-- dump date   	20140619_023814
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
537021000001	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
537021000002	Prophage antirepressor [Transcription]; Region: COG3617
537021000003	BRO family, N-terminal domain; Region: Bro-N; smart01040
537021000004	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
537021000005	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
537021000006	active site
537021000007	substrate binding site [chemical binding]; other site
537021000008	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
537021000009	DNA binding site [nucleotide binding]
537021000010	active site
537021000011	catalytic site [active]
537021000012	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
537021000013	VRR-NUC domain; Region: VRR_NUC; pfam08774
537021000014	potential frameshift: common BLAST hit: gi|315122937|ref|YP_004063426.1| SNF2 related protein
537021000015	DEAD-like helicases superfamily; Region: DEXDc; smart00487
537021000016	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
537021000017	ATP binding site [chemical binding]; other site
537021000018	putative Mg++ binding site [ion binding]; other site
537021000019	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
537021000020	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
537021000021	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
537021000022	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
537021000023	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
537021000024	active site
537021000025	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
537021000026	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
537021000027	active site
537021000028	catalytic residues [active]
537021000029	DNA binding site [nucleotide binding]
537021000030	Int/Topo IB signature motif; other site
537021000031	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
537021000032	malic enzyme; Reviewed; Region: PRK12862
537021000033	Malic enzyme, N-terminal domain; Region: malic; pfam00390
537021000034	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
537021000035	putative NAD(P) binding site [chemical binding]; other site
537021000036	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
537021000037	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
537021000038	Permease; Region: Permease; pfam02405
537021000039	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
537021000040	anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771
537021000041	Walker A/P-loop; other site
537021000042	ATP binding site [chemical binding]; other site
537021000043	Q-loop/lid; other site
537021000044	ABC transporter signature motif; other site
537021000045	Walker B; other site
537021000046	D-loop; other site
537021000047	H-loop/switch region; other site
537021000048	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
537021000049	mce related protein; Region: MCE; pfam02470
537021000050	Protein of unknown function (DUF330); Region: DUF330; cl01135
537021000051	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
537021000052	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
537021000053	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
537021000054	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
537021000055	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
537021000056	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
537021000057	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
537021000058	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
537021000059	DNA binding site [nucleotide binding]
537021000060	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
537021000061	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
537021000062	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
537021000063	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
537021000064	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
537021000065	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
537021000066	RPB12 interaction site [polypeptide binding]; other site
537021000067	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
537021000068	RPB3 interaction site [polypeptide binding]; other site
537021000069	RPB1 interaction site [polypeptide binding]; other site
537021000070	RPB11 interaction site [polypeptide binding]; other site
537021000071	RPB10 interaction site [polypeptide binding]; other site
537021000072	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
537021000073	peripheral dimer interface [polypeptide binding]; other site
537021000074	core dimer interface [polypeptide binding]; other site
537021000075	L10 interface [polypeptide binding]; other site
537021000076	L11 interface [polypeptide binding]; other site
537021000077	putative EF-Tu interaction site [polypeptide binding]; other site
537021000078	putative EF-G interaction site [polypeptide binding]; other site
537021000079	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
537021000080	23S rRNA interface [nucleotide binding]; other site
537021000081	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
537021000082	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
537021000083	mRNA/rRNA interface [nucleotide binding]; other site
537021000084	50S ribosomal protein L11; Region: L11_bact; TIGR01632
537021000085	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
537021000086	23S rRNA interface [nucleotide binding]; other site
537021000087	L7/L12 interface [polypeptide binding]; other site
537021000088	putative thiostrepton binding site; other site
537021000089	L25 interface [polypeptide binding]; other site
537021000090	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
537021000091	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
537021000092	putative homodimer interface [polypeptide binding]; other site
537021000093	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
537021000094	heterodimer interface [polypeptide binding]; other site
537021000095	homodimer interface [polypeptide binding]; other site
537021000096	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
537021000097	elongation factor Tu; Reviewed; Region: PRK00049
537021000098	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
537021000099	G1 box; other site
537021000100	GEF interaction site [polypeptide binding]; other site
537021000101	GTP/Mg2+ binding site [chemical binding]; other site
537021000102	Switch I region; other site
537021000103	G2 box; other site
537021000104	G3 box; other site
537021000105	Switch II region; other site
537021000106	G4 box; other site
537021000107	G5 box; other site
537021000108	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
537021000109	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
537021000110	Antibiotic Binding Site [chemical binding]; other site
537021000111	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
537021000112	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
537021000113	Ligand Binding Site [chemical binding]; other site
537021000114	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
537021000115	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
537021000116	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
537021000117	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
537021000118	catalytic residue [active]
537021000119	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
537021000120	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
537021000121	active site
537021000122	dimerization interface [polypeptide binding]; other site
537021000123	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
537021000124	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
537021000125	ATP-grasp domain; Region: ATP-grasp; pfam02222
537021000126	Squalene/phytoene synthase; Region: SQS_PSY; pfam00494
537021000127	substrate binding pocket [chemical binding]; other site
537021000128	substrate-Mg2+ binding site; other site
537021000129	aspartate-rich region 2; other site
537021000130	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
537021000131	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
537021000132	Walker A motif; other site
537021000133	ATP binding site [chemical binding]; other site
537021000134	Walker B motif; other site
537021000135	arginine finger; other site
537021000136	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
537021000137	Walker A motif; other site
537021000138	ATP binding site [chemical binding]; other site
537021000139	Walker B motif; other site
537021000140	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
537021000141	Uncharacterized conserved protein [Function unknown]; Region: COG2127
537021000142	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
537021000143	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
537021000144	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
537021000145	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
537021000146	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
537021000147	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
537021000148	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
537021000149	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
537021000150	substrate binding pocket [chemical binding]; other site
537021000151	membrane-bound complex binding site; other site
537021000152	hinge residues; other site
537021000153	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
537021000154	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
537021000155	conserved gate region; other site
537021000156	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
537021000157	dimer interface [polypeptide binding]; other site
537021000158	conserved gate region; other site
537021000159	putative PBP binding loops; other site
537021000160	ABC-ATPase subunit interface; other site
537021000161	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
537021000162	dimer interface [polypeptide binding]; other site
537021000163	conserved gate region; other site
537021000164	putative PBP binding loops; other site
537021000165	ABC-ATPase subunit interface; other site
537021000166	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
537021000167	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
537021000168	Walker A/P-loop; other site
537021000169	ATP binding site [chemical binding]; other site
537021000170	Q-loop/lid; other site
537021000171	ABC transporter signature motif; other site
537021000172	Walker B; other site
537021000173	D-loop; other site
537021000174	H-loop/switch region; other site
537021000175	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
537021000176	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
537021000177	lipoate-protein ligase B; Provisional; Region: PRK14341
537021000178	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
537021000179	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
537021000180	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
537021000181	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
537021000182	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
537021000183	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
537021000184	active site
537021000185	nucleotide binding site [chemical binding]; other site
537021000186	HIGH motif; other site
537021000187	KMSKS motif; other site
537021000188	DNA gyrase subunit A; Validated; Region: PRK05560
537021000189	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
537021000190	CAP-like domain; other site
537021000191	active site
537021000192	primary dimer interface [polypeptide binding]; other site
537021000193	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
537021000194	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
537021000195	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
537021000196	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
537021000197	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
537021000198	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
537021000199	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
537021000200	dimer interface [polypeptide binding]; other site
537021000201	ssDNA binding site [nucleotide binding]; other site
537021000202	tetramer (dimer of dimers) interface [polypeptide binding]; other site
537021000203	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
537021000204	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
537021000205	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
537021000206	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
537021000207	glutamine synthetase, type I; Region: GlnA; TIGR00653
537021000208	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
537021000209	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
537021000210	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
537021000211	glutaminase; Provisional; Region: PRK00971
537021000212	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
537021000213	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
537021000214	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
537021000215	RNA binding surface [nucleotide binding]; other site
537021000216	fumarate hydratase; Reviewed; Region: fumC; PRK00485
537021000217	Class II fumarases; Region: Fumarase_classII; cd01362
537021000218	active site
537021000219	tetramer interface [polypeptide binding]; other site
537021000220	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
537021000221	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
537021000222	motif 1; other site
537021000223	active site
537021000224	motif 2; other site
537021000225	motif 3; other site
537021000226	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
537021000227	recombinase A; Provisional; Region: recA; PRK09354
537021000228	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
537021000229	hexamer interface [polypeptide binding]; other site
537021000230	Walker A motif; other site
537021000231	ATP binding site [chemical binding]; other site
537021000232	Walker B motif; other site
537021000233	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
537021000234	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
537021000235	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
537021000236	Walker A/P-loop; other site
537021000237	ATP binding site [chemical binding]; other site
537021000238	Q-loop/lid; other site
537021000239	ABC transporter signature motif; other site
537021000240	Walker B; other site
537021000241	D-loop; other site
537021000242	H-loop/switch region; other site
537021000243	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
537021000244	CTP synthetase; Validated; Region: pyrG; PRK05380
537021000245	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
537021000246	Catalytic site [active]
537021000247	active site
537021000248	UTP binding site [chemical binding]; other site
537021000249	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
537021000250	active site
537021000251	putative oxyanion hole; other site
537021000252	catalytic triad [active]
537021000253	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
537021000254	triosephosphate isomerase; Provisional; Region: PRK14565
537021000255	substrate binding site [chemical binding]; other site
537021000256	dimer interface [polypeptide binding]; other site
537021000257	catalytic triad [active]
537021000258	ferrochelatase; Reviewed; Region: hemH; PRK00035
537021000259	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
537021000260	C-terminal domain interface [polypeptide binding]; other site
537021000261	active site
537021000262	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
537021000263	active site
537021000264	N-terminal domain interface [polypeptide binding]; other site
537021000265	Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754
537021000266	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
537021000267	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
537021000268	FeS/SAM binding site; other site
537021000269	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
537021000270	UbiA prenyltransferase family; Region: UbiA; pfam01040
537021000271	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
537021000272	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
537021000273	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
537021000274	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
537021000275	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
537021000276	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
537021000277	catalytic triad [active]
537021000278	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
537021000279	putative hydrolase; Provisional; Region: PRK02113
537021000280	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
537021000281	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
537021000282	active site
537021000283	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
537021000284	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
537021000285	active site
537021000286	HIGH motif; other site
537021000287	KMSKS motif; other site
537021000288	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
537021000289	tRNA binding surface [nucleotide binding]; other site
537021000290	anticodon binding site; other site
537021000291	DNA polymerase III subunit delta'; Validated; Region: PRK09112
537021000292	DNA polymerase III subunit delta'; Validated; Region: PRK08485
537021000293	thymidylate kinase; Validated; Region: tmk; PRK00698
537021000294	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
537021000295	TMP-binding site; other site
537021000296	ATP-binding site [chemical binding]; other site
537021000297	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
537021000298	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
537021000299	ATP binding site [chemical binding]; other site
537021000300	Mg2+ binding site [ion binding]; other site
537021000301	G-X-G motif; other site
537021000302	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
537021000303	anchoring element; other site
537021000304	dimer interface [polypeptide binding]; other site
537021000305	ATP binding site [chemical binding]; other site
537021000306	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
537021000307	active site
537021000308	metal binding site [ion binding]; metal-binding site
537021000309	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
537021000310	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
537021000311	Domain of unknown function DUF20; Region: UPF0118; pfam01594
537021000312	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
537021000313	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
537021000314	putative active site [active]
537021000315	catalytic residue [active]
537021000316	GTP-binding protein YchF; Reviewed; Region: PRK09601
537021000317	YchF GTPase; Region: YchF; cd01900
537021000318	G1 box; other site
537021000319	GTP/Mg2+ binding site [chemical binding]; other site
537021000320	Switch I region; other site
537021000321	G2 box; other site
537021000322	Switch II region; other site
537021000323	G3 box; other site
537021000324	G4 box; other site
537021000325	G5 box; other site
537021000326	Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071
537021000327	pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555
537021000328	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
537021000329	active site
537021000330	ADP/pyrophosphate binding site [chemical binding]; other site
537021000331	allosteric effector site; other site
537021000332	dimerization interface [polypeptide binding]; other site
537021000333	fructose-1,6-bisphosphate binding site; other site
537021000334	hypothetical protein; Provisional; Region: PRK14013
537021000335	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
537021000336	Part of AAA domain; Region: AAA_19; pfam13245
537021000337	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
537021000338	AAA domain; Region: AAA_12; pfam13087
537021000339	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
537021000340	putative active site [active]
537021000341	YGGT family; Region: YGGT; pfam02325
537021000342	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
537021000343	dimer interface [polypeptide binding]; other site
537021000344	substrate binding site [chemical binding]; other site
537021000345	metal binding sites [ion binding]; metal-binding site
537021000346	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
537021000347	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
537021000348	G1 box; other site
537021000349	putative GEF interaction site [polypeptide binding]; other site
537021000350	GTP/Mg2+ binding site [chemical binding]; other site
537021000351	Switch I region; other site
537021000352	G2 box; other site
537021000353	G3 box; other site
537021000354	Switch II region; other site
537021000355	G4 box; other site
537021000356	G5 box; other site
537021000357	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
537021000358	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
537021000359	argininosuccinate synthase; Provisional; Region: PRK13820
537021000360	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
537021000361	ANP binding site [chemical binding]; other site
537021000362	Substrate Binding Site II [chemical binding]; other site
537021000363	Substrate Binding Site I [chemical binding]; other site
537021000364	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
537021000365	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
537021000366	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
537021000367	alphaNTD - beta interaction site [polypeptide binding]; other site
537021000368	alphaNTD homodimer interface [polypeptide binding]; other site
537021000369	alphaNTD - beta' interaction site [polypeptide binding]; other site
537021000370	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
537021000371	30S ribosomal protein S11; Validated; Region: PRK05309
537021000372	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
537021000373	30S ribosomal protein S13; Region: bact_S13; TIGR03631
537021000374	adenylate kinase; Reviewed; Region: adk; PRK00279
537021000375	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
537021000376	AMP-binding site [chemical binding]; other site
537021000377	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
537021000378	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
537021000379	SecY translocase; Region: SecY; pfam00344
537021000380	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
537021000381	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
537021000382	23S rRNA binding site [nucleotide binding]; other site
537021000383	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
537021000384	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
537021000385	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
537021000386	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
537021000387	23S rRNA interface [nucleotide binding]; other site
537021000388	L21e interface [polypeptide binding]; other site
537021000389	5S rRNA interface [nucleotide binding]; other site
537021000390	L27 interface [polypeptide binding]; other site
537021000391	L5 interface [polypeptide binding]; other site
537021000392	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
537021000393	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
537021000394	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
537021000395	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
537021000396	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
537021000397	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
537021000398	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
537021000399	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
537021000400	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
537021000401	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
537021000402	RNA binding site [nucleotide binding]; other site
537021000403	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
537021000404	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
537021000405	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
537021000406	23S rRNA interface [nucleotide binding]; other site
537021000407	putative translocon interaction site; other site
537021000408	signal recognition particle (SRP54) interaction site; other site
537021000409	L23 interface [polypeptide binding]; other site
537021000410	trigger factor interaction site; other site
537021000411	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
537021000412	23S rRNA interface [nucleotide binding]; other site
537021000413	5S rRNA interface [nucleotide binding]; other site
537021000414	putative antibiotic binding site [chemical binding]; other site
537021000415	L25 interface [polypeptide binding]; other site
537021000416	L27 interface [polypeptide binding]; other site
537021000417	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
