein SoxY-like YP_904000.1 KEGG: tbd:Tbd_0567 sulfur oxidation protein SoxX YP_904001.1 KEGG: noc:Noc_2494 anthranilate synthase component I; TIGRFAM: anthranilate synthase component I; PFAM: Anthranilate synthase component I and chorismate binding protein; Anthranilate synthase component I domain protein YP_904002.1 KEGG: lpf:lpl0363 RNA polymerase beta' subunit; TIGRFAM: DNA-directed RNA polymerase, beta' subunit; PFAM: RNA polymerase, alpha subunit; RNA polymerase Rpb1, domain 3; RNA polymerase Rpb1, domain 1; RNA polymerase Rpb1, domain 5; RNA polymerase Rpb1, domain 4; SMART: RNA polymerase I subunit A domain protein YP_904003.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_904004.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_904005.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_904006.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_904007.1 binds directly to 23S ribosomal RNA YP_904008.1 KEGG: tcx:Tcr_0283 NusG antitermination factor; TIGRFAM: transcription termination/antitermination factor NusG; PFAM: transcription antitermination protein NusG; SMART: NGN domain protein YP_904009.1 TIGRFAM: preprotein translocase, SecE subunit; PFAM: protein secE/sec61-gamma protein; KEGG: tbd:Tbd_0392 SecE subunit of protein translocation complex YP_904010.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_904011.1 PFAM: malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: hch:HCH_05974 malic enzyme YP_904012.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_904013.1 PFAM: histidine triad (HIT) protein; KEGG: csa:Csal_0911 histidine triad (HIT) protein YP_904014.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: tcx:Tcr_1381 sulfide-quinone reductase YP_904015.1 PFAM: nitroreductase; KEGG: reu:Reut_A1045 nitroreductase YP_904016.1 PFAM: beta-lactamase domain protein; KEGG: dre:405865 zgc:85680 YP_904017.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_904019.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_904020.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_904021.1 PFAM: OsmC family protein; KEGG: mfa:Mfla_0380 OsmC-like protein YP_904022.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_904023.1 PFAM: aminotransferase, class I and II; KEGG: pfl:PFL_5692 8-amino-7-oxononanoate synthase YP_904024.1 PFAM: alpha/beta hydrolase fold; KEGG: sdn:Sden_3530 BioH protein YP_904025.1 KEGG: tcx:Tcr_1819 phosphoribosylaminoimidazole carboxylase, catalytic subunit; TIGRFAM: phosphoribosylaminoimidazole carboxylase, catalytic subunit; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase YP_904026.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_904027.1 PFAM: glutaredoxin; KEGG: pha:PSHAa0634 glutaredoxin YP_904028.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_904029.1 KEGG: hdu:HD0334 3-deoxy-manno-octulosonate cytidylyltransferase; TIGRFAM: 3-deoxy-D-manno-octulosonate cytidylyltransferase; PFAM: acylneuraminate cytidylyltransferase YP_904030.1 PFAM: protein of unknown function DUF343; KEGG: tfu:Tfu_2509 hypothetical protein YP_904031.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_904032.1 TIGRFAM: lipoprotein releasing system, transmembrane protein, LolC/E family; PFAM: protein of unknown function DUF214; KEGG: mfa:Mfla_2095 lipoprotein releasing system, transmembrane protein, LolC/E family YP_904033.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: neu:NE1056 lipoprotein releasing system ATP-binding ABC transporter YP_904034.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_904035.1 KEGG: cps:CPS_1050 oxaloacetate decarboxylase, beta subunit; TIGRFAM: sodium ion-translocating decarboxylase, beta subunit; PFAM: Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit YP_904036.1 catalyzes the formation of pyruvate from oxaloacetate YP_904037.1 TIGRFAM: sodium pump decarboxylases, gamma subunit; PFAM: sodium pump decarboxylase, gamma subunit YP_904038.