-- dump date 20120504_140602 -- class Genbank::misc_feature -- table misc_feature_note -- id note 192222000001 3 probable transmembrane helices predicted for Cj0014c by TMHMM2.0 at aa 12-34, 76-98 and 111-130 192222000002 5 probable transmembrane helices predicted for Cj0017c by TMHMM2.0 at aa 13-35, 50-67, 72-91, 111-133 and 154-176 192222000003 2 probable transmembrane helices predicted for Cj0019c by TMHMM2.0 at aa 10-32 and 239-261 192222000004 11 probable transmembrane helices predicted for Cj0025c by TMHMM2.0 at aa 10-29, 41-63, 83-105, 126-148,182-204, 225-247, 267-289, 302-324, 339-361, 374-396 and 401-423 192222000005 12 probable transmembrane helices predicted for Cj0035c by TMHMM2.0 at aa 13-35, 50-72, 84-106, 110-127,140-162, 167-189, 219-241, 256-278, 285-307, 317-339,346-368 and 372-394 192222000006 2 probable transmembrane helices predicted for Cj0038c by TMHMM2.0 at aa 17-39 and 43-60 192222000007 2 probable transmembrane helices predicted for Cj0062c by TMHMM2.0 at aa 7-26 and 32-54 192222000008 13 probable transmembrane helices predicted for Cj0076c by TMHMM2.0 at aa 15-37, 42-61, 76-98, 119-150,165-187, 194-216, 255-272, 297-319, 372-391, 403-425,452-474, 495-517 and 532-554 192222000009 2 probable transmembrane helices predicted for Cj0124c by TMHMM2.0 at aa 5-27 and 42-64 192222000010 7 probable transmembrane helices predicted for Cj0141c by TMHMM2.0 at aa 13-35, 55-77, 90-112, 132-150,171-200, 215-237 and 239-261 192222000011 4 probable transmembrane helices predicted for Cj0157c by TMHMM2.0 at aa 10-29, 46-68, 78-97 and 109-131 192222000012 8 probable transmembrane helices predicted for Cj0164c by TMHMM2.0 at aa 12-34, 44-63, 96-118, 138-160,165-187, 207-229, 234-256 and 271-293 192222000013 6 probable transmembrane helices predicted for Cj0167c by TMHMM2.0 at aa 4-23, 36-58, 63-85, 105-127,131-153 and 166-185 192222000014 12 probable transmembrane helices predicted for Cj0174c by TMHMM2.0 at aa 13-35, 69-91, 104-124, 144-166,187-209, 241-263, 292-314, 329-351, 371-393, 408-430,451-473 and 505-527 192222000015 7 probable transmembrane helices predicted for Cj0186c by TMHMM2.0 at aa 15-37, 50-69, 84-103, 124-146,151-173, 186-203 and 213-231 192222000016 3 probable transmembrane helices predicted for Cj0232c by TMHMM2.0 at aa 15-37, 42-64 and 94-116 192222000017 2 probable transmembrane helices predicted for Cj0235c by TMHMM2.0 at aa 5-22 and 49-71 192222000018 6 probable transmembrane helices predicted for Cj0236c by TMHMM2.0 at aa 32-54, 59-76, 89-111, 116-138,145-167 and 171-190 192222000019 12 probable transmembrane helices predicted for Cj0250c by TMHMM2.0 at aa 13-35, 55-77, 84-103, 108-130,151-173, 186-208, 238-260, 275-297, 302-324, 334-356,368-390 and 405-427 192222000020 2 probable transmembrane helices predicted for Cj0260c by TMHMM2.0 at aa 12-34 and 38-60 192222000021 2 probable transmembrane helices predicted for Cj0262c by TMHMM2.0 at aa 15-37 and 298-317 192222000022 2 probable transmembrane helices predicted for Cj0266c by TMHMM2.0 at aa 5-27 and 34-56 192222000023 2 probable transmembrane helices predicted for Cj0267c by TMHMM2.0 at aa 15-37 and 44-66 192222000024 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.8e-34 192222000025 12 probable transmembrane helices predicted for Cj0292c by TMHMM2.0 at aa 9-31, 41-63, 72-94, 98-120,141-163, 178-195, 247-269, 284-303, 310-332, 337-359,364-386 and 401-423 192222000026 5 probable transmembrane helices predicted for Cj0301c by TMHMM2.0 at aa 15-37, 49-71, 86-108, 147-169 and 195-217 192222000027 4 probable transmembrane helices predicted for Cj0309c by TMHMM2.0 at aa 3-20, 30-49, 56-78 and 84-103 192222000028 4 probable transmembrane helices predicted for Cj0310c by TMHMM2.0 at aa 7-28, 33-55, 60-82 and 86-108 192222000029 3 probable transmembrane helices predicted for Cj0337c by TMHMM2.0 at aa 28-50, 147-169 and 179-201 192222000030 4 probable transmembrane helices predicted for Cj0341c by TMHMM2.0 at aa 15-37, 44-66, 96-118 and 125-144 192222000031 9 probable transmembrane helices predicted for Cj0343c by TMHMM2.0 at aa 9-31, 41-63, 75-92, 97-119,131-148, 152-169, 174-193, 203-225 and 237-259 192222000032 5 probable transmembrane helices predicted for Cj0357c by TMHMM2.0 at aa 5-27, 85-107, 117-139, 144-163 and 173-195 192222000033 13 probable transmembrane helices predicted for Cj0366c by TMHMM2.0 at aa 10-32, 342-361, 366-388,393-415, 445-467, 479-501, 516-533, 540-562, 866-883,890-912, 922-944, 965-987 and 1002-1024 192222000034 5 probable transmembrane helices predicted for Cj0369c by TMHMM2.0 at aa 13-31, 58-80, 127-149, 164-186 and 300-322 192222000035 6 probable transmembrane helices predicted for Cj0378c by TMHMM2.0 at aa 7-26, 36-55, 67-86, 101-123,135-149 and 153-171 192222000036 10 probable transmembrane helices predicted for Cj0385c by TMHMM2.0 at aa 9-28, 38-56, 65-87, 97-116,121-143, 156-173, 185-207, 217-239, 259-281 and 285-304 192222000037 6 probable transmembrane helices predicted for Cj0421c by TMHMM2.0 at aa 2-24, 48-70, 82-99, 122-139,146-163 and 173-192 192222000038 10 probable transmembrane helices predicted for Cj0433c by TMHMM2.0 at aa 20-42, 63-85, 90-108, 129-147,162-184, 189-211, 226-248, 255-277, 282-304 and 331-350 192222000039 2 probable transmembrane helices predicted for Cj0457c by TMHMM2.0 at aa 7-24 and 39-58 192222000040 12 probable transmembrane helices predicted for Cj0461c by TMHMM2.0 at aa 21-43, 48-70, 77-99, 103-122,143-165, 169-191, 211-233, 248-270, 282-299, 303-325,346-368 and 372-391 192222000041 9 probable transmembrane helices predicted for Cj0557c by TMHMM2.0 at aa 23-45, 47-66, 86-108, 115-137,152-174, 187-209, 219-240, 283-302 and 317-339 192222000042 5 probable transmembrane helices predicted for Cj0578c by TMHMM2.0 at aa 16-38, 71-93, 105-127, 160-182 and 195-217 192222000043 7 probable transmembrane helices predicted for Cj0593c by TMHMM2.0 at aa 5-27, 34-56, 69-87, 92-114,119-141, 153-172 and 176-195 192222000044 11 probable transmembrane helices predicted for Cj0601c by TMHMM2.0 at aa 5-27, 37-59, 87-109, 135-157,168-190, 217-239, 252-274, 296-318, 339-361, 381-403 and 424-446 192222000045 8 probable transmembrane helices predicted for Cj0603c by TMHMM2.0 at aa 177-199, 211-233, 248-270,290-321, 331-353, 365-382, 386-405 and 418-437 192222000046 11 probable transmembrane helices predicted for Cj0611c by TMHMM2.0 at aa 5-22, 32-66, 73-95, 110-132,144-163, 183-205, 236-258, 319-341, 348-370, 396-415 and 422-444 192222000047 12 probable transmembrane helices predicted for Cj0654c by TMHMM2.0 at aa 44-66, 76-95, 100-122, 137-159,166-188, 215-237, 249-267, 277-296, 350-372, 392-414,427-446 and 456-478 192222000048 4 probable transmembrane helices predicted for Cj0721c by TMHMM2.0 at aa 7-29, 49-68, 88-110 and 125-147 192222000049 7 probable transmembrane helices predicted for Cj0723c by TMHMM2.0 at aa 4-26, 61-83, 93-115, 138-160,164-186, 279-301 and 311-333 192222000050 2 probable transmembrane helices predicted for Cj0726c by TMHMM2.0 at aa 267-289 and 299-321 192222000051 7 probable transmembrane helices predicted for Cj0773c by TMHMM2.0 at aa 57-79, 92-114, 119-141, 184-206,226-248, 260-277 and 282-301 192222000052 3 probable transmembrane helices predicted for Cj0795c by TMHMM2.0 at aa 7-29, 49-71 and 95-117 192222000053 3 probable transmembrane helices predicted for Cj0808c by TMHMM2.0 at aa 5-26, 47-69 and 74-96 192222000054 5 probable transmembrane helices predicted for Cj0820c by TMHMM2.0 at aa 4-26, 39-61, 76-98, 184-206 and 216-235 192222000055 13 probable transmembrane helices predicted for Cj0832c by TMHMM2.0 at aa 22-44, 49-71, 106-128, 149-171,186-208, 220-237, 242-259, 306-328, 358-377, 390-412,434-456, 530-547 and 551-573 192222000056 2 probable transmembrane helices predicted for Cj0844c by TMHMM2.0 at aa 7-29 and 67-89 192222000057 12 probable transmembrane helices predicted for Cj0850c by TMHMM2.0 at aa 12-34, 44-63, 70-89, 99-121,134-156, 160-179, 204-226, 236-258, 265-284, 288-310,330-352 and 357-379 192222000058 4 probable transmembrane helices predicted for Cj0851c by TMHMM2.0 at aa 7-22, 32-54, 104-126 and 136-158 192222000059 2 probable transmembrane helices predicted for Cj0852c by TMHMM2.0 at aa 29-51 and 61-79 192222000060 7 probable transmembrane helices predicted for Cj0882c by TMHMM2.0 at aa 21-43, 48-70, 82-102, 122-144,214-236, 251-273 and 298-320 192222000061 3 probable transmembrane helices predicted for Cj0886c by TMHMM2.0 at aa 13-35, 50-72 and 85-107 192222000062 2 probable transmembrane helices predicted for Cj0889c by TMHMM2.0 at aa 7-26 and 134-156 192222000063 9 probable transmembrane helices predicted for Cj0903c by TMHMM2.0 at aa 27-49, 85-107, 149-171, 199-221,231-253, 323-345, 371-393, 405-422 and 437-459 192222000064 16 probable transmembrane helices predicted for Cj0917c by TMHMM2.0 at aa 7-26, 36-58, 87-109, 119-138,159-181, 191-213, 218-240, 255-277, 284-306, 321-343,364-386, 465-487, 508-530, 540-562, 575-594 and 661-683 192222000065 3 probable transmembrane helices predicted for Cj0919c by TMHMM2.0 at aa 23-45, 66-88 and 186-208 192222000066 3 probable transmembrane helices predicted for Cj0920c by TMHMM2.0 at aa 47-69, 90-112 and 214-236 192222000067 11 probable transmembrane helices predicted for Cj0934c by TMHMM2.0 at aa 7-25, 35-57, 87-109, 133-155,167-189, 216-238, 251-273, 298-320, 341-363, 383-402 and 423-445 192222000068 11 probable transmembrane helices predicted for Cj0935c by TMHMM2.0 at aa 7-25, 40-62, 83-105, 139-161,174-196, 216-238, 251-273, 299-321, 342-364, 384-401 and 421-443 192222000069 13 probable transmembrane helices predicted for Cj0938c by TMHMM2.0 at aa 7-29, 49-71, 84-103, 107-129,142-164, 179-201, 239-258, 273-295, 304-326, 330-352,365-387, 391-413 and 779-801 192222000070 6 probable transmembrane helices predicted for Cj0940c by TMHMM2.0 at aa 26-48, 68-90, 102-124, 134-156,177-199 and 233-255 192222000071 4 probable transmembrane helices predicted for Cj0941c by TMHMM2.0 at aa 21-43, 266-288, 314-336 and 362-384 192222000072 6 probable transmembrane helices predicted for Cj0948c by TMHMM2.0 at aa 7-29, 33-55, 75-97, 112-134,146-168 and 172-194 192222000073 2 probable transmembrane helices predicted for Cj0952c by TMHMM2.0 at aa 10-32 and 175-197 192222000074 5 probable transmembrane helices predicted for Cj0958c by TMHMM2.0 at aa 13-32, 332-354, 400-422, 442-459 and 479-501 192222000075 12 probable transmembrane helices predicted for Cj0981c by TMHMM2.0 at aa 7-29, 44-66, 79-98, 103-122,142-164, 179-198, 232-254, 269-291, 298-315, 320-342,354-376 and 380-399 192222000076 2 probable transmembrane helices predicted for Cj0986c by TMHMM2.0 at aa 2-19 and 29-51 192222000077 9 probable transmembrane helices predicted for Cj0987c by TMHMM2.0 at aa 12-31, 51-73, 80-97, 103-125,134-156, 171-188, 212-234, 256-273 and 285-307 192222000078 11 probable transmembrane helices predicted for Cj0999c by TMHMM2.0 at aa 12-34, 44-63, 83-100, 105-127,134-153, 163-185, 197-219, 234-256, 269-288, 303-325 and 338-360 192222000079 5 probable transmembrane helices predicted for Cj1003c by TMHMM2.0 at aa 7-29, 44-66, 73-95, 105-124 and 131-153 192222000080 2 probable transmembrane helices predicted for Cj1005c by TMHMM2.0 at aa 6-23 and 88-110 192222000081 3 probable transmembrane helices predicted for Cj1007c by TMHMM2.0 at aa 221-243, 264-286 and 301-320 192222000082 12 probable transmembrane helices predicted for Cj1013c by TMHMM2.0 at aa 13-32, 47-66, 78-100, 771-793,805-827, 837-859, 864-883, 910-932, 953-975, 990-1008,1015-1037 and 1052-1071 192222000083 8 probable transmembrane helices predicted for Cj1016c by TMHMM2.0 at aa 7-29, 34-51, 58-80, 104-126,133-155, 170-191, 257-279 and 307-324 192222000084 7 probable transmembrane helices predicted for Cj1017c by TMHMM2.0 at aa 15-37, 58-80, 95-117, 138-160,191-213, 234-256 and 271-293 192222000085 4 probable transmembrane helices predicted for Cj1022c by TMHMM2.0 at aa 13-35, 63-85, 119-136 and 146-163 192222000086 12 probable transmembrane helices predicted for Cj1040c by TMHMM2.0 at aa 7-29, 44-66, 73-92, 96-118,131-153, 157-179, 206-228, 238-260, 267-289, 295-317,330-349 and 359-381 192222000087 6 probable transmembrane helices predicted for Cj1049c by TMHMM2.0 at aa 5-27, 40-62, 66-88, 109-131,141-163 and 168-190 192222000088 2 probable transmembrane helices predicted for Cj1053c by TMHMM2.0 at aa 5-22 and 32-49 192222000089 5 probable transmembrane helices predicted for Cj1055c by TMHMM2.0 at aa 5-27, 55-77, 90-112, 149-171 and 178-200 192222000090 4 probable transmembrane helices predicted for Cj1092c by TMHMM2.0 at aa 13-35, 137-154, 236-258 and 268-290 192222000091 4 probable transmembrane helices predicted for Cj1093c by TMHMM2.0 at aa 7-29, 359-381, 388-410 and 482-504 192222000092 6 probable transmembrane helices predicted for Cj1111c by TMHMM2.0 at aa 7-29, 44-66, 79-101, 119-141,148-170 and 185-202 192222000093 8 probable transmembrane helices predicted for Cj1114c by TMHMM2.0 at aa 7-29, 33-55, 75-92, 97-114,126-148, 158-175, 188-207 and 211-233 192222000094 2 probable transmembrane helices predicted for Cj1116c by TMHMM2.0 at aa 22-41 and 128-147 192222000095 4 probable transmembrane helices predicted for Cj1119c by TMHMM2.0 at aa 161-183, 196-218, 239-261 and 266-288 192222000096 3 probable transmembrane helices predicted for Cj1120c by TMHMM2.0 at aa 9-28, 38-60 and 80-102 192222000097 3 probable transmembrane helices predicted for Cj1122c by TMHMM2.0 at aa 33-52, 73-95 and 115-137 192222000098 11 probable transmembrane helices predicted for Cj1126c by TMHMM2.0 at aa 12-34, 97-119, 126-143, 153-170,177-194, 198-215, 222-244, 259-281, 329-347, 373-390 and 403-425 192222000099 6 probable transmembrane helices predicted for Cj1130c by TMHMM2.0 at aa 20-42, 63-85, 146-168, 175-197,261-280 and 287-304 192222000100 8 probable transmembrane helices predicted for Cj1155c by TMHMM2.0 at aa 166-188, 198-215, 235-254,259-277, 410-432, 447-469, 741-760 and 764-781 192222000101 2 probable transmembrane helices predicted for Cj1158c by TMHMM2.0 at aa 21-43 and 53-71 192222000102 8 probable transmembrane helices predicted for Cj1161c by TMHMM2.0 at aa 88-105, 115-137, 144-166,171-190, 328-345, 360-382, 650-672 and 677-694 192222000103 6 probable transmembrane helices predicted for Cj1163c by TMHMM2.0 at aa 40-62, 72-91, 104-126, 141-163,176-198 and 202-224 192222000104 5 probable transmembrane helices predicted for Cj1165c by TMHMM2.0 at aa 4-23, 30-48, 53-75, 87-109 and 129-151 192222000105 5 probable transmembrane helices predicted for Cj1166c by TMHMM2.0 at aa 120-139, 144-161, 168-187,197-216 and 229-251 192222000106 4 probable transmembrane helices predicted for Cj1168c by TMHMM2.0 at aa 13-35, 55-77, 139-161 and 171-193 192222000107 7 probable transmembrane helices predicted for Cj1179c by TMHMM2.0 at aa 13-32, 37-59, 72-94, 116-138,143-162, 177-199 and 211-233 192222000108 2 probable transmembrane helices predicted for Cj1184c by TMHMM2.0 at aa 7-29 and 346-365 192222000109 10 probable transmembrane helices predicted for Cj1185c by TMHMM2.0 at aa 39-61, 95-117, 124-146, 156-178,191-213, 258-280, 301-320, 325-344, 357-376 and 386-408 192222000110 11 probable transmembrane helices predicted for Cj1187c by TMHMM2.0 at aa 20-42, 57-79, 103-134, 144-166,189-211, 226-248, 255-271, 281-303, 324-346, 366-395 and 408-427 192222000111 2 probable transmembrane helices predicted for Cj1203c by TMHMM2.0 at aa 2-24 and 29-51 192222000112 6 probable transmembrane helices predicted for Cj1204c by TMHMM2.0 at aa 15-37, 76-98, 103-122, 134-156,176-198 and 205-222 192222000113 6 probable transmembrane helices predicted for Cj1212c by TMHMM2.0 at aa 20-42, 86-108, 123-145, 157-176,191-213 and 220-242 192222000114 2 probable transmembrane helices predicted for Cj1222c by TMHMM2.0 at aa 5-27 and 159-178 192222000115 2 probable transmembrane helices predicted for Cj1226c by TMHMM2.0 at aa 6-28 and 135-157 192222000116 2 probable transmembrane helices predicted for Cj1245c by TMHMM2.0 at aa 2-19 and 34-51 192222000117 12 probable transmembrane helices predicted for Cj1257c by TMHMM2.0 at aa 7-29, 44-66, 78-100, 104-126,133-155, 165-187, 207-229, 239-261, 273-295, 300-322,343-360 and 364-383 192222000118 4 probable transmembrane helices predicted for Cj1265c by TMHMM2.0 at aa 25-44, 64-86, 131-153 and 186-208 192222000119 4 probable transmembrane helices predicted for Cj1276c by TMHMM2.0 at aa 7-29, 143-165, 199-221 and 241-263 192222000120 7 probable transmembrane helices predicted for Cj1347c by TMHMM2.0 at aa 10-41, 48-67, 71-88, 95-114,119-138, 159-181 and 185-204 192222000121 3 probable transmembrane helices predicted for Cj1356c by TMHMM2.0 at aa 13-35, 131-153 and 166-183 192222000122 3 probable transmembrane helices predicted for Cj1412c by TMHMM2.0 at aa 115-137, 142-164 and 341-363 192222000123 2 probable transmembrane helices predicted for Cj1445c by TMHMM2.0 at aa 22-44 and 346-368 192222000124 6 probable transmembrane helices predicted for Cj1448c by TMHMM2.0 at aa 24-46, 56-78, 107-129, 144-166,171-193 and 227-249 192222000125 4 probable transmembrane helices predicted for Cj1470c by TMHMM2.0 at aa 156-178, 209-231, 246-268 and 357-379 192222000126 2 probable transmembrane helices predicted for Cj1484c by TMHMM2.0 at aa 9-31 and 169-188 192222000127 2 probable transmembrane helices predicted for Cj1487c by TMHMM2.0 at aa 10-30 and 63-85 192222000128 12 probable transmembrane helices predicted for Cj1490c by TMHMM2.0 at aa 13-35, 60-82, 102-124, 134-156,163-182, 216-238, 251-273, 283-305, 317-339, 354-376,396-418 and 438-460 192222000129 6 probable transmembrane helices predicted for Cj1493c by TMHMM2.0 at aa 13-35, 50-72, 79-101, 130-152,159-181 and 196-218 192222000130 12 probable transmembrane helices predicted for Cj1502c by TMHMM2.0 at aa 13-35, 80-102, 133-155, 165-187,200-222, 237-259, 280-302, 330-352, 373-395, 405-427,434-453 and 458-480 192222000131 2 probable transmembrane helices predicted for Cj1506c by TMHMM2.0 at aa 7-29 and 328-350 192222000132 6 probable transmembrane helices predicted for Cj1509c by TMHMM2.0 at aa 5-24, 56-78, 99-121, 136-156,194-216 and 240-262 192222000133 5 probable transmembrane helices predicted for Cj1539c by TMHMM2.0 at aa 43-65, 72-94, 109-131, 165-187 and 212-234 192222000134 10 probable transmembrane helices predicted for Cj1544c by TMHMM2.0 at aa 7-24, 34-56, 69-88, 98-120,133-150, 155-177, 186-205, 220-242, 247-269 and 273-295 192222000135 12 probable transmembrane helices predicted for Cj1566c by TMHMM2.0 at aa 13-35, 42-64, 79-98, 111-133,162-184, 205-227, 237-259, 266-288, 323-345, 365-387,397-419 and 439-461 192222000136 14 probable transmembrane helices predicted for Cj1567c by TMHMM2.0 at aa 4-20, 27-49, 69-91, 98-115,119-141, 148-170, 200-222, 229-251, 261-283, 290-312,317-339, 359-381, 394-416 and 437-459 192222000137 16 probable transmembrane helices predicted for Cj1568c by TMHMM2.0 at aa 4-23, 30-52, 76-98, 105-124,128-150, 163-182, 202-224, 236-258, 268-290, 297-319,323-342, 363-385, 398-420, 441-463, 478-500 and 573-595 192222000138 3 probable transmembrane helices predicted for Cj1569c by TMHMM2.0 at aa 5-21, 26-48 and 58-80 192222000139 5 probable transmembrane helices predicted for Cj1570c by TMHMM2.0 at aa 5-24, 28-47, 54-76, 91-110 and 141-163 192222000140 8 probable transmembrane helices predicted for Cj1572c by TMHMM2.0 at aa 10-32, 78-100, 120-142, 155-177,192-214, 246-268, 272-294 and 311-330 192222000141 3 probable transmembrane helices predicted for Cj1579c by TMHMM2.0 at aa 10-32, 69-91 and 96-118 192222000142 6 probable transmembrane helices predicted for Cj1582c by TMHMM2.0 at aa 7-29, 69-91, 103-122, 126-145,176-198 and 231-253 192222000143 6 probable transmembrane helices predicted for Cj1583c by TMHMM2.0 at aa 5-24, 96-118, 131-153, 179-198,236-258 and 278-300 192222000144 3 probable transmembrane helices predicted for Cj1587c by TMHMM2.0 at aa 13-35, 50-72 and 138-160 192222000145 12 probable transmembrane helices predicted for Cj1588c by TMHMM2.0 at aa 13-35, 50-72, 85-107, 117-139,151-173, 183-205, 241-263, 278-300, 305-327, 332-354,367-389 and 404-426 192222000146 11 probable transmembrane helices predicted for Cj1625c by TMHMM2.0 at aa 13-35, 39-56, 84-106, 130-152,159-181, 201-223, 243-265, 291-313, 334-351, 361-383 and 395-412 192222000147 11 probable transmembrane helices predicted for Cj1654c by TMHMM2.0 at aa 12-34, 61-83, 96-118, 128-145,157-179, 183-205, 218-240, 260-282, 293-315, 330-352 and 365-387 192222000148 10 probable transmembrane helices predicted for Cj1655c by TMHMM2.0 at aa 16-38, 58-80, 92-114, 124-146,153-175, 180-199, 206-228, 289-311, 324-346 and 361-378 192222000149 11 probable transmembrane helices predicted for Cj1684c by TMHMM2.0 at aa 10-27, 34-56, 61-83, 96-129,149-171, 184-206, 232-254, 275-292, 302-324, 333-355 and 365-387 192222000150 10 probable transmembrane helices predicted for Cj1688c by TMHMM2.0 at aa 9-31, 61-83, 104-126, 141-163,170-191, 206-228, 257-279, 299-321, 357-376 and 381-398 192222000151 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 192222000152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 192222000153 Walker A motif; other site 192222000154 ATP binding site [chemical binding]; other site 192222000155 Walker B motif; other site 192222000156 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 192222000157 DnaA box-binding interface [nucleotide binding]; other site 192222000158 HMMPfam hit to PF00308, Bacterial dnaA protein,score 4.2e-124 192222000159 PS00017 ATP/GTP-binding site motif A (P-loop) 192222000160 DNA polymerase III subunit beta; Validated; Region: PRK05643 192222000161 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 192222000162 putative DNA binding surface [nucleotide binding]; other site 192222000163 dimer interface [polypeptide binding]; other site 192222000164 beta-clamp/clamp loader binding surface; other site 192222000165 beta-clamp/translesion DNA polymerase binding surface; other site 192222000166 HMMPfam hit to PF00712, DNA polymerase III beta subunit, N-te, score 1.9e-11 192222000167 HMMPfam hit to PF02767, DNA polymerase III beta subunit, cent, score 4e-11 192222000168 HMMPfam hit to PF02768, DNA polymerase III beta subunit, C-te, score 2.7e-05 192222000169 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 192222000170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 192222000171 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 192222000172 anchoring element; other site 192222000173 dimer interface [polypeptide binding]; other site 192222000174 ATP binding site [chemical binding]; other site 192222000175 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 192222000176 active site 192222000177 putative metal-binding site [ion binding]; other site 192222000178 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 192222000179 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and H, score 1.1e-30 192222000180 HMMPfam hit to PF00204, DNA gyrase B, score 6.7e-81 192222000181 HMMPfam hit to PF01751, Toprim domain, score 1e-08 192222000182 PS00177 DNA topoisomerase II signature 192222000183 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000184 HMMPfam hit to PF00986, DNA gyrase B subunit,carboxyl terminus, score 3.1e-43 192222000185 quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908 192222000186 PS00190 Cytochrome c family heme-binding site signature 192222000187 sulfite oxidase; Provisional; Region: PLN00177 192222000188 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 192222000189 Moco binding site; other site 192222000190 metal coordination site [ion binding]; other site 192222000191 dimerization interface [polypeptide binding]; other site 192222000192 HMMPfam hit to PF03404, Mo-co oxidoreductase dimerisation doma, score 6.8e-19 192222000193 HMMPfam hit to PF00174, Oxidoreductase molybdopterin binding d, score 2.1e-14 192222000194 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000195 1 probable transmembrane helix predicted for Cj0005c by TMHMM2.0 at aa 13-32 192222000196 Predicted permease [General function prediction only]; Region: COG2056 192222000197 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 192222000198 11 probable transmembrane helices predicted for Cj0006 by TMHMM2.0 at aa 10-44, 65-87, 115-134, 146-168,188-210, 236-253, 257-275, 288-305, 327-349, 361-383 and 412-434 192222000199 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000200 HMMPfam hit to PF03553, Na+/H+ antiporter family,score 4.4e-90 192222000201 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 192222000202 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 192222000203 active site 192222000204 dimer interface [polypeptide binding]; other site 192222000205 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 192222000206 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 192222000207 active site 192222000208 FMN binding site [chemical binding]; other site 192222000209 substrate binding site [chemical binding]; other site 192222000210 3Fe-4S cluster binding site [ion binding]; other site 192222000211 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 192222000212 domain interface; other site 192222000213 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 5.9e-222 192222000214 HMMPfam hit to PF04898, Glutamate synthase central domain, score 1.8e-181 192222000215 HMMPfam hit to PF01645, Conserved region in glutamate synthas, score 1e-224 192222000216 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000217 HMMPfam hit to PF01493, GXGXG motif, score 4.1e-72 192222000218 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature 192222000219 Protein of unknown function DUF262; Region: DUF262; cl14890 192222000220 HMMPfam hit to PF03235, Protein of unknown function DUF262, score 0.00029 192222000221 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 192222000222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222000223 NAD(P) binding site [chemical binding]; other site 192222000224 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreducta, score 2.4e-23 192222000225 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000226 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000227 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 192222000228 RNA/DNA hybrid binding site [nucleotide binding]; other site 192222000229 active site 192222000230 HMMPfam hit to PF01351, Ribonuclease HII, score 7.2e-39 192222000231 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000232 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 192222000233 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 192222000234 HMMPfam hit to PF00633, Helix-hairpin-helix motif,score 2.1 192222000235 HMMPfam hit to PF00633, Helix-hairpin-helix motif,score 1.5e-06 192222000236 1 probable transmembrane helix predicted for Cj0011c by TMHMM2.0 at aa 4-26 192222000237 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 192222000238 non-heme iron binding site [ion binding]; other site 192222000239 dimer interface [polypeptide binding]; other site 192222000240 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 192222000241 binuclear metal center [ion binding]; other site 192222000242 HMMPfam hit to PF00301, Rubredoxin, score 1.9e-05 192222000243 HMMPfam hit to PF02915, Rubrerythrin, score 6e-43 192222000244 HMMPfam hit to PF06397, Desulfoferrodoxin,N-terminal domain, score 4.4e-20 192222000245 Dehydratase family; Region: ILVD_EDD; cl00340 192222000246 HMMPfam hit to PF00920, Dehydratase family, score 0 192222000247 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1 192222000248 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2 192222000249 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 192222000250 HMMPfam hit to PF07274, Protein of unknown function (DUF1440), score 1.1e-96 192222000251 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 192222000252 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 192222000253 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 192222000254 Ligand Binding Site [chemical binding]; other site 192222000255 HMMPfam hit to PF06508, ExsB, score 4.4e-41 192222000256 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 192222000257 PS00017 ATP/GTP-binding site motif A (P-loop) 192222000258 HMMPfam hit to PF02600, Disulfide bond formation protein DsbB, score 1.9e-17 192222000259 1 probable transmembrane helix predicted for Cj0018c by TMHMM2.0 at aa 25-44 192222000260 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 192222000261 dimer interface [polypeptide binding]; other site 192222000262 putative CheW interface [polypeptide binding]; other site 192222000263 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 5.5e-10 192222000264 HMMPfam hit to PF00672, HAMP domain, score 1.8e-06 192222000265 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 192222000266 HMMPfam hit to PF00034, Cytochrome c, score 0.0083 192222000267 PS00190 Cytochrome c family heme-binding site signature 192222000268 HMMPfam hit to PF03150, Di-haem cytochrome c peroxidase, score 3.8e-69 192222000269 PS00190 Cytochrome c family heme-binding site signature 192222000270 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 192222000271 HMMPfam hit to PF01557, Fumarylacetoacetate (FAA) hydrolase fam, score 1.4e-44 192222000272 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 192222000273 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 192222000274 active site 192222000275 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 7.1e-43 192222000276 PS01129 Rlu family of pseudouridine synthase signature 192222000277 adenylosuccinate lyase; Provisional; Region: PRK08470 192222000278 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 192222000279 tetramer interface [polypeptide binding]; other site 192222000280 active site 192222000281 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 192222000282 HMMPfam hit to PF00206, Lyase, score 3.7e-45 192222000283 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000284 PS00163 Fumarate lyases signature 192222000285 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08447 192222000286 ATP cone domain; Region: ATP-cone; pfam03477 192222000287 Class I ribonucleotide reductase; Region: RNR_I; cd01679 192222000288 active site 192222000289 dimer interface [polypeptide binding]; other site 192222000290 catalytic residues [active] 192222000291 effector binding site; other site 192222000292 R2 peptide binding site; other site 192222000293 HMMPfam hit to PF03477, ATP cone domain, score 6.2e-18 192222000294 HMMPfam hit to PF00317, Ribonucleotide reductase,all-alpha d, score 3.2e-35 192222000295 HMMPfam hit to PF02867, Ribonucleotide reductase,barrel doma, score 7.5e-129 192222000296 PS00089 Ribonucleotide reductase large subunit signature 192222000297 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 192222000298 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 2.4e-40 192222000299 Thymidylate synthase complementing protein; Region: Thy1; cl03630 192222000300 HMMPfam hit to PF02511, Thymidylate synthase complementing protein, score 6.3e-43 192222000301 CTP synthetase; Validated; Region: pyrG; PRK05380 192222000302 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 192222000303 Catalytic site [active] 192222000304 active site 192222000305 UTP binding site [chemical binding]; other site 192222000306 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 192222000307 active site 192222000308 putative oxyanion hole; other site 192222000309 catalytic triad [active] 192222000310 HMMPfam hit to PF06418, CTP synthase N-terminus,score 4.3e-204 192222000311 1 probable transmembrane helix predicted for Cj0027 by TMHMM2.0 at aa 7-29 192222000312 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 3.5e-57 192222000313 PS00442 Glutamine amidotransferases class-I active site 192222000314 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 192222000315 DHH family; Region: DHH; pfam01368 192222000316 DHHA1 domain; Region: DHHA1; pfam02272 192222000317 HMMPfam hit to PF01368, DHH family, score 1e-48 192222000318 HMMPfam hit to PF02272, DHHA1 domain, score 1.5e-16 192222000319 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 192222000320 active site 192222000321 homodimer interface [polypeptide binding]; other site 192222000322 homotetramer interface [polypeptide binding]; other site 192222000323 PS00144 Asparaginase / glutaminase active site signature 1 192222000324 HMMPfam hit to PF00710, Asparaginase, score 1.5e-132 192222000325 PS00917 Asparaginase / glutaminase active site signature 2 192222000326 Protein of unknown function DUF91; Region: DUF91; cl00709 192222000327 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 192222000328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222000329 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 192222000330 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 192222000331 6 probable transmembrane helices predicted for Cj0033 by TMHMM2.0 at aa 371-393, 415-434, 467-489,494-513, 518-537 and 557-579 192222000332 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000333 Protein of unknown function (DUF541); Region: SIMPL; cl01077 192222000334 HMMPfam hit to PF04402, Protein of unknown function (DUF541), score 2.4e-60 192222000335 1 probable transmembrane helix predicted for Cj0034c by TMHMM2.0 at aa 5-23 192222000336 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 192222000337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 192222000338 putative substrate translocation pore; other site 192222000339 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000340 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.8e-52 192222000341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 192222000342 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 192222000343 Cytochrome c [Energy production and conversion]; Region: COG3258 192222000344 Cytochrome c; Region: Cytochrom_C; cl11414 192222000345 Cytochrome c; Region: Cytochrom_C; cl11414 192222000346 HMMPfam hit to PF00034, Cytochrome c, score 0.0012 192222000347 PS00190 Cytochrome c family heme-binding site signature 192222000348 PS00190 Cytochrome c family heme-binding site signature 192222000349 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 192222000350 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 192222000351 G1 box; other site 192222000352 putative GEF interaction site [polypeptide binding]; other site 192222000353 GTP/Mg2+ binding site [chemical binding]; other site 192222000354 Switch I region; other site 192222000355 G2 box; other site 192222000356 G3 box; other site 192222000357 Switch II region; other site 192222000358 G4 box; other site 192222000359 G5 box; other site 192222000360 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 192222000361 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 192222000362 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 7.8e-30 192222000363 HMMPfam hit to PF03144, Elongation factor Tu domain, score 6.7e-12 192222000364 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 6.7e-70 192222000365 PS00301 GTP-binding elongation factors signature 192222000366 PS00017 ATP/GTP-binding site motif A (P-loop) 192222000367 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 192222000368 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 192222000369 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 192222000370 FlgD Ig-like domain; Region: FlgD_ig; cl15790 192222000371 HMMPfam hit to PF03963, Flagellar hook capping protein, score 1.4e-60 192222000372 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 192222000373 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 192222000374 HMMPfam hit to PF00460, Flagella basal body rod protein, score 1.4e-08 192222000375 PS00588 Flagella basal body rod proteins signature 192222000376 HMMPfam hit to PF07559, Flagellar basal body protein FlaE, score 1.9e-29 192222000377 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 8.8e-18 192222000378 Protein of unknown function (DUF342); Region: DUF342; pfam03961 192222000379 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 192222000380 octamerization interface [polypeptide binding]; other site 192222000381 diferric-oxygen binding site [ion binding]; other site 192222000382 HMMPfam hit to PF01814, Hemerythrin HHE cation binding domain, score 0.0046 192222000383 HMMPfam hit to PF01814, Hemerythrin HHE cation binding domain, score 0.0029 192222000384 Original (2000) note: Cj0046, probable transmembrane transport protein pseudogene, len: 1559 bp; fragmentary similarity in all three reading frames to members of the SODIT1 subfamily of the NADC/P/PHO87 family of transporters e.g. SOT1_SPIOL 2-oxoglutarate/malate translocator precursor (spinach) (569 aa), fasta scores; opt: 278 z-score: 498.4 E(): 1.7e-20, 45.0% identity in 80 aa overlap, and YBHI_ECOLI (477 aa) fasta scores; opt: 196 z-score: 361.3 E(): 7.2e-13, 34.6% identity in 78 aa overlap. No Hp match; Updated (2006) note: Pfam domain PF00939 Sodium:sulfate symporter transmembrane identified within CDS. Also, ten probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. No specific characterisation with acceptable identity scores yet. Thus, added to product function. Coding sequence has been updated to reflect the complete amino acid sequence for the encoded protein regardless of its expression. This will cause differences from the amino acid sequence of the previous annotation. Functional classification - Transport/binding proteins - Other 192222000385 HMMPfam hit to PF00939, Sodium:sulfate symporter transmembrane, score 8.5e-118 192222000386 10 probable transmembrane helices predicted for Cj0046 by TMHMM2.0 at aa 10-32, 64-86, 208-230, 260-282,287-309, 318-340, 355-377, 384-406, 411-433 and 440-462 192222000387 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 192222000388 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 192222000389 Ligand Binding Site [chemical binding]; other site 192222000390 HMMPfam hit to PF03054, tRNA methyl transferase,score 1.3e-132 192222000391 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 192222000392 HMMPfam hit to PF03641, Possible lysine decarboxylase, score 2.2e-53 192222000393 PS01164 Copper amine oxidase topaquinone signature 192222000394 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39G; cd02423 192222000395 putative active site [active] 192222000396 HMMPfam hit to PF03412, Peptidase C39 family, score 4.5e-11 192222000397 flagellar motor switch protein FliY; Validated; Region: PRK08432 192222000398 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 192222000399 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 6.1e-24 192222000400 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 192222000401 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 192222000402 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 0.00022 192222000403 HMMPfam hit to PF02154, Flagellar motor switch protein FliM, score 8.3e-105 192222000404 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 192222000405 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 192222000406 HMMPfam hit to PF04545, Sigma-70, region, score 5.8e-19 192222000407 PS00716 Sigma-70 factors family signature 2 192222000408 HMMPfam hit to PF04542, Sigma-70 region, score 3.3e-12 192222000409 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 192222000410 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222000411 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 192222000412 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 5.8e-21 192222000413 PS00017 ATP/GTP-binding site motif A (P-loop) 192222000414 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 192222000415 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222000416 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 1.9e-40 192222000417 PS00017 ATP/GTP-binding site motif A (P-loop) 192222000418 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 192222000419 catalytic center binding site [active] 192222000420 ATP binding site [chemical binding]; other site 192222000421 HMMPfam hit to PF01288,7,8-dihydro-6-hydroxymethylpterin-pyrophosph, score 3.1e-25 192222000422 PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature 192222000423 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 192222000424 trimer interface [polypeptide binding]; other site 192222000425 active site 192222000426 dimer interface [polypeptide binding]; other site 192222000427 HMMPfam hit to PF01220, Dehydroquinase class II,score 1.4e-74 192222000428 chlorohydrolase; Provisional; Region: PRK08418 192222000429 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312 192222000430 active site 192222000431 HMMPfam hit to PF01979, Amidohydrolase family,score 1.8e-68 192222000432 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 192222000433 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 192222000434 tandem repeat interface [polypeptide binding]; other site 192222000435 oligomer interface [polypeptide binding]; other site 192222000436 active site residues [active] 192222000437 1 probable transmembrane helix predicted for Cj0068 by TMHMM2.0 at aa 13-35 192222000438 HMMPfam hit to PF01343, Peptidase family S49, score 1.4e-74 192222000439 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 192222000440 Original (2000) note: Cj0072c, possible iron-binding protein pseudogene, len: 98 aa; Weak similarity to members of the eukaryotic iron-binding hemerythrin family, e.g. HEMM_THEZO myohemerythrin (118 aa). Note that all of the iron-binding residues are conserved. No Hp match. Also similar to N-terminus of Cj1224 (50.5% identity in 91 aa overlap), Cj0241c (40.5% identity in 79 aa overlap) and Cj0045c (32.5% identity in 83 aa overlap). Contains one frameshift; Updated (2006) note: Pfam domains x2 PF01814 Hemerythrin HHE cation binding domain identified within CDS. Further support given to product function. Similar to many Campylobacter species designated as methy-accepting chemotaxis protein and also iron-binding proteins. No specific characterisation with acceptable identity score has been carried out yet. Thus, kept within product function. Coding sequence has been updated to reflect the complete amino acid sequence for the encoded protein regardless of its expression. This will cause differences from the amino acid sequence of the previous annotation. Functional classification -Transport/binding proteins - Cations 192222000441 HMMPfam hit to PF01814, Hemerythrin HHE cation binding domain, score 2.9 192222000442 HMMPfam hit to PF01814, Hemerythrin HHE cation binding domain, score 0.007 192222000443 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 192222000444 HMMPfam hit to PF02589, Uncharacterized ACR, YkgG family COG1556, score 1.2e-29 192222000445 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 192222000446 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 192222000447 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 192222000448 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 192222000449 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.00065 192222000450 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222000451 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.0015 192222000452 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222000453 PS00018 EF-hand calcium-binding domain 192222000454 Cysteine-rich domain; Region: CCG; pfam02754 192222000455 Cysteine-rich domain; Region: CCG; pfam02754 192222000456 HMMPfam hit to PF02754, Cysteine-rich domain, score 7.2e-19 192222000457 HMMPfam hit to PF02754, Cysteine-rich domain, score 5.1e-12 192222000458 glycolate transporter; Provisional; Region: PRK09695 192222000459 L-lactate permease; Region: Lactate_perm; cl00701 192222000460 HMMPfam hit to PF02652, L-lactate permease, score 1.2e-268 192222000461 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000462 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 192222000463 HMMPfam hit to PF03499, Cytolethal distending toxin C, score 3.6e-81 192222000464 CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081 192222000465 putative catalytic site [active] 192222000466 CdtC interface [polypeptide binding]; other site 192222000467 heterotrimer interface [polypeptide binding]; other site 192222000468 CdtA interface [polypeptide binding]; other site 192222000469 putative metal binding site [ion binding]; other site 192222000470 putative phosphate binding site [ion binding]; other site 192222000471 HMMPfam hit to PF03372,Endonuclease/Exonuclease/phosphatase fa, score 7.8e-23 192222000472 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 192222000473 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 192222000474 putative sugar binding sites [chemical binding]; other site 192222000475 Q-X-W motif; other site 192222000476 HMMPfam hit to PF03498, Cytolethal distending toxin A, score 1.6e-33 192222000477 1 probable transmembrane helix predicted for Cj0079c by TMHMM2.0 at aa 5-22 192222000478 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000479 2 probable transmembrane helices predicted for Cj0080 by TMHMM2.0 at aa 10-29 and 42-64 192222000480 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 192222000481 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 192222000482 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 192222000483 HMMPfam hit to PF01654, Bacterial Cytochrome Ubiquinol Oxidase, score 3.3e-191 192222000484 9 probable transmembrane helices predicted for Cj0081 by TMHMM2.0 at aa 15-37, 56-78, 98-120, 127-149,186-208, 221-240, 391-413, 426-448 and 477-499 192222000485 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 192222000486 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 192222000487 HMMPfam hit to PF02322, Cytochrome oxidase subunit II, score 3.5e-13 192222000488 9 probable transmembrane helices predicted for Cj0082 by TMHMM2.0 at aa 10-31, 59-81, 86-108, 129-151,175-197, 210-229, 249-271, 284-306 and 332-354 192222000489 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 192222000490 aspartate racemase; Region: asp_race; TIGR00035 192222000491 HMMPfam hit to PF01177, Asp/Glu/Hydantoin racemase,score 4.8e-67 192222000492 PS00924 Aspartate and glutamate racemases signature 2 192222000493 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 192222000494 ligand binding site [chemical binding]; other site 192222000495 active site 192222000496 UGI interface [polypeptide binding]; other site 192222000497 catalytic site [active] 192222000498 HMMPfam hit to PF03167, Uracil DNA glycosylase superfamily, score 1.6e-73 192222000499 PS00130 Uracil-DNA glycosylase signature 192222000500 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 192222000501 Aspartase; Region: Aspartase; cd01357 192222000502 active sites [active] 192222000503 tetramer interface [polypeptide binding]; other site 192222000504 HMMPfam hit to PF00206, Lyase, score 1.2e-151 192222000505 PS00163 Fumarate lyases signature 192222000506 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 192222000507 12 probable transmembrane helices predicted for Cj0088 by TMHMM2.0 at aa 3-20, 25-42, 49-71, 91-113,134-156, 171-193, 230-249, 259-281, 301-323, 338-360,380-402 and 422-444 192222000508 HMMPfam hit to PF03605, Anaerobic c4-dicarboxylate membrane transpo, score 3.9e-245 192222000509 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 192222000511 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000512 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 1.4 192222000513 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.12 192222000514 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 192222000515 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 192222000516 putative dimer interface [polypeptide binding]; other site 192222000517 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000518 TolB amino-terminal domain; Region: TolB_N; cl00639 192222000519 1 probable transmembrane helix predicted for Cj0091 by TMHMM2.0 at aa 7-26 192222000520 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000521 PS00017 ATP/GTP-binding site motif A (P-loop) 192222000522 TolB amino-terminal domain; Region: TolB_N; cl00639 192222000523 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 192222000524 HMMPfam hit to PF00829, Ribosomal prokaryotic L21 protein, score 3.6e-48 192222000525 PS01169 Ribosomal protein L21 signature 192222000526 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 192222000527 HMMPfam hit to PF01016, Ribosomal L27 protein,score 3.7e-54 192222000528 PS00831 Ribosomal protein L27 signature 192222000529 GTPase CgtA; Reviewed; Region: obgE; PRK12299 192222000530 GTP1/OBG; Region: GTP1_OBG; pfam01018 192222000531 Obg GTPase; Region: Obg; cd01898 192222000532 G1 box; other site 192222000533 GTP/Mg2+ binding site [chemical binding]; other site 192222000534 Switch I region; other site 192222000535 G2 box; other site 192222000536 G3 box; other site 192222000537 Switch II region; other site 192222000538 G4 box; other site 192222000539 G5 box; other site 192222000540 HMMPfam hit to PF01018, GTP1/OBG, score 2.7e-75 192222000541 HMMPfam hit to PF01926, GTPase of unknown function,score 2.7e-33 192222000542 PS00017 ATP/GTP-binding site motif A (P-loop) 192222000543 PS00905 GTP1/OBG family signature 192222000544 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 192222000545 nucleotide binding site [chemical binding]; other site 192222000546 homotetrameric interface [polypeptide binding]; other site 192222000547 putative phosphate binding site [ion binding]; other site 192222000548 putative allosteric binding site; other site 192222000549 HMMPfam hit to PF00696, Amino acid kinase family,score 1e-41 192222000550 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 192222000551 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 192222000552 putative active site [active] 192222000553 substrate binding site [chemical binding]; other site 192222000554 putative cosubstrate binding site; other site 192222000555 catalytic site [active] 192222000556 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 192222000557 substrate binding site [chemical binding]; other site 192222000558 HMMPfam hit to PF00551, Formyl transferase, score 4.4e-36 192222000559 HMMPfam hit to PF02911, Formyl transferase,C-terminal domain, score 8e-24 192222000560 biotin--protein ligase; Provisional; Region: PRK08477 192222000561 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 192222000562 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 2e-13 192222000563 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 192222000564 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 192222000565 P-loop; other site 192222000566 Magnesium ion binding site [ion binding]; other site 192222000567 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 192222000568 Magnesium ion binding site [ion binding]; other site 192222000569 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 9.4e-53 192222000570 ParB-like nuclease domain; Region: ParBc; cl02129 192222000571 ParB-like partition proteins; Region: parB_part; TIGR00180 192222000572 HMMPfam hit to PF02195, ParB-like nuclease domain,score 2.7e-34 192222000573 Plant ATP synthase F0; Region: YMF19; cl07975 192222000574 HMMPfam hit to PF00430, ATP synthase B/B' CF(0),score 1.5e-06 192222000575 1 probable transmembrane helix predicted for Cj0102 by TMHMM2.0 at aa 10-29 192222000576 Plant ATP synthase F0; Region: YMF19; cl07975 192222000577 2 probable transmembrane helices predicted for Cj0103 by TMHMM2.0 at aa 5-22 and 27-49 192222000578 HMMPfam hit to PF00430, ATP synthase B/B' CF(0),score 0.00034 192222000579 Plant ATP synthase F0; Region: YMF19; cl07975 192222000580 HMMPfam hit to PF00213, ATP synthase delta (OSCP) subunit, score 1.1e-07 192222000581 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 192222000582 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 192222000583 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 192222000584 beta subunit interaction interface [polypeptide binding]; other site 192222000585 Walker A motif; other site 192222000586 ATP binding site [chemical binding]; other site 192222000587 Walker B motif; other site 192222000588 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 192222000589 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 7.9e-19 192222000590 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 3.4e-115 192222000591 PS00017 ATP/GTP-binding site motif A (P-loop) 192222000592 PS00152 ATP synthase alpha and beta subunits signature 192222000593 HMMPfam hit to PF00306, ATP synthase alpha/beta chain, C termin, score 2.5e-36 192222000594 ATP synthase; Region: ATP-synt; cl00365 192222000595 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 192222000596 HMMPfam hit to PF00231, ATP synthase, score 2.8e-83 192222000597 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 192222000598 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 192222000599 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 192222000600 alpha subunit interaction interface [polypeptide binding]; other site 192222000601 Walker A motif; other site 192222000602 ATP binding site [chemical binding]; other site 192222000603 Walker B motif; other site 192222000604 inhibitor binding site; inhibition site 192222000605 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 192222000606 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 4.3e-21 192222000607 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 1e-94 192222000608 PS00017 ATP/GTP-binding site motif A (P-loop) 192222000609 PS00152 ATP synthase alpha and beta subunits signature 192222000610 HMMPfam hit to PF00306, ATP synthase alpha/beta chain, C termin, score 7.2e-55 192222000611 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 192222000612 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 192222000613 HMMPfam hit to PF02823, ATP synthase, Delta/Epsilon chain, beta, score 2.6e-21 192222000614 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 192222000615 3 probable transmembrane helices predicted for Cj0109 by TMHMM2.0 at aa 15-37, 96-118 and 138-160 192222000616 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 1e-24 192222000617 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 192222000618 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 7.2e-16 192222000619 1 probable transmembrane helix predicted for Cj0110 by TMHMM2.0 at aa 10-32 192222000620 Gram-negative bacterial tonB protein; Region: TonB; cl10048 192222000621 1 probable transmembrane helix predicted for Cj0111 by TMHMM2.0 at aa 9-31 192222000622 translocation protein TolB; Provisional; Region: tolB; PRK04043 192222000623 HMMPfam hit to PF04052, TolB amino-terminal domain,score 4e-51 192222000624 PS00284 Serpins signature 192222000625 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 192222000626 ligand binding site [chemical binding]; other site 192222000627 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000628 HMMPfam hit to PF00691, OmpA family, score 2.1e-27 192222000629 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 192222000630 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.012 192222000631 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 192222000632 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000633 Acyl transferase domain; Region: Acyl_transf_1; cl08282 192222000634 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 192222000635 HMMPfam hit to PF00698, Acyl transferase domain,score 6.7e-07 192222000636 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 192222000637 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164 192222000638 HMMPfam hit to PF01048, Phosphorylase family, score 1.9e-56 192222000639 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 192222000640 Ligand Binding Site [chemical binding]; other site 192222000641 HMMPfam hit to PF01171, PP-loop family, score 4e-14 192222000642 Isochorismatase family; Region: Isochorismatase; pfam00857 192222000643 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 192222000644 catalytic triad [active] 192222000645 conserved cis-peptide bond; other site 192222000646 Recombination protein O N terminal; Region: RecO_N; cl15812 192222000647 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 192222000648 HMMPfam hit to PF02130, Uncharacterized protein family UPF0054, score 6.5e-36 192222000649 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 192222000650 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 192222000651 FMN binding site [chemical binding]; other site 192222000652 active site 192222000653 catalytic residues [active] 192222000654 substrate binding site [chemical binding]; other site 192222000655 HMMPfam hit to PF01207, Dihydrouridine synthase (Dus), score 3.1e-75 192222000656 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 192222000657 HMMPfam hit to PF01258, Prokaryotic dksA/traR C4-type zinc finge, score 6.8e-09 192222000658 PS01102 Prokaryotic dksA/traR C4-type zinc finger 192222000659 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 192222000660 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 192222000661 HMMPfam hit to PF02590, Uncharacterized ACR,COG1576, score 9.2e-69 192222000662 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 192222000663 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 192222000664 PS00190 Cytochrome c family heme-binding site signature 192222000665 Putative fructose-1,6-bisphosphatase or related enzymes of inositol monophosphatase family. These are Mg++ dependent phosphatases. Members in this family may have fructose-1,6-bisphosphatase and/or inositol-monophosphatase activity. Fructose-1; Region: Arch_FBPase_2; cd01642 192222000666 putative active site [active] 192222000667 HMMPfam hit to PF00459, Inositol monophosphatase family, score 1.2e-06 192222000668 1 probable transmembrane helix predicted for Cj0128c by TMHMM2.0 at aa 172-194 192222000669 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 192222000670 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 192222000671 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 192222000672 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 192222000673 Surface antigen; Region: Bac_surface_Ag; cl03097 192222000674 HMMPfam hit to PF01103, Surface antigen, score 3e-78 192222000675 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 5.9e-08 192222000676 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 3e-07 192222000677 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 1.7e-07 192222000678 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 1.3e-07 192222000679 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 3.7e-07 192222000680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222000681 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 192222000682 HMMPfam hit to PF02153, Prephenate dehydrogenase,score 1.2e-83 192222000683 Peptidase family M23; Region: Peptidase_M23; pfam01551 192222000684 1 probable transmembrane helix predicted for Cj0131 by TMHMM2.0 at aa 9-31 192222000685 HMMPfam hit to PF01551, Peptidase family M23, score 5.2e-27 192222000686 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 192222000687 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 192222000688 HMMPfam hit to PF03331, UDP-3-O-acyl N-acetylglycosamine deacetylase, score 5.5e-135 192222000689 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 192222000690 HMMPfam hit to PF00814, Glycoprotease family, score 1e-18 192222000691 homoserine kinase; Provisional; Region: PRK01212 192222000692 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 192222000693 HMMPfam hit to PF00288, GHMP kinases ATP-binding protei, score 6e-28 192222000694 PS00627 GHMP kinases ATP-binding domain 192222000695 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000696 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 192222000697 HMMPfam hit to PF04296, Protein of unknown function (DUF448), score 5.8e-31 192222000698 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 192222000699 translation initiation factor IF-2; Region: IF-2; TIGR00487 192222000700 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 192222000701 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 192222000702 G1 box; other site 192222000703 putative GEF interaction site [polypeptide binding]; other site 192222000704 GTP/Mg2+ binding site [chemical binding]; other site 192222000705 Switch I region; other site 192222000706 G2 box; other site 192222000707 G3 box; other site 192222000708 Switch II region; other site 192222000709 G4 box; other site 192222000710 G5 box; other site 192222000711 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 192222000712 Translation-initiation factor 2; Region: IF-2; pfam11987 192222000713 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 192222000714 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-ter, score 8.4e-15 192222000715 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-ter, score 1.2e-20 192222000716 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 2.5e-54 192222000717 HMMPfam hit to PF01926, GTPase of unknown function,score 8.6e-10 192222000718 PS00017 ATP/GTP-binding site motif A (P-loop) 192222000719 HMMPfam hit to PF03144, Elongation factor Tu domain, score 1.3e-08 192222000720 HMMPfam hit to PF03144, Elongation factor Tu domain, score 1.4e-08 192222000721 PS01176 Initiation factor 2 signature 192222000722 Ribosome-binding factor A; Region: RBFA; cl00542 192222000723 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 192222000724 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 192222000725 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 192222000726 Sm1 motif; other site 192222000727 D1 - D2 interaction site; other site 192222000728 D3 - B interaction site; other site 192222000729 Hfq - Hfq interaction site; other site 192222000730 RNA binding pocket [nucleotide binding]; other site 192222000731 Sm2 motif; other site 192222000732 HMMPfam hit to PF02576, Uncharacterised BCR, YhbC family COG0779, score 1e-62 192222000733 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 192222000734 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222000735 PS00017 ATP/GTP-binding site motif A (P-loop) 192222000736 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 192222000737 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 192222000738 dimer interface [polypeptide binding]; other site 192222000739 putative PBP binding regions; other site 192222000740 ABC-ATPase subunit interface; other site 192222000741 HMMPfam hit to PF00950, ABC 3 transport family,score 7.6e-82 192222000742 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000743 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000744 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 192222000745 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 192222000746 HMMPfam hit to PF00005, ABC transporter, score 7.4e-49 192222000747 PS00211 ABC transporters family signature 192222000748 PS00017 ATP/GTP-binding site motif A (P-loop) 192222000749 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 192222000750 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 192222000751 putative metal binding residues [ion binding]; other site 192222000752 HMMPfam hit to PF01297, Periplasmic solute binding protein family, score 6.1e-62 192222000753 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 192222000754 Cache domain; Region: Cache_1; pfam02743 192222000755 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 192222000756 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 192222000757 dimer interface [polypeptide binding]; other site 192222000758 putative CheW interface [polypeptide binding]; other site 192222000759 2 probable transmembrane helices predicted for Cj0144 by TMHMM2.0 at aa 10-32 and 287-309 192222000760 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 6.4e-21 192222000761 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 192222000762 HMMPfam hit to PF05787, Bacterial protein of unknown function (DUF83, score 0 192222000763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222000764 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 192222000765 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 192222000766 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreducta, score 6e-58 192222000767 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site 192222000768 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 192222000769 catalytic residues [active] 192222000770 HMMPfam hit to PF00085, Thioredoxin, score 6.9e-39 192222000771 PS00194 Thioredoxin family active site 192222000772 Restriction endonuclease; Region: Mrr_cat; cl00516 192222000773 HMMPfam hit to PF02021, Uncharacterised protein family UPF0102, score 6e-16 192222000774 homoserine dehydrogenase; Provisional; Region: PRK06349 192222000775 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 192222000776 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 192222000777 HMMPfam hit to PF01842, ACT domain, score 2e-10 192222000778 HMMPfam hit to PF00742, Homoserine dehydrogenase,score 2.7e-73 192222000779 PS01042 Homoserine dehydrogenase signature 192222000780 HMMPfam hit to PF03447, Homoserine dehydrogenase,NAD binding d, score 3.1e-13 192222000781 aminotransferase; Validated; Region: PRK08175 192222000782 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 192222000783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222000784 homodimer interface [polypeptide binding]; other site 192222000785 catalytic residue [active] 192222000786 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.3e-29 192222000787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 192222000788 1 probable transmembrane helix predicted for Cj0152c by TMHMM2.0 at aa 94-116 192222000789 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 192222000790 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 192222000791 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 192222000792 HMMPfam hit to PF00588, SpoU rRNA Methylase family,score 7e-28 192222000793 Predicted methyltransferases [General function prediction only]; Region: COG0313 192222000794 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 192222000795 HMMPfam hit to PF00590, Tetrapyrrole (Corrin/Porphyrin) Methylas, score 9.6e-20 192222000796 PS01296 Uncharacterized protein family UPF0011 signature 192222000797 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 192222000798 HMMPfam hit to PF01197, Ribosomal protein L31,score 4.2e-40 192222000799 PS01143 Ribosomal protein L31 signature 192222000800 PS00190 Cytochrome c family heme-binding site signature 192222000801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 192222000802 HMMPfam hit to PF04452, Protein of unknown function (DUF558), score 1.2e-28 192222000803 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000804 Cytochrome c; Region: Cytochrom_C; cl11414 192222000805 HMMPfam hit to PF00034, Cytochrome c, score 0.041 192222000806 PS00190 Cytochrome c family heme-binding site signature 192222000807 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000808 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 192222000809 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 192222000810 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 192222000811 FeS/SAM binding site; other site 192222000812 HMMPfam hit to PF04055, Radical SAM superfamily,score 3.1e-08 192222000813 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 192222000814 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 