537021000418	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
537021000419	G-X-X-G motif; other site
537021000420	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
537021000421	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
537021000422	putative translocon binding site; other site
537021000423	protein-rRNA interface [nucleotide binding]; other site
537021000424	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
537021000425	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
537021000426	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
537021000427	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
537021000428	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
537021000429	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
537021000430	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
537021000431	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
537021000432	elongation factor Tu; Reviewed; Region: PRK00049
537021000433	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
537021000434	G1 box; other site
537021000435	GEF interaction site [polypeptide binding]; other site
537021000436	GTP/Mg2+ binding site [chemical binding]; other site
537021000437	Switch I region; other site
537021000438	G2 box; other site
537021000439	G3 box; other site
537021000440	Switch II region; other site
537021000441	G4 box; other site
537021000442	G5 box; other site
537021000443	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
537021000444	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
537021000445	Antibiotic Binding Site [chemical binding]; other site
537021000446	elongation factor G; Reviewed; Region: PRK00007
537021000447	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
537021000448	G1 box; other site
537021000449	putative GEF interaction site [polypeptide binding]; other site
537021000450	GTP/Mg2+ binding site [chemical binding]; other site
537021000451	Switch I region; other site
537021000452	G2 box; other site
537021000453	G3 box; other site
537021000454	Switch II region; other site
537021000455	G4 box; other site
537021000456	G5 box; other site
537021000457	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
537021000458	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
537021000459	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
537021000460	30S ribosomal protein S7; Validated; Region: PRK05302
537021000461	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
537021000462	S17 interaction site [polypeptide binding]; other site
537021000463	S8 interaction site; other site
537021000464	16S rRNA interaction site [nucleotide binding]; other site
537021000465	streptomycin interaction site [chemical binding]; other site
537021000466	23S rRNA interaction site [nucleotide binding]; other site
537021000467	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
537021000468	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
537021000469	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
537021000470	carboxyltransferase (CT) interaction site; other site
537021000471	biotinylation site [posttranslational modification]; other site
537021000472	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
537021000473	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
537021000474	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
537021000475	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
537021000476	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
537021000477	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
537021000478	Found in ATP-dependent protease La (LON); Region: LON; smart00464
537021000479	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
537021000480	Walker A motif; other site
537021000481	ATP binding site [chemical binding]; other site
537021000482	Walker B motif; other site
537021000483	arginine finger; other site
537021000484	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
537021000485	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
537021000486	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
537021000487	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
537021000488	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
537021000489	Walker A motif; other site
537021000490	ATP binding site [chemical binding]; other site
537021000491	Walker B motif; other site
537021000492	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
537021000493	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
537021000494	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
537021000495	oligomer interface [polypeptide binding]; other site
537021000496	active site residues [active]
537021000497	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
537021000498	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
537021000499	Walker A/P-loop; other site
537021000500	ATP binding site [chemical binding]; other site
537021000501	Q-loop/lid; other site
537021000502	ABC transporter signature motif; other site
537021000503	Walker B; other site
537021000504	D-loop; other site
537021000505	H-loop/switch region; other site
537021000506	ABC transporter; Region: ABC_tran_2; pfam12848
537021000507	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
537021000508	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
537021000509	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
537021000510	SmpB-tmRNA interface; other site
537021000511	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
537021000512	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
537021000513	dimer interface [polypeptide binding]; other site
537021000514	active site
537021000515	catalytic residue [active]
537021000516	DNA polymerase I; Provisional; Region: PRK05755
537021000517	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
537021000518	active site
537021000519	metal binding site 1 [ion binding]; metal-binding site
537021000520	putative 5' ssDNA interaction site; other site
537021000521	metal binding site 3; metal-binding site
537021000522	metal binding site 2 [ion binding]; metal-binding site
537021000523	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
537021000524	putative DNA binding site [nucleotide binding]; other site
537021000525	putative metal binding site [ion binding]; other site
537021000526	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
537021000527	active site
537021000528	substrate binding site [chemical binding]; other site
537021000529	catalytic site [active]
537021000530	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
537021000531	active site
537021000532	DNA binding site [nucleotide binding]
537021000533	catalytic site [active]
537021000534	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
537021000535	catalytic core [active]
537021000536	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
537021000537	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
537021000538	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
537021000539	glucokinase; Provisional; Region: glk; PRK00292
537021000540	glucokinase, proteobacterial type; Region: glk; TIGR00749
537021000541	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
537021000542	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
537021000543	Cu(I) binding site [ion binding]; other site
537021000544	Transcriptional regulator [Transcription]; Region: LysR; COG0583
537021000545	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
537021000546	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
537021000547	putative effector binding pocket; other site
537021000548	dimerization interface [polypeptide binding]; other site
537021000549	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
537021000550	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
537021000551	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
537021000552	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
537021000553	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
537021000554	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
537021000555	active site
537021000556	HIGH motif; other site
537021000557	KMSK motif region; other site
537021000558	tRNA binding surface [nucleotide binding]; other site
537021000559	DALR anticodon binding domain; Region: DALR_1; smart00836
537021000560	anticodon binding site; other site
537021000561	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
537021000562	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
537021000563	Zn2+ binding site [ion binding]; other site
537021000564	Mg2+ binding site [ion binding]; other site
537021000565	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
537021000566	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
537021000567	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
537021000568	putative catalytic site [active]
537021000569	putative phosphate binding site [ion binding]; other site
537021000570	active site
537021000571	metal binding site A [ion binding]; metal-binding site
537021000572	DNA binding site [nucleotide binding]
537021000573	putative AP binding site [nucleotide binding]; other site
537021000574	putative metal binding site B [ion binding]; other site
537021000575	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
537021000576	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
537021000577	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
537021000578	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
537021000579	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
537021000580	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
537021000581	DNA binding residues [nucleotide binding]
537021000582	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
537021000583	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
537021000584	NAD(P) binding site [chemical binding]; other site
537021000585	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
537021000586	23S rRNA interface [nucleotide binding]; other site
537021000587	L3 interface [polypeptide binding]; other site
537021000588	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
537021000589	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
537021000590	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
537021000591	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
537021000592	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
537021000593	dimerization interface 3.5A [polypeptide binding]; other site
537021000594	active site
537021000595	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
537021000596	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
537021000597	putative active site [active]
537021000598	substrate binding site [chemical binding]; other site
537021000599	putative cosubstrate binding site; other site
537021000600	catalytic site [active]
537021000601	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
537021000602	substrate binding site [chemical binding]; other site
537021000603	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
537021000604	active site
537021000605	catalytic residues [active]
537021000606	metal binding site [ion binding]; metal-binding site
537021000607	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
537021000608	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
537021000609	active site
537021000610	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
537021000611	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
537021000612	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
537021000613	dihydroorotase; Validated; Region: PRK09059
537021000614	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
537021000615	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
537021000616	active site
537021000617	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
537021000618	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
537021000619	DNA protecting protein DprA; Region: dprA; TIGR00732
537021000620	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
537021000621	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
537021000622	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
537021000623	active site
537021000624	interdomain interaction site; other site
537021000625	putative metal-binding site [ion binding]; other site
537021000626	nucleotide binding site [chemical binding]; other site
537021000627	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
537021000628	domain I; other site
537021000629	DNA binding groove [nucleotide binding]
537021000630	phosphate binding site [ion binding]; other site
537021000631	domain II; other site
537021000632	domain III; other site
537021000633	nucleotide binding site [chemical binding]; other site
537021000634	catalytic site [active]
537021000635	domain IV; other site
537021000636	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
537021000637	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
537021000638	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
537021000639	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
537021000640	Transglycosylase SLT domain; Region: SLT_2; pfam13406
537021000641	murein hydrolase B; Provisional; Region: PRK10760; cl17906
537021000642	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
537021000643	active site
537021000644	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
537021000645	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
537021000646	catalytic triad [active]
537021000647	dimer interface [polypeptide binding]; other site
537021000648	Response regulator receiver domain; Region: Response_reg; pfam00072
537021000649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
537021000650	active site
537021000651	phosphorylation site [posttranslational modification]
537021000652	intermolecular recognition site; other site
537021000653	dimerization interface [polypeptide binding]; other site
537021000654	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
537021000655	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
537021000656	Porin subfamily; Region: Porin_2; pfam02530
537021000657	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
537021000658	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
537021000659	putative tRNA-binding site [nucleotide binding]; other site
537021000660	B3/4 domain; Region: B3_4; pfam03483
537021000661	tRNA synthetase B5 domain; Region: B5; smart00874
537021000662	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
537021000663	dimer interface [polypeptide binding]; other site
537021000664	motif 1; other site
537021000665	motif 3; other site
537021000666	motif 2; other site
537021000667	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
537021000668	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
537021000669	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
537021000670	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
537021000671	dimer interface [polypeptide binding]; other site
537021000672	motif 1; other site
537021000673	active site
537021000674	motif 2; other site
537021000675	motif 3; other site
537021000676	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
537021000677	23S rRNA binding site [nucleotide binding]; other site
537021000678	L21 binding site [polypeptide binding]; other site
537021000679	L13 binding site [polypeptide binding]; other site
537021000680	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
537021000681	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
537021000682	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
537021000683	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
537021000684	GTP-binding protein LepA; Provisional; Region: PRK05433
537021000685	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
537021000686	G1 box; other site
537021000687	putative GEF interaction site [polypeptide binding]; other site
537021000688	GTP/Mg2+ binding site [chemical binding]; other site
537021000689	Switch I region; other site
537021000690	G2 box; other site
537021000691	G3 box; other site
537021000692	Switch II region; other site
537021000693	G4 box; other site
537021000694	G5 box; other site
537021000695	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
537021000696	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
537021000697	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
537021000698	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
537021000699	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
537021000700	TLC ATP/ADP transporter; Region: TLC; pfam03219
537021000701	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
537021000702	active site
537021000703	8-oxo-dGMP binding site [chemical binding]; other site
537021000704	nudix motif; other site
537021000705	metal binding site [ion binding]; metal-binding site
537021000706	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
537021000707	heterotetramer interface [polypeptide binding]; other site
537021000708	active site pocket [active]
537021000709	cleavage site
537021000710	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
537021000711	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
537021000712	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
537021000713	SEC-C motif; Region: SEC-C; pfam02810
537021000714	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
537021000715	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
537021000716	NAD binding site [chemical binding]; other site
537021000717	homodimer interface [polypeptide binding]; other site
537021000718	active site
537021000719	substrate binding site [chemical binding]; other site
537021000720	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
537021000721	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
537021000722	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
537021000723	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
537021000724	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
537021000725	replicative DNA helicase; Provisional; Region: PRK09165
537021000726	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
537021000727	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
537021000728	Walker A motif; other site
537021000729	ATP binding site [chemical binding]; other site
537021000730	Walker B motif; other site
537021000731	DNA binding loops [nucleotide binding]
537021000732	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
537021000733	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
537021000734	active site
537021000735	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
537021000736	dimer interface [polypeptide binding]; other site
537021000737	substrate binding site [chemical binding]; other site
537021000738	catalytic residues [active]
537021000739	DNA repair protein RadA; Provisional; Region: PRK11823
537021000740	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
537021000741	Walker A motif; other site
537021000742	ATP binding site [chemical binding]; other site
537021000743	Walker B motif; other site
537021000744	Colicin V production protein; Region: Colicin_V; pfam02674
537021000745	amidophosphoribosyltransferase; Provisional; Region: PRK09123
537021000746	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
537021000747	active site
537021000748	tetramer interface [polypeptide binding]; other site
537021000749	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
537021000750	active site
537021000751	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
537021000752	classical (c) SDRs; Region: SDR_c; cd05233
537021000753	NAD(P) binding site [chemical binding]; other site
537021000754	active site
537021000755	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
537021000756	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
537021000757	Walker A/P-loop; other site
537021000758	ATP binding site [chemical binding]; other site
537021000759	Q-loop/lid; other site
537021000760	ABC transporter signature motif; other site
537021000761	Walker B; other site
537021000762	D-loop; other site
537021000763	H-loop/switch region; other site
537021000764	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
537021000765	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
537021000766	dimer interface [polypeptide binding]; other site
537021000767	conserved gate region; other site
537021000768	putative PBP binding loops; other site
537021000769	ABC-ATPase subunit interface; other site
537021000770	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
537021000771	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
537021000772	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
537021000773	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
537021000774	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
537021000775	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
537021000776	putative RNA binding site [nucleotide binding]; other site
537021000777	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
537021000778	homopentamer interface [polypeptide binding]; other site
537021000779	active site
537021000780	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
537021000781	Lumazine binding domain; Region: Lum_binding; pfam00677
537021000782	Lumazine binding domain; Region: Lum_binding; pfam00677
537021000783	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
537021000784	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
537021000785	catalytic motif [active]
537021000786	Zn binding site [ion binding]; other site
537021000787	RibD C-terminal domain; Region: RibD_C; cl17279
537021000788	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
537021000789	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
537021000790	dimer interface [polypeptide binding]; other site
537021000791	active site
537021000792	glycine-pyridoxal phosphate binding site [chemical binding]; other site
537021000793	folate binding site [chemical binding]; other site
537021000794	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
537021000795	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
537021000796	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
537021000797	Transcriptional regulators [Transcription]; Region: MarR; COG1846
537021000798	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
537021000799	dimer interface [polypeptide binding]; other site
537021000800	allosteric magnesium binding site [ion binding]; other site
537021000801	active site
537021000802	aspartate-rich active site metal binding site; other site
537021000803	Schiff base residues; other site
537021000804	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
537021000805	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
537021000806	CAP-like domain; other site
537021000807	active site
537021000808	primary dimer interface [polypeptide binding]; other site
537021000809	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
537021000810	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
537021000811	dimer interface [polypeptide binding]; other site
537021000812	active site
537021000813	citrylCoA binding site [chemical binding]; other site
537021000814	NADH binding [chemical binding]; other site
537021000815	cationic pore residues; other site
537021000816	oxalacetate/citrate binding site [chemical binding]; other site
537021000817	coenzyme A binding site [chemical binding]; other site
537021000818	catalytic triad [active]
537021000819	Competence protein; Region: Competence; pfam03772
537021000820	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
537021000821	nucleoside/Zn binding site; other site
537021000822	dimer interface [polypeptide binding]; other site
537021000823	catalytic motif [active]
537021000824	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
537021000825	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
537021000826	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
537021000827	UbiA prenyltransferase family; Region: UbiA; pfam01040
537021000828	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
537021000829	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
537021000830	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
537021000831	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
537021000832	FAD binding pocket [chemical binding]; other site
537021000833	FAD binding motif [chemical binding]; other site
537021000834	phosphate binding motif [ion binding]; other site
537021000835	beta-alpha-beta structure motif; other site
537021000836	NAD binding pocket [chemical binding]; other site
537021000837	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
537021000838	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
537021000839	FAD binding pocket [chemical binding]; other site
537021000840	FAD binding motif [chemical binding]; other site
537021000841	phosphate binding motif [ion binding]; other site
537021000842	beta-alpha-beta structure motif; other site
537021000843	NAD binding pocket [chemical binding]; other site
537021000844	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