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_904039.1 KEGG: reu:Reut_A0215 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase YP_904041.1 PFAM: Uroporphyrinogen III synthase HEM4; KEGG: mca:MCA3061 uroporphyrinogen-III synthase/uroporphyrin-III C-methyltransferase YP_904043.1 TIGRFAM: Na+/Ca+ antiporter, CaCA family; PFAM: sodium/calcium exchanger membrane region; KEGG: tcx:Tcr_0977 K+-dependent Na+/Ca+ exchanger related-protein YP_904044.1 PFAM: protein of unknown function UPF0079; KEGG: msu:MS1514 predicted ATPase or kinase YP_904045.1 TIGRFAM: cobyrinic acid a,c-diamide synthase; PFAM: HesB/YadR/YfhF-family protein; Cobyrinic acid a,c-diamide synthase; CobB/CobQ domain protein glutamine amidotransferase; KEGG: tbd:Tbd_2473 cobyrinic acid a,c-diamide synthase CbiA YP_904046.1 PFAM: Polysulphide reductase, NrfD; KEGG: tbd:Tbd_2474 molybdopterin oxidoreductase, membrane subunit YP_904047.1 TIGRFAM: Twin-arginine translocation pathway signal; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: tbd:Tbd_2475 iron-sulfur cluster protein YP_904048.1 KEGG: mag:amb3376 Hdr-like menaquinol oxidoreductase cytochrome c subunit YP_904049.1 unknown function YP_904050.1 PFAM: protein of unknown function DUF224, cysteine-rich region domain protein; KEGG: tbd:Tbd_2478 reductase, iron-sulfur binding subunit, putative YP_904051.1 PFAM: Nitrate reductase, gamma subunit; KEGG: tbd:Tbd_2479 putative DsrM protein YP_904052.1 PFAM: DsrC family protein; KEGG: mag:amb3372 dissimilatory sulfite reductase YP_904053.1 PFAM: DsrH family protein; KEGG: tbd:Tbd_2481 DsrH protein YP_904054.1 PFAM: DsrE family protein; KEGG: mag:amb3370 uncharacterized protein involved in the oxidation of intracellular sulfur YP_904055.1 PFAM: DsrE family protein; KEGG: mag:amb3369 intracellular sulfur oxidation protein DsrE YP_904056.1 KEGG: tbd:Tbd_2484 sulfite reductase, dissimilatory-type beta subunit; TIGRFAM: sulfite reductase, dissimilatory-type beta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region YP_904057.1 KEGG: tbd:Tbd_2485 sulfite reductase, dissimilatory-type alpha subunit; TIGRFAM: sulfite reductase, dissimilatory-type alpha subunit; PFAM: nitrite and sulphite reductase 4Fe-4S region YP_904058.1 TIGRFAM: glutamate synthases, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: rba:RB5653 NADH-glutamate synthase small chain YP_904059.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_904060.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_904061.1 TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; RimK domain protein ATP-grasp; KEGG: noc:Noc_2572 carbamoyl-phosphate synthase, large subunit, glutamine-dependent YP_904062.1 PFAM: VacJ family lipoprotein; KEGG: noc:Noc_2787 VacJ-like lipoprotein YP_904063.1 TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase, small chain; KEGG: vfi:VF0472 carbamoyl-phosphate synthase small chain YP_904064.1 KEGG: tcx:Tcr_0383 heavy metal transport/detoxification protein YP_904065.1 TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: csa:Csal_3147 thiamine biosynthesis protein ThiS YP_904066.1 KEGG: noc:Noc_2654 hypothetical protein YP_904067.1 KEGG: vpa:VP1626 sulfite reductase, gamma subunit-related protein YP_904068.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_904069.1 TIGRFAM: glucosamine--fructose-6-phosphate aminotransferase, isomerizing; PFAM: glutamine amidotransferase, class-II; sugar isomerase (SIS); KEGG: tcx:Tcr_1692 glucosamine--fructose-6-phosphate aminotransferase, isomerizing YP_904070.1 catalyzes the formation of D-fructose 6-phosphate from D-glucose 6-phosphate YP_904071.1 TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: tdn:Tmden_1473 UTP--glucose-1-phosphate uridylyltransferase YP_904072.