192222000815 FeS/SAM binding site; other site 192222000816 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 192222000817 HMMPfam hit to PF06463, Molybdenum Cofactor Synthesis C, score 1.5e-47 192222000818 HMMPfam hit to PF04055, Radical SAM superfamily,score 5.8e-38 192222000819 PS01305 moaA / nifB / pqqE family signature 192222000820 1 probable transmembrane helix predicted for Cj0162c by TMHMM2.0 at aa 5-24 192222000821 UbiA prenyltransferase family; Region: UbiA; cl00337 192222000822 HMMPfam hit to PF01040, UbiA prenyltransferase family, score 3.1e-52 192222000823 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000824 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 192222000825 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222000826 PS00017 ATP/GTP-binding site motif A (P-loop) 192222000827 HMMPfam hit to PF01715, IPP transferase, score 5.9e-46 192222000828 Predicted membrane protein [Function unknown]; Region: COG1971 192222000829 Domain of unknown function DUF; Region: DUF204; pfam02659 192222000830 HMMPfam hit to PF02659, Domain of unknown function DUF, score 1.5e-17 192222000831 HMMPfam hit to PF02659, Domain of unknown function DUF, score 4.5e-15 192222000832 1 probable transmembrane helix predicted for Cj0168c by TMHMM2.0 at aa 4-21 192222000833 superoxide dismutase; Provisional; Region: PRK10543 192222000834 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 192222000835 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 192222000836 HMMPfam hit to PF00081, Iron/manganese superoxide dismutases, alpha-, score 2.8e-30 192222000837 HMMPfam hit to PF02777, Iron/manganese superoxide dismutases, C-term, score 3.3e-45 192222000838 PS00088 Manganese and iron superoxide dismutases signature 192222000839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222000840 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 192222000841 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 192222000842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222000843 NAD(P) binding pocket [chemical binding]; other site 192222000844 HMMPfam hit to PF03435, Saccharopine dehydrogenase,score 2e-236 192222000845 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 192222000846 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 192222000847 Walker A/P-loop; other site 192222000848 ATP binding site [chemical binding]; other site 192222000849 Q-loop/lid; other site 192222000850 ABC transporter signature motif; other site 192222000851 Walker B; other site 192222000852 D-loop; other site 192222000853 H-loop/switch region; other site 192222000854 HMMPfam hit to PF00005, ABC transporter, score 2.3e-45 192222000855 PS00211 ABC transporters family signature 192222000856 PS00017 ATP/GTP-binding site motif A (P-loop) 192222000857 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 192222000858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 192222000859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 192222000860 dimer interface [polypeptide binding]; other site 192222000861 conserved gate region; other site 192222000862 putative PBP binding loops; other site 192222000863 ABC-ATPase subunit interface; other site 192222000864 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 5.4e-07 192222000865 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 192222000866 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 192222000867 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 4.7e-14 192222000868 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000869 Protein of unknown function, DUF399; Region: DUF399; cl01139 192222000870 HMMPfam hit to PF04187, Protein of unknown function, DUF399, score 5e-164 192222000871 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000872 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 192222000873 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 192222000874 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 9.2e-13 192222000875 HMMPfam hit to PF00593, TonB dependent receptor,score 1.5e-22 192222000876 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 192222000877 3 probable transmembrane helices predicted for Cj0179 by TMHMM2.0 at aa 57-74, 155-177 and 197-219 192222000878 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 8.6e-47 192222000879 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 192222000880 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 8.4e-22 192222000881 1 probable transmembrane helix predicted for Cj0180 by TMHMM2.0 at aa 13-35 192222000882 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 192222000883 Gram-negative bacterial tonB protein; Region: TonB; cl10048 192222000884 1 probable transmembrane helix predicted for Cj0181 by TMHMM2.0 at aa 7-29 192222000885 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 192222000886 6 probable transmembrane helices predicted for Cj0182 by TMHMM2.0 at aa 13-35, 127-149, 197-219, 244-266,316-330 and 334-356 192222000887 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 192222000888 Domain of unknown function DUF21; Region: DUF21; pfam01595 192222000889 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 192222000890 Transporter associated domain; Region: CorC_HlyC; cl08393 192222000891 4 probable transmembrane helices predicted for Cj0183 by TMHMM2.0 at aa 20-42, 75-97, 117-139 and 162-184 192222000892 HMMPfam hit to PF01595, Domain of unknown function DUF21, score 3.2e-83 192222000893 HMMPfam hit to PF00571, CBS domain, score 2.5e-08 192222000894 HMMPfam hit to PF00571, CBS domain, score 6.5e-12 192222000895 HMMPfam hit to PF03471, Transporter associated domain, score 1.3e-22 192222000896 Predicted kinase [General function prediction only]; Region: COG4639 192222000897 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 192222000898 active site 192222000899 metal binding site [ion binding]; metal-binding site 192222000900 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 6.6e-12 192222000901 PhnA protein; Region: PhnA; pfam03831 192222000902 HMMPfam hit to PF03831, PhnA protein, score 3.1e-30 192222000903 Integral membrane protein TerC family; Region: TerC; cl10468 192222000904 HMMPfam hit to PF03741, Integral membrane protein TerC family, score 2.9e-96 192222000905 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 192222000906 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; Region: PurN; TIGR00639 192222000907 active site 192222000908 substrate binding site [chemical binding]; other site 192222000909 cosubstrate binding site; other site 192222000910 catalytic site [active] 192222000911 HMMPfam hit to PF00551, Formyl transferase, score 2.9e-50 192222000912 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 192222000913 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 192222000914 putative substrate binding site [chemical binding]; other site 192222000915 putative ATP binding site [chemical binding]; other site 192222000916 HMMPfam hit to PF01256, Carbohydrate kinase, score 4.5e-26 192222000917 PS01050 Uncharacterized protein family UPF0031 signature 2 192222000918 HMMPfam hit to PF03853, YjeF-related protein N-terminus, score 2.1e-54 192222000919 Uncharacterized conserved protein [Function unknown]; Region: COG1432 192222000920 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 192222000921 putative metal binding site [ion binding]; other site 192222000922 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 192222000923 HMMPfam hit to PF01936, Protein of unknown function DUF88, score 1.1e-05 192222000924 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 192222000925 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 192222000926 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222000927 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 192222000928 HMMPfam hit to PF01078, Magnesium chelatase,subunit ChlI, score 9.4e-40 192222000929 PS00017 ATP/GTP-binding site motif A (P-loop) 192222000930 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 192222000931 active site 192222000932 catalytic residues [active] 192222000933 metal binding site [ion binding]; metal-binding site 192222000934 HMMPfam hit to PF01327, Polypeptide deformylase,score 4.7e-50 192222000935 Clp protease; Region: CLP_protease; pfam00574 192222000936 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 192222000937 oligomer interface [polypeptide binding]; other site 192222000938 active site residues [active] 192222000939 HMMPfam hit to PF00574, Clp protease, score 4e-136 192222000940 PS00382 Endopeptidase Clp histidine active site 192222000941 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000942 PS00381 Endopeptidase Clp serine active site 192222000943 trigger factor; Provisional; Region: tig; PRK01490 192222000944 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 192222000945 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 192222000946 HMMPfam hit to PF05698, Bacterial trigger factor protein (TF) C-ter, score 2e-42 192222000947 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomera, score 1.2e-27 192222000948 HMMPfam hit to PF05697, Bacterial trigger factor protein (TF), score 1.3e-44 192222000949 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 192222000950 homodecamer interface [polypeptide binding]; other site 192222000951 GTP cyclohydrolase I; Provisional; Region: PLN03044 192222000952 active site 192222000953 putative catalytic site residues [active] 192222000954 zinc binding site [ion binding]; other site 192222000955 GTP-CH-I/GFRP interaction surface; other site 192222000956 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 9.9e-56 192222000957 PS00859 GTP cyclohydrolase I signature 1 192222000958 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08472 192222000959 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 192222000960 Walker A motif/ATP binding site; other site 192222000961 Walker B motif; other site 192222000962 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleotid, score 4.1e-104 192222000963 PS00017 ATP/GTP-binding site motif A (P-loop) 192222000964 PS00152 ATP synthase alpha and beta subunits signature 192222000965 amidophosphoribosyltransferase; Provisional; Region: PRK08525 192222000966 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 192222000967 active site 192222000968 tetramer interface [polypeptide binding]; other site 192222000969 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 192222000970 active site 192222000971 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 2.2e-12 192222000972 PS00103 Purine/pyrimidine phosphoribosyl transferases signature 192222000973 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 2.8e-27 192222000974 dihydrodipicolinate reductase; Provisional; Region: PRK00048 192222000975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222000976 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 192222000977 HMMPfam hit to PF05173, Dihydrodipicolinate reductase, C-terminus, score 1e-75 192222000978 PS01298 Dihydrodipicolinate reductase signature 192222000979 HMMPfam hit to PF01113, Dihydrodipicolinate reductase, N-terminus, score 1.7e-38 192222000980 recombination factor protein RarA; Reviewed; Region: PRK13342 192222000981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 192222000982 Walker A motif; other site 192222000983 ATP binding site [chemical binding]; other site 192222000984 Walker B motif; other site 192222000985 arginine finger; other site 192222000986 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 192222000987 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 6.5e-07 192222000988 PS00017 ATP/GTP-binding site motif A (P-loop) 192222000989 1 probable transmembrane helix predicted for Cj0199c by TMHMM2.0 at aa 5-24 192222000990 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 192222000991 PS00216 Sugar transport proteins signature 1 192222000992 1 probable transmembrane helix predicted for Cj0201c by TMHMM2.0 at aa 7-26 192222000993 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 192222000994 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 192222000995 12 probable transmembrane helices predicted for Cj0203 by TMHMM2.0 at aa 4-21, 28-45, 50-72, 84-106,126-148, 161-180, 195-217, 249-282, 302-321, 341-363,373-395 and 428-447 192222000996 HMMPfam hit to PF03600, Citrate transporter, score 7.1e-122 192222000997 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000998 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222000999 OPT oligopeptide transporter protein; Region: OPT; cl14607 192222001000 oligopeptide transporters, OPT superfamily; Region: OPT_sfam; TIGR00728 192222001001 HMMPfam hit to PF03169, OPT oligopeptide transporter protein, score 1.1e-95 192222001002 16 probable transmembrane helices predicted for Cj0204 by TMHMM2.0 at aa 13-35, 39-61, 73-95, 99-121,162-184, 188-210, 212-234, 314-333, 345-367, 377-399,406-428, 450-472, 508-530, 545-567, 598-620 and 635-657 192222001003 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001004 Bacitracin resistance protein BacA; Region: BacA; cl00858 192222001005 HMMPfam hit to PF02673, Bacitracin resistance protein BacA, score 3.2e-133 192222001006 7 probable transmembrane helices predicted for Cj0205 by TMHMM2.0 at aa 7-29, 44-66, 71-90, 100-119,172-194, 209-231 and 236-258 192222001007 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 192222001008 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 192222001009 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 192222001010 active site 192222001011 dimer interface [polypeptide binding]; other site 192222001012 motif 1; other site 192222001013 motif 2; other site 192222001014 motif 3; other site 192222001015 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 192222001016 anticodon binding site; other site 192222001017 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 1e-48 192222001018 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 192222001019 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 192222001020 HMMPfam hit to PF03129, Anticodon binding domain,score 2.9e-26 192222001021 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 192222001022 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 192222001023 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 192222001024 HMMPfam hit to PF05198, Translation initiation factor IF-3, N-termin, score 2.5e-47 192222001025 PS00938 Initiation factor 3 signature 192222001026 HMMPfam hit to PF00707, Translation initiation factor IF-3, C-termin, score 3.5e-31 192222001027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222001028 HMMPfam hit to PF02086, D12 class N6 adenine-specific DNA met, score 2.6e-08 192222001029 PS00092 N-6 Adenine-specific DNA methylases signature 192222001030 Original (2000) note: Cj0223, probable pseudogene,len: 3423 bp similar to several members of the IgA protease/haemaglutinin/sepA family e.g. IGA2_HAEIN immunoglobulin A1 protease precursor (EC 3.4.21.72),TR:Q54151 (EMBL:U35656) Shigella flexneri she hemagglutinin, and TR:Q54165 (EMBL:Z48219) Shigella flexneri sepA gene precursor. No apparent Hp match; Updated (2006) note: No specific characterisation with acceptable identity score (aligning whole sequence),has been carried out yet. Thus, added to product function. Coding sequence has been updated to reflect the complete amino acid sequence for the encoded protein regardless of its expression. This will cause differences from the amino acid sequence of the previous annotation. Functional classification - Pathogenicity; PMID:10225873, PMID:10531204 192222001031 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 192222001032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222001033 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 192222001034 HMMPfam hit to PF01118, Semialdehyde dehydrogenase,NAD bindi, score 1.1e-35 192222001035 HMMPfam hit to PF02774, Semialdehyde dehydrogenase,dimerisat, score 2.1e-41 192222001036 putative acetyltransferase; Provisional; Region: PRK03624 192222001037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 192222001038 Coenzyme A binding pocket [chemical binding]; other site 192222001039 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 4.1e-15 192222001040 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 192222001041 feedback inhibition sensing region; other site 192222001042 homohexameric interface [polypeptide binding]; other site 192222001043 nucleotide binding site [chemical binding]; other site 192222001044 N-acetyl-L-glutamate binding site [chemical binding]; other site 192222001045 HMMPfam hit to PF00696, Amino acid kinase family,score 3.1e-51 192222001046 acetylornithine aminotransferase; Provisional; Region: PRK02627 192222001047 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 192222001048 inhibitor-cofactor binding pocket; inhibition site 192222001049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222001050 catalytic residue [active] 192222001051 HMMPfam hit to PF00202, Aminotransferase class-III,score 4.3e-133 192222001052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222001053 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 192222001054 HMMPfam hit to PF01135,Protein-L-isoaspartate(D-aspartate) O-methyl, score 1e-51 192222001055 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 192222001056 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 192222001057 trimer interface [polypeptide binding]; other site 192222001058 putative metal binding site [ion binding]; other site 192222001059 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 7.6 192222001060 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.1e+02 192222001061 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.0059 192222001062 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 21 192222001063 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 8.1 192222001064 putative nicotinate phosphoribosyltransferase; Region: NAPRTase_put; TIGR01513 192222001065 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 192222001066 active site 192222001067 HMMPfam hit to PF04095, Nicotinate phosphoribosyltransferase (NAPRTa, score 3.6e-11 192222001068 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001069 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 192222001070 dimer interface [polypeptide binding]; other site 192222001071 putative radical transfer pathway; other site 192222001072 diiron center [ion binding]; other site 192222001073 tyrosyl radical; other site 192222001074 HMMPfam hit to PF00268, Ribonucleotide reductase,small chain, score 1.8e-30 192222001075 RDD family; Region: RDD; cl00746 192222001076 HMMPfam hit to PF06271, RDD family, score 1e-13 192222001077 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 192222001078 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 192222001079 active site 192222001080 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 2.3e-22 192222001081 PS00103 Purine/pyrimidine phosphoribosyl transferases signature 192222001082 ribosome recycling factor; Reviewed; Region: frr; PRK00083 192222001083 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 192222001084 hinge region; other site 192222001085 HMMPfam hit to PF01765, Ribosome recycling factor,score 4.9e-88 192222001086 Preprotein translocase SecG subunit; Region: SecG; cl09123 192222001087 HMMPfam hit to PF03840, Preprotein translocase SecG subunit, score 2.8e-24 192222001088 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 192222001089 HMMPfam hit to PF01027, Uncharacterised protein family UPF0005, score 2.5e-36 192222001090 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 192222001091 active site clefts [active] 192222001092 zinc binding site [ion binding]; other site 192222001093 dimer interface [polypeptide binding]; other site 192222001094 HMMPfam hit to PF00484, Carbonic anhydrase, score 1.9e-45 192222001095 PS00704 Prokaryotic-type carbonic anhydrases signature 1 192222001096 PS00705 Prokaryotic-type carbonic anhydrases signature 2 192222001097 Mechanosensitive ion channel; Region: MS_channel; pfam00924 192222001098 6 probable transmembrane helices predicted for Cj0238 by TMHMM2.0 at aa 238-260, 265-279, 300-322,332-354, 366-388 and 392-411 192222001099 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 2e-68 192222001100 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 192222001101 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 192222001102 trimerization site [polypeptide binding]; other site 192222001103 active site 192222001104 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 192222001105 NifU-like domain; Region: NifU; cl00484 192222001106 HMMPfam hit to PF01106, NifU-like domain, score 2.1e-27 192222001107 HMMPfam hit to PF04324, BFD-like [2Fe-2S] binding domain, score 5.7e-15 192222001108 HMMPfam hit to PF01592, NifU-like N terminal domain, score 2.9e-64 192222001109 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 192222001110 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 192222001111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 192222001112 catalytic residue [active] 192222001113 HMMPfam hit to PF00266, Aminotransferase class-V,score 3.2e-105 192222001114 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001115 PS00132 Zinc carboxypeptidases, zinc-binding region 1 signature 192222001116 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site 192222001117 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 192222001118 HMMPfam hit to PF01814, Hemerythrin HHE cation binding domain, score 0.0029 192222001119 HMMPfam hit to PF01814, Hemerythrin HHE cation binding domain, score 0.0079 192222001120 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 192222001121 HMMPfam hit to PF01632, Ribosomal protein L35,score 4.9e-18 192222001122 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 192222001123 23S rRNA binding site [nucleotide binding]; other site 192222001124 L21 binding site [polypeptide binding]; other site 192222001125 L13 binding site [polypeptide binding]; other site 192222001126 HMMPfam hit to PF00453, Ribosomal protein L20,score 4.5e-51 192222001127 PS00937 Ribosomal protein L20 signature 192222001128 FIST C domain; Region: FIST_C; pfam10442 192222001129 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 192222001130 dimer interface [polypeptide binding]; other site 192222001131 putative CheW interface [polypeptide binding]; other site 192222001132 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 4.2e-09 192222001133 FIST N domain; Region: FIST; cl10701 192222001134 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 192222001135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 192222001136 metabolite-proton symporter; Region: 2A0106; TIGR00883 192222001137 putative substrate translocation pore; other site 192222001138 HMMPfam hit to PF00083, Sugar (and other) transporter, score 4.5e-24 192222001139 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.4e-20 192222001140 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001141 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 192222001142 trimer interface [polypeptide binding]; other site 192222001143 dimer interface [polypeptide binding]; other site 192222001144 putative active site [active] 192222001145 HMMPfam hit to PF01967, MoaC family, score 6.3e-78 192222001146 Protein of unknown function (DUF493); Region: DUF493; cl01102 192222001147 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 192222001148 putative catalytic site [active] 192222001149 putative metal binding site [ion binding]; other site 192222001150 putative phosphate binding site [ion binding]; other site 192222001151 HMMPfam hit to PF03372,Endonuclease/Exonuclease/phosphatase fa, score 5.2e-47 192222001152 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 192222001153 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 192222001154 Sulfatase; Region: Sulfatase; cl10460 192222001155 5 probable transmembrane helices predicted for Cj0256 by TMHMM2.0 at aa 5-27, 37-59, 66-88, 108-127 and 148-170 192222001156 HMMPfam hit to PF00884, Sulfatase, score 1.3e-98 192222001157 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 192222001158 HMMPfam hit to PF01219, Prokaryotic diacylglycerol kinase, score 3.3e-32 192222001159 3 probable transmembrane helices predicted for Cj0257 by TMHMM2.0 at aa 26-45, 52-74 and 94-116 192222001160 PS01069 Prokaryotic diacylglycerol kinase signature 192222001161 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 192222001162 active site 192222001163 substrate binding pocket [chemical binding]; other site 192222001164 dimer interface [polypeptide binding]; other site 192222001165 HMMPfam hit to PF01979, Amidohydrolase family,score 1.7e-60 192222001166 PS00482 Dihydroorotase signature 1 192222001167 PS00483 Dihydroorotase signature 2 192222001168 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 192222001169 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 192222001170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 192222001171 S-adenosylmethionine binding site [chemical binding]; other site 192222001172 Cache domain; Region: Cache_1; pfam02743 192222001173 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 192222001174 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 192222001175 dimer interface [polypeptide binding]; other site 192222001176 putative CheW interface [polypeptide binding]; other site 192222001177 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 6.4e-21 192222001178 HMMPfam hit to PF00672, HAMP domain, score 0.0012 192222001179 HMMPfam hit to PF02743, Cache domain, score 0.00011 192222001180 HMMPfam hit to PF05581, Vibrio chemotaxis protein N terminus, score 4.3e-68 192222001181 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 192222001182 ZIP Zinc transporter; Region: Zip; pfam02535 192222001183 HMMPfam hit to PF02535, ZIP Zinc transporter, score 5.8e-38 192222001184 8 probable transmembrane helices predicted for Cj0263 by TMHMM2.0 at aa 10-32, 39-60, 75-94, 148-170,174-196, 209-231, 237-259 and 271-290 192222001185 PS00107 Protein kinases ATP-binding region signature 192222001186 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 192222001187 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 192222001188 molybdopterin cofactor binding site [chemical binding]; other site 192222001189 substrate binding site [chemical binding]; other site 192222001190 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 192222001191 molybdopterin cofactor binding site; other site 192222001192 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 5.6e-41 192222001193 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3 192222001194 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 3.2e-120 192222001195 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001196 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 192222001197 PS00190 Cytochrome c family heme-binding site signature 192222001198 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 192222001199 PS00430 TonB-dependent receptor proteins signature 1 192222001200 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 192222001201 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 192222001202 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 192222001203 HMMPfam hit to PF01145, SPFH domain / Band, score 2.3e-37 192222001204 1 probable transmembrane helix predicted for Cj0268c by TMHMM2.0 at aa 44-66 192222001205 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 192222001206 homodimer interface [polypeptide binding]; other site 192222001207 substrate-cofactor binding pocket; other site 192222001208 catalytic residue [active] 192222001209 HMMPfam hit to PF01063, Aminotransferase class IV,score 6.2e-88 192222001210 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 192222001211 active site 1 [active] 192222001212 dimer interface [polypeptide binding]; other site 192222001213 hexamer interface [polypeptide binding]; other site 192222001214 active site 2 [active] 192222001215 HMMPfam hit to PF01361, Tautomerase enzyme, score 1.4e-21 192222001216 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 192222001217 catalytic triad [active] 192222001218 HMMPfam hit to PF00578, AhpC/TSA family, score 4e-41 192222001219 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 192222001220 Ligand Binding Site [chemical binding]; other site 192222001221 HMMPfam hit to PF02677, Uncharacterized BCR,COG1636, score 2.6e-97 192222001222 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 192222001223 HMMPfam hit to PF03061, Thioesterase superfamily,score 2.4e-21 192222001224 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 192222001225 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 192222001226 active site 192222001227 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.78 192222001228 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.072 192222001229 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.3 192222001230 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.075 192222001231 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.011 192222001232 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 2.8 192222001233 PS00101 Hexapeptide-repeat containing-transferases signature 192222001234 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 50 192222001235 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 192222001236 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 192222001237 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222001238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 192222001239 Walker A motif; other site 192222001240 ATP binding site [chemical binding]; other site 192222001241 Walker B motif; other site 192222001242 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 192222001243 HMMPfam hit to PF06689, ClpX C4-type zinc finger,score 3.2e-14 192222001244 HMMPfam hit to PF07724, ATPase family associated with various cell, score 2.7e-77 192222001245 HMMPfam hit to PF00004, ATPase family associated with various cell, score 1.1e-26 192222001246 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001247 PS00676 Sigma-54 interaction domain ATP-binding region B signature 192222001248 rod shape-determining protein MreB; Provisional; Region: PRK13927 192222001249 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 192222001250 ATP binding site [chemical binding]; other site 192222001251 gelsolin binding site; other site 192222001252 profilin binding site; other site 192222001253 HMMPfam hit to PF06723, MreB/Mbl protein, score 6.5e-229 192222001254 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001255 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 192222001256 rod shape-determining protein MreC; Region: MreC; pfam04085 192222001257 1 probable transmembrane helix predicted for Cj0277 by TMHMM2.0 at aa 5-24 192222001258 HMMPfam hit to PF04085, rod shape-determining protein MreC, score 2.4e-43 192222001259 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 192222001260 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 192222001261 ATP-grasp domain; Region: ATP-grasp_4; cl03087 192222001262 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 192222001263 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 192222001264 ATP-grasp domain; Region: ATP-grasp_4; cl03087 192222001265 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 192222001266 IMP binding site; other site 192222001267 dimer interface [polypeptide binding]; other site 192222001268 interdomain contacts; other site 192222001269 partial ornithine binding site; other site 192222001270 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 1.8e-45 192222001271 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001272 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 2.3e-112 192222001273 PS00866 Carbamoyl-phosphate synthase subdomain signature 1 192222001274 PS00867 Carbamoyl-phosphate synthase subdomain signature 2 192222001275 HMMPfam hit to PF02787, Carbamoyl-phosphate synthetase large c, score 2.8e-46 192222001276 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 3.2e-19 192222001277 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 8e-25 192222001278 PS00866 Carbamoyl-phosphate synthase subdomain signature 1 192222001279 PS00867 Carbamoyl-phosphate synthase subdomain signature 2 192222001280 HMMPfam hit to PF02142, MGS-like domain, score 2.5e-28 192222001281 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 192222001282 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 192222001283 putative active site [active] 192222001284 transaldolase; Provisional; Region: PRK03903 192222001285 catalytic residue [active] 192222001286 HMMPfam hit to PF00923, Transaldolase, score 7e-34 192222001287 PS01054 Transaldolase signature 1 192222001288 phosphoserine phosphatase SerB; Region: serB; TIGR00338 192222001289 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 192222001290 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 192222001291 motif II; other site 192222001292 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 5.8e-18 192222001293 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 192222001294 putative CheA interaction surface; other site 192222001295 HMMPfam hit to PF01584, CheW-like domain, score 5.9e-30 192222001296 chemotaxis protein CheA; Provisional; Region: PRK10547 192222001297 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 192222001298 putative binding surface; other site 192222001299 active site 192222001300 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 192222001301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 192222001302 ATP binding site [chemical binding]; other site 192222001303 Mg2+ binding site [ion binding]; other site 192222001304 G-X-G motif; other site 192222001305 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 192222001306 Response regulator receiver domain; Region: Response_reg; pfam00072 192222001307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 192222001308 active site 192222001309 phosphorylation site [posttranslational modification] 192222001310 intermolecular recognition site; other site 192222001311 dimerization interface [polypeptide binding]; other site 192222001312 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.4e-25 192222001313 PS00217 Sugar transport proteins signature 2 192222001314 HMMPfam hit to PF01584, CheW-like domain, score 1.8e-28 192222001315 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 3.2e-28 192222001316 HMMPfam hit to PF02895, Signal transducing histidine kinase, hom, score 3.7e-24 192222001317 HMMPfam hit to PF01627, Hpt domain, score 5.4e-17 192222001318 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 192222001319 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 192222001320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 192222001321 active site 192222001322 phosphorylation site [posttranslational modification] 192222001323 intermolecular recognition site; other site 192222001324 dimerization interface [polypeptide binding]; other site 192222001325 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.1e-15 192222001326 HMMPfam hit to PF01584, CheW-like domain, score 1.6e-28 192222001327 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 192222001328 active site 192222001329 metal binding site [ion binding]; metal-binding site 192222001330 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 192222001331 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 192222001332 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 192222001333 HMMPfam hit to PF01272, Prokaryotic transcription elongation fact, score 3.2e-27 192222001334 PS00830 Prokaryotic transcription elongation factors signature 2 192222001335 HMMPfam hit to PF03449, Prokaryotic transcription elongation fact, score 1.4e-37 192222001336 PS00829 Prokaryotic transcription elongation factors signature 1 192222001337 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 192222001338 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 192222001339 HMMPfam hit to PF02684, Lipid-A-disaccharide synthetase, score 4.7e-81 192222001340 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 192222001341 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 192222001342 Original (2000) note: Cj0290c, probable pseudogene representing the C-terminus of Cj0291c (glpT'); Original (2000) note: Cj0292c, probable pseudogene representing the N-terminus of Cj0291c (glpT'); Original (2000) note: Cj0291c, glpT',glycerol-3-phosphate transporter, possible pseudogene,len: 319 aa; similar to the central region of many e.g. GLPT_ECOLI glycerol-3-phosphate transporter (452 aa),fasta scores; opt: 473 z-score: 832.3 E(): 0, 35.3% identity in 323 aa overlap. No Hp match. Contains PS00942 glpT family of transporters signature. Note that the N-terminal 100 aa and the C-terminal 50 aa present in other glpT proteins are out of frame, and are represented by the CDSs Cj0292c and Cj0290c respectively. The sequence has been checked, and is believed to be correct; Updated (2006) note: Pfam domain PF07690 Major Facilitator Superfamily identified within CDS. Also,twelve probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Coding sequence has been updated to reflect the complete amino acid sequence for the encoded protein regardless of its expression. This will cause differences from the amino acid sequence of the previous annotation. Functional classification - Transport/binding proteins -Carbohydrates, organic acids and alcohols 192222001343 Survival protein SurE; Region: SurE; cl00448 192222001344 HMMPfam hit to PF01975, Survival protein SurE,score 3.9e-78 192222001345 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 192222001346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222001347 ATP binding site [chemical binding]; other site 192222001348 substrate interface [chemical binding]; other site 192222001349 HMMPfam hit to PF00899, ThiF family, score 1.3e-09 192222001350 1 probable transmembrane helix predicted for Cj0294 by TMHMM2.0 at aa 26-43 192222001351 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 192222001352 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 192222001353 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.2e-07 192222001354 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 192222001355 tetramerization interface [polypeptide binding]; other site 192222001356 active site 192222001357 HMMPfam hit to PF02261, Aspartate decarboxylase,score 1.5e-61 192222001358 pantoate--beta-alanine ligase; Region: panC; TIGR00018 192222001359 Pantoate-beta-alanine ligase; Region: PanC; cd00560 192222001360 active site 192222001361 ATP-binding site [chemical binding]; other site 192222001362 pantoate-binding site; other site 192222001363 HXXH motif; other site 192222001364 HMMPfam hit to PF02569, Pantoate-beta-alanine ligase, score 4.1e-137 192222001365 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 192222001366 active site 192222001367 oligomerization interface [polypeptide binding]; other site 192222001368 metal binding site [ion binding]; metal-binding site 192222001369 HMMPfam hit to PF02548, Ketopantoate hydroxymethyltransferase, score 8.3e-137 192222001370 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 192222001371 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 1.3e-33 192222001372 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222001373 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 192222001374 Walker A/P-loop; other site 192222001375 ATP binding site [chemical binding]; other site 192222001376 Q-loop/lid; other site 192222001377 ABC transporter signature motif; other site 192222001378 Walker B; other site 192222001379 D-loop; other site 192222001380 H-loop/switch region; other site 192222001381 HMMPfam hit to PF00005, ABC transporter, score 6e-62 192222001382 PS00211 ABC transporters family signature 192222001383 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 192222001385 dimer interface [polypeptide binding]; other site 192222001386 conserved gate region; other site 192222001387 putative PBP binding loops; other site 192222001388 ABC-ATPase subunit interface; other site 192222001389 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 8.6e-19 192222001390 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001391 TOBE domain; Region: TOBE_2; cl01440 192222001392 HMMPfam hit to PF03459, TOBE domain, score 4.6e-06 192222001393 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 192222001394 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 192222001395 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 4.2e-13 192222001396 1 probable transmembrane helix predicted for Cj0303c by TMHMM2.0 at aa 5-27 192222001397 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001398 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 192222001399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 192222001400 S-adenosylmethionine binding site [chemical binding]; other site 192222001401 Protein of unknown function (DUF452); Region: DUF452; cl01062 192222001402 HMMPfam hit to PF04301, Protein of unknown function (DUF452), score 2.5e-153 192222001403 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 192222001404 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 192222001405 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 192222001406 catalytic residue [active] 192222001407 HMMPfam hit to PF00155, Aminotransferase class I and II, score 2e-07 192222001408 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site 192222001409 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 192222001410 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 192222001411 inhibitor-cofactor binding pocket; inhibition site 192222001412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222001413 catalytic residue [active] 192222001414 HMMPfam hit to PF00202, Aminotransferase class-III,score 4.3e-127 192222001415 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site 192222001416 AAA domain; Region: AAA_26; pfam13500 192222001417 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222001418 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 192222001419 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 4.2e-30 192222001420 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 192222001421 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 1.3e-12 192222001422 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 192222001423 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 192222001424 5S rRNA interface [nucleotide binding]; other site 192222001425 CTC domain interface [polypeptide binding]; other site 192222001426 L16 interface [polypeptide binding]; other site 192222001427 HMMPfam hit to PF01386, Ribosomal L25p family,score 1.5e-29 192222001428 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 192222001429 putative active site [active] 192222001430 catalytic residue [active] 192222001431 HMMPfam hit to PF01195, Peptidyl-tRNA hydrolase,score 4.2e-68 192222001432 PS01195 Peptidyl-tRNA hydrolase signature 1 192222001433 PS01196 Peptidyl-tRNA hydrolase signature 2 192222001434 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 192222001435 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 192222001436 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ family, score 5.8e-79 192222001437 6 probable transmembrane helices predicted for Cj0313 by TMHMM2.0 at aa 12-34, 49-71, 95-117, 270-292,294-316 and 326-348 192222001438 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001439 diaminopimelate decarboxylase; Region: lysA; TIGR01048 192222001440 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 192222001441 active site 192222001442 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 192222001443 substrate binding site [chemical binding]; other site 192222001444 catalytic residues [active] 192222001445 dimer interface [polypeptide binding]; other site 192222001446 HMMPfam hit to PF02784, Pyridoxal-dependent decarboxylase, py, score 2e-76 192222001447 HMMPfam hit to PF00278, Pyridoxal-dependent decarboxylase, C-, score 5.7e-33 192222001448 Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460 192222001449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 192222001450 active site 192222001451 motif I; other site 192222001452 motif II; other site 192222001453 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 192222001454 Chorismate mutase type II; Region: CM_2; cl00693 192222001455 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 192222001456 Prephenate dehydratase; Region: PDT; pfam00800 192222001457 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 192222001458 putative L-Phe binding site [chemical binding]; other site 192222001459 HMMPfam hit to PF01817, Chorismate mutase type II,score 1.9e-22 192222001460 HMMPfam hit to PF00800, Prephenate dehydratase,score 6.3e-56 192222001461 PS00857 Prephenate dehydratase signature 1 192222001462 HMMPfam hit to PF01842, ACT domain, score 0.00089 192222001463 PS00858 Prephenate dehydratase signature 2 192222001464 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 192222001465 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 192222001466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222001467 homodimer interface [polypeptide binding]; other site 192222001468 catalytic residue [active] 192222001469 HMMPfam hit to PF00155, Aminotransferase class I and II, score 6.6e-16 192222001470 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 192222001471 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 192222001472 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 192222001473 HMMPfam hit to PF01514, Secretory protein of YscJ/FliF family, score 3.9e-54 192222001474 1 probable transmembrane helix predicted for Cj0318 by TMHMM2.0 at aa 23-42 192222001475 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 192222001476 FliG C-terminal domain; Region: FliG_C; pfam01706 192222001477 HMMPfam hit to PF01706, FliG C-terminal domain,score 7.5e-48 192222001478 flagellar assembly protein H; Validated; Region: fliH; PRK06669 192222001479 Flagellar assembly protein FliH; Region: FliH; pfam02108 192222001480 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 192222001481 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 192222001482 TPP-binding site; other site 192222001483 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 192222001484 PYR/PP interface [polypeptide binding]; other site 192222001485 dimer interface [polypeptide binding]; other site 192222001486 TPP binding site [chemical binding]; other site 192222001487 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 192222001488 PS00801 Transketolase signature 1 192222001489 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001490 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 2.1e-48 192222001491 PS00802 Transketolase signature 2 192222001492 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 6.3e-11 192222001493 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 192222001494 metal binding site 2 [ion binding]; metal-binding site 192222001495 putative DNA binding helix; other site 192222001496 metal binding site 1 [ion binding]; metal-binding site 192222001497 structural Zn2+ binding site [ion binding]; other site 192222001498 HMMPfam hit to PF01475, Ferric uptake regulator family, score 4.3e-22 192222001499 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 192222001500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 192222001501 S-adenosylmethionine binding site [chemical binding]; other site 192222001502 HMMPfam hit to PF01209, ubiE/COQ5 methyltransferase family, score 2.2e-28 192222001503 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 192222001504 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 192222001505 generic binding surface II; other site 192222001506 generic binding surface I; other site 192222001507 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 6.9e-11 192222001508 HMMPfam hit to PF02601, Exonuclease VII, large subunit, score 1.1e-27 192222001509 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 192222001510 homodimer interface [polypeptide binding]; other site 192222001511 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 192222001512 substrate-cofactor binding pocket; other site 192222001513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222001514 catalytic residue [active] 192222001515 HMMPfam hit to PF00266, Aminotransferase class-V,score 3.6e-37 192222001516 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 192222001517 homotrimer interaction site [polypeptide binding]; other site 192222001518 putative active site [active] 192222001519 HMMPfam hit to PF01042, Endoribonuclease L-PSP,score 3.8e-16 192222001520 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 192222001521 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 192222001522 dimer interface [polypeptide binding]; other site 192222001523 active site 192222001524 CoA binding pocket [chemical binding]; other site 192222001525 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 192222001526 HMMPfam hit to PF02504, Fatty acid synthesis protein, score 1.6e-141 192222001527 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 192222001528 HMMPfam hit to PF01783, Ribosomal L32p protein family, score 1.8e-05 192222001529 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 192222001530 active site 192222001531 multimer interface [polypeptide binding]; other site 192222001532 HMMPfam hit to PF00334, Nucleoside diphosphate kinase, score 6e-80 192222001533 PS00469 Nucleoside diphosphate kinases active site 192222001534 4Fe-4S binding domain; Region: Fer4; cl02805 192222001535 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 192222001536 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 2.9e-06 192222001537 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222001538 peroxidase; Provisional; Region: PRK15000 192222001539 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 192222001540 dimer interface [polypeptide binding]; other site 192222001541 decamer (pentamer of dimers) interface [polypeptide binding]; other site 192222001542 catalytic triad [active] 192222001543 peroxidatic and resolving cysteines [active] 192222001544 HMMPfam hit to PF00578, AhpC/TSA family, score 8.6e-60 192222001545 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 192222001546 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 192222001547 HMMPfam hit to PF01312, FlhB HrpN YscU SpaS Family,score 2.4e-119 192222001548 4 probable transmembrane helices predicted for Cj0335 by TMHMM2.0 at aa 32-54, 83-105, 141-163 and 188-210 192222001549 flagellar motor protein MotB; Reviewed; Region: motB; PRK08457 192222001550 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 192222001551 ligand binding site [chemical binding]; other site 192222001552 HMMPfam hit to PF00691, OmpA family, score 9.1e-07 192222001553 1 probable transmembrane helix predicted for Cj0336c by TMHMM2.0 at aa 16-38 192222001554 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 192222001555 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 192222001556 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 5.5e-09 192222001557 PS01307 Flagellar motor protein motA family signature 192222001558 DNA polymerase I; Provisional; Region: PRK05755 192222001559 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 192222001560 active site 192222001561 metal binding site 1 [ion binding]; metal-binding site 192222001562 putative 5' ssDNA interaction site; other site 192222001563 metal binding site 3; metal-binding site 192222001564 metal binding site 2 [ion binding]; metal-binding site 192222001565 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 192222001566 putative DNA binding site [nucleotide binding]; other site 192222001567 putative metal binding site [ion binding]; other site 192222001568 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 192222001569 active site 192222001570 catalytic site [active] 192222001571 substrate binding site [chemical binding]; other site 192222001572 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 192222001573 active site 192222001574 DNA binding site [nucleotide binding] 192222001575 catalytic site [active] 192222001576 HMMPfam hit to PF00476, DNA polymerase family A,score 3.2e-110 192222001577 PS00447 DNA polymerase family A signature 192222001578 HMMPfam hit to PF01612, 3'-5' exonuclease, score 3e-25 192222001579 HMMPfam hit to PF01367, 5'-3' exonuclease,C-terminal SAM fold, score 4.4e-42 192222001580 HMMPfam hit to PF02739, 5'-3' exonuclease,N-terminal resolvase-, score 5.4e-48 192222001581 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 192222001583 metabolite-proton symporter; Region: 2A0106; TIGR00883 192222001584 putative substrate translocation pore; other site 192222001585 HMMPfam hit to PF00083, Sugar (and other) transporter, score 1.3e-35 192222001586 10 probable transmembrane helices predicted for Cj0339 by TMHMM2.0 at aa 30-52, 62-84, 105-127, 164-186,198-220, 294-316, 323-342, 352-374, 394-413 and 417-439 192222001587 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.5e-24 192222001588 nuc_hydro_CjNH. Nucleoside hydrolases similar to Campylobacter jejuni nucleoside hydrolase. This group contains eukaryotic and bacterial proteins similar to C. jejuni nucleoside hydrolase. Nucleoside hydrolases cleave the N-glycosidic bond in...; Region: nuc_hydro_CjNH; cd02654 192222001589 active site 192222001590 HMMPfam hit to PF01156, Inosine-uridine preferring nucleoside hy, score 5.1e-18 192222001591 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 192222001592 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 192222001593 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 192222001594 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 192222001595 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 192222001596 HMMPfam hit to PF00005, ABC transporter, score 9.1e-19 192222001597 PS00211 ABC transporters family signature 192222001598 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001599 PS00211 ABC transporters family signature 192222001600 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001601 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 192222001602 HMMPfam hit to PF01925, Domain of unknown function DUF81, score 2.6e-34 192222001603 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001604 chorismate binding enzyme; Region: Chorismate_bind; cl10555 192222001605 HMMPfam hit to PF00425, chorismate binding enzyme,score 1.1e-90 192222001606 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 192222001607 Glutamine amidotransferase class-I; Region: GATase; pfam00117 192222001608 glutamine binding [chemical binding]; other site 192222001609 catalytic triad [active] 192222001610 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 192222001611 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 192222001612 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 192222001613 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 5.4e-61 192222001614 PS00442 Glutamine amidotransferases class-I active site 192222001615 HMMPfam hit to PF00591, Glycosyl transferase family, a/b doma, score 2.5e-78 192222001616 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 192222001617 active site 192222001618 HMMPfam hit to PF00697,N-(5'phosphoribosyl)anthranilate (PRA) isome, score 4.5e-31 192222001619 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 192222001620 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 192222001621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222001622 catalytic residue [active] 192222001623 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 1.8e-108 192222001624 PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site 192222001625 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001626 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 192222001627 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 192222001628 substrate binding site [chemical binding]; other site 192222001629 active site 192222001630 catalytic residues [active] 192222001631 heterodimer interface [polypeptide binding]; other site 192222001632 HMMPfam hit to PF00290, Tryptophan synthase alpha chain, score 2.2e-73 192222001633 PS00167 Tryptophan synthase alpha chain signature 192222001634 Chemotaxis phosphatase CheX; Region: CheX; cl15816 192222001635 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 192222001636 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 9e-34 192222001637 2 probable transmembrane helices predicted for Cj0352 by TMHMM2.0 at aa 5-24 and 153-170 192222001638 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 192222001639 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 192222001640 HMMPfam hit to PF02541, Ppx/GppA phosphatase family, score 1.5e-46 192222001641 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 192222001642 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.0069 192222001643 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222001644 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 192222001645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 192222001646 active site 192222001647 phosphorylation site [posttranslational modification] 192222001648 intermolecular recognition site; other site 192222001649 dimerization interface [polypeptide binding]; other site 192222001650 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 192222001651 DNA binding site [nucleotide binding] 192222001652 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 4.2e-20 192222001653 HMMPfam hit to PF00072, Response regulator receiver domain, score 4e-19 192222001654 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 192222001655 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 192222001656 PS00294 Prenyl group binding site (CAAX box) 192222001657 HMMPfam hit to PF02660, Domain of unknown function DUF, score 1.3e-44 192222001658 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 192222001659 HMMPfam hit to PF03150, Di-haem cytochrome c peroxidase, score 1.4e-78 192222001660 PS00190 Cytochrome c family heme-binding site signature 192222001661 PS00190 Cytochrome c family heme-binding site signature 192222001662 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14324 192222001663 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 192222001664 active site 192222001665 substrate binding site [chemical binding]; other site 192222001666 metal binding site [ion binding]; metal-binding site 192222001667 HMMPfam hit to PF02878,Phosphoglucomutase/phosphomannomutase, al, score 2.8e-60 192222001668 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature 192222001669 HMMPfam hit to PF02879,Phosphoglucomutase/phosphomannomutase, al, score 2.6e-37 192222001670 HMMPfam hit to PF02880,Phosphoglucomutase/phosphomannomutase, al, score 2.5e-31 192222001671 HMMPfam hit to PF00408,Phosphoglucomutase/phosphomannomutase, C-, score 5.8e-06 192222001672 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 192222001673 lipoprotein signal peptidase; Provisional; Region: PRK14787 192222001674 4 probable transmembrane helices predicted for Cj0361 by TMHMM2.0 at aa 7-24, 39-58, 65-84 and 120-142 192222001675 HMMPfam hit to PF01252, Signal peptidase (SPase) II, score 9.9e-41 192222001676 PS00855 Signal peptidases II signature 192222001677 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 192222001678 HMMPfam hit to PF03653, Uncharacterised protein family (UPF0093), score 9e-53 192222001679 4 probable transmembrane helices predicted for Cj0362 by TMHMM2.0 at aa 15-36, 57-79, 83-105 and 126-148 192222001680 coproporphyrinogen III oxidase; Provisional; Region: PRK08629 192222001681 HMMPfam hit to PF06969, HemN C-terminal region,score 0.0012 192222001682 HMMPfam hit to PF04055, Radical SAM superfamily,score 3.4e-21 192222001683 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 192222001684 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.6e-27 192222001685 HMMPfam hit to PF02321, Outer membrane efflux protein, score 3.2e-33 192222001686 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001687 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 192222001688 Protein export membrane protein; Region: SecD_SecF; cl14618 192222001689 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family,score 0 192222001690 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 192222001691 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 192222001692 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 192222001693 HMMPfam hit to PF00529, HlyD family secretion protein, score 2.9e-21 192222001694 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001695 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 192222001696 Helix-turn-helix domains; Region: HTH; cl00088 192222001697 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 7.1e-10 192222001698 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 192222001699 4Fe-4S binding domain; Region: Fer4_5; pfam12801 192222001700 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 192222001701 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 192222001702 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.0014 192222001703 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222001704 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 192222001705 HMMPfam hit to PF01165, Ribosomal protein S21,score 1.1e-24 192222001706 hypothetical protein; Provisional; Region: PRK04081 192222001707 1 probable transmembrane helix predicted for Cj0371 by TMHMM2.0 at aa 7-29 192222001708 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001709 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 192222001710 HMMPfam hit to PF03738, Glutathionylspermidine synthase, score 3.6e-252 192222001711 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 192222001712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222001713 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 3.7e-21 192222001714 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 1.4e-41 192222001715 PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3 192222001716 Protein of unknown function (DUF520); Region: DUF520; cl00723 192222001717 HMMPfam hit to PF04461, Protein of unknown function (DUF520), score 3.7e-100 192222001718 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001719 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 192222001720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 192222001721 Walker A motif; other site 192222001722 ATP binding site [chemical binding]; other site 192222001723 Walker B motif; other site 192222001724 arginine finger; other site 192222001725 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.4e-36 192222001726 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001727 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 192222001728 HMMPfam hit to PF05252, Uncharacterised protein family (UPF0191), score 1.2e-08 192222001729 TMAO/DMSO reductase; Reviewed; Region: PRK05363 192222001730 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 192222001731 Moco binding site; other site 192222001732 metal coordination site [ion binding]; other site 192222001733 HMMPfam hit to PF00174, Oxidoreductase molybdopterin binding d, score 3.2e-05 192222001734 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 192222001735 active site 192222001736 dimer interface [polypeptide binding]; other site 192222001737 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase / HUMP, score 7.3e-82 192222001738 PS00156 Orotidine 5'-phosphate decarboxylase active site 192222001739 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 192222001740 putative RNA binding site [nucleotide binding]; other site 192222001741 HMMPfam hit to PF01029, NusB family, score 1.9e-36 192222001742 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 192222001743 homopentamer interface [polypeptide binding]; other site 192222001744 active site 192222001745 HMMPfam hit to PF00885,6,7-dimethyl-8-ribityllumazine synthase, score 1.8e-77 192222001746 NeuB family; Region: NeuB; cl00496 192222001747 HMMPfam hit to PF00793, DAHP synthetase I family,score 9.7e-105 192222001748 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001749 EamA-like transporter family; Region: EamA; cl01037 192222001750 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 192222001751 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 6.9e-16 192222001752 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001753 GTP-binding protein Der; Reviewed; Region: PRK00093 192222001754 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 192222001755 G1 box; other site 192222001756 GTP/Mg2+ binding site [chemical binding]; other site 192222001757 Switch I region; other site 192222001758 G2 box; other site 192222001759 Switch II region; other site 192222001760 G3 box; other site 192222001761 G4 box; other site 192222001762 G5 box; other site 192222001763 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 192222001764 GTP/Mg2+ binding site [chemical binding]; other site 192222001765 Switch I region; other site 192222001766 G2 box; other site 192222001767 G3 box; other site 192222001768 Switch II region; other site 192222001769 G4 box; other site 192222001770 G5 box; other site 192222001771 HMMPfam hit to PF01926, GTPase of unknown function,score 2.7e-36 192222001772 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001773 HMMPfam hit to PF01926, GTPase of unknown function,score 1.3e-39 192222001774 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001775 shikimate kinase; Reviewed; Region: aroK; PRK00131 192222001776 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 192222001777 ADP binding site [chemical binding]; other site 192222001778 magnesium binding site [ion binding]; other site 192222001779 putative shikimate binding site; other site 192222001780 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001781 HMMPfam hit to PF01202, Shikimate kinase, score 3.6e-48 192222001782 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 192222001783 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 192222001784 active site 192222001785 HIGH motif; other site 192222001786 dimer interface [polypeptide binding]; other site 192222001787 KMSKS motif; other site 192222001788 HMMPfam hit to PF00579, tRNA synthetases class I (W and Y), score 1.1e-66 192222001789 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 192222001790 seryl-tRNA synthetase; Provisional; Region: PRK05431 192222001791 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 192222001792 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 192222001793 dimer interface [polypeptide binding]; other site 192222001794 active site 192222001795 motif 1; other site 192222001796 motif 2; other site 192222001797 motif 3; other site 192222001798 HMMPfam hit to PF02403, Seryl-tRNA synthetase N-terminal domain, score 9.1e-26 192222001799 HMMPfam hit to PF00587, tRNA synthetase class II core domain (G,, score 1.4e-52 192222001800 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 192222001801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 192222001802 binding surface 192222001803 TPR motif; other site 192222001804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 192222001805 TPR motif; other site 192222001806 1 probable transmembrane helix predicted for Cj0390 by TMHMM2.0 at aa 90-112 192222001807 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 