537021000845	active site
537021000846	tetramer interface; other site
537021000847	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
537021000848	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
537021000849	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
537021000850	Ligand binding site [chemical binding]; other site
537021000851	Electron transfer flavoprotein domain; Region: ETF; pfam01012
537021000852	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
537021000853	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
537021000854	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
537021000855	argininosuccinate lyase; Provisional; Region: PRK00855
537021000856	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
537021000857	active sites [active]
537021000858	tetramer interface [polypeptide binding]; other site
537021000859	diaminopimelate decarboxylase; Region: lysA; TIGR01048
537021000860	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
537021000861	active site
537021000862	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
537021000863	substrate binding site [chemical binding]; other site
537021000864	catalytic residues [active]
537021000865	dimer interface [polypeptide binding]; other site
537021000866	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
537021000867	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
537021000868	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
537021000869	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
537021000870	Uncharacterized conserved protein [Function unknown]; Region: COG3334
537021000871	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
537021000872	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
537021000873	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
537021000874	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
537021000875	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
537021000876	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
537021000877	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
537021000878	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
537021000879	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
537021000880	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
537021000881	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
537021000882	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
537021000883	ATP binding site [chemical binding]; other site
537021000884	Mg++ binding site [ion binding]; other site
537021000885	motif III; other site
537021000886	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
537021000887	nucleotide binding region [chemical binding]; other site
537021000888	ATP-binding site [chemical binding]; other site
537021000889	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
537021000890	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
537021000891	minor groove reading motif; other site
537021000892	helix-hairpin-helix signature motif; other site
537021000893	substrate binding pocket [chemical binding]; other site
537021000894	active site
537021000895	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
537021000896	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
537021000897	active site
537021000898	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
537021000899	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
537021000900	Walker A/P-loop; other site
537021000901	ATP binding site [chemical binding]; other site
537021000902	Q-loop/lid; other site
537021000903	ABC transporter signature motif; other site
537021000904	Walker B; other site
537021000905	D-loop; other site
537021000906	H-loop/switch region; other site
537021000907	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
537021000908	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
537021000909	HlyD family secretion protein; Region: HlyD_3; pfam13437
537021000910	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
537021000911	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
537021000912	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA_subfamily_ECM; cd01450
537021000913	metal ion-dependent adhesion site (MIDAS); other site
537021000914	integrin-collagen binding site; other site
537021000915	integrin inhibitor binding pocket; other site
537021000916	putative vWF-collagen binding site; other site
537021000917	glycoprotein Ib (GpIb) binding site [polypeptide binding]; other site
537021000918	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
537021000919	active site
537021000920	multimer interface [polypeptide binding]; other site
537021000921	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
537021000922	multifunctional aminopeptidase A; Provisional; Region: PRK00913
537021000923	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
537021000924	interface (dimer of trimers) [polypeptide binding]; other site
537021000925	Substrate-binding/catalytic site; other site
537021000926	Zn-binding sites [ion binding]; other site
537021000927	Predicted permeases [General function prediction only]; Region: COG0795
537021000928	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
537021000929	Predicted permeases [General function prediction only]; Region: COG0795
537021000930	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
537021000931	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
537021000932	Organic solvent tolerance protein; Region: OstA_C; pfam04453
537021000933	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
537021000934	SurA N-terminal domain; Region: SurA_N; pfam09312
537021000935	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
537021000936	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
537021000937	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
537021000938	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
537021000939	S-adenosylmethionine binding site [chemical binding]; other site
537021000940	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
537021000941	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
537021000942	ATP binding site [chemical binding]; other site
537021000943	Mg2+ binding site [ion binding]; other site
537021000944	G-X-G motif; other site
537021000945	DNA mismatch repair protein, C-terminal domain; Region: DNA_mis_repair; pfam01119
537021000946	ATP binding site [chemical binding]; other site
537021000947	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
537021000948	Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; cl11535
537021000949	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
537021000950	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
537021000951	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
537021000952	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
537021000953	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
537021000954	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
537021000955	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
537021000956	active site
537021000957	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
537021000958	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
537021000959	S-adenosylmethionine binding site [chemical binding]; other site
537021000960	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
537021000961	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
537021000962	RNA binding surface [nucleotide binding]; other site
537021000963	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
537021000964	active site
537021000965	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
537021000966	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
537021000967	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
537021000968	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
537021000969	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
537021000970	active site
537021000971	Uncharacterized conserved protein [Function unknown]; Region: COG1565
537021000972	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
537021000973	Membrane fusogenic activity; Region: BMFP; pfam04380
537021000974	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
537021000975	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
537021000976	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
537021000977	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
537021000978	dimer interface [polypeptide binding]; other site
537021000979	phosphorylation site [posttranslational modification]
537021000980	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
537021000981	ATP binding site [chemical binding]; other site
537021000982	Mg2+ binding site [ion binding]; other site
537021000983	G-X-G motif; other site
537021000984	GMP synthase; Reviewed; Region: guaA; PRK00074
537021000985	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
537021000986	AMP/PPi binding site [chemical binding]; other site
537021000987	candidate oxyanion hole; other site
537021000988	catalytic triad [active]
537021000989	potential glutamine specificity residues [chemical binding]; other site
537021000990	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
537021000991	ATP Binding subdomain [chemical binding]; other site
537021000992	Ligand Binding sites [chemical binding]; other site
537021000993	Dimerization subdomain; other site
537021000994	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
537021000995	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
537021000996	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
537021000997	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
537021000998	Transporter associated domain; Region: CorC_HlyC; smart01091
537021000999	Ferredoxin [Energy production and conversion]; Region: COG1146
537021001000	4Fe-4S binding domain; Region: Fer4; pfam00037
537021001001	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
537021001002	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
537021001003	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
537021001004	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
537021001005	5S rRNA interface [nucleotide binding]; other site
537021001006	CTC domain interface [polypeptide binding]; other site
537021001007	L16 interface [polypeptide binding]; other site
537021001008	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
537021001009	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
537021001010	dimer interface [polypeptide binding]; other site
537021001011	anticodon binding site; other site
537021001012	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
537021001013	homodimer interface [polypeptide binding]; other site
537021001014	motif 1; other site
537021001015	active site
537021001016	motif 2; other site
537021001017	GAD domain; Region: GAD; pfam02938
537021001018	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
537021001019	active site
537021001020	motif 3; other site
537021001021	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
537021001022	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
537021001023	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
537021001024	catalytic site [active]
537021001025	subunit interface [polypeptide binding]; other site
537021001026	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
537021001027	GTP-binding protein Der; Reviewed; Region: PRK00093
537021001028	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
537021001029	G1 box; other site
537021001030	GTP/Mg2+ binding site [chemical binding]; other site
537021001031	Switch I region; other site
537021001032	G2 box; other site
537021001033	Switch II region; other site
537021001034	G3 box; other site
537021001035	G4 box; other site
537021001036	G5 box; other site
537021001037	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
537021001038	G1 box; other site
537021001039	GTP/Mg2+ binding site [chemical binding]; other site
537021001040	Switch I region; other site
537021001041	G2 box; other site
537021001042	G3 box; other site
537021001043	Switch II region; other site
537021001044	G4 box; other site
537021001045	G5 box; other site
537021001046	S-adenosylmethionine synthetase; Validated; Region: PRK05250
537021001047	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
537021001048	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
537021001049	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
537021001050	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
537021001051	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
537021001052	non-specific DNA binding site [nucleotide binding]; other site
537021001053	salt bridge; other site
537021001054	sequence-specific DNA binding site [nucleotide binding]; other site
537021001055	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
537021001056	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
537021001057	putative active site [active]
537021001058	putative dimer interface [polypeptide binding]; other site
537021001059	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
537021001060	Transporter associated domain; Region: CorC_HlyC; smart01091
537021001061	metal-binding heat shock protein; Provisional; Region: PRK00016
537021001062	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
537021001063	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
537021001064	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
537021001065	FeS/SAM binding site; other site
537021001066	TRAM domain; Region: TRAM; pfam01938
537021001067	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
537021001068	Glycoprotease family; Region: Peptidase_M22; pfam00814
537021001069	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
537021001070	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
537021001071	GcrA cell cycle regulator; Region: GcrA; cl11564
537021001072	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
537021001073	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
537021001074	inhibitor-cofactor binding pocket; inhibition site
537021001075	pyridoxal 5'-phosphate binding site [chemical binding]; other site
537021001076	catalytic residue [active]
537021001077	ornithine carbamoyltransferase; Provisional; Region: PRK00779
537021001078	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
537021001079	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
537021001080	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
537021001081	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
537021001082	quinone interaction residues [chemical binding]; other site
537021001083	active site
537021001084	catalytic residues [active]
537021001085	FMN binding site [chemical binding]; other site
537021001086	substrate binding site [chemical binding]; other site
537021001087	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
537021001088	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
537021001089	TPR repeat; Region: TPR_11; pfam13414
537021001090	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
537021001091	TPR motif; other site
537021001092	binding surface
537021001093	TPR repeat; Region: TPR_11; pfam13414
537021001094	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
537021001095	binding surface
537021001096	TPR repeat; Region: TPR_11; pfam13414
537021001097	TPR motif; other site
537021001098	Tetratricopeptide repeat; Region: TPR_12; pfam13424
537021001099	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
537021001100	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
537021001101	active site
537021001102	hydrophilic channel; other site
537021001103	dimerization interface [polypeptide binding]; other site
537021001104	catalytic residues [active]
537021001105	active site lid [active]
537021001106	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
537021001107	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
537021001108	ATP-grasp domain; Region: ATP-grasp_4; cl17255
537021001109	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
537021001110	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
537021001111	ATP-grasp domain; Region: ATP-grasp_4; cl17255
537021001112	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
537021001113	IMP binding site; other site
537021001114	dimer interface [polypeptide binding]; other site
537021001115	interdomain contacts; other site
537021001116	partial ornithine binding site; other site
537021001117	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
537021001118	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
537021001119	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
537021001120	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
537021001121	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
537021001122	pyruvate kinase; Provisional; Region: PRK06247
537021001123	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
537021001124	domain interfaces; other site
537021001125	active site
537021001126	Protein of unknown function (DUF1036); Region: DUF1036; pfam06282
537021001127	Predicted transcriptional regulator [Transcription]; Region: COG2932
537021001128	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
537021001129	Catalytic site [active]
537021001130	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
537021001131	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
537021001132	active site
537021001133	HIGH motif; other site
537021001134	nucleotide binding site [chemical binding]; other site
537021001135	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
537021001136	active site
537021001137	KMSKS motif; other site
537021001138	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
537021001139	tRNA binding surface [nucleotide binding]; other site
537021001140	anticodon binding site; other site
537021001141	PAS fold; Region: PAS_4; pfam08448
537021001142	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
537021001143	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
537021001144	dimer interface [polypeptide binding]; other site
537021001145	phosphorylation site [posttranslational modification]
537021001146	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
537021001147	ATP binding site [chemical binding]; other site
537021001148	Mg2+ binding site [ion binding]; other site
537021001149	G-X-G motif; other site
537021001150	Response regulator receiver domain; Region: Response_reg; pfam00072
537021001151	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
537021001152	active site
537021001153	phosphorylation site [posttranslational modification]
537021001154	intermolecular recognition site; other site
537021001155	dimerization interface [polypeptide binding]; other site
537021001156	aconitate hydratase; Validated; Region: PRK09277
537021001157	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
537021001158	substrate binding site [chemical binding]; other site
537021001159	ligand binding site [chemical binding]; other site
537021001160	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
537021001161	substrate binding site [chemical binding]; other site
537021001162	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
537021001163	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
537021001164	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
537021001165	active site
537021001166	dimer interface [polypeptide binding]; other site
537021001167	DNA polymerase III subunit beta; Validated; Region: PRK05643
537021001168	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
537021001169	putative DNA binding surface [nucleotide binding]; other site
537021001170	dimer interface [polypeptide binding]; other site
537021001171	beta-clamp/clamp loader binding surface; other site
537021001172	beta-clamp/translesion DNA polymerase binding surface; other site
537021001173	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
537021001174	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
537021001175	active site
537021001176	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
537021001177	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
537021001178	RNA binding site [nucleotide binding]; other site
537021001179	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
537021001180	RNA binding site [nucleotide binding]; other site
537021001181	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
537021001182	RNA binding site [nucleotide binding]; other site
537021001183	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
537021001184	RNA binding site [nucleotide binding]; other site
537021001185	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
537021001186	RNA binding site [nucleotide binding]; other site
537021001187	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
537021001188	RNA binding site [nucleotide binding]; other site
537021001189	Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283
537021001190	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
537021001191	CMP-binding site; other site
537021001192	The sites determining sugar specificity; other site
537021001193	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
537021001194	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
537021001195	putative active site [active]
537021001196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530
537021001197	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
537021001198	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
537021001199	active site 1 [active]
537021001200	dimer interface [polypeptide binding]; other site
537021001201	active site 2 [active]
537021001202	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
537021001203	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
537021001204	dimer interface [polypeptide binding]; other site
537021001205	active site
537021001206	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
537021001207	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
537021001208	NAD binding site [chemical binding]; other site
537021001209	homotetramer interface [polypeptide binding]; other site
537021001210	homodimer interface [polypeptide binding]; other site
537021001211	substrate binding site [chemical binding]; other site
537021001212	active site
537021001213	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
537021001214	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
537021001215	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
537021001216	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
537021001217	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
537021001218	pyridoxal 5'-phosphate binding site [chemical binding]; other site
537021001219	catalytic residue [active]
537021001220	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
537021001221	DNA methylase; Region: N6_N4_Mtase; pfam01555
537021001222	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
537021001223	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
537021001224	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
537021001225	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
537021001226	putative active site [active]
537021001227	PAS fold; Region: PAS_3; pfam08447
537021001228	heme pocket [chemical binding]; other site
537021001229	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
537021001230	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
537021001231	metal binding site [ion binding]; metal-binding site
537021001232	active site
537021001233	I-site; other site
537021001234	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
537021001235	Domain of unknown function (DUF329); Region: DUF329; cl01144
537021001236	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
537021001237	rRNA binding site [nucleotide binding]; other site
537021001238	predicted 30S ribosome binding site; other site
537021001239	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
537021001240	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
537021001241	Subunit I/III interface [polypeptide binding]; other site
537021001242	Subunit III/IV interface [polypeptide binding]; other site
537021001243	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
537021001244	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
537021001245	D-pathway; other site
537021001246	Putative ubiquinol binding site [chemical binding]; other site
537021001247	Low-spin heme (heme b) binding site [chemical binding]; other site
537021001248	Putative water exit pathway; other site
537021001249	Binuclear center (heme o3/CuB) [ion binding]; other site
537021001250	K-pathway; other site
537021001251	Putative proton exit pathway; other site
537021001252	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
537021001253	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
537021001254	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
537021001255	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
537021001256	Response regulator receiver domain; Region: Response_reg; pfam00072
537021001257	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