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain; KEGG: cps:CPS_0594 polysaccharide biosynthesis protein YP_904073.1 PFAM: sugar transferase; KEGG: dar:Daro_1277 sugar transferase YP_904074.1 PFAM: glycosyl transferase, family 2; KEGG: hpy:HP0102 hypothetical protein YP_904075.1 PFAM: glycosyl transferase, group 1; KEGG: dge:Dgeo_2669 glycosyl transferase, group 1 YP_904076.1 PFAM: glycosyl transferase, family 2; KEGG: hpy:HP0102 hypothetical protein YP_904077.1 KEGG: cpe:CPE0622 hypothetical protein YP_904078.1 TIGRFAM: cytidyltransferase-related domain; PFAM: Riboflavin kinase / FAD synthetase; cytidylyltransferase; KEGG: msu:MS0658 cytidylyltransferase YP_904079.1 KEGG: ava:Ava_1042 methyltransferase FkbM YP_904081.1 KEGG: pub:SAR11_0530 cyclopropane-fatty-acyl-phospholipid synthase (CMAS family) YP_904082.1 KEGG: pmi:PMT9312_1328 hypothetical protein YP_904083.1 KEGG: mth:MTH1523 glucose-1-phosphate adenylyltransferase related protein YP_904084.1 KEGG: lmf:LMOf2365_0663 hypothetical protein YP_904085.1 KEGG: aae:aq_2171 putative 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_904086.1 PFAM: polysaccharide biosynthesis protein; KEGG: cch:Cag_0665 probable polysaccharide biosynthesis protein YP_904087.1 PFAM: NAD-dependent epimerase/dehydratase; KEGG: dps:DP0023 probable GDP-L-fucose synthetase YP_904088.1 TIGRFAM: GDP-mannose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; KEGG: tbd:Tbd_1776 GDP-mannose 4,6-dehydratase YP_904089.1 KEGG: csa:Csal_1692 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase, type II; Nucleotidyl transferase; Cupin 2, conserved barrel domain protein YP_904090.1 KEGG: par:Psyc_1205 hypothetical protein YP_904091.1 PFAM: glycosyl transferase, family 25; KEGG: ppr:PBPRA0217 putative Lex2B protein (lipooligosaccharide 5G8 epitope biosynthesis-associated protein) YP_904092.1 PFAM: O-antigen polymerase; KEGG: hin:HI0874 hypothetical protein YP_904093.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_904094.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_904095.1 PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA YP_904096.1 PFAM: ATP-dependent Clp protease adaptor protein ClpS; KEGG: nha:Nham_2417 ATP-dependent Clp protease adaptor protein ClpS YP_904097.1 PFAM: permease YjgP/YjgQ family protein; KEGG: noc:Noc_1909 permease YjgP/YjgQ YP_904098.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_904099.1 PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: pha:PSHAa2333 tRNA-specific adenosine deaminase YP_904100.1 TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: short-chain dehydrogenase/reductase SDR; KEGG: tcx:Tcr_0712 3-oxoacyl-(acyl-carrier-protein) reductase YP_904101.1 TIGRFAM: malonyl CoA-acyl carrier protein transacylase; KEGG: tcx:Tcr_0711 malonyl CoA-acyl carrier protein transacylase YP_904102.1 involved in the peptidyltransferase reaction during translation YP_904103.1 PFAM: ribosomal protein L21; KEGG: pfo:Pfl_4860 ribosomal protein L21 YP_904104.1 PFAM: peptidyl-prolyl cis-trans isomerase, cyclophilin type; KEGG: ppu:PP2903 peptidyl-prolyl cis-trans isomerase B YP_904105.1 TIGRFAM: UDP-2,3-diacylglucosamine hydrolase; PFAM: metallophosphoesterase; KEGG: hdu:HD1938 UDP-2,3 diacylglucosamine hydrolase YP_904106.1 PFAM: ribonuclease II; KEGG: ftu:FTT0257 ribonuclease II family protein YP_904107.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_904108.