0.12; HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.032 192222001808 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 0.43 192222001809 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.15; HMMPfam hit to PF00515, Tetratricopeptide repeat,score 0.034 192222001810 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 5.3e-06; HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.00052 192222001811 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 192222001812 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 192222001813 domain interfaces; other site 192222001814 active site 192222001815 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta domain, score 1.4e-11 192222001816 HMMPfam hit to PF00224, Pyruvate kinase, barrel domain, score 2.4e-135 192222001817 PS00659 Glycosyl hydrolases family 5 signature 192222001818 Predicted dehydrogenase [General function prediction only]; Region: COG0579 192222001819 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222001820 HMMPfam hit to PF06039, Malate:quinone oxidoreductase (Mqo), score 1.3e-08 192222001821 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001822 PS00110 Pyruvate kinase active site signature 192222001823 Type III pantothenate kinase; Region: Pan_kinase; cl09130 192222001824 HMMPfam hit to PF03309, Bordetella pertussis Bvg accessory fac, score 7.3e-09 192222001825 PQQ-like domain; Region: PQQ_2; pfam13360 192222001826 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001827 1 probable transmembrane helix predicted for Cj0397c by TMHMM2.0 at aa 36-55 192222001828 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 192222001829 HMMPfam hit to PF02686, Glu-tRNAGln amidotransferase C subunit, score 5.1e-09 192222001830 Colicin V production protein; Region: Colicin_V; cl00567 192222001831 HMMPfam hit to PF02674, Colicin V production protein, score 1.4e-48 192222001832 4 probable transmembrane helices predicted for Cj0399 by TMHMM2.0 at aa 5-27, 31-48, 68-90 and 105-127 192222001833 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001834 ferric uptake regulator; Provisional; Region: fur; PRK09462 192222001835 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 192222001836 metal binding site 2 [ion binding]; metal-binding site 192222001837 putative DNA binding helix; other site 192222001838 metal binding site 1 [ion binding]; metal-binding site 192222001839 dimer interface [polypeptide binding]; other site 192222001840 structural Zn2+ binding site [ion binding]; other site 192222001841 HMMPfam hit to PF01475, Ferric uptake regulator family, score 1.4e-63 192222001842 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 192222001843 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 192222001844 dimer interface [polypeptide binding]; other site 192222001845 putative anticodon binding site; other site 192222001846 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 192222001847 motif 1; other site 192222001848 active site 192222001849 motif 2; other site 192222001850 motif 3; other site 192222001851 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 5e-15 192222001852 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 4.6e-205 192222001853 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 192222001854 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 192222001855 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 192222001856 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 192222001857 dimer interface [polypeptide binding]; other site 192222001858 active site 192222001859 glycine-pyridoxal phosphate binding site [chemical binding]; other site 192222001860 folate binding site [chemical binding]; other site 192222001861 HMMPfam hit to PF00464, Serine hydroxymethyltransferase, score 1.9e-282 192222001862 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site 192222001863 Domain of unknown function (DUF1882); Region: DUF1882; pfam08966 192222001864 Sporulation related domain; Region: SPOR; cl10051 192222001865 1 probable transmembrane helix predicted for Cj0404 by TMHMM2.0 at aa 25-42 192222001866 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 192222001867 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 192222001868 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 192222001869 shikimate binding site; other site 192222001870 NAD(P) binding site [chemical binding]; other site 192222001871 HMMPfam hit to PF01488, Shikimate / quinate 5-dehydrogenase, score 8.1e-54 192222001872 1 probable transmembrane helix predicted for Cj0406c by TMHMM2.0 at aa 5-27 192222001873 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001874 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 192222001875 HMMPfam hit to PF01790, Prolipoprotein diacylglyceryl transferase, score 4e-120 192222001876 7 probable transmembrane helices predicted for Cj0407 by TMHMM2.0 at aa 23-45, 66-88, 103-125, 132-154,184-201, 206-225 and 240-262 192222001877 PS01311 Prolipoprotein diacylglyceryl transferase signature 192222001878 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 192222001879 Iron-sulfur protein interface; other site 192222001880 proximal heme binding site [chemical binding]; other site 192222001881 distal heme binding site [chemical binding]; other site 192222001882 dimer interface [polypeptide binding]; other site 192222001883 HMMPfam hit to PF02967, Fumarate reductase respiratory complex, tr, score 8e-102 192222001884 PS00228 Tubulin-beta mRNA autoregulation signal 192222001885 5 probable transmembrane helices predicted for Cj0408 by TMHMM2.0 at aa 29-51, 73-95, 125-147, 167-189 and 213-235 192222001886 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001887 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 192222001888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222001889 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 192222001890 HMMPfam hit to PF00890, FAD binding domain, score 2e-160 192222001891 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydroge, score 6.4e-53 192222001892 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 192222001893 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 192222001894 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 192222001895 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 0.0037 192222001896 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature 192222001897 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.0015 192222001898 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001899 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 192222001900 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222001901 Dynamin family; Region: Dynamin_N; pfam00350 192222001902 G1 box; other site 192222001903 GTP/Mg2+ binding site [chemical binding]; other site 192222001904 G2 box; other site 192222001905 Switch I region; other site 192222001906 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 192222001907 G3 box; other site 192222001908 Switch II region; other site 192222001909 GTP/Mg2+ binding site [chemical binding]; other site 192222001910 G4 box; other site 192222001911 G5 box; other site 192222001912 HMMPfam hit to PF01926, GTPase of unknown function,score 2e-08 192222001913 HMMPfam hit to PF00350, Dynamin family, score 8.1e-52 192222001914 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001915 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 192222001916 Dynamin family; Region: Dynamin_N; pfam00350 192222001917 G1 box; other site 192222001918 GTP/Mg2+ binding site [chemical binding]; other site 192222001919 G2 box; other site 192222001920 Switch I region; other site 192222001921 G3 box; other site 192222001922 Switch II region; other site 192222001923 G4 box; other site 192222001924 G5 box; other site 192222001925 HMMPfam hit to PF01926, GTPase of unknown function,score 1.5e-07 192222001926 HMMPfam hit to PF00350, Dynamin family, score 6.6e-39 192222001927 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001928 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 192222001929 Sel1 repeat; Region: Sel1; cl02723 192222001930 Sel1 repeat; Region: Sel1; cl02723 192222001931 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.013 192222001932 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 192222001933 1 probable transmembrane helix predicted for Cj0414 by TMHMM2.0 at aa 11-33 192222001934 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 192222001935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222001936 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 192222001937 SprA-related family; Region: SprA-related; pfam12118 192222001938 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 192222001939 YceI-like domain; Region: YceI; cl01001 192222001940 HMMPfam hit to PF04264, YceI like family, score 1e-77 192222001941 Helix-turn-helix domains; Region: HTH; cl00088 192222001942 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 192222001943 2 probable transmembrane helices predicted for Cj0423 by TMHMM2.0 at aa 5-27 and 37-59 192222001944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 192222001945 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222001946 HMMPfam hit to PF07661, MORN repeat variant, score 3.3 192222001947 HMMPfam hit to PF07661, MORN repeat variant, score 0.0044 192222001948 HMMPfam hit to PF07661, MORN repeat variant, score 0.0016 192222001949 HMMPfam hit to PF07661, MORN repeat variant, score 43 192222001950 HMMPfam hit to PF07661, MORN repeat variant, score 0.12 192222001951 HMMPfam hit to PF07661, MORN repeat variant, score 0.0083 192222001952 HMMPfam hit to PF07661, MORN repeat variant, score 4.1 192222001953 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 192222001954 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222001955 Walker A/P-loop; other site 192222001956 ATP binding site [chemical binding]; other site 192222001957 Q-loop/lid; other site 192222001958 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 192222001959 ABC transporter; Region: ABC_tran_2; pfam12848 192222001960 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 192222001961 HMMPfam hit to PF00005, ABC transporter, score 1.9e-33 192222001962 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001963 HMMPfam hit to PF00005, ABC transporter, score 1.1e-33 192222001964 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001965 S-layer like family, C-terminal region; Region: S_layer_C; pfam05124 192222001966 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 192222001967 HMMPfam hit to PF01205, Uncharacterized protein family UPF0029, score 3.1e-47 192222001968 9 probable transmembrane helices predicted for Cj0430 by TMHMM2.0 at aa 9-31, 69-91, 104-137, 147-169,176-195, 205-227, 239-256, 260-277 and 298-320 192222001969 1 probable transmembrane helix predicted for Cj0431 by TMHMM2.0 at aa 5-27 192222001970 PS00017 ATP/GTP-binding site motif A (P-loop) 192222001971 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03815 192222001972 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 192222001973 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 192222001974 HMMPfam hit to PF02875, Mur ligase family,glutamate ligase doma, score 0.00084 192222001975 HMMPfam hit to PF01225, Mur ligase family,catalytic domain, score 9.5e-09 192222001976 PS01011 Folylpolyglutamate synthase signature 1 192222001977 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 192222001978 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 192222001979 Mg++ binding site [ion binding]; other site 192222001980 putative catalytic motif [active] 192222001981 putative substrate binding site [chemical binding]; other site 192222001982 HMMPfam hit to PF00953, Glycosyl transferase, score 2.9e-62 192222001983 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 192222001984 Sulfatase; Region: Sulfatase; cl10460 192222001985 HMMPfam hit to PF06415, BPG-independent PGAM N-terminus (iPGM_N, score 1.4e-217 192222001986 HMMPfam hit to PF01676, Metalloenzyme superfamily,score 4.8e-35 192222001987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222001988 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 192222001989 NAD(P) binding site [chemical binding]; other site 192222001990 active site 192222001991 HMMPfam hit to PF00106, short chain dehydrogenase,score 3.3e-73 192222001992 PS00061 Short-chain dehydrogenases/reductases family signature 192222001993 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 192222001994 HMMPfam hit to PF01243, Pyridoxamine 5'-phosphate oxidase, score 9.8e-09 192222001995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222001996 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 192222001997 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 192222001998 HMMPfam hit to PF00890, FAD binding domain, score 6.2e-115 192222001999 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydroge, score 1.6e-35 192222002000 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 192222002001 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 192222002002 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 0.018 192222002003 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature 192222002004 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222002005 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 192222002006 Cysteine-rich domain; Region: CCG; pfam02754 192222002007 Cysteine-rich domain; Region: CCG; pfam02754 192222002008 HMMPfam hit to PF02754, Cysteine-rich domain, score 3.7e-06 192222002009 HMMPfam hit to PF02754, Cysteine-rich domain, score 6.4e-11 192222002010 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 192222002011 HMMPfam hit to PF03070, TENA/THI-4 family, score 1.2e-52 192222002012 Phosphopantetheine attachment site; Region: PP-binding; cl09936 192222002013 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 3.2e-13 192222002014 PS00012 Phosphopantetheine attachment site 192222002015 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 192222002016 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 192222002017 dimer interface [polypeptide binding]; other site 192222002018 active site 192222002019 HMMPfam hit to PF00109, Beta-ketoacyl synthase,N-terminal do, score 1.1e-67 192222002020 HMMPfam hit to PF02801, Beta-ketoacyl synthase,C-terminal do, score 8.4e-54 192222002021 PS00107 Protein kinases ATP-binding region signature 192222002022 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 192222002023 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 192222002024 HMMPfam hit to PF03255, Acetyl co-enzyme A carboxylase carboxyltrans, score 3.3e-66 192222002025 Original (2000) note: Cj0444, probable tonB-denpendent outer membrane receptor pseudogene, len: 2072 bp; similar to parts of various tonB-denpendent outer membrane receptors e.g. IRGA_VIBCH iron-regulated outer membrane virulence protein (652 aa), CIRA_ECOLI colicin I receptor precursor (663 aa), and FEPA_ECOLI ferrienterobactin receptor precursor (746 aa). No Hp ortholog. Contains N-terminal signal sequence, PS01156 TonB-dependent receptor proteins signature 2 and Pfam match to entry PF00593 TonB_boxC, TonB dependant receptor C-terminal region, score 28.00, E-value 4.3e-05. There is at least one frameshift and one stop codon in this CDS; Updated (2006) note: Pfam domain PF07715 TonB-dependent Receptor Plug Domain identified within CDS. Further support given to product function. Some characterisation work in various bacteria. However,identity scores were marginal. Thus, was added to product function. Coding sequence has been updated to reflect the complete amino acid sequence for the encoded protein regardless of its expression. This will cause differences from the amino acid sequence of the previous annotation. Functional classification - Transport/binding proteins - Other; PMID:15632442 192222002026 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 2e-27 192222002027 HMMPfam hit to PF00593, TonB dependent receptor,score 3.1e-33 192222002028 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 192222002029 dimer interface [polypeptide binding]; other site 192222002030 ADP-ribose binding site [chemical binding]; other site 192222002031 active site 192222002032 nudix motif; other site 192222002033 metal binding site [ion binding]; metal-binding site 192222002034 HMMPfam hit to PF00293, NUDIX domain, score 7.3e-11 192222002035 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 192222002036 dimer interface [polypeptide binding]; other site 192222002037 putative CheW interface [polypeptide binding]; other site 192222002038 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 192222002039 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 7.4e-12 192222002040 Protein of unknown function (DUF465); Region: DUF465; cl01070 192222002041 HMMPfam hit to PF04325, Protein of unknown function (DUF465), score 9.2e-21 192222002042 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 192222002043 HMMPfam hit to PF00830, Ribosomal L28 family, score 1.3e-23 192222002044 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 192222002045 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 192222002046 substrate binding site [chemical binding]; other site 192222002047 hexamer interface [polypeptide binding]; other site 192222002048 metal binding site [ion binding]; metal-binding site 192222002049 HMMPfam hit to PF00834, Ribulose-phosphate 3 epimerase family, score 2.7e-102 192222002050 PS01085 Ribulose-phosphate 3-epimerase family signature 1 192222002051 PS01086 Ribulose-phosphate 3-epimerase family signature 2 192222002052 DNA polymerase III subunit epsilon; Provisional; Region: PRK08517 192222002053 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 192222002054 active site 192222002055 catalytic site [active] 192222002056 substrate binding site [chemical binding]; other site 192222002057 HMMPfam hit to PF00929, Exonuclease, score 1.1e-35 192222002058 ThiC family; Region: ThiC; cl08031 192222002059 HMMPfam hit to PF01964, ThiC family, score 8.1e-216 192222002060 1 probable transmembrane helix predicted for Cj0454c by TMHMM2.0 at aa 29-51 192222002061 1 probable transmembrane helix predicted for Cj0455c by TMHMM2.0 at aa 20-39 192222002062 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 192222002063 putative acyl-acceptor binding pocket; other site 192222002064 HMMPfam hit to PF04028, Domain of unknown function (DUF374), score 1.7e-50 192222002065 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222002066 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 192222002067 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14339 192222002068 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 192222002069 FeS/SAM binding site; other site 192222002070 TRAM domain; Region: TRAM; cl01282 192222002071 HMMPfam hit to PF01938, TRAM domain, score 2.9e-10 192222002072 HMMPfam hit to PF04055, Radical SAM superfamily,score 3.8e-32 192222002073 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature 192222002074 PS01278 Uncharacterized protein family UPF0004 signature 192222002075 HMMPfam hit to PF00919, Uncharacterized protein family UPF0004, score 1.6e-40 192222002076 transcription elongation factor NusA; Provisional; Region: nusA; PRK12328 192222002077 NusA N-terminal domain; Region: NusA_N; pfam08529 192222002078 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 192222002079 RNA binding site [nucleotide binding]; other site 192222002080 homodimer interface [polypeptide binding]; other site 192222002081 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 192222002082 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 192222002083 G-X-X-G motif; other site 192222002084 H+ Antiporter protein; Region: 2A0121; TIGR00900 192222002085 HMMPfam hit to PF04332, Protein of unknown function (DUF475), score 3e-192 192222002086 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.2e-15 192222002087 hypothetical protein; Provisional; Region: PRK08445 192222002088 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 192222002089 FeS/SAM binding site; other site 192222002090 HMMPfam hit to PF04055, Radical SAM superfamily,score 9.3e-25 192222002091 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 192222002092 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 192222002093 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 1.5e-34 192222002094 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 192222002095 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 192222002096 generic binding surface II; other site 192222002097 ssDNA binding site; other site 192222002098 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 192222002099 ATP binding site [chemical binding]; other site 192222002100 putative Mg++ binding site [ion binding]; other site 192222002101 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 192222002102 nucleotide binding region [chemical binding]; other site 192222002103 ATP-binding site [chemical binding]; other site 192222002104 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 4.1e-06 192222002105 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 6.9e-25 192222002106 PS00017 ATP/GTP-binding site motif A (P-loop) 192222002107 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 2.2e-13 192222002108 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 192222002109 apolar tunnel; other site 192222002110 heme binding site [chemical binding]; other site 192222002111 dimerization interface [polypeptide binding]; other site 192222002112 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 192222002113 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 192222002114 ligand binding site [chemical binding]; other site 192222002115 flexible hinge region; other site 192222002116 Helix-turn-helix domains; Region: HTH; cl00088 192222002117 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 2.2e-15 192222002118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 192222002119 dimer interface [polypeptide binding]; other site 192222002120 conserved gate region; other site 192222002121 putative PBP binding loops; other site 192222002122 ABC-ATPase subunit interface; other site 192222002123 3 probable transmembrane helices predicted for Cj0467 by TMHMM2.0 at aa 15-37, 151-173 and 204-226 192222002124 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.8e-15 192222002125 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign 192222002126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 192222002127 dimer interface [polypeptide binding]; other site 192222002128 conserved gate region; other site 192222002129 putative PBP binding loops; other site 192222002130 ABC-ATPase subunit interface; other site 192222002131 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 8.5e-13 192222002132 5 probable transmembrane helices predicted for Cj0468 by TMHMM2.0 at aa 20-42, 55-77, 87-109, 151-171 and 186-208 192222002133 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign 192222002134 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 192222002135 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 192222002136 Walker A/P-loop; other site 192222002137 ATP binding site [chemical binding]; other site 192222002138 Q-loop/lid; other site 192222002139 ABC transporter signature motif; other site 192222002140 Walker B; other site 192222002141 D-loop; other site 192222002142 H-loop/switch region; other site 192222002143 HMMPfam hit to PF00005, ABC transporter, score 1.7e-65 192222002144 PS00017 ATP/GTP-binding site motif A (P-loop) 192222002145 PS00211 ABC transporters family signature 192222002146 elongation factor Tu; Reviewed; Region: PRK00049 192222002147 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 192222002148 G1 box; other site 192222002149 GEF interaction site [polypeptide binding]; other site 192222002150 GTP/Mg2+ binding site [chemical binding]; other site 192222002151 Switch I region; other site 192222002152 G2 box; other site 192222002153 G3 box; other site 192222002154 Switch II region; other site 192222002155 G4 box; other site 192222002156 G5 box; other site 192222002157 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 192222002158 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 192222002159 Antibiotic Binding Site [chemical binding]; other site 192222002160 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 3.9e-98 192222002161 PS00017 ATP/GTP-binding site motif A (P-loop) 192222002162 PS00301 GTP-binding elongation factors signature 192222002163 HMMPfam hit to PF03144, Elongation factor Tu domain, score 3.6e-25 192222002164 HMMPfam hit to PF03143, Elongation factor Tu C-terminal domain, score 1.4e-59 192222002165 PS00017 ATP/GTP-binding site motif A (P-loop) 192222002166 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 192222002167 HMMPfam hit to PF00471, Ribosomal protein L33,score 3.3e-21 192222002168 PS00582 Ribosomal protein L33 signature 192222002169 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 192222002170 HMMPfam hit to PF00584, SecE/Sec61-gamma subunits of protein translo, score 4.9e-09 192222002171 1 probable transmembrane helix predicted for Cj0472 by TMHMM2.0 at aa 29-51 192222002172 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 192222002173 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 192222002174 putative homodimer interface [polypeptide binding]; other site 192222002175 KOW motif; Region: KOW; cl00354 192222002176 HMMPfam hit to PF02357, Transcription termination factor nusG, score 2e-14 192222002177 HMMPfam hit to PF00467, KOW motif, score 2.4e-07 192222002178 PS01014 Transcription termination factor nusG signature 192222002179 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 192222002180 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 192222002181 23S rRNA interface [nucleotide binding]; other site 192222002182 L7/L12 interface [polypeptide binding]; other site 192222002183 putative thiostrepton binding site; other site 192222002184 L25 interface [polypeptide binding]; other site 192222002185 HMMPfam hit to PF03946, Ribosomal protein L11,N-terminal dom, score 1.4e-33 192222002186 HMMPfam hit to PF00298, Ribosomal protein L11, RNA binding do, score 9.7e-27 192222002187 PS00359 Ribosomal protein L11 signature 192222002188 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 192222002189 mRNA/rRNA interface [nucleotide binding]; other site 192222002190 HMMPfam hit to PF00687, Ribosomal protein L1p/L10e family, score 3.8e-119 192222002191 PS01199 Ribosomal protein L1 signature 192222002192 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 192222002193 23S rRNA interface [nucleotide binding]; other site 192222002194 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 192222002195 HMMPfam hit to PF00466, Ribosomal protein L10,score 9.6e-20 192222002196 PS00017 ATP/GTP-binding site motif A (P-loop) 192222002197 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 192222002198 L11 interface [polypeptide binding]; other site 192222002199 putative EF-Tu interaction site [polypeptide binding]; other site 192222002200 putative EF-G interaction site [polypeptide binding]; other site 192222002201 HMMPfam hit to PF00542, Ribosomal protein L7/L12 C-terminal dom, score 2.3e-38 192222002202 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 192222002203 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 192222002204 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 192222002205 RPB11 interaction site [polypeptide binding]; other site 192222002206 RPB12 interaction site [polypeptide binding]; other site 192222002207 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 192222002208 RPB3 interaction site [polypeptide binding]; other site 192222002209 RPB1 interaction site [polypeptide binding]; other site 192222002210 RPB11 interaction site [polypeptide binding]; other site 192222002211 RPB10 interaction site [polypeptide binding]; other site 192222002212 HMMPfam hit to PF04563, RNA polymerase beta subunit, score 3e-05 192222002213 HMMPfam hit to PF04561, RNA polymerase Rpb2,domain, score 1.8e-11 192222002214 HMMPfam hit to PF04565, RNA polymerase Rpb2,domain, score 3.9e-44 192222002215 HMMPfam hit to PF00562, RNA polymerase Rpb2,domain, score 1.4e-148 192222002216 PS01166 RNA polymerases beta chain signature 192222002217 HMMPfam hit to PF04560, RNA polymerase Rpb2,domain, score 3.7e-46 192222002218 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 192222002219 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 192222002220 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 192222002221 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 192222002222 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 192222002223 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 192222002224 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 192222002225 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 192222002226 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Provisional; Region: PRK14844 192222002227 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 192222002228 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 192222002229 DNA binding site [nucleotide binding] 192222002230 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 192222002231 HMMPfam hit to PF04997, RNA polymerase Rpb1,domain, score 3.7e-127 192222002232 HMMPfam hit to PF00623, RNA polymerase Rpb1,domain, score 6.6e-84 192222002233 HMMPfam hit to PF04983, RNA polymerase Rpb1,domain, score 3.5e-44 192222002234 HMMPfam hit to PF05000, RNA polymerase Rpb1,domain, score 3.6e-33 192222002235 HMMPfam hit to PF04998, RNA polymerase Rpb1,domain, score 6.7e-68 192222002236 Transcriptional regulator [Transcription]; Region: IclR; COG1414 192222002237 Helix-turn-helix domains; Region: HTH; cl00088 192222002238 HMMPfam hit to PF01614, Bacterial transcriptional regulator, score 8.6e-16 192222002239 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 192222002240 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 192222002241 inhibitor site; inhibition site 192222002242 active site 192222002243 dimer interface [polypeptide binding]; other site 192222002244 catalytic residue [active] 192222002245 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase family, score 3.8e-30 192222002246 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 192222002247 HMMPfam hit to PF04292, D-galactarate dehydratase / Altronate hydrol, score 1.1e-47 192222002248 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 192222002249 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 192222002250 HMMPfam hit to PF04295, D-galactarate dehydratase / Altronate hydrol, score 3.8e-251 192222002251 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222002252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 192222002253 putative substrate translocation pore; other site 192222002254 11 probable transmembrane helices predicted for Cj0484 by TMHMM2.0 at aa 20-41, 56-78, 85-104, 114-136,145-167, 177-199, 242-264, 279-301, 308-330, 334-356 and 365-387 192222002255 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 6.8e-47 192222002256 short chain dehydrogenase; Provisional; Region: PRK08628 192222002257 classical (c) SDRs; Region: SDR_c; cd05233 192222002258 NAD(P) binding site [chemical binding]; other site 192222002259 active site 192222002260 HMMPfam hit to PF00106, short chain dehydrogenase,score 2.8e-49 192222002261 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 192222002262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 192222002263 12 probable transmembrane helices predicted for Cj0486 by TMHMM2.0 at aa 9-31, 46-68, 75-97, 102-124,144-163, 183-205, 236-258, 273-290, 303-320, 325-347,359-381 and 385-407 192222002264 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.2e-30 192222002265 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222002266 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 192222002267 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 192222002268 HMMPfam hit to PF04909, Amidohydrolase, score 3.4e-29 192222002269 Domain of unknown function (DUF718); Region: DUF718; cl01281 192222002270 HMMPfam hit to PF05336, Protein of unknown function (DUF718), score 3e-63 192222002271 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 192222002272 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 192222002273 NAD binding site [chemical binding]; other site 192222002274 catalytic residues [active] 192222002275 substrate binding site [chemical binding]; other site 192222002276 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 9.2e-130 192222002277 1 probable transmembrane helix predicted for Cj0490 by TMHMM2.0 at aa 46-68 192222002278 PS00687 Aldehyde dehydrogenases glutamic acid active site 192222002279 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 192222002280 S17 interaction site [polypeptide binding]; other site 192222002281 S8 interaction site; other site 192222002282 16S rRNA interaction site [nucleotide binding]; other site 192222002283 streptomycin interaction site [chemical binding]; other site 192222002284 23S rRNA interaction site [nucleotide binding]; other site 192222002285 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 192222002286 HMMPfam hit to PF00164, Ribosomal protein S12,score 4.3e-73 192222002287 PS00055 Ribosomal protein S12 signature 192222002288 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 192222002289 HMMPfam hit to PF00177, Ribosomal protein S7p/S5e,score 4.1e-74 192222002290 PS00052 Ribosomal protein S7 signature 192222002291 elongation factor G; Reviewed; Region: PRK00007 192222002292 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 192222002293 G1 box; other site 192222002294 putative GEF interaction site [polypeptide binding]; other site 192222002295 GTP/Mg2+ binding site [chemical binding]; other site 192222002296 Switch I region; other site 192222002297 G2 box; other site 192222002298 G3 box; other site 192222002299 Switch II region; other site 192222002300 G4 box; other site 192222002301 G5 box; other site 192222002302 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 192222002303 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 192222002304 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 192222002305 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 5.8e-118 192222002306 PS00017 ATP/GTP-binding site motif A (P-loop) 192222002307 PS00301 GTP-binding elongation factors signature 192222002308 HMMPfam hit to PF03144, Elongation factor Tu domain, score 1.2e-17 192222002309 HMMPfam hit to PF03764, Elongation factor G, domain IV, score 1.6e-75 192222002310 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 1.1e-53 192222002311 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 192222002312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 192222002313 S-adenosylmethionine binding site [chemical binding]; other site 192222002314 PS00092 N-6 Adenine-specific DNA methylases signature 192222002315 Flagellin N-methylase; Region: FliB; cl00497 192222002316 HMMPfam hit to PF03692, Uncharacterised protein family (UPF0153), score 1.4e-32 192222002317 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 192222002318 1 probable transmembrane helix predicted for Cj0497 by TMHMM2.0 at aa 5-27 192222002319 PS00294 Prenyl group binding site (CAAX box) 192222002320 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222002321 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 2.3 192222002322 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 192222002323 active site 192222002324 substrate (anthranilate) binding pocket [chemical binding]; other site 192222002325 product (indole) binding pocket [chemical binding]; other site 192222002326 ribulose/triose binding site [chemical binding]; other site 192222002327 phosphate binding site [ion binding]; other site 192222002328 HMMPfam hit to PF00218, Indole-3-glycerol phosphate synthase, score 2.7e-106 192222002329 PS00614 Indole-3-glycerol phosphate synthase signature 192222002330 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 192222002331 nucleotide binding site/active site [active] 192222002332 HIT family signature motif; other site 192222002333 catalytic residue [active] 192222002334 HMMPfam hit to PF01230, HIT domain, score 7.1e-06 192222002335 Predicted ATPase [General function prediction only]; Region: COG2603 192222002336 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 192222002337 active site residue [active] 192222002338 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222002339 active site 192222002340 PS00017 ATP/GTP-binding site motif A (P-loop) 192222002341 Original (2000) note: Cj0501, probable ammonium transporter pseudogene; len: 1114 bp; similar to amny e.g. NRGA_BACSU probable ammonium transporter (404 aa).There is at least one frameshift and one stop codon in this pseudogene. No Hp match. Contains PS01219 Ammonium transporters signature and Pfam match to entry PF00909 Ammonium_transp, Ammonium Transporter Family, score 29.60,E-value 7.1e-12; Updated (2006) note: Nine probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterised within Escherichia coli and Bacillus subtilis with acceptable identity scores. Thus, not added to product function. Coding sequence has been updated to reflect the complete amino acid sequence for the encoded protein regardless of its expression. This will cause differences from the amino acid sequence of the previous annotation. Functional classification - Transport/binding proteins - Other; PMID:12023896, PMID:10931328, PMID:15361618,PMID:14600241 192222002342 9 probable transmembrane helices predicted for Cj0501 by TMHMM2.0 at aa 5-27, 40-62, 94-116, 121-143,158-180, 193-212, 222-244, 274-296 and 355-377 192222002343 HMMPfam hit to PF00909, Ammonium Transporter Family, score 7.1e-121 192222002344 ferrochelatase; Reviewed; Region: hemH; PRK00035 192222002345 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 192222002346 C-terminal domain interface [polypeptide binding]; other site 192222002347 active site 192222002348 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 192222002349 active site 192222002350 N-terminal domain interface [polypeptide binding]; other site 192222002351 HMMPfam hit to PF00762, Ferrochelatase, score 3e-72 192222002352 PS00534 Ferrochelatase signature 192222002353 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 192222002354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222002355 HMMPfam hit to PF01408, Oxidoreductase family,NAD-binding Rossm, score 1.2e-20 192222002356 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 192222002357 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 192222002358 inhibitor-cofactor binding pocket; inhibition site 192222002359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222002360 catalytic residue [active] 192222002361 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 4.8e-130 192222002362 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 192222002363 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 192222002364 motif 1; other site 192222002365 active site 192222002366 motif 2; other site 192222002367 motif 3; other site 192222002368 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 192222002369 DHHA1 domain; Region: DHHA1; pfam02272 192222002370 HMMPfam hit to PF01411, tRNA synthetases class II (A), score 0 192222002371 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 192222002372 HMMPfam hit to PF02272, DHHA1 domain, score 1.6e-16 192222002373 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 192222002374 Maf-like protein; Region: Maf; pfam02545 192222002375 active site 192222002376 dimer interface [polypeptide binding]; other site 192222002377 HMMPfam hit to PF02545, Maf-like protein, score 6e-22 192222002378 Transglycosylase; Region: Transgly; cl07896 192222002379 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 192222002380 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 192222002381 1 probable transmembrane helix predicted for Cj0508 by TMHMM2.0 at aa 7-29 192222002382 HMMPfam hit to PF00912, Transglycosylase, score 2.2e-82 192222002383 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 1.1e-33 192222002384 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 192222002385 Clp amino terminal domain; Region: Clp_N; pfam02861 192222002386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 192222002387 Walker A motif; other site 192222002388 ATP binding site [chemical binding]; other site 192222002389 Walker B motif; other site 192222002390 arginine finger; other site 192222002391 Protein of unknown function (DUF972); Region: DUF972; pfam06156 192222002392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 192222002393 Walker A motif; other site 192222002394 ATP binding site [chemical binding]; other site 192222002395 Walker B motif; other site 192222002396 arginine finger; other site 192222002397 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 192222002398 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 5.2e-05 192222002399 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 3.2e-102 192222002400 PS00871 Chaperonins clpA/B signature 2 192222002401 PS00017 ATP/GTP-binding site motif A (P-loop) 192222002402 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 7.4e-21 192222002403 PS00870 Chaperonins clpA/B signature 1 192222002404 PS00017 ATP/GTP-binding site motif A (P-loop) 192222002405 HMMPfam hit to PF02861, Clp amino terminal domain,score 0.0056 192222002406 HMMPfam hit to PF02861, Clp amino terminal domain,score 6.5e-11 192222002407 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 192222002408 putative homodimer interface [polypeptide binding]; other site 192222002409 putative homotetramer interface [polypeptide binding]; other site 192222002410 putative metal binding site [ion binding]; other site 192222002411 putative homodimer-homodimer interface [polypeptide binding]; other site 192222002412 putative allosteric switch controlling residues; other site 192222002413 HMMPfam hit to PF02583, Uncharacterised BCR,COG1937, score 2.1e-17 192222002414 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 192222002415 C-terminal peptidase (prc); Region: prc; TIGR00225 192222002416 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 192222002417 protein binding site [polypeptide binding]; other site 192222002418 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 192222002419 Catalytic dyad [active] 192222002420 1 probable transmembrane helix predicted for Cj0511 by TMHMM2.0 at aa 12-34 192222002421 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 1.9e-11 192222002422 HMMPfam hit to PF03572, Peptidase family S41, score 7.9e-76 192222002423 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 192222002424 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 192222002425 ATP binding site [chemical binding]; other site 192222002426 active site 192222002427 substrate binding site [chemical binding]; other site 192222002428 HMMPfam hit to PF01259, SAICAR synthetase, score 1.6e-90 192222002429 PS01057 SAICAR synthetase signature 1 192222002430 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 192222002431 HMMPfam hit to PF02700,Phosphoribosylformylglycinamidine (FGAM) syn, score 1.3e-31 192222002432 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 192222002433 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 192222002434 putative active site [active] 192222002435 catalytic triad [active] 192222002436 HMMPfam hit to PF07685, CobB/CobQ-like glutamine amidotransferase do, score 0.002 192222002437 1 probable transmembrane helix predicted for Cj0515 by TMHMM2.0 at aa 311-333 192222002438 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 192222002439 putative acyl-acceptor binding pocket; other site 192222002440 PS00989 Clathrin adaptor complexes small chain signature 192222002441 1 probable transmembrane helix predicted for Cj0516 by TMHMM2.0 at aa 10-29 192222002442 HMMPfam hit to PF01553, Acyltransferase, score 1.4e-22 192222002443 CrcB-like protein; Region: CRCB; cl09114 192222002444 HMMPfam hit to PF02537, CrcB-like protein, score 4e-29 192222002445 4 probable transmembrane helices predicted for Cj0517 by TMHMM2.0 at aa 5-23, 33-55, 62-84 and 99-121 192222002446 heat shock protein 90; Provisional; Region: PRK05218 192222002447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 192222002448 PS00298 Heat shock hsp90 proteins family signature 192222002449 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 6.5e-13 192222002450 HMMPfam hit to PF00183, Hsp90 protein, score 2.7e-29 192222002451 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 192222002452 active site residue [active] 192222002453 1 probable transmembrane helix predicted for Cj0520 by TMHMM2.0 at aa 2-20 192222002454 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 192222002455 HMMPfam hit to PF02690, Na+/Pi-cotransporter, score 2.1e-06 192222002456 3 probable transmembrane helices predicted for Cj0522 by TMHMM2.0 at aa 57-79, 89-111 and 118-140 192222002457 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 192222002458 3 probable transmembrane helices predicted for Cj0523 by TMHMM2.0 at aa 5-27, 31-53 and 65-87 192222002459 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 192222002460 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 192222002461 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 192222002462 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 2e-66 192222002463 PS00017 ATP/GTP-binding site motif A (P-loop) 192222002464 HMMPfam hit to PF03717, Penicillin-binding Protein dimerisatio, score 6.6e-30 192222002465 1 probable transmembrane helix predicted for Cj0525c by TMHMM2.0 at aa 12-34 192222002466 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 192222002467 HMMPfam hit to PF02049, Flagellar hook-basal body complex protein Fl, score 4.3e-22 192222002468 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 192222002469 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 192222002470 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 192222002471 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 2.2e-06 192222002472 HMMPfam hit to PF00460, Flagella basal body rod protein, score 8.5e-07 192222002473 PS00588 Flagella basal body rod proteins signature 192222002474 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 192222002475 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 192222002476 YceG-like family; Region: YceG; pfam02618 192222002477 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 192222002478 dimerization interface [polypeptide binding]; other site 192222002479 HMMPfam hit to PF02618, Aminodeoxychorismate lyase,score 4.8e-109 192222002480 1 probable transmembrane helix predicted for Cj0529c by TMHMM2.0 at aa 21-43 192222002481 Protein of unknown function; Region: DUF3971; pfam13116 192222002482 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 192222002483 AsmA-like C-terminal region; Region: AsmA_2; cl15864 192222002484 1 probable transmembrane helix predicted for Cj0530 by TMHMM2.0 at aa 7-29 192222002485 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 192222002486 HMMPfam hit to PF03971, Monomeric isocitrate dehydrogenase, score 0 192222002487 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 192222002488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222002489 NAD(P) binding site [chemical binding]; other site 192222002490 LDH/MDH dimer interface [polypeptide binding]; other site 192222002491 substrate binding site [chemical binding]; other site 192222002492 HMMPfam hit to PF00056, lactate/malate dehydrogenase, NAD binding do, score 2.4e-28 192222002493 HMMPfam hit to PF02866, lactate/malate dehydrogenase, alpha/beta C-t, score 4.6e-09 192222002494 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 192222002495 ATP-grasp domain; Region: ATP-grasp_4; cl03087 192222002496 CoA-ligase; Region: Ligase_CoA; cl02894 192222002497 HMMPfam hit to PF02222, ATP-grasp domain, score 5e-19 192222002498 HMMPfam hit to PF00549, CoA-ligase, score 1.4e-59 192222002499 PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3 192222002500 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 192222002501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222002502 CoA-ligase; Region: Ligase_CoA; cl02894 192222002503 HMMPfam hit to PF02629, CoA binding domain, score 2.2e-59 192222002504 HMMPfam hit to PF00549, CoA-ligase, score 2.3e-39 192222002505 PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1 192222002506 PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site 192222002507 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 192222002508 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 192222002509 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 2.5e-05 192222002510 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222002511 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 5.8e-05 192222002512 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222002513 2-oxoglutarate-acceptor oxidoreductase subunit OorA; Reviewed; Region: oorA; PRK09627 192222002514 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 192222002515 dimer interface [polypeptide binding]; other site 192222002516 PYR/PP interface [polypeptide binding]; other site 192222002517 TPP binding site [chemical binding]; other site 192222002518 substrate binding site [chemical binding]; other site 192222002519 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 192222002520 HMMPfam hit to PF01855, Pyruvate flavodoxin/ferredoxin oxidoreductas, score 5e-93 192222002521 2-oxoglutarate-acceptor oxidoreductase subunit OorB; Reviewed; Region: oorB; PRK09628 192222002522 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 192222002523 TPP-binding site [chemical binding]; other site 192222002524 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-termina, score 3.8e-87 192222002525 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 192222002526 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 192222002527 HMMPfam hit to PF01558, Pyruvate ferredoxin/flavodoxin oxidoreductas, score 3.8e-35 192222002528 Domain of unknown function (DUF2018); Region: DUF2018; pfam09442 192222002529 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 192222002530 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 192222002531 substrate binding pocket [chemical binding]; other site 192222002532 chain length determination region; other site 192222002533 substrate-Mg2+ binding site; other site 192222002534 catalytic residues [active] 192222002535 aspartate-rich region 1; other site 192222002536 active site lid residues [active] 192222002537 aspartate-rich region 2; other site 192222002538 HMMPfam hit to PF00348, Polyprenyl synthetase,score 1.4e-43 192222002539 PS00723 Polyprenyl synthetases signature 1 192222002540 PS00444 Polyprenyl synthetases signature 2 192222002541 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 192222002542 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 192222002543 tRNA; other site 192222002544 putative tRNA binding site [nucleotide binding]; other site 192222002545 putative NADP binding site [chemical binding]; other site 192222002546 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 192222002547 HMMPfam hit to PF05201, Glutamyl-tRNAGlu reductase,N-terminal, score 4.3e-44 192222002548 HMMPfam hit to PF05200, Glutamyl-tRNAGlu reductase,NAD(P) bin, score 2e-66 192222002549 HMMPfam hit to PF00745, Glutamyl-tRNAGlu reductase,dimerisati, score 2.9e-30 192222002550 prolyl-tRNA synthetase; Provisional; Region: PRK09194 192222002551 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 192222002552 dimer interface [polypeptide binding]; other site 192222002553 motif 1; other site 192222002554 active site 192222002555 motif 2; other site 192222002556 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 192222002557 putative deacylase active site [active] 192222002558 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 192222002559 active site 192222002560 motif 3; other site 192222002561 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 192222002562 anticodon binding site; other site 192222002563 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 6.1e-53 192222002564 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 192222002565 HMMPfam hit to PF04073, YbaK / prolyl-tRNA synthetases associa, score 4.8e-06 192222002566 HMMPfam hit to PF03129, Anticodon binding domain,score 7.4e-20 192222002567 3 probable transmembrane helices predicted for Cj0544 by TMHMM2.0 at aa 10-28, 30-49 and 69-100 192222002568 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 192222002569 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 192222002570 domain interfaces; other site 192222002571 active site 192222002572 HMMPfam hit to PF01379, Porphobilinogen deaminase,dipyrometh, score 5.7e-107 192222002573 HMMPfam hit to PF03900, Porphobilinogen deaminase,C-terminal, score 7.3e-15 192222002574 PS00533 Porphobilinogen deaminase cofactor-binding site 192222002575 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 192222002576 HMMPfam hit to PF01977,3-octaprenyl-4-hydroxybenzoate carboxy-lyase, score 4.7e-139 192222002577 FlaG protein; Region: FlaG; cl00591 192222002578 HMMPfam hit to PF03646, FlaG protein, score 4.7e-42 192222002579 flagellar capping protein; Provisional; Region: PRK12765 192222002580 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 192222002581 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 192222002582 HMMPfam hit to PF02465, Flagellar hook-associated protein, score 2.3e-33 192222002583 HMMPfam hit to PF07196, Flagellin hook IN motif,score 2.1e-10 192222002584 HMMPfam hit to PF07195, Flagellar hook-associated protein, score 4e-75 192222002585 Flagellar protein FliS; Region: FliS; cl00654 192222002586 HMMPfam hit to PF02561, Flagellar protein FliS,score 7.5e-35 192222002587 elongation factor P; Validated; Region: PRK00529 192222002588 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 192222002589 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 192222002590 RNA binding site [nucleotide binding]; other site 192222002591 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 192222002592 RNA binding site [nucleotide binding]; other site 192222002593 HMMPfam hit to PF01132, Elongation factor P (EF-P),score 1.7e-109 192222002594 Protein of unknown function (DUF969); Region: DUF969; cl01573 192222002595 HMMPfam hit to PF06149, Protein of unknown function (DUF969), score 3.4e-157 192222002596 4 probable transmembrane helices predicted for Cj0552 by TMHMM2.0 at aa 20-42, 52-71, 99-121 and 192-214 192222002597 Protein of unknown function (DUF979); Region: DUF979; cl01572 192222002598 HMMPfam hit to PF06166, Protein of unknown function (DUF979), score 4.2e-214 192222002599 9 probable transmembrane helices predicted for Cj0553 by TMHMM2.0 at aa 6-25, 46-68, 100-122, 129-151,166-188, 201-223, 228-245, 252-274 and 294-315 192222002600 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222002601 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222002602 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 192222002603 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 192222002604 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 192222002605 HMMPfam hit to PF07158, Dicarboxylate carrier protein MatC N-terminu, score 5e-36 192222002606 11 probable transmembrane helices predicted for Cj0555 by TMHMM2.0 at aa 2-20, 24-41, 48-70, 94-116,137-159, 179-201, 222-244, 259-276, 281-303, 323-345 and 407-429 192222002607 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222002608 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 192222002609 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 192222002610 active site 192222002611 HMMPfam hit to PF04909, Amidohydrolase, score 9.5e-37 192222002612 Predicted membrane protein [Function unknown]; Region: COG1289 192222002613 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 192222002614 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222002615 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 192222002616 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 192222002617 putative catalytic cysteine [active] 192222002618 PS01223 Gamma-glutamyl phosphate reductase signature 192222002619 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 192222002620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222002621 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 192222002622 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreducta, score 1.7e-25 192222002623 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222002624 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 192222002625 MatE; Region: MatE; cl10513 192222002626 MatE; Region: MatE; cl10513 192222002627 12 probable transmembrane helices predicted for Cj0560 by TMHMM2.0 at aa 13-34, 49-71, 91-113, 135-157,166-188, 192-214, 235-257, 267-289, 310-332, 352-374,387-409 and 414-433 192222002628 HMMPfam hit to PF01554, MatE, score 9.6e-25 192222002629 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222002630 PS00225 Crystallins beta and gamma 'Greek key' motif signature 192222002631 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222002632 Protein of unknown function (DUF2860); Region: DUF2860; pfam11059 192222002633 replicative DNA helicase; Provisional; Region: PRK08506 192222002634 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 192222002635 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 192222002636 Walker A motif; other site 192222002637 ATP binding site [chemical binding]; other site 192222002638 Walker B motif; other site 192222002639 DNA binding loops [nucleotide binding] 192222002640 HMMPfam hit to PF00772, DnaB-like helicase N terminal domain, score 1.2e-24 192222002641 HMMPfam hit to PF03796, DnaB-like helicase C terminal domain, score 5.7e-117 192222002642 PS00017 ATP/GTP-binding site motif A (P-loop) 192222002643 2 probable transmembrane helices predicted for Cj0564 by TMHMM2.0 at aa 7-38 and 43-65 192222002644 Original (2000) note: Cj0565, probable pseudogene,len: 725 bp; similar to three consecutive genes in Hp; HP1587, HP1588 and HP1589; Updated (2006) note: Pfam domain PF03667 Uncharacterised protein family (UPF0174) identified within CDS. Conserved introduced to product function as motif identified. Coding sequence has been updated to reflect the complete amino acid sequence for the encoded protein regardless of its expression. This will cause differences from the amino acid sequence of the previous annotation. Functional classification - Conserved hypothetical proteins 192222002645 HMMPfam hit to PF03667, Uncharacterised protein family (UPF0174), score 3.1e-51 192222002646 1 probable transmembrane helix predicted for Cj0568 by TMHMM2.0 at aa 30-49 192222002647 PS00017 ATP/GTP-binding site motif A (P-loop) 192222002648 Predicted transcriptional regulator [Transcription]; Region: COG2378 192222002649 Helix-turn-helix domains; Region: HTH; cl00088 192222002650 WYL domain; Region: WYL; cl14852 192222002651 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 192222002652 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 192222002653 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 192222002654 PS00430 TonB-dependent receptor proteins signature 1 192222002655 HMMPfam hit to PF00926, 3,4-dihydroxy-2-butanone 4-phosphate sy, score 6.2e-114 192222002656 GatB domain; Region: GatB_Yqey; cl11497 192222002657 HMMPfam hit to PF02637, GatB/Yqey domain, score 2.7e-29 192222002658 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08527 192222002659 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 192222002660 PYR/PP interface [polypeptide binding]; other site 192222002661 dimer interface [polypeptide binding]; other site 192222002662 TPP binding site [chemical binding]; other site 192222002663 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 192222002664 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 192222002665 TPP-binding site [chemical binding]; other site 192222002666 dimer interface [polypeptide binding]; other site 192222002667 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 2.2e-89 192222002668 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 2.4e-62 192222002669 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 192222002670 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 192222002671 putative valine binding site [chemical binding]; other site 192222002672 dimer interface [polypeptide binding]; other site 192222002673 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 192222002674 HMMPfam hit to PF01842, ACT domain, score 1.2e-13 192222002675 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 192222002676 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 192222002677 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 192222002678 trimer interface [polypeptide binding]; other site 192222002679 active site 192222002680 UDP-GlcNAc binding site [chemical binding]; other site 192222002681 lipid binding site [chemical binding]; lipid-binding site 192222002682 HMMPfam hit to PF04613,UDP-3-O-[3-hydroxymyristoyl] glucosamine N-a, score 1e-36 192222002683 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 76 192222002684 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.0021 192222002685 PS00101 Hexapeptide-repeat containing-transferases signature 192222002686 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.0029 192222002687 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.12 192222002688 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 17 192222002689 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 7.4 192222002690 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 4 192222002691 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 93 192222002692 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 192222002693 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 192222002694 HMMPfam hit to PF02547, Queuosine biosynthesis protein, score 1e-85 192222002695 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 192222002696 HMMPfam hit to PF00902, Sec-independent protein translocase, score 1.1e-85 192222002697 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222002698 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 192222002699 HMMPfam hit to PF02416, mttA/Hcf106 family, score 8.2e-05 192222002700 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 192222002701 HMMPfam hit to PF06969, HemN C-terminal region,score 4.5e-09 192222002702 HMMPfam hit to PF04055, Radical SAM superfamily,score 3.4e-23 192222002703 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 192222002704 putative active site [active] 192222002705 Ap4A binding site [chemical binding]; other site 192222002706 nudix motif; other site 192222002707 putative metal binding site [ion binding]; other site 192222002708 HMMPfam hit to PF00293, NUDIX domain, score 4.9e-17 192222002709 PS00893 mutT domain signature 192222002710 aspartate kinase; Reviewed; Region: PRK06635 192222002711 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 192222002712 putative nucleotide binding site [chemical binding]; other site 192222002713 putative catalytic residues [active] 192222002714 putative Mg ion binding site [ion binding]; other site 192222002715 putative aspartate binding site [chemical binding]; other site 192222002716 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 192222002717 putative allosteric regulatory site; other site 192222002718 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 192222002719 HMMPfam hit to PF00696, Amino acid kinase family,score 3.7e-77 192222002720 PS00324 Aspartokinase signature 192222002721 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 192222002722 HMMPfam hit to PF01842, ACT domain, score 7.1e-09 192222002723 HMMPfam hit to PF01842, ACT domain, score 2.5e-08 192222002724 DNA replication regulator; Region: HobA; pfam12163 192222002725 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222002726 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 192222002727 dihydropteroate synthase; Region: DHPS; TIGR01496 192222002728 substrate binding pocket [chemical binding]; other site 192222002729 dimer interface [polypeptide binding]; other site 192222002730 inhibitor binding site; inhibition site 192222002731 HMMPfam hit to PF00809, Pterin binding enzyme,score 1.2e-79 192222002732 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 192222002733 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 192222002734 nucleotide binding pocket [chemical binding]; other site 192222002735 K-X-D-G motif; other site 192222002736 catalytic site [active] 192222002737 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 192222002738 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 192222002739 Dimer interface [polypeptide binding]; other site 192222002740 BRCT sequence motif; other site 192222002741 HMMPfam hit to PF01653, NAD-dependent DNA ligase adenylation, score 3.7e-121 192222002742 HMMPfam hit to PF03120, NAD-dependent DNA ligase OB-fold doma, score 3.9e-41 192222002743 PS01056 NAD-dependent DNA ligase signature 2 192222002744 HMMPfam hit to PF00533, BRCA1 C Terminus (BRCT) domain, score 1e-15 192222002745 8 probable transmembrane helices predicted for Cj0587 by TMHMM2.0 at aa 7-24, 28-50, 74-96, 101-123,135-157, 182-204, 211-233 and 237-255 192222002746 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 192222002747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 192222002748 HMMPfam hit to PF01479, S4 domain, score 0.013 192222002749 HMMPfam hit to PF01728, FtsJ-like methyltransferase, score 3e-06 192222002750 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 192222002751 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 192222002752 active site 192222002753 nucleotide binding site [chemical binding]; other site 192222002754 HIGH motif; other site 192222002755 KMSKS motif; other site 192222002756 Riboflavin kinase; Region: Flavokinase; cl03312 192222002757 HMMPfam hit to PF06574, Riboflavin kinase (Flavokinase), score 1.5e-10 192222002758 HMMPfam hit to PF01687, Riboflavin kinase / FAD synthetase, score 1.2e-24 192222002759 Methyltransferase domain; Region: Methyltransf_31; pfam13847 192222002760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 192222002761 S-adenosylmethionine binding site [chemical binding]; other site 192222002762 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222002763 Predicted membrane protein [Function unknown]; Region: COG2860 192222002764 UPF0126 domain; Region: UPF0126; pfam03458 192222002765 UPF0126 domain; Region: UPF0126; pfam03458 192222002766 HMMPfam hit to PF03458, UPF0126 domain, score 2.4e-34 192222002767 HMMPfam hit to PF03458, UPF0126 domain, score 6.7e-38 192222002768 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 192222002769 active site 192222002770 substrate binding site [chemical binding]; other site 192222002771 Mg2+ binding site [ion binding]; other site 192222002772 HMMPfam hit to PF01223, DNA/RNA non-specific endonuclease, score 5.7e-21 192222002773 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 192222002774 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 192222002775 minor groove reading motif; other site 192222002776 helix-hairpin-helix signature motif; other site 192222002777 substrate binding pocket [chemical binding]; other site 192222002778 active site 192222002779 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 192222002780 PS00764 Endonuclease III iron-sulfur binding region signature 