537021001258	active site
537021001259	phosphorylation site [posttranslational modification]
537021001260	intermolecular recognition site; other site
537021001261	dimerization interface [polypeptide binding]; other site
537021001262	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
537021001263	Thioredoxin; Region: Thioredoxin_4; pfam13462
537021001264	Protein of unknown function (DUF721); Region: DUF721; cl02324
537021001265	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
537021001266	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
537021001267	minor groove reading motif; other site
537021001268	helix-hairpin-helix signature motif; other site
537021001269	substrate binding pocket [chemical binding]; other site
537021001270	active site
537021001271	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
537021001272	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
537021001273	DNA binding and oxoG recognition site [nucleotide binding]
537021001274	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
537021001275	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
537021001276	trimer interface [polypeptide binding]; other site
537021001277	active site
537021001278	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
537021001279	trimer interface [polypeptide binding]; other site
537021001280	active site
537021001281	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
537021001282	ribonuclease P; Reviewed; Region: rnpA; PRK01313
537021001283	membrane protein insertase; Provisional; Region: PRK01318
537021001284	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
537021001285	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
537021001286	G1 box; other site
537021001287	GTP/Mg2+ binding site [chemical binding]; other site
537021001288	Switch I region; other site
537021001289	G2 box; other site
537021001290	G3 box; other site
537021001291	Switch II region; other site
537021001292	G4 box; other site
537021001293	G5 box; other site
537021001294	biotin synthase; Region: bioB; TIGR00433
537021001295	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
537021001296	FeS/SAM binding site; other site
537021001297	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
537021001298	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
537021001299	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
537021001300	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
537021001301	catalytic residue [active]
537021001302	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
537021001303	AAA domain; Region: AAA_26; pfam13500
537021001304	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
537021001305	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
537021001306	inhibitor-cofactor binding pocket; inhibition site
537021001307	pyridoxal 5'-phosphate binding site [chemical binding]; other site
537021001308	catalytic residue [active]
537021001309	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963
537021001310	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
537021001311	dimer interface [polypeptide binding]; other site
537021001312	active site
537021001313	CoA binding pocket [chemical binding]; other site
537021001314	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
537021001315	DNA binding site [nucleotide binding]
537021001316	active site
537021001317	Int/Topo IB signature motif; other site
537021001318	Domain of unknown function DUF59; Region: DUF59; pfam01883
537021001319	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
537021001320	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
537021001321	Walker A motif; other site
537021001322	ATP binding site [chemical binding]; other site
537021001323	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
537021001324	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
537021001325	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
537021001326	active site
537021001327	HslU subunit interaction site [polypeptide binding]; other site
537021001328	pantothenate kinase; Provisional; Region: PRK05439
537021001329	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
537021001330	ATP-binding site [chemical binding]; other site
537021001331	CoA-binding site [chemical binding]; other site
537021001332	Mg2+-binding site [ion binding]; other site
537021001333	phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344
537021001334	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
537021001335	active site
537021001336	metal-binding site [ion binding]
537021001337	nucleotide-binding site [chemical binding]; other site
537021001338	PAS fold; Region: PAS_7; pfam12860
537021001339	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
537021001340	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
537021001341	dimer interface [polypeptide binding]; other site
537021001342	phosphorylation site [posttranslational modification]
537021001343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
537021001344	ATP binding site [chemical binding]; other site
537021001345	Mg2+ binding site [ion binding]; other site
537021001346	G-X-G motif; other site
537021001347	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
537021001348	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
537021001349	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
537021001350	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
537021001351	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
537021001352	catalytic residues [active]
537021001353	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
537021001354	M42 glutamyl aminopeptidase; Region: Peptidase_M42; cl17262
537021001355	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
537021001356	dephospho-CoA kinase; Region: TIGR00152
537021001357	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
537021001358	CoA-binding site [chemical binding]; other site
537021001359	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
537021001360	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
537021001361	active site
537021001362	catalytic site [active]
537021001363	substrate binding site [chemical binding]; other site
537021001364	preprotein translocase subunit SecB; Validated; Region: PRK05751
537021001365	SecA binding site; other site
537021001366	Preprotein binding site; other site
537021001367	Tim44-like domain; Region: Tim44; pfam04280
537021001368	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
537021001369	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
537021001370	Mg2+ binding site [ion binding]; other site
537021001371	G-X-G motif; other site
537021001372	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
537021001373	anchoring element; other site
537021001374	dimer interface [polypeptide binding]; other site
537021001375	ATP binding site [chemical binding]; other site
537021001376	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
537021001377	active site
537021001378	putative metal-binding site [ion binding]; other site
537021001379	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
537021001380	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
537021001381	active site
537021001382	dimer interface [polypeptide binding]; other site
537021001383	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
537021001384	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
537021001385	substrate binding site [chemical binding]; other site
537021001386	active site
537021001387	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
537021001388	transcription termination factor Rho; Provisional; Region: rho; PRK09376
537021001389	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
537021001390	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
537021001391	RNA binding site [nucleotide binding]; other site
537021001392	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
537021001393	multimer interface [polypeptide binding]; other site
537021001394	Walker A motif; other site
537021001395	ATP binding site [chemical binding]; other site
537021001396	Walker B motif; other site
537021001397	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
537021001398	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
537021001399	trmE is a tRNA modification GTPase; Region: trmE; cd04164
537021001400	G1 box; other site
537021001401	GTP/Mg2+ binding site [chemical binding]; other site
537021001402	Switch I region; other site
537021001403	G2 box; other site
537021001404	Switch II region; other site
537021001405	G3 box; other site
537021001406	G4 box; other site
537021001407	G5 box; other site
537021001408	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
537021001409	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
537021001410	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
537021001411	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
537021001412	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
537021001413	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
537021001414	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
537021001415	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
537021001416	P-loop; other site
537021001417	Magnesium ion binding site [ion binding]; other site
537021001418	ParB-like nuclease domain; Region: ParBc; pfam02195
537021001419	KorB domain; Region: KorB; pfam08535
537021001420	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
537021001421	Lipopolysaccharide-assembly; Region: LptE; cl01125
537021001422	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
537021001423	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
537021001424	HIGH motif; other site
537021001425	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
537021001426	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
537021001427	active site
537021001428	KMSKS motif; other site
537021001429	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
537021001430	tRNA binding surface [nucleotide binding]; other site
537021001431	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
537021001432	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
537021001433	catalytic residue [active]
537021001434	Protein of unknown function (DUF1013); Region: DUF1013; cl11533
537021001435	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
537021001436	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
537021001437	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
537021001438	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
537021001439	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
537021001440	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
537021001441	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
537021001442	putative catalytic site [active]
537021001443	putative metal binding site [ion binding]; other site
537021001444	putative phosphate binding site [ion binding]; other site
537021001445	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
537021001446	RNA/DNA hybrid binding site [nucleotide binding]; other site
537021001447	active site
537021001448	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
537021001449	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
537021001450	putative active site [active]
537021001451	putative substrate binding site [chemical binding]; other site
537021001452	ATP binding site [chemical binding]; other site
537021001453	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
537021001454	active site
537021001455	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
537021001456	HIGH motif; other site
537021001457	dimer interface [polypeptide binding]; other site
537021001458	KMSKS motif; other site
537021001459	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
537021001460	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
537021001461	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
537021001462	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
537021001463	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
537021001464	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
537021001465	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
537021001466	generic binding surface II; other site
537021001467	generic binding surface I; other site
537021001468	ribosome maturation protein RimP; Reviewed; Region: PRK00092
537021001469	Sm and related proteins; Region: Sm_like; cl00259
537021001470	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
537021001471	putative oligomer interface [polypeptide binding]; other site
537021001472	putative RNA binding site [nucleotide binding]; other site
537021001473	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
537021001474	NusA N-terminal domain; Region: NusA_N; pfam08529
537021001475	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
537021001476	RNA binding site [nucleotide binding]; other site
537021001477	homodimer interface [polypeptide binding]; other site
537021001478	NusA-like KH domain; Region: KH_5; pfam13184
537021001479	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
537021001480	G-X-X-G motif; other site
537021001481	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
537021001482	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
537021001483	translation initiation factor IF-2; Region: IF-2; TIGR00487
537021001484	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
537021001485	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
537021001486	G1 box; other site
537021001487	putative GEF interaction site [polypeptide binding]; other site
537021001488	GTP/Mg2+ binding site [chemical binding]; other site
537021001489	Switch I region; other site
537021001490	G2 box; other site
537021001491	G3 box; other site
537021001492	Switch II region; other site
537021001493	G4 box; other site
537021001494	G5 box; other site
537021001495	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
537021001496	Translation-initiation factor 2; Region: IF-2; pfam11987
537021001497	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
537021001498	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
537021001499	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
537021001500	16S/18S rRNA binding site [nucleotide binding]; other site
537021001501	S13e-L30e interaction site [polypeptide binding]; other site
537021001502	25S rRNA binding site [nucleotide binding]; other site
537021001503	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
537021001504	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
537021001505	RNase E interface [polypeptide binding]; other site
537021001506	trimer interface [polypeptide binding]; other site
537021001507	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
537021001508	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
537021001509	RNase E interface [polypeptide binding]; other site
537021001510	trimer interface [polypeptide binding]; other site
537021001511	active site
537021001512	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
537021001513	putative nucleic acid binding region [nucleotide binding]; other site
537021001514	G-X-X-G motif; other site
537021001515	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
537021001516	RNA binding site [nucleotide binding]; other site
537021001517	domain interface; other site
537021001518	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
537021001519	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
537021001520	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
537021001521	metal binding site [ion binding]; metal-binding site
537021001522	dimer interface [polypeptide binding]; other site
537021001523	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
537021001524	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
537021001525	trimer interface [polypeptide binding]; other site
537021001526	active site
537021001527	substrate binding site [chemical binding]; other site
537021001528	CoA binding site [chemical binding]; other site
537021001529	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
537021001530	HIT family signature motif; other site
537021001531	catalytic residue [active]
537021001532	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
537021001533	rRNA interaction site [nucleotide binding]; other site
537021001534	S8 interaction site; other site
537021001535	putative laminin-1 binding site; other site
537021001536	elongation factor Ts; Provisional; Region: tsf; PRK09377
537021001537	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
537021001538	Elongation factor TS; Region: EF_TS; pfam00889
537021001539	Elongation factor TS; Region: EF_TS; pfam00889
537021001540	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
537021001541	putative nucleotide binding site [chemical binding]; other site
537021001542	uridine monophosphate binding site [chemical binding]; other site
537021001543	homohexameric interface [polypeptide binding]; other site
537021001544	ribosome recycling factor; Reviewed; Region: frr; PRK00083
537021001545	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
537021001546	hinge region; other site
537021001547	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834
537021001548	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
537021001549	catalytic residue [active]
537021001550	putative FPP diphosphate  binding site; other site
537021001551	putative FPP binding hydrophobic cleft; other site
537021001552	dimer interface [polypeptide binding]; other site
537021001553	putative IPP diphosphate binding site; other site
537021001554	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
537021001555	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
537021001556	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
537021001557	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
537021001558	active site
537021001559	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
537021001560	protein binding site [polypeptide binding]; other site
537021001561	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
537021001562	putative substrate binding region [chemical binding]; other site
537021001563	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
537021001564	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
537021001565	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
537021001566	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
537021001567	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
537021001568	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
537021001569	Surface antigen; Region: Bac_surface_Ag; pfam01103
537021001570	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
537021001571	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
537021001572	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
537021001573	trimer interface [polypeptide binding]; other site
537021001574	active site
537021001575	UDP-GlcNAc binding site [chemical binding]; other site
537021001576	lipid binding site [chemical binding]; lipid-binding site
537021001577	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
537021001578	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
537021001579	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
537021001580	active site
537021001581	Protein of unknown function (DUF1009); Region: DUF1009; cl09182
537021001582	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
537021001583	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
537021001584	recombination protein F; Reviewed; Region: recF; PRK00064
537021001585	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
537021001586	Walker A/P-loop; other site
537021001587	ATP binding site [chemical binding]; other site
537021001588	Q-loop/lid; other site
537021001589	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
537021001590	ABC transporter signature motif; other site
537021001591	Walker B; other site
537021001592	D-loop; other site
537021001593	H-loop/switch region; other site
537021001594	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
537021001595	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
537021001596	Ligand binding site; other site
537021001597	oligomer interface; other site
537021001598	Bacterial SH3 domain; Region: SH3_4; pfam06347
537021001599	Bacterial SH3 domain; Region: SH3_4; pfam06347
537021001600	hypothetical protein; Validated; Region: PRK00153
537021001601	recombination protein RecR; Reviewed; Region: recR; PRK00076
537021001602	RecR protein; Region: RecR; pfam02132
537021001603	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
537021001604	putative active site [active]
537021001605	putative metal-binding site [ion binding]; other site
537021001606	tetramer interface [polypeptide binding]; other site
537021001607	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
537021001608	FAD binding domain; Region: FAD_binding_4; pfam01565
537021001609	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
537021001610	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
537021001611	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
537021001612	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
537021001613	dimer interface [polypeptide binding]; other site
537021001614	motif 1; other site
537021001615	active site
537021001616	motif 2; other site
537021001617	motif 3; other site
537021001618	Methyltransferase domain; Region: Methyltransf_26; pfam13659
537021001619	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
537021001620	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
537021001621	substrate binding pocket [chemical binding]; other site
537021001622	chain length determination region; other site
537021001623	substrate-Mg2+ binding site; other site
537021001624	catalytic residues [active]
537021001625	aspartate-rich region 1; other site
537021001626	active site lid residues [active]
537021001627	aspartate-rich region 2; other site
537021001628	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
537021001629	ATP-NAD kinase; Region: NAD_kinase; pfam01513
537021001630	peptide chain release factor 2; Validated; Region: prfB; PRK00578
537021001631	This domain is found in peptide chain release factors; Region: PCRF; smart00937
537021001632	RF-1 domain; Region: RF-1; pfam00472
537021001633	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
537021001634	Transglycosylase; Region: Transgly; pfam00912
537021001635	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
537021001636	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
537021001637	homodimer interface [polypeptide binding]; other site
537021001638	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
537021001639	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
537021001640	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
537021001641	MutS domain I; Region: MutS_I; pfam01624
537021001642	MutS domain II; Region: MutS_II; pfam05188
537021001643	MutS domain III; Region: MutS_III; pfam05192
537021001644	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
537021001645	Walker A/P-loop; other site
537021001646	ATP binding site [chemical binding]; other site
537021001647	Q-loop/lid; other site
537021001648	ABC transporter signature motif; other site
537021001649	Walker B; other site
537021001650	D-loop; other site
537021001651	H-loop/switch region; other site
537021001652	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
537021001653	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
537021001654	IHF dimer interface [polypeptide binding]; other site
537021001655	IHF - DNA interface [nucleotide binding]; other site
537021001656	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
537021001657	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
537021001658	tandem repeat interface [polypeptide binding]; other site
537021001659	oligomer interface [polypeptide binding]; other site
537021001660	active site residues [active]
537021001661	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
537021001662	OstA-like protein; Region: OstA; pfam03968
537021001663	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
537021001664	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
537021001665	Walker A/P-loop; other site
537021001666	ATP binding site [chemical binding]; other site
537021001667	Q-loop/lid; other site
537021001668	ABC transporter signature motif; other site
537021001669	Walker B; other site
537021001670	D-loop; other site
537021001671	H-loop/switch region; other site
537021001672	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
537021001673	Fe-S cluster binding site [ion binding]; other site
537021001674	active site
537021001675	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
537021001676	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
537021001677	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
537021001678	dimer interface [polypeptide binding]; other site
537021001679	active site
537021001680	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
537021001681	catalytic residues [active]