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_904109.1 PFAM: Intracellular septation protein A; KEGG: mca:MCA1646 intracellular septation protein A YP_904111.1 TIGRFAM: putative endoribonuclease L-PSP; PFAM: Endoribonuclease L-PSP; KEGG: sde:Sde_3698 peptidase S1C, Do YP_904112.1 PFAM: helicase domain protein; nucleic acid binding, OB-fold, tRNA/helicase-type; DEAD/DEAH box helicase domain protein; KEGG: csa:Csal_3245 ATP-dependent DNA helicase RecG YP_904113.1 PFAM: Chorismate lyase; KEGG: pha:PSHAa2311 chorismate pyruvate lyase UbiC YP_904114.1 TIGRFAM: putative methyltransferase; PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: sbo:SBO_1132 hypothetical protein YP_904115.1 TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: hch:HCH_06126 anthranilate/para-aminobenzoate synthases component II YP_904116.1 PFAM: Rhodanese domain protein; KEGG: tbd:Tbd_2399 rhodanese-like protein YP_904117.1 PFAM: glutaredoxin; KEGG: wol:WD0758 glutaredoxin family protein YP_904118.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_904119.1 PFAM: ribosomal protein S9; KEGG: cps:CPS_4442 ribosomal protein S9 YP_904120.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_904121.1 PFAM: sulfatase; protein of unknown function DUF1705; KEGG: pfo:Pfl_3156 hypothetical protein YP_904122.1 PFAM: Redoxin domain protein; KEGG: tcx:Tcr_0234 hypothetical protein YP_904123.1 PFAM: helicase domain protein; DbpA, RNA-binding domain protein; DEAD/DEAH box helicase domain protein; KEGG: sde:Sde_3034 ATP-dependent RNA helicase DeaD YP_904124.1 PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein; KEGG: bca:BCE5298 cold shock protein CspC YP_904126.1 KEGG: ppr:PBPRA1693 putative exonuclease I; PFAM: Exonuclease, RNase T and DNA polymerase III; Exonuclease C-terminal domain protein; SMART: Exonuclease YP_904127.1 KEGG: tcx:Tcr_1030 endonuclease III; TIGRFAM: endonuclease III; PFAM: helix-hairpin-helix motif; HhH-GPD family protein; SMART: iron-sulfur cluster loop YP_904128.1 PFAM: aminoglycoside phosphotransferase; fructosamine kinase; KEGG: ath:At3g61080 fructosamine kinase family protein YP_904129.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_904130.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_904131.1 KEGG: tcx:Tcr_0800 aspartate-semialdehyde dehydrogenase, USG-1 related; TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, NAD - binding; Semialdehyde dehydrogenase, dimerisation region YP_904132.1 PFAM: protein of unknown function DUF34; KEGG: nmu:Nmul_A0806 protein of unknown function DUF34 YP_904133.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_904134.1 PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: ppu:PP4782 phosphomethylpyrimidine kinase YP_904135.1 PFAM: DSBA oxidoreductase; KEGG: mca:MCA2602 thiol:disulfide interchange protein DsbA YP_904136.1 TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: noc:Noc_0038 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HppK YP_904137.1 TIGRFAM: dihydroneopterin aldolase; KEGG: mca:MCA2988 dihydroneopterin aldolase YP_904138.1 PFAM: protein of unknown function DUF205; KEGG: tcx:Tcr_1811 protein of unknown function DUF205 YP_904139.1 PFAM: ABC-2 type transporter; KEGG: ppr:PBPRA3177 putative permease YP_904140.