192222002781 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 9.8e-20 192222002782 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 192222002783 PPIC-type PPIASE domain; Region: Rotamase; cl08278 192222002784 1 probable transmembrane helix predicted for Cj0596 by TMHMM2.0 at aa 5-27 192222002785 HMMPfam hit to PF00639, PPIC-type PPIASE domain,score 2.7e-30 192222002786 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature 192222002787 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 192222002788 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 192222002789 active site 192222002790 intersubunit interface [polypeptide binding]; other site 192222002791 zinc binding site [ion binding]; other site 192222002792 Na+ binding site [ion binding]; other site 192222002793 HMMPfam hit to PF01116, Fructose-bisphosphate aldolase class-II, score 9.3e-215 192222002794 PS00602 Fructose-bisphosphate aldolase class-II signature 1 192222002795 PS00806 Fructose-bisphosphate aldolase class-II signature 2 192222002796 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 192222002797 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 192222002798 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 192222002799 4 probable transmembrane helices predicted for Cj0598 by TMHMM2.0 at aa 21-43, 53-70, 129-151 and 173-195 192222002800 hypothetical protein; Validated; Region: PRK09039 192222002801 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 192222002802 ligand binding site [chemical binding]; other site 192222002803 1 probable transmembrane helix predicted for Cj0599 by TMHMM2.0 at aa 13-35 192222002804 HMMPfam hit to PF00691, OmpA family, score 2.1e-05 192222002805 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 192222002806 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 192222002807 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 192222002808 catalytic residue [active] 192222002809 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 192222002810 HMMPfam hit to PF00209, Sodium:neurotransmitter symporter family, score 1.2e-14 192222002811 PS00610 Sodium:neurotransmitter symporter family signature 1 192222002812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 192222002813 MOSC domain; Region: MOSC; pfam03473 192222002814 HMMPfam hit to PF03475, 3-alpha domain, score 2.7e-17 192222002815 HMMPfam hit to PF03473, MOSC domain, score 2.2e-44 192222002816 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 192222002817 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 192222002818 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 192222002819 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 192222002820 DsbD alpha interface [polypeptide binding]; other site 192222002821 catalytic residues [active] 192222002822 HMMPfam hit to PF02683, Cytochrome C biogenesis protein transmembran, score 1.2e-07 192222002823 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222002824 active site 192222002825 HMMPfam hit to PF03976, Domain of unknown function (DUF344), score 3.4e-171 192222002826 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 192222002827 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 192222002828 metal binding site [ion binding]; metal-binding site 192222002829 dimer interface [polypeptide binding]; other site 192222002830 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 1e-43 192222002831 PS00070 Aldehyde dehydrogenases cysteine active site 192222002832 macrolide transporter subunit MacA; Provisional; Region: PRK11578 192222002833 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 192222002834 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 192222002835 1 probable transmembrane helix predicted for Cj0606 by TMHMM2.0 at aa 5-24 192222002836 HMMPfam hit to PF00529, HlyD family secretion protein, score 0.00033 192222002837 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 192222002838 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 192222002839 Walker A/P-loop; other site 192222002840 ATP binding site [chemical binding]; other site 192222002841 Q-loop/lid; other site 192222002842 ABC transporter signature motif; other site 192222002843 Walker B; other site 192222002844 D-loop; other site 192222002845 H-loop/switch region; other site 192222002846 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 192222002847 FtsX-like permease family; Region: FtsX; cl15850 192222002848 HMMPfam hit to PF00005, ABC transporter, score 3.9e-54 192222002849 PS00017 ATP/GTP-binding site motif A (P-loop) 192222002850 PS00211 ABC transporters family signature 192222002851 4 probable transmembrane helices predicted for Cj0607 by TMHMM2.0 at aa 265-287, 516-538, 567-589 and 602-624 192222002852 PS00017 ATP/GTP-binding site motif A (P-loop) 192222002853 HMMPfam hit to PF02687, Predicted permease, score 2.4e-46 192222002854 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 192222002855 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222002856 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.2e-12 192222002857 HMMPfam hit to PF02321, Outer membrane efflux protein, score 7.5e-11 192222002858 PS00217 Sugar transport proteins signature 2 192222002859 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 192222002860 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 192222002861 active site 192222002862 oxyanion hole [active] 192222002863 catalytic triad [active] 192222002864 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 192222002865 active site 192222002866 catalytic triad [active] 192222002867 oxyanion hole [active] 192222002868 HMMPfam hit to PF04311, Protein of unknown function (DUF459), score 1.7e-184 192222002869 1 probable transmembrane helix predicted for Cj0610c by TMHMM2.0 at aa 7-29 192222002870 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 192222002871 HMMPfam hit to PF03062, MBOAT family, score 4.1e-80 192222002872 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 192222002873 Ferritin-like domain; Region: Ferritin; pfam00210 192222002874 ferroxidase diiron center [ion binding]; other site 192222002875 HMMPfam hit to PF00210, Ferritin-like domain, score 6.7e-50 192222002876 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 192222002877 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 192222002878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 192222002879 dimer interface [polypeptide binding]; other site 192222002880 conserved gate region; other site 192222002881 putative PBP binding loops; other site 192222002882 ABC-ATPase subunit interface; other site 192222002883 6 probable transmembrane helices predicted for Cj0614 by TMHMM2.0 at aa 9-31, 83-105, 118-140, 155-174,199-221 and 273-295 192222002884 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.6e-16 192222002885 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 192222002886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 192222002887 dimer interface [polypeptide binding]; other site 192222002888 conserved gate region; other site 192222002889 putative PBP binding loops; other site 192222002890 ABC-ATPase subunit interface; other site 192222002891 6 probable transmembrane helices predicted for Cj0615 by TMHMM2.0 at aa 21-43, 146-168, 188-210, 215-237,263-285 and 331-353 192222002892 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.9e-17 192222002893 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14269 192222002894 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 192222002895 Walker A/P-loop; other site 192222002896 ATP binding site [chemical binding]; other site 192222002897 Q-loop/lid; other site 192222002898 ABC transporter signature motif; other site 192222002899 Walker B; other site 192222002900 D-loop; other site 192222002901 H-loop/switch region; other site 192222002902 HMMPfam hit to PF00005, ABC transporter, score 3.2e-51 192222002903 PS00017 ATP/GTP-binding site motif A (P-loop) 192222002904 PS00211 ABC transporters family signature 192222002905 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 192222002906 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 192222002907 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 192222002908 MatE; Region: MatE; cl10513 192222002909 MatE; Region: MatE; cl10513 192222002910 12 probable transmembrane helices predicted for Cj0619 by TMHMM2.0 at aa 13-35, 50-69, 89-111, 126-148,155-177, 187-209, 229-251, 266-288, 309-328, 343-365,377-399 and 403-422 192222002911 HMMPfam hit to PF01554, MatE, score 3.7e-19 192222002912 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222002913 Protein of unknown function DUF45; Region: DUF45; cl00636 192222002914 HMMPfam hit to PF01863, Protein of unknown function DUF45, score 1.1e-18 192222002915 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 192222002916 Acylphosphatase; Region: Acylphosphatase; cl00551 192222002917 HypF finger; Region: zf-HYPF; pfam07503 192222002918 HypF finger; Region: zf-HYPF; pfam07503 192222002919 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 192222002920 HMMPfam hit to PF00708, Acylphosphatase, score 2.2e-07 192222002921 PS00150 Acylphosphatase signature 1 192222002922 HMMPfam hit to PF07503, HypF finger, score 2e-16 192222002923 HMMPfam hit to PF07503, HypF finger, score 3.2e-16 192222002924 HMMPfam hit to PF01300, yrdC domain, score 6.5e-52 192222002925 HMMPfam hit to PF00814, Glycoprotease family, score 2.3e-18 192222002926 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222002927 PS00028 Zinc finger, C2H2 type, domain 192222002928 HMMPfam hit to PF02492, CobW/HypB/UreG,nucleotide-binding domain, score 4e-67 192222002929 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222002930 HupF/HypC family; Region: HupF_HypC; cl00394 192222002931 HMMPfam hit to PF01455, HupF/HypC family, score 2e-26 192222002932 Hydrogenase formation hypA family; Region: HypD; cl12072 192222002933 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 192222002934 HMMPfam hit to PF01924, Hydrogenase formation hypA family, score 8.6e-204 192222002935 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 192222002936 dimerization interface [polypeptide binding]; other site 192222002937 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 192222002938 ATP binding site [chemical binding]; other site 192222002939 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 7.3e-21 192222002940 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 3.7e-36 192222002941 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 192222002942 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 192222002943 HMMPfam hit to PF01155, Hydrogenase expression/synthesis hypA family, score 3.3e-50 192222002944 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 192222002945 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222002946 HMMPfam hit to PF03797, Autotransporter beta-domain, score 5.9e-38 192222002947 DNA polymerase III subunit delta; Validated; Region: PRK08487 192222002948 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 192222002949 HMMPfam hit to PF06144, DNA polymerase III, delta subunit, score 0.0012 192222002950 Exoribonuclease R [Transcription]; Region: VacB; COG0557 192222002951 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 192222002952 RNB domain; Region: RNB; pfam00773 192222002953 PS01175 Ribonuclease II family signature 192222002954 HMMPfam hit to PF00773, RNB-like protein, score 1.9e-59 192222002955 ketol-acid reductoisomerase; Provisional; Region: PRK05479 192222002956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222002957 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 192222002958 HMMPfam hit to PF01450, Acetohydroxy acid isomeroreductase, catalyti, score 2e-84 192222002959 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 192222002960 NodB motif; other site 192222002961 putative active site [active] 192222002962 putative catalytic site [active] 192222002963 Zn binding site [ion binding]; other site 192222002964 1 probable transmembrane helix predicted for Cj0633 by TMHMM2.0 at aa 12-31 192222002965 HMMPfam hit to PF04748, Divergent polysaccharide deacetylase, score 1.4e-112 192222002966 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 192222002967 HMMPfam hit to PF02481, SMF family, score 2e-53 192222002968 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 192222002969 HMMPfam hit to PF03652, Uncharacterised protein family (UPF0081), score 1e-52 192222002970 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 192222002971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 192222002972 HMMPfam hit to PF01189, NOL1/NOP2/sun family, score 2.4e-30 192222002973 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 192222002974 HMMPfam hit to PF01625, Peptide methionine sulfoxide reductase, score 2.4e-66 192222002975 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 192222002976 dimer interface [polypeptide binding]; other site 192222002977 substrate binding site [chemical binding]; other site 192222002978 metal binding sites [ion binding]; metal-binding site 192222002979 HMMPfam hit to PF00719, Inorganic pyrophosphatase,score 2.4e-53 192222002980 PS00387 Inorganic pyrophosphatase signature 192222002981 adenylate kinase; Reviewed; Region: adk; PRK00279 192222002982 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 192222002983 AMP-binding site [chemical binding]; other site 192222002984 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 192222002985 HMMPfam hit to PF00406, Adenylate kinase, score 2.4e-40 192222002986 PS00113 Adenylate kinase signature 192222002987 PS00017 ATP/GTP-binding site motif A (P-loop) 192222002988 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 192222002989 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 192222002990 dimer interface [polypeptide binding]; other site 192222002991 anticodon binding site; other site 192222002992 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 192222002993 homodimer interface [polypeptide binding]; other site 192222002994 motif 1; other site 192222002995 active site 192222002996 motif 2; other site 192222002997 GAD domain; Region: GAD; pfam02938 192222002998 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 192222002999 active site 192222003000 motif 3; other site 192222003001 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 1.8e-24 192222003002 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 192222003003 HMMPfam hit to PF02938, GAD domain, score 1.9e-31 192222003004 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 192222003005 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 3.7e-26 192222003006 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 192222003007 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 192222003008 HMMPfam hit to PF01513, ATP-NAD kinase, score 4.4e-54 192222003009 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 192222003010 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222003011 Walker A/P-loop; other site 192222003012 ATP binding site [chemical binding]; other site 192222003013 Q-loop/lid; other site 192222003014 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 192222003015 ABC transporter signature motif; other site 192222003016 Walker B; other site 192222003017 D-loop; other site 192222003018 H-loop/switch region; other site 192222003019 PS00017 ATP/GTP-binding site motif A (P-loop) 192222003020 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 192222003021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 192222003022 active site 192222003023 phosphorylation site [posttranslational modification] 192222003024 intermolecular recognition site; other site 192222003025 dimerization interface [polypeptide binding]; other site 192222003026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 192222003027 active site 192222003028 phosphorylation site [posttranslational modification] 192222003029 intermolecular recognition site; other site 192222003030 dimerization interface [polypeptide binding]; other site 192222003031 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 192222003032 metal binding site [ion binding]; metal-binding site 192222003033 active site 192222003034 I-site; other site 192222003035 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.7e-05 192222003036 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.3e-07 192222003037 HMMPfam hit to PF00990, GGDEF domain, score 1.3e-23 192222003038 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 192222003039 active site 192222003040 HMMPfam hit to PF01026, TatD related DNase, score 1.2e-106 192222003041 PS01137 Uncharacterized protein family UPF0006 signature 1 192222003042 PS00225 Crystallins beta and gamma 'Greek key' motif signature 192222003043 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 192222003044 N-acetyl-D-glucosamine binding site [chemical binding]; other site 192222003045 catalytic residue [active] 192222003046 autolysin; Reviewed; Region: PRK06347 192222003047 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 192222003048 putative peptidoglycan binding site; other site 192222003049 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 1.5e-28 192222003050 HMMPfam hit to PF01476, LysM domain, score 1.7e-17 192222003051 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 192222003052 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 192222003053 Sporulation related domain; Region: SPOR; cl10051 192222003054 1 probable transmembrane helix predicted for Cj0646 by TMHMM2.0 at aa 7-29 192222003055 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222003056 HMMPfam hit to PF03330, Rare lipoprotein A (RlpA)-like double-psi be, score 1.9e-44 192222003057 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 192222003058 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 192222003059 active site 192222003060 motif I; other site 192222003061 motif II; other site 192222003062 1 probable transmembrane helix predicted for Cj0648 by TMHMM2.0 at aa 5-22 192222003063 OstA-like protein; Region: OstA; cl00844 192222003064 HMMPfam hit to PF03968, OstA-like protein, score 5.1e-61 192222003065 Predicted GTPase [General function prediction only]; Region: COG0218 192222003066 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 192222003067 G1 box; other site 192222003068 GTP/Mg2+ binding site [chemical binding]; other site 192222003069 Switch I region; other site 192222003070 G2 box; other site 192222003071 G3 box; other site 192222003072 Switch II region; other site 192222003073 G4 box; other site 192222003074 G5 box; other site 192222003075 HMMPfam hit to PF01926, GTPase of unknown function,score 2.6e-26 192222003076 PS00017 ATP/GTP-binding site motif A (P-loop) 192222003077 5 probable transmembrane helices predicted for Cj0651 by TMHMM2.0 at aa 12-29, 33-52, 65-96, 111-133 and 140-159 192222003078 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 192222003079 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 192222003080 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 192222003081 1 probable transmembrane helix predicted for Cj0652 by TMHMM2.0 at aa 5-24 192222003082 HMMPfam hit to PF03717, Penicillin-binding Protein dimerisatio, score 1.9e-53 192222003083 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 1.5e-64 192222003084 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 192222003085 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 192222003086 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 192222003087 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 192222003088 active site 192222003089 HMMPfam hit to PF00557, metallopeptidase family M24, score 3.5e-09 192222003090 Original (2000) note: Cj0654c, probable transmembrane transport protein pseudogene, len: 1433 bp; similar to members of the PTR2 family of transporters. No apparent Hp ortholog. Contains PS01023 PTR2 family proton/oligopeptide symporters signature 2; Updated (2006) note: Pfam domain PF00854 POT family identified within CDS. Also, twelve probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. No specific characterisation with acceptable identity score has been carried out yet. Thus, added to product function. Coding sequence has been updated to reflect the complete amino acid sequence for the encoded protein regardless of its expression. This will cause differences from the amino acid sequence of the previous annotation. Functional classification -Transport/binding proteins - Other 192222003091 HMMPfam hit to PF00854, POT family, score 8e-11 192222003092 1 probable transmembrane helix predicted for Cj0659c by TMHMM2.0 at aa 17-39 192222003093 1 probable transmembrane helix predicted for Cj0660c by TMHMM2.0 at aa 207-229 192222003094 GTPase Era; Reviewed; Region: era; PRK00089 192222003095 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 192222003096 G1 box; other site 192222003097 GTP/Mg2+ binding site [chemical binding]; other site 192222003098 Switch I region; other site 192222003099 G2 box; other site 192222003100 Switch II region; other site 192222003101 G3 box; other site 192222003102 G4 box; other site 192222003103 G5 box; other site 192222003104 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 192222003105 HMMPfam hit to PF07650, KH domain, score 1.1e-22 192222003106 HMMPfam hit to PF01926, GTPase of unknown function,score 1.5e-31 192222003107 PS00017 ATP/GTP-binding site motif A (P-loop) 192222003108 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 192222003109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 192222003110 Walker A motif; other site 192222003111 ATP binding site [chemical binding]; other site 192222003112 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222003113 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 192222003114 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.5e-12 192222003115 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 4.8e-44 192222003116 PS00017 ATP/GTP-binding site motif A (P-loop) 192222003117 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 192222003118 active site 192222003119 HslU subunit interaction site [polypeptide binding]; other site 192222003120 HMMPfam hit to PF00227, Proteasome A-type and B-type, score 1.2e-44 192222003121 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 192222003122 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 192222003123 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 192222003124 HMMPfam hit to PF03948, Ribosomal protein L9,C-terminal domai, score 3.7e-20 192222003125 HMMPfam hit to PF01281, Ribosomal protein L9,N-terminal domai, score 2.9e-21 192222003126 PS00651 Ribosomal protein L9 signature 192222003127 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 192222003128 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 192222003129 ANP binding site [chemical binding]; other site 192222003130 Substrate Binding Site II [chemical binding]; other site 192222003131 Substrate Binding Site I [chemical binding]; other site 192222003132 HMMPfam hit to PF00764, Arginosuccinate synthase,score 1.7e-193 192222003133 PS00565 Argininosuccinate synthase signature 2 192222003134 PS00564 Argininosuccinate synthase signature 1 192222003135 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 192222003136 HMMPfam hit to PF01479, S4 domain, score 4.5e-06 192222003137 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 192222003138 HMMPfam hit to PF02367, Uncharacterised P-loop hydrolase UPF0079, score 1e-18 192222003139 PS00017 ATP/GTP-binding site motif A (P-loop) 192222003140 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 192222003141 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 192222003142 Walker A/P-loop; other site 192222003143 ATP binding site [chemical binding]; other site 192222003144 Q-loop/lid; other site 192222003145 ABC transporter signature motif; other site 192222003146 Walker B; other site 192222003147 D-loop; other site 192222003148 H-loop/switch region; other site 192222003149 HMMPfam hit to PF00005, ABC transporter, score 8.9e-62 192222003150 PS00017 ATP/GTP-binding site motif A (P-loop) 192222003151 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 192222003152 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 192222003153 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 192222003154 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 192222003155 HMMPfam hit to PF00309, Sigma-54 factor, Activator interacting do, score 1.3e-15 192222003156 HMMPfam hit to PF04963, Sigma-54 factor, core binding domain, score 3.6e-06 192222003157 HMMPfam hit to PF04552, Sigma-54, DNA binding domain, score 3.7e-83 192222003158 PS00718 Sigma-54 factors family signature 2 192222003159 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 192222003160 12 probable transmembrane helices predicted for Cj0671 by TMHMM2.0 at aa 10-28, 33-52, 62-84, 105-127,147-169, 182-204, 247-269, 294-316, 331-353, 374-396,406-428 and 449-471 192222003161 HMMPfam hit to PF03605, Anaerobic c4-dicarboxylate membrane transpo, score 4.2e-254 192222003162 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222003163 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222003164 2 probable transmembrane helices predicted for Cj0672 by TMHMM2.0 at aa 10-32 and 39-58 192222003165 Original (2000) note: Cj0676, kdpA, probable potassium-transporting ATPase A chain pseudogene, len: 1744 bp; highly similar to e.g. ATKA_ECOLI potassium-transporting ATPase A chain (EC 3.6.1.36) (557 aa). No hp match. Note thay kdpB (Cj0677) is intact, while kdpC (Cj0678) is a pseudogene; Updated (2006) note: Pfam domain PF03814 Potassium-transporting ATPase A subunit identified within CDS. Also, ten probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. Thus, not used within product function. Coding sequence has been updated to reflect the complete amino acid sequence for the encoded protein regardless of its expression. This will cause differences from the amino acid sequence of the previous annotation. Functional classification - Transport/binding proteins -Cations; PMID:6146979, PMID:15919996 192222003166 HMMPfam hit to PF03814, Potassium-transporting ATPase A subunit, score 4e-243 192222003167 10 probable transmembrane helices predicted for Cj0676 by TMHMM2.0 at aa 4-23, 60-82, 128-150, 163-185,242-264, 281-300, 377-399, 416-438, 484-506 and 523-545 192222003168 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 192222003169 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 192222003170 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 192222003171 7 probable transmembrane helices predicted for Cj0677 by TMHMM2.0 at aa 34-56, 66-83, 218-240, 250-272,583-601, 611-633 and 646-668 192222003172 HMMPfam hit to PF00122, E1-E2 ATPase, score 4.5e-52 192222003173 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.9e-30 192222003174 PS00154 E1-E2 ATPases phosphorylation site 192222003175 PS00018 EF-hand calcium-binding domain 192222003176 Original (2000) note: Cj0678, kdpC, probable potassium-transporting ATPase C chain pseudogene, len: 553 bp; similar to e.g. ATKC_ECOLI potassium-transporting ATPase C chain (EC 3.6.1.36) (190 aa). No Hp match. Note that kdpA (Cj0676) is a pseudogene, but kdpB (Cj0677) is intact; Updated (2006) note: Pfam domain PF02669 K+-transporting ATPase, c chain identified within CDS. Also one probable transmembrane helix predicted by TMHMM2.0. Further support given to product function. Characterised within Escherichia coli with acceptable identity score. Thus, not used within product function. Coding sequence has been updated to reflect the complete amino acid sequence for the encoded protein regardless of its expression. This will cause differences from the amino acid sequence of the previous annotation. Functional classification - Transport/binding proteins -Cations; PMID:6146979, PMID:1532388 192222003177 HMMPfam hit to PF02669, K+-transporting ATPase, c chain, score 8.8e-32 192222003178 1 probable transmembrane helix predicted for Cj0678 by TMHMM2.0 at aa 5-24 192222003179 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 192222003180 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 192222003181 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 192222003182 HMMPfam hit to PF02702, Osmosensitive K+ channel His kinase sensor d, score 1.3e-150 192222003183 5 probable transmembrane helices predicted for Cj0679 by TMHMM2.0 at aa 358-377, 384-403, 413-427,432-454 and 464-486 192222003184 excinuclease ABC subunit B; Provisional; Region: PRK05298 192222003185 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 192222003186 ATP binding site [chemical binding]; other site 192222003187 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 192222003188 nucleotide binding region [chemical binding]; other site 192222003189 ATP-binding site [chemical binding]; other site 192222003190 Ultra-violet resistance protein B; Region: UvrB; pfam12344 192222003191 HMMPfam hit to PF02151, UvrB/uvrC motif, score 1.2e-11 192222003192 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 7.4e-18 192222003193 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 1.4e-06 192222003194 PS00017 ATP/GTP-binding site motif A (P-loop) 192222003195 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 0.0002 192222003196 1 probable transmembrane helix predicted for Cj0683 by TMHMM2.0 at aa 5-27 192222003197 primosome assembly protein PriA; Validated; Region: PRK05580 192222003198 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 192222003199 ATP binding site [chemical binding]; other site 192222003200 putative Mg++ binding site [ion binding]; other site 192222003201 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222003202 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 2e-06 192222003203 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 9.2e-11 192222003204 PS00017 ATP/GTP-binding site motif A (P-loop) 192222003205 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 2.2e-06 192222003206 Protein of unknown function (DUF2972); Region: DUF2972; pfam11186 192222003207 PS00225 Crystallins beta and gamma 'Greek key' motif signature 192222003208 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 192222003209 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 192222003210 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 192222003211 HMMPfam hit to PF04551, GcpE protein, score 7.5e-248 192222003212 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 192222003213 Flagellar L-ring protein; Region: FlgH; cl00905 192222003214 HMMPfam hit to PF02107, Flagellar L-ring protein,score 2.3e-49 192222003215 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222003216 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 192222003217 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 192222003218 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 192222003219 HMMPfam hit to PF01515, Phosphate acetyl/butaryl transferase, score 2e-159 192222003220 Acetokinase family; Region: Acetate_kinase; cl01029 192222003221 propionate/acetate kinase; Provisional; Region: PRK12379 192222003222 HMMPfam hit to PF00871, Acetokinase family, score 1.4e-188 192222003223 PS01075 Acetate and butyrate kinases family signature 1 192222003224 PS01076 Acetate and butyrate kinases family signature 2 192222003225 Uncharacterized conserved protein [Function unknown]; Region: COG4748 192222003226 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 192222003227 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 192222003228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222003229 PS00092 N-6 Adenine-specific DNA methylases signature 192222003230 HMMPfam hit to PF04313, Type I restriction enzyme R protein N termin, score 3.1e-21 192222003231 2 probable transmembrane helices predicted for Cj0691 by TMHMM2.0 at aa 53-75 and 80-102 192222003232 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222003233 1 probable transmembrane helix predicted for Cj0692c by TMHMM2.0 at aa 243-265 192222003234 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 192222003235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222003236 HMMPfam hit to PF01795, MraW methylase family,score 7.1e-110 192222003237 SurA N-terminal domain; Region: SurA_N_3; cl07813 192222003238 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 192222003239 PPIC-type PPIASE domain; Region: Rotamase; cl08278 192222003240 1 probable transmembrane helix predicted for Cj0694 by TMHMM2.0 at aa 12-34 192222003241 cell division protein FtsA; Region: ftsA; TIGR01174 192222003242 Cell division protein FtsA; Region: FtsA; cl11496 192222003243 Cell division protein FtsA; Region: FtsA; cl11496 192222003244 HMMPfam hit to PF02491, Cell division protein FtsA,score 4.3e-31 192222003245 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222003246 HMMPfam hit to PF02491, Cell division protein FtsA,score 2.1e-21 192222003247 cell division protein FtsZ; Validated; Region: PRK09330 192222003248 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 192222003249 nucleotide binding site [chemical binding]; other site 192222003250 SulA interaction site; other site 192222003251 HMMPfam hit to PF00091, Tubulin/FtsZ family, GTPase domain, score 1.9e-81 192222003252 PS01135 FtsZ protein signature 2 192222003253 HMMPfam hit to PF03953, Tubulin/FtsZ family,C-terminal domain, score 4e-25 192222003254 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 192222003255 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 192222003256 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 192222003257 HMMPfam hit to PF00460, Flagella basal body rod protein, score 9.9e-09 192222003258 PS00588 Flagella basal body rod proteins signature 192222003259 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 0.0011 192222003260 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 192222003261 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 192222003262 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 192222003263 HMMPfam hit to PF00460, Flagella basal body rod protein, score 5.6e-13 192222003264 PS00588 Flagella basal body rod proteins signature 192222003265 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 1.2e-19 192222003266 glutamine synthetase, type I; Region: GlnA; TIGR00653 192222003267 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 192222003268 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 192222003269 HMMPfam hit to PF00120, Glutamine synthetase,catalytic domain, score 8.5e-160 192222003270 PS00181 Glutamine synthetase ATP-binding region signature 192222003271 HMMPfam hit to PF03951, Glutamine synthetase,beta-Grasp domain, score 6e-42 192222003272 PS00180 Glutamine synthetase signature 1 192222003273 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 192222003274 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 192222003275 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 192222003276 Peptidase family U32; Region: Peptidase_U32; cl03113 192222003277 HMMPfam hit to PF01136, Peptidase family U32, score 8.5e-117 192222003278 PS01276 Peptidase family U32 signature 192222003279 AIR carboxylase; Region: AIRC; cl00310 192222003280 HMMPfam hit to PF00731, AIR carboxylase, score 1.1e-72 192222003281 Protein of unknown function (DUF3972); Region: DUF3972; pfam13118 192222003282 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 192222003283 dimer interface [polypeptide binding]; other site 192222003284 motif 1; other site 192222003285 active site 192222003286 motif 2; other site 192222003287 motif 3; other site 192222003288 HMMPfam hit to PF02091, Glycyl-tRNA synthetase alpha subunit, score 4.8e-203 192222003289 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 192222003290 Uncharacterized conserved protein [Function unknown]; Region: COG0327 192222003291 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 192222003292 HMMPfam hit to PF01784, NIF3 (NGG1p interacting factor 3), score 3.6e-81 192222003293 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 192222003294 Putative zinc ribbon domain; Region: DUF164; pfam02591 192222003295 HMMPfam hit to PF02591, Uncharacterized ACR,COG1579, score 8.4e-50 192222003296 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 192222003297 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 192222003298 2 probable transmembrane helices predicted for Cj0707 by TMHMM2.0 at aa 4-26 and 111-130 192222003299 HMMPfam hit to PF04413,3-Deoxy-D-manno-octulosonic-acid tran, score 7.3e-80 192222003300 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 192222003301 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 192222003302 active site 192222003303 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 1.7e-20 192222003304 PS01129 Rlu family of pseudouridine synthase signature 192222003305 signal recognition particle protein; Provisional; Region: PRK10867 192222003306 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 192222003307 P loop; other site 192222003308 GTP binding site [chemical binding]; other site 192222003309 Signal peptide binding domain; Region: SRP_SPB; pfam02978 192222003310 HMMPfam hit to PF02881, SRP54-type protein, helical bundle domain, score 2.4e-08 192222003311 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 9.5e-103 192222003312 PS00017 ATP/GTP-binding site motif A (P-loop) 192222003313 PS00300 SRP54-type proteins GTP-binding domain signature 192222003314 HMMPfam hit to PF02978, Signal peptide binding domain, score 4.4e-45 192222003315 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 192222003316 PS00732 Ribosomal protein S16 signature 192222003317 HMMPfam hit to PF00886, Ribosomal protein S16,score 5.6e-33 192222003318 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 192222003319 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 192222003320 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 192222003321 RimM N-terminal domain; Region: RimM; pfam01782 192222003322 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 192222003323 HMMPfam hit to PF01782, RimM N-terminal domain,score 2.2e-20 192222003324 HMMPfam hit to PF05239, PRC-barrel domain, score 1.2e-15 192222003325 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 192222003326 HMMPfam hit to PF01746, tRNA (Guanine-1)-methyltransferase, score 1.3e-82 192222003327 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 192222003328 HMMPfam hit to PF01245, Ribosomal protein L19,score 5.1e-63 192222003329 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 192222003330 active site 192222003331 homotetramer interface [polypeptide binding]; other site 192222003332 HMMPfam hit to PF00576, Transthyretin precursor (formerly preal, score 7.3e-62 192222003333 PS00768 Transthyretin signature 1 192222003334 PS00769 Transthyretin signature 2 192222003335 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 192222003336 HMMPfam hit to PF01474, Class-II DAHP synthetase family, score 8.4e-246 192222003337 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222003338 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 192222003339 ArsC family; Region: ArsC; pfam03960 192222003340 HMMPfam hit to PF03960, ArsC family, score 6.9e-34 192222003341 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 192222003342 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 192222003343 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 192222003344 generic binding surface I; other site 192222003345 generic binding surface II; other site 192222003346 HMMPfam hit to PF02231, PHP domain N-terminal region, score 4.7e-29 192222003347 HMMPfam hit to PF02811, PHP domain C-terminal region, score 1.6e-34 192222003348 HMMPfam hit to PF07733, Bacterial DNA polymerase III alpha sub, score 2.2e-295 192222003349 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 192222003350 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 192222003351 catalytic residue [active] 192222003352 HMMPfam hit to PF01168, Alanine racemase,N-terminal domain, score 2e-05 192222003353 PS01211 Uncharacterized protein family UPF0001 signature 192222003354 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 192222003355 flagellin; Provisional; Region: PRK12804 192222003356 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 6.9e-05 192222003357 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 192222003358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 192222003359 S-adenosylmethionine binding site [chemical binding]; other site 192222003360 PS00092 N-6 Adenine-specific DNA methylases signature 192222003361 Peptidase family M48; Region: Peptidase_M48; cl12018 192222003362 HMMPfam hit to PF01435, Peptidase family M48, score 1.9e-43 192222003363 PS00142 Neutral zinc metallopeptidases,zinc-binding region signature 192222003364 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 192222003365 MPT binding site; other site 192222003366 trimer interface [polypeptide binding]; other site 192222003367 HMMPfam hit to PF00994, Probable molybdopterin binding domain, score 6.3e-45 192222003368 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 192222003369 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 192222003370 HMMPfam hit to PF01544, CorA-like Mg2+ transporter protein, score 1.6e-61 192222003371 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 192222003372 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 192222003373 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 0.0028 192222003374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 192222003375 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 192222003376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 192222003377 6 probable transmembrane helices predicted for Cj0730 by TMHMM2.0 at aa 7-29, 66-88, 108-130, 145-167,187-209 and 248-270 192222003378 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 0.0008 192222003379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 192222003380 dimer interface [polypeptide binding]; other site 192222003381 conserved gate region; other site 192222003382 putative PBP binding loops; other site 192222003383 ABC-ATPase subunit interface; other site 192222003384 7 probable transmembrane helices predicted for Cj0731 by TMHMM2.0 at aa 12-34, 75-97, 104-126, 131-153,165-187, 192-214 and 235-257 192222003385 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 0.0085 192222003386 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 192222003387 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 192222003388 Walker A/P-loop; other site 192222003389 ATP binding site [chemical binding]; other site 192222003390 Q-loop/lid; other site 192222003391 ABC transporter signature motif; other site 192222003392 Walker B; other site 192222003393 D-loop; other site 192222003394 H-loop/switch region; other site 192222003395 TOBE domain; Region: TOBE_2; cl01440 192222003396 HMMPfam hit to PF00005, ABC transporter, score 4.1e-70 192222003397 PS00017 ATP/GTP-binding site motif A (P-loop) 192222003398 PS00211 ABC transporters family signature 192222003399 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 192222003400 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 192222003401 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 0.0017 192222003402 PS00215 Mitochondrial energy transfer proteins signature 192222003403 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 192222003404 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 192222003405 substrate binding pocket [chemical binding]; other site 192222003406 membrane-bound complex binding site; other site 192222003407 hinge residues; other site 192222003408 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 4.4e-67 192222003409 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature 192222003410 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222003411 1 probable transmembrane helix predicted for Cj0735 by TMHMM2.0 at aa 19-41 192222003412 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 192222003413 haemagglutination activity domain; Region: Haemagg_act; cl05436 192222003414 1 probable transmembrane helix predicted for Cj0737 by TMHMM2.0 at aa 7-29 192222003415 HMMPfam hit to PF05860, haemagglutination activity domain, score 3.3e-11 192222003416 Original (2000) note: Cj0742, probable outer membrane protein pseudogene, len: 1567 bp; similar to parts of Cj0975 (H. inf. hxuB-like). No Hp match; Updated (2006) note: No specific characterisation with acceptable identity scores. Thus, kept within product function. Coding sequence has been updated to reflect the complete amino acid sequence for the encoded protein regardless of its expression. This will cause differences from the amino acid sequence of the previous annotation. Functional classification -Membranes, lipoproteins and porins 192222003417 Original (2000) note: Cj0752, probable IS element transposase pseudogene, len: 1113 bp; similar to parts of e.g. TR:O06526 (EMBL:U95957) H. pylori transposase homolog B (442 aa). Similar to several Hp genes e.g. HP1095,HP0997, HP0989, HP0438, HP1534. No other C.j. matches; Updated (2006) note: Pfam domains PF01385 Probable transposase and PF07282 transposase DNA-binding domain were both identified within CDS. Further support given to product function. Similarity and characterisation work within Helicobacter pylori has led to not being added to product function. Coding sequence has been updated to reflect the complete amino acid sequence for the encoded protein regardless of its expression. This will cause differences from the amino acid sequence of the previous annotation. Functional classification - IS elements; PMID:9858724, PMID:15019987 192222003418 HMMPfam hit to PF01385, Probable transposase, score 7e-08 192222003419 HMMPfam hit to PF07282, transposase DNA-binding domai, score 1.1e-33 192222003420 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 192222003421 Gram-negative bacterial tonB protein; Region: TonB; cl10048 192222003422 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 4.1e-13 192222003423 1 probable transmembrane helix predicted for Cj0753c by TMHMM2.0 at aa 12-29 192222003424 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 192222003425 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 192222003426 N-terminal plug; other site 192222003427 ligand-binding site [chemical binding]; other site 192222003428 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 4.3e-21 192222003429 HMMPfam hit to PF00593, TonB dependent receptor,score 2.4e-27 192222003430 heat-inducible transcription repressor; Provisional; Region: PRK03911 192222003431 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 192222003432 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 192222003433 dimer interface [polypeptide binding]; other site 192222003434 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 192222003435 HMMPfam hit to PF01025, GrpE, score 4.9e-55 192222003436 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 192222003437 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 192222003438 HMMPfam hit to PF00012, Hsp70 protein, score 0 192222003439 PS00297 Heat shock hsp70 proteins family signature 1 192222003440 PS00329 Heat shock hsp70 proteins family signature 2 192222003441 PS01036 Heat shock hsp70 proteins family signature 3 192222003442 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 192222003443 Cupin domain; Region: Cupin_2; cl09118 192222003444 aspartate aminotransferase; Provisional; Region: PRK05764 192222003445 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 192222003446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222003447 homodimer interface [polypeptide binding]; other site 192222003448 catalytic residue [active] 192222003449 HMMPfam hit to PF00155, Aminotransferase class I and II, score 5.3e-50 192222003450 serine O-acetyltransferase; Region: cysE; TIGR01172 192222003451 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 192222003452 trimer interface [polypeptide binding]; other site 192222003453 active site 192222003454 substrate binding site [chemical binding]; other site 192222003455 CoA binding site [chemical binding]; other site 192222003456 PS00101 Hexapeptide-repeat containing-transferases signature 192222003457 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.31 192222003458 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 17 192222003459 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.077 192222003460 arginine decarboxylase; Provisional; Region: PRK05354 192222003461 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 192222003462 dimer interface [polypeptide binding]; other site 192222003463 active site 192222003464 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 192222003465 catalytic residues [active] 192222003466 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 192222003467 HMMPfam hit to PF00278, Pyridoxal-dependent decarboxylase, C-, score 2.2e-08 192222003468 HMMPfam hit to PF02784, Pyridoxal-dependent decarboxylase, py, score 1.7e-39 192222003469 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site 192222003470 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 192222003471 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 192222003472 dimer interface [polypeptide binding]; other site 192222003473 motif 1; other site 192222003474 active site 192222003475 motif 2; other site 192222003476 motif 3; other site 192222003477 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 192222003478 anticodon binding site; other site 192222003479 HMMPfam hit to PF03129, Anticodon binding domain,score 0.018 192222003480 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 192222003481 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 1.5e-36 192222003482 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 192222003483 thymidylate kinase; Validated; Region: tmk; PRK00698 192222003484 TMP-binding site; other site 192222003485 ATP-binding site [chemical binding]; other site 192222003486 HMMPfam hit to PF02223, Thymidylate kinase, score 5.9e-33 192222003487 PS01331 Thymidylate kinase signature 192222003488 PS00017 ATP/GTP-binding site motif A (P-loop) 192222003489 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 192222003490 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 192222003491 active site 192222003492 (T/H)XGH motif; other site 192222003493 HMMPfam hit to PF01467, Cytidylyltransferase, score 1.9e-29 192222003494 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 192222003495 Flavoprotein; Region: Flavoprotein; cl08021 192222003496 HMMPfam hit to PF02441, Flavoprotein, score 2.5e-29 192222003497 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK08515 192222003498 SAF domain; Region: SAF; cl00555 192222003499 HMMPfam hit to PF03240, FlgA family, score 8e-05 192222003500 NMT1-like family; Region: NMT1_2; cl15260 192222003501 HMMPfam hit to PF03180, NLPA lipoprotein, score 5.2e-129 192222003502 1 probable transmembrane helix predicted for Cj0770c by TMHMM2.0 at aa 7-29 192222003503 NMT1-like family; Region: NMT1_2; cl15260 192222003504 HMMPfam hit to PF03180, NLPA lipoprotein, score 2.2e-132 192222003505 NMT1-like family; Region: NMT1_2; cl15260 192222003506 HMMPfam hit to PF03180, NLPA lipoprotein, score 1.1e-145 192222003507 PS00430 TonB-dependent receptor proteins signature 1 192222003508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 192222003509 ABC-ATPase subunit interface; other site 192222003510 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.9e-15 192222003511 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 192222003512 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 192222003513 Walker A/P-loop; other site 192222003514 ATP binding site [chemical binding]; other site 192222003515 Q-loop/lid; other site 192222003516 ABC transporter signature motif; other site 192222003517 Walker B; other site 192222003518 D-loop; other site 192222003519 H-loop/switch region; other site 192222003520 NIL domain; Region: NIL; cl09633 192222003521 HMMPfam hit to PF00005, ABC transporter, score 1.8e-69 192222003522 PS00211 ABC transporters family signature 192222003523 PS00017 ATP/GTP-binding site motif A (P-loop) 192222003524 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 192222003525 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 192222003526 active site 192222003527 HIGH motif; other site 192222003528 nucleotide binding site [chemical binding]; other site 192222003529 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 192222003530 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 192222003531 active site 192222003532 KMSKS motif; other site 192222003533 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 192222003534 tRNA binding surface [nucleotide binding]; other site 192222003535 anticodon binding site; other site 192222003536 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 192222003537 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 1.7e-207 192222003538 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 192222003539 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 192222003540 1 probable transmembrane helix predicted for Cj0776c by TMHMM2.0 at aa 5-27 192222003541 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 192222003542 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222003543 Family description; Region: UvrD_C_2; cl15862 192222003544 HMMPfam hit to PF00580, UvrD/REP helicase, score 1.6e-90 192222003545 PS00017 ATP/GTP-binding site motif A (P-loop) 192222003546 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 192222003547 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 192222003548 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 192222003549 dimer interface [polypeptide binding]; other site 192222003550 catalytic triad [active] 192222003551 peroxidatic and resolving cysteines [active] 192222003552 HMMPfam hit to PF00578, AhpC/TSA family, score 3.8e-21 192222003553 PS01265 Tpx family signature 192222003554 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222003555 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 192222003556 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 192222003557 molybdopterin cofactor binding site; other site 192222003558 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 192222003559 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 192222003560 molybdopterin cofactor binding site; other site 192222003561 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 do, score 2.3e-23 192222003562 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1 192222003563 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 6.2e-85 192222003564 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 3e-32 192222003565 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 192222003566 4Fe-4S binding domain; Region: Fer4; cl02805 192222003567 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 192222003568 1 probable transmembrane helix predicted for Cj0781 by TMHMM2.0 at aa 7-29 192222003569 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 6.2e-06 192222003570 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222003571 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.0011 192222003572 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 192222003573 4Fe-4S binding domain; Region: Fer4_5; pfam12801 192222003574 4Fe-4S binding domain; Region: Fer4; cl02805 192222003575 6 probable transmembrane helices predicted for Cj0782 by TMHMM2.0 at aa 13-32, 52-74, 81-99, 119-141,148-170 and 174-195 192222003576 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.00013 192222003577 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222003578 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.0015 192222003579 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 192222003580 HMMPfam hit to PF03892, Nitrate reductase cytochrome c-type subunit, score 2.5e-103 192222003581 1 probable transmembrane helix predicted for Cj0783 by TMHMM2.0 at aa 7-26 192222003582 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222003583 PS00190 Cytochrome c family heme-binding site signature 192222003584 PS00190 Cytochrome c family heme-binding site signature 192222003585 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 192222003586 NapD protein; Region: NapD; cl01163 192222003587 HMMPfam hit to PF03927, NapD protein, score 4.9e-34 192222003588 1 probable transmembrane helix predicted for Cj0786 by TMHMM2.0 at aa 4-22 192222003589 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 192222003590 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 192222003591 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 192222003592 active site 192222003593 NTP binding site [chemical binding]; other site 192222003594 metal binding triad [ion binding]; metal-binding site 192222003595 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 192222003596 PS00017 ATP/GTP-binding site motif A (P-loop) 192222003597 HMMPfam hit to PF01743, Poly A polymerase family,score 5.6e-32 192222003598 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 192222003599 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 192222003600 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 192222003601 putative active site [active] 192222003602 putative substrate binding site [chemical binding]; other site 192222003603 putative cosubstrate binding site; other site 192222003604 catalytic site [active] 192222003605 HMMPfam hit to PF00551, Formyl transferase, score 4e-55 192222003606 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 192222003607 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 192222003608 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 192222003609 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 192222003610 catalytic residue [active] 192222003611 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site 192222003612 PS00455 AMP-binding domain signature 192222003613 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 192222003614 HMMPfam hit to PF03008, Archaea bacterial proteins of unknown functi, score 1.6e-05 192222003615 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 192222003616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 192222003617 dimer interface [polypeptide binding]; other site 192222003618 phosphorylation site [posttranslational modification] 192222003619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 192222003620 ATP binding site [chemical binding]; other site 192222003621 Mg2+ binding site [ion binding]; other site 192222003622 G-X-G motif; other site 192222003623 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 5.3e-09 192222003624 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.1e-21 192222003625 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 192222003626 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 192222003627 HMMPfam hit to PF02875, Mur ligase family,glutamate ligase doma, score 0.0036 192222003628 HMMPfam hit to PF01225, Mur ligase family,catalytic domain, score 3.5e-15 192222003629 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 192222003630 HMMPfam hit to PF00561, alpha/beta hydrolase fold,score 0.0025 192222003631 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 192222003632 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 192222003633 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 192222003634 ATP-grasp domain; Region: ATP-grasp_4; cl03087 192222003635 HMMPfam hit to PF07478, D-ala D-ala ligase C-terminus, score 3.3e-23 192222003636 PS00844 D-alanine--D-alanine ligase signature 2 192222003637 PS00843 D-alanine--D-alanine ligase signature 1 192222003638 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14601 192222003639 RuvA N terminal domain; Region: RuvA_N; pfam01330 192222003640 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 192222003641 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 192222003642 HMMPfam hit to PF07499, RuvA, C-terminal domain,score 7.9e-06 192222003643 HMMPfam hit to PF00633, Helix-hairpin-helix motif,score 0.13 192222003644 HMMPfam hit to PF00633, Helix-hairpin-helix motif,score 0.66 192222003645 HMMPfam hit to PF01330, RuvA N terminal domain,score 1.7e-20 192222003646 1 probable transmembrane helix predicted for Cj0799c by TMHMM2.0 at aa 15-37 192222003647 Protein of unknown function (DUF342); Region: DUF342; pfam03961 192222003648 PS00389 ATP synthase delta (OSCP) subunit signature 192222003649 integral membrane protein MviN; Region: mviN; TIGR01695 192222003650 11 probable transmembrane helices predicted for Cj0801 by TMHMM2.0 at aa 5-24, 28-47, 79-101, 123-145,152-171, 181-203, 310-332, 347-369, 382-404, 408-430 and 442-464 192222003651 HMMPfam hit to PF03023, MviN-like protein, score 1.6e-84 192222003652 PS00225 Crystallins beta and gamma 'Greek key' motif signature 192222003653 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 192222003654 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 192222003655 active site 192222003656 HIGH motif; other site 192222003657 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 192222003658 KMSKS motif; other site 192222003659 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 192222003660 tRNA binding surface [nucleotide binding]; other site 192222003661 anticodon binding site; other site 192222003662 HMMPfam hit to PF01406, tRNA synthetases class I (C) catalytic d, score 5.6e-134 192222003663 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 192222003664 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 192222003665 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222003666 Walker A/P-loop; other site 192222003667 ATP binding site [chemical binding]; other site 192222003668 Q-loop/lid; other site 192222003669 ABC transporter signature motif; other site 192222003670 Walker B; other site 192222003671 D-loop; other site 192222003672 H-loop/switch region; other site 192222003673 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 8.8e-42 192222003674 4 probable transmembrane helices predicted for Cj0803 by TMHMM2.0 at aa 25-47, 60-82, 165-184 and 272-294 192222003675 HMMPfam hit to PF00005, ABC transporter, score 4.9e-51 192222003676 PS00017 ATP/GTP-binding site motif A (P-loop) 192222003677 PS00211 ABC transporters family signature 192222003678 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 192222003679 quinone interaction residues [chemical binding]; other site 192222003680 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 192222003681 active site 192222003682 catalytic residues [active] 192222003683 FMN binding site [chemical binding]; other site 192222003684 substrate binding site [chemical binding]; other site 192222003685 HMMPfam hit to PF01180, Dihydroorotate dehydrogenase, score 6.1e-84 192222003686 PS00911 Dihydroorotate dehydrogenase signature 1 192222003687 PS00912 Dihydroorotate dehydrogenase signature 2 192222003688 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 192222003689 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 192222003690 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 192222003691 HMMPfam hit to PF00675, Insulinase (Peptidase family M16), score 1.2e-15 192222003692 PS00143 Insulinase family, zinc-binding region signature 192222003693 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 4.8e-42 192222003694 dihydrodipicolinate synthase; Region: dapA; TIGR00674 192222003695 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 192222003696 dimer interface [polypeptide binding]; other site 192222003697 active site 192222003698 catalytic residue [active] 192222003699 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase family, score 2e-106 192222003700 PS00665 Dihydrodipicolinate synthetase signature 1 192222003701 PS00666 Dihydrodipicolinate synthetase signature 2 192222003702 7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416 192222003703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222003704 NAD(P) binding site [chemical binding]; other site 192222003705 active site 192222003706 HMMPfam hit to PF00106, short chain dehydrogenase,score 1e-43 192222003707 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 192222003708 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 3.6e-34 192222003709 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 192222003710 NAD synthase; Region: NAD_synthase; pfam02540 192222003711 homodimer interface [polypeptide binding]; other site 192222003712 NAD binding pocket [chemical binding]; other site 192222003713 ATP binding pocket [chemical binding]; other site 192222003714 Mg binding site [ion binding]; other site 192222003715 active-site loop [active] 192222003716 HMMPfam hit to PF02540, NAD synthase, score 7.9e-62 192222003717 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 192222003718 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 192222003719 HMMPfam hit to PF02606, Tetraacyldisaccharide-1-P 4'-kinase, score 1e-24 192222003720 1 probable transmembrane helix predicted for Cj0811 by TMHMM2.0 at aa 24-46 192222003721 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 192222003722 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 192222003723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222003724 catalytic residue [active] 192222003725 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 4e-08 192222003726 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site 192222003727 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 192222003728 Ligand binding site; other site 192222003729 oligomer interface; other site 192222003730 HMMPfam hit to PF02348, Cytidylyltransferase, score 1.9e-54 192222003731 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 192222003732 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 192222003733 substrate binding pocket [chemical binding]; other site 192222003734 membrane-bound complex binding site; other site 192222003735 hinge residues; other site 192222003736 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 1.3e-79 192222003737 1 probable transmembrane helix predicted for Cj0818 by TMHMM2.0 at aa 4-21 192222003738 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222003739 2 probable transmembrane helices predicted for Cj0819 by TMHMM2.0 at aa 23-42 and 47-69 192222003740 FliP family; Region: FliP; cl00593 192222003741 HMMPfam hit to PF00813, FliP family, score 1.4e-113 192222003742 PS01061 Flagella transport protein fliP family signature 2 192222003743 PS01060 Flagella transport protein fliP family signature 1 192222003744 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14359 192222003745 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 192222003746 Substrate binding site; other site 192222003747 Mg++ binding site; other site 192222003748 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 192222003749 active site 192222003750 substrate binding site [chemical binding]; other site 192222003751 CoA binding site [chemical binding]; other site 192222003752 HMMPfam hit to PF00483, Nucleotidyl transferase,score 1.9e-06 192222003753 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 15 192222003754 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 45 192222003755 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 15 192222003756 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 58 192222003757 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 192222003758 Flavoprotein; Region: Flavoprotein; cl08021 192222003759 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 192222003760 HMMPfam hit to PF02441, Flavoprotein, score 1.3e-25 192222003761 HMMPfam hit to PF04127, DNA / pantothenate metabolism flavoprote, score 1.2e-16 192222003762 1 probable transmembrane