537021001682	substrate binding site [chemical binding]; other site
537021001683	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
537021001684	Uncharacterized conserved protein [Function unknown]; Region: COG2835
537021001685	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
537021001686	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
537021001687	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
537021001688	Flp/Fap pilin component; Region: Flp_Fap; cl01585
537021001689	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
537021001690	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
537021001691	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
537021001692	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
537021001693	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
537021001694	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
537021001695	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
537021001696	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
537021001697	Type IV pili component [Cell motility and secretion]; Region: COG5461
537021001698	AAA domain; Region: AAA_31; pfam13614
537021001699	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
537021001700	septum site-determining protein MinD; Region: minD_bact; TIGR01968
537021001701	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
537021001702	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
537021001703	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
537021001704	ATP binding site [chemical binding]; other site
537021001705	Walker A motif; other site
537021001706	hexamer interface [polypeptide binding]; other site
537021001707	Walker B motif; other site
537021001708	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
537021001709	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
537021001710	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
537021001711	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
537021001712	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
537021001713	Ferritin-like domain; Region: Ferritin; pfam00210
537021001714	ferroxidase diiron center [ion binding]; other site
537021001715	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
537021001716	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
537021001717	ABC-ATPase subunit  interface; other site
537021001718	dimer interface [polypeptide binding]; other site
537021001719	putative PBP binding regions; other site
537021001720	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
537021001721	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
537021001722	Walker A/P-loop; other site
537021001723	ATP binding site [chemical binding]; other site
537021001724	Q-loop/lid; other site
537021001725	ABC transporter signature motif; other site
537021001726	Walker B; other site
537021001727	D-loop; other site
537021001728	H-loop/switch region; other site
537021001729	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
537021001730	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
537021001731	metal binding site [ion binding]; metal-binding site
537021001732	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
537021001733	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
537021001734	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
537021001735	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
537021001736	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
537021001737	RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806
537021001738	RimM N-terminal domain; Region: RimM; pfam01782
537021001739	PRC-barrel domain; Region: PRC; pfam05239
537021001740	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
537021001741	signal recognition particle protein; Provisional; Region: PRK10867
537021001742	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
537021001743	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
537021001744	P loop; other site
537021001745	GTP binding site [chemical binding]; other site
537021001746	Signal peptide binding domain; Region: SRP_SPB; pfam02978
537021001747	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
537021001748	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
537021001749	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
537021001750	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
537021001751	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
537021001752	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
537021001753	Intracellular septation protein A; Region: IspA; cl01098
537021001754	PBP superfamily domain; Region: PBP_like_2; pfam12849
537021001755	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
537021001756	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
537021001757	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
537021001758	dimer interface [polypeptide binding]; other site
537021001759	conserved gate region; other site
537021001760	putative PBP binding loops; other site
537021001761	ABC-ATPase subunit interface; other site
537021001762	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
537021001763	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
537021001764	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
537021001765	dimer interface [polypeptide binding]; other site
537021001766	conserved gate region; other site
537021001767	putative PBP binding loops; other site
537021001768	ABC-ATPase subunit interface; other site
537021001769	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
537021001770	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
537021001771	Walker A/P-loop; other site
537021001772	ATP binding site [chemical binding]; other site
537021001773	Q-loop/lid; other site
537021001774	ABC transporter signature motif; other site
537021001775	Walker B; other site
537021001776	D-loop; other site
537021001777	H-loop/switch region; other site
537021001778	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
537021001779	PhoU domain; Region: PhoU; pfam01895
537021001780	PhoU domain; Region: PhoU; pfam01895
537021001781	heat shock protein GrpE; Provisional; Region: PRK14141
537021001782	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
537021001783	dimer interface [polypeptide binding]; other site
537021001784	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
537021001785	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
537021001786	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
537021001787	dimer interface [polypeptide binding]; other site
537021001788	phosphorylation site [posttranslational modification]
537021001789	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
537021001790	ATP binding site [chemical binding]; other site
537021001791	Mg2+ binding site [ion binding]; other site
537021001792	G-X-G motif; other site
537021001793	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
537021001794	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
537021001795	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
537021001796	protein binding site [polypeptide binding]; other site
537021001797	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
537021001798	protein binding site [polypeptide binding]; other site
537021001799	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
537021001800	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
537021001801	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
537021001802	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
537021001803	glutathione synthetase; Provisional; Region: PRK05246
537021001804	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
537021001805	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
537021001806	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
537021001807	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
537021001808	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
537021001809	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
537021001810	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
537021001811	DNA binding residues [nucleotide binding]
537021001812	dimerization interface [polypeptide binding]; other site
537021001813	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
537021001814	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
537021001815	DNA binding residues [nucleotide binding]
537021001816	dimerization interface [polypeptide binding]; other site
537021001817	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
537021001818	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
537021001819	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
537021001820	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
537021001821	FliG C-terminal domain; Region: FliG_C; pfam01706
537021001822	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
537021001823	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
537021001824	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
537021001825	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
537021001826	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
537021001827	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
537021001828	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
537021001829	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
537021001830	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
537021001831	Walker A motif; other site
537021001832	ATP binding site [chemical binding]; other site
537021001833	Walker B motif; other site
537021001834	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
537021001835	Peptidase family M23; Region: Peptidase_M23; pfam01551
537021001836	Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496
537021001837	seryl-tRNA synthetase; Provisional; Region: PRK05431
537021001838	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
537021001839	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
537021001840	dimer interface [polypeptide binding]; other site
537021001841	active site
537021001842	motif 1; other site
537021001843	motif 2; other site
537021001844	motif 3; other site
537021001845	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
537021001846	putative coenzyme Q binding site [chemical binding]; other site
537021001847	lipoyl synthase; Provisional; Region: PRK05481
537021001848	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
537021001849	FeS/SAM binding site; other site
537021001850	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
537021001851	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
537021001852	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
537021001853	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
537021001854	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
537021001855	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
537021001856	E3 interaction surface; other site
537021001857	lipoyl attachment site [posttranslational modification]; other site
537021001858	e3 binding domain; Region: E3_binding; pfam02817
537021001859	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
537021001860	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
537021001861	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
537021001862	E3 interaction surface; other site
537021001863	lipoyl attachment site [posttranslational modification]; other site
537021001864	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
537021001865	alpha subunit interface [polypeptide binding]; other site
537021001866	TPP binding site [chemical binding]; other site
537021001867	heterodimer interface [polypeptide binding]; other site
537021001868	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
537021001869	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
537021001870	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
537021001871	tetramer interface [polypeptide binding]; other site
537021001872	TPP-binding site [chemical binding]; other site
537021001873	heterodimer interface [polypeptide binding]; other site
537021001874	phosphorylation loop region [posttranslational modification]
537021001875	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
537021001876	Septum formation initiator; Region: DivIC; pfam04977
537021001877	enolase; Provisional; Region: eno; PRK00077
537021001878	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
537021001879	dimer interface [polypeptide binding]; other site
537021001880	metal binding site [ion binding]; metal-binding site
537021001881	substrate binding pocket [chemical binding]; other site
537021001882	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
537021001883	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
537021001884	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
537021001885	putative RNA binding site [nucleotide binding]; other site
537021001886	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
537021001887	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
537021001888	S-adenosylmethionine binding site [chemical binding]; other site
537021001889	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
537021001890	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
537021001891	purine monophosphate binding site [chemical binding]; other site
537021001892	dimer interface [polypeptide binding]; other site
537021001893	putative catalytic residues [active]
537021001894	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
537021001895	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
537021001896	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
537021001897	active site clefts [active]
537021001898	zinc binding site [ion binding]; other site
537021001899	dimer interface [polypeptide binding]; other site
537021001900	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
537021001901	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
537021001902	exonuclease I; Provisional; Region: sbcB; PRK11779
537021001903	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
537021001904	active site
537021001905	catalytic site [active]
537021001906	substrate binding site [chemical binding]; other site
537021001907	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
537021001908	hypothetical protein; Validated; Region: PRK00110
537021001909	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
537021001910	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
537021001911	putative active site [active]
537021001912	metal binding site [ion binding]; metal-binding site
537021001913	homodimer binding site [polypeptide binding]; other site
537021001914	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
537021001915	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
537021001916	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
537021001917	TPP-binding site [chemical binding]; other site
537021001918	dimer interface [polypeptide binding]; other site
537021001919	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
537021001920	PYR/PP interface [polypeptide binding]; other site
537021001921	dimer interface [polypeptide binding]; other site
537021001922	TPP binding site [chemical binding]; other site
537021001923	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
537021001924	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
537021001925	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
537021001926	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
537021001927	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
537021001928	Phosphoglycerate kinase; Region: PGK; pfam00162
537021001929	substrate binding site [chemical binding]; other site
537021001930	hinge regions; other site
537021001931	ADP binding site [chemical binding]; other site
537021001932	catalytic site [active]
537021001933	Class I aldolases; Region: Aldolase_Class_I; cl17187
537021001934	catalytic residue [active]
537021001935	Protein of unknown function (DUF1465); Region: DUF1465; cl11562
537021001936	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
537021001937	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
537021001938	active site
537021001939	(T/H)XGH motif; other site
537021001940	GTPase CgtA; Reviewed; Region: obgE; PRK12299
537021001941	GTP1/OBG; Region: GTP1_OBG; pfam01018
537021001942	Obg GTPase; Region: Obg; cd01898
537021001943	G1 box; other site
537021001944	GTP/Mg2+ binding site [chemical binding]; other site
537021001945	Switch I region; other site
537021001946	G2 box; other site
537021001947	G3 box; other site
537021001948	Switch II region; other site
537021001949	G4 box; other site
537021001950	G5 box; other site
537021001951	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
537021001952	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
537021001953	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
537021001954	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
537021001955	AAA domain; Region: AAA_23; pfam13476
537021001956	Walker A/P-loop; other site
537021001957	ATP binding site [chemical binding]; other site
537021001958	chaperone protein DnaJ; Provisional; Region: PRK10767
537021001959	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
537021001960	HSP70 interaction site [polypeptide binding]; other site
537021001961	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
537021001962	substrate binding site [polypeptide binding]; other site
537021001963	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
537021001964	Zn binding sites [ion binding]; other site
537021001965	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
537021001966	dimer interface [polypeptide binding]; other site
537021001967	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
537021001968	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
537021001969	nucleotide binding site [chemical binding]; other site
537021001970	NEF interaction site [polypeptide binding]; other site
537021001971	SBD interface [polypeptide binding]; other site
537021001972	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
537021001973	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
537021001974	catalytic site [active]
537021001975	putative active site [active]
537021001976	putative substrate binding site [chemical binding]; other site
537021001977	Imelysin; Region: Peptidase_M75; cl09159
537021001978	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
537021001979	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
537021001980	Creatinine amidohydrolase; Region: Creatininase; pfam02633
537021001981	ribonuclease PH; Reviewed; Region: rph; PRK00173
537021001982	Ribonuclease PH; Region: RNase_PH_bact; cd11362
537021001983	hexamer interface [polypeptide binding]; other site
537021001984	active site
537021001985	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
537021001986	active site
537021001987	dimerization interface [polypeptide binding]; other site
537021001988	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
537021001989	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
537021001990	FeS/SAM binding site; other site
537021001991	HemN C-terminal domain; Region: HemN_C; pfam06969
537021001992	DnaA N-terminal domain; Region: DnaA_N; pfam11638
537021001993	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
537021001994	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
537021001995	Walker A motif; other site
537021001996	ATP binding site [chemical binding]; other site
537021001997	Walker B motif; other site
537021001998	arginine finger; other site
537021001999	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
537021002000	DnaA box-binding interface [nucleotide binding]; other site
537021002001	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
537021002002	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
537021002003	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
537021002004	DNA binding site [nucleotide binding]
537021002005	catalytic residue [active]
537021002006	H2TH interface [polypeptide binding]; other site
537021002007	putative catalytic residues [active]
537021002008	turnover-facilitating residue; other site
537021002009	intercalation triad [nucleotide binding]; other site
537021002010	8OG recognition residue [nucleotide binding]; other site
537021002011	putative reading head residues; other site
537021002012	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
537021002013	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
537021002014	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
537021002015	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
537021002016	S-adenosylmethionine binding site [chemical binding]; other site
537021002017	ABC1 family; Region: ABC1; cl17513
537021002018	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
537021002019	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
537021002020	Flavoprotein; Region: Flavoprotein; pfam02441
537021002021	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
537021002022	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
537021002023	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
537021002024	putative dimer interface [polypeptide binding]; other site
537021002025	iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920
537021002026	Rrf2 family protein; Region: rrf2_super; TIGR00738
537021002027	primosome assembly protein PriA; Validated; Region: PRK05580
537021002028	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
537021002029	ATP binding site [chemical binding]; other site
537021002030	putative Mg++ binding site [ion binding]; other site
537021002031	helicase superfamily c-terminal domain; Region: HELICc; smart00490
537021002032	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
537021002033	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
537021002034	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
537021002035	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
537021002036	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
537021002037	beta subunit interaction interface [polypeptide binding]; other site
537021002038	Walker A motif; other site
537021002039	ATP binding site [chemical binding]; other site
537021002040	Walker B motif; other site
537021002041	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
537021002042	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
537021002043	core domain interface [polypeptide binding]; other site
537021002044	delta subunit interface [polypeptide binding]; other site
537021002045	epsilon subunit interface [polypeptide binding]; other site
537021002046	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
537021002047	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
537021002048	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
537021002049	alpha subunit interaction interface [polypeptide binding]; other site
537021002050	Walker A motif; other site
537021002051	ATP binding site [chemical binding]; other site
537021002052	Walker B motif; other site
537021002053	inhibitor binding site; inhibition site
537021002054	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
537021002055	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14736
537021002056	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
537021002057	gamma subunit interface [polypeptide binding]; other site
537021002058	epsilon subunit interface [polypeptide binding]; other site
537021002059	LBP interface [polypeptide binding]; other site
537021002060	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
537021002061	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
537021002062	GDP-binding site [chemical binding]; other site
537021002063	ACT binding site; other site
537021002064	IMP binding site; other site
537021002065	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
537021002066	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
537021002067	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
537021002068	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
537021002069	DNA binding residues [nucleotide binding]
537021002070	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
537021002071	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
537021002072	RNA binding surface [nucleotide binding]; other site
537021002073	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
537021002074	active site
537021002075	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
537021002076	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
537021002077	active site
537021002078	metal binding site [ion binding]; metal-binding site
537021002079	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
537021002080	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
537021002081	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
537021002082	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
537021002083	active site
537021002084	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
537021002085	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