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: ilo:IL2259 ABC-type multidrug transport system, ATPase component YP_904141.1 PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: ftl:FTL_0310 pyruvate dehydrogenase, E2 component YP_904142.1 TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: tcx:Tcr_1003 dihydrolipoamide dehydrogenase YP_904143.1 PFAM: protein-L-isoaspartate(D-aspartate) O-methyltransferase; Methyltransferase type 11; KEGG: dar:Daro_3924 protein-L-isoaspartate(D-aspartate) O-methyltransferase:O-methyltransferase, family 3 YP_904144.1 KEGG: sde:Sde_3357 putative integral membrane protein YP_904145.1 KEGG: noc:Noc_2467 L-aspartate oxidase; TIGRFAM: L-aspartate oxidase; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_904146.1 KEGG: nma:NMA0164 polypeptide deformylase; TIGRFAM: peptide deformylase; PFAM: formylmethionine deformylase YP_904147.1 PFAM: helix-turn-helix, Fis-type; KEGG: mfa:Mfla_0350 helix-turn-helix, fis-type YP_904148.1 involved in de novo purine biosynthesis YP_904149.1 PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: csa:Csal_0021 5-formyltetrahydrofolate cyclo-ligase YP_904150.1 TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: monooxygenase, FAD-binding; KEGG: tcx:Tcr_1557 ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family YP_904151.1 PFAM: peptidase U62, modulator of DNA gyrase; KEGG: mca:MCA0383 PmbA protein YP_904152.1 KEGG: tcx:Tcr_0203 hypothetical protein YP_904153.1 PFAM: CBS domain containing protein; transporter-associated region; KEGG: hch:HCH_05351 putative Mg2+ and Co2+ transporter CorC YP_904154.1 PFAM: protein of unknown function UPF0125; KEGG: dar:Daro_2340 hypothetical protein YP_904155.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_904156.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: ilo:IL1434 lactoylglutathione lyase YP_904157.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_904158.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: pae:PA4461 probable ATP-binding component of ABC transporter YP_904159.1 TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin protein ligase domain protein; biotin/lipoate A/B protein ligase; KEGG: cbu:CBU_1002 birA bifunctional protein YP_904160.1 PFAM: diacylglycerol kinase; KEGG: hdu:HD1253 diacylglycerol kinase YP_904161.1 KEGG: pfo:Pfl_1896 pseudouridylate synthase; TIGRFAM: tRNA pseudouridine synthase A; PFAM: tRNA pseudouridine synthase YP_904162.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_904163.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: bur:Bcep18194_B0361 transcriptional regulator, LysR family YP_904164.1 PFAM: Citrate transporter; TrkA-C domain protein; KEGG: sru:SRU_1767 putative sodium-dependent transporter YP_904165.1 PFAM: carbonic anhydrase; KEGG: aci:ACIAD1056 putative carbonic anhydrase YP_904166.1 TIGRFAM: 16S rRNA processing protein RimM; PFAM: RimM protein; PRC-barrel domain protein; KEGG: noc:Noc_2259 16S rRNA processing protein RimM YP_904167.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_904168.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_904169.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_904170.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_904171.1 required for 70S ribosome assembly YP_904172.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_904173.1 KEGG: mca:MCA0321 exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase YP_904174.1 PFAM: putative methyltransferase; KEGG: lpf:lpl0521 S-adenosylmethionine-dependent methyltransferase YP_904175.1 PFAM: FxsA cytoplasmic membrane protein; KEGG: pha:PSHAa0261 F exclusion suppressor YP_904176.1 KEGG: mca:MCA2492 folylpolyglutamate synthase/dihydrofolate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase, middle domain protein YP_904177.1 KEGG: hch:HCH_02441 uncharacterized membrane protein, required for colicin V production YP_904178.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_904179.1 KEGG: noc:Noc_1151 O-succinylhomoserine sulfhydrylase; TIGRFAM: O-succinylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes YP_904180.