helix predicted for Cj0823 by TMHMM2.0 at aa 145-167 192222003763 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 192222003764 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 192222003765 catalytic residue [active] 192222003766 putative FPP diphosphate binding site; other site 192222003767 putative FPP binding hydrophobic cleft; other site 192222003768 dimer interface [polypeptide binding]; other site 192222003769 putative IPP diphosphate binding site; other site 192222003770 HMMPfam hit to PF01255, UDP diphosphate syntha, score 2.6e-72 192222003771 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 192222003772 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 192222003773 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222003774 7 probable transmembrane helices predicted for Cj0825 by TMHMM2.0 at aa 5-24, 67-89, 93-112, 119-136,151-173, 203-225 and 235-257 192222003775 HMMPfam hit to PF06750, Bacterial Peptidase A24 N-terminal doma, score 1.1e-39 192222003776 HMMPfam hit to PF01478, Type IV leader peptidase family, score 2.3e-17 192222003777 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 192222003778 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 192222003779 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ family, score 1.5e-77 192222003780 6 probable transmembrane helices predicted for Cj0826 by TMHMM2.0 at aa 13-35, 55-77, 106-128, 261-283,290-307 and 311-333 192222003781 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 192222003782 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 192222003783 dimerization interface 3.5A [polypeptide binding]; other site 192222003784 active site 192222003785 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 1.1e-21 192222003786 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 2.4e-12 192222003787 threonine dehydratase; Provisional; Region: PRK08526 192222003788 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 192222003789 tetramer interface [polypeptide binding]; other site 192222003790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222003791 catalytic residue [active] 192222003792 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 192222003793 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 1e-81 192222003794 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site 192222003795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222003796 HMMPfam hit to PF02629, CoA binding domain, score 0.00014 192222003797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 192222003798 4 probable transmembrane helices predicted for Cj0830 by TMHMM2.0 at aa 10-32, 45-67, 77-99 and 112-134 192222003799 HMMPfam hit to PF04323, Protein of unknown function (DUF474), score 2.5e-45 192222003800 tRNA (uracil-5-)-methyltransferase; Region: trmA_only; TIGR02143 192222003801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 192222003802 HMMPfam hit to PF05958, tRNA (Uracil-5-)-methyltransferase, score 2.6e-240 192222003803 PS01230 RNA methyltransferase trmA family signature 1 192222003804 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 192222003805 HMMPfam hit to PF03553, Na+/H+ antiporter family,score 5.2e-102 192222003806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222003807 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 192222003808 NAD(P) binding site [chemical binding]; other site 192222003809 active site 192222003810 HMMPfam hit to PF00106, short chain dehydrogenase,score 7.9e-49 192222003811 PS00061 Short-chain dehydrogenases/reductases family signature 192222003812 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 192222003813 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 192222003814 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 192222003815 HMMPfam hit to PF00023, Ankyrin repeat, score 1.8e-06 192222003816 HMMPfam hit to PF00023, Ankyrin repeat, score 1.9e-07 192222003817 HMMPfam hit to PF00023, Ankyrin repeat, score 7.2 192222003818 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 192222003819 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 192222003820 substrate binding site [chemical binding]; other site 192222003821 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 192222003822 substrate binding site [chemical binding]; other site 192222003823 ligand binding site [chemical binding]; other site 192222003824 HMMPfam hit to PF00330, Aconitase family (aconitate hydratase), score 2.3e-09 192222003825 PS01244 Aconitase family signature 2 192222003826 PS00450 Aconitase family signature 1 192222003827 HMMPfam hit to PF06434, Aconitate hydratase, score 3.2e-259 192222003828 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 192222003829 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 192222003830 DNA binding site [nucleotide binding] 192222003831 active site 192222003832 HMMPfam hit to PF01035, 6-O-methylguanine DNA methyltransferas, score 1.1e-41 192222003833 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site 192222003834 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 192222003835 PS00030 Eukaryotic RNA-binding region RNP-1 signature 192222003836 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 192222003837 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 192222003838 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 192222003839 active site 192222003840 HIGH motif; other site 192222003841 KMSKS motif; other site 192222003842 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 192222003843 tRNA binding surface [nucleotide binding]; other site 192222003844 anticodon binding site; other site 192222003845 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 192222003846 putative tRNA-binding site [nucleotide binding]; other site 192222003847 dimer interface [polypeptide binding]; other site 192222003848 HMMPfam hit to PF01588, tRNA binding domain, score 3.8e-30 192222003849 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 8.9e-08 192222003850 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 192222003851 AMP binding site [chemical binding]; other site 192222003852 metal binding site [ion binding]; metal-binding site 192222003853 active site 192222003854 HMMPfam hit to PF00316,Fructose-1-6-bisphosphatase, score 1.1e-52 192222003855 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 192222003856 Walker A motif; other site 192222003857 HMMPfam hit to PF03205, Molybdopterin guanine dinucleotide synthesis, score 1.2e-21 192222003858 PS00017 ATP/GTP-binding site motif A (P-loop) 192222003859 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222003860 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 192222003861 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 192222003862 N-acetyl-D-glucosamine binding site [chemical binding]; other site 192222003863 catalytic residue [active] 192222003864 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 1.1e-20 192222003865 PS00922 Prokaryotic transglycosylases signature 192222003866 YGGT family; Region: YGGT; cl00508 192222003867 HMMPfam hit to PF02325, YGGT family, score 6.1e-20 192222003868 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 192222003869 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 192222003870 active site 192222003871 HIGH motif; other site 192222003872 nucleotide binding site [chemical binding]; other site 192222003873 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 192222003874 active site 192222003875 KMSKS motif; other site 192222003876 HMMPfam hit to PF00749, tRNA synthetases class I (E and Q), cata, score 1.1e-85 192222003877 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 192222003878 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 192222003879 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 192222003880 putative active site [active] 192222003881 putative metal binding site [ion binding]; other site 192222003882 4 probable transmembrane helices predicted for Cj0846 by TMHMM2.0 at aa 4-22, 34-56, 71-93 and 106-128 192222003883 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 1.2e-12 192222003884 PS00142 Neutral zinc metallopeptidases,zinc-binding region signature 192222003885 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 192222003886 HMMPfam hit to PF02666, Phosphatidylserine decarboxylase, score 1.8e-45 192222003887 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 192222003888 Ring-infected erythrocyte surface antigen; Provisional; Region: PTZ00341 192222003889 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 192222003890 PS00063 Aldo/keto reductase family active site signature 192222003891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 192222003892 putative substrate translocation pore; other site 192222003893 Major Facilitator Superfamily; Region: MFS_1; pfam07690 192222003894 HMMPfam hit to PF00083, Sugar (and other) transporter, score 4.6e-05 192222003895 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.5e-24 192222003896 PS00216 Sugar transport proteins signature 1 192222003897 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222003898 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 192222003899 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 192222003900 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 192222003901 inhibitor-cofactor binding pocket; inhibition site 192222003902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222003903 catalytic residue [active] 192222003904 HMMPfam hit to PF00202, Aminotransferase class-III,score 3.5e-96 192222003905 ubiquitin-activating enzyme E1; Region: Ube1; TIGR01408 192222003906 PS00190 Cytochrome c family heme-binding site signature 192222003907 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14166 192222003908 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 192222003909 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 192222003910 homodimer interface [polypeptide binding]; other site 192222003911 NADP binding site [chemical binding]; other site 192222003912 substrate binding site [chemical binding]; other site 192222003913 HMMPfam hit to PF00763, Tetrahydrofolate dehydrogenase/cyclohyd, score 3.6e-53 192222003914 PS00766 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1 192222003915 HMMPfam hit to PF02882, Tetrahydrofolate dehydrogenase/cyclohyd, score 8.6e-103 192222003916 PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2 192222003917 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 192222003918 Catalytic site [active] 192222003919 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 192222003920 1 probable transmembrane helix predicted for Cj0856 by TMHMM2.0 at aa 13-35 192222003921 HMMPfam hit to PF00717, Peptidase S24-like, score 6e-18 192222003922 PS00761 Signal peptidases I signature 3 192222003923 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 192222003924 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 192222003925 dimer interface [polypeptide binding]; other site 192222003926 putative functional site; other site 192222003927 putative MPT binding site; other site 192222003928 HMMPfam hit to PF03454, MoeA C-terminal region (domain IV), score 0.01 192222003929 HMMPfam hit to PF00994, Probable molybdopterin binding domain, score 4.8e-24 192222003930 HMMPfam hit to PF03453, MoeA N-terminal region (domain I and II, score 6.8e-67 192222003931 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 192222003932 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 192222003933 hinge; other site 192222003934 active site 192222003935 HMMPfam hit to PF00275, EPSP synthase (3-phosphoshikimate 1-car, score 6.4e-129 192222003936 PS00017 ATP/GTP-binding site motif A (P-loop) 192222003937 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 192222003938 EamA-like transporter family; Region: EamA; cl01037 192222003939 10 probable transmembrane helices predicted for Cj0860 by TMHMM2.0 at aa 2-24, 28-50, 63-82, 92-111,118-136, 146-168, 175-197, 212-231, 238-260 and 265-284 192222003940 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 4.2e-14 192222003941 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 5.2e-17 192222003942 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 192222003943 Glutamine amidotransferase class-I; Region: GATase; pfam00117 192222003944 glutamine binding [chemical binding]; other site 192222003945 catalytic triad [active] 192222003946 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 1.2e-59 192222003947 chorismate binding enzyme; Region: Chorismate_bind; cl10555 192222003948 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 192222003949 substrate-cofactor binding pocket; other site 192222003950 homodimer interface [polypeptide binding]; other site 192222003951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222003952 catalytic residue [active] 192222003953 HMMPfam hit to PF00425, chorismate binding enzyme,score 7.6e-45 192222003954 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 192222003955 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 192222003956 active site 192222003957 DNA binding site [nucleotide binding] 192222003958 Int/Topo IB signature motif; other site 192222003959 HMMPfam hit to PF00589, Phage integrase family,score 9.8e-27 192222003960 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 192222003961 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 192222003962 4 probable transmembrane helices predicted for Cj0865 by TMHMM2.0 at aa 25-47, 62-81, 198-220 and 230-247 192222003963 Original (2000) note: Cj0866, ast, arylsulfatase pseudogene, len: 1434 bp; almost identical to parts of TR:Q46098 (EMBL:U38280 Campylobacter jejuni strain 81-176 arylsulfatase (620 aa), and similar to parts of TR:P97036 (EMBL:U32616) Klebsiella pneumoniae arylsulfate sulfotransferase (EC 2.8.2.22) (598 aa). No Hp match; Updated (2006) note: Pfam domain PF05935 Arylsulfotransferase (ASST) identified within CDS. Part of stem loop also identified within C-terminal. Further support given to product function. Characterisation paper with Campylobacter jejuni included. Thus, not added to product function. Coding sequence has been updated to reflect the complete amino acid sequence for the encoded protein regardless of its expression. This will cause differences from the amino acid sequence of the previous annotation. Functional classification - Central intermediary metabolism - Sulphur metabolism; PMID:8655516 192222003964 HMMPfam hit to PF05935, Arylsulfotransferase (ASST), score 8.2e-179 192222003965 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 192222003966 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 192222003967 catalytic residues [active] 192222003968 hinge region; other site 192222003969 alpha helical domain; other site 192222003970 HMMPfam hit to PF01323, DSBA-like thioredoxin domain, score 1.1e-05 192222003971 Cytochrome c [Energy production and conversion]; Region: COG3258 192222003972 Cytochrome c [Energy production and conversion]; Region: COG3258 192222003973 Cytochrome c; Region: Cytochrom_C; cl11414 192222003974 PS00190 Cytochrome c family heme-binding site signature 192222003975 PS00190 Cytochrome c family heme-binding site signature 192222003976 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 192222003977 DHH family; Region: DHH; pfam01368 192222003978 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 192222003979 FHIPEP family; Region: FHIPEP; pfam00771 192222003980 HMMPfam hit to PF00771, FHIPEP family, score 4.4e-295 192222003981 Rrf2 family protein; Region: rrf2_super; TIGR00738 192222003982 Helix-turn-helix domains; Region: HTH; cl00088 192222003983 HMMPfam hit to PF02082, Transcriptional regulator,score 3e-31 192222003984 PS01332 Uncharacterized protein family UPF0074 signature 192222003985 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 192222003986 16S/18S rRNA binding site [nucleotide binding]; other site 192222003987 S13e-L30e interaction site [polypeptide binding]; other site 192222003988 25S rRNA binding site [nucleotide binding]; other site 192222003989 HMMPfam hit to PF00312, Ribosomal protein S15,score 2.4e-33 192222003990 PS00362 Ribosomal protein S15 signature 192222003991 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 192222003992 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222003993 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 192222003994 HMMPfam hit to PF01580, FtsK/SpoIIIE family, score 8.5e-94 192222003995 PS00017 ATP/GTP-binding site motif A (P-loop) 192222003996 lagellar hook-associated protein FlgL; Provisional; Region: PRK14692 192222003997 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 192222003998 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 192222003999 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 1.8e-05 192222004000 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 192222004001 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222004002 Walker A/P-loop; other site 192222004003 ATP binding site [chemical binding]; other site 192222004004 Q-loop/lid; other site 192222004005 ABC transporter signature motif; other site 192222004006 Walker B; other site 192222004007 D-loop; other site 192222004008 H-loop/switch region; other site 192222004009 ABC transporter; Region: ABC_tran_2; pfam12848 192222004010 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 192222004011 HMMPfam hit to PF00005, ABC transporter, score 2.1e-45 192222004012 PS00211 ABC transporters family signature 192222004013 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004014 HMMPfam hit to PF00005, ABC transporter, score 7.2e-43 192222004015 PS00211 ABC transporters family signature 192222004016 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004017 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 192222004018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 192222004019 ATP binding site [chemical binding]; other site 192222004020 Mg2+ binding site [ion binding]; other site 192222004021 G-X-G motif; other site 192222004022 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.5e-20 192222004023 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.3e-11 192222004024 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 192222004025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 192222004026 active site 192222004027 phosphorylation site [posttranslational modification] 192222004028 intermolecular recognition site; other site 192222004029 dimerization interface [polypeptide binding]; other site 192222004030 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 192222004031 DNA binding site [nucleotide binding] 192222004032 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 3.4e-18 192222004033 HMMPfam hit to PF00072, Response regulator receiver domain, score 5.5e-25 192222004034 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 192222004035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222004036 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 192222004037 putative L-serine binding site [chemical binding]; other site 192222004038 HMMPfam hit to PF01842, ACT domain, score 1.1e-11 192222004039 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 5.9e-52 192222004040 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2 192222004041 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature 192222004042 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 2.1e-20 192222004043 1 probable transmembrane helix predicted for Cj0892c by TMHMM2.0 at aa 7-26 192222004044 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 192222004045 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 192222004046 RNA binding site [nucleotide binding]; other site 192222004047 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 192222004048 RNA binding site [nucleotide binding]; other site 192222004049 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 192222004050 RNA binding site [nucleotide binding]; other site 192222004051 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 192222004052 RNA binding site [nucleotide binding]; other site 192222004053 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 192222004054 RNA binding site [nucleotide binding]; other site 192222004055 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 192222004056 RNA binding site [nucleotide binding]; other site 192222004057 HMMPfam hit to PF00575, S1 RNA binding domain,score 4.8e-15 192222004058 HMMPfam hit to PF00575, S1 RNA binding domain,score 3.1e-25 192222004059 HMMPfam hit to PF00575, S1 RNA binding domain,score 1.9e-27 192222004060 HMMPfam hit to PF00575, S1 RNA binding domain,score 5.7e-22 192222004061 HMMPfam hit to PF00575, S1 RNA binding domain,score 1.8e-06 192222004062 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 192222004063 LytB protein; Region: LYTB; cl00507 192222004064 HMMPfam hit to PF02401, LytB protein, score 2.5e-160 192222004065 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 192222004066 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 192222004067 hinge; other site 192222004068 active site 192222004069 HMMPfam hit to PF00275, EPSP synthase (3-phosphoshikimate 1-car, score 2.1e-163 192222004070 PS00104 EPSP synthase signature 1 192222004071 phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472 192222004072 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 192222004073 putative tRNA-binding site [nucleotide binding]; other site 192222004074 B3/4 domain; Region: B3_4; cl11458 192222004075 tRNA synthetase B5 domain; Region: B5; cl08394 192222004076 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 192222004077 dimer interface [polypeptide binding]; other site 192222004078 motif 1; other site 192222004079 motif 3; other site 192222004080 motif 2; other site 192222004081 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 192222004082 HMMPfam hit to PF03147, Ferredoxin-fold anticodon binding domain, score 4.8e-19 192222004083 HMMPfam hit to PF03484, tRNA synthetase B5 domain,score 2.7e-21 192222004084 HMMPfam hit to PF03483, B3/4 domain, score 5.4e-21 192222004085 HMMPfam hit to PF01588, tRNA binding domain, score 2.9e-27 192222004086 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 192222004087 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 192222004088 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 192222004089 dimer interface [polypeptide binding]; other site 192222004090 motif 1; other site 192222004091 active site 192222004092 motif 2; other site 192222004093 motif 3; other site 192222004094 HMMPfam hit to PF01409, tRNA synthetases class II core domain, score 7.2e-143 192222004095 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 192222004096 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 192222004097 HMMPfam hit to PF02912, Aminoacyl tRNA synthetase class II, N, score 2.5e-23 192222004098 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 192222004099 nucleotide binding site/active site [active] 192222004100 HIT family signature motif; other site 192222004101 catalytic residue [active] 192222004102 HMMPfam hit to PF01230, HIT domain, score 3.2e-40 192222004103 DJ-1 family protein; Region: not_thiJ; TIGR01383 192222004104 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 192222004105 conserved cys residue [active] 192222004106 HMMPfam hit to PF01965, DJ-1/PfpI family, score 6.9e-32 192222004107 PS00225 Crystallins beta and gamma 'Greek key' motif signature 192222004108 1 probable transmembrane helix predicted for Cj0900c by TMHMM2.0 at aa 10-32 192222004109 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 192222004110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 192222004111 dimer interface [polypeptide binding]; other site 192222004112 conserved gate region; other site 192222004113 putative PBP binding loops; other site 192222004114 ABC-ATPase subunit interface; other site 192222004115 4 probable transmembrane helices predicted for Cj0901 by TMHMM2.0 at aa 5-27, 54-76, 100-122 and 217-236 192222004116 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.6e-34 192222004117 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004118 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign 192222004119 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 192222004120 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 192222004121 Walker A/P-loop; other site 192222004122 ATP binding site [chemical binding]; other site 192222004123 Q-loop/lid; other site 192222004124 ABC transporter signature motif; other site 192222004125 Walker B; other site 192222004126 D-loop; other site 192222004127 H-loop/switch region; other site 192222004128 HMMPfam hit to PF00005, ABC transporter, score 2.6e-56 192222004129 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004130 PS00211 ABC transporters family signature 192222004131 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 192222004132 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 192222004133 HMMPfam hit to PF01235, Sodium:alanine symporter family, score 4.2e-138 192222004134 PS00873 Sodium:alanine symporter family signature 192222004135 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 192222004136 HMMPfam hit to PF00588, SpoU rRNA Methylase family,score 9.5e-32 192222004137 alanine racemase; Reviewed; Region: alr; PRK00053 192222004138 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 192222004139 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 192222004140 catalytic residue [active] 192222004141 HMMPfam hit to PF00842, Alanine racemase,C-terminal domain, score 6.9e-39 192222004142 HMMPfam hit to PF01168, Alanine racemase,N-terminal domain, score 6.2e-57 192222004143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 192222004144 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 192222004145 1 probable transmembrane helix predicted for Cj0908 by TMHMM2.0 at aa 5-23 192222004146 Protein of unknown function (DUF461); Region: DUF461; cl01071 192222004147 HMMPfam hit to PF04314, Protein of unknown function (DUF461), score 1.3e-62 192222004148 1 probable transmembrane helix predicted for Cj0910 by TMHMM2.0 at aa 4-26 192222004149 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 192222004150 Cu(I) binding site [ion binding]; other site 192222004151 1 probable transmembrane helix predicted for Cj0911 by TMHMM2.0 at aa 5-22 192222004152 HMMPfam hit to PF02630, SCO1/SenC, score 2.3e-09 192222004153 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 192222004154 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 192222004155 dimer interface [polypeptide binding]; other site 192222004156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222004157 catalytic residue [active] 192222004158 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 2.3e-116 192222004159 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site 192222004160 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site 192222004161 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 192222004162 IHF dimer interface [polypeptide binding]; other site 192222004163 IHF - DNA interface [nucleotide binding]; other site 192222004164 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 1.9e-42 192222004165 PS00142 Neutral zinc metallopeptidases,zinc-binding region signature 192222004166 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 192222004167 HMMPfam hit to PF03061, Thioesterase superfamily,score 7.8e-17 192222004168 Protein of unknown function (DUF466); Region: DUF466; cl01082 192222004169 HMMPfam hit to PF04328, Protein of unknown function (DUF466), score 1.2e-39 192222004170 carbon starvation protein A; Provisional; Region: PRK15015 192222004171 Carbon starvation protein CstA; Region: CstA; pfam02554 192222004172 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 192222004173 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004174 HMMPfam hit to PF02554, Carbon starvation protein CstA, score 3.2e-248 192222004175 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004176 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004177 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 192222004178 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 192222004179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 192222004180 active site 192222004181 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 2.6e-35 192222004182 PS00103 Purine/pyrimidine phosphoribosyl transferases signature 192222004183 PS00114 Phosphoribosyl pyrophosphate synthetase signature 192222004184 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 192222004185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 192222004186 dimer interface [polypeptide binding]; other site 192222004187 conserved gate region; other site 192222004188 putative PBP binding loops; other site 192222004189 ABC-ATPase subunit interface; other site 192222004190 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 7.4e-18 192222004191 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign 192222004192 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 192222004194 dimer interface [polypeptide binding]; other site 192222004195 conserved gate region; other site 192222004196 putative PBP binding loops; other site 192222004197 ABC-ATPase subunit interface; other site 192222004198 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.2e-24 192222004199 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign 192222004200 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 192222004201 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 192222004202 substrate binding pocket [chemical binding]; other site 192222004203 membrane-bound complex binding site; other site 192222004204 hinge residues; other site 192222004205 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 5.3e-41 192222004206 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature 192222004207 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 192222004208 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 192222004209 Walker A/P-loop; other site 192222004210 ATP binding site [chemical binding]; other site 192222004211 Q-loop/lid; other site 192222004212 ABC transporter signature motif; other site 192222004213 Walker B; other site 192222004214 D-loop; other site 192222004215 H-loop/switch region; other site 192222004216 HMMPfam hit to PF00005, ABC transporter, score 1.3e-64 192222004217 PS00211 ABC transporters family signature 192222004218 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004219 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 192222004220 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 192222004221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222004222 HMMPfam hit to PF01739, CheR methyltransferase, SAM binding domain, score 5.3e-73 192222004223 HMMPfam hit to PF03705, CheR methyltransferase,all-alpha domain, score 3e-12 192222004224 CheB methylesterase; Region: CheB_methylest; pfam01339 192222004225 HMMPfam hit to PF01339, CheB methylesterase, score 7.1e-18 192222004226 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 192222004227 HMMPfam hit to PF02502, Ribose/Galactose Isomerase,score 2.4e-46 192222004228 PS00237 G-protein coupled receptors signature 192222004229 PS00190 Cytochrome c family heme-binding site signature 192222004230 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 192222004231 TSC-22/dip/bun family; Region: TSC22; cl01853 192222004232 1 probable transmembrane helix predicted for Cj0926 by TMHMM2.0 at aa 5-24 192222004233 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 192222004234 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 192222004235 active site 192222004236 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 1.6e-41 192222004237 PS00030 Eukaryotic RNA-binding region RNP-1 signature 192222004238 PS00103 Purine/pyrimidine phosphoribosyl transferases signature 192222004239 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 192222004240 5 probable transmembrane helices predicted for Cj0928 by TMHMM2.0 at aa 15-37, 44-66, 86-108, 128-150 and 165-183 192222004241 HMMPfam hit to PF00597, DedA family, score 2.4e-10 192222004242 multifunctional aminopeptidase A; Provisional; Region: PRK00913 192222004243 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 192222004244 interface (dimer of trimers) [polypeptide binding]; other site 192222004245 Substrate-binding/catalytic site; other site 192222004246 Zn-binding sites [ion binding]; other site 192222004247 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature 192222004248 HMMPfam hit to PF00883, Cytosol aminopeptidase family, catalyti, score 5.3e-159 192222004249 PS00631 Cytosol aminopeptidase signature 192222004250 GTP-binding protein YchF; Reviewed; Region: PRK09601 192222004251 YchF GTPase; Region: YchF; cd01900 192222004252 G1 box; other site 192222004253 GTP/Mg2+ binding site [chemical binding]; other site 192222004254 Switch I region; other site 192222004255 G2 box; other site 192222004256 Switch II region; other site 192222004257 G3 box; other site 192222004258 G4 box; other site 192222004259 G5 box; other site 192222004260 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 192222004261 HMMPfam hit to PF01926, GTPase of unknown function,score 2.2e-34 192222004262 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004263 HMMPfam hit to PF06071, Protein of unknown function (DUF933), score 8.1e-60 192222004264 argininosuccinate lyase; Provisional; Region: PRK00855 192222004265 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 192222004266 active sites [active] 192222004267 tetramer interface [polypeptide binding]; other site 192222004268 HMMPfam hit to PF00206, Lyase, score 5.1e-88 192222004269 PS00163 Fumarate lyases signature 192222004270 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 192222004271 active site 192222004272 substrate-binding site [chemical binding]; other site 192222004273 metal-binding site [ion binding] 192222004274 ATP binding site [chemical binding]; other site 192222004275 HMMPfam hit to PF01293, Phosphoenolpyruvate carboxykinase, score 1.7e-302 192222004276 PS00532 Phosphoenolpyruvate carboxykinase (ATP) signature 192222004277 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004278 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 192222004279 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 192222004280 active site 192222004281 catalytic residues [active] 192222004282 metal binding site [ion binding]; metal-binding site 192222004283 homodimer binding site [polypeptide binding]; other site 192222004284 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 192222004285 carboxyltransferase (CT) interaction site; other site 192222004286 biotinylation site [posttranslational modification]; other site 192222004287 HMMPfam hit to PF00364, Biotin-requiring enzyme,score 2e-19 192222004288 PS00188 Biotin-requiring enzymes attachment site 192222004289 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 192222004290 HMMPfam hit to PF00209, Sodium:neurotransmitter symporter family, score 3.5e-08 192222004291 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004292 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 192222004293 HMMPfam hit to PF00209, Sodium:neurotransmitter symporter family, score 2.2e-10 192222004294 ATP synthase subunit C; Region: ATP-synt_C; cl00466 192222004295 3 probable transmembrane helices predicted for Cj0936 by TMHMM2.0 at aa 5-24, 39-61 and 82-104 192222004296 HMMPfam hit to PF00137, ATP synthase subunit C,score 3.8e-19 192222004297 PS00605 ATP synthase c subunit signature 192222004298 Membrane transport protein; Region: Mem_trans; cl09117 192222004299 HMMPfam hit to PF03547, Auxin Efflux Carrier, score 1.1e-81 192222004300 10 probable transmembrane helices predicted for Cj0937 by TMHMM2.0 at aa 4-26, 31-48, 58-80, 93-115,125-147, 168-187, 192-214, 221-243, 253-271 and 278-300 192222004301 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004302 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004303 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 192222004304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 192222004305 putative substrate translocation pore; other site 192222004306 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 192222004307 putative acyl-acceptor binding pocket; other site 192222004308 AMP-binding enzyme; Region: AMP-binding; cl15778 192222004309 HMMPfam hit to PF00501, AMP-binding enzyme, score 1e-63 192222004310 PS00455 AMP-binding domain signature 192222004311 HMMPfam hit to PF01553, Acyltransferase, score 3.3e-22 192222004312 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3e-18 192222004313 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004314 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 192222004315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 192222004316 dimer interface [polypeptide binding]; other site 192222004317 conserved gate region; other site 192222004318 putative PBP binding loops; other site 192222004319 ABC-ATPase subunit interface; other site 192222004320 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.8e-27 192222004321 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign 192222004322 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 192222004323 FtsX-like permease family; Region: FtsX; cl15850 192222004324 HMMPfam hit to PF02687, Predicted permease, score 7.2e-44 192222004325 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 192222004326 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222004327 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 192222004328 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 192222004329 nucleotide binding region [chemical binding]; other site 192222004330 ATP-binding site [chemical binding]; other site 192222004331 SEC-C motif; Region: SEC-C; pfam02810 192222004332 HMMPfam hit to PF02810, SEC-C motif, score 3.7e-09 192222004333 HMMPfam hit to PF07516, SecA Wing and Scaffold domain, score 2.8e-73 192222004334 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 0.002 192222004335 HMMPfam hit to PF07517, SecA DEAD-like domain,score 5.8e-153 192222004336 HMMPfam hit to PF01043, SecA preprotein cross-linking domain, score 6.2e-69 192222004337 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 192222004338 PIF1-like helicase; Region: PIF1; pfam05970 192222004339 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 192222004340 Helicase; Region: Herpes_Helicase; pfam02689 192222004341 1 probable transmembrane helix predicted for Cj0945c by TMHMM2.0 at aa 41-63 192222004342 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004343 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 192222004344 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 192222004345 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 192222004346 NlpC/P60 family; Region: NLPC_P60; cl11438 192222004347 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004348 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 192222004349 Predicted amidohydrolase [General function prediction only]; Region: COG0388 192222004350 putative active site; other site 192222004351 catalytic triad [active] 192222004352 putative dimer interface [polypeptide binding]; other site 192222004353 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase,score 2.2e-59 192222004354 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 192222004355 Cation efflux family; Region: Cation_efflux; cl00316 192222004356 HMMPfam hit to PF01545, Cation efflux family, score 5.9e-101 192222004357 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 192222004358 HMMPfam hit to PF04371, Porphyromonas-type peptidyl-arginine deimin, score 6.5e-166 192222004359 META domain; Region: META; cl01245 192222004360 HMMPfam hit to PF03724, Domain of unknown function (306), score 1.5e-33 192222004361 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004362 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 192222004363 dimer interface [polypeptide binding]; other site 192222004364 putative CheW interface [polypeptide binding]; other site 192222004365 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 3.3e-07 192222004366 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 192222004367 PS00190 Cytochrome c family heme-binding site signature 192222004368 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 192222004369 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 192222004370 purine monophosphate binding site [chemical binding]; other site 192222004371 dimer interface [polypeptide binding]; other site 192222004372 putative catalytic residues [active] 192222004373 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 192222004374 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 192222004375 HMMPfam hit to PF01808, AICARFT/IMPCHase bienzyme,score 1.3e-86 192222004376 HMMPfam hit to PF02142, MGS-like domain, score 3.8e-53 192222004377 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 192222004378 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 192222004379 putative metal binding site [ion binding]; other site 192222004380 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 192222004381 HSP70 interaction site [polypeptide binding]; other site 192222004382 HMMPfam hit to PF00226, DnaJ domain, score 9e-11 192222004383 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 192222004384 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 192222004385 dimerization interface [polypeptide binding]; other site 192222004386 ATP binding site [chemical binding]; other site 192222004387 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 192222004388 dimerization interface [polypeptide binding]; other site 192222004389 ATP binding site [chemical binding]; other site 192222004390 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 2.5e-09 192222004391 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 6.5e-29 192222004392 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 6.6e-47 192222004393 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 4.9e-39 192222004394 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 192222004395 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 192222004396 trmE is a tRNA modification GTPase; Region: trmE; cd04164 192222004397 G1 box; other site 192222004398 GTP/Mg2+ binding site [chemical binding]; other site 192222004399 Switch I region; other site 192222004400 G2 box; other site 192222004401 Switch II region; other site 192222004402 G3 box; other site 192222004403 G4 box; other site 192222004404 G5 box; other site 192222004405 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 192222004406 HMMPfam hit to PF01926, GTPase of unknown function,score 1.7e-44 192222004407 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004408 membrane protein insertase; Provisional; Region: PRK01318 192222004409 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 192222004410 HMMPfam hit to PF02096, 60Kd inner membrane protein, score 1.1e-110 192222004411 Haemolytic domain; Region: Haemolytic; cl00506 192222004412 HMMPfam hit to PF01809, Domain of unknown function DUF37, score 6e-25 192222004413 Ribonuclease P; Region: Ribonuclease_P; cl00457 192222004414 HMMPfam hit to PF00825, Ribonuclease P, score 2.6e-15 192222004415 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 192222004416 HMMPfam hit to PF00468, Ribosomal protein L34,score 2.7e-18 192222004417 PS00784 Ribosomal protein L34 signature 192222004418 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 192222004419 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 192222004420 Coenzyme A binding pocket [chemical binding]; other site 192222004421 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.8e-13 192222004422 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 192222004423 ligand binding site [chemical binding]; other site 192222004424 active site 192222004425 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 192222004426 active site 192222004427 HMMPfam hit to PF03061, Thioesterase superfamily,score 1.4e-18 192222004428 PS01328 4-hydroxybenzoyl-CoA thioesterase family active site 192222004429 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site 192222004430 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature 192222004431 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004432 Original (2000) note: Cj0968, probable periplasmic protein, len: 80 aa; no Hp match. Contains probable N-terminal signal sequence. Similar to N-terminus of Cj0737 (53.3% identity in 92 aa overlap). The similarity continues in Cj0968, suggesting that this may be the start of a pseudogene; Original (2000) note: Cj0969, probable pseudogene,len 132 bp; 65.4% identical to part of Cj0737, similarity continues from upstream ORF. No Hp match; Updated (2006) note: No specific characterisation with acceptable identity scores has been carried out yet. Thus, kept within product function. Coding sequence has been updated to reflect the complete amino acid sequence for the encoded protein regardless of its expression. This will cause differences from the amino acid sequence of the previous annotation. Functional classification - Miscellaneous periplasmic proteins 192222004433 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 192222004434 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 192222004435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 192222004436 S-adenosylmethionine binding site [chemical binding]; other site 192222004437 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 192222004438 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004439 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 192222004440 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 192222004441 Catalytic site; other site 192222004442 HMMPfam hit to PF00565, Staphylococcal nuclease homologue, score 1.3e-34 192222004443 1 probable transmembrane helix predicted for Cj0979c by TMHMM2.0 at aa 21-39 192222004444 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 192222004445 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 192222004446 metal binding site [ion binding]; metal-binding site 192222004447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 192222004448 metabolite-proton symporter; Region: 2A0106; TIGR00883 192222004449 putative substrate translocation pore; other site 192222004450 HMMPfam hit to PF00083, Sugar (and other) transporter, score 6.5e-10 192222004451 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004452 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.8e-19 192222004453 PS00216 Sugar transport proteins signature 1 192222004454 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 192222004455 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 192222004456 substrate binding pocket [chemical binding]; other site 192222004457 membrane-bound complex binding site; other site 192222004458 hinge residues; other site 192222004459 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 4.6e-53 192222004460 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004461 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004462 Protein of unknown function (DUF328); Region: DUF328; cl01143 192222004463 HMMPfam hit to PF03883, Protein of unknown function (DUF328), score 1.8e-128 192222004464 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 192222004465 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 192222004466 metal binding site [ion binding]; metal-binding site 192222004467 putative dimer interface [polypeptide binding]; other site 192222004468 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 8.8e-44 192222004469 PS00881 Protein splicing signature 192222004470 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 3.8e-12 192222004471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 192222004472 putative substrate translocation pore; other site 192222004473 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 7.7e-16 192222004474 1 probable transmembrane helix predicted for Cj0988c by TMHMM2.0 at aa 25-42 192222004475 1 probable transmembrane helix predicted for Cj0989 by TMHMM2.0 at aa 4-21 192222004476 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 192222004477 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 192222004478 Cysteine-rich domain; Region: CCG; pfam02754 192222004479 Cysteine-rich domain; Region: CCG; pfam02754 192222004480 HMMPfam hit to PF02754, Cysteine-rich domain, score 2.4e-11 192222004481 HMMPfam hit to PF02754, Cysteine-rich domain, score 6.7e-10 192222004482 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.0013 192222004483 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222004484 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 192222004485 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 192222004486 FeS/SAM binding site; other site 192222004487 HemN C-terminal domain; Region: HemN_C; pfam06969 192222004488 HMMPfam hit to PF06969, HemN C-terminal region,score 6.8e-41 192222004489 HMMPfam hit to PF04055, Radical SAM superfamily,score 3.5e-26 192222004490 Protein of unknown function (DUF2603); Region: DUF2603; pfam10788 192222004491 ornithine carbamoyltransferase; Provisional; Region: PRK00779 192222004492 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 192222004493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222004494 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, As, score 4.8e-46 192222004495 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, ca, score 3.9e-67 192222004496 PS00097 Aspartate and ornithine carbamoyltransferases signature 192222004497 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 192222004498 dimer interface [polypeptide binding]; other site 192222004499 active site 192222004500 Schiff base residues; other site 192222004501 HMMPfam hit to PF00490, Delta-aminolevulinic acid dehydratase, score 2e-176 192222004502 PS00169 Delta-aminolevulinic acid dehydratase active site 192222004503 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 192222004504 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 192222004505 dimerization interface [polypeptide binding]; other site 192222004506 active site 192222004507 HMMPfam hit to PF00925, GTP cyclohydrolase II,score 7e-67 192222004508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 192222004509 HMMPfam hit to PF02527, Glucose inhibited division protein, score 1.4e-21 192222004510 PS00294 Prenyl group binding site (CAAX box) 192222004511 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 192222004512 HMMPfam hit to PF03601, Conserved hypothetical protein, score 3.7e-156 192222004513 Transcriptional regulator [Transcription]; Region: LysR; COG0583 192222004514 Helix-turn-helix domains; Region: HTH; cl00088 192222004515 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 192222004516 dimerization interface [polypeptide binding]; other site 192222004517 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 7e-15 192222004518 HMMPfam hit to PF03466, LysR substrate binding domain, score 7.7e-23 192222004519 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 192222004520 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 192222004521 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 192222004522 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 192222004523 DNA binding residues [nucleotide binding] 192222004524 HMMPfam hit to PF00140, Sigma-70 factor, region,score 8.5e-15 192222004525 HMMPfam hit to PF04546, Sigma-70, non-essential region, score 0.01 192222004526 HMMPfam hit to PF04542, Sigma-70 region, score 6.2e-28 192222004527 PS00715 Sigma-70 factors family signature 1 192222004528 HMMPfam hit to PF04539, Sigma-70 region, score 5.3e-35 192222004529 HMMPfam hit to PF04545, Sigma-70, region, score 7.3e-19 192222004530 PS00716 Sigma-70 factors family signature 2 192222004531 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 192222004532 catalytic core [active] 192222004533 Rhomboid family; Region: Rhomboid; cl11446 192222004534 HMMPfam hit to PF01694, Rhomboid family, score 2.2e-38 192222004535 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 192222004536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 192222004537 Walker A motif; other site 192222004538 ATP binding site [chemical binding]; other site 192222004539 Walker B motif; other site 192222004540 arginine finger; other site 192222004541 HMMPfam hit to PF01434, Peptidase family M41, score 0.00033 192222004542 HMMPfam hit to PF00004, ATPase family associated with various c, score 3.2e-83 192222004543 PS00674 AAA-protein family signature 192222004544 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004545 HMMPfam hit to PF06480, FtsH Extracellular, score 5e-36 192222004546 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 192222004547 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 192222004548 HMMPfam hit to PF04055, Radical SAM superfamily,score 1.5e-18 192222004549 PS01278 Uncharacterized protein family UPF0004 signature 192222004550 HMMPfam hit to PF00919, Uncharacterized protein family UPF0004, score 8.5e-21 192222004551 Mitotic checkpoint protein; Region: MAD; pfam05557 192222004552 Mechanosensitive ion channel; Region: MS_channel; pfam00924 192222004553 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 1.1e-24 192222004554 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 192222004555 active site 192222004556 dimer interface [polypeptide binding]; other site 192222004557 metal binding site [ion binding]; metal-binding site 192222004558 HMMPfam hit to PF01761, 3-dehydroquinate synthase,score 7.1e-147 192222004559 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3400 192222004561 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 192222004562 HMMPfam hit to PF02080, TrkA-C domain, score 2.6e-11 192222004563 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 192222004564 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 192222004565 HMMPfam hit to PF01702, Queuine tRNA-ribosyltransferase, score 4.9e-110 192222004566 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 192222004567 2 probable transmembrane helices predicted for Cj1011 by TMHMM2.0 at aa 180-202 and 217-236 192222004568 1 probable transmembrane helix predicted for Cj1012c by TMHMM2.0 at aa 4-23 192222004569 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 192222004570 ResB-like family; Region: ResB; pfam05140 192222004571 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 192222004572 HMMPfam hit to PF01578, Cytochrome C assembly protein, score 3.8e-49 192222004573 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 192222004574 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 192222004575 Walker A/P-loop; other site 192222004576 ATP binding site [chemical binding]; other site 192222004577 Q-loop/lid; other site 192222004578 ABC transporter signature motif; other site 192222004579 Walker B; other site 192222004580 D-loop; other site 192222004581 H-loop/switch region; other site 192222004582 HMMPfam hit to PF00005, ABC transporter, score 1.7e-42 192222004583 PS00211 ABC transporters family signature 192222004584 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004585 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 192222004586 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 192222004587 Walker A/P-loop; other site 192222004588 ATP binding site [chemical binding]; other site 192222004589 Q-loop/lid; other site 192222004590 ABC transporter signature motif; other site 192222004591 Walker B; other site 192222004592 D-loop; other site 192222004593 H-loop/switch region; other site 192222004594 HMMPfam hit to PF00005, ABC transporter, score 1.5e-57 192222004595 PS00211 ABC transporters family signature 192222004596 PS00063 Aldo/keto reductase family active site signature 192222004597 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004598 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 192222004599 TM-ABC transporter signature motif; other site 192222004600 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 1.8e-32 192222004601 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 192222004602 TM-ABC transporter signature motif; other site 192222004603 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 1e-38 192222004604 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004605 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 192222004606 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 192222004607 putative ligand binding site [chemical binding]; other site 192222004608 HMMPfam hit to PF01094, Receptor family ligand binding region, score 3.8e-49 192222004609 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 192222004610 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 192222004611 putative ligand binding site [chemical binding]; other site 192222004612 HMMPfam hit to PF01094, Receptor family ligand binding region, score 1.3e-52 192222004613 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide 192222004614 Cytochrome c; Region: Cytochrom_C; cl11414 192222004615 HMMPfam hit to PF00034, Cytochrome c, score 0.0087 192222004616 PS00190 Cytochrome c family heme-binding site signature 192222004617 1 probable transmembrane helix predicted for Cj1020c by TMHMM2.0 at aa 5-27 192222004618 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 192222004619 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 192222004620 HMMPfam hit to PF07053, Protein of unknown function (DUF1334), score 3e-81 192222004621 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 192222004622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222004623 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 192222004624 HMMPfam hit to PF02774, Semialdehyde dehydrogenase,dimerisat, score 6.2e-88 192222004625 PS01103 Aspartate-semialdehyde dehydrogenase signature 192222004626 HMMPfam hit to PF01118, Semialdehyde dehydrogenase,NAD bindi, score 5.8e-59 192222004627 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 192222004628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 192222004629 active site 192222004630 phosphorylation site [posttranslational modification] 192222004631 intermolecular recognition site; other site 192222004632 dimerization interface [polypeptide binding]; other site 192222004633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 192222004634 Walker A motif; other site 192222004635 ATP binding site [chemical binding]; other site 192222004636 Walker B motif; other site 192222004637 arginine finger; other site 192222004638 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 9.7e-136 192222004639 PS00676 Sigma-54 interaction domain ATP-binding region B signature 192222004640 PS00675 Sigma-54 interaction domain ATP-binding region A signature 192222004641 HMMPfam hit to PF00072, Response regulator receiver domain, score 9.1e-27 192222004642 LPP20 lipoprotein; Region: LPP20; cl15824 192222004643 HMMPfam hit to PF04164, Protein of unknown function, DUF400, score 3.2e-61 192222004644 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004645 DNA gyrase subunit A; Validated; Region: PRK05560 192222004646 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 192222004647 CAP-like domain; other site 192222004648 active site 192222004649 primary dimer interface [polypeptide binding]; other site 192222004650 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 192222004651 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 192222004652 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 192222004653 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 192222004654 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 192222004655 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 9.4e-11 192222004656 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 1.4e-15 192222004657 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 2.1e-15 192222004658 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 2.4e-14 192222004659 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 5.4e-15 192222004660 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 4.8e-14 192222004661 HMMPfam hit to PF00521, DNA gyrase/topoisomerase IV, subunit A, score 0 192222004662 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 192222004663 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 192222004664 active site 192222004665 PS00103 Purine/pyrimidine phosphoribosyl transferases signature 192222004666 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 192222004667 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004668 GTP-binding protein LepA; Provisional; Region: PRK05433 192222004669 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 192222004670 G1 box; other site 192222004671 putative GEF interaction site [polypeptide binding]; other site 192222004672 GTP/Mg2+ binding site [chemical binding]; other site 192222004673 Switch I region; other site 192222004674 G2 box; other site 192222004675 G3 box; other site 192222004676 Switch II region; other site 192222004677 G4 box; other site 192222004678 G5 box; other site 192222004679 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 192222004680 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 192222004681 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 192222004682 HMMPfam hit to PF06421, GTP-binding protein LepA C-terminus, score 1.2e-74 192222004683 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 3.7e-39 192222004684 HMMPfam hit to PF03144, Elongation factor Tu domain, score 1.2e-10 192222004685 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 5.1e-73 192222004686 PS00301 GTP-binding elongation factors signature 192222004687 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004688 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 192222004689 HMMPfam hit to PF02321, Outer membrane efflux protein, score 3.8e-05 192222004690 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.3e-11 192222004691 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 192222004692 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 192222004693 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 192222004694 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family,score 5.6e-198 192222004695 12 probable transmembrane helices predicted for Cj1033 by TMHMM2.0 at aa 12-34, 319-338, 345-367, 372-394,415-437, 452-474, 508-530, 829-851, 856-878, 883-905,931-953 and 963-985 192222004696 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004697 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 192222004698 HSP70 interaction site [polypeptide binding]; other site 192222004699 HMMPfam hit to PF00226, DnaJ domain, score 1.5e-05 192222004700 Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935 192222004701 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 192222004702 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 192222004703 HMMPfam hit to PF04377, Arginine-tRNA-protein transferase, C terminu, score 7.3e-72 192222004704 HMMPfam hit to PF04376, Arginine-tRNA-protein transferase, N terminu, score 1.9e-42 192222004705 acetyl-CoA carboxylase subunit A; Validated; Region: PRK08463 192222004706 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 192222004707 ATP-grasp domain; Region: ATP-grasp_4; cl03087 192222004708 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 192222004709 HMMPfam hit to PF02785, Biotin carboxylase C-terminal domain, score 7.6e-49 192222004710 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 2.9e-98 192222004711 PS00867 Carbamoyl-phosphate synthase subdomain signature 2 192222004712 PS00866 Carbamoyl-phosphate synthase subdomain signature 1 192222004713 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 1.3e-42 192222004714 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 192222004715 HMMPfam hit to PF01098, Cell cycle protein, score 6e-78 192222004716 10 probable transmembrane helices predicted for Cj1038 by TMHMM2.0 at aa 7-29, 39-58, 71-93, 103-125,145-164, 168-186, 191-208, 294-314, 326-348 and 358-380 192222004717 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 192222004718 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 192222004719 active site 192222004720 homodimer interface [polypeptide binding]; other site 192222004721 HMMPfam hit to PF03033, Glycosyltransferase family,score 1.4e-14 192222004722 HMMPfam hit to PF04101, Glycosyltransferase family,score 1.2e-40 192222004723 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 192222004724 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.2e-14 192222004725 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004726 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004727 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 192222004728 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 192222004729 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 3.3e-11 192222004730 PS00041 Bacterial regulatory proteins, araC family signature 192222004731 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.096 192222004732 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 192222004733 thiamine phosphate binding site [chemical binding]; other site 192222004734 active site 192222004735 pyrophosphate binding site [ion binding]; other site 192222004736 thiazole biosynthesis protein ThiH; Region: thiH; TIGR02351 192222004737 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 192222004738 FeS/SAM binding site; other site 192222004739 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 192222004740 HMMPfam hit to PF06968, Biotin and Thiamin Synthesis associated d, score 1.4e-41 192222004741 HMMPfam hit to PF04055, Radical SAM superfamily,score 2.4e-10 192222004742 PS00030 Eukaryotic RNA-binding region RNP-1 signature 192222004743 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 192222004744 ThiS interaction site; other site 192222004745 putative active site [active] 192222004746 tetramer interface [polypeptide binding]; other site 192222004747 HMMPfam hit to PF05690, Thiazole biosynthesis protein ThiG, score 8.9e-158 192222004748 ThiS-like ubiquitin; Region: ThiS-like; pfam14453 192222004749 thiamine biosynthesis protein ThiF, family 2; Region: thiF_fam2; TIGR02354 192222004750 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 192222004751 putative ATP binding site [chemical binding]; other site 192222004752 putative substrate interface [chemical binding]; other site 192222004753 HMMPfam hit to PF00899, ThiF family, score 4.1e-30 192222004754 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 192222004755 thiS-thiF/thiG interaction site; other site 192222004756 HMMPfam hit to PF02597, ThiS family, score 1.4e-12 192222004757 succinyl-diaminopimelate desuccinylase, proteobacterial clade; Region: dapE_proteo; TIGR01246 192222004758 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 192222004759 metal binding site [ion binding]; metal-binding site 192222004760 dimer interface [polypeptide binding]; other site 192222004761 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 1.5e-35 192222004762 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 9.4e-17 192222004763 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1 192222004764 LysE type translocator; Region: LysE; cl00565 192222004765 HMMPfam hit to PF01810, LysE type translocator,score 3.1e-59 192222004766 NAD-dependent deacetylase; Provisional; Region: PRK00481 192222004767 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 192222004768 HMMPfam hit to PF02146, Sir2 family, score 4.1e-40 192222004769 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 192222004770 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 192222004771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222004772 