537021002086	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
537021002087	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
537021002088	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
537021002089	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
537021002090	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
537021002091	active site
537021002092	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
537021002093	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
537021002094	substrate-cofactor binding pocket; other site
537021002095	pyridoxal 5'-phosphate binding site [chemical binding]; other site
537021002096	catalytic residue [active]
537021002097	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
537021002098	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
537021002099	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
537021002100	aspartate aminotransferase; Provisional; Region: PRK05764
537021002101	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
537021002102	pyridoxal 5'-phosphate binding site [chemical binding]; other site
537021002103	homodimer interface [polypeptide binding]; other site
537021002104	catalytic residue [active]
537021002105	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
537021002106	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
537021002107	ATP binding site [chemical binding]; other site
537021002108	putative Mg++ binding site [ion binding]; other site
537021002109	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
537021002110	nucleotide binding region [chemical binding]; other site
537021002111	ATP-binding site [chemical binding]; other site
537021002112	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
537021002113	RNA binding site [nucleotide binding]; other site
537021002114	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
537021002115	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
537021002116	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
537021002117	GIY-YIG motif/motif A; other site
537021002118	active site
537021002119	catalytic site [active]
537021002120	putative DNA binding site [nucleotide binding]; other site
537021002121	metal binding site [ion binding]; metal-binding site
537021002122	UvrB/uvrC motif; Region: UVR; pfam02151
537021002123	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
537021002124	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
537021002125	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
537021002126	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
537021002127	dimer interface [polypeptide binding]; other site
537021002128	conserved gate region; other site
537021002129	putative PBP binding loops; other site
537021002130	ABC-ATPase subunit interface; other site
537021002131	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
537021002132	dimer interface [polypeptide binding]; other site
537021002133	conserved gate region; other site
537021002134	putative PBP binding loops; other site
537021002135	ABC-ATPase subunit interface; other site
537021002136	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
537021002137	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
537021002138	Walker A/P-loop; other site
537021002139	ATP binding site [chemical binding]; other site
537021002140	Q-loop/lid; other site
537021002141	ABC transporter signature motif; other site
537021002142	Walker B; other site
537021002143	D-loop; other site
537021002144	H-loop/switch region; other site
537021002145	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
537021002146	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
537021002147	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
537021002148	NAD(P) binding site [chemical binding]; other site
537021002149	active site
537021002150	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
537021002151	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
537021002152	C-terminal domain interface [polypeptide binding]; other site
537021002153	GSH binding site (G-site) [chemical binding]; other site
537021002154	dimer interface [polypeptide binding]; other site
537021002155	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
537021002156	N-terminal domain interface [polypeptide binding]; other site
537021002157	dimer interface [polypeptide binding]; other site
537021002158	substrate binding pocket (H-site) [chemical binding]; other site
537021002159	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
537021002160	Tetratricopeptide repeat; Region: TPR_16; pfam13432
537021002161	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
537021002162	binding surface
537021002163	TPR motif; other site
537021002164	Tetratricopeptide repeat; Region: TPR_16; pfam13432
537021002165	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
537021002166	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
537021002167	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
537021002168	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
537021002169	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
537021002170	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
537021002171	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
537021002172	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
537021002173	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
537021002174	active site
537021002175	DNA binding site [nucleotide binding]
537021002176	Int/Topo IB signature motif; other site
537021002177	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
537021002178	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
537021002179	HSP70 interaction site [polypeptide binding]; other site
537021002180	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
537021002181	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
537021002182	Methyltransferase domain; Region: Methyltransf_23; pfam13489
537021002183	Methyltransferase domain; Region: Methyltransf_11; pfam08241
537021002184	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
537021002185	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
537021002186	putative acyl-acceptor binding pocket; other site
537021002187	Uncharacterized conserved protein [Function unknown]; Region: COG1434
537021002188	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
537021002189	putative active site [active]
537021002190	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
537021002191	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
537021002192	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
537021002193	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
537021002194	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
537021002195	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
537021002196	Walker A/P-loop; other site
537021002197	ATP binding site [chemical binding]; other site
537021002198	Q-loop/lid; other site
537021002199	ABC transporter signature motif; other site
537021002200	Walker B; other site
537021002201	D-loop; other site
537021002202	H-loop/switch region; other site
537021002203	Predicted permeases [General function prediction only]; Region: RarD; COG2962
537021002204	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
537021002205	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
537021002206	active site
537021002207	HIGH motif; other site
537021002208	nucleotide binding site [chemical binding]; other site
537021002209	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
537021002210	KMSKS motif; other site
537021002211	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
537021002212	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
537021002213	TadE-like protein; Region: TadE; pfam07811
537021002214	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
537021002215	TadE-like protein; Region: TadE; pfam07811
537021002216	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
537021002217	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
537021002218	active site
537021002219	substrate binding site [chemical binding]; other site
537021002220	cosubstrate binding site; other site
537021002221	catalytic site [active]
537021002222	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
537021002223	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
537021002224	dimerization interface [polypeptide binding]; other site
537021002225	putative ATP binding site [chemical binding]; other site
537021002226	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
537021002227	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
537021002228	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
537021002229	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
537021002230	Oligomerisation domain; Region: Oligomerisation; cl00519
537021002231	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
537021002232	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
537021002233	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
537021002234	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
537021002235	dimer interface [polypeptide binding]; other site
537021002236	conserved gate region; other site
537021002237	putative PBP binding loops; other site
537021002238	ABC-ATPase subunit interface; other site
537021002239	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
537021002240	dimer interface [polypeptide binding]; other site
537021002241	conserved gate region; other site
537021002242	putative PBP binding loops; other site
537021002243	ABC-ATPase subunit interface; other site
537021002244	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
537021002245	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
537021002246	Walker A/P-loop; other site
537021002247	ATP binding site [chemical binding]; other site
537021002248	Q-loop/lid; other site
537021002249	ABC transporter signature motif; other site
537021002250	Walker B; other site
537021002251	D-loop; other site
537021002252	H-loop/switch region; other site
537021002253	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
537021002254	NodB motif; other site
537021002255	putative active site [active]
537021002256	putative catalytic site [active]
537021002257	Zn binding site [ion binding]; other site
537021002258	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
537021002259	putative active site [active]
537021002260	Ap4A binding site [chemical binding]; other site
537021002261	nudix motif; other site
537021002262	putative metal binding site [ion binding]; other site
537021002263	BRO family, N-terminal domain; Region: Bro-N; pfam02498
537021002264	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
537021002265	active site
537021002266	putative DNA-binding cleft [nucleotide binding]; other site
537021002267	dimer interface [polypeptide binding]; other site
537021002268	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
537021002269	RuvA N terminal domain; Region: RuvA_N; pfam01330
537021002270	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
537021002271	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
537021002272	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
537021002273	Walker A motif; other site
537021002274	ATP binding site [chemical binding]; other site
537021002275	Walker B motif; other site
537021002276	arginine finger; other site
537021002277	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
537021002278	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
537021002279	translocation protein TolB; Provisional; Region: tolB; PRK05137
537021002280	TolB amino-terminal domain; Region: TolB_N; pfam04052
537021002281	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
537021002282	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
537021002283	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
537021002284	ligand binding site [chemical binding]; other site
537021002285	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
537021002286	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
537021002287	Ligand Binding Site [chemical binding]; other site
537021002288	FtsH Extracellular; Region: FtsH_ext; pfam06480
537021002289	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
537021002290	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
537021002291	Walker A motif; other site
537021002292	ATP binding site [chemical binding]; other site
537021002293	Walker B motif; other site
537021002294	arginine finger; other site
537021002295	Peptidase family M41; Region: Peptidase_M41; pfam01434
537021002296	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
537021002297	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
537021002298	active site
537021002299	substrate binding site [chemical binding]; other site
537021002300	metal binding site [ion binding]; metal-binding site
537021002301	NADH dehydrogenase; Validated; Region: PRK08183
537021002302	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765
537021002303	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
537021002304	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
537021002305	ABC-ATPase subunit  interface; other site
537021002306	dimer interface [polypeptide binding]; other site
537021002307	putative PBP binding regions; other site
537021002308	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
537021002309	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
537021002310	ABC-ATPase subunit  interface; other site
537021002311	dimer interface [polypeptide binding]; other site
537021002312	putative PBP binding regions; other site
537021002313	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
537021002314	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
537021002315	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
537021002316	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
537021002317	metal binding site [ion binding]; metal-binding site
537021002318	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
537021002319	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
537021002320	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
537021002321	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
537021002322	NAD(P) binding site [chemical binding]; other site
537021002323	homotetramer interface [polypeptide binding]; other site
537021002324	homodimer interface [polypeptide binding]; other site
537021002325	active site
537021002326	acyl carrier protein; Provisional; Region: acpP; PRK00982
537021002327	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
537021002328	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
537021002329	dimer interface [polypeptide binding]; other site
537021002330	active site
537021002331	YceG-like family; Region: YceG; pfam02618
537021002332	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
537021002333	dimerization interface [polypeptide binding]; other site
537021002334	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
537021002335	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
537021002336	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
537021002337	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
537021002338	ligand binding site [chemical binding]; other site
537021002339	chemotaxis protein; Reviewed; Region: PRK12798
537021002340	proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787
537021002341	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
537021002342	active site
537021002343	dimerization interface [polypeptide binding]; other site
537021002344	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
537021002345	DNA binding site [nucleotide binding]
537021002346	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
537021002347	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
537021002348	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
537021002349	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
537021002350	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
537021002351	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
537021002352	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
537021002353	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
537021002354	Flagellar protein FlaF; Region: FlaF; cl11454
537021002355	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
537021002356	Flagellar protein FlbT; Region: FlbT; cl11455
537021002357	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
537021002358	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
537021002359	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
537021002360	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
537021002361	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
537021002362	cofactor binding site; other site
537021002363	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
537021002364	FHIPEP family; Region: FHIPEP; pfam00771
537021002365	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
537021002366	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
537021002367	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
537021002368	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
537021002369	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
537021002370	homodimer interface [polypeptide binding]; other site
537021002371	NADP binding site [chemical binding]; other site
537021002372	substrate binding site [chemical binding]; other site
537021002373	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
537021002374	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
537021002375	putative active site [active]
537021002376	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
537021002377	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
537021002378	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
537021002379	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
537021002380	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
537021002381	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
537021002382	ATP cone domain; Region: ATP-cone; pfam03477
537021002383	Class I ribonucleotide reductase; Region: RNR_I; cd01679
537021002384	active site
537021002385	dimer interface [polypeptide binding]; other site
537021002386	catalytic residues [active]
537021002387	effector binding site; other site
537021002388	R2 peptide binding site; other site
537021002389	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
537021002390	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
537021002391	putative phosphate acyltransferase; Provisional; Region: PRK05331
537021002392	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
537021002393	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
537021002394	dimer interface [polypeptide binding]; other site
537021002395	active site
537021002396	CoA binding pocket [chemical binding]; other site
537021002397	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
537021002398	IHF dimer interface [polypeptide binding]; other site
537021002399	IHF - DNA interface [nucleotide binding]; other site
537021002400	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
537021002401	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
537021002402	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
537021002403	Cation efflux family; Region: Cation_efflux; cl00316
537021002404	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
537021002405	ATP binding site [chemical binding]; other site
537021002406	active site
537021002407	substrate binding site [chemical binding]; other site
537021002408	antiporter inner membrane protein; Provisional; Region: PRK11670
537021002409	Domain of unknown function DUF59; Region: DUF59; pfam01883
537021002410	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
537021002411	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
537021002412	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
537021002413	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
537021002414	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
537021002415	metal ion-dependent adhesion site (MIDAS); other site
537021002416	DNA primase; Validated; Region: dnaG; PRK05667
537021002417	CHC2 zinc finger; Region: zf-CHC2; cl17510
537021002418	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
537021002419	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
537021002420	active site
537021002421	metal binding site [ion binding]; metal-binding site
537021002422	interdomain interaction site; other site
537021002423	KpsF/GutQ family protein; Region: kpsF; TIGR00393
537021002424	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
537021002425	putative active site [active]
537021002426	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
537021002427	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
537021002428	HsdM N-terminal domain; Region: HsdM_N; pfam12161
537021002429	Methyltransferase domain; Region: Methyltransf_26; pfam13659
537021002430	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
537021002431	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
537021002432	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
537021002433	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
537021002434	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
537021002435	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
537021002436	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
537021002437	putative substrate translocation pore; other site
537021002438	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
537021002439	dimer interface [polypeptide binding]; other site
537021002440	putative radical transfer pathway; other site
537021002441	diiron center [ion binding]; other site
537021002442	tyrosyl radical; other site
537021002443	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
537021002444	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
537021002445	active site
537021002446	Riboflavin kinase; Region: Flavokinase; smart00904
537021002447	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
537021002448	Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460
537021002449	active site
537021002450	motif I; other site
537021002451	motif II; other site
537021002452	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
537021002453	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
537021002454	oligomerisation interface [polypeptide binding]; other site
537021002455	mobile loop; other site
537021002456	roof hairpin; other site
537021002457	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
537021002458	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
537021002459	ring oligomerisation interface [polypeptide binding]; other site
537021002460	ATP/Mg binding site [chemical binding]; other site
537021002461	stacking interactions; other site
537021002462	hinge regions; other site
537021002463	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
537021002464	NADH dehydrogenase subunit B; Validated; Region: PRK06411
537021002465	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
537021002466	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
537021002467	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
537021002468	NADH dehydrogenase subunit D; Validated; Region: PRK06075
537021002469	NADH dehydrogenase subunit E; Validated; Region: PRK07539
537021002470	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
537021002471	putative dimer interface [polypeptide binding]; other site
537021002472	[2Fe-2S] cluster binding site [ion binding]; other site
537021002473	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
537021002474	SLBB domain; Region: SLBB; pfam10531
537021002475	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
537021002476	NADH dehydrogenase subunit G; Validated; Region: PRK09130
537021002477	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
537021002478	catalytic loop [active]
537021002479	iron binding site [ion binding]; other site
537021002480	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
537021002481	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
537021002482	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
537021002483	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
537021002484	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
537021002485	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
537021002486	4Fe-4S binding domain; Region: Fer4; cl02805
537021002487	4Fe-4S binding domain; Region: Fer4; pfam00037
537021002488	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
537021002489	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
537021002490	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
537021002491	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
537021002492	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
537021002493	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
537021002494	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
537021002495	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
537021002496	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