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_904181.1 PFAM: beta-ketoacyl synthase; KEGG: tcx:Tcr_1945 beta-ketoacyl synthase YP_904182.1 TIGRFAM: protein-export membrane protein, SecD/SecF family; protein-export membrane protein SecF; PFAM: SecD/SecF/SecDF export membrane protein; KEGG: noc:Noc_2349 SecF protein YP_904183.1 TIGRFAM: protein-export membrane protein, SecD/SecF family; protein-export membrane protein SecD; PFAM: SecD/SecF/SecDF export membrane protein; KEGG: tcx:Tcr_1331 protein-export membrane protein SecD YP_904184.1 TIGRFAM: preprotein translocase, YajC subunit; PFAM: YajC family protein; KEGG: ftl:FTL_0847 preprotein translocase family protein YP_904185.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_904186.1 PFAM: Rhodanese domain protein; KEGG: vch:VCA0100 phage shock protein E YP_904187.1 KEGG: tbd:Tbd_2490 hypothetical protein YP_904188.1 PFAM: Rhodanese domain protein; KEGG: plt:Plut_0032 rhodanese-like YP_904189.1 PFAM: regulatory protein, LuxR; response regulator receiver; KEGG: hch:HCH_04021 response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain YP_904190.1 PFAM: GAF domain protein; ATP-binding region, ATPase domain protein domain protein; histidine kinase, dimerisation and phosphoacceptor region; KEGG: dar:Daro_0833 GAF:ATP-binding region, ATPase-like:histidine kinase, HAMP region:histidine kinase, dimerization and phosphoacceptor region YP_904191.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_904192.1 TIGRFAM: glutamate--cysteine ligase; KEGG: hch:HCH_06422 glutamate--cysteine ligase YP_904193.1 TIGRFAM: mutator MutT protein; PFAM: NUDIX hydrolase; thiamine monophosphate synthase; KEGG: noc:Noc_0306 mutator MutT YP_904194.1 PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: rba:RB5654 glutamate synthase [NADPH] large chain YP_904195.1 PFAM: dihydrofolate reductase region; KEGG: noc:Noc_0235 dihydrofolate reductase YP_904196.1 TIGRFAM: maf protein; PFAM: Maf family protein; KEGG: pha:PSHAa1813 Maf/Ham1 domain YP_904197.1 TIGRFAM: transcription-repair coupling factor; PFAM: helicase domain protein; transcription factor CarD; TRCF domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; KEGG: noc:Noc_1642 transcription-repair coupling factor YP_904198.1 PFAM: PfkB domain protein; KEGG: noc:Noc_2548 carbohydrate kinase, PfkB YP_904199.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_904200.1 TIGRFAM: acetyl-CoA carboxylase, carboxyl transferase, beta subunit; KEGG: csa:Csal_1263 acetyl-CoA carboxylase, carboxyl transferase, beta subunit YP_904201.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_904202.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_904203.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_904204.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; copper-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; E1-E2 ATPase-associated domain protein; KEGG: tcx:Tcr_1960 heavy metal translocating P-type ATPase YP_904206.1 KEGG: sde:Sde_3959 UDP-N-acetylglucosamine diphosphorylase; TIGRFAM: UDP-N-acetylglucosamine pyrophosphorylase; PFAM: transferase hexapeptide repeat containing protein; Nucleotidyl transferase YP_904207.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_904208.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis YP_904210.1 KEGG: tcx:Tcr_0196 DNA topoisomerase; TIGRFAM: DNA topoisomerase I; PFAM: TOPRIM domain protein; DNA topoisomerase, type IA, central domain protein; SMART: DNA topoisomerase I, ATP-binding; DNA topoisomerase I, DNA-binding; Toprim sub domain protein YP_904211.1 PFAM: protein of unknown function DUF494; KEGG: noc:Noc_3011 protein of unknown function DUF494 YP_904212.1 PFAM: ribosomal protein L34; KEGG: vvy:VV0005 ribosomal protein L34 YP_904213.1 TIGRFAM: ribonuclease P protein component; PFAM: ribonuclease P protein; KEGG: pha:PSHAa3025 ribonuclease P protein