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 192222004773 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 192222004774 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 192222004775 HMMPfam hit to PF01420, Type I restriction modification DNA speci, score 8.2e-06 192222004776 HMMPfam hit to PF01420, Type I restriction modification DNA speci, score 4.8e-08 192222004777 PS00092 N-6 Adenine-specific DNA methylases signature 192222004778 PS00290 Immunoglobulins and major histocompatibility complex proteins signature 192222004779 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 192222004780 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222004781 Walker A/P-loop; other site 192222004782 ATP binding site [chemical binding]; other site 192222004783 Q-loop/lid; other site 192222004784 ABC transporter signature motif; other site 192222004785 Walker B; other site 192222004786 D-loop; other site 192222004787 H-loop/switch region; other site 192222004788 Smr domain; Region: Smr; cl02619 192222004789 HMMPfam hit to PF01713, Smr domain, score 2.2e-31 192222004790 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004791 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 192222004792 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 192222004793 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 192222004794 HMMPfam hit to PF02875, Mur ligase family,glutamate ligase doma, score 1.1e-24 192222004795 HMMPfam hit to PF01225, Mur ligase family,catalytic domain, score 6.5e-27 192222004796 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 192222004797 Sulfatase; Region: Sulfatase; cl10460 192222004798 HMMPfam hit to PF00884, Sulfatase, score 1.4e-94 192222004799 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004800 PS00044 Bacterial regulatory proteins, lysR family signature 192222004801 Predicted amidohydrolase [General function prediction only]; Region: COG0388 192222004802 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 192222004803 active site 192222004804 catalytic triad [active] 192222004805 dimer interface [polypeptide binding]; other site 192222004806 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 192222004807 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 192222004808 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 192222004809 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 192222004810 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 192222004811 active site 192222004812 HMMPfam hit to PF00478, IMP dehydrogenase / GMP reductase domain, score 4.6e-211 192222004813 PS00487 IMP dehydrogenase / GMP reductase signature 192222004814 HMMPfam hit to PF00571, CBS domain, score 4.4e-11 192222004815 HMMPfam hit to PF00571, CBS domain, score 1.3e-17 192222004816 Amidase; Region: Amidase; cl11426 192222004817 HMMPfam hit to PF01425, Amidase, score 4.2e-161 192222004818 PS00571 Amidases signature 192222004819 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004820 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004821 1 probable transmembrane helix predicted for Cj1060c by TMHMM2.0 at aa 10-29 192222004822 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 192222004823 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 192222004824 active site 192222004825 HIGH motif; other site 192222004826 nucleotide binding site [chemical binding]; other site 192222004827 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 192222004828 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 192222004829 active site 192222004830 KMSKS motif; other site 192222004831 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 192222004832 tRNA binding surface [nucleotide binding]; other site 192222004833 anticodon binding site; other site 192222004834 HMMPfam hit to PF06827, Zinc finger found in FPG and IleRS, score 0.0023 192222004835 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 0 192222004836 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature 192222004837 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 192222004838 Competence-damaged protein; Region: CinA; cl00666 192222004839 HMMPfam hit to PF02464, Competence-damaged protein,score 1.5e-28 192222004840 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 192222004841 Coenzyme A binding pocket [chemical binding]; other site 192222004842 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.1e-12 192222004843 Original (2000) note: Cj1064, possible nitroreductase pseudogene, len: 617 bp; similar to many e.g. YFKO_BACSU NAD(P)H nitroreductase YFKO (221 aa). Contains single frasemhift. Equivalent to HP0642, and similar to downstream (intact) gene Cj1066. Contains Pfam match to entry PF00881 Nitroreductase; Updated (2006) note: Characterised within Escherichia coli and Bacillus subtilus with acceptable identity scores. Thus, not added to product function. Coding sequence has been updated to reflect the complete amino acid sequence for the encoded protein regardless of its expression. This will cause differences from the amino acid sequence of the previous annotation. Functional classification - Misc; PMID:8947835, PMID:7813889 192222004844 HMMPfam hit to PF00881, Nitroreductase family,score 1.3e-32 192222004845 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 192222004846 dimer interface [polypeptide binding]; other site 192222004847 FMN binding site [chemical binding]; other site 192222004848 HMMPfam hit to PF00881, Nitroreductase family,score 2e-33 192222004849 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 192222004850 4 probable transmembrane helices predicted for Cj1067 by TMHMM2.0 at aa 7-24, 34-56, 77-99 and 141-163 192222004851 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 6.5e-30 192222004852 PS00379 CDP-alcohol phosphatidyltransferases signature 192222004853 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 192222004854 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 192222004855 active site 192222004856 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 192222004857 protein binding site [polypeptide binding]; other site 192222004858 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 192222004859 putative substrate binding region [chemical binding]; other site 192222004860 4 probable transmembrane helices predicted for Cj1068 by TMHMM2.0 at aa 7-29, 112-134, 291-313 and 338-360 192222004861 HMMPfam hit to PF02163, Peptidase family M50, score 1.2e-61 192222004862 PS00142 Neutral zinc metallopeptidases,zinc-binding region signature 192222004863 Protein of unknown function (DUF535); Region: DUF535; cl01128 192222004864 HMMPfam hit to PF04393, Protein of unknown function (DUF535), score 6.6e-134 192222004865 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 192222004866 HMMPfam hit to PF01250, Ribosomal protein S6, score 3.5e-37 192222004867 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 192222004868 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 192222004869 dimer interface [polypeptide binding]; other site 192222004870 ssDNA binding site [nucleotide binding]; other site 192222004871 tetramer (dimer of dimers) interface [polypeptide binding]; other site 192222004872 HMMPfam hit to PF00436, Single-strand binding protein family, score 6.3e-33 192222004873 PS00735 Single-strand binding protein family signature 1 192222004874 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 192222004875 HMMPfam hit to PF01084, Ribosomal protein S18,score 5.9e-25 192222004876 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 192222004877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 192222004878 Walker A motif; other site 192222004879 ATP binding site [chemical binding]; other site 192222004880 Walker B motif; other site 192222004881 arginine finger; other site 192222004882 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 192222004883 HMMPfam hit to PF05362, Lon protease (S16) C-terminal proteolytic do, score 3.7e-98 192222004884 PS01046 ATP-dependent serine proteases, lon family,serine active site 192222004885 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 6.4e-49 192222004886 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004887 HMMPfam hit to PF02190, ATP-dependent protease La (LON) domain, score 1.9e-06 192222004888 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 192222004889 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004890 FliW protein; Region: FliW; cl00740 192222004891 HMMPfam hit to PF02623, Uncharacterized BCR,COG1699, score 1.2e-36 192222004892 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 192222004893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222004894 HMMPfam hit to PF01089, Delta 1-pyrroline-5-carboxylate reductase, score 2.4e-44 192222004895 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004896 PS00521 Delta 1-pyrroline-5-carboxylate reductase signature 192222004897 1 probable transmembrane helix predicted for Cj1077 by TMHMM2.0 at aa 7-29 192222004898 1 probable transmembrane helix predicted for Cj1078 by TMHMM2.0 at aa 5-24 192222004899 PS00572 Glycosyl hydrolases family 1 active site 192222004900 1 probable transmembrane helix predicted for Cj1079 by TMHMM2.0 at aa 5-27 192222004901 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 192222004902 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 192222004903 active site 192222004904 HMMPfam hit to PF02602, Uroporphyrinogen-III synthase HemD, score 1.6e-06 192222004905 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 192222004906 thiamine phosphate binding site [chemical binding]; other site 192222004907 active site 192222004908 pyrophosphate binding site [ion binding]; other site 192222004909 HMMPfam hit to PF02581, Thiamine monophosphate synthase/TENI, score 1.5e-63 192222004910 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 192222004911 substrate binding site [chemical binding]; other site 192222004912 dimer interface [polypeptide binding]; other site 192222004913 ATP binding site [chemical binding]; other site 192222004914 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 192222004915 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 192222004916 minor groove reading motif; other site 192222004917 helix-hairpin-helix signature motif; other site 192222004918 active site 192222004919 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 2.7e-11 192222004920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 192222004921 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 192222004922 Walker A motif; other site 192222004923 ATP binding site [chemical binding]; other site 192222004924 Walker B motif; other site 192222004925 arginine finger; other site 192222004926 HMMPfam hit to PF05673, Protein of unknown function (DUF815), score 3.3e-60 192222004927 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004928 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 192222004929 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 192222004930 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 192222004931 ATP binding site [chemical binding]; other site 192222004932 putative Mg++ binding site [ion binding]; other site 192222004933 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 192222004934 nucleotide binding region [chemical binding]; other site 192222004935 ATP-binding site [chemical binding]; other site 192222004936 TRCF domain; Region: TRCF; cl04088 192222004937 HMMPfam hit to PF03461, TRCF domain, score 5.5e-31 192222004938 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.3e-15 192222004939 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 1.7e-25 192222004940 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004941 HMMPfam hit to PF02559, CarD-like/TRCF domain,score 4.1e-42 192222004942 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 192222004943 HMMPfam hit to PF04519, Protein of unknown function, DUF583, score 2.2e-48 192222004944 PS00430 TonB-dependent receptor proteins signature 1 192222004945 Peptidase family M23; Region: Peptidase_M23; pfam01551 192222004946 HMMPfam hit to PF01551, Peptidase family M23, score 1.8e-47 192222004947 1 probable transmembrane helix predicted for Cj1087c by TMHMM2.0 at aa 28-47 192222004948 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 192222004949 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 192222004950 Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as domain of unknown function 1 (DUF1). It is widely present in bacteria and often links to a wide range of non-homologous domains in...; Region: GGDEF; cl00291 192222004951 active site 192222004952 I-site; other site 192222004953 Lipopolysaccharide-assembly; Region: LptE; cl01125 192222004954 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004955 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 192222004956 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 192222004957 HIGH motif; other site 192222004958 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 192222004959 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 192222004960 active site 192222004961 KMSKS motif; other site 192222004962 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 192222004963 tRNA binding surface [nucleotide binding]; other site 192222004964 anticodon binding site; other site 192222004965 PS00017 ATP/GTP-binding site motif A (P-loop) 192222004966 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004967 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 7.4e-139 192222004968 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 192222004969 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 192222004970 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 192222004971 Protein export membrane protein; Region: SecD_SecF; cl14618 192222004972 HMMPfam hit to PF02355, Protein export membrane protein, score 9.9e-82 192222004973 HMMPfam hit to PF07549, SecD/SecF GG Motif, score 0.00022 192222004974 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 192222004975 Protein export membrane protein; Region: SecD_SecF; cl14618 192222004976 HMMPfam hit to PF02355, Protein export membrane protein, score 3.4e-06 192222004977 HMMPfam hit to PF07549, SecD/SecF GG Motif, score 0.00025 192222004978 Preprotein translocase subunit; Region: YajC; cl00806 192222004979 HMMPfam hit to PF02699, Preprotein translocase subunit, score 8.3e-40 192222004980 1 probable transmembrane helix predicted for Cj1094c by TMHMM2.0 at aa 5-24 192222004981 apolipoprotein N-acyltransferase; Reviewed; Region: PRK12291 192222004982 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 192222004983 active site 192222004984 catalytic triad [active] 192222004985 dimer interface [polypeptide binding]; other site 192222004986 7 probable transmembrane helices predicted for Cj1095 by TMHMM2.0 at aa 23-45, 49-68, 75-97, 101-123,128-145, 155-177 and 184-201 192222004987 S-adenosylmethionine synthetase; Validated; Region: PRK05250 192222004988 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 192222004989 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 192222004990 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 192222004991 HMMPfam hit to PF02773, S-adenosylmethionine synthetase, C-te, score 9e-51 192222004992 HMMPfam hit to PF02772, S-adenosylmethionine synthetase, cent, score 1e-22 192222004993 PS00376 S-adenosylmethionine synthetase signature 1 192222004994 HMMPfam hit to PF00438, S-adenosylmethionine synthetase, N-te, score 7.3e-25 192222004995 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 192222004996 9 probable transmembrane helices predicted for Cj1097 by TMHMM2.0 at aa 12-31, 41-63, 83-105, 139-161,182-201, 216-238, 245-267, 287-309 and 322-344 192222004997 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 4e-101 192222004998 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222004999 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222005000 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 192222005001 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 192222005002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222005003 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, ca, score 2.7e-47 192222005004 PS00097 Aspartate and ornithine carbamoyltransferases signature 192222005005 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, As, score 8.3e-14 192222005006 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 192222005007 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 192222005008 active site 192222005009 Zn binding site [ion binding]; other site 192222005010 HMMPfam hit to PF01432, Peptidase family M3, score 1.3e-73 192222005011 PS00142 Neutral zinc metallopeptidases,zinc-binding region signature 192222005012 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 192222005013 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222005014 Family description; Region: UvrD_C_2; cl15862 192222005015 HMMPfam hit to PF00580, UvrD/REP helicase, score 2.6e-149 192222005016 PS00017 ATP/GTP-binding site motif A (P-loop) 192222005017 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK04099 192222005018 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 192222005019 active site 192222005020 HMMPfam hit to PF01509, TruB family pseudouridylate synthase (N term, score 1.1e-25 192222005021 Global regulator protein family; Region: CsrA; cl00670 192222005022 HMMPfam hit to PF02599, Global regulator protein family, score 1.1e-31 192222005023 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181 192222005024 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 192222005025 HMMPfam hit to PF00288, GHMP kinases ATP-binding protei, score 1.2e-17 192222005026 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 192222005027 SmpB-tmRNA interface; other site 192222005028 HMMPfam hit to PF01668, SmpB protein, score 1.8e-35 192222005029 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 192222005030 catalytic residues [active] 192222005031 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 192222005032 HMMPfam hit to PF02617, ATP-dependent Clp protease adaptor protein C, score 2.9e-43 192222005033 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 192222005034 Clp amino terminal domain; Region: Clp_N; pfam02861 192222005035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 192222005036 Walker A motif; other site 192222005037 ATP binding site [chemical binding]; other site 192222005038 Walker B motif; other site 192222005039 arginine finger; other site 192222005040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 192222005041 Walker A motif; other site 192222005042 ATP binding site [chemical binding]; other site 192222005043 Walker B motif; other site 192222005044 arginine finger; other site 192222005045 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 192222005046 HMMPfam hit to PF02861, Clp amino terminal domain,score 3.7e-05 192222005047 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 9e-08 192222005048 PS00017 ATP/GTP-binding site motif A (P-loop) 192222005049 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 6e-80 192222005050 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 3.8e-05 192222005051 PS00017 ATP/GTP-binding site motif A (P-loop) 192222005052 PS00871 Chaperonins clpA/B signature 2 192222005053 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 192222005054 HMMPfam hit to PF03588, Leucyl/phenylalanyl-tRNA protein transf, score 9.3e-105 192222005055 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 192222005056 PAS domain; Region: PAS_9; pfam13426 192222005057 putative active site [active] 192222005058 heme pocket [chemical binding]; other site 192222005059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 192222005060 PAS domain; Region: PAS_9; pfam13426 192222005061 putative active site [active] 192222005062 heme pocket [chemical binding]; other site 192222005063 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 192222005064 dimer interface [polypeptide binding]; other site 192222005065 putative CheW interface [polypeptide binding]; other site 192222005066 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 2.9e-15 192222005067 HMMPfam hit to PF00785, PAC motif, score 5.7e-06 192222005068 HMMPfam hit to PF00785, PAC motif, score 0.11 192222005069 MarC family integral membrane protein; Region: MarC; cl00919 192222005070 HMMPfam hit to PF01914, MarC family integral membrane protein, score 1.4e-15 192222005071 methionine sulfoxide reductase B; Provisional; Region: PRK05508 192222005072 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 192222005073 HMMPfam hit to PF01641, SelR domain, score 1.8e-58 192222005074 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 192222005075 dinuclear metal binding motif [ion binding]; other site 192222005076 HMMPfam hit to PF04305, Protein of unknown function (DUF455), score 4.6e-167 192222005077 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 192222005078 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 192222005079 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 3.4e-23 192222005080 PS00379 CDP-alcohol phosphatidyltransferases signature 192222005081 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 192222005082 1 probable transmembrane helix predicted for Cj1115c by TMHMM2.0 at aa 10-44 192222005083 FtsH Extracellular; Region: FtsH_ext; pfam06480 192222005084 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 192222005085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 192222005086 Walker A motif; other site 192222005087 ATP binding site [chemical binding]; other site 192222005088 Walker B motif; other site 192222005089 arginine finger; other site 192222005090 Peptidase family M41; Region: Peptidase_M41; pfam01434 192222005091 HMMPfam hit to PF01434, Peptidase family M41, score 1.1e-86 192222005092 HMMPfam hit to PF00004, ATPase family associated with various c, score 3e-87 192222005093 PS00674 AAA-protein family signature 192222005094 PS00017 ATP/GTP-binding site motif A (P-loop) 192222005095 HMMPfam hit to PF06480, FtsH Extracellular, score 4.9e-38 192222005096 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 192222005097 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222005098 HMMPfam hit to PF06325, Ribosomal protein L11 methyltransferase (Prm, score 1.6e-22 192222005099 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 192222005100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 192222005101 active site 192222005102 phosphorylation site [posttranslational modification] 192222005103 intermolecular recognition site; other site 192222005104 dimerization interface [polypeptide binding]; other site 192222005105 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.7e-32 192222005106 Cache domain; Region: Cache_1; pfam02743 192222005107 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 192222005108 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 192222005109 NAD(P) binding site [chemical binding]; other site 192222005110 homodimer interface [polypeptide binding]; other site 192222005111 substrate binding site [chemical binding]; other site 192222005112 active site 192222005113 HMMPfam hit to PF02719, Polysaccharide biosynthesis protein, score 4e-140 192222005114 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 192222005115 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 192222005116 inhibitor-cofactor binding pocket; inhibition site 192222005117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222005118 catalytic residue [active] 192222005119 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 2e-75 192222005120 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 192222005121 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 192222005122 putative trimer interface [polypeptide binding]; other site 192222005123 putative CoA binding site [chemical binding]; other site 192222005124 HMMPfam hit to PF00132, no description, score 4 192222005125 HMMPfam hit to PF00132, no description, score 20 192222005126 HMMPfam hit to PF00132, no description, score 65 192222005127 Bacterial sugar transferase; Region: Bac_transf; cl00939 192222005128 HMMPfam hit to PF02397, Bacterial sugar transferase, score 1.8e-42 192222005129 1 probable transmembrane helix predicted for Cj1124c by TMHMM2.0 at aa 12-33 192222005130 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 192222005131 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 192222005132 putative ADP-binding pocket [chemical binding]; other site 192222005133 HMMPfam hit to PF00534, Glycosyl transferases group, score 3.3e-48 192222005134 Oligosaccharyl transferase STT3 subunit; Region: STT3; pfam02516 192222005135 HMMPfam hit to PF02516, Oligosaccharyl transferase STT3 subunit, score 1e-204 192222005136 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 192222005137 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 192222005138 putative ADP-binding pocket [chemical binding]; other site 192222005139 HMMPfam hit to PF00534, Glycosyl transferases group, score 4.1e-42 192222005140 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 192222005141 active site 192222005142 HMMPfam hit to PF00535, Glycosyl transferase, score 1.2e-41 192222005143 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 192222005144 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 192222005145 putative ADP-binding pocket [chemical binding]; other site 192222005146 HMMPfam hit to PF00534, Glycosyl transferases group, score 1e-47 192222005147 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 192222005148 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 192222005149 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222005150 Walker A/P-loop; other site 192222005151 ATP binding site [chemical binding]; other site 192222005152 Q-loop/lid; other site 192222005153 ABC transporter signature motif; other site 192222005154 Walker B; other site 192222005155 D-loop; other site 192222005156 H-loop/switch region; other site 192222005157 HMMPfam hit to PF00005, ABC transporter, score 2e-60 192222005158 PS00211 ABC transporters family signature 192222005159 PS00017 ATP/GTP-binding site motif A (P-loop) 192222005160 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 1.9e-07 192222005161 PS00225 Crystallins beta and gamma 'Greek key' motif signature 192222005162 UDP-glucose-4-epimerase; Region: galE; TIGR01179 192222005163 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 192222005164 NAD binding site [chemical binding]; other site 192222005165 homodimer interface [polypeptide binding]; other site 192222005166 active site 192222005167 substrate binding site [chemical binding]; other site 192222005168 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 2.2e-109 192222005169 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 192222005170 active site 192222005171 catalytic site [active] 192222005172 substrate binding site [chemical binding]; other site 192222005173 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 192222005174 HMMPfam hit to PF03104, DNA polymerase family B,exonuclease do, score 0.0038 192222005175 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 192222005176 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 192222005177 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 192222005178 putative active site [active] 192222005179 HMMPfam hit to PF01075, Glycosyltransferase family,score 3e-20 192222005180 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 192222005181 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 192222005182 putative acyl-acceptor binding pocket; other site 192222005183 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 7e-34 192222005184 1 probable transmembrane helix predicted for Cj1134 by TMHMM2.0 at aa 13-35 192222005185 region with low G+C: 25.4% 192222005186 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 192222005187 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 192222005188 putative metal binding site; other site 192222005189 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 192222005190 Substrate binding site; other site 192222005191 metal-binding site 192222005192 HMMPfam hit to PF00535, Glycosyl transferase, score 4.7e-21 192222005193 HMMPfam hit to PF00535, Glycosyl transferase, score 9.4e-25 192222005194 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 192222005195 active site 192222005196 HMMPfam hit to PF00535, Glycosyl transferase, score 9.9e-28 192222005197 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 192222005198 HMMPfam hit to PF05704, Capsular polysaccharide synthesis protein, score 5.2e-160 192222005199 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 192222005200 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 192222005201 active site 192222005202 HMMPfam hit to PF00535, Glycosyl transferase, score 5.6e-28 192222005203 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 192222005204 active site 192222005205 HMMPfam hit to PF00535, Glycosyl transferase, score 3.7e-39 192222005206 Alpha-2,3-sialyltransferase (CST-I); Region: CST-I; pfam06002 192222005207 HMMPfam hit to PF06002, Alpha-2,3-sialyltransferase (CST-I), score 7.4e-239 192222005208 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 192222005209 NeuB family; Region: NeuB; cl00496 192222005210 SAF domain; Region: SAF; cl00555 192222005211 HMMPfam hit to PF03102, NeuB family, score 9.2e-91 192222005212 HMMPfam hit to PF01354, Antifreeze-like domain,score 1.8e-30 192222005213 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 192222005214 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 192222005215 active site 192222005216 homodimer interface [polypeptide binding]; other site 192222005217 HMMPfam hit to PF02350, UDP-N-acetylglucosamine 2-epimerase, score 5.7e-149 192222005218 Beta-1,4-N-acetylgalactosaminyltransferase (CgtA); Region: CgtA; pfam06306 192222005219 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 192222005220 ligand binding site; other site 192222005221 tetramer interface; other site 192222005222 HMMPfam hit to PF06306,Beta-1,4-N-acetylgalactosaminyltransfera, score 6.3e-101 192222005223 HMMPfam hit to PF02348, Cytidylyltransferase, score 9.4e-24 192222005224 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 192222005225 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 192222005226 active site 192222005227 HMMPfam hit to PF00535, Glycosyl transferase, score 4.8e-39 192222005228 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 192222005229 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 192222005230 putative active site [active] 192222005231 HMMPfam hit to PF01075, Glycosyltransferase family,score 6.3e-22 192222005232 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 192222005233 dimer interface [polypeptide binding]; other site 192222005234 active site 192222005235 HMMPfam hit to PF01380, SIS domain, score 2.5e-19 192222005236 PS00017 ATP/GTP-binding site motif A (P-loop) 192222005237 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 192222005238 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 192222005239 putative ribose interaction site [chemical binding]; other site 192222005240 putative ADP binding site [chemical binding]; other site 192222005241 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 192222005242 active site 192222005243 nucleotide binding site [chemical binding]; other site 192222005244 HIGH motif; other site 192222005245 KMSKS motif; other site 192222005246 HMMPfam hit to PF01467, Cytidylyltransferase, score 4.7e-19 192222005247 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 7.8e-26 192222005248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222005249 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 192222005250 NAD(P) binding site [chemical binding]; other site 192222005251 active site 192222005252 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 1.5e-14 192222005253 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 192222005254 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 192222005255 active site 192222005256 motif I; other site 192222005257 motif II; other site 192222005258 Cytochrome c; Region: Cytochrom_C; cl11414 192222005259 1 probable transmembrane helix predicted for Cj1153 by TMHMM2.0 at aa 4-26 192222005260 HMMPfam hit to PF00034, Cytochrome c, score 5.8e-09 192222005261 PS00190 Cytochrome c family heme-binding site signature 192222005262 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 192222005263 HMMPfam hit to PF03597, Cytochrome oxidase maturation protein cbb3-t, score 4.7e-21 192222005264 1 probable transmembrane helix predicted for Cj1154c by TMHMM2.0 at aa 5-27 192222005265 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 192222005266 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 192222005267 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 192222005268 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 192222005269 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 192222005270 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 2.8e-17 192222005271 PS01229 Hypothetical cof family signature 2 192222005272 HMMPfam hit to PF00122, E1-E2 ATPase, score 1.2e-42 192222005273 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222005274 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 0.031 192222005275 transcription termination factor Rho; Provisional; Region: rho; PRK09376 192222005276 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 192222005277 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 192222005278 RNA binding site [nucleotide binding]; other site 192222005279 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 192222005280 multimer interface [polypeptide binding]; other site 192222005281 Walker A motif; other site 192222005282 ATP binding site [chemical binding]; other site 192222005283 Walker B motif; other site 192222005284 HMMPfam hit to PF07498, Rho termination factor,N-terminal domai, score 4.9e-18 192222005285 HMMPfam hit to PF07497, Rho termination factor,RNA-binding doma, score 2.5e-47 192222005286 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleoti, score 4.3e-68 192222005287 PS00017 ATP/GTP-binding site motif A (P-loop) 192222005288 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08451 192222005289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 192222005290 Walker A motif; other site 192222005291 ATP binding site [chemical binding]; other site 192222005292 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222005293 Walker B motif; other site 192222005294 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 3.1e-07 192222005295 PS00017 ATP/GTP-binding site motif A (P-loop) 192222005296 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 192222005297 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 192222005298 1 probable transmembrane helix predicted for Cj1159c by TMHMM2.0 at aa 7-28 192222005299 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 192222005300 1 probable transmembrane helix predicted for Cj1160c by TMHMM2.0 at aa 13-35 192222005301 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 192222005302 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 192222005303 metal-binding site [ion binding] 192222005304 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 192222005305 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 192222005306 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 2.3e-14 192222005307 PS00154 E1-E2 ATPases phosphorylation site 192222005308 HMMPfam hit to PF00122, E1-E2 ATPase, score 1.5e-61 192222005309 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222005310 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 0.00017 192222005311 Cation efflux family; Region: Cation_efflux; cl00316 192222005312 HMMPfam hit to PF01545, Cation efflux family, score 1.3e-97 192222005313 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 192222005314 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 192222005315 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222005316 Uncharacterized conserved protein [Function unknown]; Region: COG2966 192222005317 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 192222005318 HMMPfam hit to PF06738, Protein of unknown function (DUF1212), score 9.3e-61 192222005319 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 192222005320 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 192222005321 NAD binding site [chemical binding]; other site 192222005322 dimer interface [polypeptide binding]; other site 192222005323 tetramer (dimer of dimers) interface [polypeptide binding]; other site 192222005324 substrate binding site [chemical binding]; other site 192222005325 HMMPfam hit to PF00056, lactate/malate dehydrogenase, NAD binding do, score 2.2e-21 192222005326 HMMPfam hit to PF02866, lactate/malate dehydrogenase, alpha/beta C-t, score 7.5e-40 192222005327 PS00064 L-lactate dehydrogenase active site 192222005328 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 192222005329 HMMPfam hit to PF00597, DedA family, score 7.9e-14 192222005330 PS00225 Crystallins beta and gamma 'Greek key' motif signature 192222005331 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 192222005332 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 192222005333 active site 192222005334 HMMPfam hit to PF00160, Cyclophilin type peptidyl-prolyl cis-tr, score 7.2e-55 192222005335 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature 192222005336 Transcriptional regulator; Region: Transcrip_reg; cl00361 192222005337 HMMPfam hit to PF01709, Domain of unknown function DUF28, score 2.1e-118 192222005338 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 192222005339 4 probable transmembrane helices predicted for Cj1173 by TMHMM2.0 at aa 7-29, 34-53, 62-84 and 89-111 192222005340 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 8.6e-17 192222005341 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 192222005342 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 1.5e-21 192222005343 4 probable transmembrane helices predicted for Cj1174 by TMHMM2.0 at aa 2-20, 30-48, 55-77 and 82-101 192222005344 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 192222005345 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 192222005346 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 192222005347 active site 192222005348 HIGH motif; other site 192222005349 KMSK motif region; other site 192222005350 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 192222005351 tRNA binding surface [nucleotide binding]; other site 192222005352 anticodon binding site; other site 192222005353 HMMPfam hit to PF05746, DALR anticodon binding domain, score 9e-34 192222005354 HMMPfam hit to PF00750, tRNA synthetases class I (R), score 4.9e-73 192222005355 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 192222005356 HMMPfam hit to PF03485, Arginyl tRNA synthetase N terminal do, score 1.6e-26 192222005357 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 192222005358 HMMPfam hit to PF02416, mttA/Hcf106 family, score 3.9e-19 192222005359 1 probable transmembrane helix predicted for Cj1176c by TMHMM2.0 at aa 4-23 192222005360 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 192222005361 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 192222005362 catalytic site [active] 192222005363 G-X2-G-X-G-K; other site 192222005364 HMMPfam hit to PF00625, Guanylate kinase, score 2.1e-36 192222005365 PS00856 Guanylate kinase signature 192222005366 PS00017 ATP/GTP-binding site motif A (P-loop) 192222005367 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 192222005368 HMMPfam hit to PF01311, Bacterial export proteins,family, score 9e-53 192222005369 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 192222005370 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 192222005371 Walker A/P-loop; other site 192222005372 ATP binding site [chemical binding]; other site 192222005373 Q-loop/lid; other site 192222005374 ABC transporter signature motif; other site 192222005375 Walker B; other site 192222005376 D-loop; other site 192222005377 H-loop/switch region; other site 192222005378 HMMPfam hit to PF00005, ABC transporter, score 5.1e-46 192222005379 PS00211 ABC transporters family signature 192222005380 PS00017 ATP/GTP-binding site motif A (P-loop) 192222005381 elongation factor Ts; Provisional; Region: tsf; PRK09377 192222005382 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 192222005383 Elongation factor TS; Region: EF_TS; pfam00889 192222005384 Elongation factor TS; Region: EF_TS; pfam00889 192222005385 HMMPfam hit to PF00889, Elongation factor TS, score 2.1e-78 192222005386 PS01127 Elongation factor Ts signature 2 192222005387 HMMPfam hit to PF00627, UBA/TS-N domain, score 3e-11 192222005388 PS01126 Elongation factor Ts signature 1 192222005389 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 192222005390 rRNA interaction site [nucleotide binding]; other site 192222005391 S8 interaction site; other site 192222005392 putative laminin-1 binding site; other site 192222005393 HMMPfam hit to PF00318, Ribosomal protein S2, score 1.3e-104 192222005394 PS00963 Ribosomal protein S2 signature 2 192222005395 PS00962 Ribosomal protein S2 signature 1 192222005396 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 192222005397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 192222005398 S-adenosylmethionine binding site [chemical binding]; other site 192222005399 HMMPfam hit to PF02353,Cyclopropane-fatty-acyl-phospholipid synthas, score 7.3e-83 192222005400 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 192222005401 Cytochrome c; Region: Cytochrom_C; cl11414 192222005402 HMMPfam hit to PF00034, Cytochrome c, score 0.0076 192222005403 PS00228 Tubulin-beta mRNA autoregulation signal 192222005404 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 192222005405 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 192222005406 intrachain domain interface; other site 192222005407 interchain domain interface [polypeptide binding]; other site 192222005408 heme bH binding site [chemical binding]; other site 192222005409 Qi binding site; other site 192222005410 heme bL binding site [chemical binding]; other site 192222005411 Qo binding site; other site 192222005412 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 192222005413 interchain domain interface [polypeptide binding]; other site 192222005414 intrachain domain interface; other site 192222005415 Qi binding site; other site 192222005416 Qo binding site; other site 192222005417 HMMPfam hit to PF00032, Cytochrome b(C-terminal)/b6/petD, score 2.5e-06 192222005418 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide 192222005419 PS00193 Cytochrome b/b6 Qo site signature 192222005420 HMMPfam hit to PF00033, Cytochrome b(N-terminal)/b6/petB, score 2.9e-61 192222005421 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 192222005422 [2Fe-2S] cluster binding site [ion binding]; other site 192222005423 HMMPfam hit to PF00355, Rieske [2Fe-2S] domain,score 7.4e-08 192222005424 PS00199 Rieske iron-sulfur protein signature 1 192222005425 1 probable transmembrane helix predicted for Cj1186c by TMHMM2.0 at aa 10-29 192222005426 arsenical pump membrane protein; Provisional; Region: PRK15445 192222005427 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 192222005428 transmembrane helices; other site 192222005429 HMMPfam hit to PF02040, Arsenical pump membrane protein, score 7.3e-69 192222005430 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 192222005431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222005432 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 192222005433 HMMPfam hit to PF01134, Glucose inhibited division protein A, score 4e-226 192222005434 PS01280 Glucose inhibited division protein A family signature 1 192222005435 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 192222005436 PAS domain; Region: PAS_9; pfam13426 192222005437 putative active site [active] 192222005438 heme pocket [chemical binding]; other site 192222005439 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 192222005440 dimer interface [polypeptide binding]; other site 192222005441 putative CheW interface [polypeptide binding]; other site 192222005442 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 2.6e-19 192222005443 1 probable transmembrane helix predicted for Cj1190c by TMHMM2.0 at aa 7-41 192222005444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 192222005445 PAS domain; Region: PAS_9; pfam13426 192222005446 putative active site [active] 192222005447 heme pocket [chemical binding]; other site 192222005448 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 192222005449 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 192222005450 8 probable transmembrane helices predicted for Cj1192 by TMHMM2.0 at aa 19-41, 56-78, 91-113, 168-187,210-232, 242-264, 351-373 and 388-407 192222005451 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 3.4e-93 192222005452 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222005453 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 192222005454 Phosphate transporter family; Region: PHO4; cl00396 192222005455 Phosphate transporter family; Region: PHO4; cl00396 192222005456 13 probable transmembrane helices predicted for Cj1194 by TMHMM2.0 at aa 5-27, 32-51, 72-89, 109-128,133-155, 175-197, 276-298, 313-334, 346-368, 388-410,423-445, 449-468 and 480-502 192222005457 HMMPfam hit to PF01384, Phosphate transporter family, score 9.5e-139 192222005458 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 192222005459 dihydroorotase; Provisional; Region: PRK08417 192222005460 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 192222005461 active site 192222005462 HMMPfam hit to PF01979, Amidohydrolase family,score 0.096 192222005463 PS00018 EF-hand calcium-binding domain 192222005464 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 192222005465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222005466 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 192222005467 HMMPfam hit to PF07479, NAD-dependent glycerol-3-phosphate deh, score 6.7e-64 192222005468 HMMPfam hit to PF01210, NAD-dependent glycerol-3-phosphate deh, score 2.4e-14 192222005469 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 192222005470 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 192222005471 GatB domain; Region: GatB_Yqey; cl11497 192222005472 HMMPfam hit to PF02637, GatB/Yqey domain, score 2.1e-54 192222005473 HMMPfam hit to PF01162, PET112 family, C terminal region, score 5e-24 192222005474 HMMPfam hit to PF02934, PET112 family, N terminal region, score 7.9e-155 192222005475 PS01234 PET112 family signature 192222005476 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 192222005477 HMMPfam hit to PF02664, S-Ribosylhomocysteinase (LuxS), score 2.5e-98 192222005478 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 192222005479 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 192222005480 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 192222005481 HMMPfam hit to PF03171, 2OG-Fe(II) oxygenase superfamily, score 1.9e-25 192222005482 NMT1-like family; Region: NMT1_2; cl15260 192222005483 HMMPfam hit to PF03180, NLPA lipoprotein, score 3.8e-131 192222005484 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 192222005485 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 192222005486 THF binding site; other site 192222005487 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 192222005488 substrate binding site [chemical binding]; other site 192222005489 THF binding site; other site 192222005490 zinc-binding site [ion binding]; other site 192222005491 HMMPfam hit to PF01717, Methionine synthase,vitamin-B12 inde, score 6.4e-187 192222005492 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 192222005493 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 192222005494 FAD binding site [chemical binding]; other site 192222005495 HMMPfam hit to PF02219, Methylenetetrahydrofolate reductase, score 3.9e-72 192222005496 ATP synthase A chain; Region: ATP-synt_A; cl00413 192222005497 HMMPfam hit to PF00119, ATP synthase A chain, score 1.5e-29 192222005498 PS00449 ATP synthase a subunit signature 192222005499 DNA repair protein RadA; Provisional; Region: PRK11823 192222005500 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 192222005501 Walker A motif/ATP binding site; other site 192222005502 ATP binding site [chemical binding]; other site 192222005503 Walker B motif; other site 192222005504 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 192222005505 HMMPfam hit to PF03796, DnaB-like helicase C terminal domain, score 0.00015 192222005506 PS00017 ATP/GTP-binding site motif A (P-loop) 192222005507 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 192222005508 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 192222005509 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 192222005510 P loop; other site 192222005511 GTP binding site [chemical binding]; other site 192222005512 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 1.4e-102 192222005513 PS00300 SRP54-type proteins GTP-binding domain signature 192222005514 PS00017 ATP/GTP-binding site motif A (P-loop) 192222005515 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 192222005516 catalytic residues [active] 192222005517 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222005518 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 192222005519 phosphodiesterase; Provisional; Region: PRK12704 192222005520 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 192222005521 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 192222005522 1 probable transmembrane helix predicted for Cj1209 by TMHMM2.0 at aa 5-22 192222005523 HMMPfam hit to PF00013, KH domain, score 3.5e-05 192222005524 HMMPfam hit to PF01966, HD domain, score 7.9e-20 192222005525 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 192222005526 4 probable transmembrane helices predicted for Cj1210 by TMHMM2.0 at aa 13-35, 45-67, 124-146 and 161-180 192222005527 HMMPfam hit to PF00597, DedA family, score 2.4e-05 192222005528 9 probable transmembrane helices predicted for Cj1211 by TMHMM2.0 at aa 15-37, 176-198, 213-235, 242-264,274-294, 307-329, 334-356, 369-391 and 401-418 192222005529 HMMPfam hit to PF03772, Competence protein, score 5.4e-67 192222005530 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222005531 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 192222005532 HMMPfam hit to PF03631, Ribonuclease BN-like family, score 1.1e-66 192222005533 FAD binding domain; Region: FAD_binding_4; pfam01565 192222005534 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 192222005535 HMMPfam hit to PF02913, FAD linked oxidases,C-terminal domain, score 1.4e-99 192222005536 HMMPfam hit to PF01565, FAD binding domain, score 3.5e-71 192222005537 Peptidase family M23; Region: Peptidase_M23; pfam01551 192222005538 HMMPfam hit to PF01551, Peptidase family M23, score 3.6e-53 192222005539 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 192222005540 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 192222005541 HMMPfam hit to PF02578, Uncharacterised ACR, YfiH family COG1496, score 2.3e-21 192222005542 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 192222005543 Lumazine binding domain; Region: Lum_binding; pfam00677 192222005544 Lumazine binding domain; Region: Lum_binding; pfam00677 192222005545 HMMPfam hit to PF00677, Lumazine binding domain,score 2.3e-25 192222005546 1 probable transmembrane helix predicted for Cj1219c by TMHMM2.0 at aa 5-27 192222005547 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 192222005548 oligomerisation interface [polypeptide binding]; other site 192222005549 mobile loop; other site 192222005550 roof hairpin; other site 192222005551 HMMPfam hit to PF00166, Chaperonin 10 Kd subunit,score 5.4e-35 192222005552 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 192222005553 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 192222005554 ring oligomerisation interface [polypeptide binding]; other site 192222005555 ATP/Mg binding site [chemical binding]; other site 192222005556 stacking interactions; other site 192222005557 hinge regions; other site 192222005558 HMMPfam hit to PF00118, TCP-1/cpn60 chaperonin family, score 5.5e-196 192222005559 PS00296 Chaperonins cpn60 signature 192222005560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 192222005561 dimer interface [polypeptide binding]; other site 192222005562 phosphorylation site [posttranslational modification] 192222005563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 192222005564 ATP binding site [chemical binding]; other site 192222005565 Mg2+ binding site [ion binding]; other site 192222005566 G-X-G motif; other site 192222005567 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 6e-20 192222005568 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 9.6e-05 192222005569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 192222005570 active site 192222005571 phosphorylation site [posttranslational modification] 192222005572 intermolecular recognition site; other site 192222005573 dimerization interface [polypeptide binding]; other site 192222005574 Helix-turn-helix domains; Region: HTH; cl00088 192222005575 DNA binding site [nucleotide binding] 192222005576 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 2.7e-18 192222005577 HMMPfam hit to PF00072, Response regulator receiver domain, score 3e-25 192222005578 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 192222005579 octamerization interface [polypeptide binding]; other site 192222005580 diferric-oxygen binding site [ion binding]; other site 192222005581 HMMPfam hit to PF01814, Hemerythrin HHE cation binding domain, score 1.1e-05 192222005582 HMMPfam hit to PF01814, Hemerythrin HHE cation binding domain, score 0.00038 192222005583 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 192222005584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 192222005585 dimer interface [polypeptide binding]; other site 192222005586 phosphorylation site [posttranslational modification] 192222005587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 192222005588 ATP binding site [chemical binding]; other site 192222005589 Mg2+ binding site [ion binding]; other site 192222005590 G-X-G motif; other site 192222005591 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 3.2e-07 192222005592 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 3.7e-05 192222005593 HMMPfam hit to PF00672, HAMP domain, score 7.2e-08 192222005594 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 192222005595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 192222005596 active site 192222005597 phosphorylation site [posttranslational modification] 192222005598 intermolecular recognition site; other site 192222005599 dimerization interface [polypeptide binding]; other site 192222005600 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 192222005601 DNA binding site [nucleotide binding] 192222005602 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 6.9e-19 192222005603 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.9e-31 192222005604 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 192222005605 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 192222005606 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 192222005607 protein binding site [polypeptide binding]; other site 192222005608 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 192222005609 protein binding site [polypeptide binding]; other site 192222005610 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 0.03 192222005611 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 1.7e-08 192222005612 HMMPfam hit to PF00089, Trypsin, score 1.2e-20 192222005613 chaperone protein DnaJ; Provisional; Region: PRK14299 192222005614 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 192222005615 HSP70 interaction site [polypeptide binding]; other site 192222005616 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 192222005617 substrate binding site [polypeptide binding]; other site 192222005618 dimer interface [polypeptide binding]; other site 192222005619 HMMPfam hit to PF00226, DnaJ domain, score 1.2e-40 192222005620 PS00636 Nt-dnaJ domain signature 192222005621 HMMPfam hit to PF01556, DnaJ C terminal region,score 6.2e-22 192222005622 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 192222005623 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 192222005624 DNA binding residues [nucleotide binding] 192222005625 putative dimer interface [polypeptide binding]; other site 192222005626 HMMPfam hit to PF00376, MerR family regulatory protein, score 1.4e-07 192222005627 PS00552 Bacterial regulatory proteins, merR family signature 192222005628 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 192222005629 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 192222005630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222005631 13 probable transmembrane helices predicted for Cj1231 by TMHMM2.0 at aa 4-22, 29-48, 52-71, 83-105,115-133, 146-168, 178-200, 207-229, 233-250, 262-281,291-313, 320-342 and 352-374 192222005632 HMMPfam hit to PF02254, TrkA-N domain, score 5.9e-08 192222005633 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 192222005634 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 192222005635 motif II; other site 192222005636 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 4.5e-18 192222005637 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 192222005638 HMMPfam hit to PF02092, Glycyl-tRNA synthetase beta subunit, score 6.5e-195 192222005639 Peptidase family M23; Region: Peptidase_M23; pfam01551 192222005640 HMMPfam hit to PF01551, Peptidase family M23, score 6.7e-45 192222005641 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 192222005642 HMMPfam hit to PF02636, Uncharacterized ACR,COG1565, score 2.2e-05 192222005643 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 192222005644 HMMPfam hit to PF02541, Ppx/GppA phosphatase family, score 1.7e-06 192222005645 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 192222005646 active site 192222005647 hydrophilic channel; other site 192222005648 dimerization interface [polypeptide binding]; other site 192222005649 catalytic residues [active] 192222005650 active site lid [active] 192222005651 HMMPfam hit to PF03740, Pyridoxal phosphate biosynthesis protein Pdx, score 7.6e-178 192222005652 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 192222005653 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 192222005654 HMMPfam hit to PF04166, Pyridoxal phosphate biosynthetic protein Pdx, score 1.4e-135 192222005655 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 192222005656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 192222005657 putative substrate translocation pore; other site 192222005658 12 probable transmembrane helices predicted for Cj1241 by TMHMM2.0 at aa 7-29, 44-66, 73-90, 100-122,129-151, 156-178, 203-225, 240-259, 268-290, 295-317,338-360 and 364-381 192222005659 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.7e-39 192222005660 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 192222005661 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 192222005662 substrate binding site [chemical binding]; other site 192222005663 active site 192222005664 HMMPfam hit to PF01208, Uroporphyrinogen decarboxylase (URO-D), score 2.1e-132 192222005665 PS00906 Uroporphyrinogen decarboxylase signature 1 192222005666 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 192222005667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 192222005668 FeS/SAM binding site; other site 192222005669 HMMPfam hit to PF04055, Radical SAM superfamily,score 4.1e-16 192222005670 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 192222005671 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 192222005672 GIY-YIG motif/motif A; other site 192222005673 active site 192222005674 catalytic site [active] 192222005675 putative DNA binding site [nucleotide binding]; other site 192222005676 metal binding site [ion binding]; metal-binding site 192222005677 UvrB/uvrC motif; Region: UVR; pfam02151 192222005678 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 192222005679 HMMPfam hit to PF02151, UvrB/uvrC motif, score 2.9e-08 192222005680 HMMPfam hit to PF01541, GIY-YIG catalytic domain,score 1.4e-29 192222005681 GMP synthase; Reviewed; Region: guaA; PRK00074 192222005682 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 192222005683 AMP/PPi binding site [chemical binding]; other site 192222005684 candidate oxyanion hole; other site 192222005685 catalytic triad [active] 192222005686 potential glutamine specificity residues [chemical binding]; other site 192222005687 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 192222005688 ATP Binding subdomain [chemical binding]; other site 192222005689 Ligand Binding sites [chemical binding]; other site 192222005690 Dimerization subdomain; other site 192222005691 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 1.7e-57 192222005692 PS00442 Glutamine amidotransferases class-I active site 192222005693 HMMPfam hit to PF00958, GMP synthase C terminal domain, score 1e-65 192222005694 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 192222005695 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 192222005696 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 192222005697 ATP-grasp domain; Region: ATP-grasp_4; cl03087 192222005698 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 192222005699 HMMPfam hit to PF02844, Phosphoribosylglycinamide synthetase, N doma, score 1.3e-23 192222005700 HMMPfam hit to PF02842, Phosphoribosylglycinamide synthetase, B doma, score 8.3e-40 192222005701 HMMPfam hit to PF01071, Phosphoribosylglycinamide synthetase, ATP-gr, score 5.4e-67 192222005702 HMMPfam hit to PF02843, Phosphoribosylglycinamide synthetase, C doma, score 4.1e-34 192222005703 RDD family; Region: RDD; cl00746 192222005704 HMMPfam hit to PF06271, RDD family, score 5.3e-39 192222005705 2 probable transmembrane helices predicted for Cj1251 by TMHMM2.0 at aa 23-42 and 62-84 192222005706 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 192222005707 OstA-like protein; Region: OstA; cl00844 192222005708 Organic solvent tolerance protein; Region: OstA_C; pfam04453 192222005709 HMMPfam hit to PF04453, Organic solvent tolerance protein, score 6.9e-85 192222005710 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 192222005711 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 192222005712 oligomer interface [polypeptide binding]; other site 192222005713 RNA binding site [nucleotide binding]; other site 192222005714 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 192222005715 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 192222005716 RNase E interface [polypeptide binding]; other site 192222005717 trimer interface [polypeptide binding]; other site 192222005718 active site 192222005719 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 192222005720 putative nucleic acid binding region [nucleotide binding]; other site 192222005721 G-X-X-G motif; other site 192222005722 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 192222005723 RNA binding site [nucleotide binding]; other site 192222005724 HMMPfam hit to PF01138, 3' exoribonuclease family,domain, score 3.8e-27 192222005725 HMMPfam hit to PF03725, 3' exoribonuclease family,domain, score 1.7e-07 192222005726 HMMPfam hit to PF03726, Polyribonucleotide nucleotidyltransferase,, score 3.1e-25 192222005727 HMMPfam hit to PF01138, 3' exoribonuclease family,domain, score 4.7e-47 192222005728 HMMPfam hit to PF03725, 3' exoribonuclease family,domain, score 6.1e-20 192222005729 HMMPfam hit to PF00013, KH domain, score 1.6e-13 192222005730 HMMPfam hit to PF00575, S1 RNA binding domain,score 5.7e-06 192222005731 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 192222005732 putative active site [active] 192222005733 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 192222005734 active site 1 [active] 192222005735 dimer interface [polypeptide binding]; other site 192222005736 hexamer interface [polypeptide binding]; other site 192222005737 active site 2 [active] 192222005738 HMMPfam hit to PF01361, Tautomerase enzyme, score 3.6e-27 192222005739 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 192222005740 1 probable transmembrane helix predicted for Cj1256c by TMHMM2.0 at aa 4-21 192222005741 drug efflux system protein MdtG; Provisional; Region: PRK09874 192222005742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 192222005743 putative substrate translocation pore; other site 192222005744 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 9.6e-44 192222005745 Low molecular weight phosphatase family; Region: LMWPc; cd00115 192222005746 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 192222005747 active site 192222005748 HMMPfam hit to PF01451, Low molecular weight phosphotyrosine protein, score 1.8e-28 192222005749 Campylobacter major outer membrane protein; Region: Campylo_MOMP; pfam05538 192222005750 HMMPfam hit to PF05538, Campylobacter major outer membrane prote, score 0 192222005751 chaperone protein DnaJ; Provisional; Region: PRK10767 192222005752 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 192222005753 HSP70 interaction site [polypeptide binding]; other site 192222005754 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 192222005755 substrate binding site [polypeptide binding]; other site 192222005756 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 192222005757 Zn binding sites [ion binding]; other site 192222005758 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 192222005759 dimer interface [polypeptide binding]; other site 192222005760 HMMPfam hit to PF01556, DnaJ C terminal region,score 2e-59 192222005761 HMMPfam hit to PF00684, DnaJ central domain (4 repeats), score 1.2e-22 192222005762 PS00637 CXXCXGXG dnaJ domain signature 192222005763 HMMPfam hit to PF00226, DnaJ domain, score 1.4e-39 192222005764 PS00636 Nt-dnaJ domain signature 192222005765 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 192222005766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 192222005767 active site 192222005768 phosphorylation site [posttranslational modification] 192222005769 intermolecular recognition site; other site 192222005770 dimerization interface [polypeptide binding]; other site 192222005771 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 192222005772 DNA binding site [nucleotide binding] 192222005773 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.5e-28 192222005774 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.7e-18 192222005775 adaptive-response sensory kinase; Validated; Region: PRK09303 192222005776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 192222005777 dimer interface [polypeptide binding]; other site 192222005778 phosphorylation site [posttranslational modification] 192222005779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 192222005780 ATP binding site [chemical binding]; other site 192222005781 Mg2+ binding site [ion binding]; other site 192222005782 G-X-G motif; other site 192222005783 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature 192222005784 2 probable transmembrane helices predicted for Cj1262 by TMHMM2.0 at aa 11-30 and 132-154 192222005785 HMMPfam hit to PF00672, HAMP domain, score 9.5e-06 192222005786 PS00146 Beta-lactamase class-A active site 192222005787 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2.9e-05 192222005788 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 3.8e-07 192222005789 recombination protein RecR; Reviewed; Region: recR; PRK00076 192222005790 RecR protein; Region: RecR; pfam02132 192222005791 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 192222005792 putative active site [active] 192222005793 putative metal-binding site [ion binding]; other site 192222005794 tetramer interface [polypeptide binding]; other site 192222005795 HMMPfam hit to PF02132, RecR protein, score 1.8e-13 192222005796 PS01300 RecR protein signature 192222005797 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 192222005798 putative substrate-binding site; other site 192222005799 nickel binding site [ion binding]; other site 192222005800 HMMPfam hit to PF01750, Hydrogenase maturation protease, score 2.7e-22 192222005801 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 192222005802 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 192222005803 HMMPfam hit to PF01292, Cytochrome b561 family,score 2.6e-37 192222005804 PS00883 Nickel-dependent hydrogenases b-type cytochrome subunit signature 2 192222005805 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222005806 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 192222005807 HMMPfam hit to PF00374, Nickel-dependent hydrogenase, score 5.7e-256 192222005808 PS00508 Nickel-dependent hydrogenases large subunit signature 2 192222005809 PS00507 Nickel-dependent hydrogenases large subunit signature 1 192222005810 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 192222005811 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 192222005812 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 Kd sub, score 7.5e-05 192222005813 PS00024 Hemopexin domain signature 192222005814 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 192222005815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 192222005816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222005817 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 2e-31 192222005818 HMMPfam hit to PF05430, Protein of unknown function (DUF752), score 4.9e-111 192222005819 AMIN domain; Region: AMIN; pfam11741 192222005820 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 192222005821 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 192222005822 active site 192222005823 metal binding site [ion binding]; metal-binding site 192222005824 HMMPfam hit to PF01520, N-acetylmuramoyl-L-alanine amidase, score 2.7e-47 192222005825 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 192222005826 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 192222005827 FMN binding site [chemical binding]; other site 192222005828 substrate binding site [chemical binding]; other site 192222005829 putative catalytic residue [active] 192222005830 HMMPfam hit to PF03060, 2-nitropropane dioxygenase,score 5.8e-95 192222005831 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 192222005832 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 192222005833 active site 192222005834 HIGH motif; other site 192222005835 dimer interface [polypeptide binding]; other site 192222005836 KMSKS motif; other site 192222005837 HMMPfam hit to PF01479, S4 domain, score 0.0012 192222005838 HMMPfam hit to PF00579, tRNA synthetases class I (W and Y), score 8.6e-97 192222005839 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 192222005840 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 192222005841 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 192222005842 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 192222005843 synthetase active site [active] 192222005844 NTP binding site [chemical binding]; other site 192222005845 metal binding site [ion binding]; metal-binding site 192222005846 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 192222005847 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 192222005848 HMMPfam hit to PF01842, ACT domain, score 1.3e-06 192222005849 HMMPfam hit to PF02824, TGS domain, score 6.4e-20 192222005850 HMMPfam hit to PF04607, Region found in RelA / SpoT proteins, score 2.4e-45 192222005851 HMMPfam hit to PF01966, HD domain, score 8.1e-07 192222005852 PS00190 Cytochrome c family heme-binding site signature 192222005853 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 192222005854 HMMPfam hit to PF01192, RNA polymerase Rpb6, score 2.8e-19 192222005855 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 192222005856 putative nucleotide binding site [chemical binding]; other site 192222005857 uridine monophosphate binding site [chemical binding]; other site 192222005858 homohexameric interface [polypeptide binding]; other site 192222005859 HMMPfam hit to PF00696, Amino acid kinase family,score 7.1e-54 192222005860 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 192222005861 Peptidase family M23; Region: Peptidase_M23; pfam01551 192222005862 HMMPfam hit to PF01551, Peptidase family M23, score 1e-18 192222005863 1 probable transmembrane helix predicted for Cj1275c by TMHMM2.0 at aa 5-24 192222005864 FtsX-like permease family; Region: FtsX; cl15850 192222005865 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 192222005866 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 192222005867 Walker A/P-loop; other site 192222005868 ATP binding site [chemical binding]; other site 192222005869 Q-loop/lid; other site 192222005870 ABC transporter signature motif; other site 192222005871 Walker B; other site 192222005872 D-loop; other site 192222005873 H-loop/switch region; other site 192222005874 HMMPfam hit to PF00005, ABC transporter, score 2.7e-54 192222005875 PS00211 ABC transporters family signature 192222005876 PS00017 ATP/GTP-binding site motif A (P-loop) 192222005877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 192222005878 HMMPfam hit to PF02390, methyltransferase,score 6.1e-37 192222005879 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 192222005880 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 192222005881 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 192222005882 HMMPfam hit to PF00041, Fibronectin type III domain, score 0.0033 192222005883 HMMPfam hit to PF00041, Fibronectin type III domain, score 0.0079 192222005884 HMMPfam hit to PF00041, Fibronectin type III domain, score 0.0037 192222005885 HMMPfam hit to PF00041, Fibronectin type III domain, score 0.0015 192222005886 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222005887 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 192222005888 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 192222005889 RNA binding surface [nucleotide binding]; other site 192222005890 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 192222005891 active site 192222005892 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 4e-45 192222005893 PS01129 Rlu family of pseudouridine synthase signature 192222005894 HMMPfam hit to PF01479, S4 domain, score 4.3e-11 192222005895 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 192222005896 HMMPfam hit to PF01098, Cell cycle protein, score 1.9e-95 192222005897 9 probable transmembrane helices predicted for Cj1282 by TMHMM2.0 at aa 15-37, 44-61, 65-87, 138-153,158-177, 182-201, 265-287, 300-322 and 332-354 192222005898 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 192222005899 Cation transport protein; Region: TrkH; cl10514 192222005900 11 probable transmembrane helices predicted for Cj1283 by TMHMM2.0 at aa 13-32, 42-59, 72-94, 127-149,156-175, 190-212, 225-247, 290-324, 345-367, 382-404 and 409-430 192222005901 HMMPfam hit to PF02386, Cation transport protein,score 7.5e-81 192222005902 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 192222005903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222005904 HMMPfam hit to PF02254, TrkA-N domain, score 1.4e-30 192222005905 HMMPfam hit to PF02080, TrkA-C domain, score 3.7e-05 192222005906 NMT1-like family; Region: NMT1_2; cl15260 192222005907 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 192222005908 HMMPfam hit to PF02621, Uncharacterized ACR,COG1427, score 3.5e-26 192222005909 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 192222005910 active site 192222005911 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 6e-05 192222005912 Malic enzyme, N-terminal domain; Region: malic; pfam00390 192222005913 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 192222005914 putative NAD(P) binding site [chemical binding]; other site 192222005915 HMMPfam hit to PF03949, Malic enzyme, NAD binding domain, score 4.5e-126 192222005916 HMMPfam hit to PF00390, Malic enzyme, N-terminal domain, score 1.6e-74 192222005917 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 192222005918 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 192222005919 active site 192222005920 HIGH motif; other site 192222005921 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 192222005922 active site 192222005923 KMSKS motif; other site 192222005924 HMMPfam hit to PF00749, tRNA synthetases class I (E and Q), cata, score 7.3e-141 192222005925 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 192222005926 SurA N-terminal domain; Region: SurA_N_3; cl07813 192222005927 PPIC-type PPIASE domain; Region: Rotamase; cl08278 192222005928 1 probable transmembrane helix predicted for Cj1289 by TMHMM2.0 at aa 5-27 192222005929 biotin carboxylase; Validated; Region: PRK08462 192222005930 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 192222005931 ATP-grasp domain; Region: ATP-grasp_4; cl03087 192222005932 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 192222005933 HMMPfam hit to PF02785, Biotin carboxylase C-terminal domain, score 2.5e-57 192222005934 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 3.4e-108 192222005935 PS00867 Carbamoyl-phosphate synthase subdomain signature 2 192222005936 PS00866 Carbamoyl-phosphate synthase subdomain signature 1 192222005937 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 1.6e-46 192222005938 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 192222005939 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 192222005940 carboxyltransferase (CT) interaction site; other site 192222005941 biotinylation site [posttranslational modification]; other site 192222005942 HMMPfam hit to PF00364, Biotin-requiring enzyme,score 9e-27 192222005943 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature 192222005944 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 192222005945 trimer interface [polypeptide binding]; other site 192222005946 active site 192222005947 HMMPfam hit to PF00692, dUTPase, score 0.00019 192222005948 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 192222005949 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 192222005950 NAD(P) binding site [chemical binding]; other site 192222005951 homodimer interface [polypeptide binding]; other site 192222005952 substrate binding site [chemical binding]; other site 192222005953 active site 192222005954 HMMPfam hit to PF02719, Polysaccharide biosynthesis protein, score 7e-09 192222005955 PS00017 ATP/GTP-binding site motif A (P-loop) 192222005956 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 192222005957 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 192222005958 inhibitor-cofactor binding pocket; inhibition site 192222005959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222005960 catalytic residue [active] 192222005961 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 4.6e-110 192222005962 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 192222005963 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 192222005964 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 192222005965 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 192222005966 Phosphopantetheine attachment site; Region: PP-binding; cl09936 192222005967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 192222005968 S-adenosylmethionine binding site [chemical binding]; other site 192222005969 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 192222005970 dimer interface [polypeptide binding]; other site 192222005971 substrate binding site [chemical binding]; other site 192222005972 metal binding site [ion binding]; metal-binding site 192222005973 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222005974 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 192222005975 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 192222005976 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222005977 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12880 192222005978 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 192222005979 dimer interface [polypeptide binding]; other site 192222005980 active site 192222005981 CoA binding pocket [chemical binding]; other site 192222005982 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 192222005983 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 192222005984 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 192222005985 AMP-binding enzyme; Region: AMP-binding; cl15778 192222005986 HMMPfam hit to PF00501, AMP-binding enzyme, score 1.4e-85 192222005987 PS00455 AMP-binding domain signature 192222005988 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 192222005989 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 192222005990 ligand binding site; other site 192222005991 tetramer interface; other site 192222005992 HMMPfam hit to PF02348, Cytidylyltransferase, score 2e-25 192222005993 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 192222005994 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 192222005995 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 192222005996 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.3e-10 192222005997 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 192222005998 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 192222005999 substrate binding site [chemical binding]; other site 192222006000 glutamase interaction surface [polypeptide binding]; other site 192222006001 HMMPfam hit to PF00977, Histidine biosynthesis protein, score 1.2e-71 192222006002 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 192222006003 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 192222006004 putative active site [active] 192222006005 oxyanion strand; other site 192222006006 catalytic triad [active] 192222006007 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 1.6e-38 192222006008 HMMPfam hit to PF01174, SNO glutamine amidotransferase family, score 0.0029 192222006009 PS00442 Glutamine amidotransferases class-I active site 192222006010 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 192222006011 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 192222006012 Ligand Binding Site [chemical binding]; other site 192222006013 PS00294 Prenyl group binding site (CAAX box) 192222006014 PS00761 Signal peptidases I signature 3 192222006015 pseudaminic acid synthase; Region: PseI; TIGR03586 192222006016 NeuB family; Region: NeuB; cl00496 192222006017 SAF domain; Region: SAF; cl00555 192222006018 HMMPfam hit to PF03102, NeuB family, score 2.3e-103 192222006019 HMMPfam hit to PF01354, Antifreeze-like domain,score 5.4e-28 192222006020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 192222006021 HMMPfam hit to PF01973, Protein of unknown function DUF115, score 4.6e-79 192222006022 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 192222006023 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 192222006024 NAD binding site [chemical binding]; other site 192222006025 substrate binding site [chemical binding]; other site 192222006026 active site 192222006027 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 5e-63 192222006028 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 192222006029 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 192222006030 inhibitor-cofactor binding pocket; inhibition site 192222006031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222006032 catalytic residue [active] 192222006033 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 1.3e-71 192222006034 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 192222006035 putative trimer interface [polypeptide binding]; other site 192222006036 putative CoA binding site [chemical binding]; other site 192222006037 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.66 192222006038 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 7.8 192222006039 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 31 192222006040 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 192222006041 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 192222006042 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 192222006043 Ligand Binding Site [chemical binding]; other site 192222006044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 192222006045 S-adenosylmethionine binding site [chemical binding]; other site 192222006046 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 192222006047 NeuB family; Region: NeuB; cl00496 192222006048 SAF domain; Region: SAF; cl00555 192222006049 HMMPfam hit to PF03102, NeuB family, score 1.8e-121 192222006050 PS00141 Eukaryotic and viral aspartyl proteases active site 192222006051 PS00867 Carbamoyl-phosphate synthase subdomain signature 2 192222006052 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222006053 HMMPfam hit to PF01354, Antifreeze-like domain,score 3.8e-15 192222006054 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 192222006055 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 192222006056 active site 192222006057 homodimer interface [polypeptide binding]; other site 192222006058 HMMPfam hit to PF02350, UDP-N-acetylglucosamine 2-epimerase, score 2.9e-153 192222006059 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 192222006060 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 192222006061 Substrate binding site; other site 192222006062 metal-binding site 192222006063 HMMPfam hit to PF00571, CBS domain, score 0.0046 192222006064 HMMPfam hit to PF00571, CBS domain, score 8.5e-07 192222006065 HMMPfam hit to PF00483, Nucleotidyl transferase,score 4.2e-30 192222006066 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 192222006067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222006068 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 192222006069 ligand binding site; other site 192222006070 tetramer interface; other site 192222006071 HMMPfam hit to PF02348, Cytidylyltransferase, score 6.7e-53 192222006072 flagellin modification protein A; Provisional; Region: PRK09186 192222006073 classical (c) SDR, subgroup 8; Region: SDR_c8; cd08930 192222006074 putative NAD(P) binding site [chemical binding]; other site 192222006075 active site 192222006076 HMMPfam hit to PF00106, short chain dehydrogenase,score 2.9e-15 192222006077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 192222006078 HMMPfam hit to PF01973, Protein of unknown function DUF115, score 4.1e-85 192222006079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 192222006080 HMMPfam hit to PF01973, Protein of unknown function DUF115, score 3.1e-83 192222006081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 192222006082 HMMPfam hit to PF01973, Protein of unknown function DUF115, score 4.6e-79 192222006083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 192222006084 HMMPfam hit to PF01973, Protein of unknown function DUF115, score 9.6e-90 192222006085 flagellin; Provisional; Region: PRK13589 192222006086 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 192222006087 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 192222006088 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 192222006089 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 192222006090 HMMPfam hit to PF00700, Bacterial flagellin C-terminus, score 6.3e-36 192222006091 HMMPfam hit to PF07196, Flagellin hook IN motif,score 2.2e-10 192222006092 HMMPfam hit to PF07196, Flagellin hook IN motif,score 5.4e-08 192222006093 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 6.6e-69 192222006094 flagellin; Reviewed; Region: PRK08411 192222006095 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 192222006096 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 192222006097 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 192222006098 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 192222006099 HMMPfam hit to PF00700, Bacterial flagellin C-terminus, score 1.5e-36 192222006100 HMMPfam hit to PF07196, Flagellin hook IN motif,score 2.2e-11 192222006101 HMMPfam hit to PF07196, Flagellin hook IN motif,score 3.2e-09 192222006102 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 7.1e-69 192222006103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 192222006104 HMMPfam hit to PF01973, Protein of unknown function DUF115, score 8.8e-71 192222006105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 192222006106 HMMPfam hit to PF01973, Protein of unknown function DUF115, score 9.8e-73 192222006107 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 192222006108 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 1.5e-06 192222006109 1 probable transmembrane helix predicted for Cj1343c by TMHMM2.0 at aa 7-26 192222006110 UGMP family protein; Validated; Region: PRK09604 192222006111 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 192222006112 HMMPfam hit to PF00814, Glycoprotease family, score 2.3e-19 192222006113 PS01016 Glycoprotease family signature 192222006114 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 192222006115 active site 192222006116 Zn binding site [ion binding]; other site 192222006117 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 192222006118 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 192222006119 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 192222006120 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 192222006121 HMMPfam hit to PF02670, 1-deoxy-D-xylulose 5-phosphate reduct, score 5.7e-116 192222006122 PS00430 TonB-dependent receptor proteins signature 1 192222006123 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 192222006124 HMMPfam hit to PF01148, Cytidylyltransferase family, score 7.5e-79 192222006125 PS01315 Phosphatidate cytidylyltransferase signature 192222006126 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222006127 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 192222006128 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 192222006129 Domain of unknown function (DUF814); Region: DUF814; pfam05670 192222006130 HMMPfam hit to PF05670, Domain of unknown function (DUF814), score 1.5e-35 192222006131 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 192222006132 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 192222006133 GTP binding site; other site 192222006134 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 192222006135 dimerization interface [polypeptide binding]; other site 192222006136 substrate binding site [chemical binding]; other site 192222006137 active site 192222006138 calcium binding site [ion binding]; other site 192222006139 HMMPfam hit to PF02253, Phospholipase A1, score 4.1e-135 192222006140 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 192222006141 ABC-ATPase subunit interface; other site 192222006142 dimer interface [polypeptide binding]; other site 192222006143 putative PBP binding regions; other site 192222006144 9 probable transmembrane helices predicted for Cj1352 by TMHMM2.0 at aa 11-33, 54-76, 96-125, 138-160,180-202, 214-236, 241-263, 270-292 and 297-316 192222006145 HMMPfam hit to PF01032, FecCD transport family,score 1.7e-49 192222006146 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 192222006147 ABC-ATPase subunit interface; other site 192222006148 dimer interface [polypeptide binding]; other site 192222006149 putative PBP binding regions; other site 192222006150 9 probable transmembrane helices predicted for Cj1353 by TMHMM2.0 at aa 5-27, 37-59, 64-86, 101-120,125-147, 170-192, 222-244, 259-281 and 288-307 192222006151 HMMPfam hit to PF01032, FecCD transport family,score 3.3e-17 192222006152 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 192222006153 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 192222006154 Walker A/P-loop; other site 192222006155 ATP binding site [chemical binding]; other site 192222006156 Q-loop/lid; other site 192222006157 ABC transporter signature motif; other site 192222006158 Walker B; other site 192222006159 D-loop; other site 192222006160 H-loop/switch region; other site 192222006161 HMMPfam hit to PF00005, ABC transporter, score 9.3e-49 192222006162 PS00017 ATP/GTP-binding site motif A (P-loop) 192222006163 PS00211 ABC transporters family signature 192222006164 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 192222006165 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 192222006166 putative ligand binding residues [chemical binding]; other site 192222006167 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222006168 HMMPfam hit to PF01497, Periplasmic binding protein, score 1.2e-72 192222006169 Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit [Inorganic ion transport and metabolism]; Region: NrfA; COG3303 192222006170 HMMPfam hit to PF02335, Cytochrome c552, score 1.9e-15 192222006171 PS00190 Cytochrome c family heme-binding site signature 192222006172 PS00190 Cytochrome c family heme-binding site signature 192222006173 PS00190 Cytochrome c family heme-binding site signature 192222006174 PS00190 Cytochrome c family heme-binding site signature 192222006175 PS00190 Cytochrome c family heme-binding site signature 192222006176 1 probable transmembrane helix predicted for Cj1357c by TMHMM2.0 at aa 5-22 192222006177 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 192222006178 HMMPfam hit to PF03264, NapC/NirT cytochrome c family, N-termin, score 8.9e-12 192222006179 PS00190 Cytochrome c family heme-binding site signature 192222006180 PS00190 Cytochrome c family heme-binding site signature 192222006181 PS00190 Cytochrome c family heme-binding site signature 192222006182 1 probable transmembrane helix predicted for Cj1358c by TMHMM2.0 at aa 13-35 192222006183 polyphosphate kinase; Provisional; Region: PRK05443 192222006184 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 192222006185 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 192222006186 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 192222006187 putative domain interface [polypeptide binding]; other site 192222006188 putative active site [active] 192222006189 catalytic site [active] 192222006190 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 192222006191 putative domain interface [polypeptide binding]; other site 192222006192 putative active site [active] 192222006193 catalytic site [active] 192222006194 HMMPfam hit to PF02503, Polyphosphate kinase, score 0 192222006195 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 192222006196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 192222006197 Walker A motif; other site 192222006198 ATP binding site [chemical binding]; other site 192222006199 Walker B motif; other site 192222006200 arginine finger; other site 192222006201 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 192222006202 HMMPfam hit to PF05496, Holliday junction DNA helicase ruvB N-termin, score 1.3e-26 192222006203 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 5.5e-28 192222006204 PS00017 ATP/GTP-binding site motif A (P-loop) 192222006205 HMMPfam hit to PF05491, Holliday junction DNA helicase ruvB C-termin, score 4.6e-39 192222006206 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 192222006207 HMMPfam hit to PF01594, Domain of unknown function DUF20, score 3.5e-68 192222006208 7 probable transmembrane helices predicted for Cj1363 by TMHMM2.0 at aa 7-41, 56-78, 157-179, 194-216,225-247, 262-284 and 305-327 192222006209 fumarate hydratase; Reviewed; Region: fumC; PRK00485 192222006210 Class II fumarases; Region: Fumarase_classII; cd01362 192222006211 active site 192222006212 tetramer interface [polypeptide binding]; other site 192222006213 HMMPfam hit to PF00206, Lyase, score 3.2e-163 192222006214 PS00163 Fumarate lyases signature 192222006215 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 192222006216 catalytic triad [active] 192222006217 putative active site [active] 192222006218 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 192222006219 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 192222006220 HMMPfam hit to PF03797, Autotransporter beta-domain, score 3.7e-37 192222006221 HMMPfam hit to PF00082, Subtilase family, score 6.3e-11 192222006222 PS00138 Serine proteases, subtilase family, serine active site 192222006223 PS00137 Serine proteases, subtilase family,histidine active site 192222006224 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 192222006225 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 192222006226 glutaminase active site [active] 192222006227 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 192222006228 dimer interface [polypeptide binding]; other site 192222006229 active site 192222006230 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 192222006231 dimer interface [polypeptide binding]; other site 192222006232 active site 192222006233 HMMPfam hit to PF01380, SIS domain, score 0.00048 192222006234 HMMPfam hit to PF01380, SIS domain, score 3e-39 192222006235 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 9.2e-23 192222006236 PS00443 Glutamine amidotransferases class-II active site 192222006237 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 192222006238 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 192222006239 hypothetical protein; Provisional; Region: PRK08444 192222006240 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 192222006241 FeS/SAM binding site; other site 192222006242 HMMPfam hit to PF04055, Radical SAM superfamily,score 2.2e-16 192222006243 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 192222006244 Sulfate transporter family; Region: Sulfate_transp; cl15842 192222006245 HMMPfam hit to PF00860, Permease family, score 4e-21 192222006246 13 probable transmembrane helices predicted for Cj1369 by TMHMM2.0 at aa 17-39, 44-66, 73-95, 100-122,131-153, 168-186, 191-208, 246-268, 289-311, 321-343,350-367, 377-408 and 420-438 192222006247 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 192222006248 active site 192222006249 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 1.2e-06 192222006250 PS00103 Purine/pyrimidine phosphoribosyl transferases signature 192222006251 VacJ like lipoprotein; Region: VacJ; cl01073 192222006252 HMMPfam hit to PF04333, VacJ like lipoprotein,score 1.9e-116 192222006253 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 192222006254 HMMPfam hit to PF05494, Toluene tolerance, Ttg2,score 3.8e-69 192222006255 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 192222006256 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 192222006257 13 probable transmembrane helices predicted for Cj1373 by TMHMM2.0 at aa 15-32, 228-245, 249-268, 273-295,299-321, 353-375, 379-401, 433-450, 651-673, 680-702,706-728, 748-770 and 780-802 192222006258 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 192222006259 active site 192222006260 dimerization interface [polypeptide binding]; other site 192222006261 HMMPfam hit to PF01725, Ham1 family, score 1.5e-52 192222006262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 192222006263 Major Facilitator Superfamily; Region: MFS_1; pfam07690 192222006264 putative substrate translocation pore; other site 192222006265 HMMPfam hit to PF00083, Sugar (and other) transporter, score 8.1e-05 192222006266 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.6e-61 192222006267 11 probable transmembrane helices predicted for Cj1375 by TMHMM2.0 at aa 10-32, 39-61, 71-93, 129-151,155-177, 205-227, 237-259, 268-285, 289-306, 327-349 and 353-375 192222006268 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 192222006269 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 192222006270 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 192222006271 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 7.5e-05 192222006272 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.00013 192222006273 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222006274 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 192222006275 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 192222006276 HMMPfam hit to PF03841, L-seryl-tRNA selenium transferase, score 4.4e-220 192222006277 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 192222006278 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 192222006279 G1 box; other site 192222006280 putative GEF interaction site [polypeptide binding]; other site 192222006281 GTP/Mg2+ binding site [chemical binding]; other site 192222006282 Switch I region; other site 192222006283 G2 box; other site 192222006284 G3 box; other site 192222006285 Switch II region; other site 192222006286 G4 box; other site 192222006287 G5 box; other site 192222006288 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 192222006289 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 192222006290 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 1.3e-28 192222006291 PS00017 ATP/GTP-binding site motif A (P-loop) 192222006292 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 192222006293 1 probable transmembrane helix predicted for Cj1381 by TMHMM2.0 at aa 7-29 192222006294 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222006295 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 192222006296 HMMPfam hit to PF00258, Flavodoxin, score 6.8e-43 192222006297 PS00017 ATP/GTP-binding site motif A (P-loop) 192222006298 PS00201 Flavodoxin signature 192222006299 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 192222006300 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 192222006301 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 192222006302 tetramer interface [polypeptide binding]; other site 192222006303 heme binding pocket [chemical binding]; other site 192222006304 NADPH binding site [chemical binding]; other site 192222006305 HMMPfam hit to PF00199, Catalase, score 4.1e-259 192222006306 PS00437 Catalase proximal heme-ligand signature 192222006307 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 192222006308 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 192222006309 HMMPfam hit to PF00023, Ankyrin repeat, score 6.5e-07 192222006310 HMMPfam hit to PF00023, Ankyrin repeat, score 0.0047 192222006311 HMMPfam hit to PF00023, Ankyrin repeat, score 7.4 192222006312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 192222006313 YheO-like PAS domain; Region: PAS_6; pfam08348 192222006314 Helix-turn-helix domains; Region: HTH; cl00088 192222006315 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 192222006316 homotrimer interaction site [polypeptide binding]; other site 192222006317 putative active site [active] 192222006318 HMMPfam hit to PF01042, Endoribonuclease L-PSP,score 1.6e-56 192222006319 PS01094 Uncharacterized protein family UPF0076 signature 192222006320 Original (2000) note: Cj1389, probable transmembrane transport protein pseudogene, len: 1437 bp; similar to e.g. YHCL_ECOLI hypothetical transport protein (455 aa) (approx 45% identity), and DCUC_ECOLI C4-dicarboxylate anaerobic carrier (461 aa) (approx 31% identity). No Hp match; Updated (2006) note: Pfam domain PF03606 C4-dicarboxylate anaerobic carrier identified within CDS. Also, twelve probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Some characterisation work has been carried out within Escherichia coli with acceptable identity score, however,original designation was . Thus, kept within product function. Coding sequence has been updated to reflect the complete amino acid sequence for the encoded protein regardless of its expression. This will cause differences from the amino acid sequence of the previous annotation. Functional classification -Transport/binding proteins - Carbohydrates, organic acids and alcohols; PMID:10525738 192222006321 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 2.1e-56 192222006322 12 probable transmembrane helices predicted for Cj1389 by TMHMM2.0 at aa 4-19, 26-48, 68-90, 110-132,137-159, 191-213, 254-276, 297-317, 337-359, 372-394,427-449 and 456-478 192222006323 cystathionine beta-lyase, bacterial; Region: cysta_beta_ly_B; TIGR01324 192222006324 cystathionine beta-lyase, bacterial; Region: cysta_beta_ly_B; TIGR01324 192222006325 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 192222006326 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 192222006327 catalytic residue [active] 192222006328 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 5.3e-97 192222006329 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site 192222006330 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 192222006331 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 192222006332 tetramer interface [polypeptide binding]; other site 192222006333 active site 192222006334 HMMPfam hit to PF00206, Lyase, score 2.2e-28 192222006335 PS00163 Fumarate lyases signature 192222006336 PS00962 Ribosomal protein S2 signature 1 192222006337 Original (2000) note: Cj1395, possible pseudogene,len: 1338 bp; similar to hypothetical proteins e.g. YXEQ_BACSU (445 aa) (approx 25% identity), and IRG1_MOUSE immune-responsive protein 1 (fragment) (646 aa) (approx 30% identity). No Hp match; Updated (2006) note: Pfam domain PF03972 MmgE/PrpD family identified within CDS. Further support given to product function. No specific characterisation has been carried out with acceptable identity scores yet. Thus, kept within product function. Functional classification - Misc 192222006338 HMMPfam hit to PF03972, MmgE/PrpD family, score 6.2e-57 192222006339 FeoA domain; Region: FeoA; cl00838 192222006340 HMMPfam hit to PF04023, FeoA domain, score 1.4e-18 192222006341 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 192222006342 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 192222006343 G1 box; other site 192222006344 GTP/Mg2+ binding site [chemical binding]; other site 192222006345 Switch I region; other site 192222006346 G2 box; other site 192222006347 G3 box; other site 192222006348 Switch II region; other site 192222006349 G4 box; other site 192222006350 G5 box; other site 192222006351 Nucleoside recognition; Region: Gate; cl00486 192222006352 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 192222006353 Nucleoside recognition; Region: Gate; cl00486 192222006354 HMMPfam hit to PF01926, GTPase of unknown function,score 1.4e-33 192222006355 PS00017 ATP/GTP-binding site motif A (P-loop) 192222006356 HMMPfam hit to PF02421, Ferrous iron transport protein B, score 1.9e-46 192222006357 10 probable transmembrane helices predicted for Cj1398 by TMHMM2.0 at aa 216-238, 266-288, 290-312,327-344, 357-379, 389-407, 449-466, 510-532, 553-575 and 585-607 192222006358 HMMPfam hit to PF07670, Nucleoside recognition,score 2.1e-12 192222006359 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222006360 HMMPfam hit to PF07664, Ferrous iron transport protein B C terminus, score 4.8e-21 192222006361 HMMPfam hit to PF07670, Nucleoside recognition,score 4.1e-19 192222006362 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 192222006363 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 192222006364 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 Kd sub, score 6e-06 192222006365 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 192222006366 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 192222006367 NAD binding site [chemical binding]; other site 192222006368 homotetramer interface [polypeptide binding]; other site 192222006369 homodimer interface [polypeptide binding]; other site 192222006370 substrate binding site [chemical binding]; other site 192222006371 active site 192222006372 HMMPfam hit to PF00106, short chain dehydrogenase,score 4.6e-20 192222006373 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 192222006374 substrate binding site [chemical binding]; other site 192222006375 dimer interface [polypeptide binding]; other site 192222006376 catalytic triad [active] 192222006377 HMMPfam hit to PF00121, Triosephosphate isomerase,score 1.3e-29 192222006378 Phosphoglycerate kinase; Region: PGK; pfam00162 192222006379 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 192222006380 substrate binding site [chemical binding]; other site 192222006381 hinge regions; other site 192222006382 ADP binding site [chemical binding]; other site 192222006383 catalytic site [active] 192222006384 HMMPfam hit to PF00162, Phosphoglycerate kinase,score 1.6e-207 192222006385 PS00111 Phosphoglycerate kinase signature 192222006386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222006387 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 192222006388 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 192222006389 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, C-, score 7.5e-92 192222006390 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site 192222006391 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, NA, score 1.2e-77 192222006392 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 192222006393 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 192222006394 active site 192222006395 (T/H)XGH motif; other site 192222006396 HMMPfam hit to PF01467, Cytidylyltransferase, score 2.2e-24 192222006397 Oligomerisation domain; Region: Oligomerisation; cl00519 192222006398 HMMPfam hit to PF02410, Domain of unknown function DUF143, score 6.4e-28 192222006399 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 192222006400 HMMPfam hit to PF06476, Protein of unknown function (DUF1090), score 4.6e-49 192222006401 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 192222006402 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 192222006403 active site 192222006404 substrate binding site [chemical binding]; other site 192222006405 metal binding site [ion binding]; metal-binding site 192222006406 HMMPfam hit to PF00408,Phosphoglucomutase/phosphomannomutase, C-, score 3.7e-09 192222006407 HMMPfam hit to PF02880,Phosphoglucomutase/phosphomannomutase, al, score 2e-16 192222006408 PS00017 ATP/GTP-binding site motif A (P-loop) 192222006409 HMMPfam hit to PF02879,Phosphoglucomutase/phosphomannomutase, al, score 4.9e-23 192222006410 HMMPfam hit to PF02878,Phosphoglucomutase/phosphomannomutase, al, score 1.3e-42 192222006411 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 192222006412 HMMPfam hit to PF03748, Flagellar basal body-associated protein FliL, score 6.8e-64 192222006413 1 probable transmembrane helix predicted for Cj1408 by TMHMM2.0 at aa 19-41 192222006414 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 192222006415 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase superfami, score 1.4e-14 192222006416 PS00041 Bacterial regulatory proteins, araC family signature 192222006417 1 probable transmembrane helix predicted for Cj1410c by TMHMM2.0 at aa 33-55 192222006418 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 192222006419 Cytochrome P450; Region: p450; pfam00067 192222006420 HMMPfam hit to PF00067, Cytochrome P450, score 4.3e-68 192222006421 PS00086 Cytochrome P450 cysteine heme-iron ligand signature 192222006422 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222006423 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 192222006424 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 192222006425 HMMPfam hit to PF05159, Capsule polysaccharide biosynthesis pro, score 4.1e-137 192222006426 1 probable transmembrane helix predicted for Cj1413c by TMHMM2.0 at aa 157-179 192222006427 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 192222006428 HMMPfam hit to PF05159, Capsule polysaccharide biosynthesis pro, score 2.5e-118 192222006429 HMMPfam hit to PF05159, Capsule polysaccharide biosynthesis pro, score 2.5e-81 192222006430 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 192222006431 ligand-binding site [chemical binding]; other site 192222006432 HMMPfam hit to PF01583, Adenylylsulphate kinase,score 2.7e-17 192222006433 PS00017 ATP/GTP-binding site motif A (P-loop) 192222006434 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 192222006435 active site 192222006436 metal-binding site 192222006437 HMMPfam hit to PF00483, Nucleotidyl transferase,score 0.00053 192222006438 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 192222006439 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 192222006440 conserved cys residue [active] 192222006441 hypothetical protein; Provisional; Region: PRK05849 192222006442 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 192222006443 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 192222006444 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 192222006445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 192222006446 S-adenosylmethionine binding site [chemical binding]; other site 192222006447 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 192222006448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 192222006449 S-adenosylmethionine binding site [chemical binding]; other site 192222006450 PS00213 Lipocalin signature 192222006451 region with low G+C: 26.5% 192222006452 Protein of unknown function (DUF2972); Region: DUF2972; pfam11186 192222006453 Protein of unknown function (DUF2972); Region: DUF2972; pfam11186 192222006454 PS00221 MIP family signature 192222006455 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 192222006456 Substrate binding site; other site 192222006457 Mg++ binding site; other site 192222006458 metal-binding site 192222006459 Mg++ binding site; other site 192222006460 metal-binding site 192222006461 HMMPfam hit to PF00483, Nucleotidyl transferase,score 1.9e-13 192222006462 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 192222006463 dimer interface [polypeptide binding]; other site 192222006464 active site 192222006465 HMMPfam hit to PF01380, SIS domain, score 1.4e-11 192222006466 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 192222006467 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 192222006468 HMMPfam hit to PF00288, GHMP kinases ATP-binding protei, score 5.8e-42 192222006469 PS00012 Phosphopantetheine attachment site 192222006470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222006471 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 192222006472 extended (e) SDRs; Region: SDR_e; cd08946 192222006473 NAD(P) binding site [chemical binding]; other site 192222006474 active site 192222006475 substrate binding site [chemical binding]; other site 192222006476 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 192222006477 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 192222006478 NADP binding site [chemical binding]; other site 192222006479 active site 192222006480 putative substrate binding site [chemical binding]; other site 192222006481 PS00017 ATP/GTP-binding site motif A (P-loop) 192222006482 Cupin domain; Region: Cupin_2; cl09118 192222006483 HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose 3,5-epimerase, score 9.4e-17 192222006484 PS00455 AMP-binding domain signature 192222006485 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 192222006486 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 192222006487 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 192222006488 HMMPfam hit to PF00534, Glycosyl transferases group, score 3.7e-23 192222006489 Protein of unknown function; Region: DUF3971; pfam13116 192222006490 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 192222006491 FeS/SAM binding site; other site 192222006492 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 192222006493 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 192222006494 active site 192222006495 HMMPfam hit to PF00535, Glycosyl transferase, score 7.9e-35 192222006496 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 192222006497 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 192222006498 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 192222006499 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 192222006500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222006501 homodimer interface [polypeptide binding]; other site 192222006502 catalytic residue [active] 192222006503 HMMPfam hit to PF00155, Aminotransferase class I and II, score 2.2e-07 192222006504 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site 192222006505 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 192222006506 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 192222006507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222006508 homodimer interface [polypeptide binding]; other site 192222006509 catalytic residue [active] 192222006510 HMMPfam hit to PF00155, Aminotransferase class I and II, score 9.2e-15 192222006511 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site 192222006512 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 192222006513 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 192222006514 active site 192222006515 ATP-grasp domain; Region: ATP-grasp_4; cl03087 192222006516 PS00225 Crystallins beta and gamma 'Greek key' motif signature 192222006517 HMMPfam hit to PF00535, Glycosyl transferase, score 2.8e-36 192222006518 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 192222006519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222006520 UDP-galactopyranose mutase; Region: GLF; pfam03275 192222006521 HMMPfam hit to PF03275, UDP-galactopyranose mutase,score 2e-114 192222006522 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 192222006523 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 192222006524 active site 192222006525 1 probable transmembrane helix predicted for Cj1440c by TMHMM2.0 at aa 375-397 192222006526 HMMPfam hit to PF00535, Glycosyl transferase, score 2.1e-23 192222006527 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 192222006528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222006529 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 192222006530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222006531 HMMPfam hit to PF03720, UDP-glucose/GDP-mannose dehydrogenase, score 5.2e-06 192222006532 HMMPfam hit to PF00984, UDP-glucose/GDP-mannose dehydrogenase, score 3.7e-29 192222006533 HMMPfam hit to PF03721, UDP-glucose/GDP-mannose dehydrogenase, score 3.8e-33 192222006534 Predicted glycosyltransferase involved in capsule biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG4092 192222006535 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 192222006536 active site 192222006537 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 192222006538 KpsF/GutQ family protein; Region: kpsF; TIGR00393 192222006539 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 192222006540 putative active site [active] 192222006541 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 192222006542 HMMPfam hit to PF00571, CBS domain, score 0.0016 192222006543 HMMPfam hit to PF00571, CBS domain, score 8.1e-10 192222006544 HMMPfam hit to PF01380, SIS domain, score 1.1e-30 192222006545 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 192222006546 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 192222006547 HMMPfam hit to PF02563, Polysaccharide biosynthesis/export protei, score 2.1e-48 192222006548 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 192222006549 HMMPfam hit to PF02706, Chain length determinant protein, score 0.013 192222006550 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 192222006551 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 192222006552 Walker A/P-loop; other site 192222006553 ATP binding site [chemical binding]; other site 192222006554 Q-loop/lid; other site 192222006555 ABC transporter signature motif; other site 192222006556 Walker B; other site 192222006557 D-loop; other site 192222006558 H-loop/switch region; other site 192222006559 HMMPfam hit to PF00005, ABC transporter, score 8.2e-21 192222006560 PS00211 ABC transporters family signature 192222006561 PS00017 ATP/GTP-binding site motif A (P-loop) 192222006562 ABC-2 type transporter; Region: ABC2_membrane; cl11417 192222006563 HMMPfam hit to PF01061, ABC-2 type transporter,score 5.2e-10 192222006564 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 192222006565 PS00017 ATP/GTP-binding site motif A (P-loop) 192222006566 dUTPase; Region: dUTPase_2; pfam08761 192222006567 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 192222006568 5 probable transmembrane helices predicted for Cj1452 by TMHMM2.0 at aa 20-42, 57-79, 81-103, 136-158 and 201-223 192222006569 HMMPfam hit to PF04401, Protein of unknown function (DUF540), score 3e-75 192222006570 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 192222006571 Ligand Binding Site [chemical binding]; other site 192222006572 HMMPfam hit to PF01171, PP-loop family, score 6.8e-90 192222006573 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 192222006574 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 192222006575 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 192222006576 FeS/SAM binding site; other site 192222006577 HMMPfam hit to PF04055, Radical SAM superfamily,score 4.3e-21 192222006578 PS01278 Uncharacterized protein family UPF0004 signature 192222006579 HMMPfam hit to PF00919, Uncharacterized protein family UPF0004, score 9e-37 192222006580 peptide chain release factor 2; Validated; Region: prfB; PRK00578 192222006581 RF-1 domain; Region: RF-1; cl02875 192222006582 RF-1 domain; Region: RF-1; cl02875 192222006583 HMMPfam hit to PF03462, PCRF domain, score 2.7e-50 192222006584 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 2e-67 192222006585 PS00745 Prokaryotic-type class I peptide chain release factors signature 192222006586 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 192222006587 PseudoU_synth_EcTruD: Pseudouridine synthase, TruD family. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_EcTruD; cd02575 192222006588 Permutation of conserved domain; other site 192222006589 active site 192222006590 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 192222006591 HMMPfam hit to PF01142, tRNA pseudouridine synthase D (TruD), score 7.8e-165 192222006592 thiamine monophosphate kinase; Provisional; Region: PRK05731 192222006593 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 192222006594 ATP binding site [chemical binding]; other site 192222006595 dimerization interface [polypeptide binding]; other site 192222006596 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 0.0019 192222006597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222006598 HMMPfam hit to PF03602, Conserved hypothetical protein, score 5.6e-69 192222006599 PS00092 N-6 Adenine-specific DNA methylases signature 192222006600 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 192222006601 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 192222006602 HMMPfam hit to PF02119, Flagellar P-ring protein,score 1.4e-130 192222006603 Rod binding protein; Region: Rod-binding; cl01626 192222006604 FlgN protein; Region: FlgN; cl09176 192222006605 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 192222006606 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 192222006607 HMMPfam hit to PF00460, Flagella basal body rod protein, score 2.1e-05 192222006608 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 6.6e-18 192222006609 Protein of unknown function (DUF2400); Region: DUF2400; cl09884 192222006610 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 192222006611 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 192222006612 7 probable transmembrane helices predicted for Cj1468 by TMHMM2.0 at aa 7-29, 76-98, 105-122, 149-171,183-200, 204-226 and 233-250 192222006613 HMMPfam hit to PF01925, Domain of unknown function DUF81, score 5.8e-34 192222006614 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222006615 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222006616 Original (2000) note: Cj1470c, probable type II protein secretion system F protein pseudogene, len: 1178 bp; similar to e.g. HOFC_ECOLI protein transport protein HOFC (400 aa) (22.7% identity)and GSPF_PSEAE general secretion pathway protein F (405 aa) (23.0% identity). Contains Pfam match to entry PF00482 GSPII_F, Bacterial type II secretion system protein F domain. No Hp match; Updated (2006) note: Pfam domain PF00482 Bacterial type II secretion system protein F domain identified within CDS. Also, four probable transmembrane helices predicted by TMHMM2.0. Further support given to product function. Characterisation paper within Campylobacter attached. Thus, not added to product function. Coding sequence has been updated to reflect the complete amino acid sequence for the encoded protein regardless of its expression. This will cause differences from the amino acid sequence of the previous annotation. Functional classification - Protein and peptide secretion; PMID:12949093 192222006617 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 2.4e-15 192222006618 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 5.9e-21 192222006619 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 192222006620 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 192222006621 Walker A motif; other site 192222006622 ATP binding site [chemical binding]; other site 192222006623 Walker B motif; other site 192222006624 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 5.9e-102 192222006625 PS00662 Bacterial type II secretion system protein E signature 192222006626 PS00017 ATP/GTP-binding site motif A (P-loop) 192222006627 1 probable transmembrane helix predicted for Cj1472c by TMHMM2.0 at aa 20-42 192222006628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 192222006629 AAA domain; Region: AAA_22; pfam13401 192222006630 Walker A motif; other site 192222006631 ATP binding site [chemical binding]; other site 192222006632 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 192222006633 Walker B motif; other site 192222006634 arginine finger; other site 192222006635 PS00017 ATP/GTP-binding site motif A (P-loop) 192222006636 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 192222006637 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 192222006638 HMMPfam hit to PF00263, Bacterial type II and III secretion syst, score 1e-73 192222006639 HMMPfam hit to PF07655, Secretin N-terminal domain,score 1.3e-38 192222006640 HMMPfam hit to PF07660, Secretin and TonB N terminus short domai, score 2.6e-08 192222006641 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 192222006642 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 192222006643 dimer interface [polypeptide binding]; other site 192222006644 PYR/PP interface [polypeptide binding]; other site 192222006645 TPP binding site [chemical binding]; other site 192222006646 substrate binding site [chemical binding]; other site 192222006647 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 192222006648 Domain of unknown function; Region: EKR; cl11037 192222006649 4Fe-4S binding domain; Region: Fer4; cl02805 192222006650 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 192222006651 TPP-binding site [chemical binding]; other site 192222006652 dimer interface [polypeptide binding]; other site 192222006653 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-termina, score 5.1e-104 192222006654 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.00046 192222006655 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222006656 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 7.6e-06 192222006657 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222006658 HMMPfam hit to PF01558, Pyruvate ferredoxin/flavodoxin oxidoredu, score 1.7e-68 192222006659 HMMPfam hit to PF01855, Pyruvate flavodoxin/ferredoxin oxidoredu, score 2.4e-108 192222006660 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 192222006661 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 192222006662 motif II; other site 192222006663 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 2e-19 192222006664 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 192222006665 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 192222006666 ligand binding site [chemical binding]; other site 192222006667 HMMPfam hit to PF00691, OmpA family, score 2.6e-37 192222006668 PS01068 OmpA-like domain 192222006669 HMMPfam hit to PF01389, OmpA-like transmembrane domain, score 0.00072 192222006670 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 192222006671 HMMPfam hit to PF00380, Ribosomal protein S9/S16,score 2.5e-47 192222006672 PS00360 Ribosomal protein S9 signature 192222006673 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 192222006674 23S rRNA interface [nucleotide binding]; other site 192222006675 L3 interface [polypeptide binding]; other site 192222006676 HMMPfam hit to PF00572, Ribosomal protein L13,score 7.7e-54 192222006677 PS00783 Ribosomal protein L13 signature 192222006678 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222006679 putative recombination protein RecB; Provisional; Region: PRK13909 192222006680 Family description; Region: UvrD_C_2; cl15862 192222006681 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 192222006682 HMMPfam hit to PF00580, UvrD/REP helicase, score 3.9e-28 192222006683 PS00017 ATP/GTP-binding site motif A (P-loop) 192222006684 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 192222006685 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 192222006686 FixH; Region: FixH; cl01254 192222006687 1 probable transmembrane helix predicted for Cj1483c by TMHMM2.0 at aa 7-29 192222006688 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222006689 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 192222006690 1 probable transmembrane helix predicted for Cj1485c by TMHMM2.0 at aa 7-26 192222006691 Family of unknown function (DUF4006); Region: DUF4006; pfam13179 192222006692 1 probable transmembrane helix predicted for Cj1486c by TMHMM2.0 at aa 15-37 192222006693 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 192222006694 Cytochrome c; Region: Cytochrom_C; cl11414 192222006695 Cytochrome c; Region: Cytochrom_C; cl11414 192222006696 HMMPfam hit to PF00034, Cytochrome c, score 4.4e-07 192222006697 PS00190 Cytochrome c family heme-binding site signature 192222006698 HMMPfam hit to PF00034, Cytochrome c, score 0.0077 192222006699 PS00190 Cytochrome c family heme-binding site signature 192222006700 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282 192222006701 1 probable transmembrane helix predicted for Cj1488c by TMHMM2.0 at aa 29-51 192222006702 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 192222006703 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 192222006704 HMMPfam hit to PF02433, Cytochrome C oxidase,mono-heme subunit/FixO, score 2.2e-99 192222006705 PS00190 Cytochrome c family heme-binding site signature 192222006706 1 probable transmembrane helix predicted for Cj1489c by TMHMM2.0 at aa 10-32 192222006707 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 192222006708 Low-spin heme binding site [chemical binding]; other site 192222006709 D-pathway; other site 192222006710 Putative water exit pathway; other site 192222006711 Binuclear center (active site) [active] 192222006712 K-pathway; other site 192222006713 Putative proton exit pathway; other site 192222006714 HMMPfam hit to PF00115, Cytochrome C and Quinol oxidase polypeptide, score 3.1e-12 192222006715 PS00077 Heme-copper oxidase catalytic subunit,copper B binding region signature 192222006716 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 192222006717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 192222006718 active site 192222006719 phosphorylation site [posttranslational modification] 192222006720 intermolecular recognition site; other site 192222006721 dimerization interface [polypeptide binding]; other site 192222006722 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 192222006723 DNA binding site [nucleotide binding] 192222006724 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 3.9e-18 192222006725 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.4e-32 192222006726 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 192222006727 PAS domain; Region: PAS_9; pfam13426 192222006728 putative active site [active] 192222006729 heme pocket [chemical binding]; other site 192222006730 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 192222006731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 192222006732 ATP binding site [chemical binding]; other site 192222006733 Mg2+ binding site [ion binding]; other site 192222006734 G-X-G motif; other site 192222006735 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.3e-26 192222006736 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 192222006737 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 192222006738 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 192222006739 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 192222006740 catalytic site [active] 192222006741 subunit interface [polypeptide binding]; other site 192222006742 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 1.5e-57 192222006743 PS00442 Glutamine amidotransferases class-I active site 192222006744 HMMPfam hit to PF00988, Carbamoyl-phosphate synthase small ch, score 5.6e-55 192222006745 Protein of unknown function (DUF507); Region: DUF507; cl01112 192222006746 HMMPfam hit to PF04368, Protein of unknown function (DUF507), score 1.5e-129 192222006747 MgtE intracellular N domain; Region: MgtE_N; cl15244 192222006748 Flagellar FliJ protein; Region: FliJ; pfam02050 192222006749 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 192222006750 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 192222006751 GDP-binding site [chemical binding]; other site 192222006752 ACT binding site; other site 192222006753 IMP binding site; other site 192222006754 HMMPfam hit to PF00709, Adenylosuccinate synthetase, score 1.6e-193 192222006755 PS00513 Adenylosuccinate synthetase active site 192222006756 PS01266 Adenylosuccinate synthetase GTP-binding site 192222006757 putative inner membrane protein; Provisional; Region: PRK11099 192222006758 Sulphur transport; Region: Sulf_transp; cl01018 192222006759 10 probable transmembrane helices predicted for Cj1500 by TMHMM2.0 at aa 19-41, 80-97, 110-129, 139-161,194-216, 226-244, 265-287, 297-319, 331-353 and 368-390 192222006760 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222006761 HMMPfam hit to PF04143, YeeE/YedE family (DUF395),score 1.3e-20 192222006762 HMMPfam hit to PF04143, YeeE/YedE family (DUF395),score 6.5e-17 192222006763 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222006764 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 192222006765 CPxP motif; other site 192222006766 HMMPfam hit to PF01206, SirA-like protein, score 1.6e-27 192222006767 PS01148 Uncharacterized protein family UPF0033 signature 192222006768 Sodium:solute symporter family; Region: SSF; cl00456 192222006769 HMMPfam hit to PF00474, Sodium:solute symporter family, score 2e-120 192222006770 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222006771 Proline dehydrogenase; Region: Pro_dh; cl03282 192222006772 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 192222006773 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 192222006774 Glutamate binding site [chemical binding]; other site 192222006775 NAD binding site [chemical binding]; other site 192222006776 catalytic residues [active] 192222006777 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 1.3e-29 192222006778 PS00070 Aldehyde dehydrogenases cysteine active site 192222006779 PS00687 Aldehyde dehydrogenases glutamic acid active site 192222006780 PS00017 ATP/GTP-binding site motif A (P-loop) 192222006781 HMMPfam hit to PF01619, Proline dehydrogenase,score 5.2e-98 192222006782 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 192222006783 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 192222006784 dimerization interface [polypeptide binding]; other site 192222006785 putative ATP binding site [chemical binding]; other site 192222006786 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 2.9e-21 192222006787 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 192222006788 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 192222006789 CPxP motif; other site 192222006790 HMMPfam hit to PF01206, SirA-like protein, score 5.6e-06 192222006791 Cache domain; Region: Cache_1; pfam02743 192222006792 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 192222006793 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 192222006794 dimer interface [polypeptide binding]; other site 192222006795 putative CheW interface [polypeptide binding]; other site 192222006796 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1.7e-18 192222006797 Helix-turn-helix domains; Region: HTH; cl00088 192222006798 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix protei, score 4.4e-13 192222006799 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 192222006800 HMMPfam hit to PF02634, FdhD/NarQ family, score 9.6e-48 192222006801 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 192222006802 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 192222006803 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 192222006804 4Fe-4S binding domain; Region: Fer4; cl02805 192222006805 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 5e-07 192222006806 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222006807 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 192222006808 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 192222006809 [4Fe-4S] binding site [ion binding]; other site 192222006810 molybdopterin cofactor binding site; other site 192222006811 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 192222006812 molybdopterin cofactor binding site; other site 192222006813 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 1.3e-17 192222006814 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1e-61 192222006815 TGA codes for Selenocysteine in Cj1511c 192222006816 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 do, score 1.9e-19 192222006817 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1 192222006818 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 192222006819 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 192222006820 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 192222006821 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 192222006822 dimer interface [polypeptide binding]; other site 192222006823 active site 192222006824 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 192222006825 catalytic residues [active] 192222006826 substrate binding site [chemical binding]; other site 192222006827 HMMPfam hit to PF00278, Pyridoxal-dependent decarboxylase, C-, score 0.0031 192222006828 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 192222006829 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 192222006830 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 192222006831 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 192222006832 HMMPfam hit to PF07732, Multicopper oxidase, score 3.7e-48 192222006833 HMMPfam hit to PF00394, Multicopper oxidase, score 9.1e-05 192222006834 HMMPfam hit to PF07731, Multicopper oxidase, score 1.5e-18 192222006835 PS00080 Multicopper oxidases signature 2 192222006836 Ubiquitin-like proteins; Region: UBQ; cl00155 192222006837 charged pocket; other site 192222006838 hydrophobic patch; other site 192222006839 HMMPfam hit to PF02597, ThiS family, score 3.1e-13 192222006840 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 192222006841 MoaE homodimer interface [polypeptide binding]; other site 192222006842 MoaD interaction [polypeptide binding]; other site 192222006843 active site residues [active] 192222006844 HMMPfam hit to PF02391, MoaE protein, score 0.00028 192222006845 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 192222006846 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 192222006847 dimer interface [polypeptide binding]; other site 192222006848 putative functional site; other site 192222006849 putative MPT binding site; other site 192222006850 HMMPfam hit to PF03453, MoeA N-terminal region (domain I and II, score 1.3e-69 192222006851 HMMPfam hit to PF00994, Probable molybdopterin binding domain, score 1.6e-30 192222006852 HMMPfam hit to PF03454, MoeA C-terminal region (domain IV), score 4.1e-16 192222006853 1 probable transmembrane helix predicted for Cj1520 by TMHMM2.0 at aa 46-63 192222006854 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 192222006855 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 192222006856 Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]; Region: COG3513 192222006857 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 192222006858 Original (2000) note: Cj1528, probable transmembrane transport protein pseudogene, len: 1191 bp; similar to DCUC_ECOLI C4-dicarboxylate anaerobic carrier (461 aa), approx. 31.6% identity, and YHCL_ECOLI (455 aa) approx. 28.0% identity. No Hp match. Some similarity to Cj1389 (probable transmembrane transport protein pseudogene), approx. 36.7% identity. May extend further upstream; Updated (2006) note: Pfam domain PF03606 C4-dicarboxylate anaerobic carrier identified within CDS. Also, ten probable transmembrane helices predicted for Cj1528 by TMHMM2.0. Further support given to product function. Product is a pseudogene, however, was modified to more specific family member based on motif match. Identity scores were marginal, so was kept within product function. Coding sequence has been updated to reflect the complete amino acid sequence for the encoded protein regardless of its expression. This will cause differences from the amino acid sequence of the previous annotation. Functional classification - Transport/binding proteins - Carbohydrates, organic acids and alcohols; PMID:10525738 192222006859 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 5.5e-08 192222006860 10 probable transmembrane helices predicted for Cj1528 by TMHMM2.0 at aa 4-21, 26-48, 68-90, 119-153,200-222, 248-270, 274-291, 304-326, 352-374 and 444-461 192222006861 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 192222006862 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 192222006863 dimerization interface [polypeptide binding]; other site 192222006864 putative ATP binding site [chemical binding]; other site 192222006865 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 7.4e-38 192222006866 PS00070 Aldehyde dehydrogenases cysteine active site 192222006867 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 3.6e-58 192222006868 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 192222006869 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 192222006870 CoA-binding site [chemical binding]; other site 192222006871 ATP-binding [chemical binding]; other site 192222006872 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222006873 PS00017 ATP/GTP-binding site motif A (P-loop) 192222006874 HMMPfam hit to PF01121, Dephospho-CoA kinase, score 1.6e-29 192222006875 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 192222006876 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 192222006877 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 192222006878 HMMPfam hit to PF01678, Diaminopimelate epimerase,score 1.7e-20 192222006879 PS01326 Diaminopimelate epimerase signature 192222006880 HMMPfam hit to PF01678, Diaminopimelate epimerase,score 1e-07 192222006881 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222006882 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 192222006883 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-ace, score 0.0034 192222006884 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 192222006885 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222006886 Ferritin-like domain; Region: Ferritin; pfam00210 192222006887 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 192222006888 dimerization interface [polypeptide binding]; other site 192222006889 DPS ferroxidase diiron center [ion binding]; other site 192222006890 ion pore; other site 192222006891 HMMPfam hit to PF00210, Ferritin-like domain, score 2.5e-39 192222006892 glucose-6-phosphate isomerase; Provisional; Region: PRK03868 192222006893 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 192222006894 active site 192222006895 dimer interface [polypeptide binding]; other site 192222006896 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 192222006897 dimer interface [polypeptide binding]; other site 192222006898 active site 192222006899 HMMPfam hit to PF00342, Phosphoglucose isomerase,score 1.9e-14 192222006900 PS00174 Phosphoglucose isomerase signature 2 192222006901 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222006902 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 192222006903 active site 192222006904 tetramer interface; other site 192222006905 HMMPfam hit to PF00483, Nucleotidyl transferase,score 3.3e-12 192222006906 acetyl-CoA synthetase; Provisional; Region: PRK00174 192222006907 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 192222006908 AMP-binding enzyme; Region: AMP-binding; cl15778 192222006909 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 192222006910 HMMPfam hit to PF00501, AMP-binding enzyme, score 7.8e-133 192222006911 PS00455 AMP-binding domain signature 192222006912 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 192222006913 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 192222006914 Walker A/P-loop; other site 192222006915 ATP binding site [chemical binding]; other site 192222006916 Q-loop/lid; other site 192222006917 ABC transporter signature motif; other site 192222006918 Walker B; other site 192222006919 D-loop; other site 192222006920 H-loop/switch region; other site 192222006921 PS00294 Prenyl group binding site (CAAX box) 192222006922 HMMPfam hit to PF00005, ABC transporter, score 5.1e-23 192222006923 PS00211 ABC transporters family signature 192222006924 PS00017 ATP/GTP-binding site motif A (P-loop) 192222006925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 192222006926 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 7.8e-07 192222006927 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 192222006928 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 192222006929 LamB/YcsF family; Region: LamB_YcsF; cl00664 192222006930 HMMPfam hit to PF03746, LamB/YcsF family, score 8.3e-172 192222006931 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 192222006932 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 192222006933 HMMPfam hit to PF02682, Allophanate hydrolase subunit, score 3e-62 192222006934 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 192222006935 HMMPfam hit to PF02626, Allophanate hydrolase subunit, score 9.7e-72 192222006936 EamA-like transporter family; Region: EamA; cl01037 192222006937 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 4.2e-19 192222006938 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 192222006939 HMMPfam hit to PF02525, Flavodoxin-like fold, score 2.6e-66 192222006940 Helix-turn-helix domains; Region: HTH; cl00088 192222006941 HMMPfam hit to PF01638, Transcriptional regulator,score 5.1e-29 192222006942 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 192222006943 PS00213 Lipocalin signature 192222006944 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 192222006945 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 192222006946 putative NAD(P) binding site [chemical binding]; other site 192222006947 putative substrate binding site [chemical binding]; other site 192222006948 catalytic Zn binding site [ion binding]; other site 192222006949 structural Zn binding site [ion binding]; other site 192222006950 dimer interface [polypeptide binding]; other site 192222006951 HMMPfam hit to PF00107, Zinc-binding dehydrogenase,score 9e-94 192222006952 PS00059 Zinc-containing alcohol dehydrogenases signature 192222006953 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 192222006954 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 192222006955 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 192222006956 ATP binding site [chemical binding]; other site 192222006957 putative Mg++ binding site [ion binding]; other site 192222006958 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 192222006959 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 7.8e-10 192222006960 HMMPfam hit to PF04313, Type I restriction enzyme R protein N termin, score 6.1e-73 192222006961 AAA domain; Region: AAA_21; pfam13304 192222006962 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222006963 Q-loop/lid; other site 192222006964 ABC transporter signature motif; other site 192222006965 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 192222006966 Walker B; other site 192222006967 D-loop; other site 192222006968 H-loop/switch region; other site 192222006969 PS00017 ATP/GTP-binding site motif A (P-loop) 192222006970 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 192222006971 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 192222006972 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 192222006973 HMMPfam hit to PF01420, Type I restriction modification DNA speci, score 2.5e-06 192222006974 HMMPfam hit to PF01420, Type I restriction modification DNA speci, score 1.3e-31 192222006975 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 192222006976 Divergent AAA domain; Region: AAA_4; pfam04326 192222006977 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 192222006978 HMMPfam hit to PF04326, Divergent AAA domain, score 2.9e-18 192222006979 HsdM N-terminal domain; Region: HsdM_N; pfam12161 192222006980 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 192222006981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222006982 HMMPfam hit to PF02384, N-6 DNA Methylase, score 5e-66 192222006983 PS00092 N-6 Adenine-specific DNA methylases signature 192222006984 HMMPfam hit to PF02506, Type I restriction modification system, M, score 4.6e-94 192222006985 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 192222006986 NADH(P)-binding; Region: NAD_binding_10; pfam13460 192222006987 NAD binding site [chemical binding]; other site 192222006988 substrate binding site [chemical binding]; other site 192222006989 putative active site [active] 192222006990 Helix-turn-helix domains; Region: HTH; cl00088 192222006991 HMMPfam hit to PF01638, Transcriptional regulator,score 1.2e-34 192222006992 1 probable transmembrane helix predicted for Cj1558 by TMHMM2.0 at aa 10-32 192222006993 Original (2000) note: Cj1560, probable membrane protein, len: 274 aa; simlar to hypothetical proteins e.g. Y584_METJA MJ0584 (365 aa), fasta scores; opt: 213 z-score: 246.7 E(): 2.1e-06, 23.5% identity in 294 aa overlap. No Hp match. Note that the similarities continue upstream of the first possible start site (at aa 62), and that this gene may therfore be a pseudogene, with Cj1558 representing the 5' end; Updated (2006) note: Pfam domain PF03773 Predicted permease identified within CDS. Product modified to more specific family member based on motif match. No specific characterisation has been carried out yet, so kept within product function. Also, seven probable transmembrane helix predicted by TMHMM2.0. Functional classification - Transport/binding proteins - Other 192222006994 HMMPfam hit to PF03773, Predicted permease, score 1.8e-21 192222006995 7 probable transmembrane helices predicted for Cj1560 by TMHMM2.0 at aa 15-37, 44-66, 71-90, 157-179,189-206, 213-235 and 250-272 192222006996 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 192222006997 dimerization interface [polypeptide binding]; other site 192222006998 putative DNA binding site [nucleotide binding]; other site 192222006999 putative Zn2+ binding site [ion binding]; other site 192222007000 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 192222007001 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 192222007002 DNA binding residues [nucleotide binding] 192222007003 putative dimer interface [polypeptide binding]; other site 192222007004 HMMPfam hit to PF00376, MerR family regulatory protein, score 1.4e-08 192222007005 Cache domain; Region: Cache_1; pfam02743 192222007006 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 192222007007 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 192222007008 dimer interface [polypeptide binding]; other site 192222007009 putative CheW interface [polypeptide binding]; other site 192222007010 2 probable transmembrane helices predicted for Cj1564 by TMHMM2.0 at aa 20-42 and 291-313 192222007011 HMMPfam hit to PF02743, Cache domain, score 7e-06 192222007012 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 6.4e-21 192222007013 Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15490 192222007014 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.012 192222007015 NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007 192222007016 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 192222007017 HMMPfam hit to PF00361,NADH-Ubiquinone/plastoquinone (complex I), score 2e-50 192222007018 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007019 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 192222007020 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 192222007021 HMMPfam hit to PF00361,NADH-Ubiquinone/plastoquinone (complex I), score 5.3e-59 192222007022 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 192222007023 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 192222007024 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 192222007025 HMMPfam hit to PF06455, NADH dehydrogenase subunit 5 C-terminus, score 0.00052 192222007026 HMMPfam hit to PF00361,NADH-Ubiquinone/plastoquinone (complex, score 1e-89 192222007027 HMMPfam hit to PF00662, NADH-Ubiquinone oxidoreductase (complex, score 1.4e-18 192222007028 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007029 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 192222007030 HMMPfam hit to PF00420,NADH-ubiquinone/plastoquinone oxidoreduct, score 1.5e-33 192222007031 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007032 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 192222007033 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 192222007034 HMMPfam hit to PF00499,NADH-ubiquinone/plastoquinone oxidoreduct, score 2.8e-07 192222007035 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 192222007036 4Fe-4S binding domain; Region: Fer4; cl02805 192222007037 4Fe-4S binding domain; Region: Fer4; cl02805 192222007038 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 2.9e-07 192222007039 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222007040 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.00011 192222007041 NADH dehydrogenase; Region: NADHdh; cl00469 192222007042 HMMPfam hit to PF00146, NADH dehydrogenase, score 8.9e-82 192222007043 PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1 192222007044 NADH dehydrogenase subunit G; Validated; Region: PRK08493 192222007045 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 192222007046 catalytic loop [active] 192222007047 iron binding site [ion binding]; other site 192222007048 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 192222007049 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 192222007050 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 2.2e-05 192222007051 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222007052 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.014 192222007053 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 2e-07 192222007054 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 192222007055 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 192222007056 HMMPfam hit to PF00346, Respiratory-chain NADH dehydrogenase,, score 6.6e-104 192222007057 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 192222007058 HMMPfam hit to PF00329, Respiratory-chain NADH dehydrogenase,, score 1.7e-36 192222007059 PS00542 Respiratory chain NADH dehydrogenase 30 Kd subunit signature 192222007060 NADH dehydrogenase subunit B; Provisional; Region: PRK14817 192222007061 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 192222007062 HMMPfam hit to PF01058, NADH ubiquinone oxidoreductase, 20 Kd sub, score 1.1e-56 192222007063 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 192222007064 HMMPfam hit to PF00507,NADH-ubiquinone/plastoquinone oxidoreduct, score 6.6e-17 192222007065 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 192222007066 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 192222007067 Walker A/P-loop; other site 192222007068 ATP binding site [chemical binding]; other site 192222007069 Q-loop/lid; other site 192222007070 ABC transporter signature motif; other site 192222007071 Walker B; other site 192222007072 D-loop; other site 192222007073 H-loop/switch region; other site 192222007074 HMMPfam hit to PF00005, ABC transporter, score 1.6e-35 192222007075 PS00211 ABC transporters family signature 192222007076 PS00017 ATP/GTP-binding site motif A (P-loop) 192222007077 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 192222007078 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 192222007079 Walker A/P-loop; other site 192222007080 ATP binding site [chemical binding]; other site 192222007081 Q-loop/lid; other site 192222007082 ABC transporter signature motif; other site 192222007083 Walker B; other site 192222007084 D-loop; other site 192222007085 H-loop/switch region; other site 192222007086 HMMPfam hit to PF00005, ABC transporter, score 1.5e-29 192222007087 PS00211 ABC transporters family signature 192222007088 PS00675 Sigma-54 interaction domain ATP-binding region A signature 192222007089 PS00017 ATP/GTP-binding site motif A (P-loop) 192222007090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 192222007091 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.9e-14 192222007092 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 192222007093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 192222007094 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.8e-47 192222007095 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 192222007096 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 192222007097 PS00092 N-6 Adenine-specific DNA methylases signature 192222007098 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 7.9e-72 192222007099 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 192222007100 FAD binding domain; Region: FAD_binding_4; pfam01565 192222007101 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 192222007102 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1 192222007103 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222007104 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.0085 192222007105 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 192222007106 HMMPfam hit to PF02913, FAD linked oxidases,C-terminal domain, score 1.6e-70 192222007107 HMMPfam hit to PF01565, FAD binding domain, score 3.3e-39 192222007108 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 192222007109 heme-binding site [chemical binding]; other site 192222007110 HMMPfam hit to PF00042, Globin, score 3.3e-12 192222007111 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 192222007112 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 192222007113 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 192222007114 Walker A/P-loop; other site 192222007115 ATP binding site [chemical binding]; other site 192222007116 Q-loop/lid; other site 192222007117 ABC transporter signature motif; other site 192222007118 Walker B; other site 192222007119 D-loop; other site 192222007120 H-loop/switch region; other site 192222007121 HMMPfam hit to PF00005, ABC transporter, score 6.3e-33 192222007122 PS00017 ATP/GTP-binding site motif A (P-loop) 192222007123 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 0.00019 192222007124 metabolite-proton symporter; Region: 2A0106; TIGR00883 192222007125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 192222007126 putative substrate translocation pore; other site 192222007127 HMMPfam hit to PF00083, Sugar (and other) transporter, score 2e-19 192222007128 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.4e-21 192222007129 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007130 PS00217 Sugar transport proteins signature 2 192222007131 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 192222007132 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 1.1e-20 192222007133 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 192222007134 rRNA binding site [nucleotide binding]; other site 192222007135 predicted 30S ribosome binding site; other site 192222007136 HMMPfam hit to PF00575, S1 RNA binding domain,score 1.1e-10 192222007137 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 192222007138 HMMPfam hit to PF00444, Ribosomal protein L36,score 7.5e-17 192222007139 PS00828 Ribosomal protein L36 signature 192222007140 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 192222007141 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 192222007142 HMMPfam hit to PF00416, Ribosomal protein S13/S18,score 1.5e-50 192222007143 PS00646 Ribosomal protein S13 signature 192222007144 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 192222007145 HMMPfam hit to PF00411, Ribosomal protein S11,score 6.2e-56 192222007146 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 192222007147 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 192222007148 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 192222007149 RNA binding surface [nucleotide binding]; other site 192222007150 HMMPfam hit to PF00163, Ribosomal protein S4/S9 N-terminal domai, score 5.4e-25 192222007151 PS00632 Ribosomal protein S4 signature 192222007152 HMMPfam hit to PF01479, S4 domain, score 1.3e-23 192222007153 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 192222007154 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 192222007155 alphaNTD homodimer interface [polypeptide binding]; other site 192222007156 alphaNTD - beta interaction site [polypeptide binding]; other site 192222007157 alphaNTD - beta' interaction site [polypeptide binding]; other site 192222007158 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 192222007159 HMMPfam hit to PF01193, RNA polymerase Rpb3/Rpb11 dimerisation, score 3.8e-15 192222007160 HMMPfam hit to PF01000, RNA polymerase Rpb3/RpoA insert domain, score 4.9e-43 192222007161 HMMPfam hit to PF03118, Bacterial RNA polymerase,alpha chain C, score 1.2e-22 192222007162 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 192222007163 HMMPfam hit to PF01196, Ribosomal protein L17,score 1.3e-53 192222007164 PS01167 Ribosomal protein L17 signature 192222007165 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 192222007166 ATP phosphoribosyltransferase; Region: HisG; cl15266 192222007167 HisG, C-terminal domain; Region: HisG_C; cl06867 192222007168 HMMPfam hit to PF01634, ATP phosphoribosyltransferase, score 4.3e-67 192222007169 histidinol dehydrogenase; Region: hisD; TIGR00069 192222007170 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 192222007171 NAD binding site [chemical binding]; other site 192222007172 dimerization interface [polypeptide binding]; other site 192222007173 product binding site; other site 192222007174 substrate binding site [chemical binding]; other site 192222007175 zinc binding site [ion binding]; other site 192222007176 catalytic residues [active] 192222007177 HMMPfam hit to PF00815, Histidinol dehydrogenase,score 1.1e-233 192222007178 PS00611 Histidinol dehydrogenase signature 192222007179 PS00017 ATP/GTP-binding site motif A (P-loop) 192222007180 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 192222007181 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 192222007182 active site 192222007183 motif I; other site 192222007184 motif II; other site 192222007185 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 192222007186 putative active site pocket [active] 192222007187 4-fold oligomerization interface [polypeptide binding]; other site 192222007188 metal binding residues [ion binding]; metal-binding site 192222007189 3-fold/trimer interface [polypeptide binding]; other site 192222007190 HMMPfam hit to PF00475, Imidazoleglycerol-phosphate dehydratase, score 7e-88 192222007191 PS00954 Imidazoleglycerol-phosphate dehydratase signature 1 192222007192 PS00955 Imidazoleglycerol-phosphate dehydratase signature 2 192222007193 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 192222007194 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 192222007195 putative active site [active] 192222007196 oxyanion strand; other site 192222007197 catalytic triad [active] 192222007198 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 4.8e-34 192222007199 PS00442 Glutamine amidotransferases class-I active site 192222007200 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 192222007201 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 192222007202 catalytic residues [active] 192222007203 HMMPfam hit to PF00977, Histidine biosynthesis protein, score 2.9e-103 192222007204 Protein of unknown function (DUF511); Region: DUF511; cl01114 192222007205 HMMPfam hit to PF04373, Protein of unknown function (DUF511), score 2.8e-201 192222007206 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 192222007207 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 192222007208 substrate binding site [chemical binding]; other site 192222007209 glutamase interaction surface [polypeptide binding]; other site 192222007210 HMMPfam hit to PF00977, Histidine biosynthesis protein, score 2.6e-115 192222007211 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 192222007212 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 192222007213 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 192222007214 HMMPfam hit to PF01502, Phosphoribosyl-AMP cyclohydrolase, score 5.5e-43 192222007215 HMMPfam hit to PF01503, Phosphoribosyl-ATP pyrophosphohydrolase, score 2.6e-44 192222007216 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 192222007217 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 192222007218 putative trimer interface [polypeptide binding]; other site 192222007219 putative CoA binding site [chemical binding]; other site 192222007220 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007221 antiporter inner membrane protein; Provisional; Region: PRK11670 192222007222 Domain of unknown function DUF59; Region: DUF59; cl00941 192222007223 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 192222007224 PS00017 ATP/GTP-binding site motif A (P-loop) 192222007225 HMMPfam hit to PF01883, Domain of unknown function DUF59, score 2.9e-05 192222007226 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 192222007227 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 192222007228 substrate binding site; other site 192222007229 dimer interface; other site 192222007230 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 192222007231 homotrimer interaction site [polypeptide binding]; other site 192222007232 zinc binding site [ion binding]; other site 192222007233 CDP-binding sites; other site 192222007234 HMMPfam hit to PF01128, Uncharacterized protein family UPF0007, score 1.3e-11 192222007235 HMMPfam hit to PF02542, YgbB family, score 1.9e-73 192222007236 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 192222007237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 192222007238 active site 192222007239 intermolecular recognition site; other site 192222007240 dimerization interface [polypeptide binding]; other site 192222007241 HMMPfam hit to PF00072, Response regulator receiver domain, score 8.9e-05 192222007242 ATP sulfurylase (sulfate adenylyltransferase) [Inorganic ion transport and metabolism]; Region: MET3; COG2046 192222007243 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 192222007244 active site 192222007245 nucleotide binding site [chemical binding]; other site 192222007246 HIGH motif; other site 192222007247 KMSKS motif; other site 192222007248 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 192222007249 tetramer interfaces [polypeptide binding]; other site 192222007250 binuclear metal-binding site [ion binding]; other site 192222007251 HMMPfam hit to PF04608,Phosphatidylglycerophosphatase A, score 2.9e-86 192222007252 3 probable transmembrane helices predicted for Cj1610 by TMHMM2.0 at aa 20-54, 80-102 and 136-158 192222007253 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 192222007254 HMMPfam hit to PF01649, Ribosomal protein S20,score 1.5e-27 192222007255 peptide chain release factor 1; Validated; Region: prfA; PRK00591 192222007256 RF-1 domain; Region: RF-1; cl02875 192222007257 RF-1 domain; Region: RF-1; cl02875 192222007258 HMMPfam hit to PF03462, PCRF domain, score 3.3e-64 192222007259 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 3.8e-74 192222007260 PS00745 Prokaryotic-type class I peptide chain release factors signature 192222007261 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 192222007262 heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109 192222007263 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 192222007264 HMMPfam hit to PF01243, Pyridoxamine 5'-phosphate oxidase, score 1.5e-17 192222007265 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 192222007266 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 192222007267 N-terminal plug; other site 192222007268 ligand-binding site [chemical binding]; other site 192222007269 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 2e-14 192222007270 HMMPfam hit to PF00593, TonB dependent receptor,score 3.8e-21 192222007271 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 192222007272 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 192222007273 ABC-ATPase subunit interface; other site 192222007274 dimer interface [polypeptide binding]; other site 192222007275 putative PBP binding regions; other site 192222007276 9 probable transmembrane helices predicted for Cj1615 by TMHMM2.0 at aa 12-31, 63-85, 92-110, 115-137,144-166, 186-205, 236-258, 273-290 and 297-319 192222007277 HMMPfam hit to PF01032, FecCD transport family,score 7.2e-77 192222007278 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 192222007279 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 192222007280 Walker A/P-loop; other site 192222007281 ATP binding site [chemical binding]; other site 192222007282 Q-loop/lid; other site 192222007283 ABC transporter signature motif; other site 192222007284 Walker B; other site 192222007285 D-loop; other site 192222007286 H-loop/switch region; other site 192222007287 HMMPfam hit to PF00005, ABC transporter, score 2e-47 192222007288 PS00017 ATP/GTP-binding site motif A (P-loop) 192222007289 PS00211 ABC transporters family signature 192222007290 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 192222007291 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 192222007292 putative binding site residues; other site 192222007293 HMMPfam hit to PF01497, Periplasmic binding protein, score 2e-31 192222007294 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 192222007295 FeS/SAM binding site; other site 192222007296 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 192222007297 HMMPfam hit to PF04055, Radical SAM superfamily,score 1.7e-06 192222007298 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 192222007299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 192222007300 putative substrate translocation pore; other site 192222007301 HMMPfam hit to PF00083, Sugar (and other) transporter, score 4e-45 192222007302 12 probable transmembrane helices predicted for Cj1619 by TMHMM2.0 at aa 13-35, 50-72, 85-102, 112-134,155-174, 184-203, 230-252, 267-289, 298-317, 327-349,361-383 and 393-412 192222007303 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 7.3e-21 192222007304 PS00217 Sugar transport proteins signature 2 192222007305 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 192222007306 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 192222007307 minor groove reading motif; other site 192222007308 helix-hairpin-helix signature motif; other site 192222007309 substrate binding pocket [chemical binding]; other site 192222007310 active site 192222007311 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 2.5e-23 192222007312 HMMPfam hit to PF00633, Helix-hairpin-helix motif,score 9.8e-07 192222007313 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007314 1 probable transmembrane helix predicted for Cj1621 by TMHMM2.0 at aa 7-29 192222007315 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 192222007316 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 192222007317 catalytic motif [active] 192222007318 Zn binding site [ion binding]; other site 192222007319 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 192222007320 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminase, score 4.9e-27 192222007321 2 probable transmembrane helices predicted for Cj1623 by TMHMM2.0 at aa 97-116 and 121-143 192222007322 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 192222007323 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 192222007324 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 192222007325 HMMPfam hit to PF03313, Serine dehydratase alpha chain, score 8.3e-143 192222007326 HMMPfam hit to PF03315, Serine dehydratase beta chain, score 8.4e-47 192222007327 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 192222007328 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 192222007329 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007330 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007331 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 192222007332 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 192222007333 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 192222007334 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 192222007335 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 9.2e-42 192222007336 3 probable transmembrane helices predicted for Cj1628 by TMHMM2.0 at aa 10-28, 61-83 and 103-125 192222007337 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 192222007338 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 6.5e-41 192222007339 1 probable transmembrane helix predicted for Cj1629 by TMHMM2.0 at aa 12-34 192222007340 Gram-negative bacterial tonB protein; Region: TonB; cl10048 192222007341 1 probable transmembrane helix predicted for Cj1630 by TMHMM2.0 at aa 12-29 192222007342 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 3e-13 192222007343 Protein of unknown function (DUF3135); Region: DUF3135; pfam11333 192222007344 PS00018 EF-hand calcium-binding domain 192222007345 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 192222007346 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 192222007347 Ligand Binding Site [chemical binding]; other site 192222007348 PS00190 Cytochrome c family heme-binding site signature 192222007349 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 192222007350 Tetramer interface [polypeptide binding]; other site 192222007351 active site 192222007352 FMN-binding site [chemical binding]; other site 192222007353 HMMPfam hit to PF01264, Chorismate synthase, score 6.3e-158 192222007354 PS00788 Chorismate synthase signature 2 192222007355 PS00787 Chorismate synthase signature 1 192222007356 ribonuclease III; Reviewed; Region: rnc; PRK00102 192222007357 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 192222007358 dimerization interface [polypeptide binding]; other site 192222007359 active site 192222007360 metal binding site [ion binding]; metal-binding site 192222007361 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 192222007362 dsRNA binding site [nucleotide binding]; other site 192222007363 HMMPfam hit to PF00035, Double-stranded RNA binding motif, score 2.1e-19 192222007364 HMMPfam hit to PF00636, RNase3 domain, score 1.2e-41 192222007365 PS00517 Ribonuclease III family signature 192222007366 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 192222007367 RNA/DNA hybrid binding site [nucleotide binding]; other site 192222007368 active site 192222007369 HMMPfam hit to PF00075, RNase H, score 3.7e-46 192222007370 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 192222007371 TPR motif; other site 192222007372 binding surface 192222007373 Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have...; Region: ZZ; cl00295 192222007374 Zinc-binding sites [ion binding]; other site 192222007375 zinc cluster 1 [ion binding]; other site 192222007376 putative charged binding surface; other site 192222007377 putative hydrophobic binding surface; other site 192222007378 zinc cluster 2 [ion binding]; other site 192222007379 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.0026 192222007380 1 probable transmembrane helix predicted for Cj1637c by TMHMM2.0 at aa 12-34 192222007381 DNA primase, catalytic core; Region: dnaG; TIGR01391 192222007382 CHC2 zinc finger; Region: zf-CHC2; cl15369 192222007383 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 192222007384 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 192222007385 active site 192222007386 metal binding site [ion binding]; metal-binding site 192222007387 interdomain interaction site; other site 192222007388 HMMPfam hit to PF01807, CHC2 zinc finger, score 4.2e-50 192222007389 HMMPfam hit to PF01751, Toprim domain, score 3.7e-18 192222007390 NifU-like domain; Region: NifU; cl00484 192222007391 HMMPfam hit to PF01106, NifU-like domain, score 2.7e-20 192222007392 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007393 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 192222007394 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 192222007395 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 192222007396 HMMPfam hit to PF01225, Mur ligase family,catalytic domain, score 6.2e-36 192222007397 PS01011 Folylpolyglutamate synthase signature 1 192222007398 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007399 HMMPfam hit to PF02875, Mur ligase family,glutamate ligase doma, score 9.8e-27 192222007400 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 192222007401 HMMPfam hit to PF02575, Uncharacterised BCR, YbaB family COG0718, score 9.9e-35 192222007402 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 192222007403 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 192222007404 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 192222007405 substrate binding pocket [chemical binding]; other site 192222007406 chain length determination region; other site 192222007407 substrate-Mg2+ binding site; other site 192222007408 catalytic residues [active] 192222007409 aspartate-rich region 1; other site 192222007410 active site lid residues [active] 192222007411 aspartate-rich region 2; other site 192222007412 HMMPfam hit to PF00348, Polyprenyl synthetase,score 8.6e-63 192222007413 PS00723 Polyprenyl synthetases signature 1 192222007414 PS00444 Polyprenyl synthetases signature 2 192222007415 transketolase; Reviewed; Region: PRK05899 192222007416 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 192222007417 TPP-binding site [chemical binding]; other site 192222007418 dimer interface [polypeptide binding]; other site 192222007419 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 192222007420 PYR/PP interface [polypeptide binding]; other site 192222007421 dimer interface [polypeptide binding]; other site 192222007422 TPP binding site [chemical binding]; other site 192222007423 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 192222007424 HMMPfam hit to PF00456, Transketolase, thiamine diphosphate b, score 1.1e-148 192222007425 PS00801 Transketolase signature 1 192222007426 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 3.3e-50 192222007427 PS00802 Transketolase signature 2 192222007428 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 0.00035 192222007429 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 192222007430 Permease; Region: Permease; cl00510 192222007431 6 probable transmembrane helices predicted for Cj1646 by TMHMM2.0 at aa 122-141, 161-183, 193-215,259-281, 306-325 and 346-368 192222007432 HMMPfam hit to PF02405, Domain of unknown function DUF140, score 1.4e-80 192222007433 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007434 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 192222007435 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 192222007436 Walker A/P-loop; other site 192222007437 ATP binding site [chemical binding]; other site 192222007438 Q-loop/lid; other site 192222007439 ABC transporter signature motif; other site 192222007440 Walker B; other site 192222007441 D-loop; other site 192222007442 H-loop/switch region; other site 192222007443 HMMPfam hit to PF00005, ABC transporter, score 4e-51 192222007444 PS00017 ATP/GTP-binding site motif A (P-loop) 192222007445 PS00211 ABC transporters family signature 192222007446 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 192222007447 mce related protein; Region: MCE; pfam02470 192222007448 1 probable transmembrane helix predicted for Cj1648 by TMHMM2.0 at aa 7-29 192222007449 HMMPfam hit to PF02470, mce related protein, score 0.00095 192222007450 Protein of unknown function (DUF330); Region: DUF330; cl01135 192222007451 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007452 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 192222007453 active site 192222007454 HMMPfam hit to PF00557, metallopeptidase family M24, score 1.5e-59 192222007455 PS00680 Methionine aminopeptidase subfamily 1 signature 192222007456 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 192222007457 HMMPfam hit to PF01177, Asp/Glu/Hydantoin racemase,score 2e-90 192222007458 PS00924 Aspartate and glutamate racemases signature 2 192222007459 PS00923 Aspartate and glutamate racemases signature 1 192222007460 PS00225 Crystallins beta and gamma 'Greek key' motif signature 192222007461 NlpC/P60 family; Region: NLPC_P60; cl11438 192222007462 HMMPfam hit to PF00877, NlpC/P60 family, score 7.8e-40 192222007463 1 probable transmembrane helix predicted for Cj1653c by TMHMM2.0 at aa 4-23 192222007464 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007465 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 192222007466 HMMPfam hit to PF06965, Na+/H+ antiporter, score 2.2e-229 192222007467 PS00284 Serpins signature 192222007468 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 192222007469 HMMPfam hit to PF06965, Na+/H+ antiporter, score 1.1e-239 192222007470 Putative motility protein; Region: YjfB_motility; pfam14070 192222007471 Iron permease FTR1 family; Region: FTR1; cl00475 192222007472 HMMPfam hit to PF03239, Iron permease FTR1 family,score 2.3e-08 192222007473 7 probable transmembrane helices predicted for Cj1658 by TMHMM2.0 at aa 439-458, 470-492, 502-524,551-573, 583-604, 616-633 and 668-685 192222007474 Fe2+ transport protein; Region: Iron_transport; cl01377 192222007475 1 probable transmembrane helix predicted for Cj1659 by TMHMM2.0 at aa 5-27 192222007476 Predicted membrane protein [Function unknown]; Region: COG4393 192222007477 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 192222007478 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 192222007479 8 probable transmembrane helices predicted for Cj1660 by TMHMM2.0 at aa 4-21, 28-50, 60-79, 86-105,120-142, 154-176, 196-218 and 244-266 192222007480 HMMPfam hit to PF04945, YHS domain, score 1.1e-17 192222007481 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 192222007482 FtsX-like permease family; Region: FtsX; cl15850 192222007483 4 probable transmembrane helices predicted for Cj1661 by TMHMM2.0 at aa 20-42, 303-325, 359-381 and 391-413 192222007484 HMMPfam hit to PF02687, Predicted permease, score 2.3e-29 192222007485 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007486 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 192222007487 FtsX-like permease family; Region: FtsX; cl15850 192222007488 4 probable transmembrane helices predicted for Cj1662 by TMHMM2.0 at aa 21-43, 250-272, 301-323 and 333-355 192222007489 HMMPfam hit to PF02687, Predicted permease, score 1.4e-30 192222007490 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 192222007491 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 192222007492 Walker A/P-loop; other site 192222007493 ATP binding site [chemical binding]; other site 192222007494 Q-loop/lid; other site 192222007495 ABC transporter signature motif; other site 192222007496 Walker B; other site 192222007497 D-loop; other site 192222007498 H-loop/switch region; other site 192222007499 HMMPfam hit to PF00005, ABC transporter, score 1.1e-63 192222007500 PS00017 ATP/GTP-binding site motif A (P-loop) 192222007501 PS00211 ABC transporters family signature 192222007502 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 192222007503 catalytic residues [active] 192222007504 PS00194 Thioredoxin family active site 192222007505 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 192222007506 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007507 Protein of unknown function, DUF; Region: DUF411; cl01142 192222007508 HMMPfam hit to PF04214, Protein of unknown function, DUF, score 4.7e-60 192222007509 1 probable transmembrane helix predicted for Cj1668c by TMHMM2.0 at aa 4-26 192222007510 DNA ligase; Provisional; Region: PRK09125 192222007511 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 192222007512 DNA binding site [nucleotide binding] 192222007513 active site 192222007514 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 192222007515 DNA binding site [nucleotide binding] 192222007516 HMMPfam hit to PF01068, ATP dependent DNA ligase domain, score 8.1e-08 192222007517 PS00333 ATP-dependent DNA ligase signature 2 192222007518 AMIN domain; Region: AMIN; pfam11741 192222007519 1 probable transmembrane helix predicted for Cj1671c by TMHMM2.0 at aa 2-21 192222007520 enolase; Provisional; Region: eno; PRK00077 192222007521 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 192222007522 dimer interface [polypeptide binding]; other site 192222007523 metal binding site [ion binding]; metal-binding site 192222007524 substrate binding pocket [chemical binding]; other site 192222007525 HMMPfam hit to PF00113, Enolase, C-terminal TIM barrel domain, score 5e-135 192222007526 HMMPfam hit to PF03952, Enolase, N-terminal domain,score 8.4e-59 192222007527 recombinase A; Provisional; Region: recA; PRK09354 192222007528 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 192222007529 hexamer interface [polypeptide binding]; other site 192222007530 Walker A motif; other site 192222007531 ATP binding site [chemical binding]; other site 192222007532 Walker B motif; other site 192222007533 HMMPfam hit to PF00154, recA bacterial DNA recombination protein, score 1.2e-237 192222007534 PS00321 recA signature 192222007535 PS00017 ATP/GTP-binding site motif A (P-loop) 192222007536 NMT1-like family; Region: NMT1_2; cl15260 192222007537 HMMPfam hit to PF02642, Uncharacterized ACR,COG2107, score 1.9e-107 192222007538 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 192222007539 HMMPfam hit to PF01313, Bacterial export proteins,family, score 4.6e-32 192222007540 2 probable transmembrane helices predicted for Cj1675 by TMHMM2.0 at aa 15-37 and 49-71 192222007541 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13904 192222007542 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 192222007543 HMMPfam hit to PF02873,UDP-N-acetylenolpyruvoylglucosamine reductas, score 6.6e-30 192222007544 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 192222007545 HMMPfam hit to PF03797, Autotransporter beta-domain, score 5.9e-38 192222007546 TPR repeat; Region: TPR_11; pfam13414 192222007547 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 2.8 192222007548 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.00092 192222007549 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 192222007550 active site 192222007551 HMMPfam hit to PF00459, Inositol monophosphatase family, score 3.5e-29 192222007552 PS00629 Inositol monophosphatase family signature 1 192222007553 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 192222007554 dimer interface [polypeptide binding]; other site 192222007555 Citrate synthase; Region: Citrate_synt; pfam00285 192222007556 active site 192222007557 citrylCoA binding site [chemical binding]; other site 192222007558 NADH binding [chemical binding]; other site 192222007559 cationic pore residues; other site 192222007560 oxalacetate/citrate binding site [chemical binding]; other site 192222007561 coenzyme A binding site [chemical binding]; other site 192222007562 catalytic triad [active] 192222007563 HMMPfam hit to PF00285, Citrate synthase, score 2.2e-174 192222007564 PS00480 Citrate synthase signature 192222007565 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 192222007566 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 192222007567 biotin synthase; Provisional; Region: PRK08508 192222007568 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 192222007569 FeS/SAM binding site; other site 192222007570 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 192222007571 HMMPfam hit to PF06968, Biotin and Thiamin Synthesis associated d, score 1e-25 192222007572 HMMPfam hit to PF04055, Radical SAM superfamily,score 9.8e-20 192222007573 DNA topoisomerase I; Validated; Region: PRK05582 192222007574 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 192222007575 active site 192222007576 interdomain interaction site; other site 192222007577 putative metal-binding site [ion binding]; other site 192222007578 nucleotide binding site [chemical binding]; other site 192222007579 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 192222007580 domain I; other site 192222007581 DNA binding groove [nucleotide binding] 192222007582 phosphate binding site [ion binding]; other site 192222007583 domain II; other site 192222007584 domain III; other site 192222007585 nucleotide binding site [chemical binding]; other site 192222007586 catalytic site [active] 192222007587 domain IV; other site 192222007588 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 192222007589 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 192222007590 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 0.0034 192222007591 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 8.7e-14 192222007592 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 4e-17 192222007593 HMMPfam hit to PF01131, DNA topoisomerase, score 3.7e-168 192222007594 PS00396 Prokaryotic DNA topoisomerase I active site 192222007595 HMMPfam hit to PF01751, Toprim domain, score 4.5e-32 192222007596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 192222007597 putative substrate translocation pore; other site 192222007598 12 probable transmembrane helices predicted for Cj1687 by TMHMM2.0 at aa 31-53, 80-102, 115-137, 141-160,172-194, 199-221, 240-259, 279-301, 308-327, 332-354,367-389 and 399-416 192222007599 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.5e-47 192222007600 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007601 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 192222007602 SecY translocase; Region: SecY; pfam00344 192222007603 HMMPfam hit to PF00344, eubacterial secY protein,score 5.2e-113 192222007604 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature 192222007605 PS00756 Protein secY signature 2 192222007606 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 192222007607 HMMPfam hit to PF01305, Ribosomal protein L15 amino terminal re, score 1.5e-41 192222007608 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 192222007609 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 192222007610 HMMPfam hit to PF03719, Ribosomal protein S5,C-terminal domai, score 1.8e-23 192222007611 HMMPfam hit to PF00333, Ribosomal protein S5,N-terminal domai, score 6.4e-34 192222007612 PS00585 Ribosomal protein S5 signature 192222007613 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 192222007614 5S rRNA interface [nucleotide binding]; other site 192222007615 23S rRNA interface [nucleotide binding]; other site 192222007616 L5 interface [polypeptide binding]; other site 192222007617 HMMPfam hit to PF00861, Ribosomal L18p/L5e family,score 8.6e-27 192222007618 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 192222007619 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 192222007620 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 192222007621 HMMPfam hit to PF00347, Ribosomal protein L6, score 2.6e-30 192222007622 PS00525 Ribosomal protein L6 signature 1 192222007623 HMMPfam hit to PF00347, Ribosomal protein L6, score 3e-07 192222007624 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 192222007625 HMMPfam hit to PF00410, Ribosomal protein S8, score 2.7e-52 192222007626 PS00294 Prenyl group binding site (CAAX box) 192222007627 PS00053 Ribosomal protein S8 signature 192222007628 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 192222007629 HMMPfam hit to PF00253, Ribosomal protein S14p/S29e, score 6.5e-20 192222007630 PS00527 Ribosomal protein S14 signature 192222007631 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 192222007632 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 192222007633 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 192222007634 HMMPfam hit to PF00673, ribosomal L5P family C-terminus, score 6e-47 192222007635 HMMPfam hit to PF00281, Ribosomal protein L5, score 2.1e-21 192222007636 PS00358 Ribosomal protein L5 signature 192222007637 KOW motif; Region: KOW; cl00354 192222007638 HMMPfam hit to PF00467, KOW motif, score 9.3e-11 192222007639 PS01108 Ribosomal protein L24 signature 192222007640 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 192222007641 HMMPfam hit to PF00238, Ribosomal protein L14p/L23e, score 3.4e-77 192222007642 PS00049 Ribosomal protein L14 signature 192222007643 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 192222007644 HMMPfam hit to PF00366, Ribosomal protein S17,score 1.1e-23 192222007645 PS00056 Ribosomal protein S17 signature 192222007646 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 192222007647 putative translocon interaction site; other site 192222007648 23S rRNA interface [nucleotide binding]; other site 192222007649 signal recognition particle (SRP54) interaction site; other site 192222007650 L23 interface [polypeptide binding]; other site 192222007651 trigger factor interaction site; other site 192222007652 HMMPfam hit to PF00831, Ribosomal L29 protein,score 1.5e-19 192222007653 PS00579 Ribosomal protein L29 signature 192222007654 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 192222007655 23S rRNA interface [nucleotide binding]; other site 192222007656 5S rRNA interface [nucleotide binding]; other site 192222007657 putative antibiotic binding site [chemical binding]; other site 192222007658 L25 interface [polypeptide binding]; other site 192222007659 L27 interface [polypeptide binding]; other site 192222007660 HMMPfam hit to PF00252, Ribosomal protein L16,score 2.7e-82 192222007661 PS00701 Ribosomal protein L16 signature 2 192222007662 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 192222007663 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 192222007664 G-X-X-G motif; other site 192222007665 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 192222007666 HMMPfam hit to PF00189, Ribosomal protein S3,C-terminal domai, score 2.8e-49 192222007667 PS00548 Ribosomal protein S3 signature 192222007668 HMMPfam hit to PF07650, KH domain, score 1.4e-17 192222007669 HMMPfam hit to PF00417, Ribosomal protein S3,N-terminal domai, score 1.9e-24 192222007670 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 192222007671 putative translocon binding site; other site 192222007672 protein-rRNA interface [nucleotide binding]; other site 192222007673 HMMPfam hit to PF00237, Ribosomal protein L22p/L17e, score 3.7e-29 192222007674 PS00464 Ribosomal protein L22 signature 192222007675 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 192222007676 HMMPfam hit to PF00203, Ribosomal protein S19,score 1.7e-43 192222007677 PS00323 Ribosomal protein S19 signature 192222007678 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 192222007679 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 192222007680 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 192222007681 HMMPfam hit to PF03947, Ribosomal Proteins L2,C-terminal doma, score 1.7e-85 192222007682 PS00467 Ribosomal protein L2 signature 192222007683 HMMPfam hit to PF00181, Ribosomal Proteins L2, RNA binding dom, score 4.1e-40 192222007684 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 192222007685 HMMPfam hit to PF00276, Ribosomal protein L23,score 2.7e-09 192222007686 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 192222007687 HMMPfam hit to PF00573, Ribosomal protein L4/L1 family, score 1.6e-49 192222007688 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 192222007689 HMMPfam hit to PF00297, Ribosomal protein L3, score 2.3e-18 192222007690 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 192222007691 HMMPfam hit to PF00338, Ribosomal protein S10p/S20e, score 9.1e-49 192222007692 PS00361 Ribosomal protein S10 signature 192222007693 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 192222007694 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 192222007695 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 192222007696 active site 192222007697 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 2.2e-07 192222007698 PS01149 Rsu family of pseudouridine synthase signature 192222007699 HMMPfam hit to PF01479, S4 domain, score 3.6e-09 192222007700 PS00881 Protein splicing signature 192222007701 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 192222007702 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 192222007703 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 192222007704 HMMPfam hit to PF07521, RNA-metabolising metallo-beta-lactamase, score 4.4e-11 192222007705 PS01292 Uncharacterized protein family UPF0036 signature 192222007706 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 1.8e-26 192222007707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 192222007708 HMMPfam hit to PF00398, Ribosomal RNA adenine dimethylase, score 1.4e-42 192222007709 PS00322 Histone H3 signature 1 192222007710 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 192222007711 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14462 192222007712 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 192222007713 FeS/SAM binding site; other site 192222007714 HMMPfam hit to PF04055, Radical SAM superfamily,score 1.9e-13 192222007715 1 probable transmembrane helix predicted for Cj1714 by TMHMM2.0 at aa 6-28 192222007716 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 192222007717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 192222007718 Coenzyme A binding pocket [chemical binding]; other site 192222007719 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.7e-13 192222007720 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 192222007721 substrate binding site [chemical binding]; other site 192222007722 HMMPfam hit to PF00694, Aconitase C-terminal domain, score 7.2e-54 192222007723 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 192222007724 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 192222007725 substrate binding site [chemical binding]; other site 192222007726 ligand binding site [chemical binding]; other site 192222007727 HMMPfam hit to PF00330, Aconitase family (aconitate hydratase), score 3.1e-218 192222007728 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007729 PS01244 Aconitase family signature 2 192222007730 PS00450 Aconitase family signature 1 192222007731 tartrate dehydrogenase; Provisional; Region: PRK08194 192222007732 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 192222007733 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 2.3e-191 192222007734 PS00470 Isocitrate and isopropylmalate dehydrogenases signature 192222007735 2-isopropylmalate synthase; Validated; Region: PRK00915 192222007736 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 192222007737 active site 192222007738 catalytic residues [active] 192222007739 metal binding site [ion binding]; metal-binding site 192222007740 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 192222007741 HMMPfam hit to PF00682, HMGL-like, score 3.1e-133 192222007742 PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2 192222007743 PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1 192222007744 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 192222007745 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 192222007746 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 1.1e-55 192222007747 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 192222007748 1 probable transmembrane helix predicted for Cj1725 by TMHMM2.0 at aa 5-24 192222007749 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007750 homoserine O-succinyltransferase; Region: metA; TIGR01001 192222007751 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 192222007752 proposed active site lysine [active] 192222007753 conserved cys residue [active] 192222007754 HMMPfam hit to PF04204, Homoserine O-succinyltransferase, score 6.7e-185 192222007755 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 192222007756 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 192222007757 homodimer interface [polypeptide binding]; other site 192222007758 substrate-cofactor binding pocket; other site 192222007759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 192222007760 catalytic residue [active] 192222007761 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 1.3e-159 192222007762 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007763 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 192222007764 1 probable transmembrane helix predicted for Cj1728c by TMHMM2.0 at aa 20-42 192222007765 flagellar hook protein FlgE; Validated; Region: flgE; PRK08425 192222007766 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 192222007767 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 192222007768 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 192222007769 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 2e-20 192222007770 PS00017 ATP/GTP-binding site motif A (P-loop) 192222007771 HMMPfam hit to PF07559, Flagellar basal body protein FlaE, score 5.2e-32 192222007772 HMMPfam hit to PF07196, Flagellin hook IN motif,score 9.5e-08 192222007773 HMMPfam hit to PF00460, Flagella basal body rod protein, score 8.2e-12 192222007774 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 192222007775 active site 192222007776 putative DNA-binding cleft [nucleotide binding]; other site 192222007777 dimer interface [polypeptide binding]; other site 192222007778 HMMPfam hit to PF02075, Crossover junction endodeoxyribonuclease Ruv, score 7.9e-66