537021002497	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
537021002498	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
537021002499	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
537021002500	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
537021002501	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
537021002502	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
537021002503	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
537021002504	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
537021002505	prolyl-tRNA synthetase; Provisional; Region: PRK12325
537021002506	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
537021002507	dimer interface [polypeptide binding]; other site
537021002508	motif 1; other site
537021002509	active site
537021002510	motif 2; other site
537021002511	motif 3; other site
537021002512	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
537021002513	anticodon binding site; other site
537021002514	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
537021002515	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
537021002516	Walker A/P-loop; other site
537021002517	ATP binding site [chemical binding]; other site
537021002518	Q-loop/lid; other site
537021002519	ABC transporter signature motif; other site
537021002520	Walker B; other site
537021002521	D-loop; other site
537021002522	H-loop/switch region; other site
537021002523	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
537021002524	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
537021002525	S-adenosylmethionine binding site [chemical binding]; other site
537021002526	aspartate kinase; Reviewed; Region: PRK06635
537021002527	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
537021002528	putative catalytic residues [active]
537021002529	putative nucleotide binding site [chemical binding]; other site
537021002530	putative aspartate binding site [chemical binding]; other site
537021002531	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
537021002532	putative allosteric regulatory site; other site
537021002533	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
537021002534	peptide chain release factor 1; Validated; Region: prfA; PRK00591
537021002535	This domain is found in peptide chain release factors; Region: PCRF; smart00937
537021002536	RF-1 domain; Region: RF-1; pfam00472
537021002537	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
537021002538	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
537021002539	S-adenosylmethionine binding site [chemical binding]; other site
537021002540	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
537021002541	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
537021002542	Clp amino terminal domain; Region: Clp_N; pfam02861
537021002543	Clp amino terminal domain; Region: Clp_N; pfam02861
537021002544	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
537021002545	Walker A motif; other site
537021002546	ATP binding site [chemical binding]; other site
537021002547	Walker B motif; other site
537021002548	arginine finger; other site
537021002549	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
537021002550	Walker A motif; other site
537021002551	ATP binding site [chemical binding]; other site
537021002552	Walker B motif; other site
537021002553	arginine finger; other site
537021002554	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
537021002555	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
537021002556	Peptidase family M23; Region: Peptidase_M23; pfam01551
537021002557	Domain of unknown function DUF59; Region: DUF59; pfam01883
537021002558	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
537021002559	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
537021002560	active site
537021002561	DNA binding site [nucleotide binding]
537021002562	Int/Topo IB signature motif; other site
537021002563	hypothetical protein; Validated; Region: PRK00041
537021002564	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
537021002565	GTP cyclohydrolase I; Provisional; Region: PLN03044
537021002566	active site
537021002567	PilZ domain; Region: PilZ; pfam07238
537021002568	PilZ domain; Region: PilZ; pfam07238
537021002569	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
537021002570	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
537021002571	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
537021002572	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
537021002573	active site
537021002574	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385
537021002575	Response regulator receiver domain; Region: Response_reg; pfam00072
537021002576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
537021002577	active site
537021002578	phosphorylation site [posttranslational modification]
537021002579	intermolecular recognition site; other site
537021002580	dimerization interface [polypeptide binding]; other site
537021002581	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
537021002582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
537021002583	active site
537021002584	phosphorylation site [posttranslational modification]
537021002585	intermolecular recognition site; other site
537021002586	dimerization interface [polypeptide binding]; other site
537021002587	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
537021002588	DNA binding site [nucleotide binding]
537021002589	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
537021002590	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
537021002591	TM-ABC transporter signature motif; other site
537021002592	trigger factor; Provisional; Region: tig; PRK01490
537021002593	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
537021002594	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
537021002595	Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162
537021002596	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
537021002597	active site
537021002598	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
537021002599	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
537021002600	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
537021002601	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
537021002602	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
537021002603	DHH family; Region: DHH; pfam01368
537021002604	DHHA1 domain; Region: DHHA1; pfam02272
537021002605	isocitrate dehydrogenase; Validated; Region: PRK08299
537021002606	PAS fold; Region: PAS_7; pfam12860
537021002607	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
537021002608	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
537021002609	dimer interface [polypeptide binding]; other site
537021002610	phosphorylation site [posttranslational modification]
537021002611	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
537021002612	ATP binding site [chemical binding]; other site
537021002613	Mg2+ binding site [ion binding]; other site
537021002614	G-X-G motif; other site
537021002615	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
537021002616	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
537021002617	glutamate racemase; Provisional; Region: PRK00865
537021002618	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
537021002619	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
537021002620	catalytic site [active]
537021002621	G-X2-G-X-G-K; other site
537021002622	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
537021002623	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
537021002624	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
537021002625	putative active site [active]
537021002626	putative substrate binding site [chemical binding]; other site
537021002627	putative cosubstrate binding site; other site
537021002628	catalytic site [active]
537021002629	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
537021002630	DNA-binding site [nucleotide binding]; DNA binding site
537021002631	RNA-binding motif; other site
537021002632	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
537021002633	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
537021002634	active site
537021002635	Zn binding site [ion binding]; other site
537021002636	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
537021002637	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
537021002638	Walker A motif; other site
537021002639	ATP binding site [chemical binding]; other site
537021002640	Walker B motif; other site
537021002641	arginine finger; other site
537021002642	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
537021002643	DNA-binding interface [nucleotide binding]; DNA binding site
537021002644	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
537021002645	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
537021002646	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
537021002647	Walker A/P-loop; other site
537021002648	ATP binding site [chemical binding]; other site
537021002649	Q-loop/lid; other site
537021002650	ABC transporter signature motif; other site
537021002651	Walker B; other site
537021002652	D-loop; other site
537021002653	H-loop/switch region; other site
537021002654	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
537021002655	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
537021002656	Probable Catalytic site; other site
537021002657	metal-binding site
537021002658	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
537021002659	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
537021002660	Probable Catalytic site; other site
537021002661	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
537021002662	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
537021002663	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
537021002664	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
537021002665	NAD binding site [chemical binding]; other site
537021002666	substrate binding site [chemical binding]; other site
537021002667	homodimer interface [polypeptide binding]; other site
537021002668	active site
537021002669	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
537021002670	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
537021002671	NADP binding site [chemical binding]; other site
537021002672	active site
537021002673	putative substrate binding site [chemical binding]; other site
537021002674	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
537021002675	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
537021002676	substrate binding site; other site
537021002677	tetramer interface; other site
537021002678	Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754
537021002679	putative cation:proton antiport protein; Provisional; Region: PRK10669
537021002680	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
537021002681	TrkA-N domain; Region: TrkA_N; pfam02254
537021002682	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
537021002683	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
537021002684	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
537021002685	Protein export membrane protein; Region: SecD_SecF; pfam02355
537021002686	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
537021002687	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
537021002688	hinge; other site
537021002689	active site
537021002690	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
537021002691	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
537021002692	dimer interface [polypeptide binding]; other site
537021002693	motif 1; other site
537021002694	active site
537021002695	motif 2; other site
537021002696	motif 3; other site
537021002697	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
537021002698	anticodon binding site; other site
537021002699	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
537021002700	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827
537021002701	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
537021002702	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
537021002703	HIGH motif; other site
537021002704	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
537021002705	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
537021002706	active site
537021002707	KMSKS motif; other site
537021002708	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
537021002709	tRNA binding surface [nucleotide binding]; other site
537021002710	anticodon binding site; other site
537021002711	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
537021002712	TadE-like protein; Region: TadE; pfam07811
537021002713	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
537021002714	metal ion-dependent adhesion site (MIDAS); other site
537021002715	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
537021002716	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
537021002717	Uncharacterized conserved protein [Function unknown]; Region: COG1432
537021002718	LabA_like proteins; Region: LabA; cd10911
537021002719	putative metal binding site [ion binding]; other site
537021002720	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
537021002721	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
537021002722	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
537021002723	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
537021002724	Catalytic site [active]
537021002725	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
537021002726	ribonuclease III; Reviewed; Region: PRK12371
537021002727	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
537021002728	dimerization interface [polypeptide binding]; other site
537021002729	active site
537021002730	metal binding site [ion binding]; metal-binding site
537021002731	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
537021002732	dsRNA binding site [nucleotide binding]; other site
537021002733	GTPase Era; Reviewed; Region: era; PRK00089
537021002734	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
537021002735	G1 box; other site
537021002736	GTP/Mg2+ binding site [chemical binding]; other site
537021002737	Switch I region; other site
537021002738	G2 box; other site
537021002739	Switch II region; other site
537021002740	G3 box; other site
537021002741	G4 box; other site
537021002742	G5 box; other site
537021002743	KH domain; Region: KH_2; pfam07650
537021002744	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
537021002745	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
537021002746	Substrate binding site; other site
537021002747	Mg++ binding site; other site
537021002748	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
537021002749	active site
537021002750	substrate binding site [chemical binding]; other site
537021002751	CoA binding site [chemical binding]; other site
537021002752	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
537021002753	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
537021002754	glutaminase active site [active]
537021002755	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
537021002756	dimer interface [polypeptide binding]; other site
537021002757	active site
537021002758	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
537021002759	dimer interface [polypeptide binding]; other site
537021002760	active site
537021002761	Uncharacterized conserved protein [Function unknown]; Region: COG2928
537021002762	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
537021002763	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
537021002764	generic binding surface II; other site
537021002765	ssDNA binding site; other site
537021002766	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
537021002767	ATP binding site [chemical binding]; other site
537021002768	putative Mg++ binding site [ion binding]; other site
537021002769	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
537021002770	nucleotide binding region [chemical binding]; other site
537021002771	ATP-binding site [chemical binding]; other site
537021002772	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
537021002773	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
537021002774	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
537021002775	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
537021002776	ATP binding site [chemical binding]; other site
537021002777	putative Mg++ binding site [ion binding]; other site
537021002778	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
537021002779	nucleotide binding region [chemical binding]; other site
537021002780	ATP-binding site [chemical binding]; other site
537021002781	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
537021002782	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
537021002783	Recombination protein O N terminal; Region: RecO_N; pfam11967
537021002784	Recombination protein O C terminal; Region: RecO_C; pfam02565
537021002785	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
537021002786	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
537021002787	active site
537021002788	HIGH motif; other site
537021002789	dimer interface [polypeptide binding]; other site
537021002790	KMSKS motif; other site
537021002791	Uncharacterized conserved protein [Function unknown]; Region: COG1434
537021002792	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
537021002793	putative active site [active]
537021002794	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
537021002795	Part of AAA domain; Region: AAA_19; pfam13245
537021002796	Family description; Region: UvrD_C_2; pfam13538
537021002797	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
537021002798	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
537021002799	ligand binding site [chemical binding]; other site
537021002800	AsmA family; Region: AsmA; pfam05170
537021002801	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
537021002802	thymidylate synthase; Reviewed; Region: thyA; PRK01827
537021002803	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
537021002804	dimerization interface [polypeptide binding]; other site
537021002805	active site
537021002806	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
537021002807	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
537021002808	folate binding site [chemical binding]; other site
537021002809	NADP+ binding site [chemical binding]; other site
537021002810	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
537021002811	HflK protein; Region: hflK; TIGR01933
537021002812	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
537021002813	HflC protein; Region: hflC; TIGR01932
537021002814	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
537021002815	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
537021002816	motif II; other site
537021002817	Peptidase M15; Region: Peptidase_M15_3; cl01194
537021002818	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
537021002819	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
537021002820	dimer interface [polypeptide binding]; other site
537021002821	putative radical transfer pathway; other site
537021002822	diiron center [ion binding]; other site
537021002823	tyrosyl radical; other site
537021002824	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
537021002825	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
537021002826	putative substrate translocation pore; other site
537021002827	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
537021002828	putative GSH binding site [chemical binding]; other site
537021002829	catalytic residues [active]
537021002830	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
537021002831	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
537021002832	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
537021002833	dimerization interface [polypeptide binding]; other site
537021002834	ATP binding site [chemical binding]; other site
537021002835	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
537021002836	dimerization interface [polypeptide binding]; other site
537021002837	ATP binding site [chemical binding]; other site
537021002838	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
537021002839	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
537021002840	putative active site [active]
537021002841	catalytic triad [active]
537021002842	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
537021002843	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
537021002844	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
537021002845	ATP binding site [chemical binding]; other site
537021002846	active site
537021002847	substrate binding site [chemical binding]; other site
537021002848	adenylosuccinate lyase; Provisional; Region: PRK07492
537021002849	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
537021002850	tetramer interface [polypeptide binding]; other site
537021002851	active site
537021002852	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
537021002853	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
537021002854	substrate binding site [chemical binding]; other site
537021002855	hexamer interface [polypeptide binding]; other site
537021002856	metal binding site [ion binding]; metal-binding site
537021002857	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
537021002858	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
537021002859	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
537021002860	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
537021002861	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
537021002862	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
537021002863	GatB domain; Region: GatB_Yqey; smart00845
537021002864	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
537021002865	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
537021002866	Coenzyme A binding pocket [chemical binding]; other site
537021002867	excinuclease ABC subunit B; Provisional; Region: PRK05298
537021002868	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
537021002869	ATP binding site [chemical binding]; other site
537021002870	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
537021002871	nucleotide binding region [chemical binding]; other site
537021002872	ATP-binding site [chemical binding]; other site
537021002873	Ultra-violet resistance protein B; Region: UvrB; pfam12344
537021002874	UvrB/uvrC motif; Region: UVR; pfam02151
537021002875	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
537021002876	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
537021002877	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
537021002878	putative catalytic site [active]
537021002879	putative phosphate binding site [ion binding]; other site
537021002880	putative metal binding site [ion binding]; other site
537021002881	Fe-S metabolism associated domain; Region: SufE; cl00951
537021002882	NAD synthetase; Provisional; Region: PRK13981
537021002883	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
537021002884	multimer interface [polypeptide binding]; other site
537021002885	active site
537021002886	catalytic triad [active]
537021002887	protein interface 1 [polypeptide binding]; other site
537021002888	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
537021002889	homodimer interface [polypeptide binding]; other site
537021002890	NAD binding pocket [chemical binding]; other site
537021002891	ATP binding pocket [chemical binding]; other site
537021002892	Mg binding site [ion binding]; other site
537021002893	active-site loop [active]
537021002894	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
537021002895	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
537021002896	S-adenosylmethionine binding site [chemical binding]; other site
537021002897	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
537021002898	putative catalytic site [active]
537021002899	putative metal binding site [ion binding]; other site
537021002900	putative phosphate binding site [ion binding]; other site
537021002901	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
537021002902	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
537021002903	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
537021002904	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
537021002905	active site
537021002906	dimer interface [polypeptide binding]; other site
537021002907	motif 1; other site
537021002908	motif 2; other site
537021002909	motif 3; other site
537021002910	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
537021002911	anticodon binding site; other site
537021002912	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
537021002913	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
537021002914	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
537021002915	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
537021002916	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
537021002917	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
537021002918	active site
537021002919	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
537021002920	active site
537021002921	substrate binding pocket [chemical binding]; other site
537021002922	dimer interface [polypeptide binding]; other site
537021002923	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
537021002924	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
537021002925	diphosphomevalonate decarboxylase; Region: PLN02407
537021002926	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
537021002927	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
537021002928	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
537021002929	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
537021002930	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
537021002931	dimer interface [polypeptide binding]; other site
537021002932	active site
537021002933	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
537021002934	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
537021002935	homotetramer interface [polypeptide binding]; other site
537021002936	FMN binding site [chemical binding]; other site
537021002937	homodimer contacts [polypeptide binding]; other site
537021002938	putative active site [active]
537021002939	putative substrate binding site [chemical binding]; other site
537021002940	Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205
537021002941	homodimer interface [polypeptide binding]; other site
537021002942	substrate binding pocket [chemical binding]; other site
537021002943	catalytic residues [active]
537021002944	NADH/NADPH cofactor binding site [chemical binding]; other site
537021002945	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
537021002946	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
537021002947	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
537021002948	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
537021002949	trimer interface [polypeptide binding]; other site
537021002950	active site
537021002951	potential frameshift: common BLAST hit: gi|325291745|ref|YP_004277609.1| magnesium chelatase family protein
537021002952	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
537021002953	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
537021002954	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
537021002955	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
537021002956	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
537021002957	Ligand Binding Site [chemical binding]; other site
537021002958	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
537021002959	active site
537021002960	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
537021002961	HemY protein N-terminus; Region: HemY_N; pfam07219
537021002962	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
537021002963	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
537021002964	active site
537021002965	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
537021002966	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
537021002967	domain interfaces; other site
537021002968	active site
537021002969	UGMP family protein; Validated; Region: PRK09604
537021002970	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
537021002971	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
537021002972	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
537021002973	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
537021002974	EVE domain; Region: EVE; cl00728
537021002975	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
537021002976	Iron-sulfur protein interface; other site
537021002977	proximal quinone binding site [chemical binding]; other site
537021002978	SdhD (CybS) interface [polypeptide binding]; other site
537021002979	proximal heme binding site [chemical binding]; other site
537021002980	Succinate dehydrogenase, hydrophobic anchor subunit [Energy production and conversion]; Region: SdhD; COG2142
537021002981	Iron-sulfur protein interface; other site
537021002982	proximal heme binding site [chemical binding]; other site
537021002983	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
537021002984	L-aspartate oxidase; Provisional; Region: PRK06175
537021002985	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
537021002986	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
537021002987	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
537021002988	Protease inhibitor Inh; Region: Inh; pfam02974
537021002989	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
537021002990	Predicted ATPase [General function prediction only]; Region: COG1485
537021002991	malate dehydrogenase; Reviewed; Region: PRK06223
537021002992	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
537021002993	NAD(P) binding site [chemical binding]; other site
537021002994	dimer interface [polypeptide binding]; other site
537021002995	tetramer (dimer of dimers) interface [polypeptide binding]; other site
537021002996	substrate binding site [chemical binding]; other site
537021002997	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
537021002998	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
537021002999	CoA-ligase; Region: Ligase_CoA; pfam00549
537021003000	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
537021003001	CoA binding domain; Region: CoA_binding; smart00881
537021003002	CoA-ligase; Region: Ligase_CoA; pfam00549
537021003003	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
537021003004	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
537021003005	TPP-binding site [chemical binding]; other site
537021003006	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
537021003007	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
537021003008	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
537021003009	E3 interaction surface; other site
537021003010	lipoyl attachment site [posttranslational modification]; other site
537021003011	e3 binding domain; Region: E3_binding; pfam02817
537021003012	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
537021003013	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
537021003014	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
537021003015	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
537021003016	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
537021003017	tetramer (dimer of dimers) interface [polypeptide binding]; other site
537021003018	active site
537021003019	dimer interface [polypeptide binding]; other site
537021003020	glutathione reductase; Validated; Region: PRK06116
537021003021	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
537021003022	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
537021003023	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
537021003024	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
537021003025	catalytic residues [active]
537021003026	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
537021003027	catalytic residue [active]
537021003028	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
537021003029	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
537021003030	putative ABC transporter; Region: ycf24; CHL00085
537021003031	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
537021003032	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
537021003033	Walker A/P-loop; other site
537021003034	ATP binding site [chemical binding]; other site
537021003035	Q-loop/lid; other site
537021003036	ABC transporter signature motif; other site
537021003037	Walker B; other site
537021003038	D-loop; other site
537021003039	H-loop/switch region; other site
537021003040	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
537021003041	FeS assembly protein SufD; Region: sufD; TIGR01981
537021003042	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
537021003043	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
537021003044	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
537021003045	catalytic residue [active]
537021003046	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
537021003047	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
537021003048	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
537021003049	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
537021003050	FeS/SAM binding site; other site
537021003051	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
537021003052	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
537021003053	motif 1; other site
537021003054	dimer interface [polypeptide binding]; other site
537021003055	active site
537021003056	motif 2; other site
537021003057	motif 3; other site
537021003058	elongation factor P; Validated; Region: PRK00529
537021003059	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
537021003060	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
537021003061	RNA binding site [nucleotide binding]; other site
537021003062	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
537021003063	RNA binding site [nucleotide binding]; other site
537021003064	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
537021003065	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
537021003066	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
537021003067	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
537021003068	ligand binding site [chemical binding]; other site
537021003069	active site
537021003070	UGI interface [polypeptide binding]; other site
537021003071	catalytic site [active]
537021003072	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
537021003073	RNA/DNA hybrid binding site [nucleotide binding]; other site
537021003074	active site
537021003075	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
537021003076	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
537021003077	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
537021003078	metal binding site [ion binding]; metal-binding site
537021003079	active site
537021003080	I-site; other site
537021003081	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
537021003082	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
537021003083	F0F1 ATP synthase subunit B; Validated; Region: PRK09173
537021003084	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
537021003085	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
537021003086	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
537021003087	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
537021003088	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
537021003089	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
537021003090	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
537021003091	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
537021003092	catalytic residue [active]
537021003093	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
537021003094	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
537021003095	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
537021003096	DALR anticodon binding domain; Region: DALR_1; pfam05746
537021003097	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
537021003098	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
537021003099	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
537021003100	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
537021003101	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
537021003102	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
537021003103	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
537021003104	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
537021003105	active site
537021003106	homodimer interface [polypeptide binding]; other site
537021003107	cell division protein FtsW; Region: ftsW; TIGR02614
537021003108	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
537021003109	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
537021003110	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
537021003111	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
537021003112	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
537021003113	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
537021003114	Mg++ binding site [ion binding]; other site
537021003115	putative catalytic motif [active]
537021003116	putative substrate binding site [chemical binding]; other site
537021003117	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
537021003118	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
537021003119	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
537021003120	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
537021003121	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
537021003122	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
537021003123	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
537021003124	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
537021003125	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
537021003126	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
537021003127	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
537021003128	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
537021003129	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
537021003130	MraW methylase family; Region: Methyltransf_5; cl17771
537021003131	cell division protein MraZ; Reviewed; Region: PRK00326
537021003132	MraZ protein; Region: MraZ; pfam02381
537021003133	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
537021003134	phosphoglucomutase; Region: PLN02307
537021003135	active site
537021003136	substrate binding site [chemical binding]; other site
537021003137	metal binding site [ion binding]; metal-binding site
537021003138	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
537021003139	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
537021003140	metal ion-dependent adhesion site (MIDAS); other site
537021003141	von Willebrand factor type A domain; Region: VWA_2; pfam13519
537021003142	metal ion-dependent adhesion site (MIDAS); other site
537021003143	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
537021003144	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
537021003145	substrate binding pocket [chemical binding]; other site
537021003146	chain length determination region; other site
537021003147	catalytic residues [active]
537021003148	aspartate-rich region 1; other site
537021003149	substrate-Mg2+ binding site; other site
537021003150	active site lid residues [active]
537021003151	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
537021003152	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
537021003153	substrate binding pocket [chemical binding]; other site
537021003154	membrane-bound complex binding site; other site
537021003155	hinge residues; other site
537021003156	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
537021003157	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
537021003158	dimer interface [polypeptide binding]; other site
537021003159	conserved gate region; other site
537021003160	putative PBP binding loops; other site
537021003161	ABC-ATPase subunit interface; other site
537021003162	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
537021003163	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
537021003164	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
537021003165	active site
537021003166	NTP binding site [chemical binding]; other site
537021003167	metal binding triad [ion binding]; metal-binding site
537021003168	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
537021003169	Preprotein translocase subunit; Region: YajC; pfam02699
537021003170	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
537021003171	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
537021003172	HIGH motif; other site
537021003173	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
537021003174	active site
537021003175	KMSKS motif; other site
537021003176	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
537021003177	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
537021003178	dimer interface [polypeptide binding]; other site
537021003179	putative anticodon binding site; other site
537021003180	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
537021003181	motif 1; other site
537021003182	active site
537021003183	motif 2; other site
537021003184	motif 3; other site
537021003185	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
537021003186	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
537021003187	FeS/SAM binding site; other site
537021003188	Thiamine pyrophosphokinase; Region: TPK; cd07995
537021003189	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
537021003190	active site
537021003191	dimerization interface [polypeptide binding]; other site
537021003192	thiamine binding site [chemical binding]; other site
537021003193	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
537021003194	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
537021003195	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
537021003196	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
537021003197	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
537021003198	non-specific DNA binding site [nucleotide binding]; other site
537021003199	salt bridge; other site
537021003200	sequence-specific DNA binding site [nucleotide binding]; other site
537021003201	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
537021003202	replicative DNA helicase; Region: DnaB; TIGR00665
537021003203	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
537021003204	Walker A motif; other site
537021003205	ATP binding site [chemical binding]; other site
537021003206	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
537021003207	Protein of unknown function (DUF1376); Region: DUF1376; cl01531
537021003208	Protein of unknown function (DUF1376); Region: DUF1376; cl01531
537021003209	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
537021003210	periplasmic folding chaperone; Provisional; Region: PRK10788
537021003211	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
537021003212	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
537021003213	RNA methyltransferase, RsmE family; Region: TIGR00046
537021003214	Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572
537021003215	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
537021003216	Coenzyme A binding pocket [chemical binding]; other site
537021003217	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
537021003218	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
537021003219	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
537021003220	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
537021003221	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
537021003222	NAD binding site [chemical binding]; other site
537021003223	homotetramer interface [polypeptide binding]; other site
537021003224	homodimer interface [polypeptide binding]; other site
537021003225	substrate binding site [chemical binding]; other site
537021003226	active site
537021003227	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
537021003228	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
537021003229	FMN binding site [chemical binding]; other site
537021003230	active site
537021003231	catalytic residues [active]
537021003232	substrate binding site [chemical binding]; other site
537021003233	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
537021003234	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
537021003235	DNA photolyase; Region: DNA_photolyase; pfam00875
537021003236	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
537021003237	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
537021003238	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
537021003239	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
537021003240	nucleotide binding pocket [chemical binding]; other site
537021003241	K-X-D-G motif; other site
537021003242	catalytic site [active]
537021003243	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
537021003244	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
537021003245	Dimer interface [polypeptide binding]; other site
537021003246	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
537021003247	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
537021003248	Walker A/P-loop; other site
537021003249	ATP binding site [chemical binding]; other site
537021003250	Q-loop/lid; other site
537021003251	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
537021003252	ABC transporter signature motif; other site
537021003253	Walker B; other site
537021003254	D-loop; other site
537021003255	H-loop/switch region; other site
537021003256	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
537021003257	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
537021003258	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
537021003259	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
537021003260	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
537021003261	nucleotide binding site [chemical binding]; other site
537021003262	SulA interaction site; other site
537021003263	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
537021003264	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
537021003265	Cell division protein FtsA; Region: FtsA; smart00842
537021003266	Cell division protein FtsA; Region: FtsA; pfam14450
537021003267	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
537021003268	Cell division protein FtsQ; Region: FtsQ; pfam03799
537021003269	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
537021003270	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
537021003271	ATP-grasp domain; Region: ATP-grasp_4; cl17255
537021003272	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
537021003273	Terminase-like family; Region: Terminase_6; pfam03237
537021003274	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
537021003275	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
537021003276	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
537021003277	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
537021003278	active site
537021003279	substrate binding site [chemical binding]; other site
537021003280	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
537021003281	DNA binding site [nucleotide binding]
537021003282	active site
537021003283	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
537021003284	catalytic site [active]
537021003285	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
537021003286	VRR-NUC domain; Region: VRR_NUC; pfam08774
537021003287	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
537021003288	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
537021003289	ATP binding site [chemical binding]; other site
537021003290	putative Mg++ binding site [ion binding]; other site
537021003291	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
537021003292	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
537021003293	Guanylate kinase; Region: Guanylate_kin; pfam00625
537021003294	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
537021003295	active site
537021003296	structural protein; Region: PHA01972
537021003297	chromosome segregation protein; Provisional; Region: PRK02224
537021003298	hypothetical protein; Region: PHA00661
537021003299	hypothetical protein; Region: PHA00662
537021003300	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
537021003301	hypothetical protein; Region: PHA00670
537021003302	Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236
537021003303	Terminase-like family; Region: Terminase_6; pfam03237
537021003304	Transposase; Region: HTH_Tnp_1; cl17663
537021003305	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
537021003306	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
537021003307	non-specific DNA binding site [nucleotide binding]; other site
537021003308	salt bridge; other site
537021003309	sequence-specific DNA binding site [nucleotide binding]; other site
537021003310	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
537021003311	non-specific DNA binding site [nucleotide binding]; other site
537021003312	salt bridge; other site
537021003313	sequence-specific DNA binding site [nucleotide binding]; other site
537021003314	hypothetical protein; Provisional; Region: PRK08999
537021003315	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
537021003316	putative trimer interface [polypeptide binding]; other site
537021003317	putative CoA binding site [chemical binding]; other site
537021003318	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
537021003319	polymerase nucleotide-binding site; other site
537021003320	DNA-binding residues [nucleotide binding]; DNA binding site
537021003321	nucleotide binding site [chemical binding]; other site
537021003322	primase nucleotide-binding site [nucleotide binding]; other site
537021003323	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
537021003324	D5 N terminal like; Region: D5_N; cl07360
537021003325	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613