component (RNaseP protein) (RNase P protein) (protein C5) YP_904214.1 PFAM: protein of unknown function DUF37; KEGG: tcx:Tcr_1890 protein of unknown function DUF37 YP_904215.1 PFAM: 60 kDa inner membrane insertion protein; KEGG: tcx:Tcr_2197 60 kDa inner membrane insertion protein YP_904216.1 KEGG: tbd:Tbd_2491 hypothetical protein YP_904217.1 PFAM: N-acetylmuramoyl-L-alanine amidase, family 2; KEGG: aci:ACIAD0063 N-acetyl-anhydromuramyl-L-alanine amidase (regulates ampC) YP_904218.1 TIGRFAM: hydrolase, HAD-superfamily, subfamily IIIA; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; KEGG: noc:Noc_2789 phosphatase KdsC YP_904219.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_904220.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_904221.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_904222.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_904223.1 TIGRFAM: ATP synthase F1, delta subunit; PFAM: H+-transporting two-sector ATPase, delta (OSCP) subunit; KEGG: noc:Noc_3077 H+-transporting two-sector ATPase, delta (OSCP) subunit YP_904224.1 TIGRFAM: ATP synthase F0, B subunit; PFAM: H+-transporting two-sector ATPase, B/B' subunit; KEGG: ngo:NGO2146 F-type H+-transporting ATPase b chain YP_904225.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_904226.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_904227.1 KEGG: tcx:Tcr_2172 ATP synthase protein I YP_904228.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: tcx:Tcr_1170 sulfide-quinone reductase YP_904229.1 PFAM: ATP-NAD/AcoX kinase; KEGG: tcx:Tcr_0867 NAD(+) kinase YP_904230.1 PFAM: GrpE protein; KEGG: tcx:Tcr_0869 GrpE protein YP_904232.1 PFAM: cytochrome c biogenesis protein, transmembrane region; Thioredoxin domain; KEGG: tcx:Tcr_0446 protein-disulfide reductase YP_904233.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_904234.1 TIGRFAM: acetyl-CoA carboxylase, biotin carboxyl carrier protein; PFAM: biotin/lipoyl attachment domain-containing protein; KEGG: vpa:VP2880 acetyl-CoA carboxylase, biotin carboxyl carrier protein YP_904235.1 TIGRFAM: acetyl-CoA carboxylase, biotin carboxylase; PFAM: Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; RimK domain protein ATP-grasp; KEGG: hin:HI0972 biotin carboxylase YP_904236.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_904237.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors YP_904238.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate YP_904239.1 TIGRFAM: ubiquinone/menaquinone biosynthesis methyltransferases; PFAM: UbiE/COQ5 methyltransferase; Methyltransferase type 11; Methyltransferase type 12; KEGG: pha:PSHAa2926 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase / S-adenosylmethionine YP_904241.1 TIGRFAM: 2-polyprenylphenol 6-hydroxylase; PFAM: ABC-1 domain protein; KEGG: tcx:Tcr_0400 2-polyprenylphenol 6-hydroxylase YP_904242.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_904243.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_904244.1 TIGRFAM: GTP-binding protein YchF; PFAM: GTP-binding protein, HSR1-related; Protein of unknown function DUF933; KEGG: vvy:VV0924 predicted GTPase YP_904245.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_904246.1 PFAM: ribulose-phosphate 3-epimerase; KEGG: son:SO0292 ribulose-phosphate 3-epimerase YP_904247.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_904248.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_904249.1 KEGG: bba:Bd2932 hypothetical protein YP_904250.1 TIGRFAM: preprotein translocase, SecG subunit; PFAM: Preprotein translocase SecG subunit; KEGG: lpp:lpp2837 protein-export membrane protein SecG (preprotein translocase subunit) YP_904251.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate